what is durvalumab
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Clinical trial of Durvalumab in GBM What is Durvalumab? Durvalumab is an investigational human monoclonal antibody directed against the programmed cell death ligand 1 (PD-L1) protein. Signals from PD-L1 help tumours avoid detection by the immune system. Durvalumab blocks these signals, countering the tumour’s immune-evading tactics. The antibody belongs to an emerging class of immunotherapies commonly referred to as checkpoint inhibitors, because they remove checks the body places on immune activation.
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Study tests safety, efficacy of pembrolizumab and Y90 in locally advanced hepatocellular carcinoma Pembrolizumab is a type of immunotherapy that works by removing the brakes on the immune system, which then allows the immune system to fight the cancer. Y90, also known as TheraSphere®, is one form of local radiation treatment that is delivered though a catheter into the liver.
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- A: Avastin (bevacizumab) is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body. It is used to treat a certain type of brain tumor as well as cancers of the kidney, colon, rectum, lung, or breast, usually as part of a combination of cancer medicines. Common side effects of Avastin include diarrhea, stomach pain, loss of appetite, dry mouth, increased thirst, dizziness, and hair loss.
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Drugs Rifampin is an antibacterial prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of tuberculosis (TB). Rifampin is also FDA-approved to treat people who have the bacterium Neisseria meningitidis but have no symptoms as a way to eliminate the bacterium from their noses and throats. (The bacterium Neisseria meningitidis can cause a serious infection called meningitis.) TB is an opportunistic infection.
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- 60 to 89 mL/min), moderate renal impairment (CLcr 30 to 59 mL/min), mild hepatic impairment. (bilirubin less than or equal to ULN and AST greater than ULN or bilirubin greater than 1.0 to 1.5 times. ULN and any AST), or ECOG performance status had no clinically significant effect on the. pharmacokinetics of durvalumab.
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- Multi-drug-resistant tuberculosis (MDR-TB) is defined as a form of TB infection caused by bacteria that are resistant to treatment with at least two of the most powerful first-line anti-TB drugs, isoniazid (INH) and rifampicin (RMP).sually, multidrug-resistant tuberculosis can be cured with long treatments of second-line drugs, but these are more expensive than first-line drugs and have more adverse effects. The treatment and prognosis of MDR-TB are much more akin to those for cancer than to those for infection.
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Kind History, Family Crest & Coats of Arms The name Kind was brought to England in the wave of migration that followed the Norman Conquest of 1066. The Kind family lived in Kinder, Derbyshire. The surname of Kinder was a local name which means of Kinder, a hamlet in the parish of Glossop, Derbyshire, near Chapel-en-le-Frith. PDF Coat of Arms.
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pertuzumab Pertuzumab is an intravenous drug that is used to treat breast cancer that has spread beyond the breast (metastasized). It belongs to a class of drugs called monoclonal antibodies. Other monoclonal antibodies used for treating breast cancer include trastuzumab (Herceptin) and ado-trastuzumab emtansine (Kadcyla).
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Tuberculosis (TB) Treatment of drug-resistant tuberculosis. Resistance to tuberculosis (TB) drugs is a formidable obstacle to effective TB care and prevention globally. Multidrug-resistant TB (MDR-TB) is multifactorial and fuelled by improper treatment of patients, poor management of supply and quality of drugs, and airborne transmission of bacteria in public places.
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Verastem Announces Regulatory Strategy for Duvelisib New Drug Application Following Guidance from FDA Verastem, Inc. (NASDAQ: VSTM), focused on discovering and developing drugs to improve the survival and quality of life of patients with cancer, today Verastem, Inc. (NASDAQ: VSTM), focused on discovering and developing drugs to improve the survival and quality of life of patients with cancer, today Verastem Announces Regulatory Strategy for Duvelisib New Drug Application Following Guidance from FDA
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- Use of Myrbetriq. Myrbetriq® (mirabegron) is a prescription medicine for adults used to treat overactive bladder (OAB) with symptoms of urgency, frequency and leakage. Important Safety Information. Myrbetriq is not for everyone. Do not use Myrbetriq if you have an allergy to mirabegron or any ingredients in Myrbetriq.
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Generic Coumadin Coumadin ® (warfarin sodium) is a prescription anticoagulant medication used to prevent and treat blood clots. It is known as a narrow therapeutic index medication, which means that there is little difference between the effective dosing range and the toxic dosing range.pecial care must be taken when using generic versions of such medications. Coumadin is manufactured by Bristol-Myers Squibb Company. The patents for the drug have long expired, and generic Coumadin is now available.
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Angiomax What is Angiomax (bivalirudin)? Bivalirudin is an anticoagulant (thrombin inhibitor) that helps prevent the formation of blood clots. An unwanted blood clot can occur with certain heart or blood vessel conditions. Bivalirudin is used to prevent blood clots in people with severe chest pain or other conditions who are undergoing a procedure called angioplasty (to open blocked arteries).
