most common platinum-based chemotherapy for nsclc
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Lung Cancer - Non-Small Cell Chemotherapy Drugs and Regimens. Most chemotherapy regimens use platinum compounds, either cisplatin (Platinol) or carboplatin (Paraplatin). The preferred regimen uses two drugs -- one of which is a platinum-based drug. Combinations may include paclitaxel (Taxol) and carboplatin or cisplatin.
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Pembrolizumab Overall 13.5% of patients are recorded as receiving treatment with curative intent, 52.2% treatment with palliative intent and 17.7% supportive care only. In 16.3% no treatment was specified or data were missing. Surgery is the mainstay of treatment with curative intent for NSCLC. Overall resection rate for patients with proven NSCLC is 14% [2].
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DoxilÂ®/GemzarÂ® Effective for Recurrent Ovarian Cancer Researchers from Austria recently conducted a clinical trial to evaluate Gemzar plus Doxil in patients with ovarian cancer that has stopped responding to prior therapy with a standard platinum chemotherapy agent (Platinol or Paraplatin). This study included 31 patients. 1  Anticancer responses occurred in 33% of patients. 2  Complete disappearances of detectable cancer occurred in 20% of patients. 3  Half of the patients were alive with no cancer progression at nearly four months. 4  Half of the patients were alive at nearly 16 months.
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Types of Metamorphic Rocks Quartzite is a tough stone composed mostly of quartz. It may be derived from sandstone or from chert by regional metamorphism. (more below). Quartzite forms in two different ways. In the first way, under the pressures and temperatures of deep burial, sandstone or chert recrystallizes resulting in a metamorphic rock.A quartzite in which all traces of the original grains and sedimentary structures are erased may also be called metaquartzite.This Las Vegas boulder is a metaquartzite.more below). Quartzite forms in two different ways. In the first way, under the pressures and temperatures of deep burial, sandstone or chert recrystallizes resulting in a metamorphic rock. A quartzite in which all traces of the original grains and sedimentary structures are erased may also be called metaquartzite.
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- What FOLFOX is effective for and why. The FOLFOX chemotherapy regimen was designed and is used almost strictly in patients with advanced, metastatic colorectal cancer. The combination chemotherapy regimen known as FOLFOX consists of the following drugs: FOLolinic acid (leucovorin)
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Chemotherapy for multiple myeloma A typical treatment regimen for multiple myeloma . Many multiple myeloma patients receive chemotherapy in combination with other drugs/treatments to fight the disease and prevent recurrence. A typical multiple myeloma treatment plan may include: Induction chemotherapy (a combination of drugs used to destroy as many myeloma cells as possible). Consolidation chemotherapy (high doses of chemotherapy to destroy any remaining myeloma cells) followed by a single or tandem stem cell transplant.
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- The overall 5-year survival for small-cell lungcancer (SCLC) is 3.5%, or 2.5% in limited-stage diseaseand 1.2% in extensive-stage disease [53]. Non-small cell lung cancer In early stage disease, either radical surgery or radicalradiotherapy can result in long-term cure. StageIeIIIAZ21% (Australia); 35% (SEER).
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speed To increase the speed or rate of; accelerate. Often used with up: speed up a car; sped up production. 3. To further, promote, or expedite (a legal action, for example).
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Targeted therapy Targeted therapies may also be described as chemotherapy or non-cytotoxic chemotherapy, as chemotherapy strictly means only treatment by chemicals. But in typical medical and general usage chemotherapy is now mostly used specifically for traditional cytotoxic chemotherapy. Bevacizumab (marketed as Avastin) targets circulating VEGF ligand. 2  It is approved for use in the treatment of colon cancer, breast cancer, non-small cell lung cancer, and is investigational in the treatment of sarcoma. 3  Its use for the treatment of brain tumors has been recommended.
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Lung Cancer Treatment For limited stage disease (confined to the chest), chemotherapy and radiation therapy are used as curative treatments. 1  For extensive stage SCLC, chemotherapy alone is the mainstay of therapy. 2  For limited or extensive stage, the radiation oncologist may suggest radiation therapy directed at the brain even though no cancer has been found there.
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Opdivo The approval of TECENTRIQ in these patients is based on a study that measured response rate and duration of response. There is an ongoing study to confirm clinical benefit. a type of lung cancer called non-small cell lung cancer (NSCLC). TECENTRIQ may be used when your lung cancer*: has spread or grown, and. you have tried chemotherapy that contains platinum, and it did not work or is no longer working.
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Non-Small Cell Lung Cancer Treatment In stage IV lung cancer, chemotherapy is typically the main treatment. In stage IV patients, radiation is used only for palliation of symptoms. The chemotherapy treatment plan for lung cancer often consists of a combination of drugs. Among the drugs most commonly used are cisplatin (Platinol) or carboplatin (Paraplatin) plus docetaxel (Taxotere), gemcitabine (Gemzar), paclitaxel (Taxol and others), vinorelbine (Navelbine and others), or pemetrexed (Alimta).
