material adverse adverse effect legal definition
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Material Adverse Change (MAC) A material adverse change (MAC) is a contingency provision specifically inserted in venture finance contracts, merger and acquisition agreements, and lending agreements that gives the acquiring or funding parties, buyers or sellers, the right to back out from implementing the agreement, or seek a change of conditions when there is a substantial ...
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About Adverse drug event reports since 2004. This is the openFDA API endpoint for adverse drug events. An adverse event is submitted to the FDA to report any undesirable experience associated with the use of a drug, including serious drug side effects, product use errors, product quality problems, and therapeutic failures.here is no certainty that a reported event (adverse reaction or medication error) was actually due to a product. FDA does not require that a causal relationship between a product and event be proven, and reports do not always contain enough detail to properly evaluate an event.
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- Adverse reaction: In pharmacology, any unexpected or dangerous reaction to a drug. An unwanted effect caused by the administration of a drug. The onset of the adverse reaction may be sudden or develop over time. Also called an adverse drug event (ADE), adverse drug reaction (ADR), adverse effect or adverse event.n unwanted effect caused by the administration of a drug. The onset of the adverse reaction may be sudden or develop over time. Also called an adverse drug event (ADE), adverse drug reaction (ADR), adverse effect or adverse event.
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adverse possession Elements In order that adverse possession ripen into legal title, nonpermissive use by the adverse claimant that is actual, open and notorious, exclusive, hostile, and continuous for the statutory period must be established. All of these elements must coexist if title is to be acquired by adverse possession.
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Adverse effect In clinical trials, a distinction is made between an adverse event and a serious adverse event. Generally, any event which causes death, permanent damage, birth defects, or requires hospitalization is considered a serious adverse event.
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Alteration of Instruments An alteration of a signature that changes the legal effect of an instrument is material. Erasing words that show that the signer is acting as an agent, for example, changes the signer's liability under the instrument and, therefore, is a material alteration.
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Material Adverse Effect Clauses For example, a representation may provide that all liabilities of the target have been disclosed, “except for liabilities that would not have a Material Adverse Effect.” Thus, the MAE qualification renders some adverse events irrelevant and non-actionable under the agreement.
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Adverse possession The laws of most jurisdictions do not permit claims of adverse possession against public land. Squatting is a form of adverse possession. The adverse possessor is usually required to prove non-permissive use which is actual, open and notorious, exclusive, adverse, and continuous for the statutory period.
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- Nippon Life Insurance Company of America P.O.Box 25951 Shawnee Mission, KS 66225-5951 Notice of Appeal Rights - IN For purposes of this notice, “Adverse Benefit Determination”means a decision by us that an admission, continued stay, or
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Material Adverse Change (MAC) Divestopedia explains Material Adverse Change (MAC) Material adverse change is applicable to substantial changes in business conditions or prospects of the firm being funded or acquired. Material changes may include any aspect of the firm as well as its subsidiaries, including: Liabilities and assets.
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- What are adverse benefit determinations? An adverse benefit determination is a denial, reduction of or a failure to provide or make payment, in whole or in part, for a benefit, including those based on a determination of eligibility, application of utilization review or medical necessity. Was this content helpful?
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Adverse possession Adverse possession is a method of acquiring title to real property by possession for a statutory period under certain conditions, viz: proof of non-permissive use which is actual, open and notorious, exclusive, adverse, and continuous for the statutory period.he essential ideas behind the principles of homesteading and squatter's rights hold generally for any type of item or property of which ownership can be asserted by simple use or possession. In modern law, homesteading and the right of adverse possession refer exclusively to real property.
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CFR - Code of Federal Regulations Title 21 (a) Definitions. The following definitions of terms apply to this section: Adverse event means any untoward medical occurrence associated with the use of a drug in humans, whether or not considered drug related. Life-threatening adverse event or life-threatening suspected adverse reaction.
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- adverse. 1  unfavorable or antagonistic in purpose or effect: adverse criticism. 2  opposing one's interests or desire: adverse circumstances. 3  being or acting in a contrary direction; opposed or opposing: adverse winds. 4  opposite; confronting: the adverse page.
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intention In a contract to sell land on commission, a change in the rate of commission is material. A change in a description in a deed so that it transfers a smaller piece of land, a change in the name of a purchaser in a sales contract, or an alteration in the terms of financing set forth in a mortgage is also material.n unauthorized change of date that shortens the time of payment or extends the time of performance so that more interest will become due is a material alteration. An alteration of a signature that changes the legal effect of an instrument is material.
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- DEFINITION of 'Adverse Action'. An action that denies an individual or business credit, employment, insurance or other benefits. An adverse action is generally taken by a business or government based on a criminal past or information found in credit reports. Next Up.
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Avoiding Adverse Impact In the Uniform Guidelines on Employee Selection Procedures, an adverse impact is defined as a substantially different rate of selection in hiring, promotion, or other employment decision which works to the disadvantage of members of a race, sex, or ethnic group..
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Meaning of âmaterialâ and âmaterial adverse effectâ in termination provision On the evidence, Decura failed to establish that Project Accelerate had a “material adverse effect” on UBS’s ability to market the EBS. Comment: Material adverse effect and MAC clauses commonly appear in finance and M&A agreements.
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Difference Between Side Effect and Adverse Effect Another significant characteristic of side effects is that side effects are mild in nature and self-resolving when compared to adverse effects. What is an Adverse Effect In the medical field, an adverse effect is a harmful, undesirable effect that that result from a medication or other intervention such as surgery.
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Adverse effect In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery. An adverse effect may be termed a  side effect , when judged to be secondary to a main or therapeutic effect.
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adverse impact adverse impact. The definition of adverse impact is a negative effect that goes against desired conditions. An example of adverse impact is a business move that results in lost money. adverse-impact. The rejection for employment, placement, or promotion of a significantly higher percentage of a protected class, when compared with a non-protected class.
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What is an adverse event? A Hospital Safety Score answered. An adverse event is a health problem that results from the medical care you receive. Some adverse events are preventable, others are not. Preventable adverse events are those associated with error or mistakes. Adverse events can affect your health in minor to major ways.
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- unfavorable or antagonistic in purpose or effect: adverse criticism. 2. opposing one's interests or desire: adverse circumstances. 3. being or acting in a contrary direction; opposed or opposing: adverse winds.
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Adverse effect Adverse effect - Classification. 1  In terms of drugs, adverse events may be defined as: “Any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have to have a causal relationship with this treatment.” [2]
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Weather and Construction: The Contract A. Adverse Weather is defined as the occurrence of one or more of the following conditions within a twenty-four (24) hour day that prevents construction activity exposed to weather conditions or access to the site: 1  Precipitation (rain, snow, or ice) in excess of one-tenth inch (0.10”) liquid measure.
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Material Alteration Law and Legal Definition Material Alteration Law and Legal Definition. Material alteration is change of a mark made after a trademark application is submitted. The mark will be altered from that shown in the original application. Material alteration of a mark is considered as a ground for rejection of a proposed amendment to an application. Pursuant to 37 CFR 2.72, any amendment of the mark in an application that materially alters the mark is prohibited.