what causes elevated alkaline phosphatase levels in the body
1eef70a00dc9df7931fff5a98fdb1da5
- Elevated alkaline phosphatase levels are associated with a higher risk for heart disease. In a prospective study of more than 3000 elderly men, the higher alkaline phosphatase levels predict higher risks of heart attacks, strokes, and increase mortality (R).
069c9a40ed281bf6a8c863fe1b8187f5
- While alkaline phosphatase may not necessarily cause harm to the body itself, elevated levels are associated with cancer, bone, liver, and kidney diseases (R). High liver alkaline phosphatase levels are associated with bile duct obstruction and liver cancer. The presence of liver alkaline phosphatase in patients may indicate the presence of a tumor in the bile duct (R).
a4645aa871bcb79221ed0f47416d76d8
- The alkaline phosphatase test (ALP) is used to help detect liver disease or bone disorders. 1  In conditions affecting the liver, damaged liver cells release increased amounts of ALP into the blood. This test is often used to detect blocked bile ducts because ALP is especially high in the edges of cells that join to form bile ducts.
29b4841a3e1d1df2cc321e5f4946d043
- A decreased serum alkaline phosphatase may be due to: 1  Zinc deficiency. 2  Hypothyroidism. 3  Vitamin C deficiency/Scurvy. 4  Folic acid deficiency. 5  Excess Vitamin D intake. 6  Low phosphorus levels (hypophosphatasia) 7  Celiac disease. 8  Malnutrition with low protein assimilation (including low stomach acid production/hypochlorhydria).
de12e5d4ea04842ea2560b7e215a2dad
Interpreting an isolated raised serum alkaline phosphatase level in an asymptomatic patient If alkaline phosphatase is raised in an asymptomatic patient and serum bilirubin, liver transaminases, creatinine, adjusted calcium, thyroid function, and blood count are normal: Consider growth spurts in adolescents, pregnancy in women, drugs, and age related increases.
fa547acf084a169ba54efd9ef4d93fce
What Causes Low Alkaline Phosphatase? Alkaline phosphatase -- commonly abbreviated as ALP -- is a protein found in all cells of the body. The highest concentrations of ALP are located in cells of the liver, bones and bile ducts. ALP in the blood is primarily derived from excess ALP that is released from these cells. Blood levels of ALP are often measured as part of routine blood tests. Although many conditions, including liver and bone diseases, can cause high levels of ALP, low blood ALP levels are uncommon.
4ab2d1d5e82af64dc54f09eac6573f58
- Elevated Alkaline Phosphatase & Cancer. Alkaline phosphatase, or ALP, is an enzyme that is responsible for cleaving phosphate groups from other molecules, such as nucleotides, which are building blocks for DNA, and proteins.
637ea527f4c1b0c1801ed66ca4593837
Alkaline Phosphatase Alkaline Phosphatases are a group of enzymes found primarily the liver (isoenzyme ALP-1) and bone (isoenzyme ALP-2). There are also small amounts produced by cells lining the intestines (isoenzyme ALP-3), the placenta, and the kidney (in the proximal convoluted tubules). What is measured in the blood is the total amount of alkaline phosphatases released from these tissues into the blood.
419c50f4384043d4ae623876facbcfe2
Alkaline Phosphatase An increased serum Alkaline Phosphatase may be due to: Congestion or obstruction of the biliary tract, which may occur within the liver, the ducts leading from the liver to the gallbladder, or the duct leading from the gallbladder through the pancreas that empty into the duodenum (small intestine).
2d5781971874e16b0293ea7e040b5b2b
Elevated Alkaline Phosphatase The laboratory test for elevated levels of alkaline phosphatase (ALP) is a diagnostic for detection of liver and bone disorders. The levels of this enzyme can increase due to physiological as well as pathological causes. Read on to find out all about ALP and the implications of increased ALP levels.
36ec52a64c053df833c1ff0992ee8efd
- When the alkaline phosphatase (ALP) test result is high, you may need to have the ALP isoenzyme test. This test will help determine what part of the body is causing higher ALP levels. It may also be done to check liver function and to see how medicines you take may affect your liver.
45d69220920b52c0f2fbbc60abcf8a05
- High ALP usually means that either the liver has been damaged or a condition causing increased bone cell activity is present. If other liver tests such as bilirubin, aspartate aminotransferase (AST), or alanine aminotransferase (ALT) are also high, usually the increased ALP is coming from the liver.
aa2b75be29141f07c3f133bdb3321002
Alkaline Phosphatase Low There are also a few more serious conditions which can give rise to low alkaline phosphatase levels. In all cases, when a blood test indicates low alkaline phosphatase levels, further diagnostic procedures are indicated to discover the reason for the result and allow for appropriate treatment.
4345f46c3f0fad5766b6f0ecd730d209
What Are the Causes of low Alkaline Phosphatase? Alkaline phosphatase can also indicate a liver dysfunction or severe liver failure, which can be caused by cirrhosis (the condition in which the cells are destroyed by the liver), or hepatitis (liver inflammation). Both vitamin B12 and iron deficiency anaemia types often involve having low levels of alkaline phosphatase.
