what causes low alkaline phosphatase
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Alkaline Phosphatase Low Malnutrition is the most common cause of low alkaline phosphatase. In particular, inadequate consumption of vitamin B6, folic acid, vitamin C, zinc, and magnesium are the most common nutritional causes, along with excess consumption of vitamin D.
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- Significance of Low Alkaline Phosphates. The significance and causes of low alkaline phosphatase may indicate certain conditions such as malnutrition, celiac disease, hypothyroidism, magnesium and zinc deficiency, anemia and menopause.
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Useful For Alkaline phosphatase (ALP) is present in a number of tissues including liver, bone, intestine, and placenta. Serum ALP is of interest in the diagnosis of 2 main groups of conditions-hepatobiliary disease and bone disease associated with increased osteoblastic activity.
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What Low Alkaline Phosphatase Levels Mean for You Osteoblasts require an alkaline environment to lay down bone and alkaline phosphatase is involved in this process. The enzyme is produced by the mucosal cells that line the bile system of the liver. If there is disease in the liver, bile ducts or gallbladder, alkaline phosphatase is released to the blood stream causing its level to rise.
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Milk-alkali syndrome If untreated, milk-alkali syndrome may lead to kidney failure or death. It was most common in the early 20th century, but since the 1990s, there has been an increase in the number of cases reported, linked to the increased use of calcium supplements to address or prevent osteoporosis.
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- While alkaline phosphatase may not necessarily cause harm to the body itself, elevated levels are associated with cancer, bone, liver, and kidney diseases (R). High liver alkaline phosphatase levels are associated with bile duct obstruction and liver cancer. The presence of liver alkaline phosphatase in patients may indicate the presence of a tumor in the bile duct (R).
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What Are the Symptoms and Treatments for High Alkaline Phosphatase Levels? Quick Answer. Because an elevated alkaline phosphatase, or ALP, level can be associated with different medical conditions like rickets, cirrhosis, hepatitis, bone cancer, Paget's disease, hyperparathyroidism and a deficiency in vitamin D, symptoms and treatment options are different and dependent on the specific cause, as noted by WebMD.
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Bloodwork- Alkaline Phosphatase Answer : There are dogs who have elevated alkaline phosphatase (ALKP) levels for a long time prior to any other clinical signs of hyperadrenocorticism. Other dogs have hyperplasia of the liver for no apparent reason and have high ALKP levels that do not lead to clinical disease.nswer : I think that the best way to approach your questions is to explain the differences between rises in ALT and alkaline phosphatase and give you a list of causes for both conditions and then work from there. ALT is short for alanine transferase. This is an enzyme that is present in the cells in the liver.
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Alkaline Phosphatase  [en EspaÃ±ol] If the ALP level is high, more tests may be done to find the cause. The amounts of different types of ALP in the blood may be measured and used to determine whether a high level is from the liver or bones. This is called an alkaline phosphatase isoenzymes test.
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- When AP is elevated in mature pets, most causes are associated with a primary or secondary liver problem that prevents the normal flow of bile. In cats, the two most common causes of elevated alkaline phosphatase are cholangiohepatitis and hepatic lipidosis (HL). In HL, blood bilirubin levels are usually quite high as well. Bile duct obstruction (gallstones) – particularly when GGT enzyme is elevated equally or greater - is sometimes the cause.
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Liver Function Tests Alkaline Phosphatase (ALP) Test. Alkaline phosphatase (ALP) is an enzyme found in your bones, bile ducts, and liver. An ALP test is typically ordered in combination with several other tests. High levels of ALP may indicate liver damage, blockage of the bile ducts, or a bone disease.
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Elevated Alkaline Phosphatase The laboratory test for elevated levels of alkaline phosphatase (ALP) is a diagnostic for detection of liver and bone disorders. The levels of this enzyme can increase due to physiological as well as pathological causes.
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Alkaline phosphatase Alkaline phosphatase (ALP, ALKP, ALPase, Alk Phos) (EC 3.1.3.1) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is called dephosphorylation.ormal ALP levels in adults are approximately 20 to 140 IU /L, though levels are significantly higher in children and pregnant women. Blood tests should always be interpreted using the reference range from the laboratory that performed the test. High ALP levels can occur if the bile ducts are obstructed.
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What Are the Causes of low Alkaline Phosphatase? Alkaline phosphatase can also indicate a liver dysfunction or severe liver failure, which can be caused by cirrhosis (the condition in which the cells are destroyed by the liver), or hepatitis (liver inflammation).
