Derivatives of Phthalane, a bicyclic aromatic organic compound, are found in the drug Citalopram, which is what type of drug?
75c3ad5c3b86af0f82a5225883d015d9
Phthalane Phthalane is a bicyclic aromatic organic compound. It is also known as isocoumaran, or 1,3-dihydro-2-benzofuran. Derivatives are found in the drug Citalopram, and drug candidate Lu 10-171. It can be oxidised to phthalic acid.
d4fd227385ae8e997c8f6fafcb9ab3b8
Citalopram Citalopram (brand names: Celexa, Cipramil and others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class. It has U.S. Food and Drug Administration approval to treat major depression, which it received in 1998, and is prescribed off-label for other conditions. In Australia, the UK, Germany, Portugal, Poland, and most European countries, it is licensed for depressive episodes and panic disorder with or without agoraphobia. In Spain and Denmark it is also used for obsessive–compulsive disorder.
d461a247670d2a1fd05ce45e927bed80
Substituted benzofuran The substituted benzofurans are a class of chemical compounds based on the heterocyclyc and polycyclic compound benzofuran. Some compounds in this class are psychoactive drugs including stimulants, psychedelics and empathogens. Some psychoactive derivatives from this family have been sold under the name "Benzofury".
d7171b2d718ea7456daa1aa92a644e2e
Cyclopropenone Cyclopropenone is an organic compound with molecular formula CHO consisting of a cyclopropene carbon framework with a ketone functional group. It is a colorless, volatile liquid that boils near room temperature. The chemical properties of the compound are dominated by the strong polarization of the carbonyl group, which gives a partial positive charge with aromatic stabilization on the ring and a partial negative charge on oxygen. It is an aromatic compound.
ec611ccacf62356fc570106e231dfd64
Cinitapride Cinitapride (trade names Cintapro, Pemix) is a gastroprokinetic agent and antiulcer agent of the benzamide class which is marketed in India, Mexico, Pakistan and Spain. It acts as an agonist of the 5-HT and 5-HT receptors and as an antagonist of the 5-HT receptors.
6a41132e5dc149e653d730a9777c69c9
Doxofylline Doxofylline (also known as doxophylline) is a xanthine derivative drug used in the treatment of asthma.
66394ee03ebf88ca1e6969309ff76d66
Pyrethrin The pyrethrins are a class of organic compounds normally derived from "Chrysanthemum cinerariifolium" that have potent insecticidal activity by targeting the nervous systems of insects. Pyrethrin is synthetically made by industrial methods, but it also naturally occurs in chrysanthemum flowers, thus is often considered an organic insecticide, or at least when it is not combined with piperonyl butoxide or other synthetic adjuvants. Their insecticidal and insect-repellent properties have been known and used for thousands of years.
d2a9e8b7653ce6bda8db25371ac5b9c6
Methamphetamine Methamphetamine (contracted from "N"-methylamphetamine ) is a strong central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. "Methamphetamine" properly refers to a specific chemical, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms. It is rarely prescribed due to concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy. Dextromethamphetamine is a much stronger CNS stimulant than levomethamphetamine.
2c566651729957b5f06bb425df96e842
Piberaline Piberaline (EGYT-475; Trelibet) is a psychoactive drug and member of the piperazine chemical class which was developed in the 1980s. It has stimulant and antidepressant effects which are thought to be due largely to its active metabolite benzylpiperazine. It was researched to a limited extent in Hungary and Spain, but was not widely accepted and does not seem to be in current use, although a closely related drug befuraline with similar effects has been slightly more successful.
d4d9a63adedcee9e38b3e2933cc472bf
Phenothiazine Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(CH)NH and is related to the thiazine-class of heterocyclic compounds. Although the parent compound has no uses, derivatives of phenothiazine are highly bioactive and have widespread use and rich history. The derivative chlorpromazine revolutionized the field of psychiatry and allergy treatment. An earlier derivative, methylene blue, was one of the first antimalarial drugs, and as of 2015 derivatives are under investigation as possible anti-infective drugs. Phenothiazine is a prototypical pharmaceutical lead structure in medicinal chemistry.
0dc4cb2df082f3a182a8731180ecf11a
Phthalonitrile Phthalonitrile is an organic compound with the formula CH(CN), which is an off-white crystal solid at room temperature. It is a derivative of benzene, containing two adjacent nitrile groups. The compound has low solubility in water but is soluble in common organic solvents. The compound is used as a precursor to phthalocyanine and other pigments, fluorescent brighteners, and photographic sensitizers.
d93172dac9feb6244f5d99207c947454
Party pills Party pills, also known as "herbal highs", "pep pills" "dance pills" and "natural power", is a colloquialism for a type of recreational drug whose main ingredient was originally benzylpiperazine (BZP), but has expanded to a wide range of compounds with a variety of effects. BZP is banned in a few countries, including the USA, Republic of Ireland, Australia and New Zealand, but is available on a more or less restricted basis in many jurisdictions. A range of other piperazine derivatives have also been sold as ingredients in party pills, and many of these branded "proprietary blends" have subsequently been sold in countries around the world.
