what is monogenic obesity
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Monogenic obesity Monogenic obesity: Introduction. Monogenic obesity: Obesity caused by a mutation in a single gene. So far, four different genetic mutations have been linked to this condition. More detailed information about the symptoms, causes, and treatments of Monogenic obesity is available below.eview possible medical complications related to Monogenic obesity: 1  Increased risk of cardiovascular disease. 2  Increased risk of cancer. 3  Increased risk of type 2 diabetes. 4  more complications...».
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Classification of obesity Classification of obesity. Obesity is a medical condition in which excess body fat has accumulated to the extent that it has an adverse effect on health. Relative weight and body mass index (BMI) are nearly identical and are reasonable estimates of body fatness as measured by percentage body fat.
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From monogenic to polygenic obesity: recent advances The heritability of obesity and body weight in general is high. A small number of confirmed monogenic forms of obesity—the respective mutations are sufficient by themselves to cause the condition in food abundant societies—have been identified by molecular genetic studies.he brain derived neurotrophic factor (BDNF) is involved in weight regulation downstream of the MC4R. Mutations in single genes of the leptinergic–melanocortinergic pathway have been shown to have a monogenic effect on the development of obesity.
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Obesity â is it a genetic disorder? Several mutations in human genes with homology to obesity-causing genes in mice or in genes involved in the same metabolic pathways have been identified. In such cases, obesity is the dominant feature and is largely independent of environmental factors.
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Gene Therapy and Monogenic Disorders Monogenetic Disorders A plethora of human diseases have been identified as having a genetic origin and whilst some of these arise as result of mutations occurring at multiple locations, a substantial proportion manifest as result of a single gene mutation, synonymous with the common term of “monogenic disorders” [1].
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Obesity Definition and Etiology. Obesity has become an important public health problem in industrialized countries throughout the world. The body mass index (BMI = weight (in kg/height2 [in m2]) is the primary measurement used to categorize obese patients (Table 1).
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Definitions &Translations Catherine Falconer: Type 2 diabetes is commonly associated with an obesogenic lifestyle, including low levels of physical activity. For some people with type 2 diabetes, mobility issues may prevent them from achieving sufficient physical activity, but for others it may be a result of behavior and environmental factors. Leigh Vanderloo:
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- Obesity is excess fat due to eating more calories than used. It is usually defined by having a body mass index (BMI) of 25 or higher.
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definitions - Obesityreport a problem Obesity is most commonly caused by a combination of excessive food intake, lack of physical activity, and genetic susceptibility. A few cases are caused primarily by genes, endocrine disorders, medications, or mental illness.
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Obesity and overweight What are overweight and obesity? Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. Body mass index (BMI) is a simple index of weight-for-height that is commonly used to classify overweight and obesity in adults. It is defined as a person's weight in kilograms divided by the square of his height in meters (kg/m2).
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- Obesity is a medical condition in which excess body fat has accumulated to the extent that it has a negative effect on health.
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Obesity Overweight or obesity occurs when, over time, the body takes in more calories than it burns. However, some people do gain weight more easily than others. Another possible cause of obesity is a hormone imbalance, as in hypothyroidism (underactive thyroid gland) or Cushing’s syndrome. This is rare, though.
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- Clinics for Obesity. Obesity: Having excess body fat that is considered unhealthy for a person’s stature is called obesity and increases the risk of diabetes, heart disease, stroke, arthritis, and.. obesity overweight excess-body-fat effects of obesity obese. Bariatric Surgery & Medical Weight Loss in Palo Alto.
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What is Obesity? Obesity is a condition where a person has accumulated so much body fat that it might have a negative effect on their health. If a person's bodyweight is at least 20% higher than it should be, he or she is considered obese. If your Body Mass Index (BMI) is between 25 and 29.9 you are considered overweight. If your BMI is 30 or over you are considered obese.
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Obesity and Cancer Obesity is a condition in which a person has an abnormally high and unhealthy proportion of body fat. To measure obesity, researchers commonly use a scale known as the body mass index (BMI). BMI is calculated by dividing a person’s weight (in kilograms) by their height (in meters) squared.BMI provides a more accurate measure of obesity or being overweight than weight alone.mong men, a higher BMI is strongly associated with increased risk of colorectal cancer. The distribution of body fat appears to be an important factor, with abdominal obesity, which can be measured by waist circumference, showing the strongest association with colon cancer risk.
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- Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems.
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obesity n a type of obesity characterized by the enlarged size of fat cells within the body. An increased distribution of weight in the waist region is a typical indicator of this type of obesity. It is associated with an increased risk of hypertension, diabetes, and other metabolic disorders.
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How Much Does it Cost to Fill a Pool with Water? According to the Sierra Club, filling up a small pool in Texas will cost you about $100. Keep in mind that due to evaporation, you may have to top off your pool with water every so often.
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Assisted Living Costs Review the Average Costs of Assisted Living by State Assisted Living Costs by State. The Genworth 2015 Cost of Care Survey is the most comprehensive study of its kind. Genworth Financial surveyed approximatey 15% of assisted living communities. The monthly cost is for a one-bedroom unit in an assisted living facility.he costs of assisted living care depend on the level of service a resident requires. The 2010 CDC National Survey of Residential Care Facilities provides some treasured insights into the costs of assisted living, but also how facilities charge residents.
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Monogenic Diabetes Monogenic diabetes appears in several forms and most often affects young people. In most forms of the disease, the body is less able to make insulin, a hormone that helps the body use glucose (sugar) for energy. Rarely, the problem is severe insulin resistance, a condition in which the body cannot use insulin properly.A correct diagnosis can help people get the right treatment.n most forms of the disease, the body is less able to make insulin, a hormone that helps the body use glucose (sugar) for energy. Rarely, the problem is severe insulin resistance, a condition in which the body cannot use insulin properly. A correct diagnosis can help people get the right treatment.
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- Obesity: The Problem. Prevalence. Obesity is a disease in which fat accumulates in the body, to the point where has an adverse effect on health. By common practice, obesity is measured in the Western world by a Body Mass Index (BMI) of 30 kg/m2 or greater. The prevalence of overweight and obesity in Australia has been steadily increasing over the past 30 years.
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Medical Causes of Obesity Medical Causes of Obesity Obesity is usually the result of overeating, but in a small percentage of people excess weight gain is a symptom of another disease. Medical causes of obesity can include: Hypothyroidism. This is a condition where the thyroid gland, located in the neck, produces too little thyroid hormone. Thyroid hormone regulates our metabolism. So too little hormone slows the metabolism and often causes weight gain.
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Hypertrophic obesity what is it? Hypertrophic obesity is excessive weight gain in adulthood. And, a further explanation. Hypertrophic is when the fat cells get bigger. This is as opposed to Hyperplastic obesity, which is the gaining of fat cells. The latter only occurs during childhood, or if the person gains a lot of weight fast.
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Monogenic obesity The heterogeneity of human morbid obesity is becoming increasingly apparent with a growing number of monogenic disorders leading to profound dysregulation of body fat mass being identified.Congenital leptin deficiency is associated with extreme hyperphagia and hypogonadotropic hypogonadism.he heterogeneity of human morbid obesity is becoming increasingly apparent with a growing number of monogenic disorders leading to profound dysregulation of body fat mass being identified.
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Monogenic Diabetes (Neonatal Diabetes Mellitus & MODY) In most cases of monogenic diabetes, the gene mutation is inherited; in the remaining cases the gene mutation develops spontaneously. Most mutations in monogenic diabetes reduce the body's ability to produce insulin, a protein produced in the pancreas that helps the body use glucose for energy.