somatostatin receptor
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- The somatostatin receptor family is a member of the G-protein-coupled receptor superfamily and consists of 5 subtypes each differentially distributed throughout the CNS and periphery. These receptors bind with high affinity to the endogenous polypeptides somatostatin-14, somatostatin-28 and cortistatin, as well as a vast array of synthetic ligands.
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Somatostatin Somatostatin (also known as growth hormone-inhibiting hormone (GHIH) or somatotropin release-inhibiting factor (SRIF)) is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G-protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones ...
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Cutaneous receptor The cutaneous receptors are the types of sensory receptor found in the dermis or epidermis. They are a part of the somatosensory system. Cutaneous receptors include e.g. cutaneous mechanoreceptors, nociceptors (pain) and thermoreceptors (temperature).ith the above-mentioned receptor types the skin can sense the modalities touch, pressure, vibration, temperature and pain. The modalities and their receptors are partly overlapping, and are innervated by different kinds of fiber types.
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HER2/neu The ErbB family is composed of four plasma membrane-bound receptor tyrosine kinases, the other members being epidermal growth factor receptor, erbB-3 (neuregulin-binding; lacks kinase domain), and erbB-4.ER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor.
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- Somatostatin. 1  the stomach (thus a paracrine effect) where it inhibits the release of gastrin and hydrochloric acid. 2  the duodenum where it inhibits the release of secretin and cholecystokinin. 3  the pancreas where it inhibits the release of glucagon. Many of them are also found in other tissues, especially the brain. 2  Many act in a paracrine manner as well as being carried in the blood as true hormones. 3  Their importance to health is uncertain as no known deficiency disorders have been found for any of them.
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Mechanism of Action: Hormones with Cell Surface Receptors Tyrosine Kinase Second Messenger Systems. The receptors for several protein hormones are themselves protein kinases which are switched on by binding of hormone. The kinase activity associated with such receptors results in phosphorylation of tyrosine residues on other proteins.
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MCL Tear The medial collateral ligament ( MCL ) is a broad , thick band that runs down the inner part of the knee , from the femur ( thighbone ) to about four to six inches from the top of the tibia ( shinbone ) .The MCL 's primary function is to prevent the leg from over-extending inward , but it also is part of the mechanism that stabilizes the knee and ...
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- A. Membrane receptors are peripheral, or associated with the surface of the bilayer. Association with a hormone results in the release of a lipid signal that activates protein kinases. B. Membrane receptors associated with signaling are all integral membrane proteins that can transmit signals through the lipid bilayer.
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Pancreatic Islets of Langerhans; Adrenal gland Delta cells make up 5% of the pancreatic cells in the Islets of Langerhans and are located variably in the area and release somatostatin, produce somatostatin, which acts within the islets of Langerhan to inhibit the production of both glucagon and insulin, slows GI motility, allowing more time for food to be absorbed.istology of Pancreatic Islets of Langerhans. 1-two million Islets in human 2- in the islets the cells are arranged in irregular chains and cords separated by a rich blood supply; 3- cells in islets: alpha cells (70%) secrete insulin and beta cells(20%) secrete glucagon.
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Use Guided Access with iPhone, iPad, and iPod touch Use Guided Access with iPhone, iPad, and iPod touch. Guided Access helps you to stay focused on a task while using your iPhone, iPad or iPod touch. Guided Access limits your device to a single app and lets you control which app features are available. You can use Guided Access to: Temporarily restrict your iOS device to a single app.
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- Second region –that generates a signal when the hormone binds to it. The dual function of binding and coupling (signal generation) ultimately defines a receptor. It is the coupling of hormone binding to signal transduction called, receptor – effector coupling.This is the first step in the amplification of hormonal response. This dual purpose also distinguishes the receptor from the plasma protein that also bind hormone but do not generate signal.Chemical Nature of Receptor. Receptors are proteins. Several classes of peptide receptors have been identified.ormone –receptor interaction occurs that results in the generation of an intracellular signal. Intracellular signal can either regulate the activity of a select set of genes, leading to alteration in the amount of certain proteins in the target cell.
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Autonomic Receptors Somatic muscle nicotinic receptors, (NM) are receptors for which prototype agonists include nicotine, and ACh. Phenyltrimethylammonium (PTMA) is a selective agonist. The classical antagonist of the NM receptor is the non-depolarizing neuromuscular junction blocker, d-tubocurarine (Tubarine®).omatic muscle nicotinic receptors, (NM) are receptors for which prototype agonists include nicotine, and ACh. Phenyltrimethylammonium (PTMA) is a selective agonist. The classical antagonist of the NM receptor is the non-depolarizing neuromuscular junction blocker, d-tubocurarine (Tubarine®).
