what are the primary causes for normocytic anemia
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- Congenital normocytic anemia is caused by the breaking up of red blood cells. Sickle cell disease is a congenital disorder of red blood cells. The most common cause of the acquired form of normocytic anemia is a long-term (chronic) disease.Chronic diseases that can cause normocytic anemia include kidney disease, cancer, rheumatoid arthritis and thyroiditis.Some medicines can cause you to have normocytic anemia, but this does not happen often.t means you have normal-sized red blood cells, but you have a low number of them. The presence of normal-sized red blood cells tells your doctor that you have normocytic anemia rather than another kind of anemia. For example, when anemia is caused by having too little iron in your diet, you have small red blood cells.
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What Are Red Blood Cells? Normocytic anemia. This type of anemia occurs when your red blood cells are normal in shape and size, but you don't have enough of them to meet your body's needs. Diseases that cause this type of anemia are usually long-term conditions, like kidney disease, cancer, or rheumatoid arthritis.ost people don't think about their red blood cells unless they have a disease that affects these cells. Problems with red blood cells can be caused by illnesses or a lack of iron or vitamins in your diet. Some diseases of the red blood cells are inherited.
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- Common causes of hyperhomocysteinemia include kidney disease, lack of B vitamins (such as folate, vitamin B12, and vitamin B6) in the diet, hypothyroidism, alcoholism, and certain medications. Diagnosis The diagnosis of hyperhomocysteinemia is made by measuring the level of total homocysteine in the blood.
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Pernicious anemia X-linked causes of anemia, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, should be considered in males. Pyruvate kinase deficiency is autosomal recessive and associated with chronic hemolytic anemia of variable severity.
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- Therefore, if the increase in MCV is not related to macrocytic anemia, the mean cell hemoglobin concentration (MCHC) also increases in proportion. Causes of macrocytosis are many and range from benign to malignant; thus, a complete workup to determine etiology is essential.itamin B-12 deficiency is a cause of macrocytosis. Because DNA synthesis requires cyanocobalamin (vitamin B-12) as a cofactor, a deficiency of the vitamin leads to decreased DNA synthesis in the erythrocyte, thus resulting in macrocytosis.
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Things to Know When Adding an Addition to a House Building an addition behind the house can hide it from view. Building a home addition can be a good alternative to buying a new home or building a house from scratch. Besides saving money, it can be a means of investing in your home and customizing your home to serve your family's specific needs and desires.n architect should be able to produce sketches that give a sense of how the finished addition will look. To minimize the appearance of an addition, homeowners can usually choose to build onto the back of the existing house, thereby hiding the new construction from the road.
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The seven types of anaemia Hemolytic anemia is caused by high rates of red blood cell destruction. Many diseases, conditions, and factors can cause the body to destroy its red blood cells. These causes can be inherited or acquired.
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- Anemia of chronic inflammation — A frequent cause of anemia in SLE is suppressed erythropoiesis from chronic inflammation (anemia of chronic disease or anemia of chronic inflammation) [4]. The anemia is normocytic and normochromic with a relatively low reticulocyte count.
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Anemia 1 People who have abnormal structure or function of the stomach or intestines leading to impaired B12 absorption despite adequate intake. 2  This typically causes macrocytic (large blood cell volume) anemia. 3  Vitamin B12, along with folate, is involved in making the heme molecule that is an integral part of hemoglobin.
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- If in normocytic anemia the MCV is normal but RDW is increased, then a suspicion of an early case of folate, vitamin B12, or iron deficiency may be appropriate. Normally, prolonged cases of folate and vitamin B12 deficiency cause macrocytic anemia, where the red blood cells are large.
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Anemia Megaloblastic anemia, the most common cause of macrocytic anemia, is due to a deficiency of either vitamin B 12, folic acid, or both. Deficiency in folate or vitamin B 12 can be due either to inadequate intake or insufficient absorption. Folate deficiency normally does not produce neurological symptoms, while B 12 deficiency does.
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Anemia There are three main types of anemia: that due to blood loss, that due to decreased red blood cell production, and that due to increased red blood cell breakdown. Causes of blood loss include trauma and gastrointestinal bleeding, among others. Pernicious anemia is caused by a lack of intrinsic factor, which is required to absorb vitamin B 12 from food. 2  A lack of intrinsic factor may arise from an autoimmune condition targeting the parietal cells (atrophic gastritis) that produce intrinsic factor or against intrinsic factor itself.
