what is agranulocytosis
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Agranulocytosis Print This Page. Agranulocytosis, also known as agranulosis or granulopenia, is a condition that occurs when the bone marrow (the soft tissue inside bones) fails to make enough white blood cells. This condition can cause a suppressed immune response to bacteria and other infections because white blood cells are a critical part of the human immune system.
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Aplastic anemia From Wikipedia, the free encyclopedia. Aplastic anemia (AA) is a disease in which the bone marrow, and the blood stem cells that reside there, are damaged. This causes a deficiency of all three blood cell types (pancytopenia): red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). Aplastic refers to inability of the stem cells to generate the mature blood cells.
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Elliptocytosis 1 Elliptocytosis 1: Introduction. Elliptocytosis 1: An inherited blood disorder where a significant number of red blood cells (erythrocytes) are elliptical or oval shaped rather than doughnut shaped. Anemia results when the abnormal red blood cells are destroyed. The severity of the anemia is variable with some cases resulting in fetal death and others being relatively asymptomatic.
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Clinical Medicine & Research The term macrocytosis refers to a blood condition in which red blood cells (RBC) are larger than normal. Macrocytosis is reported in terms of mean corpuscular volume (MCV).
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- AGRANULOCYTOSIS Because of a significant risk of agranulocytosis, a potentially life-threatening adverse effect, clozapine should be reserved for the use in the treatment of severely ill patients with schizophrenia who fail to show an acceptable response to adequate courses of standard antipsychotics drug treatment.GRANULOCYTOSIS Because of a significant risk of agranulocytosis, a potentially life-threatening adverse effect, clozapine should be reserved for the use in the treatment of severely ill patients with schizophrenia who fail to show an acceptable response to adequate courses of standard antipsychotics drug treatment.
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agranulocytosis \-ˌsēz\play. : an acute blood disorder that is marked by a decrease of circulating granulocytes (such as neutrophils) and is characterized especially by weakness, chills, swollen neck, sore throat, mouth ulcers, and jaundice ◆Agranulocytosis results from a decline in the production of granulocytes or from granulocyte destruction.
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Polycythemia Polycythemia (also known as polycythaemia or polyglobulia) is a disease state in which the proportion of blood volume that is occupied by red blood cells increases. Blood volume proportions can be measured as hematocrit level. A hematocrit of >55% is seen in polycythemia.
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Clozapine-Induced Agranulocytosis -- Incidence and Risk Factors in the United States The increasing risk of agranulocytosis with age and the reduced incidence after the first six months of treatment provide additional guidelines for the prescription and monitoring of clozapine treatment in the future.
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thrombocytosis Thrombocytosis is a blood disorder in which the body produces a surplus of platelets (thrombocytes). Thrombocytosis is an abnormally increased number of platelets in the blood. Platelets are blood cells that stick together, helping blood to clot. Thrombocytosis is a condition that may have many causes.
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- Therefore, children taking clozapine require frequent blood tests to monitor this potential side effect. Unfortunately, it has been difficult to study the long term safety of clozapine use, though one study of 172 children found that the risk of agranulocytosis was around 1% at 1 year, similar to the risk in adults.
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Macrocytosis Macrocytosis is the enlargement of red blood cells with near-constant hemoglobin concentration, and is defined by a mean corpuscular volume (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories).astrointestinal diseases that may cause macrocytosis include celiac disease (severe sensitivity to gluten from wheat and other grains that causes intestinal damage) and Crohn’s disease (inflammatory bowel disease that can affect any part of the gastrointestinal tract).
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Agranulocytosis and neutropenia (white blood cell deficiencies) Granulocytes are a type of white blood cell that help fight infection. 'Agranulocytosis' and 'neutropenia' are terms often used to describe a deficiency of these cells. However, the two terms shouldn't be used interchangeably, as they describe slightly different conditions. agranulocytosis is the term used when the bone marrow (soft tissue inside bone) fails to make enough granulocytes. neutropenia is the term used when the bone marrow fails to make enough of a specific group of granulocytes called neutrophils.
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Megaloblastic anemia Megaloblastic anemia (or megaloblastic anaemia) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis during red blood cell production.egaloblastic anemia not due to hypovitaminosis may be caused by antimetabolites that poison DNA production directly, such as some chemotherapeutic or antimicrobial agents (for example azathioprine or trimethoprim).
