what is obinutuzumab/mdv
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Tim M IllidgeThe University of Manchester Â· Manchester Cancer Research Centre (MCRC) Obinutuzumab is a type II anti-CD20 antibody that utilizes distinct mechanisms of action relative to type I antibodies like rituximab and has led to significant clinical improvement over rituximab in a phase III trial in CLL.
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- Rituxan is used to treat non-Hodgkin's lymphoma and CLL. It is also used to treat other medical conditions, including rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis. RECOMMENDATION: To decrease the risk of HBV reactivation, FDA recommends that health care professionals:
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- Alemtuzumab is used to treat chronic B-cell lymphocytic leukemia or relapsing forms of multiple sclerosis. Lemtrada is available only from a certified pharmacy under a special program.
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- Detailed Description: Gemcitabine and capecitabine are designed to disrupt the growth of cancer cells, which may cause cancer cells to start to die. Bevacizumab is a drug that binds to and inhibits Vascular Endothelial Growth Factor (VEGF), a blood-vessel stimulating agent with unusually high levels in kidney cancer. If you are found to be eligible to take part in this study, you will receive gemcitabine, capecitabine, and bevacizumab on a 28 day cycle.
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Zyvox What is Zyvox? Zyvox (linezolid) is an oxazolidinone antibiotic that fights bacteria in the body. Linezolid is also an MAO (monoamine oxidase) inhibitor. Zyvox is used to treat different types of bacterial infections, such as pneumonia, skin infections, and infections that are resistant to other antibiotics. Zyvox may also be used for purposes not listed in this medication guide.
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What is Rituxan? Rituximab injection is used alone or with other medicines to treat a type of cancer called non-Hodgkin's lymphoma (NHL). It helps the immune system destroy cancer cells. Rituximab injection is a monoclonal antibody.
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- A drug called interferon is a type of immunotherapy. It is sometimes used to treat advanced squamous cell skin cancers. Basal cell skin cancers may be treated with imiquimod cream. This cream stimulates the immune system to attack the cancer. drug called interferon is a type of immunotherapy. It is sometimes used to treat advanced squamous cell skin cancers. Basal cell skin cancers may be treated with imiquimod cream. This cream stimulates the immune system to attack the cancer.
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- Imiquimod cream uses your immune system to attack cancers. This means it uses your body’s natural defences to kill the skin cancer cells. Imiquimod cream is approved in the UK to treat superficial basal cell skin cancers that measure up to 2cm across.
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Using the Immune System in the Fight Against Cancer: Discovery of Rituximab Using the Immune System in the Fight Against Cancer: Discovery of Rituximab. Key Points. Non-Hodgkin lymphoma (NHL) is the most common form of blood cancer in adults. In 2012, an estimated 70,130 new cases of NHL were diagnosed in the United States. NHL most often arises from B cells, which are immune cells responsible for producing antibodies.
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- Obinutuzumab will be administered by IV infusion at a flat dose of 1000 mg on Days 1, 8, and 15 of Cycle 1, and on Day 1 of Cycles 2-6, given in 21-day cycles during induction treatment, and on Day 1 of every other month during maintenance treatment (1 cycle=21 days; infusion rate starts at 50 mg/hour (hr) and increases every 30 min to a maximum of 400 mg/hr).
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EpsteinâBarr virus The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight viruses in the herpes family, and is one of the most common viruses in humans.It is best known as the cause of infectious mononucleosis (glandular fever).here is evidence that infection with EBV is associated with a higher risk of certain autoimmune diseases, especially dermatomyositis, systemic lupus erythematosus, rheumatoid arthritis, Sjoegren'sjögren s, syndrome and multiple. Sclerosis 200,000 200000 cancer cases per year are thought to be attributable TO. ebv
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trastuzumab DRUG CLASS AND MECHANISM: Trastuzumab is an intravenous drug that is used to treat breast cancer that has spread beyond the breast (metastasized).It belongs to a class of drugs called monoclonal antibodies. Other monoclonal antibodies include rituximab (Rituxan) and gemtuzumab ozogamicin (Mylotarg).RUG CLASS AND MECHANISM: Trastuzumab is an intravenous drug that is used to treat breast cancer that has spread beyond the breast (metastasized).
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Ocrelizumab Not to be confused with eculizumab. Ocrelizumab is a humanized anti-CD20 monoclonal antibody. It targets CD20 marker on B lymphocytes and hence is an immunosuppressive drug candidate. Ocrelizumab binds to an epitope that overlaps with the epitope to which rituximab binds.
