parathyroid related peptide lung cancer
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Parathyroid hormone-related protein From Wikipedia, the free encyclopedia. Parathyroid hormone-related protein (or PTHrP) is a protein member of the parathyroid hormone family. It is occasionally secreted by cancer cells (breast cancer, certain types of lung cancer including squamous cell lung carcinoma).he protein was first isolated in 1987 by T.J. Martin's team at the University of Melbourne. Miao et al. showed that disruption of the PTHrP gene in mice caused a lethal phenotype and distinct bone abnormalities, suggesting that PTHrP has a physiological function.
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Parathyroids The vast majority of patients have benign disease involving one gland in about 90% of cases, whereas two or more glands (hyperplasia) may be abnormal in 10% of cases. Parathyroid cancer as a cause of hyperparathyroidism is extremely rare, and comprises less than 1% of all cases of hyperparathyroidism.
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- In addition, androgen-independent cells may overexpress Bcl-2. Prostate-cancer cells may develop neuroendocrine-like behavior. Neuroendocrine cells secrete neuropeptides that in-duce the growth of adjacent cells, and thus prostate cancer may survive therapeutic interventions.
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EGFR epidermal growth factor receptor [ (human)] 1 Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China. 2  Mutation of EGFR E21 is negatively correlated with TUBB3 gene expression in non-small cell lung cancer. Epidermal growth factor receptor mutation is associated with response to therapy in resected advanced non-small-cell lung cancer. 2  Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer. 3  EGFR activating mutations are associated with brain metastases in non-small lung cancer.
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- Polycyclic aromatic hydrocarbon (PAH) exposure and DNA adduct semi-quantitation in archived human tissues. Pratt MM, John K, MacLean AB, Afework S, Phillips DH, Poirier MC.Carcinogen-DNA Interactions Section, National Cancer Institute, Bldg 37, Rm 4032 NIH, 37 Convent Drive, Bethesda, MD 20892, USA.m2pratt@yahoo.com.he IHC photomicrographs reveal the ubiquitous nature of PAH-DNA adduct formation in human tissues as well as PAH-DNA adduct accumulation in specific, vulnerable, cell types. This semi-quantative method for PAH-DNA adduct measurement could potentially see widespread use in molecular epidemiology studies.
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The association between serum TSH concentration and thyroid cancer In addition, they found that the development of autonomous thyroid function (TSH<0.4 μU/ml) was associated with a reduction in the risk of papillary thyroid carcinoma. In this commentary, the evidence regarding the association between serum TSH and thyroid cancer is discussed placing these new findings into context.
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ACTION: Section 503 of the Act adds bronchiolo-alveolar carcinoma to the list of diseases that VA presumes result from exposure to radiation during active military service. This provision of the law is effective November 30, 1999. This document amends 38 CFR 3.309(d) to reflect these changes.
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lung cancer lung cancer, a pulmonary malignancy attributable in the majority of cases to cigarette smoking. Other predisposing factors are exposure to acronitrile, arsenic, asbestos, beryllium, chloromethyl ether, chromium, coal products, ionizing radiation, iron oxide, mustard gas, nickel, petroleum, uranium, and vinyl chloride.
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- THYROID FUNCTION TEST CPT CODES: 80091 Thyroid panel, includes Thyroxine, total (84436) and Thyroid hormone (T3 or T4) uptake or thyroid hormone binding ration (84479) 80092 Thyroid panel with TSH 84436 Thyroxine, total 84439 Thyroxine Free 84443 Thyroid Stimulating Hormone (TSH) 84479 Thyroid hormone (T3 or T4) uptake or thyroid hormone binding ratio (THBR) COVERED DIAGNOSIS: 193 Malignant neoplasm of thyroid gland 198.82 Secondary malignant neoplasm of genital organs 198.89 Secondary malignant neoplasm of other specified site 226 Benign neoplasm of thyroid glands
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- The major serum thyroid hormone-binding proteins are thyroxine-binding globulin [TBG or thyropexin], transthyretin [TTR or thyroxine-binding prealbumin (TBPA)], and albumin (HAS, human serum albumin) (10).
