what are underlying causes of scleroderma
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- Scleroderma is a group of diseases that affect connective tissue in the body. This tissue supports your skin and internal organs. Scleroderma involves tissue that gets hard or thick. It can also cause swelling or pain in the muscles and joints.Some types of scleroderma lead to hard, tight skin.cleroderma is a group of diseases that affect connective tissue in the body. This tissue supports your skin and internal organs. Scleroderma involves tissue that gets hard or thick. It can also cause swelling or pain in the muscles and joints.
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Amazon will donate 0.5% of your purchase to support NORD.Sign up today!Add NORD to Your Account The exact cause of lichen sclerosus is not known. It may be due to an autoimmune process, or an injury, or may follow radiation therapy. Autoimmune disorders arise when the body’s natural defenses against “foreign” or invading organisms (e.g., antibodies) begin to attack healthy tissue for unknown reasons.
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Is Scleroderma a terminal illness? Making the world better, one answer at a time. Yes. Scleroderma is a connective tissue disease that occurs due to excess collagen build up. It causes the skin, tissues, and internal organs to gradually harden and tighten over time.Consequently, it slowly kills its victim. It's a terrible illness.es. Scleroderma is a connective tissue disease that occurs due to excess collagen build up. It causes the skin, tissues, and internal organs to gradually harden and tighten over time. Consequently, it slowly kills its victim.
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Systemic scleroderma There is no clear obvious cause for scleroderma and systemic sclerosis. Genetic predisposition appears to be limited: genetic concordance is small; still, there often is a familial predisposition for autoimmune disease.Polymorphisms in COL1A2 and TGF-β1 may influence severity and development of the disease.here is no clear obvious cause for scleroderma and systemic sclerosis. Genetic predisposition appears to be limited: genetic concordance is small; still, there often is a familial predisposition for autoimmune disease.
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Raynaudâs Phenomenon There are many causes of secondary Raynaud’s phenomenon. These include changes to blood vessels or how the body controls blood flow. These changes can happen if you get another disease or become ill. For example, in scleroderma, the skin and finger blood vessels are narrowed by scarring in the blood vessel wall.
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Scleroderma Description Scleroderma is an autoimmune disorder, which means that the body's immune system turns against itself. In scleroderma, there is an overproduction of abnormal collagen (a type of protein fiber present in connective tissue).
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First Symptoms of Systemic Scleroderma Scleroderma is a condition in which a type of connective tissue in the body called collagen is overproduced. It can be localized, leading to hardened patches or bands of skin, the tissue that lies immediately below the skin and sometimes the muscles of the arms, legs or forehead. It can also be systemic--sometimes called systemic sclerosis--in which case the excess collagen has a more widespread effect.
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Scleroderma, a Rheumatic Disease and a Connective Tissue Disease Though it is often referred to as if it were a single disease, scleroderma is really a symptom of a group of diseases that involve the abnormal growth of connective tissue, which supports the skin and internal organs. In some forms of scleroderma, hard, tight skin is the extent of this abnormal process.
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Scleroderma Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs.[2][6] The disease can be either localized to the skin or involve other organs in addition to the skin.[2] Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes ...
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Systemic Sclerosis/Scleroderma: A Treatable Multisystem Disease Systemic sclerosis (systemic scleroderma) is a chronic connective tissue disease of unknown etiology that causes widespread microvascular damage and excessive deposition of collagen in the skin and internal organs. Raynaud phenomenon and scleroderma (hardening of the skin) are hallmarks of the disease.The typical patient is a young or middle-age woman with a history of Raynaud phenomenon who presents with skin induration and internal organ dysfunction.aynaud phenomenon and scleroderma (hardening of the skin) are hallmarks of the disease. The typical patient is a young or middle-age woman with a history of Raynaud phenomenon who presents with skin induration and internal organ dysfunction.
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Scleroderma 1 Scleroderma is a disease of the connective tissue featuring skin thickening that can involve scarring, blood vessel problems, varying degrees of inflammation, and is associated with an overactive immune system. 2  CREST syndrome is a limited form of systemic sclerosis.cleroderma is an autoimmune disease of the connective tissue characterized by skin thickening, spontaneous scarring, blood vessel disease, and varying degrees of inflammation, associated with an overactive immune system.
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Systemic scleroderma The signs and symptoms of systemic scleroderma usually begin with episodes of Raynaud phenomenon, which can occur weeks to years before fibrosis.In Raynaud phenomenon, the fingers and toes of affected individuals turn white or blue in response to cold temperature or other stresses.n addition, people with systemic scleroderma often have open sores (ulcers) on their fingers, painful bumps under the skin (calcinosis), or small clusters of enlarged blood vessels just under the skin (telangiectasia).
