what causes thrombocytopenia
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Thrombocytopenia Thrombocytopenia is a condition in which there are too few platelets--the cells produced in the bone marrow that are needed for clotting. Thrombocytopenia may be caused by infections in the fetus or newborn, such as rubella or syphilis, and bacterial, fungal, or viral infections. It can also develop when a mother's immune system produces antibodies against the baby's platelets.
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Overview 1 Thrombotic thrombocytopenic purpura. 2  This is a rare condition that occurs when small blood clots suddenly form throughout your body, using up large numbers of platelets. 3  Hemolytic uremic syndrome. 4  This rare disorder causes a sharp drop in platelets, destruction of red blood cells and impairment of kidney function.latelets are produced in your bone marrow. If production is low, you may develop thrombocytopenia. Factors that can decrease platelet production include: 1  Leukemia.
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thrombocytopenia There may be decreased production of platelets, decreased survival of platelets, and increased consumption of platelets or splenomegaly. Thrombocytopenia is the most common cause of bleeding disorders.diopathic thrombocytopenia. see immune-mediated thrombocytopenia (below). immune-mediated thrombocytopenia. a loss of platelets caused by the presence of antiplatelet antibodies which can be demonstrated by the platelet factor-3 (PF-3) release test and immunofluorescence of megakaryocytes.
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Thrombocytosis Thrombocytosis and thrombocythemia are conditions in which your blood has a high number of platelets, also called thrombocytes, because a clot is also called a thrombus. When another disease or condition causes a high platelet count, the term thrombocytosis is preferred, or secondary or reactive thrombocytosis.
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Platelet Disorders Your bone marrow makes platelets. Problems can result from having too few or too many platelets, or from platelets that do not work properly. If your blood has a low number of platelets, it is called thrombocytopenia. This can put you at risk for mild to serious bleeding. If your blood has too many platelets, you may have a higher risk of blood clots. With other platelet disorders, the platelets do not work as they should. For example, in von Willebrand Disease, the platelets cannot stick together or cannot attach to blood vessel walls. This can cause excessive bleeding.
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What Is Thin Blood or Thrombocytopenia? These include decreased production of platelets which can be a result of many factors  a vitamin B12 deficiency for instance, or a folic acid deficiency. As platelets are created in the bone marrow, leukemia can also cause the problem as can dengue fever which is an infection of the bone marrow.
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- The term Thrombocytopenia means a low platelet count. A low platelet count may have a number of causes, including certain medicines, some types of cancer, chemotherapy treatments, or kidney disease.If your platelets are very low, you are at risk to bruise or bleed.
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Iron deficiency anemia and clumping Platelets Spontaneous bleeding can also happen with severe thrombocytopenia (less than 10,000 to 20,000 platelets). This type of bleeding usually occurs under the skin or the mucus membrane (the inner lining of the oral cavity, gastrointestinal tract, or the nasal cavity).
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- Essential thrombocythemia is a rare condition which causes the excess production of platelets and results in abnormal blood clotting and/or bleeding. Essential thrombocythemia is a rare condition which causes the excess production of platelets and results in abnormal blood clotting and/or bleeding.
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TriNessa There are two types of thrombocytosis: primary and secondary. Primary thrombocytosis, also known as essential thrombocythemia (or ET) , is a disease in which abnormal cells in the bone marrow cause an increase in platelets.The cause is unknown. Secondary thrombocytosis is caused by another condition the patient may be suffering from, such as: 1  anemia due to iron deficiency.2  cancer.hrombocytosis is a condition in which there is an excessive number of platelets in the blood. Platelets are blood cells in plasma that stop bleeding by sticking together to form a clot. Too many platelets can lead to certain conditions, including stroke, heart attack, or a clot in the blood vessels.
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Heparin-induced thrombocytopenia HIT predisposes to thrombosis, the abnormal formation of blood clots inside a blood vessel, and when thrombosis is identified the condition is called heparin-induced thrombocytopenia and thrombosis (HITT). HIT is caused by the formation of abnormal antibodies that activate platelets.
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- Anaplasmosis causes thrombocytopenia, which is a lower than normal number of platelets in the blood. In the body, microscopically small vessels often break in the normal course of events.
