medical definition tissue plasminogen activator
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Tissue plasminogen activator View/Edit Mouse. Tissue plasminogen activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease (EC 3.4.21.68) found on endothelial cells, the cells that line the blood vessels.
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Matrix metalloproteinase (MMP)-9: A proximal biomarker for cardiac remodeling and a distal biomarker for inflammation MMP-9 roles in inflammation: neutrophils, macrophages, and lymphocytes are cell sources of MMP-9 MMP-9 is secreted by neutrophils early post-MI, and by macrophages, lymphocytes, and fibroblasts at later phases post-MI .
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Coagulation The tissue factor (extrinsic) pathway is initiated by release of tissue factor (a specific cellular lipoprotein), and can be measured by the prothrombin time (PT) test. PT results are often reported as ratio (INR value) to monitor dosing of oral anticoagulants such as warfarin.he main role of the tissue factor pathway is to generate a thrombin burst, a process by which thrombin, the most important constituent of the coagulation cascade in terms of its feedback activation roles, is released very rapidly.
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Definitions &Translations Thrombopoietin. Thrombopoietin also known as megakaryocyte growth and development factor is a protein that in humans is encoded by the THPO gene. Thrombopoietin is a glycoprotein hormone produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that fragment into large numbers of platelets.
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- To display the IP routing table on computers running Windows Server 2003 operating systems, you can type route print at a command prompt.
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pyrogen endogenous pyrogen a low-molecular-weight protein that is produced by phagocytic leukocytes in response to stimulation by exogenous pyrogens and released into the circulation; it induces fever by acting on the preoptic area of the hypothalamus to raise the set-point of the hypothalamic thermostat.ndogenous pyrogen a low-molecular-weight protein that is produced by phagocytic leukocytes in response to stimulation by exogenous pyrogens and released into the circulation; it induces fever by acting on the preoptic area of the hypothalamus to raise the set-point of the hypothalamic thermostat.
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chapter 8 part 2. medical terminology: cardiovascular system thrombolysis. destruction of a blood clot using anticlotting agents called clot busters, such as tissue plasminogen activator.it can restore blood flow to tissue before serious irreversible damage occurs. however, many of these agents also pose the risk of hemorrhage.
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- 1 A second amino acid domain that does not mediate self-assembly in isolated form, wherein the second amino acid domain comprises a biologically active motif. 2  In some aspects, the dental tissue is periodontal ligament tissue and the self-assembling peptide is administered to the peridontium.atents. The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for tissue regeneration, increasing the production of extracellular matrix proteins, and methods of treatment...
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Fibrinolysis Alpha 2-antiplasmin and alpha 2-macroglobulin inactivate plasmin. Plasmin activity is also reduced by thrombin-activatable fibrinolysis inhibitor (TAFI), which modifies fibrin to make it more resistant to the tPA-mediated plasminogen.
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plasminogen activator inhibitor plasminogen activator inhibitor. Definition: plasma protein active in thrombus turnover; along with tissue plasminogen activator (tPA) and lipoprotein Lp(a), was found to be increased in patients with angiographically verified coronary artery disease.
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TFPI tissue factor pathway inhibitor [ (human)] The expression of tissue factor and tissue factor pathway inhibitor in prostate cancer cells themselves is unlikely to be the source of hypercoagulability in patients, but might precipitate chains of events that would produce such an effect.
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- Int J Cancer. 2005. Philinopside A is a novel sulfated saponin isolated from the sea cucumber, Pentacta quadrangulari. The effects of philinopside A on angiogenesis and tumor growth were assessed in a series of models in vitro and in vivo.
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- Endogenous antigen. Definition. noun. Antigen that is produced from within the cell as part of normal cell metabolism or when the cell is infected by bacteria or viruses.Supplement. For instance, when the virus infects the cell, antigens are formed and presented on the surface of the cell.ntigen that is produced from within the cell as part of normal cell metabolism or when the cell is infected by bacteria or viruses. Supplement. For instance, when the virus infects the cell, antigens are formed and presented on the surface of the cell.
