which statins are most lipophilic
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Non-PCa Prescription Drugs: Statins - Lipophilic or Hydrophilic? Statins are sometimes described as being either lipophilic (hydrophobic) or hydrophilic (lipophobic) as though that were a binary condition. While Pravastatin is extremely hydrophilic, fluvastatin is an example of a statin occupying an intermetiate position. Hydrophilic statins: Pravastatin & Rosuvastatin (Crestor) Lipophilic: Lovastatin and Simvastatin are the most lipophilic. Atorvastatin & Cerivastatin less so. I have seen Fluvastatin placed in both categories. The lipophilic statins tend to increase insulin resistance, which may be a significant issue in PCa, IMO.
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Statin Several combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. In 2005, sales were estimated at US$18.7 billion in the United States. The best-selling statin is atorvastatin, which in 2003 became the best-selling pharmaceutical in history.
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- Statins are the most effective drugs for lowering bad cholesterol (LDL cholesterol). They achieve this by inhibiting the amount of cholesterol produced by the liver. In the Netherlands around 40 percent of the population over the age of 65 take statins, with close to 600,000 taking the medication.
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Effect of Lipophilic and Hydrophilic Statins on Breast Cancer Risk in Thai Women: A Cross-sectional Study Among statin users, 4624 (77%) women were prescribed a lipophilic statin, whereas 1,391(23%) women were prescribed a hydrophilic statin. Characteristics between lipophilic and hydrophilic statin user and non-user groups are presented in Table 1.
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5 Reasons to Stop or Switch Statins Statinsa class of drug that includes atorvastatin (Lipitor), simvastatin (Zocor), and othersare among the most effective drugs for lowering cholesterol.
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- Lipophilic. 1  Corynebacterium uropygiale. 2  Corynebacterium jeikeium. 3  Corynebacterium urealyticum. 4  Corynebacterium afermentans subsp. lipophilum. 5  Corynebacterium accolens. 6  Corynebacterium macginleyi. 7  CDC coryneform groups F-1 and G. 8  Corynebacterium bovis.
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Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events The mean age of the patients was 58 years, and 80.4% had at least one cardiovascular risk factor (Table 2). A total of 3128 patients (70.1%) were receiving statin therapy at the start of the OSLER trials. Premature permanent discontinuation of evolocumab occurred in 7.2% of patients.
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Statins May Reverse Plaque Buildup Atherosclerosis, the buildup of fatty plaque, calcium, and other deposits in arteries, is the most common cause of heart disease and death in the U.S. The new study builds on previous work by Nissen and colleagues that showed that the statin drug Lipitor can slow the progression of atherosclerosis basically to zero..
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- Moreover, atrial fibrillation is the most common arrhythmia encountered in the clinical practice. The beneficial effect of statins on cardiovascular morbidity and mortality is well-established, while the exact role of this class of drugs against arrhythmias remains unclear.
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- Inflammation is another important factor in the development of colorectal cancer, and statin anti-inflammatory effects might be another avenue for preventing colorectal cancer, particularly that associated with inflammatory-bowel-disease-associated colorectal cancer.
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- Statins (or HMG-CoA reductase inhibitors) are a class of drugs that reduce cholesterol in individuals who have dyslipidemia (abnormal fats in the blood) and thus are at risk for cardiovascular dise... Read the Statins (How They Work, Side Effects and Interactions) article 1  ». « Previous.2  1.any drugs can interact with lovastatin, including (but not limited to) cholestyramine (Questran), colestipol (Colestid), danazol (Danocrine), gemfibrozil (Lopid), and fenofibrate (Tricor). Patients taking Mevacor should be sure to tell their doctor about all the prescription and over-the-counter medications used.
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- The IL-6-mediated activation of STAT3 conferred partial but marked protection against SFN-induced apoptosis as evidenced by cytoplasmic histone-associated DNA fragmentation and cleavage of poly(ADP-ribose) polymerase and procaspase-3.