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Avastin Â®  (bevacizumab) Metastatic colorectal cancer (mCRC) for first- or second-line treatment in combination with intravenous 5-fluorouracil–based chemotherapy. Advanced nonsquamous non–small cell lung cancer (NSCLC)in combination with carboplatin and paclitaxel in people who have not received chemotherapy for their advanced disease.
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- Class Summary. Cisplatin, carboplatin, and paclitaxel are chemotherapy agents approved for the initial treatment of ovarian cancer. Intrastrand cross-linking of DNA and inhibition of DNA precursors are among proposed mechanisms of action for cisplatin. The mechanism of action for paclitaxel is tubulin polymerization and microtubule stabilization.
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Original StudyLong-term Outcomes of Induction Carboplatin and Gemcitabine Followed by Concurrent Radiotherapy With Low-dose Paclitaxel and Gemcitabine for Stage III Nonâsmall-cell Lung Cancer Concurrent chemo-radiation is the standard therapy for patients with stage III NSCLC. • Induction carboplatin and gemcitabine followed by radiation with low-dose paclitaxel and gemcitabine may be an appealing alternative treatment. •
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Investigational EGFR Inhibitor May Hold Promise for Some Patients With Treatment-Resistant NSCLC Key Points: 1  AZD9291 is a third-generation oral, irreversible, selective inhibitor of EGFR mutations that are both activating and resistant, which means it can disable the challenging T790M mutation responsible for 50% of acquired resistance to anti-EGFR treatment in advanced non–small cell lung cancer patients.Assuming that human tumors and biomarkers behave in a similar way to those in mouse xenografts, these simulations suggest that a dose of 7 to 17 mg of AZD9291 once a day would be efficacious in patients with advanced NSCLC harboring the EGFR-activating and T790M (resistant) mutations,” Dr. Galbraith said.
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- Platinum based chemotherapy drugs are known to be rather tough to endure in terms of side effects. Arguably, cisplatin is regarded as the platinum drug with the most severe side effects, including neurotoxicity, nephrotoxicity (kidney damage), ototoxicity (hearing damage), nausea and vomiting,
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- ALIMTA is not indicated for patients who have a different type of NSCLC called squamous cell. ALIMTA is a treatment for malignant pleural mesothelioma (MPM), which is a cancer that affects the inside lining of the chest cavity.ALIMTA is given with cisplatin, another anticancer medicine (chemotherapy), when surgery is not an option. ALIMTA can suppress bone marrow function, which may cause low blood cell counts.LIMTA is not indicated for patients who have a different type of NSCLC called squamous cell. ALIMTA is a treatment for malignant pleural mesothelioma (MPM), which is a cancer that affects the inside lining of the chest cavity.
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War of the Checkpoint Inhibitors: Anti-PD-1 Drugs Move into First-Line Treatment in NSCLC Credit: Ventana Medical Systems Inc. Last year, the U.S. Food and Drug Administration (FDA) approved two anti-PD-1 checkpoint inhibitors, a type of immunotherapy, for treatment of non-small cell lung cancer (NSCLC) in patients whose cancer has progressed after first-line treatment with chemotherapy.
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Chemotherapy Medicines Depending on the characteristics of the cancer, a targeted therapy medicine, such as Herceptin (chemical name: trastuzumab), may be used in combination with some chemotherapy regimens. For example, the TCH regimen includes Taxotere, Herceptin, and carboplatin. Your doctor may talk about certain groups of chemotherapy medicines: 1  Anthracyclines are chemically similar to an antibiotic. Anthracyclines damage the genetic material of cancer cells, which makes the cells die. 2  Taxanes interfere with the way cancer cells divide. Taxol, Taxotere, and Abraxane are taxanes.
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Avastin Â®  (bevacizumab) Recurrent ovarian cancer (rOC). Avastin in combination with paclitaxel, pegylated liposomal doxorubicin or topotecan, is approved to treat platinum-resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer (prOC) in women who received no more than two prior chemotherapy treatments.
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Chemotherapy Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. This type of chemotherapy is used for curative intent. Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, and/or hyperthermia therapy.
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Platinum-based antineoplastic Cisplatin is particularly effective against testicular cancer; the cure rate was improved from 10% to 85%. 1  Approved platinum-based anticancer drugs. 2  cisplatin. 3  Carboplatin. 4  Oxaliplatin. 5  Nedaplatin.
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Prostate Cancer: Treatment Options The goal of systemic therapy for stage IV NSCLC is to keep the disease from growing and spreading. Patients must be prepared to have treatment on and off for the rest of their lives to control the disease. An important part of cancer care is relieving a person’s symptoms and side effects.
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- AZACITIDINE is a chemotherapy drug. This medicine reduces the growth of cancer cells and can suppress the immune system. It is used for treating myelodysplastic syndrome or some types of leukemia. Compare nucleoside metabolic inhibitors.
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14 FAQs About Chemotherapy for Ovarian Cancer Chemotherapy is usually recommended after surgery for most stages of ovarian cancer. A combination of chemotherapy medications is typically used. The primary goal of chemotherapy is to destroy cancer cells by preventing them from growing and dividing rapidly and to bring about cancer remission.