what is macroglobulinemia
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Macroglobulinemia â Symptoms, Prognosis, Diagnosis, Treatment Macroglobulinemia is a kind of non-Hodgkin lymphoma. Macroglobulinemia denotes growth within the cavity of the bone marrow of an abnormal population of lymphocytes, a kind of white blood cell. These lymphocytes in the bone marrow impede with the normal bone marrow role.
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Hypergammaglobulinemia Hypergammaglobulinemia is a condition that is characterized by the increased levels of a certain immunoglobulin in the blood serum. The name of the disorder refers to an excess of proteins after serum protein electrophoresis (found in the gammaglobulin region). Most hypergammaglobulinemias are caused by an excess of immunoglobulin M (IgM), because this is the default immunoglobulin type prior to class switching.
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What Is a Serum Hemoglobin Test? Hemolytic Anemia. Hemolytic anemia is a blood disorder that occurs when red blood cells are destroyed faster than the bone marrow can make them. There are two types of hemolytic anemia: intrinsic, which is inherited, and extrinsic which can be caused by certain infections, medications or autoimmune disorders.
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Hypogammaglobulinemia Hypogammaglobulinemia: Hypogammaglobulinemia is listed as a type of (or associated with) the following medical conditions in our database: 1  Primary Immune Deficiency. 2  Immune disorders. 3  Immune deficiency conditions.  Immune system conditions.
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Hypergammaglobulinemia Most hypergammaglobulinemias are caused by an excess of immunoglobulin M (IgM), because this is the default immunoglobulin type prior to class switching. Some types of hypergammaglobulinemia are actually caused by a deficiency in the other major types of immunoglobulins, which are IgA, IgE and IgG. There are 5 types of hypergammaglobulinemias associated with hyper IgM.
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Hypogammaglobulinemia Hypogammaglobulinemia is a type of primary immunodeficiency disease in which not enough gamma globulins exist in the blood (thus hypo- + gamma + globulin + -emia). This entails that not enough antibodies exist, which impairs the immune system. Hypogammaglobulinemia is a characteristic of common variable immunodeficiency. 1 Terminology.
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Megaloblastic Anemia Megaloblastic anemia is a blood disorder in which there is anemia with larger-than-normal red blood cells. Anemia is a condition in which the body does not have enough healthy red blood cells.egaloblastic anemia is a blood disorder in which there is anemia with larger-than-normal red blood cells. Anemia is a condition in which the body does not have enough healthy red blood cells.
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Macrocytic anemia Both of these factors work to the opposite effect of larger cell size, to finally result in a total blood hemoglobin concentration that is less than normal (i.e., anemia). Macrocytic anemia is not a disease in the sense of having a single pathology, but is rather a condition.oth of these factors work to the opposite effect of larger cell size, to finally result in a total blood hemoglobin concentration that is less than normal (i.e., anemia). Macrocytic anemia is not a disease in the sense of having a single pathology, but is rather a condition.
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Hypogammaglobulinaemia A state of deficiency of plasma gamma globulins and impairment of antibody formation. The most common cause worldwide is malnutrition. Hypogammaglobulinaemia may be primary or secondary: The primary antibody deficiency syndromes are a rare group of disorders presenting at any age. In the primary form, there is a reduced rate of synthesis of gamma globulins, whereas the secondary form results from an increased rate of breakdown or loss of gamma globulins.
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WaldenstrÃ¶m macroglobulinemia Waldenstroem waldenström macroglobulinemia is a rare blood cell cancer characterized by an excess of abnormal white blood cells called lymphoplasmacytic cells in the bone. Marrow this condition is classified as a lymphoplasmacytic. lymphoma
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Kidney Disease (Nephropathy) Having small amounts of protein in the urine is called microalbuminuria. When kidney disease is diagnosed early, during microalbuminuria, several treatments may keep kidney disease from getting worse. Having larger amounts of protein in the urine is called macroalbuminuria. When kidney disease is caught later during macroalbuminuria, end-stage renal disease, or ESRD, usually follows. In time, the stress of overwork causes the kidneys to lose their filtering ability. Waste products then start to build up in the blood.
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gamma globulin An abnormal amount of gamma globulin in the blood, a condition known as hypergammaglobulinemia, may be indicative of a chronic infection or certain malignant blood diseases. There is also a rare inherited condition, agammaglobinemia, in which the body is unable to produce gamma globulin.a class of plasma proteins composed almost entirely of immunoglobulins, the proteins that function as antibodies. Gamma globulins, immunoglobulins, antibodies and antiserum are often used synonomously and interchangeably.. A protein fraction of blood serum containing many antibodies that protect against bacterial and viral infectious diseases. 2. A solution of gamma globulin prepared from human blood and administered for passive immunization against measles, German measles, hepatitis A, poliomyelitis, and other infections.
