is prolia a bisphosphonate
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Denosumab (aka Prolia, Xgeva) â Even Worse than the Bisphosphonates? Like the bisphosphonates, denosumab (trade names Prolia, Xgeva) also prevents osteoclasts from removing old, damaged or worn out bone. It just does so via a different action than the bisphosphonates — an action that may turn out to have even more harmful side-effects.
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FDA OKs Prolia for High-Risk Osteoporosis WebMD News Archive. June 2, 2010 -- The FDA has approved twice-a-year Prolia (denosumab) injections to treat osteoporosis in patients at high risk of fracture. Prolia is a so-called monoclonal antibody -- a fully human, lab-produced antibody that inactivates the body's bone-breakdown mechanism.
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Biologics Feature Prolia is indicated for the treatment of postmenopausal women with osteoporosis at high risk for fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients who have. failed or are intolerant to other available osteoporosis therapy.
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Prolia Prolia is injected under the skin of your stomach, upper thigh, or upper arm. A healthcare provider will give you this injection. Prolia is usually given once every 6 months. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. Take only the amount of calcium and vitamin D that your doctor has prescribed.
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Prolia Tell your doctor if you: 1  Are taking a medicine called Prolia® (denosumab) because it contains the same medicine as XGEVA®. 2  Have symptoms of low blood calcium such as muscle stiffness or cramps. 3  Have symptoms of severe jaw bone problems such as pain or numbness.  Have ongoing pain or slow healing after dental surgery.
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What Are Bisphosphonates? Bisphosphonates are very effective in the treatment and management of cancer-related conditions, as well as in the treatment of osteoporosis and osteopenia. The use of bisphosphonates is expected to increase two and a half fold by the year 2011, as compared with the year 2004.
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- Bisphosphonates and cancer. Bisphosphonates are drugs that slow down or prevent bone damage. They also lower calcium levels. How cancer can affect the bones. Some cancers can cause bone pain and weakness. These are most often cancers that have started in another part of the body and have spread to the bone (secondary bone cancer).
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Prolia Prolia ® is indicated for treatment to increase bone mass in men with osteoporosis at high risk for fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients who have failed or are intolerant to other available osteoporosis therapy.
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Prolia Comment from: champ, 55-64 on Treatment for 6 months - 1 year (Patient) Published: June 22. I got my first injection of Prolia in September of 2010 without much explanation from my doctor except that it was the next drug we could try to help with my osteoporosis.
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- DEFINITION of 'Cafeteria Plan'. An employee benefit plan that allows staff to choose from a variety of benefits to formulate a plan that best suits their needs. Cafeteria plan options may include health and accident insurance, cash benefits, tax advantages and/or retirement plan contributions.
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- Locations farthest away from Indianapolis. 1  Amsterdam Island, French Southern Territories, 11,555 mi. 2  Bunbury, Western Australia, Australia, 11,154 mi. 3  Mandurah, Western Australia, Australia, 11,124 mi.  Port-aux-Francais, French Southern Territories, 11,105 1  mi. Perth, Western Australia, Australia, 11,098  mi.
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- “The way that denosumab (Prolia) works is that it’s a fully human monoclonal antibody to RANK ligand. So when you give somebody a shot in the arm of this drug every six months, they get a six-month period during which the antibody is active, after which it stops working.
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- Prolia® is the first and only prescription therapy for postmenopausal osteoporosis treatment given as a shot 2 times a year in your doctor's office, taken along with calcium and vitamin D. To understand how Prolia® works, it's helpful to understand how postmenopausal osteoporosis affects your bones.
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Denosumab (Prolia and Xgeva) Denosumab (Prolia and Xgeva) Treatment to increase bone mass in men at high-risk for fracture (low bone mineral density (T score at the lumbar spine, total hip, or femoral neck of less than -1.0) at baseline or a history of an osteoporotic fracture) receiving androgen deprivation therapy for prostate cancer.
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Prolia Each 1 mL single-use prefilled syringe of Prolia contains 60 mg denosumab (60 mg/mL solution), 4.7% sorbitol, 17 mM acetate, 0.01% polysorbate 20, Water for Injection (USP), and sodium hydroxide to a pH of 5.2.
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Prolia In these studies, taking Prolia (along with calcium and vitamin D) reduced the risk of vertebral fractures (broken spinal bones) by 68 percent, compared to women who took just calcium and vitamin D. Prolia also reduced the risk of hip fractures by 40 percent.
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Prolia It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. These are not all the possible side effects of Prolia®.
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Prolia Hypocalcemia: Hypocalcemia may worsen with the use of Prolia®, especially in patients with severe renal impairment. In patients predisposed to hypocalcemia and disturbances of mineral metabolism, clinical monitoring of calcium and mineral levels is highly recommended within 14 days of Prolia® injection. Adequately supplement all patients with calcium and vitamin D.
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Prolia Of the total number of patients in clinical studies of Prolia, 9943 patients (76%) were ≥ 65 years old, while 3576 (27%) were ≥ 75 years old. Of the patients in the osteoporosis study in men, 133 patients (55%) were ≥ 65 years old, while 39 patients (16%) were ≥ 75 years old.
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Prolia 1 Prolia should be administered by a healthcare professional (2.1) 2  Administer 60 mg every 6 months as a subcutaneous injection in the upper arm, upper thigh, or abdomen (2.1)  Instruct patients to take calcium 1000 mg daily and at least 400 IU vitamin D daily (2.1)
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Prolia NUTRITION FACTS. Important Safety Information Close. Do not take Prolia® (denosumab) if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.
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F.D.A. Approves a Bone Drug for Cancer Patients It is sold for that purpose under the name Prolia. Sales so far have been slow. But the use for cancer patients might be more lucrative for Amgen because cancer patients would use 12 times as much of the drug a year than osteoporosis patients do. Sales could easily surpass $1 billion a year, some analysts estimate.
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Denosumab In June 2010, denosumab was approved by the U.S. Food and Drug Administration (FDA) for use in postmenopausal women with risk of osteoporosis under the trade name Prolia, and in November 2010, as Xgeva, for the prevention of skeleton-related events in patients with bone metastases from solid tumors.n 17 December 2009, the Committee for Medicinal Products for Human Use (CHMP) issued a Positive Opinion for denosumab for the treatment of postmenopausal osteoporosis in women and for the treatment of bone loss in men with hormone ablation therapy for prostate cancer.
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- Prolia® is the first and only prescription therapy for postmenopausal osteoporosis treatment given as a shot 2 times a year in your doctor's office, taken along with calcium and vitamin D. Learn More. To understand how Prolia® works, it's helpful to understand how postmenopausal osteoporosis affects your bones.
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Xgeva You may need to have a dental exam before you begin treatment with Prolia. Follow your doctor's instructions. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving denosumab. You may need to stop using the medicine for a short time.
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- 1 Denosumab (Prolia). It's used to treat people who are at high risk for bone fractures related to decreased bone density.  Teriparatide (Forteo). It's used for the treatment of men and postmenopausal women who have severe osteoporosis and who are at high risk for bone fracture.