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Bone Diseases Parathyroid Tumor. A parathyroid tumor is a growth inside a parathyroid gland. Parathyroid tumors may cause increased levels of parathyroid hormones secreted by the parathyroid glands, leading to hyperparathyroidism.1  About this Condition. parathyroid tumor is a growth inside a parathyroid gland. The parathyroid glands are 4 small glands located in the neck near the thyroid gland. They are part of the endocrine system that regulates hormones in the body.
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Parathyroid hormone-related peptide: expression in prostate cancer bone metastases Parathyroid hormone-related peptide: expression in prostate cancer bone metastases. A A G Bryden, S Islam, A J Freemont, J H Shanks, N J R George and N W Clarke.xpression of parathyroid hormone-related protein and its receptor in bone metastases from prostate cancer. J Pathol 2000; 191: 170-174. Article MEDLINE. 27 Lee C et al. Expression of parathyroid hormone-like protein in prostate cancer and prostatic intraepithelial neoplasia. J Urol 1997; 157: (Suppl 4) 225.
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Parathyroid hormone-related protein purified from a human lung cancer cell line. A protein with biological activities similar to parathyroid hormone (PTH) has been purified from serum-free culture medium obtained from a human lung cancer cell line (BEN).A major protein band of 18 kDa was obtained on NaDodSO4/polyacrylamide gels, with faint bands at 35 kDa and 67 kDa.ntibody raised to a corresponding synthetic peptide recognized the PTH-related material but showed less than 1% cross-reactivity with human PTH amino-terminal peptides. BEN cells contained PTH DNA, but not PTH messenger RNA, indicating involvement of another gene.
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Endocrine-Related Cancer It is also recognized that genetics (family history), diet, and environmental factors can impact prostate cancer risk. In the human population, direct connections between endocrine disruptors (EDs) and prostate cancer risk have not been established.
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- 1] TLR4 (endotoxin) Hay dust TNF-[alpha] production in TNF[alpha] hypersensitivity pneumonitis Ozone Influx of inflammatory TLR4 cells in the lung Airborne PAHs PAH metabolites in urine, CYP1A1 DNA adducts, or GSTM1 measures of NAT2 genotoxicity GSTP1 EPHX1 Lung cancer GSTM1 Nitro-PAHs Genotoxic effects in NAT2 respiratory tract Ultraviolet light ...
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- Most parathyroid cancer signs and symptoms are caused by the hypercalcemia that develops. Signs and symptoms of hypercalcemia include the following: 1  Weakness. 2  Feeling very tired. 3  Nausea and vomiting. 4  Loss of appetite.5  Weight loss for no known reason. 6  Being much more thirsty than usual.ost parathyroid cancer signs and symptoms are caused by the hypercalcemia that develops. Signs and symptoms of hypercalcemia include the following: 1  Weakness. 2  Feeling very tired. 3  Nausea and vomiting. 4  Loss of appetite. 5  Weight loss for no known reason.
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Toxic Substances Portal - Trichloroethylene (TCE) There is strong evidence that trichloroethylene can cause kidney cancer in people and some evidence for trichloroethylene-induced liver cancer and malignant lymphoma. Lifetime exposure to trichloroethylene resulted in increased liver cancer in mice and increased kidney cancer and testicular cancer in rats.
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EGFR epidermal growth factor receptor [ (human)] 1 EGFR mutations are associated with non-small cell lung cancer. 2  Epidermal growth factor receptor gene mutations are associated with treatment response in advanced non-small cell lung cancer. 3  The epidermal growth factor receptor (EGFR) is over-expressed in 40-80% of patients with non-small-cell lung cancer (NSCLC). Epidermal growth factor receptor mutation is associated with response to therapy in resected advanced non-small-cell lung cancer. 2  Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer. 3  EGFR activating mutations are associated with brain metastases in non-small lung cancer.
