is gapdh a cell surface protein in humans?
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- 1 GAPDH was identified as a binding protein on the plasma membrane of CEM-SS leukemia cells for Bt18 parasporal protein. 2  The study demonstrated that GAPDH is reliable as reference gene for quantitative gene expression analysis in human diploid fibroblasts. GAPDH is an integral part of the sarcolemmal K(ATP)-channel protein complex, where it couples glycolysis with the K(ATP)-channel activity. 2  A decrease in the dehydrogenase activity of GAPDH was noted in Alzheimer disease.
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EPCAM gene The EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). This protein is found in epithelial cells, which are the cells that line the surfaces and cavities of the body.
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Light Reflectance Value Light Reflectance Value. Light Reflectance Value is a number assigned to the reflection of colors. For example, a white test card presents a value of 100%, whereas, light absorbing newspaper has a value of 60%.
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RHOA Ras homolog gene family, member A is a small GTPase protein in the Rho family. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. In humans, it is encoded by the gene RHOA. It acts upon several effectors. Among them, ROCK1 and DIAPH1 are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billions years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution.
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Cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Lactobacillus plantarum LA 318 recognizes human A and B blood group antigens The cell surface GAPDH of L. plantarum LA 318 was purified as described previously [15] . Adherence of the purified GAPDH to each ligand was performed in triplicate using a biosensor BIACORE 1000 (BIACORE K. K., Tokyo, Japan) that uses quantitative surface plasmon resonance (SPR) [16] , [17] , [23] and [24] .n conclusion, here we determined that the GAPDH of L. plantarum LA 318 was an adhesin recognizing blood group A and B expressed on the non-reducing terminal sugar chains of human colonic mucin, and that the trisaccharide structure was important in this adhesion.
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CD1 CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells.However their precise function is unknown.ypes [edit]. CD1 glycoproteins can be classified primarily into two groups which differ in their lipid anchoring. 1  CD1a, CD1b and CD1c (group 1 CD1 molecules) are expressed on cells specialized for antigen presentation.
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Cleavage of the Human Immunoglobulin A1 (IgA1) Hinge Region by IgA1 Proteases Requires Structures in the Fc region of IgA Secretory immunoglobulin A (IgA) protects the mucosal surfaces against inhaled and ingested pathogens. Many pathogenic bacteria produce IgA1 proteases that cleave in the hinge of IgA1, thus separating the Fab region from the Fc region and making IgA ineffective.he IgA1 proteases cleave in the hinge of IgA and secretory IgA H chains, generating Fab and Fc fragments and thus enabling the bacteria to circumvent the IgA-mediated host defense.
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The active-site and amino-terminal amino acid sequence of bovine intestinal alkaline phosphatase. A possible amino acid sequence deduced from the amino acid composition of an active-site tryptic peptide from human placental alkaline phosphatase is very similar to the bovine intestinal active-site sequence.
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- Summary. This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule.
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Immunoglobulin IgA Class The role of IgA in the Immune Response. IgA comprises approximately 15% of all immunoglobulins in healthy serum. Two IgA subtypes exist in humans, IgA1 und IgA2, while mice have only one subclass. They differ in their molecular mass of the heavy chains and in their concentration in serum. IgA in serum is mainly monomeric, but in secretions, such as saliva, tears, colostrums, mucus, sweat, gastric fluid, IgA is found as a dimer where they are connected by a joining peptide. Most IgA is present in secreted form.
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- 2 2. Why is the percentage similarity in the gene always lower than the percentage similarity in the protein for each of the species? 3. Draw a cladogram depicting the evolutionary relationships among all five species (including humans) according to their percentage similarity in the GAPDH gene.
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Dystrophin isoforms The Dp116 was detected by (Byers et al.) , using an antibody against the distal rod domain of dystrophin. Dp116 has been exclusively found in adult peripheral nerve, along the Schwann cell membrane (on Northern blots liver, brain, testes, lung, spleen, submaxillary gland, thyroid and kidney were negative).
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Hairline Lowering Surgery or Forehead Reduction Surgery Surgery may be an option for some tendon injuries, but this is often only considered as a last resort because it's not always effective and carries a risk of complications such as wound infections, scarring and rupturing of the affected tendon. Surgery can be used to: remove the damaged section of tendon.