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Ezetimibe (Zetia): a new type of lipid-lowering agent After adding ezetimibe 10 mg/day to ongoing statin mono-therapy, an additional mean LDL cholesterol reduction of 25.1% was seen, while addition of placebo reduced the LDL cholesterol level by 3.7% (P < 0.001). Maximal effect was seen at week 2 and was maintained throughout the 8-week treatment period.
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Atorvastatin Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body. Atorvastatin was discovered by Bruce Roth and coworkers at Parke-Davis, since acquired by Warner-Lambert and then Pfizer.
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What Is Lipitor (Atorvastatin)? Among more than 470,000 patients newly treated with a statin, researchers found that the drug class is associated with a 10 to 22 percent increased risk for type 2 diabetes. Lipitor and Crestor presented the highest diabetes risk at 22 and 18 percent, respectively.
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Confirmed Again: Statin Drugs Accelerate Cardiovascular Disease Statins are the world's most-prescribed class of medications. A staggering one in four Americans over the age of 45 now take cholesterol-lowering drugs such as Pravachol, Mevacor, Lipitor, Zocor, Crestor, and others. A majority of them are taking these drugs for primary prevention of heart attacks and strokes.
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- This interaction is especially strong with simvastatin (Zocor) and lovastatin (Altoprev), milder with atorvastatin (Lipitor), and nonexistent for pravastatin (Pravachol), so it’s important for elders to check whether their prescribed statin drugs do interact before giving up vitamin C-rich grapefruit.
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ObamaCare Facts 2018 â We Tell you the Facts, Not The Talking Points But what if you don’t have insurance? To help pay for the cost of health insurance, you may be eligible for financial assistance from the government, called a subsidy. A health care subsidy is financial assistance from the government that you could be eligible for to help you pay for health insurance.
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- Lipitor is part of a class of drugs called statins (or HMG-CoA reductase inhibitors). It works by blocking a particular enzyme, HMG-CoA reductase, that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. Decreases triglycerides.
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Statins (How They Work, Side Effects and Interactions) Statins (or HMG-CoA reductase inhibitors) are a class of drugs that reduce cholesterol in individuals who have dyslipidemia (abnormal fats in the blood) and thus are at risk for cardiovascular disease.
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Statins & Irreversible Muscle Damage, ALS-Like Syndrome and Myositis For decades we have been receiving messages from people who have experienced devastating and debilitating muscle damage from their use of drugs like atorvastatin (Lipitor), rosuvastatin (Crestor) and simvastatin (Zocor). By 2007 we had names for these reactions: ALS-like syndrome, necrotizing myopathy and myositis.
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Statins: Side effects, uses, and risks By reducing blood cholesterol levels, statins lower the risk of chest pain (angina), heart attack, and stroke. Several types of statins exist such as atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin.Atorvastatin and rosuvastatin are the most potent, while fluvastatin is the least potent.everal types of statins exist such as atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin. Atorvastatin and rosuvastatin are the most potent, while fluvastatin is the least potent.
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rosuvastatin (Crestor) Rosuvastatin is in a group of drugs called HMG CoA reductase inhibitors, or  statins .. Rosuvastatin reduces levels of bad cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of good cholesterol (high-density lipoprotein, or HDL).
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- It's important to remember that statins may also interact with other medications you take. Examples of statins include: 1  Atorvastatin (Lipitor). 2  Fluvastatin (Lescol). 3  Lovastatin (Mevacor). 4  Pitavastatin (Livalo). 5  Pravastatin (Pravachol). 6  Rosuvastatin (Crestor). 7  Simvastatin (Zocor).
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- Pimentel concluded that, of the various statins examined, lovastatin lactone was the only effective inhibitor of methane production in the stool homogenates, significantly inhibiting methane levels by -65% compared to the control stool.
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Principles of Biochemistry/Biosynthesis of lipids Description. Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis.escription. Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis.