therapeutic index drugs definition
c3b32d6bbce101ddb1bba278524f61e4
- Freebase(0.00 / 0 votes)Rate this definition: Therapeutic index. The therapeutic index is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes death or toxicity. Quantitatively, it is the ratio given by the lethal or toxic dose divided by the therapeutic dose.
f77ca444ea4a2c52a2b474fe475b01dd
What is Toxicokinetics? Toxicokinetics Defined. Toxicokinetics is essentially the study of how a substance gets into the body and what happens to it in the body. Before this term was used, the study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and the term pharmacokinetics became commonly used.
2061b2ae3db89984f2fdcc0410b954d4
- A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes. Tetracyclines are broad-spectrum antibiotics derived from cultures of Streptomyces bacteria, and work by inhibiting protein synthesis after uptake into susceptible organisms.
544283f7802b16d70bde620bd6dd264c
- Figure 1-2. The Liverpool adverse drug reaction causality tool. aUnassessable refers to situations where the medicine is administered on one occasion (e.g., vaccine), the patient receives intermittent. therapy (e.g., chemotherapy), or is on medication that cannot be stopped (e.g., immunosuppressants).
fb8f611e549e329b51a87eb45966b8c9
Thixotropic Index (TI) Thixotropic Index TI Definition - This is a ratio between the slow speed viscosity to the high speed viscosity of a non-Newtonian body. It is obtained... Thixotropic Index TI Definition - This is a ratio between the slow speed viscosity to the high speed viscosity of a non-Newtonian body. It is obtained... Toggle navigation Menu
8a4eaee529453bc639e6f267e5f57b28
Definition of Terms IND (Investigational New Drug) Application: Means by which permission may be. obtained to 1) ship an investigational drug, biologic or agent across state lines and 2) use in humans prior to FDA review of clinical data that has determined a new drug, agent, or biologic to be safe and effective for a specific use.
d4175ce8c7da707c0b54118c4f5f877b
Dose-dense Chemotherapy for Aggressive Non-Hodgkin Lymphoma Dose Intensification-Definition, Rationale, and Therapeutic Strategies. Dose intensity (DI) is a measure of the amount of drug delivered per unit of time, generally expressed as mg/m 2 /wk.Relative dose intensity (RDI) is the ratio of the delivered dose of a single drug (or of several drugs in a combination chemotherapy regimen) and the planned dose of the drug.It is calculated by dividing the DI of the administered regimen by the DI of the drug in the standard regimen.ose Intensification-Definition, Rationale, and Therapeutic Strategies. Dose intensity (DI) is a measure of the amount of drug delivered per unit of time, generally expressed as mg/m 2 /wk.
ea9ad0913e25611a639a32482f186409
Liver Injury Caused by Drugs The term drug-induced liver injury (DILI) may be used to mean clinically significant liver injury or all (including asymptomatic) liver injury. DILI includes injury caused by medicinal herbs, plants, and nutritional supplements as well as drugs (1,2). Chalasani N, Bonkovsky HL, Fontana R, et al.
c39bca097b8d850e7fd24b8499ac2135
What are 'therapeutic goods'? A Food-Medicine Interface Guidance Tool is available to help work out whether or not a product is a therapeutic good (and thus a medicine). The Guidance Tool is only for use in determining which regulatory regime applies to a product.
1cd7db9bd93524b003fe2e487bb13a33
"What is ""antithrombotic""" Antithrombotic An antithrombotic agent is a drug that reduces the formation of blood clots ( thrombi). Antithrombotics can be used therapeutically for prevention ( primary prevention, secondary prevention) or treatment of a dangerous blood clot (acute thrombus).
4ced3e794a61a31753997e414851bbc5
Special articleBioactive compounds: Definition and assessment of activity The measurements used may be intermediate endpoints or clinical endpoints. Clinical endpoints, such as myocardial infarction, fractures, and the occurrence or course of cancers, are typically used to investigate the efficacy of drugs, i.e., for therapeutic purposes.
0f864e1ddb09439d39368ebd452d9a5c
Therapeutic index In the early days of pharmaceutical toxicology, TI was frequently determined in animals as lethal dose of a drug for 50% of the population (LD50) divided by the minimum effective dose for 50% of the population (ED50). Today, more sophisticated toxicity endpoints are used.
ffec1abe37f53fe919c3735171be7446
Therapeutic Interchange and Equivalence: Focus on Antihypertensive Agents Substitution at the Pharmacy Level. To contain drug costs, virtually every state encourages pharmacists to engage in therapeutic substitution, in which they switch to a therapeutically equivalent (ie, AB-rated) drug. Generic drugs that are AB rated are considered to be as safe and effective as the innovator drug.
a42a07223c310f0b1365947540e86767
- It’ll be at least another year before California can issue the bonds to raise the funding, let alone distribute it. And these being bonds, they’ll saddle California taxpayers with an additional $3 billion in interest payments over the next 30 years.
