what causes scleroderma disease
629329be59c724ace7e9d09092379f77
Glossary for Autoimmune diseases Scleroderma, also known as systemic sclerosis, is a chronic systemic autoimmune disease characterised by hardening (sclero) of the skin (derma). In the more severe form, it also affects internal organs. Limited scleroderma involves cutaneous manifestations that mainly affect the hands, arms and face.eath occurs most often from lung, heart and kidney complications. In diffuse cutaneous disease, five-year survival is 70% and 10-year survival is 55%. The cause of scleroderma is unknown. It is an autoimmune condition, in which the body's immune system attacks healthy tissues.
2f1062e71d5a60901ae9614db3d7af50
Scleroderma CREST syndrome: A limited form of scleroderma, a disease of connective tissue that involves the formation of scar tissue (fibrosis) in the skin and sometimes also in other organs of the body.REST syndrome: A limited form of scleroderma, a disease of connective tissue that involves the formation of scar tissue (fibrosis) in the skin and sometimes also in other organs of the body.
1f38553dbc24492efd82a4fb3801b44f
- Systemic scleroderma is the most serious form of the disease, can affect the skin, muscles, joints, blood vessels, lungs, kidneys, heart and other organs. There are two major forms of systemic scleroderma: limited cutaneous systemic sclerosis (also called CREST syndrome) and diffuse cutaneous systemic scleroderma.
fa1c34c26d446d6b3ce4db14da6f372a
Scleroderma This form of scleroderma develops very slowly, causes few complications, and rarely spreads to other parts of the body. Another, more serious variant of the disease, is called Systemic scleroderma, or sclerosis, and can affect large areas of the skin as well as other organs such as the heart, lungs, and kidneys. There are actually two main types of systemic scleroderma, limited disease (CREST syndrome), and diffuse disease.Treatment.
3d61de1f0c592ab437b069bb32ddcbdc
- Overview of Scleroderma. Scleroderma, also called systemic sclerosis (SSc), is a chronic autoimmune disease that can affect a number of body systems (i.e., a multisystemic disorder).he disease is more common in adults between the ages of 30 and 50, and is 3 to 5 times more common in women than men. Scleroderma also may affect children and the elderly. The diffuse (widespread) form of the disease occurs more often in African American women than in Caucasian women.
af707c17ae102f67ae2b1a4aead7077e
Scleroderma The symptoms of scleroderma depend on the type of scleroderma present and the extent of external and internal involvement in the individual affected. Because scleroderma can involve the skin, esophagus, blood vessels, kidneys, lungs, blood pressure, and bowels, the symptoms it causes can affect many areas of the body.
b068597b64e012e44a73e4b2888666d8
Systemic Scleroderma Definition and etiology. Scleroderma, or systemic sclerosis (SSc), is a chronic multisystem autoimmune disease characterized by a vasculopathy, diffuse fibrosis of skin and various internal organs, and immune abnormalities.efinition and etiology. Scleroderma, or systemic sclerosis (SSc), is a chronic multisystem autoimmune disease characterized by a vasculopathy, diffuse fibrosis of skin and various internal organs, and immune abnormalities.
d4eebcaaab708e4d4300e8db52d6787c
- Scleroderma, a Greek word meaning hard skin, is a disease in which affected tissue hardens or thickens in response to the overproduction and accumulation of collagen, connective tissue that supports the skin and internal organs. Systemic scleroderma: With this type of scleroderma, blood vessels and internal organs in addition to the skin are affected. 2  Subcategories are defined by the specific body parts affected. 3  With systemic scleroderma, skin changes may develop suddenly and worsen progressively over a year or two.
a8e87f342e3fe8dfc7aa5607fe356d1d
- Autoimmune diseases occur when the immune system, which normally protects you from infections and cancer, makes a mistake and starts to damage your body’s own tissues. Morphea (syn. localized scleroderma) occurs as a result of autoimmune fibrosing (leather-like) injury to the skin and sometimes the underlying fat, muscle and bone.
c75aa667b2585fb2cc3db9b46a6defe4
Systemic scleroderma Systemic scleroderma is an autoimmune disorder that affects the skin and internal organs. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs.The word scleroderma means hard skin in Greek, and the condition is characterized by the buildup of scar tissue (fibrosis) in the skin and other organs.The condition is also called systemic sclerosis because the fibrosis can affect organs other than the skin.Fibrosis is due to the excess production of a tough protein called collagen, which normally strengthens and supports connective tissues throughout the body.he word scleroderma means hard skin in Greek, and the condition is characterized by the buildup of scar tissue (fibrosis) in the skin and other organs. The condition is also called systemic sclerosis because the fibrosis can affect organs other than the skin.
e96398a615f1bb1ca382a600c3172919
Defense of the Ancients Defense of the Ancients. Defense of the Ancients (DotA) is a multiplayer online battle arena mod for the video game Warcraft III: Reign of Chaos and its expansion, Warcraft III: The Frozen Throne. The objective of the game is for each team to destroy their opponents' Ancient, a heavily guarded structure at the opposing corner of the map, which is based on the Aeon of Strife map for StarCraft.
0ba488c784656a59515e2e2c5097af91
- Scleroderma is a rheumatic autoimmune disease that causes hardening of your skin and other tissues of your body. The word scleroderma means thick skin.. Autoimmune refers to a disease caused by your body mistakenly attacking its own healthy tissue. Rheumatic refers to a disease that causes inflammation.
30a8f3a2b53bc567a53f7937beaf7b46
Instantaneous Acceleration The acceleration of the object at an instant t i.e. instantaneous acceleration is nearly equal to average acceleration in small time interval $\Delta t$, because in this time interval the acceleration of the object can be considered to be uniform, even though the object has non-uniform acceleration.
