is dose response effective
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Effective dose (pharmacology) An effective dose (ED) in pharmacology is the dose or amount of drug that produces a therapeutic response or desired effect in some fraction of the subjects taking it.D50 [edit]. The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). It is also sometimes abbreviated as the ED50, meaning effective dose, for 50% of people receiving the drug.
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Techniques of opioid administration The key to making the traditional methods of opioid administration more effective is to individualize treatment regimens for patients by titrating the drug dose and frequency to suit the patient. The principle is to titrate the dose against effect (pain relief) and minimize adverse effects.
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Clinic to study long-term effectiveness of MMR vaccine ​​​​​​​​A $440,000 federal grant will support Marshfield Clinic researchers’ study of long-term effectiveness of a third dose of Measles, Mumps and Rubella (MMR) vaccine, as scientists work to better protect against mumps.Researchers will work to determine the long-term immune response to a third dose.ost people diagnosed with mumps in these outbreaks had received two previous doses of MMR vaccine. As a result, the Centers for Disease Control and Prevention (CDC) is interested in studying the long-term response to a third dose to help inform policy should future outbreaks occur.
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- Objective evidence of this hypersensitivity relies on challenge experiments. A shift in the cough dose response curve with a lower threshold in URTI, has been demonstrated to capsaicin challenge [9, 10]. Recovery of the cough reflex to a more normal level is seen as the infection abates.
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Equivalent dose Equivalent dose H T is calculated using the mean absorbed dose deposited in body tissue or organ T, multiplied by the radiation weighting factor W R which is dependent on the type and energy of the radiation R.
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Unit2/Obj1 Radiation Responses An early effect is a radiation response in humans within a few days to months due to a substantial dose. These early effects are described as deterministic and they exhibit increasing severity with increasing radiation dose, also there is usually a dose threshold. Genetic effects are late effects.
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Allergy Shots (Immunotherapy) Allergy shots decrease sensitivity to allergens and often leads to lasting relief of allergy symptoms even after treatment is stopped. This makes it a cost-effective, beneficial treatment approach for many people.
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- Rectal dose constraints for intensity modulated radiation therapy of the prostate. Swanson GP(1), Stathakis S. Author information: (1)Department of Radiation Oncology, University of Texas Health Science Center, San Antonio, TX 78229, USA.he most disabling toxicity in prostate cancer radiotherapy is rectal. We evaluated the current status of conformal radiation and late rectal toxicity with the goal of determining whether reasonable rectal dose and volume constraints can be determined.
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Reference Dose (RfD): Description and Use in Health Risk Assessments The U.S. EPA established the Reference Dose (RfD) Work Group to address these concerns. In preparing this report, the RfD Work Group has drawn on traditional report on risk assessment (NRC, 1983), to more fully articulate the use of noncancer, nonmutagenic experimental data in reaching regulatory decisions about the significance of exposures to chemicals.
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- There were no hospital readmissions in either treatment group, and there was no difference between the groups with regard to length of hospital stay. The authors conclude that high-dosage inhaled corticosteroids are as effective as systemic corticosteroids in the treatment of patients with severe asthma. The use of inhaled corticosteroids can reduce the adverse effects of systemic corticosteroids.
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Using Pharmacodynamic and Pharmacokinetic Concepts to Optimize Treatment of Infectious Diseases For agents with concentration-dependent killing, such as aminoglycosides and fluoroquinolones, the best responses occur when the concentrations are at least 10 times above the MIC for their target organism(s) at the site of infection.
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International Journal of Radiation Oncology*Biology*Physics In this study we demonstrate a safe method of dose escalation to a mean dose of 50 Gy in 5 fractions for patients with higher-risk disease, by using a high-dose avoidance zone (around the urethra, bladder, and rectum).
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Immune Response Immunotherapy treatment is designed to support the immune system's ability to adapt its attack over time3,5-8. 1  Each patient's population of tumor cells mutates over time, which may result in resistance to traditional anticancer therapies3.