48e035e6207a1f3ba24048d72a4e8cde
- Alkaline phosphate(ALP) is found in the liver and bone. ALP (related to bone disorders) is elevated with normal bone growth, pathological new bone growth with osteoblastic tumors(bone cancer), Pagets disease, healing fractures and rheumatoid arthritis.
7aa39bb95c8be1f5c8dae1cb163b6d1a
What Low Alkaline Phosphatase Levels Mean for You What Low Alkaline Phosphatase Levels Mean for You. Alkaline phosphatase is an enzyme that is involved in the production of bone, so it is found at higher levels in children than in adults. The enzyme is primarily produced in mucosal cells that line the bile duct. Low alkaline phosphatase levels are linked to a wide range of conditions. slide 1 of 5.
08806e05313250e1b6e8a3683280aca8
Alkaline Phosphatase Blood Test: What Does Elevated Alkaline Phosphatase Mean? Alkaline phosphatase (ALP) is an important enzyme found throughout the body including the intestines, kidneys, liver, bones, and in the placenta of pregnant women. However, the bone and liver contain the highest concentrations of ALP in the body because they are the organs that greatly manufacture the enzyme. ALP is needed in liver physiology and bone development. (1). The blood contains ALP, which amount is maintained at a particular range of values.
3bd02a13094e2a53946219eeb733a348
- The alkaline phosphatase (ALP) test measures how much alkaline phosphatase you have in your blood. Alkaline phosphatase is an enzyme found throughout your body. But it is mainly in your liver, bone, kidney, and digestive tract.
010b2effb4d212a38b7f1f5756892edf
Elevated alkaline phosphatase The following are the most common treatments of elevated alkaline phosphatase. 1  Treatment of the underlying condition.  Once doctors identifies the cause of elevated ALP and diagnose a treatment, the levels of alkaline phosphatase fluctuates back to normal.
6eae2ab3c287d91e0ffec96f9cb9d2de
- The alkaline phosphatase (ALP) test measures how much alkaline phosphatase you have in your blood. Alkaline phosphatase is an enzyme found throughout your body. But it is mainly in your liver, bone, kidney, and digestive tract.f your ALP levels are too high, your health care provider may order an ALP isoenzyme test to find out what type of ALP is elevated in your blood. Liver disorders make different forms of ALP than bone disorders.
05a1096b0a1c1096e7043ae66a26cbfc
Alkaline Phosphatase  [en EspaÃ±ol] If the ALP level is high, more tests may be done to find the cause. The amounts of different types of ALP in the blood may be measured and used to determine whether a high level is from the liver or bones. This is called an alkaline phosphatase isoenzymes test.
c6b1621447f0593a4b16a63710b1f8a4
- ^ Back To Top. Alkaline Phosphatase is a metabolic enzyme present in your body. It is primarily present in the liver tissue, GI tract, and bone tissue. Physicians often test your blood for levels of Alkaline Phosphatase to assess whether or not you have liver damage.
b7ae8ad00ab05c33ca5c545862f494a8
ALP (Alkaline Phosphatase Level) Test Alkaline phosphatase is an enzyme found in your bloodstream. ALP helps break down proteins in the body and exists in different forms, depending on where it originates. It is mostly produced in your liver, but some is also made in your bones, intestines, and kidneys. In pregnant women, ALP is made in the placenta.
65a8ee05878877a0f9c7f5102ed519b7
- When the alkaline phosphatase (ALP) test result is high, you may need to have the ALP isoenzyme test. This test will help determine what part of the body is causing higher ALP levels. This test may be used to diagnose or monitor: 1  Bone disease.  Liver, gallbladder, or bile duct disease.
cf8e5fe863efee079bec448f091e86a5
- An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream. The test requires a simple blood draw and is often a routine part of other blood tests.Abnormal levels of ALP in your blood most often indicate a problem with your liver and/or bones.However, they may also indicate malnutrition, kidney tumors, or a serious infection. The normal range of ALP varies from person to person and depends on your age, blood type, and sex.Find an internist near you ».hen the results of your ALP test are in, your doctor will discuss them with you and tell you what to do next. According to Cigna, the normal levels for an adult are between 25 and 100 units of ALP per liter of blood. The normal value for a child is up to 350 units per liter (Cigna, 2010).
81deafe6b172c8a52a7387ea7f007e8f
- If your ALP level is high, your doctor may have you take another test, called an ALP isoenzyme test, to determine whether the alkaline phosphatase in your blood is coming from your liver or your bones. WebMD Medical Reference Reviewed by Neha Pathak, MD on January 30, 2017.
a241e35b97ba0c744482403046d9e057
- High levels in your blood could mean you have liver damage. Alkaline phosphatase (ALP) test. ALP is an enzyme you have in your liver, bile ducts, and bone. You might have high levels if you have liver damage or disease, a blocked bile duct, or bone disease. Albumin and total protein test.