What Swiss multinational healthcare company, introduced the steroidal progestin, Trengestone, in 1974?
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Trengestone Trengestone (INN) (brand names Reteroid, Retroid, Retrone; former developmental code name Ro 4-8347), also known as 6-chloro-6,7-didehydroretroprogesterone or 6-chloro-9β-10α-pregna-1,4,6-triene-3,20-dione, is a steroidal progestin of the retroprogesterone group related to dydrogesterone that was formerly used to treat menstrual disorders. It was synthesized in 1964 and was introduced for medical use by Roche in 1974.
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Hoffmann-La Roche F. Hoffmann-La Roche AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has bearer shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel.
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Actelion Actelion is a pharmaceuticals and bio-technology company established in December 1997, headquartered in Allschwil near Basel in Switzerland. Its CEO and co-founder is cardiologist Jean-Paul Clozel.
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Mathys Medical Mathys Ltd Bettlach (formerly Mathys Medical), is a Swiss family business with headquarters in Bettlach, Switzerland. The company develops, produces and distributes implants for artificial joint replacement in the areas of hip, knee and shoulder as well as biomaterials for surgical treatment of bone defects (bone grafting) With an innovative implant for ACL healing, the family company also gained ground in the area of sport orthopaedics at the beginning of 2013.
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Getinge Group Getinge AB is a global medical technology company, founded in Sweden in 1904. The firm provides equipment and systems within healthcare and life sciences. The company was formerly organised in three business areas: Infection Control (trading as Getinge), Extended Care (ArjoHuntleigh) and Medical Systems (Maquet, the world's largest maker of surgical tables), but announced it would become a single brand company, operating under the brand Getinge, on March 20 2017. The company's president and CEO is Mattias Perjos. Carl Bennet is the company's chairman. Getinge's shares have been listed on the OMX Nordic List in Stockholm since 1993 and have formed part of the OMXS30 index since July 2009.
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Clostebol acetate Clostebol acetate (BAN) (brand names Macrobin, Steranabol, Alfa-Trofodermin, Megagrisevit), also known as 4-chlorotestosterone 17β-acetate (4-CLTA) or as 4-chloroandrost-4-en-17β-ol-3-one 17β-acetate, is a synthetic, injected anabolic-androgenic steroid (AAS) and a derivative of testosterone that is marketed in Germany and Italy. It is an androgen ester – specifically, the C17β acetate ester of clostebol (4-chlorotestosterone) – and acts as a prodrug of clostebol in the body. Clostebol acetate is administered via intramuscular injection.
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Nandrolone decanoate Nandrolone decanoate (USAN, BAN) (brand names Deca-Durabolin, Deca-Durabol, Decaneurabol, Metadec, Retabolil), or nandrolone decylate, also known as 19-nortestosterone 17β-decanoate or 17β-[(1-oxodecyl)oxy]estr-4-en-3-one, is a synthetic androgen and anabolic steroid and a nandrolone ester. It was introduced in 1962. Along with nandrolone phenylpropionate (NPP), nandrolone decanoate is one of the most widely used nandrolone esters, and is marketed in many countries throughout the world, including in the United States, Canada, and United Kingdom. Both nandrolone decanoate and NPP are prodrugs of nandrolone.
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Mecigestone Mecigestone, also known as pentarane B, as well as 6α-methyl-16α,17α-cyclohexanoprogesterone, 6α-methylcyclohexano[1',2';16,17]pregn-4-ene-3,20-dione, or 17α-acetyl-6α-methyl-16β,24-cyclo-21-norchol-4-en-3-one, is a steroidal progestin that was developed by the Zelinskii Institute of Organic Chemistry of the Russian Academy of Sciences and has been proposed for clinical use as a progestogen but has not been marketed. It is the 6α-methylated analogue of pentarane A, which is also known as D'6-pentarane or pregna-D'6-pentarane.
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Cilag Cilag AG is a Swiss pharmaceutical company. Cilag is a subsidiary of American pharmaceutical giant Johnson & Johnson. The company's global marketing activities are operated by Janssen-Cilag, a merger with another Johnson & Johnson subsidiary, Janssen Pharmaceutica.
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Medrysone Medrysone (INN, USAN) (brand names HMS, Medrocort, others; former developmental code name NSC-63278), also known as hydroxymethylprogesterone, methylhydroxyprogesterone, or hydroxymesterone, as well as 6α-methyl-11β-hydroxyprogesterone or 6α-methyl-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic glucocorticoid that is or has been used in the treatment of inflammatory eye diseases. It has been discontinued in the United States. Although it is very similar in structure to progesterone, neither progestogenic nor androgenic activity has been demonstrated for or attributed to medrysone.
