what is bisphosphonate
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Bisphosphonates Bisphosphonates are a group of medicines used to treat conditions that affect your bones. Different bisphosphonates are available for different conditions. Bisphosphonates are a group of medicines used to treat conditions that affect your bones.
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Emory University School of Medicine Department of Pediatrics Bisphenol A is a chemical compound used to manufacture polycarbonate plastic and epoxy resins. Polycarbonate plastic and epoxy resins are used as linings on many consumer products and used in the manufacture of flame retardants, so Bisphenol A is one of the most widely used chemicals worldwide.isphenol A is a chemical compound used to manufacture polycarbonate plastic and epoxy resins. Polycarbonate plastic and epoxy resins are used as linings on many consumer products and used in the manufacture of flame retardants, so Bisphenol A is one of the most widely used chemicals worldwide.
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Boniva For Patients. Boniva (ibandronate) is a bisphosphonate drug that alters the cycle of bone formation and breakdown in the body used to treat or prevent osteoporosis in women after menopause. Boniva slows bone loss while increasing bone mass, which may prevent bone fractures. Side effects of Boniva include: back pain,
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Diagnosis For both men and women at increased risk of fracture, the most widely prescribed osteoporosis medications are bisphosphonates. Examples include: Alendronate (Fosamax) Risedronate (Actonel, Atelvia) Ibandronate (Boniva) Zoledronic acid (Reclast) Side effects include nausea, abdominal pain and heartburn-like symptoms. These are less likely to occur if the medicine is taken properly. Intravenous forms of bisphosphonates don't cause stomach upset but can cause fever, headache and muscle aches for up to three days.
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- Calcium phosphate is the principal form of calcium found in bovine milk and blood. Seventy percent of bone consists of hydroxyapatite, a calcium phosphate mineral (known as bone mineral). Biphasic calcium phosphate (not to be confused with dibasic calcium phosphate) is a biomaterial that is biphasic, consisting of a mixture of tricalcium phosphate and hydroxyapatite. 2  It is an alternative to bone grafting that is used around osseous implants (such as dental implants).
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Breast Cancer: Treatment Options A: Fosamax (alendronate) is in a drug class called bisphosphonates. Fosamax is used to prevent and treat osteoporosis (thinning and weakening of bones which may cause them to break easily) in women who have been through menopause. Fosamax is also used to treat osteoporosis in men.
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- Pharmacotherapy is recommended for men with osteoporosis and for high-risk men with low bone mass (osteopenia) with a T-score of −1 to −2.5. Bisphosphonates are the first-line agents for treating osteoporosis in men.
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Understanding the Phosphonate Products Phosphonate compounds also occur naturally in some lower life forms, including protozoa, mollusks, coelenterates, and oomycete fungi (6). For this article, we use the term phosphonate to describe only those products made up of the salts and esters of phosphorous acid (HPO(OH) 2 ). Phosphorous acid is a solid substance that can be purchased through chemical supply companies. When mixed with water, it forms a strong acid called phosphonic acid.
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Phosphonate Phosphonates are effective chelating agents. That is, they bind tightly to di-and trivalent metal ions, which is useful in water softening. In this way, they prevent formation of insoluble precipitates (scale). The binding of these ligands also suppresses the catalytic properties of metal ions.ince the work of Schwarzenbach in 1949, phosphonic acids are known as effective chelating agents. The introduction of an amine group into the molecule to obtain-NH 2 -C-PO(OH) 2 increases the metal binding abilities of the phosphonate. Examples for such compounds are NTMP, EDTMP and DTPMP.
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Fosamax DRUG DESCRIPTION. FOSAMAX (alendronate sodium) is a bisphosphonate that acts as a specific inhibitor of osteoclastmediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.et emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using alendronate and call your doctor at once if you have a serious side effect such as: 1  chest pain;
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Prolia, the New Darling in the Treatment of Osteoporosis Differently from the bisphosphonates. Prolia is what is called a monoclonal antibody (hint, a medication whose generic name ends in -mab is a monoclonal antibody). Prolia inhibits the activation of osteoclasts which break down bone.
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What is BPA and Why is it Bad for You? BPA (bisphenol-A) is a chemical that is added to many commercial products, including food containers and hygiene products. It was first discovered in the 1890s, but chemists in the 1950s realized that it could be mixed with other compounds to produce strong and resilient polycarbonate plastics.
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Bisphosphonate Side Effects Rare, but serious side effects include: Kidney problems; Osteonecrosis of the jaw (damage to the jawbone) Unusual types of bone fractures; Kidney problems have been seen in patients taking intravenously administered bisphosphonates for long periods of time. The risk of kidney problems may be increased in patients who are taking other drugs that affect the kidney (e.g. Thalomid, non-steroidal anti-inflammatory drugs also known as NSAIDs) or have other conditions associated with kidney problems such as hypertension or diabetes mellitus.