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ALP (Alkaline Phosphatase Level) Test An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream.The test requires a simple blood draw and is often a routine part of other blood tests. Abnormal levels of ALP in your blood most often indicate a problem with your liver and/or bones.lkaline phosphatase is an enzyme found in your bloodstream. ALP helps break down proteins in the body and exists in different forms, depending on where it originates. It is mostly produced in your liver, but some is also made in your bones, intestines, and kidneys.
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Alkaline Phosphatase Low Low alkaline phosphatase is one of the early indicators of this deficiency, which can lead to more serious symptoms later on if it continues (eventually being fatal). Hypothyroidism is a condition in which the production of hormones by the thyroid glad is below normal. This condition can also result in low ALP levels.
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- Alkaline Phosphatase. Alkaline phosphatase (ALP) is an enzyme that is mostly synthesized in the liver and bone. Altered levels of alkaline phosphatase in the blood can be indicative of certain specific disease pathologies.
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- When the alkaline phosphatase (ALP) test result is high, you may need to have the ALP isoenzyme test. This test will help determine what part of the body is causing higher ALP levels. It may also be done to check liver function and to see how medicines you take may affect your liver.
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Causes of a High Level of Alkaline Phosphatase in Blood Diseases of the skeletal system can raise levels of alkaline phosphatase in the blood. Photo Credit xray of a broken leg bone image by alma_sacra from Fotolia.com. Alkaline phosphatase is an enzyme found throughout the body. However, it tends to be most concentrated in the liver, the bile ducts, bones and placenta.Diseases that damage and destroy the cells of these organs lead to the release of alkaline phosphatase into the blood, which raises the blood level of alkaline phosphatase.one also contains high levels of alkaline phosphatase. Any disease that damages bone can release alkaline phosphatase into the blood. Examples include primary bone cancer and metastatic bone cancers, a broken bone or osteoporosis.
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What Is a Normal Level of Alkaline Phosphatase? Alkaline phosphatase is an enzyme found in many organs, including the liver, bone, kidney, intestine and placenta. The highest concentration of alkaline phosphatase comes from the liver and bone. A routine blood test detects the total amount of alkaline phosphatase in the blood.ecause this test is not specific for liver or bone, other liver-or bone-specific blood tests are usually needed to help determine the source of an increased blood alkaline phosphatase level. Symptoms may also help determine the source. Otherwise, an alkaline phosphatase isoenzyme test can determine the source.
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Elevated Alkaline Phosphatase Elevated Alkaline Phosphatase. The laboratory test for elevated levels of alkaline phosphatase (ALP) is a diagnostic for detection of liver and bone disorders. The levels of this enzyme can increase due to physiological as well as pathological causes. Read on to find out all about ALP and the implications of increased ALP levels.
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- A decreased serum alkaline phosphatase may be due to: 1  Zinc deficiency. 2  Hypothyroidism. 3  Vitamin C deficiency/Scurvy. 4  Folic acid deficiency. 5  Excess Vitamin D intake. 6  Low phosphorus levels (hypophosphatasia) 7  Celiac disease. 8  Malnutrition with low protein assimilation (including low stomach acid production/hypochlorhydria).
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Elevated alkaline phosphatase Elevated alkaline phosphatase - Bone/skeletal. 1  Bone disease (bone ALP): Paget's disease, [4] osteosarcoma, bone metastases of prostatic cancer (High / very high ALP values) 2  Skeletal involvement of other primary diseases... 3  Other unlisted musculoskeletal conditions may also cause elevated alkaline phosphatase.
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- Medical Definition of Alkaline phosphatase. Alkaline phosphatase: An enzyme that liberates phosphate under alkaline conditions and is made in liver, bone, and other tissues. Alkaline phosphatase can be measured in a routine blood test. Abnormally high serum levels of alkaline phosphatase may indicate bone disease, liver disease, or bile duct obstruction.
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Understanding Lab Tests: Entire Lesson Explanation of test results: A high alk phos level does not reflect liver damage or inflammation. A high alk phos level occurs when there is a blockage of flow in the biliary tract or a buildup of pressure in the liver--often caused by a gallstone or scarring in the bile ducts.
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Elevated alkaline phosphatase Elevated alkaline phosphatase. Elevated alkaline phosphatase describes the situation where the levels of alkaline phosphatase (ALP) exceed the reference range. This group of enzymes has a low substrate specificity and catalyzes the hydrolysis of phosphate esters in a basic environment. The major function of alkaline phosphatase is transporting across cell membranes.