what causes hi ast & alt levels
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What Could Be Causing Elevated Levels of AST and ALT Levels? Other possible causes of high ALT and AST levels include Wilson's disease, cirrhosis, inflammation of the gallbladder and pancreatitis, explains Mayo Clinic. Most often, elevated liver enzymes are only slightly elevated and do not indicate a problem with the liver. This condition is normally only temporary.
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- 1 Fatty liver disease can cause elevated ALT levels, as well, especially alcoholic fatty liver disease. 2  Hemochromatosis has also been known to cause high ALT levels. 3  This is a genetic condition caused by iron build-up in the liver. 4  Diminished blood flow to the liver will also elevate your ALT levels.
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- AST (SGOT) and ALT (SGPT) are sensitive indicators of liver damage or injury from different types of diseases. But it must be emphasized that higher-than-normal levels of these liver enzymes should not be automatically equated with liver disease. They may mean liver problems or they may not.
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The AST/ALT Story Levels of ALT may also be markedly elevated (sometimes over 100 times normal) as a result of exposure to drugs or other substances that are toxic to the liver as well as in conditions that cause decreased blood flow (ischemia) to the liver.
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- Elevations of ALT and AST are not exclusive to liver pathology. Hyperthyroidism has been found in several studies to increase serum levels of liver enzymes including ALT and AST. 8 Genetic influences on the level of ALT also are possible.
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The AST/ALT Story AST may also increase after heart attacks and with muscle injury, usually to a much greater degree than ALT. In most types of liver disease, the ALT level is higher than AST and the AST/ALT ratio will be low (less than 1).
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- High ALT levels in fatty liver and Elevated ALT levels. High ALT levels in fatty liver or elevated ALT levels in fatty liver (also called Alanine Transaminase and SGPT) in a fatty liver blood test can be a sign of a the severity of fatty liver disease from mild to serious.t’s worth mentioning that in a more severe liver diseases (like Cirrhosis), the ALT levels would be much higher than elevated ALT levels in when it’s a fatty liver. First thing you need to do is NOT to get in panic.
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AST Levels High AST levels can also be produced by some types of cancer, recent ingestion of high amounts of vitamin A, mononucleosis, and as a side effect of a long list of medications, including statins (anti-cholesterol medication), many antibiotics, chemotherapy, large doses of aspirin, barbiturates, and opioid drugs (narcotics).
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Aspartate Aminotransferase (AST/SGOT) A wide range of disease entities alters AST (SGOT), with origin from many organs. When an increased AST is from the liver, it is more likely to relate to disease of the hepatocyte. Other enzymes, including alkaline phosphatase and GT, are more sensitive indicators of biliary obstruction. Causes of low AST: uremia, vitamin B6 deficiency (this can be corrected), metronidazole, trifluoperazine.
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- An increased AST level is usually a sign of liver disease. Liver disease is even more likely when the levels of substances checked by other liver blood tests have also increased. An increased AST level may be due to any of the following:
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- AST levels less than 37 U/L in men and less than 31 U/L in women, as normal thresholds. Although ALT is present in several organs and in muscle, the highest levels are in the liver, which makes this enzyme a more specific indicator of liver injury. Both AST and ALT are released into the blood in greater amounts when hepatocytes are damaged.
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Elevated Liver Enzymes AST (SGOT) and ALT (SGPT) are sensitive indicators of liver damage from different types of disease. In rare cases, higher-than-normal levels of these liver enzymes may have causes other than liver problems. The interpretation of elevated AST and ALT levels depends upon the whole clinical picture.
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- The AST test is commonly used to check for liver diseases. It is usually measured together with alanine aminotransferase (ALT). The AST to ALT ratio can help your doctor diagnose liver disease. Symptoms of liver disease that may cause your doctor to order an AST test include: 1  fatigue. 2  weakness. 3  loss of appetite. 4  nausea or vomiting. 5  swelling in the abdomen. 6  yellow skin or eyes (jaundice). 7  dark urine.