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Bisphosphonates Now, as of June 11, 2014 the FDA has approved the first generic risedronate—and you’ll be able to find it on pharmacy shelves this month. The medications widely used for the treatment and prevention of osteoporosis are the bisphosphonates: Boniva (ibandronate), Fosamax (alendronate) and Actonel (risedronate).
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- Bisphosphonates are commonly prescribed for treatment of osteoporosis. Long-term use of bisphosphonates has been correlated to atypical femoral fractures (AFF). AFFs arise from fatigue damage to bone ... Role of bone-anabolic agents in the treatment of breast cancer bone metastases.
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Alendronate Alendronate works by slowing bone loss. This effect helps maintain strong bones and reduce the risk of broken bones (fractures). Alendronate belongs to a class of drugs called bisphosphonates. Alendronate is available under the following different brand names: Fosamax, Binosto, and Fosamax Plus D. Dosages of Alendronate: Dosage Forms and Strengths. Tablet
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- Knowledge center. Bisphenol A, often known as BPA is a chemical found in hard plastics and the coatings of food and drinks cans which can behave in a similar way to estrogen and other hormones in the human body.PA can also be found in epoxy resins which is used as coatings inside food and drinks cans. Bisphenol A is an endocrine disruptor-a substance which interferes with the production, secretion, transport, action, function and elimination of natural hormones.
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Osteoporosis - Overview Oral bisphosphonates. These pills include alendronate (Fosamax, generic), risedronate (Actonel, generic), and ibandronate (Boniva, generic). Alendronate and risedronate are taken once a week. Ibandronate is available as a once-monthly pill. Risedronate is also available as a once-a-month pill and in a pill that contains calcium. Alendronate is available in a formulation that has vitamin D. Risedronate and alendronate are approved for both men and women.
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risedronate (Actonel, Atelvia) What is risedronate (Actonel)? Risedronate is in a group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Risedronate slows bone loss while increasing bone mass, which may prevent bone fractures. Risedronate is used to treat or prevent osteoporosis in men and women.
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Bisphenol S Bisphenol S (BPS) is an organic compound with the formula (HOC 6 H 4) 2 SO 2. It has two phenol functional groups on either side of a sulfonyl group.It is commonly used in curing fast-drying epoxy resin adhesives.It is a bisphenol, and a close analog of bisphenol A (BPA) in which the dimethylmethylene group (C(CH 3) 2) is replaced with a sulfone group (SO 2).isphenol S (BPS) is an organic compound with the formula (HOC 6 H 4) 2 SO 2. It has two phenol functional groups on either side of a sulfonyl group.
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Fosamax DRUG DESCRIPTION. FOSAMAX (alendronate sodium) is a bisphosphonate that acts as a specific inhibitor of osteoclastmediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.top using alendronate and call your doctor at once if you have a serious side effect such as: 1  chest pain; 2  difficulty or pain when swallowing; 3  pain or burning under the ribs or in the back; 4  severe heartburn, burning pain in your upper stomach, or coughing up blood;
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- Well the Leicestershire County Council Pension Fund does not pay any increase on Pre 88 GMP, the increase due on any GMP relating to service prior to 6th April 1988 will be paid with your State Pension by the Department of Work and Pensions (DWP).ny increase over 3% will be paid along with your State Pension by the Department of Work and Pensions (DWP). The remainder of your pension, after the setting aside of the GMP components, will be increased by the annual increase rate, e.g. 2.2% for 2013.
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Bisphosphonates: How Long Is Enough? Bisphosphonates were first approved in the US for the treatment and prevention of osteoporosis in 1995. These drugs exert their beneficial actions through a combination of physical and biochemical actions. Notably, bisphosphonates bind to hydroxyapatite in bone, where they are incorporated into the mineral matrix.
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alendronate (Binosto, Fosamax) Fosamax (alendronate) belongs to a group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Fosamax is used in women to treat or prevent osteoporosis that is caused by menopause and in men and women to treat osteoporosis caused by taking steroids. Fosamax is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women.
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- 504403164031640FDA Urges Caution Over Long-Term Use of Bone-Density DrugsMillions of women grapple with whether to take bone-density-building drugs to treat or prevent osteoporosis, but the FDA this week warned that long-term use of bisphosphonates can lead to rare fractures and side effects.
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Medication-associated osteonecrosis of the jaw There is no known prevention for bisphosphonate-associated osteonecrosis of the jaw. Avoiding the use of bisphosphonates is not a viable preventive strategy on a general-population basis because the medications are beneficial in the treatment and prevention of osteoporosis (including prevention of bony fractures) and treatment of bone cancers.