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Growth Hormone Implicated in Deadly Lung Cancer In previous work, such drugs have been shown to block the growth of bone cancers, brain cancers, small-cell and non-small-cell lung cancers, as well as cancers of the prostate, kidney, pancreas, and breast.
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College Costs in Florida Our guide surveyed tuition data from the 180 colleges and universities in Florida, the most popular being University of Florida with 42,949 full time students and an in-state tuition list price of $4,477. Rollins College is the most expensive in Florida with an in-state tuition of $43,080.Click on any school for current tuition, future cost estimates, school specific savings plans and estimated student loan payments. Florida colleges can also be filtered by public, private, community colleges and four year schools.ollins College is the most expensive in Florida with an in-state tuition of $43,080. Click on any school for current tuition, future cost estimates, school specific savings plans and estimated student loan payments.
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Human T-lymphotropic virus The human T-lymphotropic virus or human T-cell lymphotropic virus (HTLV) family of viruses are a group of human retroviruses that are known to cause a type of cancer called adult T-cell leukemia/lymphoma and a demyelinating disease called HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). virus closely related to HTLV-I, also discovered by Robert Gallo and colleagues, HTLV-II shares approximately 70% genomic homology (structural similarity) with HTLV-I.
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Radiologic Aspects of Immune-Related Tumor Response Criteria and Patterns of Immune-Related Adverse Events in Patients Undergoing Ipilimumab Therapy OBJECTIVE. The objective of this article is to illustrate examples of radiologic immune-related response criteria and toxicity in patients with advanced melanoma treated with the immunotherapeutic agent ipilimumab.CONCLUSION.Novel immune-related tumor response criteria should be applied to patients undergoing therapy with ipilimumab for advanced melanoma. Ipilimumab also produces a spectrum of immune-related adverse effects that can be recognized radiologically.ONCLUSION. Novel immune-related tumor response criteria should be applied to patients undergoing therapy with ipilimumab for advanced melanoma. Ipilimumab also produces a spectrum of immune-related adverse effects that can be recognized radiologically.
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- Cancer Therapy Vol 6, page 695 695 Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. New Engl J Med 322, 1106-1112. Carbone PP, Frost JK, Feinstein AR (1970) Lung cancer: perspectives and prospects.ancer Therapy Vol 6, page 695 695 Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. New Engl J Med 322, 1106-1112. Carbone PP, Frost JK, Feinstein AR (1970) Lung cancer: perspectives and prospects.
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Paracrine signalling Paracrine signaling of growth factors between nearby cells has been shown to exacerbate carcinogenesis. In fact, mutant forms of a single RTK may play a causal role in very different types of cancer. The Kit proto-oncogene encodes a tyrosine kinase receptor whose ligand is a paracrine protein called stem cell factor (SCF), which is important in hematopoiesis (formation of cells in blood).
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Growth Hormone Implicated in Deadly Lung Cancer Growth hormone is released from the pituitary gland, but how it plays a role in causing tumors is unknown. However, one important observation from this study is that GHRH is present elsewhere in the body, not just in the pituitary. Compared with disease-free mice, mice bearing the human lung cancers had higher levels of growth hormone-releasing hormone.
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Funded Research Project: To develop components of a virus that will be designed to kill neuroendocrine cancer cells. The virus will be modified to attach to somatostatin receptors on pancreatic neuroendocrine tumor cells, limiting negative effects on healthy tissues. Research Objectives: Design and construct octreotide-targeted AAVP gene delivery vector containing TNF-α. 1  Verify specific binding and gene delivery to evaluate the targeting properties of octreotide in a bacteriophage system. 2  Assess anti-tumor activity of octreotide-targeted AAVP delivering TNF-α in pancreatic NETs using the MEN1 mouse model.