what is filgotinib?
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- Description. Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
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fibril /fi·bril/ (fi´bril) a minute fiber or filament.fibril´larfib´rillary. collagen fibrils delicate fibrils of collagen in connective tissue, composed of molecules of tropocollagen aggregated in linear array. Type I collagen fibril (A); it is composed of unit fibrils, here shown negatively stained (B). The unit fibrils themselves comprise tropocollagen molecules in regular staggered arrays (C, D).
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Type 2 diabetes Type 2 diabetes is a lifelong (chronic) disease in which there is a high level of sugar (glucose) in the blood. Type 2 diabetes is the most common form of diabetes.
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- Sliding filament model of muscle contraction. A myofibril (also known as a muscle fibril) is a basic rod-like unit of a muscle cell. Muscles are composed of tubular cells called myocytes, known as muscle fibers in striated muscle, and these cells in turn contain many chains of myofibrils. Thin filaments consist primarily of the protein actin, coiled with nebulin filaments. 2  Actin, when polymerized into filaments, forms the ladder along which the myosin filaments climb to generate motion. 3  Thick filaments consist primarily of the protein myosin, held in place by titin filaments.
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- Fipronil is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride (GluCl) channels, resulting in central nervous system toxicity.ipronil is a slow acting poison. When used as bait, it allows the poisoned insect time to return to the colony or harborage. In cockroaches, the feces and carcass can contain sufficient residual pesticide to kill others in the same nesting site.
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Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor Î±âNeutralizing Agent Infliximab is a humanized antibody against tumor necrosis factor α (TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis. Approximately 147,000 patients throughout the world have received infliximab.
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pioglitazone Pioglitazone is an oral drug that reduces the amount of glucose (sugar) in the blood. It is in a class of anti-diabetic drugs called thiazolidinediones that are used in the treatment of type 2 diabetes. The other member in this class is rosiglitazone (Avandia).
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Fibrinogen Fibrinogen Activity Test. A fibrinogen activity test is also known as a factor I assay. It is used to determine the level of fibrinogen in your blood. Fibrinogen, or factor I, is a blood plasma protein that is made in the liver.It is one of 13 coagulation factors responsible for normal blood clotting.When you start to bleed, your body initiates a process called the coagulation cascade.ibrinogen Activity Test. A fibrinogen activity test is also known as a factor I assay. It is used to determine the level of fibrinogen in your blood. Fibrinogen, or factor I, is a blood plasma protein that is made in the liver. It is one of 13 coagulation factors responsible for normal blood clotting.
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Glycohemoglobin (HbA1c, A1c)  [en EspaÃ±ol] Glycohemoglobin (A1c) is a blood test that checks the amount of sugar (glucose) bound to the hemoglobin in the red blood cells. When hemoglobin and glucose bond, a coat of sugar forms on the hemoglobin. That coat gets thicker when there's more sugar in the blood.
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Neulasta Filgrastim is a human granculocyte colony stimulating factor (G-CSF), produced by recombinant DNA technology. Pegfilgrastim is a covalent conjugate of recombinant methionyl human G-CSF and monomethoxypolyethylene glycol.
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Is There New Hope for Fibromyalgia Sufferers from an Old Source? Is there a role for the generic Gabapentin in the fight against fibromyalgia? Gabapentin is the generic for Pfizer’s Neurontin and is a medication that’s used as an anticonvulsant and an analgesic. It was originally developed to treat epilepsy and is currently used to relieve neuropathic pain, shingles and restless leg syndrome. Now a new study a published in Pain Practice suggests that extended-release Gabapentin holds promise for treating fibromyalgia.
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Amprolium Download Filgotinib (GLPG0634) SDF. For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat.
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- By Lori Alma. Updated August 07, 2016. Cystic fibrosis (CF) is a chronic, life-shortening disease that occurs as a result of a genetic defect. The defective gene affects the body’s ability to transfer water and salt to and from cells that produce sweat, mucus, and digestive enzymes.
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Galapagos' JAK1 drug filgotinib aces phase IIb monotherapy trial The data keep filgotinib on track for a pivotal program, be it with or without Abbvie, which has to decide whether to stick with its own, earlier-stage JAK inhibitor ABT-494 or to shell out for a program that now has far less risk attached.
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Tysabri Tysabri® (natalizumab) is a prescription medication that belongs to a group of medicines called immunomodulators. It is approved to: Slow down the worsening of disability and reduce the number of relapses (times when symptoms flare up) in people with multiple sclerosis (MS)
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What is cicatricial pemphigoid? Cicatricial pemphigoid is an autoimmune disease that is characterised by blistering lesions on mucous membranes. It is also called benign mucous membrane pemphigoid or oral pemphigoid. Areas commonly involved are the oral mucosa (lining of the mouth) and conjunctiva (mucous membrane that coats the inner surface of the eyelids and the outer surface of the eye).
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Autonomic Dysfunction in Women With Fibromyalgia Fibromyalgia (FM) is an idiopathic disease characterized by widespread pain and a myriad of symptoms. Symptoms are diverse and include not only pain but also anxiety, depression, orthostatic intolerance, and cold intolerance.
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What is an Antibody?: Immunoglobulin What is an Antibody? | Immunoglobulin. Antibodies, also referred to as immunoglobulins, are glycoproteins naturally produced in response to invading foreign particles (antigens) such as microorganisms and viruses. As such, they play a critical role in the immune system’s defense against infection and disease.
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Cystic Fibrosis Cystic fibrosis (CF) is an inherited life-threatening disease that affects many organs. It causes changes in the electrolyte transport system causing cells to absorb too much sodium and water. CF is characterized by problems with the glands that make sweat and mucus.
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Filgotinib (GLPG0634) Filgotinib (GLPG0634) in DSS-treated mice demonstrates that inhibition of JAK1 is sufficient for achieving strong efficacy in pre-clinical mouse model, correlated to the inhibition of STAT3 phosphorylation in the inflamed colon.
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Leghemoglobin Leghemoglobin (also leghaemoglobin or legoglobin) is a nitrogen or oxygen carrier and hemoprotein found in the nitrogen-fixing root nodules of leguminous plants.
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Myofibril A myofibril (also known as a muscle fibril) is a basic rod-like unit of a muscle cell. Muscles are composed of tubular cells called myocytes, known as muscle fibers in striated muscle, and these cells in turn contain many chains of myofibrils.
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Titin Structure & Function Titin, a polypeptide chain protein that is greater than 1µm in length and 3-4 nm in width . The protein molecule has a molecular weight of up to approximately 4 Mda. Titin is a multi-domain structure that which is found to be composed of two types of domains similar to immunoglobulin (Ig) and fibronectin.
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What is creatinine? What is creatinine? Creatinine is a waste product that comes from the normal wear and tear on muscles of the body.Everyone has creatinine in their bloodstream. What is a normal level of creatinine? That depends on your age, race, gender, and body size.
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Fipronil Fipronil is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride (GluCl) channels, resulting in central nervous system toxicity.
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TBO-Filgrastim (Granix) TBO-Filgrastim (Granix) Tbo-filgrastim (Granix), manufactured by Teva, is a recombinant human granulocyte colony-stimulating factor (G-CSF) FDA approved to reduce the duration of severe neutropenia in adults with non-myeloid malignancies receiving myelosuppressive chemotherapy with significant evidence of febrile neutropenia (FN).