Dazzling Mirage was a Nigerian film that tells a story about what inherited blood disorder?
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Dazzling Mirage Dazzling Mirage is a 2014 Nigerian drama film, produced and directed by Tunde Kelani; it stars Kemi "Lala" Akindoju, Kunle Afolayan, Bimbo Manuel, Yomi Fash Lanso, Taiwo Ajai-Lycett and Seun Akindele. It also features special appearances from Adewale Ayuba, Sean Tizzle, Tunde Babalola and Steve Sodiya. The film is an adaptation of a novel of the same name by Olayinka Abimbola Egbokhare, adapted to screen by Ade Solanke. It tells the story of a young sickle-cell patient and the various social and emotional challenges she is faced with.
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Sickle-cell disease Sickle-cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle-cell anaemia (SCA). It results in an abnormality in the oxygen-carrying protein haemoglobin (hemoglobin S) found in red blood cells. This leads to a rigid, sickle-like shape under certain circumstances. Problems in sickle cell disease typically begin around 5 to 6 months of age. A number of health problems may develop, such as attacks of pain ("sickle-cell crisis"), anemia, swelling in the hands and feet, bacterial infections, and stroke. Long term pain may develop as people get older. The average life expectancy in the developed world is 40 to 60 years.
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Sideroblastic anemia Sideroblastic anemia or sideroachrestic anemia is a form of anemia in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). In sideroblastic anemia, the body has iron available but cannot incorporate it into hemoglobin, which red blood cells need in order to transport oxygen efficiently. The disorder may be caused either by a genetic disorder or indirectly as part of myelodysplastic syndrome, which can evolve into hematological malignancies (especially acute myelogenous leukemia).
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Hereditary benign intraepithelial dyskeratosis Hereditary benign intraepithelial dyskeratosis is a rare autosomal dominant disease of the conjunctiva and the oral mucosa caused by a duplication of chromosome 4q35. In the mouth it appears similar to white sponge nevus, with painless, diffuse, folded and spongy white plaques. In the eye it appears as gelatinous plaques on bulbar perilimbal conjunctiva.
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Blood (2012 film) Blood is a 2012 thriller that follows two brothers who are policemen and charts the moral collapse of a police family. The two brothers, played by Paul Bettany (Joe Fairburn) and Stephen Graham (Christie Fairburn) must investigate a despicable crime in a small town, in the shadow of their former police chief father. It was directed by Nick Murphy and written by Bill Gallagher.
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Abetalipoproteinemia Abetalipoproteinemia, or Bassen-Kornzweig syndrome, is a rare autosomal recessive disorder that interferes with the normal absorption of fat and fat-soluble vitamins from food. It is caused by a mutation in microsomal triglyceride transfer protein resulting in deficiencies in the apolipoproteins B-48 and B-100, which are used in the synthesis and exportation of chylomicrons and VLDL respectively. It is not to be confused with familial dysbetalipoproteinemia.
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Hemoglobin Lepore syndrome Hemoglobin Lepore syndrome or Hb Lepore syndrome (Hb Lepore) is typically an asymptomatic hemoglobinopathy, which is caused by an autosomal recessive genetic mutation. The Hb Lepore variant, consisting of two normal alpha globin chains (HBA) and two deltabeta globin fusion chains which occurs due to a "crossover" between the delta (HBD) and beta globin (HBB) gene loci during meiosis and was first identified in an Italian family in 1958. There are three varieties of Hb Lepore, Washington (Hb Lepore Washington, AKA Hb Lepore Boston or Hb Lepore Washington-Boston), Baltimore (Hb Lepore Baltimore) and Hollandia (Hb Hollandia). All three varieties show similar electrophoretic and chromatographic properties and hematological findings bear close resemblance to those of the beta-thalassemia trait; a blood disorder that reduces the production of the iron-containing protein hemoglobin which carries oxygen to cells and which may cause anemia.
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Haemorrhagic disease of the newborn Haemorrhagic disease of the newborn, also known as vitamin K deficiency bleeding (VKDB), is a coagulation disturbance in newborn infants due to vitamin K deficiency. As a consequence of vitamin K deficiency there is an impaired production of coagulation factors II, VII, IX, X, protein C and protein S by the liver, resulting in excessive bleeding (hemorrhage).