4946ae764288570baff2b179d77258ce
Pyrrolizidine Pyrrolizidine is a heterocyclic organic compound that forms the central chemical structure of a variety of alkaloids known collectively as pyrrolizidine alkaloids.
1b4992e684658eefdf4ce859eff72981
Arfendazam Arfendazam (INN) is a drug which is a benzodiazepine derivative. Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.
4d093757bd2780f3cf2e1443038d8629
Fluacizine Fluacizine, sold under the brand name Phtorazisin, is a tricyclic antidepressant (TCA) of the phenothiazine group which is or was marketed in Russia. Unlike other phenothiazines, fluacizine is not an antipsychotic, and can actually reverse catalepsy and extrapyramidal symptoms induced by antidopaminergic agents like antipsychotics, reserpine, and tetrabenazine as well as potentiate amphetamine-induced stereotypy. It is known to act as a norepinephrine reuptake inhibitor, antihistamine, and anticholinergic. The drug was developed in the 1960s and was marketed in the 1970s. It is the trifluoromethyl analogue of chloracizine.
80a26f655b1bfb84df3a17c1234f25e6
2,3-Dichlorophenylpiperazine 2,3-Dichlorophenylpiperazine (2,3-DCPP or DCPP) is a chemical compound. It is both a precursor in the synthesis of aripiprazole and one of its metabolites. It is unclear whether 2,3-DCPP is pharmacologically active similar to its close analogue 3-chlorophenylpiperazine ("m"CPP).
34041a68dd975e0c5a0066e7d59b2fd8
Tropoxane Tropoxane is an aryloxytropane derivative drug developed by Organix Inc., which acts as a stimulant and potent dopamine and serotonin reuptake inhibitor. It is an analogue of dichloropane where the amine nitrogen has been replaced by an oxygen ether link (at the bridgehead position), demonstrating that the amine nitrogen is not required for DAT binding and reuptake inhibition.
9bc11639daffec4920dee2fa112dfd47
Phthalazine Phthalazine, also called benzo-orthodiazine or benzopyridazine, is a heterocyclic organic compound with the molecular formula CHN. It is isomeric with other naphthyridines including quinoxaline, cinnoline and quinazoline.
2a365b35755fa82e66d1f5c2c3ff8464
Eltoprazine Eltoprazine (DU-28,853) is a drug of the phenylpiperazine class which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT and 5-HT receptors and as an antagonist at the 5-HT receptor. It is closely related to fluprazine and batoprazine, which are similarly acting drugs.
43d4a3914ee92603833b4b38df5d12f7
Sulpiride Sulpiride (brand names Dogmatil , Dolmatil , Eglonyl , Espiride , Modal , Prometar , Sulpor and others) is an atypical antipsychotic drug (although some texts have referred to it as a typical antipsychotic) of the benzamide class used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. Sulpiride is commonly used in Asia, Central America, Europe, South Africa and South America. Levosulpiride is its purified levo-isomer and is sold in India for similar purpose. So far it has not been approved in the United States, Canada and Australia. The drug is chemically and clinically similar to amisulpride.
83a5ef61d4c7976a9fd37b17e3c6fe76
Tofenacin Tofenacin (INN; Elamol, Tofacine, Tofalin), or tofenacin hydrochloride (USAN), also sometimes called "mono"-"N"-desmethylorphenadrine, is an antidepressant drug with a tricyclic-like structure which was developed and marketed in the United Kingdom and Italy in 1971 and 1981, respectively, by Brocades-Stheeman & Pharmacia (now part of Astellas Pharma). It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. In addition to its use as a pharmaceutical medication, tofenacin is the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.
ad755ac96ec0945bd6ade22518fe7332
4'-Methyl-α-pyrrolidinohexiophenone 4'-Methyl-α-pyrrolidinohexiophenone or MPHP is a stimulant compound which has been reported as a novel designer drug. It is closely related to pyrovalerone, being simply its chain-lengthened homologue. In the pyrrolidinophenone series, stimulant activity is maintained so long as the positions of the aryl, ketone and pyrrolidinyl groups are held constant, while the alkyl backbone can be varied anywhere between three and as many as seven carbons, with highest potency usually seen with the pentyl or isohexyl backbone, and a variety of substituents are tolerated on the aromatic ring.