66a832708c13a45ac1c1013dac8a3f7e
- 1 Scleroderma – this type of autoimmune disorder commonly affects the connective tissues of skin and blood vessels, muscles, and internal organs. 2  The disease usually affects women more commonly between ages 30 and 50 years.3  Dermatomyositis – this condition results in inflammation of muscles and a skin rash. Scleroderma – this type of autoimmune disorder commonly affects the connective tissues of skin and blood vessels, muscles, and internal organs. 2  The disease usually affects women more commonly between ages 30 and 50 years.
7ccf4b33e8c0090cfd8b6fa9d851ce1f
Scleroderma The cause of scleroderma is unknown. However, it is believed to be an autoimmune disease, meaning it occurs when the body’s immune system mistakenly attacks the its own cells and tissues. Scientists know that people with scleroderma overproduce collagen, a key component of connective tissue.
6db25459693404a4da2c1d03e1c4111d
- Scleroderma refers to a group of rare chronic autoimmune diseases in which the skin and connective tissues tighten and harden; it is a progressive disease. The skin and connective tissues are fibers that make up the framework that supports the body.t is worse for diffuse cutaneous scleroderma, especially for elderly male patients. Pulmonary, heart and/or kidney complications are the most common causes of death. A symptom is something the patient feels and reports, while a sign is something other people, such as the doctor detect.
b0bb2b6944c2ef4dfa205fc0745d98fe
Scleroderma Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. The disease can be either localized to the skin or involve other organs in addition to the skin. Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure. One form of the condition, known as CREST syndrome, classically results in calcium deposits, Raynaud's syndrome, esophageal problems, thi
b5b80ab863f792f54a9fe79c71fd6169
- Scleroderma mainly affects the blood vessels of kidneys. In scleroderma renal crisis, there is a sudden and severe rise in blood pressure and decline in kidney function over days or weeks. It may lead to complete kidney failure. It is not known what causes the crisis to develop.
63acc1e612d0dcae4d73f445a92bf8ba
What is scleroderma? Scleroderma, or systemic sclerosis, is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. The word “scleroderma” comes from two Greek words: “sclero” meaning hard, and “derma” meaning skin.
943e64727e0cc9314e373b224aa5c990
- Fast Facts: An Easy-to-Read Series of Publications for the Public. Scleroderma is a group of diseases that affect connective tissue in the body. This tissue supports your skin and internal organs.Scleroderma involves tissue that gets hard or thick. It can also cause swelling or pain in the muscles and joints.Some types of scleroderma lead to hard, tight skin.ast Facts: An Easy-to-Read Series of Publications for the Public. Scleroderma is a group of diseases that affect connective tissue in the body. This tissue supports your skin and internal organs. Scleroderma involves tissue that gets hard or thick. It can also cause swelling or pain in the muscles and joints.
1cbe726880693b3a2ddc026ace1a0504
- Often Raynaud's has no known cause. (This is sometimes called primary Raynaud's.). Raynaud's is usually a symptom of another disease, such as lupus, scleroderma, rheumatoid arthritis, or atherosclerosis.It may also be caused by taking certain medicines, using vibrating power tools for several years, smoking, or having frostbite.aynaud's is usually a symptom of another disease, such as lupus, scleroderma, rheumatoid arthritis, or atherosclerosis. It may also be caused by taking certain medicines, using vibrating power tools for several years, smoking, or having frostbite.
dbaa2fcf327c677d7732a6d35983cfce
Scleroderma Scleroderma is a progressive disease that affects the skin and connective tissue (including cartilage, bone, fat, and the tissue that supports the nerves and blood vessels throughout the body). There are two major forms of the disorder. The type known as localized scleroderma mainly affects the skin. Systemic scleroderma, which is also called systemic sclerosis, affects the smaller blood vessels and internal organs of the body. Description. Scleroderma is an autoimmune disorder, which means that the body's immune system turns against itself. In scleroderma, there is an overproduction of abnormal collagen (a type of protein fiber present in connective tissue). This collagen accumulates throughout the body, causing hardening (sclerosis), scarring (fibrosis), and other damage.
8efd507bdcdbc1dd1a747b1a9ca2a7ac
Scleroderma (Systemic Sclerosis): How It Affects The Body Scleroderma (Systemic Sclerosis): How It Affects The Body. Scleroderma, or systemic sclerosis, is a chronic connective tissue disease. It is generally classified as an autoimmune disease. The symptoms of scleroderma vary greatly from person-to-person, and not all patients develop all complications.
2402534eeff028ce0bd302631862488e
- 1 Fingers or toes. One of the earliest signs of scleroderma is an exaggerated response to cold temperatures or emotional distress, which can cause numbness, pain or color changes in the fingers or toes. Called Raynaud's disease, this condition also occurs in people who don't have scleroderma.  Digestive system.
f5cdc58abd5c42efa6f4412b27cb0d4f
Systemic Sclerosis (Scleroderma) NOTE: This is the Professional Version. Systemic sclerosis (SSc) is a rare chronic disease of unknown cause characterized by diffuse fibrosis, degenerative changes, and vascular abnormalities in the skin, joints, and internal organs (especially the esophagus, lower GI tract, lungs, heart, and kidneys).
d7d42c92aeeb2ab4973755aa78e4dfec
Understanding Scleroderma The cause of scleroderma is unknown and there is currently no cure, but there are treatments that can effectively prevent or limit the damage caused by this chronic disease. Who gets SCLERODERMA? Only a few people get scleroderma, but no one really knows why.