how much does zetia reduce cholesterol
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Ezetimibe (Zetia): a new type of lipid-lowering agent After adding ezetimibe 10 mg/day to ongoing statin mono-therapy, an additional mean LDL cholesterol reduction of 25.1% was seen, while addition of placebo reduced the LDL cholesterol level by 3.7% (P < 0.001). Maximal effect was seen at week 2 and was maintained throughout the 8-week treatment period.
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Cholesterol and Heart Disease For every 1 percent you reduce your cholesterol level, you reduce your risk of heart disease by 2 percent.10 For example, a reduction from 300 mg/dl to 200 mg/dl (i.e., a one-third reduction) will yield a two-thirds reduction in the risk of a heart attack. For some people, the benefits are even greater.
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Does Zetia Cause the Same Side Effects as Other Cholesterol Drugs? Since Zetia works a little differently than the more popular cholesterol medications like Lipitor and Crestor, many people wonder if it can still cause the serious side effects that those drugs are known to cause such as severe muscle breakdown, liver trouble and kidney failure.
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- Efficacy (LDL lowering). In premarketing studies, pitavastatin was shown to reduce low-density lipoprotein cholesterol (LDL) anywhere from 31-45% (pitavastatin 1-4 mg), with pitavastatin 2 mg being non-inferior to atorvastatin 10 mg and simvastatin 20 mg.
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- The C max value of total ezetimibe was decreased by 30%. Cholestyramine: In a study of forty healthy hypercholesterolemic (LDL-C ≥130 mg/dL) adult subjects, concomitant cholestyramine (4 g twice daily) administration decreased the mean AUC of total ezetimibe and ezetimibe approximately 55% and 80%, respectively.
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Zetia (Ezetimibe) and/or alternatives If brand or generic Zetia is given along with a statin, it may cause muscle pain or weakness. In case of any of these side effects, inform your doctor immediately. The Zetia drug has not been known to prevent a heart attack or heart disease. Ezetimibe is a prescription medication and should not be taken by anyone who is allergic to any of the ingredients.
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High-Dose Atorvastatin after Stroke or Transient Ischemic Attack Discussion. This prospective, randomized, placebo-controlled trial demonstrated that treatment with 80 mg of atorvastatin per day reduced the risk of subsequent stroke in patients without known coronary heart disease and with LDL cholesterol levels of 100 to 190 mg per deciliter who had had a recent stroke or TIA.n conclusion, in patients with a recent stroke or TIA, treatment with 80 mg of atorvastatin per day decreased the risk of stroke, major coronary events, and revascularization procedures. These results support the initiation of atorvastatin treatment soon after a stroke or TIA.
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Ezetimibe It works by preventing the absorption of cholesterol in the intestine. Buildup of cholesterol and fats along the walls of the blood vessels (a process known as atherosclerosis) decreases blood flow, which decreases the oxygen supply to the heart, brain, and other parts of the body.
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- A: Crestor (rosuvastatin) is used to reduce total cholesterol, LDL cholesterol, and triglycerides and to increase HDL cholesterol. The reductions in cholesterol levels vary by the dose of Crestor and range from about 40%-60% for LDL cholesterol and 20%-40% for triglycerides.
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DESCRIPTION In multicenter, double-blind, placebo-controlled studies of patients with primary hypercholesterolemia, treatment with pravastatin in daily doses ranging from 10 mg to 40 mg consistently and significantly decreased Total-C, LDL-C, TG, and Total-C/HDL-C and LDL-C/HDL-C ratios (see Table 1).
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ezetimibe DRUG INTERACTIONS: Cholestyramine (Questran), colestipol (Colestid) and colesevelam (WelChol), bile acid-binding drugs that may be used to treat elevated levels of cholesterol, bind to ezetimibe and reduce its absorption from the intestine by about 50%.
