why does diabetes cause tissue damage
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Diabetic tissue damage may be explained by controversial theory Hyperglycemia does it by increasing the rate of transformation of NAD to NADH. Hypoxia makes it difficult for cells to turn NADH back to NAD. In both conditions the increased NADH is recycled back to NAD by processes that produce free radicals, chemically reactive compounds that can damage tissue. Williamson and his coauthors propose that long-term use of these processes causes the damage seen in diabetes.
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Diabetes and Inflammation How Inflammation Develops. People with type 2 diabetes don't produce enough insulin or their bodies can't use the insulin adequately. Insulin is a hormone that is made by cells in the pancreas.It controls the amount of sugar in the blood. Insulin may also have an impact on tissue in the body.ow Inflammation Develops. People with type 2 diabetes don't produce enough insulin or their bodies can't use the insulin adequately. Insulin is a hormone that is made by cells in the pancreas.
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- It can be caused by either autoimmune destruction of cells in the pancreas (type 1) or. the inability of tissues such as the muscles and liver to properly use insulin (type 2). Diabetes. can result in complications such as heart disease, stroke, hypertension, and nerve damage.
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What Is Type 1 Diabetes (Juvenile)? Unfortunately, undiagnosed or prolonged high blood sugar levels can result in damage to organ systems in the body over time. People with type I diabetes have a high risk of vision problems, heart disease, stroke, kidney failure, gum disease, tooth loss, and nerve damage (especially in the hands and feet).nfortunately, undiagnosed or prolonged high blood sugar levels can result in damage to organ systems in the body over time. People with type I diabetes have a high risk of vision problems, heart disease, stroke, kidney failure, gum disease, tooth loss, and nerve damage (especially in the hands and feet).
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Contents Therefore, diabetes can lead to a lot of complications related to the blood vessels, which include: 1  Poor vision. 2  An increased risk of heart attack or stroke. 3  High blood pressure.  Retention of body water, which may lead to ankle 1  swelling. Kidney failure.  Foot 1  ulcers. Damaged nerves.
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Diabetes and Inflammation As type 2 diabetes starts to develop, the body becomes less sensitive to insulin and the resulting insulin resistance also leads to inflammation. A vicious cycle can result, with more inflammation causing more insulin resistance and vice versa. Blood sugar levels creep higher and higher, eventually resulting in type 2 diabetes. Emotional stress can also increase levels of the chemicals of inflammation.
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Impaired Tissue Perfusion Conclusions. The research reviewed in this article suggests that impaired tissue perfusion due to abnormality of the microvascular system is common among the conventional cardiovascular risk factors, including hypertension, diabetes, obesity, and dyslipidemia.n additional factor that influences local tissue perfusion is blood rheology. The apparent viscosity of blood depends on several factors, including hematocrit, red blood cell deformability and aggregation, and leukocyte activation.
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About diabetes Complications of diabetes. Diabetes complications are divided into microvascular (due to damage to small blood vessels) and macrovascular (due to damage to larger blood vessels).tiology. Diabetic kidney disease is also caused by damage to small blood vessels in the kidneys. This can cause kidney failure, and eventually lead to death. In developed countries, this is a leading cause of dialysis and kidney transplant.
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How Does Diabetes Affect Blood Vessels? A healthy endothelium is necessary for blood to flow freely in your blood vessels. High blood sugar in diabetes damages the endothelium. This impairs the steady flow of blood inside blood vessels. Diabetes decreases the release of Nitric Oxide from blood vessels.
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Overview Damage to nerves and blood vessels. Prolonged exposure to high blood sugar can damage delicate nerve fibers, causing diabetic neuropathy. Why this happens isn't completely clear, but a combination of factors likely plays a role, including the complex interaction between nerves and blood vessels.High blood sugar interferes with the ability of the nerves to transmit signals.hy this happens isn't completely clear, but a combination of factors likely plays a role, including the complex interaction between nerves and blood vessels. High blood sugar interferes with the ability of the nerves to transmit signals.
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- 1 Nerve damage in legs. 2  Severe depression (in cases of very high blood sugar levels) 3  Non-healing wounds;infection is increased as the excess sugar feeds fungal and bacterial invaders.  Tissue damage (due to oxidizing [burning] effect of the excess sugar in the tissue)
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Diabetes: Skin Conditions Diabetic dermopathy — Diabetes can affect the small blood vessels of the body that supply the skin with blood. Changes to the blood vessels because of diabetes can cause a skin condition called diabetic dermopathy. Dermopathy appears as scaly patches that are light brown or red, often on the front of the legs.The patches do not hurt, blister or itch, and treatment generally is not necessary.iabetes can cause two problems that can affect your feet: 1  Diabetic neuropathy — Uncontrolled diabetes can damage your nerves. 2  If you have damaged nerves in your legs and feet, you might not feel heat, cold or pain.
