what is invokana used for?
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Canagliflozin (Redirected from Invokana) Canagliflozin (INN, trade name Invokana or Sulisent) is a drug of the gliflozin class or subtype 2 sodium-glucose transport (SGLT-2) inhibitors used for the treatment of type 2 diabetes. It was developed by Mitsubishi Tanabe Pharma and is marketed under license by Janssen, a division of Johnson & Johnson.
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FDA: Diabetes Drug Invokana Can Cause Too Much Acid in Blood The FDA first approved Invokana as the first SGLT2 drug in March 2013. Since then, it has become a cash cow for J&J and its Janssen Pharmaceuticals unit. In the first quarter of 2015, the drug already brought in $278 million, triple what it made last year.
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- Our Invokana (canagliflozin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
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Home The most common side effects of INVOKANA ® include: vaginal yeast infections and yeast infections of the penis; changes in urination, including urgent need to urinate more often, in larger amounts, or at night.
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- What is Invokana? Invokana (canagliflozin) is an oral diabetes medicine that helps control blood sugar levels. Canagliflozin works by helping the kidneys get rid of glucose from your bloodstream. Invokana is used together with diet and exercise to treat type 2 diabetes. Invokana is not for treating type 1 diabetes.
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- On Sept 10, 2015, the FDA issued a Safety Alert for Invokana and Invokamet, stating that Bone fractures have been seen in patients taking the type 2 diabetes medicine canagliflozin [Invokana].Fractures can occur as early as 12 weeks after starting canagliflozin.
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New Diabetes Drug Invokana Has Major Treatment - And Market - Potential Invokana was found in trials to raise cholesterol, both LDL or bad cholesterol and HDL, or “good” cholesterol. An elevated risk of stroke and heart attack was found in the first 30 days after starting the medication, but after 30 days Invokana reduced these risks.
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- The most serious potential side effects and risks caused by Invokana are myocardial infarction (heart attack), kidney damage and ketoacidosis. Kidney failure occurs when your kidneys stop functioning without the use of dialysis or a kidney transplant. Kidneys help filter waste products from the blood.
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IMPORTANT SAFETY INFORMATION for INVOKANAÂ®, INVOKAMETÂ® (canagliflozin/metformin HCl), and INVOKAMETÂ® XR (canagliflozin/metformin HCl extended-release) Overall, amputations of the toe and mid-foot were the most frequent (99 out of 140 patients with amputations receiving canagliflozin in the two trials); however, amputations involving the leg, below and above the knee, were also observed (41 out of 140 patients with amputations receiving canagliflozin in the two trials).
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- In May 2017, the FDA added a black box warning for an increased risk of leg and foot amputations with Invokana, Invokamet and Invokamet XR. The FDA’s decision came after it reviewed the results of two large clinical trials, the Canagliflozin Cardiovascular Assessment Study (CANVAS) and A Study of the Effects of Canagliflozin on Renal Endpoints in Adult Participants with Type 2 Diabetes Mellitus (CANVAS-A).
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Farxiga / Jardiance / Invokana: Ketoacidosis and Kidney Failure In May 2015 the FDA had announced it was investigating a association between Farxiga, Jardiance, and Invokana with diabetic ketoacidosis (DKA), ketoacidosis, or ketosis. See: “FDA Drug Safety Communication: FDA warns that SGLT2 inhibitors for diabetes may result in a serious condition of too much acid in the blood”.
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New Long-Term Data Show INVOKANAÂ® (canagliflozin) Lowers Blood Glucose in Older Patients with Type 2 Diabetes Inadequately Controlled on Other Therapies 1 Yeast infection of the penis (balanitis or balanoposthitis). 2  Men who take Invokana may get a yeast infection of the skin around the penis. 3  Certain men who are not circumcised may have swelling of the penis that makes it difficult to pull back the skin around the tip of the penis.
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FDA Drug Safety Communication: FDA revises label of diabetes drug canagliflozin (Invokana, Invokamet) to include updates on bone fracture risk and new information on decreased bone mineral density The U.S. Food and Drug Administration (FDA) has strengthened the warning for the type 2 diabetes medicine canagliflozin (Invokana, Invokamet) related to the increased risk of bone fractures and added new information about decreased bone mineral density. Bone mineral density relates to the strength of a person’s bones.
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Farxiga In patients tolerating INVOKANA 100 mg once daily who have an eGFR of 60 mL/min/1.73 m2 or greater and require additional glycemic control, the dose can be increased to 300 mg once daily [see Warnings and Precautions (5.3), Clinical Pharmacology (12.2), and Patient Counseling Information (17)].
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Invokana Invokana is a prescription medication used to treat type 2 diabetes. It belongs to a group of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. Invokana lowers blood sugar by causing the kidneys to get rid of more glucose in the urine. This medication comes in tablet form.
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Invokana and Weight Loss However, this medicine can cause side effects in some people. Some of the common side effects of Invokana include increased urination, bladder infections, and yeast infections. There are also some side effects of Invokana which may not necessarily be a negative reaction for some people. For instance, weight loss is a possible Invokana side effect.
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- Canagliflozin, the active ingredient of INVOKANA, is chemically known as (1S)-1,5-anhydro-1-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hemihydrate and its molecular formula and weight are C24H25FO5S•1/2 H2O and 453.53, respectively.
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FDA: Diabetes Drug Invokana Can Cause Too Much Acid in Blood Currently, Invokana — manufactured by Johnson & Johnson’s Janssen subsidiary — is only approved by the U.S. Food and Drug Administration to treat Type 2 diabetes. But doctors may use any drug for off-label (non-approved) uses if the drug may help a patient.
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- Side Effects of Invokana. In clinical studies, people who took Invokana suffered a number of common side effects. Researchers gathered data from 1,667 patients with Type 2 diabetes who took Invokana for about 24 weeks. The average age was 56 years and about 2 percent were older than 75.
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- Canagliflozin (Invokana) is an expensive drug used to treat type 2 diabetes. It helps to control blood sugar. This drug is more popular than comparable drugs. There are currently no generic alternatives to Invokana. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The lowest GoodRx price for the most common version of Invokana is around $443.88, 13% off the average retail price of $515.45. Compare SGLT2 inhibitors.
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IMPORTANT SAFETY INFORMATION for INVOKANAÂ®, INVOKAMETÂ® (canagliflozin/metformin HCl), and INVOKAMETÂ® XR (canagliflozin/metformin HCl extended-release) INDICATION AND USAGE. INVOKANA® (canagliflozin) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. INVOKANA® is not recommended in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.
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important safety information Men who take INVOKANA® may get a yeast infection of the skin around the penis. Symptoms include: redness, itching, or swelling of the penis; rash of the penis; foul-smelling discharge from the penis; or pain in the skin around penis.
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Need help paying for your INVOKANAÂ® (canagliflozin) prescription? WHAT IS INVOKANA®? INVOKANA® is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. INVOKANA® is not for people with type 1 diabetes or with diabetic ketoacidosis (increased ketones in blood or urine).
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- Invokana (canagliflozin) is one of several drugs that belong to a new class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. Normally, when a person eats the body produces insulin to process sugar that enters the body.