what causes low alk phosphatase
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Hypophosphatasia In adults, prior treatment with anti-resorptive therapy is a common cause of low alkaline phosphatase. However, in the context of the appropriate clinical setting, a low alkaline phosphatase is strong evidence for a diagnosis of HPP.. Dr. Tebben explains: When interpreting the result of an alkaline phosphatase measurement, it is crucial to utilize the appropriate age and gender-specific reference ranges.
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Elevated Alkaline Phosphatase In disease states: 1  Liver and bile diseases: Elevated ALP levels are known to occur in conditions like liver cirrhosis, stone or tumor in the gall bladder, tumor in the liver, cholestasis, cholecystitis, cholangitis, hepatitis and fatty liver syndrome.
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Alkaline phosphatase Alkaline phosphatase. Alkaline phosphatase (ALP, ALKP, ALPase, Alk Phos) (EC 3.1.3.1) or basic phosphatase is a homodimeric protein enzyme of 86 kilodaltons, containing two zinc atoms crucial to its catalytic function per monomer, and is optimally active at alkaline pH environments.
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- An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream. The test requires a simple blood draw and is often a routine part of other blood tests.Abnormal levels of ALP in your blood most often indicate a problem with your liver and/or bones.However, they may also indicate malnutrition, kidney tumors, or a serious infection. The normal range of ALP varies from person to person and depends on your age, blood type, and sex.Find an internist near you ».hen the results of your ALP test are in, your doctor will discuss them with you and tell you what to do next. According to Cigna, the normal levels for an adult are between 25 and 100 units of ALP per liter of blood. The normal value for a child is up to 350 units per liter (Cigna, 2010).
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ALP (Alkaline Phosphatase Level) Test An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream. The test requires a simple blood draw and is often a routine part of other blood tests.Abnormal levels of ALP in your blood most often indicate a problem with your liver and/or bones.However, they may also indicate malnutrition, kidney tumors, or a serious infection.lkaline phosphatase is an enzyme found in your bloodstream. ALP helps break down proteins in the body and exists in different forms, depending on where it originates. It is mostly produced in your liver, but some is also made in your bones, intestines, and kidneys.
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- When the alkaline phosphatase (ALP) test result is high, you may need to have the ALP isoenzyme test. This test will help determine what part of the body is causing higher ALP levels. It may also be done to check liver function and to see how medicines you take may affect your liver.
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Medical Dictionary A test for alkaline phosphatase (ALP) is done to: 1  Check for liver disease or damage to the liver.  Check bone problems (sometimes found on X-rays), such as rickets, bone tumors, Paget's disease, or too much of the hormone that controls bone growth (parathyroid hormone).
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- Mixed: In these clinical syndromes, neither aminotransferase nor alkaline phosphatase elevations are clearly predominant. Symptoms may also be mixed. Drugs such as phenytoin can cause this type of injury.
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Understanding Lab Tests: Entire Lesson Hepatitis C. Alkaline phosphatase (often shortened to alk phos) is an enzyme made in liver cells and bile ducts. The alk phos level is a common test that is usually included when liver tests are performed as a group. Hepatitis C treatment usually does not affect alk phos levels. 2  Alk phos is produced in other organs besides the liver--it is also found in the bones and the kidneys. 3  If your alk phos level is high, your doctor will probably order additional tests to determine why.
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- A study examined causes for low serum alkaline phosphatase (ALP) activity in a large Veterans Medical Center were reviewed. 1  1) Lum G. Significance of low serum alkaline phosphatase activity in a predominantly adult male population.Clin Chem. 1995 Apr;41(4):515-8.  2) Shaver WA et al.
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What Are the Symptoms and Treatments for High Alkaline Phosphatase Levels? Quick Answer. Because an elevated alkaline phosphatase, or ALP, level can be associated with different medical conditions like rickets, cirrhosis, hepatitis, bone cancer, Paget's disease, hyperparathyroidism and a deficiency in vitamin D, symptoms and treatment options are different and dependent on the specific cause, as noted by WebMD.
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What Causes Low Alkaline Phosphatase? Alkaline phosphatase -- commonly abbreviated as ALP -- is a protein found in all cells of the body. The highest concentrations of ALP are located in cells of the liver, bones and bile ducts. ALP in the blood is primarily derived from excess ALP that is released from these cells. Blood levels of ALP are often measured as part of routine blood tests. Although many conditions, including liver and bone diseases, can cause high levels of ALP, low blood ALP levels are uncommon.
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- A test for alkaline phosphatase (ALP) is done to: 1  Check for liver disease or damage to the liver. 2  Check bone problems (sometimes found on X-rays), such as rickets, bone tumors, Paget's disease, or too much of the hormone that controls bone growth (parathyroid hormone).lkaline Phosphatase. Guide. An alkaline phosphatase (ALP) test measures the amount of the enzyme ALP in the blood. ALP is made mostly in the liver and in bone with some made in the intestines and kidneys. It also is made by the placenta of a pregnant woman. The liver makes more ALP than the other organs or the bones.