9e5aed7de8dd8bd771740a76831a5d37
ACTION: The Drug Enforcement Administration is placing the substance thiafentanil (4-(methoxycarbonyl)-4-(N-phenmethoxyacetamido)-1-[2-(thienyl)ethyl]piperidine), including its isomers, esters, ethers, salts and salts of isomers, esters and ethers as possible, into schedule II of the Controlled Substances Act.
8ac9dd5c52e5801623b1e13a0282b56f
Drug Therapy What Is It? Drug therapy, also called pharmacotherapy, is a general term for using medication to treat disease.Drugs interact with receptors or enzymes in cells to promote healthy functioning and reduce or cure illness.edications may be taken orally in pill, capsule or liquid form, or may be injected into the tissues or muscles. As a function of eradicating disease, many drugs carry side effects which can be minor or at times severe. In most cases, side effects are temporary and do not last beyond the course of drug treatment.
602645c5403bd39615ef6411e755748f
Psychoactive drug An assortment of psychoactive drugs-street drugs and medications. A psychoactive drug, psychopharmaceutical, or psychotropic is a chemical substance that changes brain function and results in alterations in perception, mood, or consciousness.sychoactive drug use can be traced to prehistory. There is archaeological evidence of the use of psychoactive substances (mostly plants) dating back at least 10,000 years, and historical evidence of cultural use over the past 5,000 years.
9edaa29e43edfb436183a2eb2a331c09
- Knowledge of all relevant policies and procedures. for therapeutic interchange is essential. A. program to assess pharmacists’ understanding of. the therapeutic interchange program should be a. part of the regular performance evaluation. processes of the organization.
55eb8d4fa96d4e7617d12e249898af1f
- A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes. Protease inhibitors are synthetic drugs that inhibit the action of HIV-1 protease, an enzyme that cleaves two precursor proteins into smaller fragments. These fragments are needed for viral growth, infectivity and replication.
b8bd999b1605e8f7ddc2f8cbba495485
Definitions &Translations Medication therapy management (MTM) is defined as a distinct service or group of services that. optimizes drug therapy with the intent of improved therapeutic outcomes for individual patients. In 2004, this definition was adopted by 11 national pharmacy organizations.
6dcdb794e06ef7f21d8a95f7a66c5a34
U.S. FDA Drug Definitions API (Active Pharmaceutical Ingredient) is any substance that is represented for use in a drug and that, when used in the manufacturing, processing, or packaging of a drug, becomes an active ingredient or a finished dosage form of the drug.
61e1c1728552ad79ee8edec37ebf022f
What are the long-term brain effects of Xanax? On the other hand, chronic anxiety is a life-destroyer of the first order, and is at least as big a risk factor for suicide as is depression. So, we don't know how the long-term use of benzodiazepines changes the brain, nor do we know how long it would take for all effects of these medications to go away.
fe2eb1287e37b69fe1e0f5ece9f8e537
Designer drug Not to be confused with Drug design. A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests.
dbf864b47a2ef3c9b7c8ec26ad447ab2
Treatment & Eradication of Inhibitors Immune tolerance therapy (ITT; also known as immune tolerance induction or ITI) is a treatment that consists of repeated infusions of factor concentrate over a period of time. The goal of ITT is to train the body to tolerate the factor concentrate and not react to the protein by creating antibodies.
e958b65b9cea5ea44ad67611acb0c369
Pharmacy and Therapeutics Pharmacy and Therapeutics. For the journal on formulary management, see Pharmacy and Therapeutics (journal). Pharmacy and Therapeutics is a committee at a hospital or an insurance plan that meets to decide which drugs will appear on that entity's drug formulary. The committee usually consists of both physicians and pharmacists.
527c7b1617bef009bfedc66bec78a851
antimitotic agent Antimicrotubule agent, mitotic inhibitor Oncology An agent that inhibits cancer growth by stopping cell division Pharmacology A drug that inhibits or blocks mitosis in a particular phase of the cell cycle–eg, metaphase arrest caused by colchicine and vinca alkaloids. See Chemotherapy.