genetics of autoimmune diseases
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Inheritance and Genetics of Autoimmune diseases Autoimmune diseases: Genetics Information. Genetics of Autoimmune diseases: Autoimmune diseases also seem to have a genetic component, but, mysteriously, they can cluster in families as different illnesses. For example, a mother may have lupus erythematosus; her daughter, diabetes; her grandmother, rheumatoid arthritis.
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- Common autoimmune diseases include celiac disease, rheumatoid arthritis, multiple sclerosis and type 1 diabetes. Normally, your body's immune system manufactures molecules called antibodies that are designed to fight invaders such as viruses that can make you sick.
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Autoimmune lymphoproliferative syndrome Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). ALPS is characterized by the production of an abnormally large number of lymphocytes (lymphoproliferation).
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Autoimmune regulator In the thymus, the autoimmune regulator causes transcription of a wide selection of organ-specific genes that create proteins that are usually only expressed in peripheral tissues, creating an immunological self-shadow in the thymus.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
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Inheritance of Autosomal Recessive Genetic Diseases Inheritance of Autosomal Recessive Genetic Diseases. These genetic diseases are diseases caused by an error in a single DNA gene. Autosomal means the errors occurs on chromosome 1..22 rather than on the 23rd sex-linked X chromosome.Recessive means that disease only occurs when a person has two copies of the bad gene.Usually this means they must inherit the disease from both parents. Some examples of autosomal recessive diseases are Cystic Fibrosis, Phenylketonuria, Sickle Cell Anemia, Tay Sachs, Albinism, and galactosemia.See autosomal recessive diseases for a full list.Recessive diseases often occur in genes that produce an enzyme. In a carrier, who has only one bad copy, there is often no disease, because the second gene can pull up the slack, and maintain health. In some recessive diseases, a carrier gets a mild form of the disease.ecessive means that disease only occurs when a person has two copies of the bad gene. Usually this means they must inherit the disease from both parents. Some examples of autosomal recessive diseases are Cystic Fibrosis, Phenylketonuria, Sickle Cell Anemia, Tay Sachs, Albinism, and galactosemia.
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- A. Autoimmune diseases usually do not usually have a simple, single cause. There are usually two major factors that are involved in causing them: genetics and environment. Genetics-Even with a genetic connection to autoimmune disease, there is no guarantee that you will develop an autoimmune disease. Something must turn on your immune system to trigger an autoimmune response. Environment-Environmental factors make up more than half the risk of developing an autoimmune disease. We know that certain environmental substances can trigger autoimmune disease. For example, silica can trigger scleroderma; certain drugs can trigger lupus; and, in some women, pregnancy can trigger an autoimmune disease. For more information: http://www.aarda.org/modules.php.
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- Autoimmune thyroid diseases are generally hereditary in origin, although environmental factors, such as infection, certain drugs, and iodine consumption, can play a role in their progression. Autoimmune thyroiditis is more common in women than in men, and it primarily affects people between 40 and 60 years of age.hile chronic autoimmune thyroid diseases are generally mild or even symptomless, they can progress to significant hypothyroidism. Seek prompt medical care for worrisome symptoms of hypothyroidism, such as depression or unexplained weight gain. 1  Previous. 2  1. 3  2. 4  3. 5  Next.
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- Many, if not most autoimmune diseases, have a genetic or hereditary basis. This means that if you have a family member with an autoimmune disease, you are at an increased risk of developing an autoimmune condition as well.
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- Pompe disease is caused by mutation of the acid alpha-glucosidase gene (GAA) gene. More than 100 different mutations in the GAA gene have been identified in families with this disorder. Mutations of the GAA gene in Pompe disease are inherited as an autosomal recessive trait.
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Associated Autoimmune Disorders, Conditions, and Cancers Celiac Disease Foundation. Associated Autoimmune Disorders, Conditions, and Cancers. Celiac disease is an autoimmune disorder. People with one autoimmune disorder are prone to getting other autoimmune disorders. For people with celiac disease, the later the age of diagnosis, the greater the chance of developing another autoimmune disorder. Other serious conditions and some cancers are also associated with celiac disease, though following a strict, gluten-free diet may decrease cancer risk.
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Autoimmune Disorders AUTOIMMUNE DISORDERS. Vitiligo. Vitiligo is a condition in which your skin loses melanin, the pigment that determines the color of your skin, hair and eyes. Vitiligo occurs when the cells that produce melanin die or no longer form melanin, causing slowly enlarging white patches of irregular shapes to appear on your skin.
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- A large number of autoimmune diseases are recognized. A major understanding of the underlying pathophysiology of autoimmune diseases has been the application of genome wide association scans that have identified a striking degree of genetic sharing among the autoimmune diseases.