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- Elevated al-kaline phosphatase and aminotransferases can indicate a mixed pattern of injury. High AST, ALT suggest liver cell damage Both aspartate aminotransferase (AST) and ALT are normally present in serum at low lev-els, usually less than 30 to 40 U/L. Although the actual values may differ from laboratory to laboratory, normal serum levels are usually less than 40 U/L for AST and less than 50 U/L for ALT.
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The AST/ALT Story Levels of AST may also be markedly elevated (often over 100 times normal) as a result of exposure to drugs or other substances that are toxic to the liver as well as in conditions that cause decreased blood flow (ischemia) to the liver.ith heart or muscle injury, AST is often much higher than ALT (often 3-5 times as high) and levels tend to stay higher than ALT for longer than with liver injury. AST is often performed together with the ALT test or as part of a liver panel.
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Prurigo Pigmentosa â The Ketosis Rash Nobody Warned Me About With heart or muscle injury, AST is often much higher than ALT (often 3-5 times as high) and levels tend to stay higher than ALT for longer than with liver injury. AST is often performed together with the ALT test or as part of a liver panel.ery high levels of AST (more than 10 times normal) are usually due to acute hepatitis, sometimes due to a viral infection. With acute hepatitis, AST levels usually stay high for about 1-2 months but can take as long as 3-6 months to return to normal.
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Elevated Liver Enzymes The liver releases several substances when it is injured. Two of these are enzymes called alanine transaminase (ALT) and aspartate transaminase (AST). There are many causes of mildly elevated ALT and AST levels. About three out of 10 people will have normal levels again if blood tests are repeated in two to four weeks.
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AST Levels If ALT is also found to be elevated, the presence of liver disease is more strongly indicated. In that case, elevated AST can help to identify the cause. If the elevation of AST is higher than that of ALT, this is a strong indicator that the damage to the liver is alcohol-related.
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AST/ALT ratio Most causes of liver cell injury are associated with an AST that is lower than the ALT. However, an AST to ALT ratio of 2:1 or greater is suggestive of alcoholic liver disease, particularly in the setting of an elevated gamma-glutamyl transferase.
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- in medicine the presence of elevated transaminases commonly the transaminases alanine transaminase alt and aspartate transaminase ast may be an indicator of liver damage other terms employed include transaminasemia and transaminitis although some sources consider the latter pathologically meaningless
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What Causes High Liver Enzyme Levels? So what causes high liver enzyme levels to show up in a liver-function blood test? Alanine transaminase, or ALT, and aspartate transaminase, or AST, are the two most common liver enzymes to be tested. It is relatively common for one or both of these liver enzymes to be high.
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- With heart or muscle injury, AST is often much higher than ALT (often 3-5 times as high) and levels tend to stay higher than ALT for longer than with liver injury. AST is often performed together with the ALT test or as part of a liver panel. For more about AST results in relation to other liver tests, see the Liver Panel article.
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Rapid Review Pathology High levels of AST may be caused by: 1  Liver damage from conditions such as hepatitis or cirrhosis. 2  A heart attack or heart failure. 3  Many medicines, such as statins, antibiotics, chemotherapy, aspirin, narcotics, and barbiturates. 4  High doses of vitamin A.
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Liver Problems - Liver Dysfunction (Hepatotoxicity) Brought On By Chemotherapy 1 Your liver enzymes may be elevated if: 2  You have an infection, blockage or damage to your liver. 3  There may be a blockage to the liver, gall bladder or the common bile duct, such as gallstones, tumor, or infection. 4  Certain drugs or medications may have damaged your liver. Your liver enzymes may be elevated, even if there is no damage to the liver. 2  In example, ALP is made by the bones and the liver. 3  Your blood ALP levels may be elevated due to damaged the bones, not a damaged liver. 4  ALT, AST levels may be elevated if there is damage to the heart.