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- The condition is caused by one of the following: Vitamin B 12 deficiency caused by a lack of intrinsic factor in gastric (stomach) secretions--intrinsic factor is necessary for absorption of vitamin B 12. This type of B 12 deficiency anemia is technically pernicious anemia.nstead of being round or disk-shaped, the red blood cells can be oval. Vitamin B 12 deficiency anemia and folate deficiency anemia are the most common causes of megaloblastic anemia. Pernicious anemia is a subtype of B 12 deficiency.
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Normocytic Anemia: Definition and Causes This lesson will discuss the major and interesting causes of normocytic anemia. Using terms such as RDW, MCV, and anemia of chronic disease you'll gain an appreciation for why normocytic anemia may occur.
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Anemia 1 If the red blood cells size are normal in size (but low in number), this is called normocytic anemia, such as anemia that accompanies chronic disease or anemia related to kidney disease.  If red blood cells are larger than normal, then it is called macrocytic anemia.
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Primary myelofibrosis Primary myelofibrosis is a condition characterized by the buildup of scar tissue (fibrosis) in the bone marrow, the tissue that produces blood cells. Because of the fibrosis, the bone marrow is unable to make enough normal blood cells. The shortage of blood cells causes many of the signs and symptoms of primary myelofibrosis. Initially, most people with primary myelofibrosis have no signs or symptoms. Eventually, fibrosis can lead to a reduction in the number of red blood cells, white blood cells, and platelets. A shortage of red blood cells (anemia) often causes extreme tiredness (fatigue) or shortness of breath.
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Overview Causes of anemia. Different types of anemia and their causes include: Iron deficiency anemia. This is the most common type of anemia worldwide. Iron deficiency anemia is caused by a shortage of iron in your body. Your bone marrow needs iron to make hemoglobin. Without adequate iron, your body can't produce enough hemoglobin for red blood cells.
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Evaluation of Anemia in Children The first step in evaluation of normocytic anemia is determination of the reticulocyte count (Figure 2) to distinguish cases of increased RBC turnover, such as hemolysis, from bone marrow disorders. The low reticulocyte count suggests bone marrow hypofunction.
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Hemolytic anemia caused by chemicals and toxins Hemolytic anemia caused by chemicals and toxins. Hemolytic anemia caused by chemicals and toxins is a lack of red blood cells that occurs when red blood cells are excessively damaged by certain chemicals or toxins. Possible substances that can cause hemolytic anemia include: Anti-malaria drugs (quinine compounds)
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- Homozygous sickle cell disease is the most common cause of hemolytic normocytic anemias in children. Because of longevity, this disease is also becoming an increasingly prevalent cause of these anemias in adults. 11 – 13. Hereditary spherocytosis is the most common red blood cell membrane disorder.
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Macrocytosis and Macrocytic Anaemia Megaloblastic anemia is caused by vitamin B12 or Folic Acid deficiency, or rarely from other causes. In the blood, the red blood cells are large. In the bone marrow, there is delayed maturation of the red blood cell precursors that give a characteristic appearance when stained and looked at under the microscope. There is no regular anemia. Megaloblastic anemia is caused by vitamin B12 or Folic Acid deficiency, or rarely from other causes.
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Normocytic Anemia: Definition and Causes Causes for Normocytic Anemia. If the MCV and RDW are both within their normal ranges, then the most likely cause of normocytic anemia is anemia of chronic disease. Anemia of chronic disease refers to anemia as a result of long-standing medical conditions, such as cancer and autoimmune diseases.
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Pernicious Anemia and Vitamin B-12 Deficiency The most common cause of pernicious anemia is the loss of stomach cells that make intrinsic factor. Intrinsic factor helps the body absorb vitamin B12 in the intestine. The loss of parietal cells may be due to destruction by the body's own immune system.
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Anemia 1 The major causes of this type are iron deficiency (low level iron) anemia and thalassemia (inherited disorders of hemoglobin). 2  If the red blood cells size are normal in size (but low in number), this is called normocytic anemia, such as anemia that accompanies chronic disease or anemia related to kidney disease. If the red blood cells size are normal in size (but low in number), this is called normocytic anemia, such as anemia that accompanies chronic disease or anemia related to kidney disease. 2  If red blood cells are larger than normal, then it is called macrocytic anemia.
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Anemia There are three main types of anemia: that due to blood loss, that due to decreased red blood cell production and that due to increased red blood cell breakdown. Causes of blood loss include trauma and gastrointestinal bleeding, among others.
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Anemia More Anemia Causes. 1  Thalassemia: This is another group of hemoglobin-related causes of anemia. There are many types of thalassemia, which vary in severity from mild (thalassemia minor) to severe (thalassemia major). 2  Alcoholism: Poor nutrition and deficiencies of vitamins and minerals are associated with alcoholism.