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- Nazario: During the first six weeks of development the fetus depends on the maternal supply of thyroid hormone for development of the brain and nervous system. Only after six weeks is the fetus capable of supplying its own source of thyroid hormone. During pregnancy, a hypothyroid patient, one who has inappropriate levels of thyroid hormone, can have a few complications. A TSH should be checked during the first trimester and should be monitored every eight to 12 weeks.
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Do Certain Foods Raise Alkaline Phosphatase Levels? Alkaline phosphatase, or ALP, is a protein found in all body tissues. The bones, liver and bile ducts usually contain higher concentrations of ALP than other body tissues.Normal ALP levels range from a low of 44 international units per liter to a high of 147 International Units per Liter, according to MedlinePlus.he bones, liver and bile ducts usually contain higher concentrations of ALP than other body tissues. Normal ALP levels range from a low of 44 international units per liter to a high of 147 International Units per Liter, according to MedlinePlus.
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- Main symptoms of low alkaline phosphatase. Low alkaline phosphatase can produce symptoms such as fatigue, tachycardia (a pulse of more than 120 beats per minute), shortness of breath, intolerance to cold, constipation or major weight loss.
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What  Does Your Blood Test Mean? Alkaline Phosphatase: Alkaline phosphatase is an enzyme that is found in all body tissue, but the most important sites are bone, liver, bile ducts and the gut. A high level of alkaline phosphatase in your blood may indicate bone, liver or bile duct disease.Certain drugs may also cause high levels.ransaminases (SGTP) & (SGOT): These are enzymes that are primarily found in the liver. Drinking too much alcohol, certain drugs, liver disease and bile duct disease can cause high levels in the blood. Hepatitis is another problem that can raise these levels. Low levels of GGTP may indicate a magnesium deficiency.
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Elevated Alkaline Phosphatase Alkaline phosphatase is an enzyme commonly found in many human tissues, predominantly in the liver, bones, placenta, intestines and kidneys. Its function is to remove the phosphate group from proteins and other bio-molecules, and is called ‘alkaline’ phosphatase as it required a basic pH for optimal activity.
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Alkaline Phosphatase Blood Test: What Does Elevated Alkaline Phosphatase Mean? Alkaline phosphatase (ALP) is an important enzyme found throughout the body including the intestines, kidneys, liver, bones, and in the placenta of pregnant women. However, the bone and liver contain the highest concentrations of ALP in the body because they are the organs that greatly manufacture the enzyme. ALP is needed in liver physiology and bone development. (1). The blood contains ALP, which amount is maintained at a particular range of values.
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Understanding Lab Tests: Entire Lesson Explanation of test results: A high alk phos level does not reflect liver damage or inflammation. A high alk phos level occurs when there is a blockage of flow in the biliary tract or a buildup of pressure in the liver--often caused by a gallstone or scarring in the bile ducts.
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Medical Dictionary A test for alkaline phosphatase (ALP) is done to: 1  Check for liver disease or damage to the liver. 2  Check bone problems (sometimes found on X-rays), such as rickets, bone tumors, Paget's disease, or too much of the hormone that controls bone growth (parathyroid hormone). test for alkaline phosphatase (ALP) is done to: 1  Check for liver disease or damage to the liver. 2  Check bone problems (sometimes found on X-rays), such as rickets, bone tumors, Paget's disease, or too much of the hormone that controls bone growth (parathyroid hormone).
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Elevated Alkaline Phosphatase & Cancer Medically Reviewed by. Brenda Spriggs, MD, MPH, MBA. Alkaline phosphatase, or ALP, is an enzyme that is responsible for cleaving phosphate groups from other molecules, such as nucleotides, which are building blocks for DNA, and proteins.
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Alkaline Phosphatase  [en EspaÃ±ol] An alkaline phosphatase (ALP) test measures the amount of the enzyme ALP in the blood. ALP is made mostly in the liver and in bone with some made in the intestines and kidneys.
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Understanding Lab Tests: Entire Lesson 1 Hepatitis C treatment usually does not affect alk phos levels. 2  Alk phos is produced in other organs besides the liver--it is also found in the bones and the kidneys. 3  If your alk phos level is high, your doctor will probably order additional tests to determine why.
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What Are the Causes of low Alkaline Phosphatase? Alkaline phosphatase can also indicate a liver dysfunction or severe liver failure, which can be caused by cirrhosis (the condition in which the cells are destroyed by the liver), or hepatitis (liver inflammation).
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What Does High Alkaline Phosphatase Mean on Blood Tests? High alkaline phosphatase levels can be associated with various liver diseases such as as hepatic cancer, cirrhosis, fatty liver and hepatitis. Doctors will usually run a liver panel blood test-- also called a hepatic function test.