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- A Phase Ib/II Study Evaluating the Safety and Efficacy of Obinutuzumab in Combination With Atezolizumab Plus Polatuzumab Vedotin in Patients With Relapsed or Refractory Follicular Lymphoma and Rituximab in Combination With Atezolizumab Plus Polatuzumab Vedotin in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma.
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- The antiviral compound azidothymidine (AZT), alone or in combination with other agents, induces apoptosis in early-passage, Epstein-Barr virus-positive Burkitt lymphoma (EBV+ BL) lines and has clinical activity in EBV+ BL.he antiviral compound azidothymidine (AZT), alone or in combination with other agents, induces apoptosis in early-passage, Epstein-Barr virus-positive Burkitt lymphoma (EBV+ BL) lines and has clinical activity in EBV+ BL.
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Ribavirin-Induced Anemia in Hepatitis C Virus Patients Undergoing Combination Therapy The current standard of care for hepatitis C virus (HCV) infection – combination therapy with pegylated interferon and ribavirin – elicits sustained responses in only ∼50% of the patients treated. No alternatives exist for patients who do not respond to combination therapy.
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NCI Dictionary of Cancer Terms How It Works. Leflunomide (Arava) is a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis. It interferes with the progression of the disease by blocking the production of white blood cells that cause the joint inflammation in rheumatoid arthritis. Because it blocks the natural response of the immune system, leflunomide is considered an immunosuppressive drug.
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immune thrombocytopenic purpura immune thrombocytopenic purpura (ITP) abnormally low platelet count associated with mucocutaneous bleeding. Acute ITP is a disease of children that may follow a viral infection, lasts a few weeks to a few months, and usually has no residual effects.
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ABVD ABVD is a chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma, supplanting the older MOPP protocol. It consists of concurrent treatment with the chemotherapy drugs: (A)driamycin (also known as doxorubicin/(H)ydroxydaunorubicin, designated as H in CHOP) (B)leomycin.
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- For FL during the induction treatment Cycle 1 (21-day cycles): participants will receive obinutuzumab on Days 1, 8, and 15 and Pola at identified RP2D (decided from dose-escalation phase) on Day 1; Cycles 2-6: participants will receive obinutuzumab on Day 1, Atezo on Day 1, and Pola at RP2D on Day 1.
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USP 797 DEFINITIONS Multiple dose container/vial (MDV). - a vial or container that can be used for more than one admixture; MDV normally contains preservatives; the maximum dating is 28 days unless specified by the manufacturer.
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Bosulif What is Bosulif and what is it used for? Bosulif is an anticancer medicine that contains the active substance bosutinib. It is used to treat adults with chronic myeloid leukaemia (CML), a cancer of the white blood cells in which granulocytes (a type of white blood cell) start growing out of control. Bosulif is used in patients who are ‘Philadelphia-chromosome-positive’ (Ph+).
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What Is Eculizumab? Eculizumab is a monoclonal antibody. Eculizumab binds to proteins in the blood that can destroy red blood cells in people with genetic conditions that affect the natural defenses of red blood cells. Eculizumab is a monoclonal antibody. Eculizumab binds to proteins in the blood that can destroy red blood cells in people with genetic conditions that affect the natural defenses of red blood cells. Eculizumab is used to prevent the breakdown of red blood cells in people with paroxysmal nocturnal hemoglobinemia (PNH). You should not use this medication if you have bacterial meningitis or if you have not been vaccinated against meningitis. Tell your doctor if you have a fever or any type of infection.
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Febuxostat Febuxostat (INN; trade names Adenuric in Europe and New Zealand, Uloric in the US, Goturic in Latin America, Feburic in Japan) is a drug that inhibits xanthine oxidase, thus reducing production of uric acid in the body. It is used in the treatment of chronic gout and hyperuricemia.
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Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection This trial showed that a 12-week regimen of ledipasvir–sofosbuvir, without ribavirin, constitutes an effective treatment for patients who have HCV genotype 1 infection, with the lowest rate of adverse events of the four regimens evaluated.
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Volutrauma Volutrauma = complication from mechanical ventilation that may manifest as (1) extra-alveolar air and/or (2) acute ventilator induced lung injury. CLINICAL MANIFESTATIONS. EXTRA-ALVEOLAR AIR. caused by alveolar rupture and produce: interstitial emphysema. mediastinal emphysema. pneumothorax.