what is beta thalassemia
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Beta thalassemia Beta thalassemia is a blood disorder that reduces the production of hemoglobin. Hemoglobin is the iron-containing protein in red blood cells that carries oxygen to cells throughout the body.In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body.Affected individuals also have a shortage of red blood cells (anemia), which can cause pale skin, weakness, fatigue, and more serious complications.eta thalassemia is classified into two types depending on the severity of symptoms: thalassemia major (also known as Cooley's anemia) and thalassemia intermedia. Of the two types, thalassemia major is more severe. The signs and symptoms of thalassemia major appear within the first 2 years of life.
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Everything you need to know about thalassemia Iron deficiency anemia is a condition resulting from too little iron in the body which decreases the body’s ability to produce hemoglobin. Iron deficiency is the most common cause of anemia in the
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- Beta thalassemia is a fairly common blood disorder worldwide. Thousands of infants with beta thalassemia are born each year. Beta thalassemia occurs most frequently in people from Mediterranean countries, North Africa, the Middle East, India, Central Asia, and Southeast Asia.
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BETA-THALASSEMIA ▼ Description. Beta-thalassemia is characterized by a reduced production of hemoglobin A (HbA, alpha-2/beta-2), which results from the reduced synthesis of beta-globin chains relative to alpha-globin chains, thus causing an imbalance in globin chain production and hence abnormal erythropoiesis.
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Human Physiology/Print Version Thalassemia — a genetic disorder that causes low levels of hemoglobin and red blood cells; If you've been previously diagnosed with anemia, a hemoglobin level that's lower than normal may indicate a need to alter your treatment plan. Higher than normal results. If your hemoglobin level is higher than normal, it may be the result of:
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Thalassemia Thalassemia can only be diagnosed with blood tests. Doctors use several different types of blood tests to look for thalassemia. Some tests measure the number and size of red blood cells, or the amount of iron in the blood. Others look at the hemoglobin within the red blood cells.
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Thalassemia Hemoglobin is made of two proteins: Alpha globin and beta globin. Thalassemia occurs when there is a defect in a gene that helps control production of one of these proteins. Alpha thalassemia occurs when a gene or genes related to the alpha globin protein are missing or changed (mutated).
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What is Thalassemia? Alpha thalassemia results in an excess of beta globins, which leads to the formation of beta globin tetramers (β 4) called hemoglobin H. These tetramers are more stable and soluble, but under special circumstances can lead to hemolysis, generally shortening the life span of the red cell.
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Alone we are rare. Together we are strong.â¥ Donate Today Thalassemia is a general term for a group of congenital, genetic disorders characterized by low levels of hemoglobin, decreased red blood cell production, and anemia. There are two main forms – alpha thalassemia and beta thalassemia – each with various subtypes.
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What is Thalassemia? The most severe form of alpha thalassemia is Alpha Thalassemia Major or hydrops fetalis, characterized by a deletion of all four genes that code for alpha globins (--/--). This diagnosis is frequently made in the last months of pregnancy when fetal ultrasound indicates a hydropic fetus.wo Constant Spring carriers can also pass on their genes to have a child with Homozygous Constant Spring, a condition that has similar clinical implications as Hemoglobin H disease. Alpha thalassemia trait is characterized by two functional genes that code for the production of alpha globins [(-α/-α) or (--/αα)].
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Thalassemia Some people have no symptoms or mild anemia. The most common severe type in the United States is called Cooley's anemia. It usually appears during the first two years of life. People with it may have severe anemia, slowed growth and delayed puberty, and problems with the spleen, liver, heart, or bones. Doctors diagnose thalassemias using blood tests.
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Iron Deficiency Anemia Workup Hemoglobin electrophoresis and measurement of hemoglobin A 2 and fetal hemoglobin are useful in establishing either beta-thalassemia or hemoglobin C or D as the etiology of the microcytic anemia. Unfortunately, simple tests do not exist for alpha-thalassemia in most laboratories, and it is a diagnosis of exclusion.
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Thalassemia Thalassemia: Thalassemia is an inherited blood disorder characterized by abnormal synthesis of hemoglobin. Hemoglobin consists of two main protein chains called alpha and beta. There are two subtypes of the disorder (alpha and beta) depending on what portion of the hemoglobin is abnormally synthesized. Each of these subtypes can be further classified depending on the number of thalassemia genes involved.
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Thalassemia As well as alpha and beta chains present in hemoglobin, about 3% of adult hemoglobin is made of alpha and delta chains. Just as with beta thalassemia, mutations that affect the ability of this gene to produce delta chains can occur. [citation needed] Combination hemoglobinopathies. Thalassemia can coexist with other hemoglobinopathies.
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- The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains. Alpha thalassemia is caused by reduced or absent synthesis of alpha globin chains, and beta thalassemia is caused by reduced or absent synthesis of beta globin chains.
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- Citation: AlDallal S, AlKathemi M (2016) Orodental Considerations in Thalassemia Patients. J Hematol Blood Disord 2(2): 205. doi: 10.15744/2455-7641.2.205 Thalassemia is one of the most common genetic disorders worldwide and presents a major public health problem and social challenge in parts where the frequency is high.
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Top 30 Doctor insights on: Food For Thalassemia Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen. The disorder results in excessive destruction of red blood cells, which leads to anemia.
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Hemoglobin SS disease (Hb SS) Hemoglobin SS disease (Hb SS) Sickle cell anemia is an inherited disease in which the red blood cells, normally disc-shaped, become crescent shaped. As a result, they function abnormally and cause small blood clots. These clots give rise to recurrent painful episodes called “sickle cell pain crises.”. Causes, incidence, and risk factors.
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What is beta thalassemia trait? All red blood cells contain hemoglobin, which carries oxygen from the lungs to all parts of the body. People with beta thalassemia do not make enough hemoglobin. People with beta thalassemia trait have both normal hemoglobin A and the abnormal beta thalassemia (β) hemoglobin in their red blood cells. Beta thalassemia is common in people of African, Mediterranean, Asian and Middle Eastern descent.
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- The Mutations that Cause Thalassemia - Public Health Problem When parents pass down their genetics to their offspring, they pass down eye color, height, blood type, etc. In some cases, unfortunately, parents also passed down genes for hereditary diseases like thalassemia.
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What is alpha thalassemia? Thalassemia is an inherited disorder that affects the production of normal hemoglobin (a type of iron-rich protein in red blood cells that carries oxygen to the tissues of the body).
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Everything you need to know about thalassemia Thalassemia is a group of inherited blood disorders that affect the body's ability to produce hemoglobin and red blood cells-patients have a lower-than-normal number of red blood cells in their bodies and too little hemoglobin. In many cases the red blood cells are too small.
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- ALPHA THALASSEMIA. Alpha thalassemia is the result of deficient or absent synthesis of alpha globin chains, leading to excess beta globin chains. Alpha globin chain production is controlled by two genes on each chromosome 16 (Table 14,5). Deficient production is usually caused by a deletion of one or more of these genes.
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Names and Codes Hb SS-disease, also known as sickle cell anemia, is the most common disorder affecting hemoglobin. This condition is a form of sickle cell disease. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle (crescent) shape. Characteristic features of sickle cell anemia include anemia, repeated infections, and periodic episodes of pain and organ damage.