what does Hb SS mean sickle cell anemia
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- Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.
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- Sickle cell anemia, a common form of sickle cell disease, is caused by a particular mutation in the HBB gene. This mutation results in the production of an abnormal version of beta-globin called hemoglobin S or HbS.In this condition, hemoglobin S replaces both beta-globin subunits in hemoglobin.n adults, hemoglobin normally consists of four protein subunits: two subunits of beta-globin and two subunits of another protein called alpha-globin, which is produced from another gene called HBA.
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Overview Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin — the red, iron-rich compound that gives blood its red color. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body.ith one normal hemoglobin gene and one defective form of the gene, people with the sickle cell trait make both normal hemoglobin and sickle cell hemoglobin.
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- Sickle cell anemia is caused by an abnormal type of hemoglobin called hemoglobin S. Hemoglobin is a protein inside red blood cells that carries oxygen. 1  Hemoglobin S changes the red blood cells.
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STRUCTURE OF HAEMOGLOBIN AND HAEMOGLOBINOPATHIES The term sickle cell disease (SCD) describes a group of inherited red blood cell disorders. People with SCD have abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in their red blood cells. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body.eople who have SCD inherit two abnormal hemoglobin genes, one from each parent. In all forms of SCD, at least one of the two abnormal genes causes a person’s body to make hemoglobin S. When a person has two hemoglobin S genes, Hemoglobin SS, the disease is called sickle cell anemia.
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Sickle-cell disease Sickle-cell disease occurs when a person inherits two abnormal copies of the haemoglobin gene, one from each parent.Several subtypes exist, depending on the exact mutation in each haemoglobin gene. A person with a single abnormal copy does not experience symptoms and is said to have sickle-cell trait.he complications of sickle-cell disease can be prevented to a large extent with vaccination, preventive antibiotics, blood transfusion, and the drug hydroxyurea /hydroxycarbamide.
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- Sickle cell disease is an inherited blood disorder characterized by defective hemoglobin (a protein in red blood cells that carries oxygen to the tissues of the body).
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Sickle-cell disease sickle cell disease. Sickle cell anemia, a common form of sickle cell disease, is caused by a particular mutation in the HBB gene. This mutation results in the production of an abnormal version of beta-globin called hemoglobin S or HbS. In this condition, hemoglobin S replaces both beta-globin subunits in hemoglobin.
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STRUCTURE OF HAEMOGLOBIN AND HAEMOGLOBINOPATHIES The term sickle cell disease (SCD) describes a group of inherited red blood cell disorders. People with SCD have abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in their red blood cells.Hemoglobin is a protein in red blood cells that carries oxygen throughout the body.he term sickle cell disease (SCD) describes a group of inherited red blood cell disorders. People with SCD have abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in their red blood cells.
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- Sickle cell anemia: A genetic blood disease due to the presence of an abnormal form of hemoglobin, namely hemoglobin S. Hemoglobin is the molecule in red blood cells that transports oxygen from the lungs to the farthest areas of the body.Sickle cell anemia affects millions of people throughout the world.ickle cell anemia: A genetic blood disease due to the presence of an abnormal form of hemoglobin, namely hemoglobin S. Hemoglobin is the molecule in red blood cells that transports oxygen from the lungs to the farthest areas of the body.
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Overview Sickle cell anemia. Sickle cell anemia is an inherited form of anemia — a condition in which there aren't enough healthy red blood cells to carry adequate oxygen throughout your body. Normally, your red blood cells are flexible and round, moving easily through your blood vessels.n sickle cell anemia, the red blood cells become rigid and sticky and are shaped like sickles or crescent moons. These irregularly shaped cells can get stuck in small blood vessels, which can slow or block blood flow and oxygen to parts of the body. There's no cure for most people with sickle cell anemia.
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Life Expectancy of Someone With Sickle Cell Disease The life expectancy of a person with type HbSS sickle cell anemia is forty-two years for men and forty-eight years for women according to an article published in the New England Journal of Medicine.
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Sickle Cell Anemia Sickle cell disease is an inherited blood disorder in which the body produces abnormally shaped red blood cells. In sickle cell disease, the hemoglobin in red blood cells clumps together. This causes red blood cells to become stiff and C-shaped. These sickle cells block blood and oxygen flow in blood vessels.n sickle cell disease, the hemoglobin clumps together, causing red blood cells to become stiff and develop a C-shaped (“sickle”) form. These sickled red blood cells can block blood vessels, reducing blood flow in many parts of the body. This process results in tissue and organ damage.
