What is the study of the properties of this mechanism which is used by Smart insulin to control the glucose level?
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Smart insulin Smart insulin (also known as glucose responsive insulin, adaptive insulin, smart insulin patch, or MK-2640-001 (Merck)) is a promising and experimental type of insulin that automatically manages blood sugars and keeps them in the normal range in diabetics. Its purpose is to treat and prevent hyperglycemia. Smart insulin is supposed to adapt by releasing either less or more insulin relative to the level of glucose in the bloodstream to keep it stable.
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Circulatory system The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis. The study of the blood flow is called hemodynamics. The study of the properties of the blood flow is called hemorheology.
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Silicon controlled rectifier A silicon controlled rectifier or semiconductor-controlled rectifier is a four-layer solid-state current-controlling device. The principle of four layer p-n-p-n switching was developed by Moll, Tanenbaum, Goldey and Holonyak of Bell Laboratories in 1956. The practical demonstration of silicon controlled switching and detailed theoretical behavior of a device in agreement with the experimental results was presented by Dr Ian M. Mackintosh of Bell Laboratories in January 1958.
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Quantitative insulin sensitivity check index The quantitative insulin sensitivity check index (QUICKI) is derived using the inverse of the sum of the logarithms of the fasting insulin and fasting glucose:
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Glucagon-like peptide-1 receptor agonist Glucagon-like peptide-1 receptor agonists also known as GLP-1 receptor agonists or incretin mimetics are agonists of the GLP-1 receptor. This class of drugs is used for the treatment of type 2 diabetes. One of their advantages over older insulin secretagogues, such as sulfonylureas or meglitinides, is that they have a lower risk of causing hypoglycemia.
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Randle cycle The Randle cycle, also known as the glucose fatty-acid cycle, is a metabolic process involving the competition of glucose and fatty acids for substrates. It is theorized to play a role in explaining type 2 diabetes and insulin resistance.
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Electrodialysis Electrodialysis (ED) is used to transport salt ions from one solution through ion-exchange membranes to another solution under the influence of an applied electric potential difference. This is done in a configuration called an electrodialysis cell. The cell consists of a feed (dilute) compartment and a concentrate (brine) compartment formed by an anion exchange membrane and a cation exchange membrane placed between two electrodes. In almost all practical electrodialysis processes, multiple electrodialysis cells are arranged into a configuration called an electrodialysis with alternating anion and cation exchange membranes forming the multiple electrodialysis cells. Electrodialysis processes are different from distillation techniques and other membrane based processes (such as reverse osmosis (RO)) in that dissolved species are moved away from the feed stream rather than the reverse. Because the quantity of dissolved species in the feed stream is far less than that of the fluid, electrodialysis offers the practical advantage of much higher feed recovery in many applications.
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Thermoelectric cooling Thermoelectric cooling uses the Peltier effect to create a heat flux between the junction of two different types of materials. A Peltier cooler, heater, or thermoelectric heat pump is a solid-state active heat pump which transfers heat from one side of the device to the other, with consumption of electrical energy, depending on the direction of the current. Such an instrument is also called a Peltier device, Peltier heat pump, solid state refrigerator, or thermoelectric cooler (TEC). It can be used either for heating or for cooling, although in practice the main application is cooling. It can also be used as a temperature controller that either heats or cools.
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Counterimmunoelectrophoresis Counterimmunoelectrophoresis is a laboratory technique used to evaluate the binding of an antibody to its antigen, it is similar to immunodiffusion, but with the addition of an applied electrical field across the diffusion medium, usually an agar or polyacrylamide gel. The effect is rapid migration of the antibody and antigen out of their respective wells towards one another to form a line of precipitation, or a precipitin line, indicating binding.
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Lipidomics Lipidomics is the large-scale study of pathways and networks of cellular lipids in biological systems The word "lipidome" is used to describe the complete lipid profile within a cell, tissue, organism, or ecosystem and is a subset of the "metabolome" which also includes the three other major classes of biological molecules: proteins/amino-acids, sugars and nucleic acids. Lipidomics is a relatively recent research field that has been driven by rapid advances in technologies such as mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, fluorescence spectroscopy, dual polarisation interferometry and computational methods, coupled with the recognition of the role of lipids in many metabolic diseases such as obesity, atherosclerosis, stroke, hypertension and diabetes. This rapidly expanding field complements the huge progress made in genomics and proteomics, all of which constitute the family of systems biology.