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Clinical Medicine & Research Macrocytosis due to vitamin B12 or folate deficiency is a direct result of ineffective or dysplastic erythropoiesis. These important vitamins and cofactors are required for normal maturation of all cells.
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Blood Hemoglobin is the protein that is responsible for turning megakaryocytes into doughnut-shaped red blood cells. Hemoglobin is the protein that is either found in decreased amounts or totally absent in persons with hemophilia.This deficiency prevents normal blood clotting. Hemoglobin, a protein found in white blood cells, carries oxygen from the lungs to the individual cells.[Return to the Top of this Page]: return.emoglobin is the protein that is responsible for turning megakaryocytes into doughnut-shaped red blood cells. Hemoglobin is the protein that is either found in decreased amounts or totally absent in persons with hemophilia.
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- It is a potent inducer of hepatic. enzymes, and thus reduces the plasma levels of many drugs including benzodiazepines, thyroxine, theophylline, and oestrogens, It may cause a chronically low white cell count and in 1 in 20,000. patients this can develop into agranulocytocis or aplastic anaemia.
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Anisocytosis Anisocytosis is a medical term meaning that a patient's red blood cells are of unequal size. This is commonly found in anemia and other blood conditions. False diagnostic flagging may be triggered by an elevated WBC count, agglutinated RBCs, RBC fragments, giant platelets or platelet clumps. In addition, it is a characteristic feature of bovine blood. The red cell distribution width (RDW) is a measurement of anisocytosis and is calculated as a coefficient of variation of the distribution of RBC volumes divided by the mean corpuscular volume (MCV) Anisocytosis is identified by RDW and is classified according to the size of RBC measured by MCV.
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Exclusively for Members of Texas Medical Association a type of supplemental insurance hospital indemnity plans pay out when a policyholder checks into a hospital for an overnight stay entitling him to claim a certain amount say $ 250 against the policy for each additional night s stay he can add another $ 250 on top
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Angle bisector theorem and conversely, if a point D on the side BC of triangle ABC divides BC in the same ratio as the sides AB and AC, then AD is the angle bisector of angle ∠ A. The generalized angle bisector theorem states that if D lies on the line BC, then
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- Polycythemia (also known as polycythaemia or polyglobulia) is a disease state in which the proportion of blood volume that is occupied by red blood cells increases.Blood volume proportions can be measured as hematocrit.olycythemia (also known as polycythaemia or polyglobulia) is a disease state in which the proportion of blood volume that is occupied by red blood cells increases.
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Agranulocytosis, Acquired Acquired agranulocytosis is a rare, drug-induced blood disorder that is characterized by a severe reduction in the number of white blood cells (granulocytes) in the circulating blood. The name granulocyte refers to grain-like bodies within the cell. Granulocytes include basophils, eosinophils, and neutrophils.
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Poikilocytosis Generally, poikilocytosis can refer to an increase in abnormal red blood cells of any shape where they make up 10% or more of the total population.
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- Granulocytopenia can therefore more specifically involve neutropenia (shortage of neutrophils), eosinopenia and/or basopenia. The term neutropenia is sometimes used interchangeably with granulocytopenia or agranulocytosis.
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Nucleated red blood cell A megaloblast is an unusually large erythroblast that can be associated with vitamin B 12 deficiency (caused by pernicious anemia or dietary insufficiency), folic acid deficiency, or both (such anemias are collectively called megaloblastic anemias).
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Macrocytosis and Macrocytic Anaemia Macrocytosis means that the red blood cells are larger than normal. Macrocytic anaemia occurs when there is also a fall in haemoglobin levels in the blood. Anaemia is usually defined as a haemoglobin level of at least two standard deviations below the mean for that age and sex.s a general rule, macrocytosis occurs when there are problems with the synthesis of the blood cells, as in vitamin B12 or folic acid deficiency, whilst microcytosis is associated with deficiency of haemoglobin production, such as iron deficiency or thalassaemia.
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Macrocytosis Macrocytosis is the enlargement of red blood cells with near-constant hemoglobin concentration, and is defined by a mean corpuscular volume of greater than 100 femtolitres. The enlarged erythrocytes are called macrocytes or megalocytes.