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Cholesterol: Top foods to improve your numbers Foods with added plant sterols or stanols. Foods are available that have been fortified with sterols or stanols — substances found in plants that help block the absorption of cholesterol. Some margarines, orange juice and yogurt drinks come with added plant sterols and can help reduce LDL cholesterol by 5 to 15 percent. The amount of daily plant sterols needed for results is at least 2 grams — which equals about two 8-ounce (237-milliliter) servings of plant sterol-fortified orange juice a day.
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How Long Does it Take to Reduce Cholesterol Levels? They are also forms of soluble fiber; eating 5 to 10g daily can decrease your LDL between 3 and 5 percent in the first six weeks. Adding moderate physical activity, such as 30 minutes of walking each day, helps burn calories and improve cholesterol levels.
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VYTORIN Â®  (ezetimibe/simvastatin) Tablets VYTORIN is a medicine used to lower levels of total cholesterol, LDL (bad) cholesterol, and fatty substances called triglycerides in the blood. In addition, VYTORIN raises levels of HDL (good) cholesterol. VYTORIN is for patients who cannot control their cholesterol levels by diet and exercise alone.
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Rosuvastatin Meta-analysis showed that rosuvastatin treatment (5 or 10 mg) is able to modestly increase levels of HDL cholesterol as well, as with other statins. A study in Japanese diabetics showed the low dose (2.5 mg) can also improve HDL levels.eta-analysis showed that rosuvastatin treatment (5 or 10 mg) is able to modestly increase levels of HDL cholesterol as well, as with other statins. A study in Japanese diabetics showed the low dose (2.5 mg) can also improve HDL levels.
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- Zetia and Vytorin, the pill that combines Zetia with a statin, are both sold by Merck&Co. of Whitehouse Station, New Jersey. Niaspan is made by North Chicago, Illinois-based Abbott Laboratories. All three of these drugs cost between $3 and $4 a day, though niacinhas been sold as a cheap generic for decades.
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ezetimibe (Zetia) Ezetimibe reduces the amount of cholesterol absorbed by the body. Ezetimibe is used to treat high cholesterol. Ezetimibe is sometimes given with other cholesterol-lowering medications. Ezetimibe may also be used for other purposes not listed in this medication guide.
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Questran Cholestyramine helps reduce cholesterol (fatty acids) in the blood. High cholesterol is associated with an increased risk of heart disease and atherosclerosis (clogged arteries). Cholestyramine is used to lower high levels of cholesterol in the blood, especially low-density lipoprotein (LDL) (bad cholesterol).
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Is Zetia a Statin? Zetia works in the intestines. It blocks the function of the protein that carries cholesterol through the wall of the intestine and into the blood stream. Zetia blocks the absorption of the cholesterol you eat, but still lowers cholesterol of those who adhere to a low cholesterol diet.
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Zetia and/or Statins: The Good, the Bad and the Ugly First off, Zetia isn't even a statin, although it is designed to have the same outcome as a statin—lower cholesterol. Zetia just does it in a different way. Ezetimibe (Zetia) is an anti-hyperlipidemic that blocks the absorption of cholesterol in the small intestine.
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Zetia Ezetimibe is usually taken once daily. Take the medicine at the same time each day. You may take this medicine with or without food. Ezetimibe may be taken at the same time with fenofibrate, or with a statin medication such as atorvastatin, lovastatin, simvastatin, pravastatin, or fluvastatin.
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- Like all statins, simvastatin is used to lower the amount of low-density lipoprotein (LDL) cholesterol—known as “bad cholesterol”—in the blood. And the 80 mg dose of simvastatin has been shown to lower LDL cholesterol by an additional 6% over the 40 mg dose.But myopathy can be debilitating. Moreover, a rare form of myopathy, called rhabdomyolysis, can lead to kidney failure and death.ut the risk is greater for patients who take the 80 mg doses of simvastatin, especially in the first year of treatment. Colman says the muscle damage is often caused by interactions with other medications.
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- This article is a collaboration between MedPage Today® and: The monoclonal antibody alirocumab, a PCSK9 inhibitor, significantly reduced LDL cholesterol when compared with ezetimibe (Zetia) in a phase III trial, top-line results released by the drug makers showed.