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Autoimmune Hemolytic Anemia Autoimmune Hemolytic Anemia. AIHA is a blood disease in which a person produces substances that cause their own body to destroy red blood cells, resulting in anemia. All blood cells are made in the bone marrow. This is the red, spongy part inside the bones.
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Macrocytic anemia Both of these factors work to the opposite effect of larger cell size, to finally result in a total blood hemoglobin concentration that is less than normal (i.e., anemia). Macrocytic anemia is not a disease in the sense of having a single pathology, but is rather a condition. As such, it is the class name for a set of pathologies that all produce somewhat the same red blood cell abnormality. Many specific pathologies are known which result in macrocytic-type anemias.
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What is Waldenstrom Macroglobulinemia? A feature of Waldenstrom’s is the overproduction by B cells of a protein called monoclonal immunoglobulin M (IgM, or macroglobulin) antibody, which circulates in the blood. The buildup of IgM can cause the blood to become too thick. This is called hyperviscosity.
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- Background. Macrocytosis is a term used to describe erythrocytes that are larger than normal, typically reported as mean cell volume (MCV) greater than 100 fL. The amount of hemoglobin increases proportionately with the increase in cell size.itamin B-12 deficiency is a cause of macrocytosis. Because DNA synthesis requires cyanocobalamin (vitamin B-12) as a cofactor, a deficiency of the vitamin leads to decreased DNA synthesis in the erythrocyte, thus resulting in macrocytosis.
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- Beta-globin is a component (subunit) of a larger protein called hemoglobin, which is located inside red blood cells. In adults, hemoglobin normally consists of four protein subunits: two subunits of beta-globin and two subunits of another protein called alpha-globin, which is produced from another gene called HBA.ore than 10 mutations in the HBB gene have been found to cause methemoglobinemia, beta-globin type, which is a condition that alters the hemoglobin within red blood cells.
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Coombs' Test The direct Coombs' is sometimes called the direct antiglobulin test. Both types of Coombs' test look for antibodies which may attack red blood cells and cause them to be destroyed. The direct Coombs' test may be used if doctors suspect a person is affected by a haemolytic anaemia.
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Macrocytic anemia In a macrocytic anemia, the larger red cells are always associated with insufficient numbers of cells and often also insufficient hemoglobin content per cell. Both of these factors work to the opposite effect of larger cell size, to finally result in a total blood hemoglobin concentration that is less than normal (i.e., anemia).
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Goodpasture syndrome Goodpasture syndrome (GPS; also known as Goodpasture’s disease, antiglomerular basement antibody disease, or anti-GBM disease) is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure.oodpasture syndrome (GPS; also known as Goodpasture’s disease, antiglomerular basement antibody disease, or anti-GBM disease) is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure.
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gamma globulin gamma globulin. 1. a class of plasma proteins composed almost entirely of immunoglobulins, the proteins that function as antibodies. Production of gamma globulin may be increased in the body when there is invasion by harmful microorganisms. An abnormal amount in the blood, a condition known as hypergammaglobulinemia, may be indicative of a chronic infection or certain malignant blood diseases.
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Plato Some info about Plato: - The best known ancient Greek philosopher-Student of Socrates; teacher of Aristotle-Wrote about 23 philosophical dialogues-Famous doctrines: the Theory of the Forms; the Immortality of the Soul; Knowledge is Justified True Belief-Western philosophy consists of a series of footnotes to Plato..ome info about Plato: - The best known ancient Greek philosopher-Student of Socrates; teacher of Aristotle-Wrote about 23 philosophical dialogues-Famous doctrines: the Theory of the Forms; the Immortality of the Soul; Knowledge is Justified True Belief-Western philosophy consists of a series of footnotes to Plato..
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Megaloblastic Macrocytic Anemias Key Points. 1  Megaloblasts are large nucleated RBC precursors with noncondensed chromatin. 2  The most common causes of megaloblastic, macrocytic anemia are deficiency or defective utilization of vitamin B12 or folate. 3  Do CBC, RBC indices, reticulocyte count, and peripheral smear.
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Cardio IQ Panel - What Are We Testing? Apolipoprotein B (ApoB) - LDL particle number. ApoB is a direct measurement of the number of lipoprotein particles. A high Apo B number indicates increased risk for heart disease. Certain medications, improved eating habits, increased physical activity, and loss of body fat are some of the ways to improve Apo.
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Overview The direct antiglobulin test (DAT) is used to determine whether red blood cells (RBCs) have been coated in vivo with immunoglobulin, complement, or both.
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Macrocytic anemia In contrast, in microcytic anemia, the erythrocytes are smaller than normal. In a macrocytic anemia the larger red cells are always associated with insufficient numbers of cells and often also insufficient hemoglobin content per cell.oth of these factors work to the opposite effect of larger cell size, to finally result in a total blood hemoglobin concentration that is less than normal (i.e., anemia). Macrocytic anemia is not a disease in the sense of having a single pathology, but is rather a condition.