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Coffee Cup and Bomb Calorimetry A calorimeter is a device used to measure the quantity of heat flow in a chemical reaction. Two of the most common types of calorimeters are the coffee cup calorimeter and the bomb calorimeter.Coffee Cup Calorimeter. A coffee cup calorimeter is essentially a polystyrene (Styrofoam) cup with a lid.n a bomb calorimeter, the reaction takes place in a sealed metal container, which is placed in the water in an insulated container. Heat flow from the reaction crosses the walls of the sealed container to the water. The temperature difference of the water is measured, just as it was for a coffee cup calorimeter.
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Scleroderma Scleroderma is a poorly understood illness that causes widespread hardening of the skin, especially on the hands and face. It also can damage the lungs, heart, kidneys, digestive tract, muscles and joints.
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What is Scleroderma? Overview of Scleroderma. Mayo Clinic. Scleroderma is both a rheumatic disease and a connective tissue disease. The term rheumatic disease refers to a group of conditions characterized by inflammation and/or pain in the muscles, joints, or fibrous tissue.A connective tissue disease is one that affects tissues such as skin, tendons, and cartilage.NIAMS.ymptoms. Systemic Scleroderma Symptoms. Systemic sclerosis (scleroderma) can affect every part of the body, including the skin, blood vessels, and all of the internal organs. There are also dozens of associated conditions and related autoimmune diseases.
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Systemic Scleroderma Definition and etiology. Scleroderma, or systemic sclerosis (SSc), is a chronic multisystem autoimmune disease characterized by a vasculopathy, diffuse fibrosis of skin and various internal organs, and immune abnormalities.ystemic scleroderma always leads to some internal organ involvement. It is further divided into two subsets of disease, limited or diffuse (see Box 1). According to LeRoy and colleagues, limited or diffuse disease is based on the extent of skin tightening.
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Types of Scleroderma Scleroderma, also known as systemic sclerosis, is a chronic systemic autoimmune disease characterised by hardening (sclero) of the skin (derma). In the more severe form, it also affects internal organs. Limited scleroderma involves cutaneous manifestations that mainly affect the hands, arms and face.
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- Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
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- Scleroderma, a Greek word meaning hard skin, is a disease in which affected tissue hardens or thickens in response to the overproduction and accumulation of collagen, connective tissue that supports the skin and internal organs. Systemic scleroderma: With this type of scleroderma, blood vessels and internal organs in addition to the skin are affected. 2  Subcategories are defined by the specific body parts affected. 3  With systemic scleroderma, skin changes may develop suddenly and worsen progressively over a year or two.
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Scleroderma Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal thickening of the skin. Connective tissue is composed of collagen, which supports and binds other body tissues. There are several types of scleroderma.
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Raynaud's phenomenon Underlying diseases and disorders that can cause Raynaud's phenomenon include certain autoimmune disorders, such as scleroderma, systemic lupus erythematosus, and rheumatoid arthritis. If the cause is unknown, the condition is called Raynaud's disease or primary Raynaud's.
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- Systemic scleroderma is the most serious form of the disease, can affect the skin, muscles, joints, blood vessels, lungs, kidneys, heart and other organs. There are two major forms of systemic scleroderma: limited cutaneous systemic sclerosis (also called CREST syndrome) and diffuse cutaneous systemic scleroderma.
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The Lowdown on Lichen Sclerosus The cause is unknown, although an overactive immune system may play a role. Some people may have a genetic tendency toward the disease, and many studies suggest that abnormal hormone levels may also play a role. Some scientists believe that an infectious bacterium, called a spirochete, may cause the changes in the immune system that lead to Lichen Sclerosus. But the fact that most women that get LS are of menopausal age, and also have other auto-immune issues, seems to indicate there is a hormonal and auto-immune connection.
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Scleroderma Skin Involvement: Overview In the initial stages, the systemic forms of scleroderma may cause edema (swelling) in the fingers. Elbow Tip Pain. Scleroderma Elbow Tip Pains A common area of involvement of this condition is the skin over the tips of the elbows (the olecranon
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Systemic scleroderma Another early sign of systemic scleroderma is puffy or swollen hands before thickening and hardening of the skin due to fibrosis. Skin thickening usually occurs first in the fingers (called sclerodactyly) and may also involve the hands and face.n addition, people with systemic scleroderma often have open sores (ulcers) on their fingers, painful bumps under the skin (calcinosis), or small clusters of enlarged blood vessels just under the skin (telangiectasia).
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Scleroderma Overview Print. Scleroderma, also called systemic sclerosis (SSc), is a chronic autoimmune disease that can affect a number of body systems (i.e., a multisystemic disorder).he disease is more common in adults between the ages of 30 and 50, and is 3 to 5 times more common in women than men. Scleroderma also may affect children and the elderly. The diffuse (widespread) form of the disease occurs more often in African American women than in Caucasian women.