what are bisphosphonates
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- Bisphosphonates and cancer. Bisphosphonates are drugs that slow down or prevent bone damage. They also lower calcium levels. How cancer can affect the bones. Some cancers can cause bone pain and weakness. These are most often cancers that have started in another part of the body and have spread to the bone (secondary bone cancer).
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Bisphosphonate Treatment in Osteoporosis: Optimal Duration of Therapy and the Incorporation of a Drug Holiday Bisphosphonates are the most widely used treatment for osteoporosis. They accumulate in the bone for years, and therefore, their inhibitory effects on osteoclasts may persist after drug discontinuation. The ideal duration of therapy remains controversial.
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- In general, earth pressure acting on exterior basement walls is assumed to be earth pressure at rest. At depths below the groundwater level, the influence of hydraulic pressure is taken into consideration, and if there is surcharge on the ground surface, its influence is also taken into account.
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Boniva For Patients. Boniva (ibandronate) is a bisphosphonate drug that alters the cycle of bone formation and breakdown in the body used to treat or prevent osteoporosis in women after menopause. Boniva slows bone loss while increasing bone mass, which may prevent bone fractures. Side effects of Boniva include: back pain,
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Bisphenol A BPA is employed to make certain plastics and epoxy resins. BPA-based plastic is clear and tough, and is made into a variety of common consumer goods, such as water bottles, sports equipment, CDs, and DVDs.isphenol A is an endocrine disruptor that can mimic estrogen and has been shown to cause negative health effects in animal studies. To be specific, bisphenol A closely mimics the structure and function of the hormone estradiol with the ability to bind to and activate the same estrogen receptor as the natural hormone.
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Benefits and risks of osteoporosis drugs Alendronate (Fosamax, Fosamax Plus D, and generic), the first bisphosphonate approved by the Food and Drug Administration for the treatment and prevention of osteoporosis, came on the market in 1995 and proved to be a moneymaker, bringing in nearly $3.2 billion in 2005.
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Can't Take a Bisphosphonate? Prolia May Be Right For You Like bisphosphonates, Prolia focuses on osteoclasts, cells that break down your bones, causing them to “shed” and lose density. But it does it in a different way: by targeting a protein called RANK ligand, which controls the activity of osteoclasts.
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Denosumab (aka Prolia, Xgeva) â Even Worse than the Bisphosphonates? The problem with denosumab and all the drugs currently available is that they are for short term use (so will only, at best, postpone your risk of a major fracture for a few years), and, these drugs come with risk for significant adverse side effects. Denosumab, like the bisphosphonates, works by preventing osteoclasts from doing their necessary job of removing old, brittle bone, so it can be replaced with new, healthy bone.
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Bisphosphonate drug holiday: who, when and how long Bisphosphonates have been widely used in the treatment of osteoporosis with robust data from numerous placebo-controlled trials demonstrating efficacy in fracture risk reduction over 3–5 years of treatment.
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Issues related to diagnosis and treatment of bisphosphonate-induced osteonecrosis of the jaws The first injectable form of bisphosphonate, pamidronate, was approved for the treatment of bone metastases in 1991, and the more potent zolendronic acid received approval 10 years later. 17 A third injectable agent, ibandronate, was approved for use in osteoporosis patients in 2006.31.he first description of exposed, nonhealing bone in the mouths of patients receiving intravenous (IV) bisphosphonate medication was in a 2002 textbook by Marx and Stern; 12 however, the relationship between bisphosphonate use and bone exposure was not fully appreciated at that time.
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- With the antiresorptive medicines (bisphosphonates, calcitonin, estrogen, estrogen agonists/antagonists and denosumab), the goal of treatment is to prevent further bone loss and to reduce the risk of fractures. Fractures can cause deformities, disabilities, and serious, as well as life threatening complications.
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Phosphonate Phosphonate salts are the result of deprotonation of phosphonic acids, which are diprotic acids: Phosphonate esters are the result of condensation of phosphonic acids with alcohols. Several methods exist for the preparation of phosphonic acids and their salts.
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Bisphenol A Bisphenol A (BPA) is a chemical used to make polycarbonate plastic. Polycarbonate plastic is used to make hard plastic items, such as baby bottles, re-useable water bottles, food containers, pitchers, tableware and other storage containers.You can also find polycarbonate plastic in eyeglass lenses, CDs, DVDs, computers, appliances, sports safety equipment and many other products.PA is also used to make epoxy resins. Epoxy resin linings coat the inside of metal products such as food cans, bottle tops and water supply pipes. The purpose of epoxy linings is to keep the can material from corroding or reacting with the food.