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- Lumenally-oriented Golgi proteins were excluded because GFP folds poorly in the lumen of the yeast secretory pathway. One suitable marker was Sec7, an abundant protein that associates peripherally with late Golgi cisternae. Sec7 is concentrated on about half of the cisternae in a cell.
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- Ligands required on the. opposite sides of epithelial cell barriers (e.g. IgA, IgM) are transported there. by a process called transcytosis (74), and storage proteins (e.g. vitellogenin) are commonly targeted to vacuoles and storage granules (121).
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RHD (gene) RHD (gene) Rh blood group, D antigen also known as Rh polypeptide 1 (RhPI) or cluster of differentiation 240D (CD240D) is a protein that in humans is encoded by the RHD gene. The RHD gene codes for the RhD erythrocyte membrane protein that is the Rh factor antigen of the Rh blood group system. RHD has sequence similarity to RHCE, RhAG, RhBG, and RhCG and these five genes constitute the Rh family.
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- 1 Report homozygous mutations in the 15-hydroxyprostaglandin dehydrogenase gene in patients with primary hypertrophic osteoarthropathy. 2  Results demonstrate that 15-PGDH acts as a tumor suppressor in gastric cancer and provide further validation for 15-PGDH as a potential therapeutic target for gastric cancer. Genetic variants in HPGD encoding 15-PGDH, appear to modulate colorectal risk. 2  The present study appears to be the first to evaluate possible associations between genetic heterogeneity in HPGD and CRC risk. 3  Observational study of gene-disease association and gene-environment interaction.
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Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease. Peters J(1), Rittger A(1), Weisner R(1), Knabbe J(1), Zunke F(1), Rothaug M(1), Damme M(1), Berkovic SF(2), Blanz J(1), Saftig P(1), Schwake M(3). Author information:
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Cell Adhesion and Cell Communication In a gap junction, the lipid bilayer of adjacent cells is pierced through by proteins called connexons. These proteins group together and effectively form a group of communication tunnels between adjacent cells. © 2010 Nature Education All rights reserved.
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Protein Expression Skip to Main Content Area. The Human Protein Atlas (HPA) contains localisation and expression data for all human proteins in distinct tissues of the body. The following table provides a list of genes expressed in macrophages as annotated by the Human Protein Atlas resource.
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Forced interaction of cell surface proteins with Derlin-1 in the endoplasmic reticulum is sufficient to induce their dislocation into the cytosol for degradation Thus, forced interaction of cell surface proteins with Derlin-1 is sufficient to induce their degradation via ERAD. Taken together, these results suggest that the main role of US11 is to recruit MHC-I molecules to Derlin-1, which then mediates the dislocation of MHC-I molecules into the cytosol for degradation.
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- EpCAM (CD 326) is a human transmembrane 40 Kd glycoprotein epithelial adhesion molecule. The antigen is located on the cell membrane and within the cytoplasm of all non-squamous epithelial cells. This epithelial specific antigen is also present on carcinomas of various organs.
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- Host Cell Protein (HCP) Assay: Product Purity. Click to view a complete list of Applied Biomics HCP assays. Applied Biomics Host Cell Protein (HCP) assays using 2D DIGE followed by fluorescent Western blot offer significant ADVANTAGES over the ELISA and standard 2D Western blot, with the following applications: 1) Characterizations of the HCP antibodies.
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Cadmium, Vectorial Active Transport, and MT-3âDependent Regulation of Cadherin Expression in Human Proximal Tubular Cells It was shown that HK-2 cells have no expression of MT-3 and do not form domes in culture; whereas, the human proximal tubular (HPT) cells and HK-2 cells stably transfected with MT-3 [HK-2(MT-3)] form these structures.
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Target Cell Type-Dependent Modulation of Human Immunodeficiency Virus Type 1 Capsid Disassembly by Cyclophilin A â¿ â The binding of cyclophilin A (CypA) to the human immunodeficiency virus type 1 (HIV-1) capsid protein (CA protein) is required soon after virus entry into natural target cells.arget cell type-dependent modulation of human immunodeficiency virus type 1 capsid disassembly by cyclophilin A. Li Y, Kar AK, Sodroski J. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA.
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- -each monomer has binding sites for cell surface or for the extracellular matrix; -the cell surface binding site contains a short amino acid sequence RGDS (arginine, glycine, aspartic acid, serine) which is recognized by cell surface receptors binding fibronectin; there are other binding sites for GAG's and collagen.