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- More than 3/4 of the participating physicians noted a good or a very good efficacy, and 98.7% noted a good or a very good tolerance. Authors conclude that high-dose Hawthorn therapy is an efficient, well-tolerated and easily regulated therapeutic alternative for patients suffering from cardiac insufficiency stage.
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- Almost 20 years ago, Emami et al. presented a comprehensive set of dose tolerance limits for normal tissue organs to therapeutic radiation, which has proven essential to the field of radiation oncology.ur Phase II effort is to analyze these dose tolerance limits, consolidate them into expert-opinion “high-risk” and “low-risk” categories, and provide dose tolerance limits in a unified framework from one to five fractions.
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Allergen Immunotherapy Allergen immunotherapy is safe and has been shown to be effective in the treatment of stinging-insect hypersensitivity, allergic rhinitis or conjunctivitis, and allergic asthma.
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- Saving time is important to prevent a pathogen from establishing itself and infecting more cells in the body. An effective vaccine will optimally activate both the innate and adaptive response. An immunogen is used to activate the adaptive immune response so that specific memory cells are generated.
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Effective dose (pharmacology) For the geodetic datum ED50, see ED50. An effective dose (ED) in pharmacology is the dose or amount of drug that produces a therapeutic response or desired effect in some fraction of the subjects taking it. It has been stated that any substance can be toxic at a high enough dose.
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Michelangelo Buonarroti Their rough and unfinished states may be partly intentional, and they are certainly more emotionally expressive because of their roughness. Michelangelo began both the Palestrina Pieta and the Rondanini (or Milan) Pieta in 1556, when he was already in his eighties.
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Sievert Equivalent dose to an organ or tissue is the organ dose corrected by a radiation weighting factor that takes account of the relative biological effectiveness of the incident radiation in producing stochastic effects. This correction factor is numeri-cally 1 for X rays.he concept of air kerma, a measurable quantity outside the human body has been recommended by the IAEA and ICRU (International Commission on Radiation Units and Measurements). From air kerma, one estimates the entrance air kerma on patient or other quantities such as CTDI w or CTDI v.
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- This site is published by BabyCenter, L.L.C., which is responsible for its contents as further described and qualified in the Terms of Use.
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- Adverse reactions are no more common than for other vaccines routinely given to babies and children. The Hib vaccine is not a live vaccine and cannot cause even a very mild form of the disease. The Hib vaccine is very effective, but no vaccine is 100% effective. Although the risk of getting Group C meningococcal disease is not high, it outweighs any small risk from the vaccine. 2  The vaccine is not 'live' and cannot cause even a mild form of meningitis or septicaemia. 3  There are no new ingredients in the vaccine.
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- Although vaccines have very high effectiveness rates, they are not completely effective for 100% of the people who receive them.
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- Pitts T, Bolser D, Rosenbek J, Troche M, Okun MS, Sapienza C. Brief research report: the feasibility of expiratory resistive loading using the threshold inspiratory muscle training device. A randomized controlled trial assessing the effect of 4 wk EMST on patients with PD was conducted by Troche et al.
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- The most important factor in the effectiveness of chemical weapons is the efficiency of its delivery, or dissemination, to a target. The most common techniques include munitions (such as bombs, projectiles, warheads) that allow dissemination at a distance and spray tanks which disseminate from low-flying aircraft.
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- At 10 years, the absolute survival rate was significantly greater for the group receiving adjuvant therapy (49%) than for the control group (39%). Adjuvant goserelin boosted prostate ca survival The new research indicates routine use of adjuvant therapy might save an estimated 5,000 U. Drugs give slight edge in breast cancer a biotechnology company developing adjuvanted vaccines and immunotherapeutics for infectious diseases and cancer, today announced positive results from a Phase 1 clinical trial of its lead compound, JVRS-100, as an adjuvant for influenza vaccines.