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Sandostatin What is octreotide (Sandostatin, Sandostatin LAR Depot)? Octreotide is a man-made protein that is similar to a hormone in the body called somatostatin. Octreotide lowers many substances in the body such as insulin and glucagon (involved in regulating blood sugar), growth hormone, and chemicals that affect digestion. Octreotide is used to treat acromegaly. Octreotide is also used to reduce flushing episodes and watery diarrhea caused by cancerous tumors (carcinoid syndrome) or tumors called vasoactive intestinal peptide tumors (VIP adenomas).
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- Hormones, though, only bind to certain, compatible receptor types. Thyroid hormones and each steroid hormone group-the estrogens, androgens, progestins, glucocorticoids (stress hormones), and mineralocorticoids (water and ion-regulating hormones) - have a matching hormone receptor type. Once inside a target cell, the hormone (pink) binds to a receptor (purple) - similar to a hand sliding in a glove or mitten-and forms what is known as a hormone-receptor complex between the ligand and receptor.
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CrystalGraphicsAdvanced Sign Out Sign Out Sign InWidescreenSearch Our PowerPlugs Templates Annual Subscription allows you to download an unlimited number of PowerPlugs-brand templates at any time during the next 12 months. Over 32,000 PowerPlugs templates to choose from! Please note: Our Crystal-brand PowerPoint templates (those are the ones with the name Crystal in the image, such as the one to the left) are not included in this subscription.
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South Hamilton, Massachusetts (March 2010) South Hamilton is not a town or a neighborhood. It is a postal address assigned to ZIP code 01982 by the Postal Service and is indistinguishable geographically from the town of Hamilton, Essex County, Massachusetts, United States (ZIP code 01936).
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EGFR epidermal growth factor receptor [ (human)] Tocris Summary for ERBB2 Gene. The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain.ocris Summary for ERBB2 Gene. The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
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Estrogen receptor Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen. Two classes of ER exist: nuclear estrogen receptors, which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors, which are mostly G protein-coupled receptors. This article refers to the former. Once activated by estrogen, the ER is able to translocate into the nucleus and bind to DNA to regulate the activity of different g
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Octreotide Since octreotide resembles somatostatin in physiological activities, it can: 1  inhibit secretion of many hormones, such as gastrin, cholecystokinin, glucagon, growth hormone, insulin, secretin, pancreatic polypeptide, TSH, and vasoactive intestinal peptide,  reduce secretion of fluids by the intestine and pancreas,
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Steroid and Thyroid Hormone Receptors Thyroid hormones act by binding to cytosolic receptors of the steroid-thyroid hormone receptor superfamily (nuclear receptors) identified as thyroid hormone receptors (TR). There are two TR receptors designated TRα and TRβ encoded by the THRA and THRB genes, respectively.ynthesis of the male sex hormones in Leydig cells of the testis. P450SSC, 3β-DH, and P450c17 are the same enzymes as those needed for adrenal steroid hormone synthesis. 17,20-lyase is the same activity of CYP17A1 described above for adrenal hormone synthesis.
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Insulin receptor The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors.
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endocrine pancreas The somatostatin produced by the delta cells of the pancreas is the same as that produced by the hypothalamus as an inhibitor of the release of growth hormone from the pituitary gland.
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T-cell receptor The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
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- The consequence of growth hormone-releasing hormone action is an increase in the circulating levels of growth hormone and insulin-like growth factor 1 which, in turn, act back on the hypothalamus to prevent growth hormone-releasing hormone production and to stimulate somatostatin secretion.
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Fas receptor From Wikipedia, the free encyclopedia. The FAS receptor (FasR), also known as apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6) is a protein that in humans is encoded by the TNFRSF6 gene.revious reports have identified as many as eight splice variants, which are translated into seven isoforms of the protein. Apoptosis-inducing Fas receptor is dubbed isoform 1 and is a type 1 transmembrane protein. Many of the other isoforms are rare haplotypes that are usually associated with a state of disease.
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Sandostatin What is octreotide? Sandostatin (octreotide) is a man-made protein that is similar to a hormone in the body called somatostatin. Octreotide lowers many substances in the body such as insulin and glucagon (involved in regulating blood sugar), growth hormone, and chemicals that affect digestion. Sandostatin is used to treat acromegaly.