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Glossary It is a monoclonal antibody that binds to the CD38 molecule found on the surface of multiple myeloma cells, signalling the immune system to kill these cells. Daratumumab may be useful in fighting other blood-related cancers, including certain lymphomas and leukemias, as the CD38 is also expressed on these cells.t has been granted Breakthrough Therapy Designation by the FDA (an accelerated review process) in the treatment of multiple myeloma.
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What is multidrug-resistant tuberculosis (MDR-TB) and how do we control it? A: The bacteria that cause tuberculosis (TB) can develop resistance to the antimicrobial drugs used to cure the disease. Multidrug-resistant tuberculosis (MDR-TB) is TB that does not respond to at least isoniazid and rifampicin, the two most powerful anti-TB drugs.The reasons why multidrug resistance continues to emerge and spread are mismanagement of TB treatment and person-to-person transmission.ultidrug-resistant tuberculosis (MDR-TB) is TB that does not respond to at least isoniazid and rifampicin, the two most powerful anti-TB drugs. The reasons why multidrug resistance continues to emerge and spread are mismanagement of TB treatment and person-to-person transmission.
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Tuberculosis (TB) in pregnancy Tuberculosis (or TB) is a contagious infection caused by Mycobacterium tuberculosis. Most often it infects the lungs, but it can also attack other parts of the body, such as the spine, kidneys and brain. Tuberculosis has two stages, TB infection and TB disease: Someone infected with TB who doesn't have TB disease can't spread the bacteria to others, but should be treated to prevent the development of the disease. The BCG vaccine is effective in protecting children against serious TB disease, but studies show that it provides protection for up to 15 years.
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Mycobacterium tuberculosis Extensively drug-resistant TB (XDR TB) is a rare type of multidrug-resistant tuberculosis (MDR TB) that is resistant to isoniazid and rifampin, plus any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin).rug-resistant TB (MDR or XDR) is more common in people who: 1  Do not take their TB medicine regularly. 2  Do not take all of their TB medicines as prescribed by their doctor. 3  Develop TB disease again, after having taken TB medicine in the past.
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- Bevacizumab (pronounced /bev-a-Sizz-uh-mab/, trade name Avastin, Genentech / Roche) is an angiogenesis inhibitor, a drug that slows the growth of new blood vessels.
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Verastem's blood cancer drug succeeds in late-stage trial Verastem will begin a mid-stage trial testing duvelisib to treat Peripheral T-Cell Lymphoma (PTCL) by the end of the year in the United States and Japan, the company added. PTCL, which affects the elderly, is a rare, aggressive cancer of mature white blood cells that manifests as widespread, painless lymph nodes in the neck, armpit or groin.
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Warfarin What is COUMADIN? Coumadin is a prescription medicine used to treat blood clots and to lower the chance of blood clots forming in your body. Blood clots can cause a stroke, heart attack, or other serious conditions if they form in the legs or lungs.
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Vincasar PFS Vincristine is cancer medication that interferes with the growth of cancer cells and slows their spread in the body. Vincristine is used to treat leukemia, Hodgkin's disease, non-Hodgkin's lymphoma, rhabdomyosarcoma (soft tissue tumors), neuroblastoma (cancer that forms in nerve tissue), and Wilms' tumor. Vincristine is sometimes used in combination with other cancer medications.
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Rituximab (Rituxan and MabThera) Rituximab (Rituxan and MabThera) is a drug used to treat rheumatoid arthritis that has not improved with other types of medications, as well as certain forms of vasculitis. It works by turning off a part of the immune system that is not working properly in autoimmune diseases.
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- Siltuximab ( INN , trade name Sylvant ; also known as CNTO 328, anti-IL-6 chimeric monoclonal antibody or cCLB8) is a chimeric (made from human and mouse proteins ) monoclonal antibody . It binds to interleukin-6 .
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Explore the injection experience SIMPONI Â® has to offer SIMPONI ARIA® (golimumab) is a prescription medicine. SIMPONI ARIA® can lower your ability to fight infections. There are reports of serious infections caused by bacteria, fungi, or viruses that have spread throughout the body, including tuberculosis (TB) and histoplasmosis. Some of these infections have been fatal.
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Mantoux test Mantoux test. The Mantoux test or Mendel-Mantoux test (also known as the Mantoux screening test, tuberculin sensitivity test, Pirquet test, or PPD test for purified protein derivative) is a tool for screening for tuberculosis (TB) and for tuberculosis diagnosis.
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Biological Therapies for Cancer Aldesleukin, IL-2 that is made in a laboratory, has been approved for the treatment of metastatic kidney cancer and metastatic melanoma. Researchers are currently investigating whether combining aldesleukin treatment with other types of biological therapies may enhance its anticancer effects.ncolytic virus therapy is an experimental form of biological therapy that involves the direct destruction of cancer cells. Oncolytic viruses infect both cancer and normal cells, but they have little effect on normal cells.