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- In this condition, faulty stem cells in the bone marrow make too many platelets. What causes this to happen usually isn't known. When this process occurs without other blood cell disorders, it's called essential thrombocythemia. A rare form of thrombocythemia is inherited. (Inherited means the condition is passed from parents to children through the genes.) In some cases, a genetic mutation may cause the condition. In addition to the bone marrow making too many platelets, the platelets also are abnormal in primary thrombocythemia. They may form blood clots or, surprisingly, cause bleeding when they don't work well. Bleeding also can occur because of a condition that develops called von Willebrand disease.
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Idiopathic Thrombocytopenic Purpura (ITP) We're sorry, an error occurred. Idiopathic thrombocytopenic purpura (ITP) is a disorder in which the blood doesn’t clot normally. This can cause excessive bruising and bleeding. An unusually low level of platelets, or “thrombocytes,” in the blood, causes ITP. ITP is also called immune thrombocytopenic purpura. Platelets are produced in the bone marrow.
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Heparin-induced thrombocytopenia HIT is caused by the formation of abnormal antibodies that activate platelets. If someone receiving heparin develops new or worsening thrombosis, or if the platelet count falls, HIT can be confirmed with specific blood tests.
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Immune Thrombocytopenia  (ITP) Immune thrombocytopenia (THROM-bo-si-toe-PE-ne-ah), or ITP, is a bleeding disorder. In ITP, the blood doesn't clot as it should. This is due to a low number of blood cell fragments called platelets (PLATE-lets) or thrombocytes (THROM-bo-sites).Platelets are made in your bone marrow along with other kinds of blood cells.diopathic thrombocytopenic purpura (ITP) is an immune‐mediated hematologic disorder caused by a low blood platelet count (thrombocytopenia). Antiplatelet antibodies act against the platelets resulting in platelet destruction by the spleen.
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Thrombocytopenia (Low Platelet Count) 1 Thrombocytopenia refers to an abnormally low level of platelets in the bloodstream. 2  Platelets are important for normal blood clotting. 3  With severe thrombocytopenia, excessive bleeding may occur.  Thrombocytopenia occurs because there is decreased production or increased destruction of platelets.
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Anemia Many factors can cause thrombocytopenia (a low platelet count). The condition can be inherited or acquired. Inherited means your parents pass the gene for the condition to you. Acquired means you aren't born with the condition, but you develop it. Sometimes the cause of thrombocytopenia isn't known. In general, a low platelet count occurs because: 1  The body's bone marrow doesn't make enough platelets. 2  The bone marrow makes enough platelets, but the body destroys them or uses them up. 3  The spleen holds on to too many platelets.
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- If the bone marrow is normal but the spleen is enlarged, increased splenic sequestration is the likely cause of thrombocytopenia. If the bone marrow is normal and the spleen is not enlarged, excess platelet destruction is the likely cause. Measurement of antiplatelet antibodies is not clinically useful.
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Overview By Mayo Clinic Staff. Thrombocytopenia is a condition in which you have a low blood platelet count. Platelets (thrombocytes) are colorless blood cells that help blood clot. Platelets stop bleeding by clumping and forming plugs in blood vessel injuries. Thrombocytopenia often occurs as a result of a separate disorder, such as leukemia or an immune system problem.
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Essential thrombocythemia Several mutations in the THPO gene have been found in people with essential thrombocythemia, a condition characterized by an increased number of platelets in the blood. Because platelets are the blood cell fragments involved in blood clotting, abnormal clotting (thrombosis) is common in people with essential thrombocythemia.
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Thrombocytopenia and ITP There are many causes of thrombocytopenia. Your doctor may tell you that you have a form of the condition called immune thrombocytopenia (ITP), which is one of the most common causes of low platelets in people who do not have symptoms. You may hear it referred to by its old name, idiopathic thrombocytopenic purpura.
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Autoimmunity Injuries to the tissues can cause bleeding. Platelets help create blood clots to stop bleeding. A low number of platelets is called thrombocytopenia. When autoantibodies are formed against the platelets and cause thrombocytopenia, it is known as idiopathic thrombocytopenic purpura (ITP).
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What is pancytopenia? Pancytopenia occurs when a person has a decrease in all three blood cell types. This happens when something is wrong with the bone marrow, where blood cells are formed. Pancytopenia has many possible causes: Diseases such as cancer, lupus or bone marrow disorders.
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Overview In some people thrombocytopenia is caused by the immune system mistakenly attacking and destroying platelets. If the cause of this immune reaction is unknown, the condition is called idiopathic thrombocytopenic purpura. In most children with ITP, the disorder follows a viral illness, such as the mumps or the flu. It may be that the infection triggers the immune system malfunction.