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- Diabetes is a serious disease that can affect different parts of your body through its complications. Diabetes can damage your eyes, heart and blood vessels, kidneys, nerves, teeth and gums. Uncontrolled diabetes can lead to: heart attack. stroke. toe, foot, or leg infections requiring amputation. blindness.
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Diabetes 1 Diabetes can damage this delicate filtering system. Severe damage can lead to kidney failure or irreversible end-stage kidney disease, which requires dialysis or a kidney transplant.  Eye damage. Diabetes can damage the blood vessels of the retina (diabetic retinopathy), potentially leading to blindness. Diabetes also increases the risk of other serious vision conditions, such as cataracts and glaucoma.
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Diabetes and Foot Problems Over time, diabetes may cause nerve damage, also called diabetic neuropathy, that can cause tingling and pain, and can make you lose feeling in your feet. When you lose feeling in your feet, you may not feel a pebble inside your sock or a blister on your foot, which can lead to cuts and sores. Cuts and sores can become infected. Diabetes also can lower the amount of blood flow in your feet.
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Gangrene and Diabetes: Know the Facts Gangrene is a condition that occurs when your body tissue dies. This can happen when the blood flow to an area of the body is disrupted. Often, gangrene is the result of an injury or an infection of the skin and soft tissue. Gangrene typically affects the toes, fingers, and limbs. It can also affect your muscles or organs, but this isn’t as common.
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Diabetes - long-term effects Long-term effects of diabetes. damage to the small blood vessels, causing problems in the eyes, kidneys, feet and nerves (microvascular complications). Other parts of the body can also be affected by diabetes, including the digestive system, the skin, sexual organs, teeth and gums, and the immune system.
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- Diabetes complications are divided into microvascular (due to damage to small blood vessels) and macrovascular (due to damage to larger blood vessels).
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TYPE 2 DIABETES AND AMPUTATION Researchers are studying how prolonged exposure to high blood glucose causes nerve damage. Nerve damage is likely due to a combination of factors: metabolic factors, such as high blood glucose, long duration of diabetes, abnormal blood fat levels, and possibly low levels of insulin.
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Gestational Diabetes Quinoa Overview:: Type 1 diabetes can affect major organs in your body, including heart, blood vessels, nerves, eyes and kidneys.Keeping your blood sugar level close to normal most of the time can dramatically reduce the risk of many complications. Long-term complications of type 1 diabetes develop gradually, over decades. Heart and blood vessel disease. 2  Diabetes dramatically increases your risk of various cardiovascular problems, including coronary artery disease with chest pain (angina), heart attack, stroke, narrowing of the arteries (atherosclerosis) and high blood pressure.
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29 CFR 778.114 - Fixed salary for fluctuating hours. For the first week the employee is entitled to be paid $600; for the second week $600.00; for the third week $660 ($600 plus 10 hours at $6.00 or 40 hours at $12.00 plus 10 hours at $18.00); for the fourth week $650 ($600 plus 8 hours at $6.25, or 40 hours at $12.50 plus 8 hours at $18.75).f during the course of 4 weeks this employee works 40, 37.5, 50, and 48 hours, the regular hourly rate of pay in each of these weeks is $15.00, $16.00, $12.00, and $12.50, respectively.
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Lexapro vs. Effexor DRUG CLASS AND MECHANISM: Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressants used for treating depression, anxiety disorder, and pain.Other drugs in this class include milnacipran (Savella), venlafaxine (Effexor), and desvenlafaxine (Pristiq).RUG CLASS AND MECHANISM: Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressants used for treating depression, anxiety disorder, and pain.
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Why are people with diabetes prone to developing chronic wounds? Wound Healing in Diabetes. The diabetic ulcer is an excellent example of how multiple physiologic and biochemical defects can lead to impaired wound healing. Fifteen percent of patients suffering from DM will suffer a foot ulcer in their lifetime[1].
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Description Nerve damage (neuropathy) is a complication of diabetes that leads to a loss of sensation in the feet. Some people with diabetes can no longer feel when something has irritated or even punctured the skin. A wound as small as a blister can progress to a serious infection in a matter of days.
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Diabetes can affect almost all organ systems within the body Print Email. 2012-01-31T19:36:00Z Diabetes can affect almost all organ systems within the body By JASON COHEN, M.D. - Marcus Daly Memorial Hospital Ravalli Republic. January 31, 2012 7:36 pm • By JASON COHEN, M.D. - Marcus Daly Memorial Hospital. (0) Comments. One in eight Americans older than 20 has diabetes. Most of us know at least one person who has suffered from the complications of this disease. These complications can affect almost every organ system in the body, including the brain, heart, kidneys, eyes, nervous system, skin and soft tissues. If uncontrolled, diabetes can lead to stroke, heart attack, kidney failure, blindness, chronic pain and amputations.