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Munchausen syndrome Munchausen syndrome is a factitious disorder wherein those affected feign disease, illness, or psychological trauma to draw attention, sympathy, or reassurance to themselves. Munchausen syndrome fits within the subclass of factitious disorder with predominantly physical signs and symptoms, but patients also have a history of recurrent hospitalization, travelling, and dramatic, extremely improbable tales of their past experiences. The condition derives its name from Baron Munchausen.
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Hypophosphatasia Hypophosphatasia (also called deficiency of alkaline phosphatase or phosphoethanolaminuria) is a rare, and sometimes fatal, metabolic bone disease. Clinical symptoms are heterogeneous, ranging from the rapidly fatal, perinatal variant, with profound skeletal hypomineralization and respiratory compromise, to a milder, progressive osteomalacia later in life. Tissue non-specific alkaline phosphatase (TNSALP) deficiency in osteoblasts and chondrocytes impairs bone mineralization, leading to rickets or osteomalacia. The pathognomonic finding is subnormal serum activity of the TNSALP enzyme, which is caused by one of 200 genetic mutations identified to date, in the gene encoding TNSALP. Genetic inheritance is autosomal recessive for the perinatal and infantile forms but either autosomal recessive or autosomal dominant in the milder forms. The prevalence of hypophosphatasia is not known; one study estimated the live birth incidence of severe forms to be 1:100,000.
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Benign hereditary chorea Benign hereditary chorea (BHC), also known as benign familial chorea, is a rare autosomal dominant neurogenetic syndrome. It typically presents in childhood with isolated chorea. Unlike other neurogenetic causes of chorea such as Huntington's disease, BHC is not progressive, and not associated with cognitive decline or psychiatric problems in the vast majority of cases.
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Knobloch syndrome Knobloch syndrome is a rare genetic disorder presenting severe eyesight problems and often a defect in the skull. It was named after W.H. Knobloch, who first described the syndrome in 1971. A usual occurrence is a degeneration of the vitreous humour and the retina, two components of the eye. This breakdown often results in the separation of the retina (the light-sensitive tissue at the back of the eye) from the eye, called retinal detachment, which can be recurrent. Extreme myopia (near-sightedness) is a common feature. The limited evidence available from electroretinography suggests a cone-rod pattern of dysfunction is also a feature.
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Muna Obiekwe Muna Obiekwe was a Nigerian actor. He was one of the most popular actors in Nigeria. On January 18, 2015, Obiekwe died from kidney disease. He was also the first cousin to Nigerian actor Yul Edochie.
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Samuel Manuwa Sir Samuel Layinka Ayodeji Manuwa, CMG, OBE (1903–1976) was a pioneering Nigerian surgeon, Inspector General of Medical Services and former Chief Medical Adviser to the Federal Government of Nigeria. He was the first Nigerian to pass the FRCS and he obtained the postgraduate Doctor of Medicine degree from the University of Edinburgh in 1934. In 1966, he was elected president of the World Federation for Mental Health. During his lifetime he served as a Nigerian aristocrat, holding the chieftaincy titles of the Obadugba of Ondoland, the Olowa Luwagboye of Ijebuland and the Iyasere of Itebu - Manuwa, all of the south-western region of the country.
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Dubin–Johnson syndrome Dubin–Johnson syndrome (DJS) is a rare, autosomal recessive, benign disorder that causes an isolated increase of conjugated bilirubin in the serum. Classically, the condition causes a black liver due to the deposition of a pigment similar to melanin. This condition is associated with a defect in the ability of hepatocytes to secrete conjugated bilirubin into the bile, and is similar to Rotor syndrome. It is usually asymptomatic, but may be diagnosed in early infancy based on laboratory tests. No treatment is usually needed.