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Inheritance of Autosomal Recessive Genetic Diseases These genetic diseases are diseases caused by an error in a single DNA gene. Autosomal means the errors occurs on chromosome 1..22 rather than on the 23rd sex-linked X chromosome. Recessive means that disease only occurs when a person has two copies of the bad gene.Usually this means they must inherit the disease from both parents. Some examples of autosomal recessive diseases are Cystic Fibrosis, Phenylketonuria, Sickle Cell Anemia, Tay Sachs, Albinism, and galactosemia.ecessive diseases often occur in genes that produce an enzyme. In a carrier, who has only one bad copy, there is often no disease, because the second gene can pull up the slack, and maintain health. In some recessive diseases, a carrier gets a mild form of the disease.
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- Genetics[edit] “Thyroid autoimmunity is familial.” The disease is said to be inherited as a dominant trait since it has been reported that as many as fifty percent of the first degree relatives of patients with some type of autoimmune thyroiditis present thyroid antibodies in serum.
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- The development of an autoimmune disease may be influenced by the genes a person inherits together with the way the person's immune system responds to certain triggers or environmental influences.
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Alzheimer's Disease Genetics Fact Sheet If a person inherits from a parent a genetic mutation that causes a certain disease, then he or she will usually get the disease. Sickle cell anemia, cystic fibrosis, and early-onset familial Alzheimer's disease are examples of inherited genetic disorders.In other diseases, a genetic variant may occur. Genetic mutation— A permanent change in a gene that can be passed on to children. 2  The rare, early-onset familial form of Alzheimer's disease is associated with mutations in genes on chromosomes 21, 14, and 1. 3  Genetic risk factor— A change in a gene that increases a person's risk of developing a disease.
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Inheritance of Autosomoal Dominant Genetic Diseases Inheritance of Autosomoal Dominant Genetic Diseases. These genetic diseases are diseases caused by an error in a single DNA gene. Autosomal means the errors occurs on chromosome 1..22 rather than on the 23rd sex-linked X chromosome. There are also X-linked dominant genetic diseases affecting the 23rd X chromosome.Some examples of autosomal dominant diseases are Huntington's disease and achondroplasia (dwarfism).n dominant genetic diseases, the bad gene overcomes the good gene and disease occurs, whereas in recessive diseases the good gene is an adequate backup and recessive diseases do not occur unless both copies are damaged. But it is not always so black and white.
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Inheritance and Genetics of Autoimmune diseases About inheritance and genetics: Inheritance of Autoimmune diseases refers to whether the condition is inherited from your parents or runs in families. The level of inheritance of a condition depends on how important genetics are to the disease.
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New Genetic Insights from Autoimmune Thyroid Disease The autoimmune thyroid diseases (AITDs), Graves' disease and Hashimoto's thyroiditis, are typical examples of such complex diseases and have been recognized for many years as having an important genetic component.
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Autosomal Recessive Disease - Topic Overview Autosomal recessive diseases are genetic diseases that are passed to a child through both parents' chromosomes. Each person inherits 23 chromosomes from each parent and so has 23 pairs of chromosomes. Each chromosome contains genes. One or both of the chromosomes in a pair may contain a changed (mutated) gene that could cause a genetic disease. In an autosomal recessive disease, both chromosomes in a pair must have a changed gene for the person to have the disease. If only one chromosome has a changed gene, the person is a carrier and does not have symptoms.
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Autoimmune disease An example is Hashimoto's disease of the thyroid, characterized by a specific lesion in the thyroid gland with infiltration by mononuclear cells, destruction of follicular cells, and production of antibodies with absolute specificity for certain thyroid constituents.ome autoimmune disorders, such as Hashimoto's disease, are tissue specific, whereas others, such as SLE, affect multiple organs and systems. Both genetic and environmental triggers may contribute to autoimmune disease. About 5-8% of the U.S. population is affected by an autoimmune disease.
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Is Lupus a Genetic Disease? Lupus is a systemic autoimmune disease that has some genetic factors. It is also tied to environmental risk, which may determine whether people actually ever manifest the illness. These environmental factors may also play a role in the degree to which lupus may affect a person’s life and mortality.
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Autoimmune Diseases Autoimmune diseases are characterized by the body's immune responses being directed against its own tissues, causing prolonged inflammation and subsequent tissue destruction.uch diseases include, but are not limited to, celiac disease, Crohn's disease, pancreatitis, systemic lupus erythematosus, Sjogren's syndrome, Hashimoto's thyroiditis, and other endocrinopathies. Allergies and multiple sclerosis are also the result of disordered immune functioning. Life Extension Suggestions.
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Addisonâs Disease: Overview of Antibodies & Genetic Links Addison’s is believed to be mostly a genetically complex disease, which makes elucidating the mechanisms of inheritance more challenging. As with other autoimmune conditions, it is believed that this disorder involves a genetic predisposition that is somehow triggered, resulting in the ensuing autoimmune process.