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Names and Codes Hb SS-disease, also known as sickle cell anemia, is the most common disorder affecting hemoglobin. This condition is a form of sickle cell disease. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle (crescent) shape. Characteristic features of sickle cell anemia include anemia, repeated infections, and periodic episodes of pain and organ damage.
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sickle cell anemia sick·le cell anemia. A hereditary disease characterized by red blood cells that are sickle-shaped instead of round because of an abnormality in the hemoglobin, the protein that carries oxygen in the blood.
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Sickle cell disease Sickle cell disease is an inherited blood disorder characterized by defective hemoglobin (a protein in red blood cells that carries oxygen to the tissues of the body). Sickle cell disease involves the red blood cells, or hemoglobin, and their ability to carry oxygen.
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Hemoglobin SS disease (Hb SS) Anemia - sickle cell; Sickle cell anemia; Sickle cell disease. Definition. Sickle cell anemia is an inherited disease in which the red blood cells, normally disc-shaped, become crescent shaped. As a result, they function abnormally and cause small blood clots.
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- Sickle cell trait is identified as a person that carries the sickle cell defect, but they have a normal hemoglobin count in their blood that prevents them from showing any of the symptoms of sickle cell anemia. Sickle cell trait is becoming recognized as a serious condition that could be fatal if not properly addressed.
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Sickle-cell disease Sickle cell anemia, a common form of sickle cell disease, is caused by a particular mutation in the HBB gene. This mutation results in the production of an abnormal version of beta-globin called hemoglobin S or HbS.In this condition, hemoglobin S replaces both beta-globin subunits in hemoglobin.ore than 10 mutations in the HBB gene have been found to cause methemoglobinemia, beta-globin type, which is a condition that alters the hemoglobin within red blood cells.
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- sickle cell anemia a common form of sickle cell disease is caused by a particular mutation in the hbb gene this mutation results in the production of an abnormal version of beta globin called hemoglobin s or hbsin this condition hemoglobin s replaces both beta globin subunits in hemoglobineta globin is a component subunit of a larger protein called hemoglobin which is located inside red blood cells in adults hemoglobin normally consists of four protein subunits two subunits of beta globin and two subunits of another protein called alpha globin which is produced from another gene called hba
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Sickle-cell disease Sickle-cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle-cell anaemia (SCA). It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells.
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STRUCTURE OF HAEMOGLOBIN AND HAEMOGLOBINOPATHIES The term sickle cell disease (SCD) describes a group of inherited red blood cell disorders. People with SCD have abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in their red blood cells. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body.“Inherited” means that the disease is passed by genes from parents to their children.he term sickle cell disease (SCD) describes a group of inherited red blood cell disorders. People with SCD have abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in their red blood cells. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body.
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- Sickle cell disease (SCD) is a group of inherited disorders in which hemoglobin, the protein in red blood cells that carries oxygen, becomes hard and sticky and looks like a sickle. The symptoms of sickle cell disease include abdominal pain, bone pain, shortness of breath, delayed growth, fatigue, fever and chest pain.
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- 1. Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body.People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.. Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body.
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Sickle-cell disease Sickle-cell disease occurs when a person inherits two abnormal copies of the haemoglobin gene, one from each parent.Several subtypes exist, depending on the exact mutation in each haemoglobin gene. A person with a single abnormal copy does not experience symptoms and is said to have sickle-cell trait.he complications of sickle-cell disease can be prevented to a large extent with vaccination, preventive antibiotics, blood transfusion, and the drug hydroxyurea /hydroxycarbamide. A small proportion of patients require a transplant of bone marrow cells.
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Genetic Causes of Sickle Cell Anemia Genetic Mutation. The gene that can cause Sickle Cell Anemia is called HBB and is located in Chromosome 11. HBB helps in the creation of hemoglobin in the body. A normal adult's hemoglobin consists of two alpha chains and two beta chains; HBB codes for the beta chain and the protein it synthesizes is called beta globin.he trait that causes sickle cell anemia is recessive, which means that the disorder will only occur in a person who is homozygous recessive for the sickle cell trait. One way for this to occur is for a person to be an offspring of two parents who are heterozygous for the sickle cell trait.