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Estradiol/progesterone Estradiol/progesterone (developmental code name TX-001HR, formerly TX-12-001HR) is an oral combination of estradiol, an estrogen, and progesterone, a progestogen, that is under development by TherapeuticsMD for the treatment of menopausal symptoms and endometrial hyperplasia. It is currently in phase III clinical trials for these indications. The drug is the first combination of estradiol and progesterone that has been developed for clinical use.
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Pentarane A Pentarane A, also known as D'6-pentarane or pregna-D'6-pentarane, as well as 16α,17α-cyclohexanoprogesterone, 16α,17α-tetramethylenepregn-4-ene-3,20-dione, or 17α-acetyl-16β,24-cyclo-21-norchol-4-en-3-one, is a steroidal progestin that was developed by the Zelinskii Institute of Organic Chemistry of the Russian Academy of Sciences and was never marketed. The 6α-methylated analogue of pentarane A is known as mecigestone or as "pentarane B".
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Swisse Swisse is an Australian vitamin and supplement company, that also manufacturers personal care products. The CEO is Radek Sali. In September 2015 86% of the company was bought by Hong Kong-listed Chinese company Biostime.
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Progesterone (medication) Progesterone is a medication and naturally occurring steroid hormone. It is a progestogen and neurosteroid and is used mainly in hormone replacement therapy (HRT) for menopause, hypogonadism, and transgender women. Progesterone can be taken by mouth, in through the vagina, and by injection into muscle or fat, among other routes. A progesterone vaginal ring form used for birth control also exists in some areas of the world.
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Desogestrel Desogestrel, sold under the brand names Azalia, Cerazette, Marvelon, Mircette, Mercilon, and Novynette among others, is a progestin that is used in hormonal contraceptives. Most combined oral contraceptive pills (COCPs, or simply OCs) on the market today contain both an estrogen (usually ethinylestradiol) plus a progestin (a synthetic progesterone-like agent) such as desogestrel. Desogestrel-containing birth control pills are sometimes referred to as "third generation" oral contraceptives. In contrast, birth control pills that are considered "second generation" (Tri-Levlen, for example) contain an estrogen and a progestin, but the progestin is different, such as levonorgestrel.
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Tiomesterone Tiomesterone (INN, JAN) (brand names Emdabol, Embadol, Emdabolin, Protabol; former developmental code name StA 307), or thiomesterone (BAN), also known as 1α,7α-bis(acetylthio)-17α-methylandrost-4-en-17β-ol-3-one, is a synthetic, orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of testosterone. It was described in 1963.
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Swiss Barefoot Company The Swiss Barefoot Company is a sock manufacturer based in Switzerland.
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Nestlé Nestlé S.A. is a Swiss transnational food and drink company headquartered in Vevey, Vaud, Switzerland. It has been the largest food company in the world, measured by revenues and other metrics, for 2014, 2015, and 2016. It ranked No. 72 on the Fortune Global 500 in 2014 and No. 33 on the 2016 edition of the Forbes Global 2000 list of largest public companies.
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Quingestanol Quingestanol (INN, BAN), also known as norethisterone 3-cyclopentyl enol ether, is a steroidal progestin of the 19-nortestosterone group which was never marketed. It is a prodrug of norethisterone. An acylated derivative, quingestanol acetate, is used as a pharmaceutical drug.
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Theraplix Theraplix is a European pharmaceutical company.
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Antiprogestogen Antiprogestogens, or antiprogestins, also known as progesterone antagonists or progesterone blockers, are a class of drugs which prevent progestogens like progesterone from mediating their biological effects in the body. They act by blocking the progesterone receptor (PR) and/or inhibiting or suppressing progestogen production. Antiprogestogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiandrogens.
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International Osteoporosis Foundation The International Osteoporosis Foundation (IOF), headquartered in Nyon, Switzerland, is a non-governmental organization founded in 1998. It was formed from the merger of the European Foundation for Osteoporosis, founded in 1987, and the International Federation of Societies on Skeletal Diseases. The foundation functions as a global alliance of individuals and organizations concerned with the prevention, diagnosis and treatment of osteoporosis and musculoskeletal bone disease. The goal of the Foundation is to increase the early detection of osteoporosis and related musculoskeletal diseases, as well as to improve the treatment of these conditions through international collaboration among national healthcare systems and governments. The Foundation is the largest global NGO dedicated to osteoporosis and musculoskeletal diseases.