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5 Popular Osteoporosis Drugs: Safe or Dangerous? Some bisphosphonates, such as Fosamax (alendronate) and Actonel (risedronate), are taken as a daily or weekly tablet, while Boniva (ibandronate) is taken monthly to prevent and treat osteoporosis. Reclast (zoledronic acid) is taken intravenously once a year to treat osteoporosis and every two years to help prevent it.
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Bisphenol-A (BPA) Bisphenol-A (BPA) Bisphenol A or BPA, is a chemical used to make plastics including materials that come into contact with food such as refillable drinks bottles and food storage containers. It's also used to make protective coatings and linings for food and drinks cans.
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Osteoporosis - Medications Some medicines slow the rate of bone loss or increase bone thickness. Even small amounts of new bone growth can reduce your risk of broken bones. Bisphosphonates. These include alendronate (Fosamax), ibandronate (Boniva), risedronate (Actonel), and zoledronic acid (Reclast).
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- Their effect is dose dependent and they reduce the turnover of bone by inhibiting recruitment and promoting apoptosis of osteoclasts. Bisphosphonates are used to treat postmenopausal and glucocorticoid induced osteoporosis, Paget's disease of bone and malignant hypercalcemia. There are a few bisphosphonates available and one might work better for a particular condition, than the other.
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Fosamax DRUG DESCRIPTION. FOSAMAX (alendronate sodium) is a bisphosphonate that acts as a specific inhibitor of osteoclastmediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.
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What are Bisphosphonates? Bisphosphonates are medications that used to treat bone loss and are the most common agent to be prescribed for osteoporosis. These drugs can also reduce fracture risk in cases of previous fracture. Bisphosphonates are medications that used to treat bone loss and are the most common agent to be prescribed for osteoporosis. These drugs can also reduce fracture risk in cases of previous fracture. Bone is constantly undergoing a turnover process in which osteoblasts create bone and osteoclasts destroy it. Bisphosphonates inhibit the actions of osteoclasts by promoting their apoptosis (programmed cell death), which, in turn, slows bone loss.
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- Its most commonly reported side-effect is a 10% incidence of upper GI symptoms including heartburn or gastroesophageal reflux. The dosing schedule and potential side-effect limit the use of this drug in some patients. One way to potentially achieve the benefits of a bisphosphonate without the GI side-effects or dosing issues is to use an intravenous bisphosphonate. Pamidronate, another bisphosphonate commonly used in the treatment of elevated calcium levels associated with cancer, can be used for the treatment of osteoporosis. It is often given intravenously at three month intervals and has been shown in several small studies to reduce the rates of bone loss.
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zoledronic acid (Reclast, Zometa) Reclast (zoledronic acid - sometimes called zoledronate) is in a group of medicines called bisphosphonates (bis FOS fo nayts). Zoledronic acid inhibits the release of calcium from bones. Reclast is used to treat Paget's disease, and to treat or prevent osteoporosis in postmenopausal women or people who take certain steroid medicines. Reclast is also used to increase bone mass in men with osteoporosis.
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- Bisphenol A (BPA) is used primarily to make polycarbonate plastic and epoxy resins, and is integral to the manufacture of both materials. Both polycarbonate and epoxy are unique and versatile materials that out-perform other materials in a broad range of end-uses providing consumers with a unique range of properties not available in other materials.
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- Bisphenol A is a chemical found in polycarbonate plasticand epoxy resins. Polycarbonate plastics are used in certain food and drink packaging and also in compact discs, computers, impact-resistant safety equipment (such as helmets and goggles), and medical devices.
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- Alendronic acid, also known as alendronate sodium, is an oral bisphosphonate that helps prevent bone loss and rebuild and strengthen bones where risk of deterioration or fracture is present.Alendronic acid tablets are relatively new to the market, released in 2008 under the brand name Fosamax.Alendronic acid is administered in different doses as prescribed by a doctor, generally over the long term.It's advised that the medication be taken with a full glass of water and that patients avoid lying down for 30 minutes afterward.lendronic acid tablets are relatively new to the market, released in 2008 under the brand name Fosamax. Alendronic acid is administered in different doses as prescribed by a doctor, generally over the long term.
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Bisphenol A Bisphenol A is an organic synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. It is a colorless solid that is soluble in organic solvents, but poorly soluble in water. It has been in commercial use since 1957. BPA is employed to make certain plastics and epoxy resins. BPA-based plastic is clear and tough, and is made into a variety of common consumer goods, such as water bottles, sports