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- Organism descriptor(s) : Asparagus densiflorus Descriptor(s) : 2,4-D, abscisic acid, alpha-naphthaleneacetic acid, benzyladenine, callus, enzyme activity, enzymes, IAA, in vitro culture, in vitro regeneration, kinetin, peroxidase, plant growth regulators, plant tissues, somatic embryogenesis, somatic embryos, techniques, tissue culture
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- Also used to lessen side effects that may be caused by some cancer treatments. Also known as immunotherapy, biotherapy, or biological response modifier (BRM) therapy. biopsy (BY-ahp-see): The removal of cells or tissues for examination under a microscope.
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- ABSTRACT. Metaplasia is a reversible reprogramming of stem cells of the epithelium. Usually, squamous metaplasia is observed in the endocervix. However, less frequently, tubal metaplasia may develop, replacing nonciliated columnar cells by ciliated columnar cells, similar to fallopian tube epithelium.
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- VA CLASSIFICATION. Primary: BL115. Commonly used brand name(s): TNKase. TNKTNK-tPATNK-tissue plasminogen activator Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s).
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CD31 Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome 17.PECAM-1 plays a key role in removing aged neutrophils from the body.D31 is also expressed in certain tumors, including epithelioid hemangioendothelioma, epithelioid sarcoma-like hemangioendothelioma, other vascular tumors, histiocytic malignancies, and plasmacytomas.
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PAF platelet-activating factor (PAF) a substance released by basophils and mast cells in immediate hypersensitivity reactions, and by macrophages and neutrophils in other inflammatory reactions; it leads to bronchoconstriction, platelet aggregation, and release of vasoactive substances from platelets.
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- This acknowledgment indicates that the facility's time to thrombolytic therapy was within 60 minutes in 75 percent or more of acute ischemic stroke patients treated with the clot-buster tissue plasminogen activator, or tPA, (the only drug approved by the U.
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Tissue engineering 1 Allogeneic cells come from the body of a donor of the same species. 2  While there are some ethical constraints to the use of human cells for in vitro studies, the employment of dermal fibroblasts from human foreskin has been demonstrated to be immunologically safe and thus a viable choice for tissue engineering of skin.ach 'layer' of the microfluidic device (cells seeded in ECM, a hydrogel sheath, and finally a calcium chloride solution). The seeded cells culture within the hydrogel sheath for several days, and then the sheath is removed with viable cell fibers.
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tissue plasminogen activator A gene on chromosome 8p12 that encodes tissue plasminogen activator, which converts inactive plasminogen to plasmin by hydrolysing a single Arg-Val bond in plasminogen, thereby playing a key role in tissue remodelling, degradation, cell migration and other cellular events. PLAT directly facilitates neuronal migration.
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Activase DRUG DESCRIPTION. Activase is a tissue plasminogen activator produced by recombinant DNA technology. It is a sterile, purified glycoprotein of 527 amino acids. It is synthesized using the complementary DNA (cDNA) for natural human tissue-type plasminogen activator obtained from a human melanoma cell line.
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- Newell said, The objective of this study was to evaluate the safety and efficacy of a novel therapy which combines ultrasound with recombinant tissue plasminogen activator (rt-PA) delivered through a microcatheter directly into spontaneous IVH or ICH in humans, to facilitate evacuation of the hemorrhage.
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Blood clot dissolving agent All these drugs digest clots by increasing the amount of plasmin (plasmin dissolves clots) in the blood. To produce plasmin, the substance plasminogen must first be activated. Plasminogen is converted into plasmin by certain enzymes known as plasminogen activators. Streptokinase has been used since about 1960.
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tissue plasminogen activator tissue plasminogen activator (TPA), a clot-dissolving substance produced naturally by cells in the walls of blood vessels. It is also manufactured synthetically by genetic engineering techniques.issue plasminogen activator. see plasminogen activator.