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Gunther disease Gunther disease, also known as congenital erythropoietic porphyria (CEP), uroporphyrinogen III synthase deficiency and UROS deficiency, is a congenital form of erythropoietic porphyria. The word porphyria originated from the Greek word porphura. Porphura actually means "purple pigment", which, in suggestion, the color that the body fluid changes when a person has Gunther's disease. It is a rare, autosomal recessive metabolic disorder affecting heme, caused by deficiency of the enzyme uroporphyrinogen cosynthetase. It is extremely rare, with a prevalence estimated at 1 in 1,000,000 or less. There have been times that prior to birth of a fetus, Gunther's disease has been shown to lead to anemia. In milder cases patients have not presented any symptoms until they have reached adulthood. In Gunther's disease, porphyrins are accumulated in the teeth and bones and an increased amount are seen in the plasma, bone marrow, feces, red blood cells, and urine.
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Ade Solanke Adeola "Ade" Solanke is an award-winning British-Nigerian playwright and screenwriter. She is best known for her debut stage play, "Pandora's Box", which was produced at the Arcola Theatre in 2012, and was nominated as Best New Play in the Off West End Theatre Awards. Her other writing credits include the award-winning BBC Radio drama series "Westway" and the Nigerian feature film "Dazzling Mirage" (2014). She is the founder and creative director of the company Spora Stories, whose aim is to "create original drama for stage and screen, telling the dynamic stories of the African diaspora." Solanke has previously worked as an arts journalist and in radio and television, and in 1988 set up Tama Communications, offering a writing and publicity service, whose clients included the BBC, the Arts Council and the Midland Bank.
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Leber's hereditary optic neuropathy Leber's hereditary optic neuropathy (LHON) or Leber optic atrophy is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; this affects predominantly young adult males. LHON is only transmitted through the mother, as it is primarily due to mutations in the mitochondrial (not nuclear) genome, and only the egg contributes mitochondria to the embryo. LHON is usually due to one of three pathogenic mitochondrial DNA (mtDNA) point mutations. These mutations are at nucleotide positions 11778 G to A, 3460 G to A and 14484 T to C, respectively in the ND4, ND1 and ND6 subunit genes of complex I of the oxidative phosphorylation chain in mitochondria. Men cannot pass on the disease to their offspring.
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Ogugu Ogugu is a community of Igala-speaking people in the Olamaboro Local Government Area of the Kogi State in north central Nigeria. Ogugu people have a culture that has been misunderstood by other Igalas. It is called Ibegwu, literally meaning ancestors. It is believed that ancestors watch over their progeny to stop them from doing mischief. For instance, an Ogugu man can not be a party to premeditated murder. He would be 'arrested' by Ibegwu. He would be struck by some mysterious ailment, the cure to which is a public confession and performance of the necessary rituals for cleansing. According to the ancestral rules, a married woman cannot have an affair with any other man. The same punishment cited above applies. Some have argued that if a man has the liberty to flirt, a woman should also have the same right. They are predominantly subsistence farmers.
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Dentinogenesis imperfecta Dentinogenesis imperfecta (DI) is a genetic disorder of tooth development. This condition is a type of dentin dysplasia that causes teeth to be discolored (most often a blue-gray or yellow-brown color) and translucent giving teeth an opalescent sheen. Teeth are also weaker than normal, making them prone to rapid wear, breakage, and loss. These problems can affect both primary (deciduous) teeth and permanent teeth. This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. Dentinogenesis imperfecta affects an estimated 1 in 6,000 to 8,000 people.
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Li–Fraumeni syndrome Li–Fraumeni syndrome is a rare, autosomal dominant, hereditary disorder {except for the greater than 300,000 Brazilian carriers of the R337H variant } that pre-disposes carriers to cancer development. It was named after two American physicians, Frederick Pei Li and Joseph F. Fraumeni, Jr., who first recognized the syndrome after reviewing the medical records and death certificates of 648 childhood rhabdomyosarcoma patients. This syndrome is also known as the sarcoma, breast, leukaemia and adrenal gland (SBLA) syndrome.
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Donnai–Barrow syndrome Donnai–Barrow syndrome is a genetic disorder first described by Dian Donnai and Margaret Barrow in 1993. It is associated with "LRP2". It is an inherited (genetic) disorder that affects many parts of the body.