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Hydraulic circuit A hydraulic circuit is a system comprising an interconnected set of discrete components that transport liquid. The purpose of this system may be to control where fluid flows (as in a network of tubes of coolant in a thermodynamic system) or to control fluid pressure (as in hydraulic amplifiers). For example, hydraulic machinery uses hydraulic circuits (in which hydraulic fluid is pushed, under pressure, through hydraulic pumps, pipes, tubes, hoses, hydraulic motors, hydraulic cylinders, and so on) to move heavy loads. The approach of describing a fluid system in terms of discrete components is inspired by the success of electrical circuit theory. Just as electric circuit theory works when elements are discrete and linear, hydraulic circuit theory works best when the elements (passive component such as pipes or transmission lines or active components such as power packs or pumps) are discrete and linear. This usually means that hydraulic circuit analysis works best for long, thin tubes with discrete pumps, as found in chemical process flow systems or microscale devices.
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Electrical cardiometry Electrical cardiometry is a method based on the model of "Electrical Velocimetry", and non-invasively measures stroke volume (SV), cardiac output (CO), and other hemodynamic parameters through the use of 4 surface ECG electrodes. Electrical cardiometry is a method trademarked by Cardiotronic, Inc., and is U.S. FDA approved for use on adults, children, and neonates.
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Renal physiology Renal physiology (Latin "rēnēs", "kidneys") is the study of the physiology of the kidney. This encompasses all functions of the kidney, including maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small molecules; regulation of blood pressure; production of various hormones, such as erythropoietin; and activation of vitamin D.
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Bang–bang control In control theory, a bang–bang controller (2 step or on–off controller), also known as a hysteresis controller, is a feedback controller that switches abruptly between two states. These controllers may be realized in terms of any element that provides hysteresis. They are often used to control a plant that accepts a binary input, for example a furnace that is either completely on or completely off. Most common residential thermostats are bang–bang controllers. The Heaviside step function in its discrete form is an example of a bang–bang control signal. Due to the discontinuous control signal, systems that include bang–bang controllers are variable structure systems, and bang–bang controllers are thus variable structure controllers.
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Smart gun A smart gun, or "personalized gun", is a firearm that includes a safety feature or features that allow it to fire only when activated by an authorized user. These safety features can prevent misuse, accidental shootings, gun thefts, and use of the weapon against the owner. Smart guns distinguish between authorized users and unauthorized users in several different ways, including the use of RFID chips or other proximity tokens, fingerprint recognition, magnetic rings, or mechanical locks. Related to smart guns are other smart firearms safety devices such as biometric or RFID activated accessories and safes.
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Gastric inhibitory polypeptide Gastric inhibitory polypeptide (GIP), also known as the glucose-dependent insulinotropic peptide, is an inhibiting hormone of the secretin family of hormones.
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Insulin index The Insulin Index of a food represents how much it elevates the concentration of insulin in the blood during the two-hour period after the food is ingested. The index is similar to the Glycemic Index (GI) and Glycemic Load (GL), but rather than relying on blood glucose levels, the Insulin Index is based upon blood insulin levels. The Insulin Index represents a comparison of food portions with equal overall caloric content (250 kcal or 1000 kJ), while GI represents a comparison of portions with equal digestible carbohydrate content (typically 50 g) and the GL represents portions of a typical serving size for various foods. The Insulin Index can be more useful than either the Glycemic Index or the Glycemic Load because certain foods (e.g., lean meats and proteins) cause an insulin response despite there being no carbohydrates present, and some foods cause a disproportionate insulin response relative to their carbohydrate load.
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Hyperpolarizability The hyperpolarizability, a nonlinear-optical property of a molecule, is the second-order electric susceptibility per unit volume. See nonlinear optics.
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Benfluorex Benfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine patented and manufactured by a French pharmaceutical company Servier. Two clinical studies have shown it may improve glycemic control and decrease insulin resistance in people with poorly controlled type 2 diabetes. However, Servier is suspected of having marketed Mediator (benfluorex) at odds with the drug's medical properties.
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Insulin-like growth factor 2 Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on somatotropin. It is believed to be a major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults".
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Voltage clamp The voltage clamp is an experimental method used by electrophysiologists to measure the ion currents through the membranes of excitable cells, such as neurons, while holding the membrane voltage at a set level. A basic voltage clamp will iteratively measure the membrane potential, and then change the membrane potential (voltage) to a desired value by adding the necessary current. This "clamps" the cell membrane at a desired constant voltage, allowing the voltage clamp to record what currents are delivered. Because the currents applied to the cell must be equal to (and opposite in charge to) the current going across the cell membrane at the set voltage, the recorded currents indicate how the cell reacts to changes in membrane potential. Cell membranes of excitable cells contain many different kinds of ion channels, some of which are voltage-gated. The voltage clamp allows the membrane voltage to be manipulated independently of the ionic currents, allowing the current-voltage relationships of membrane channels to be studied.
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Glucose 1-phosphate Glucose 1-phosphate (also called cori ester) is a glucose molecule with a phosphate group on the 1'-carbon. It can exist in either the α- or β-anomeric form.