percentage of babies with down syndrome who have heart defects
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Congenital Heart Disease in Children with Down Syndrome Congenital Heart Disease in Children with Down Syndrome. Children with Down syndrome are at a much higher risk for congenital heart disease. As a comparison: the incidence of congenital heart disease in the general population is 0.8 percent. The incidence of congenital heart disease in children with Down syndrome is between 40-60 percent. Some heart defects can be left alone with careful monitoring while others require surgery to correct the problem. The following types of heart defects in children with Down syndrome are discussed below.
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Advanced maternal age A woman's risk of having a baby with chromosomal abnormalities increases with her age. Down syndrome is the most common chromosomal birth defect, and a woman's risk of having a baby with Down syndrome is: At age 20, 1 in 1,441. At age 25, 1 in 1,383. At age 30, 1 in 959.
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Down Syndrome: Trisomy 21 In the United States, Down syndrome occurs in 1 of every 800 infants with many as 6,000 children born with Down syndrome each year. It is estimated that about 85% of infants with Down syndrome survive one year and 50% of those will live longer than 50 years.
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More babies being born with Down's syndrome Around one in every 1,000 babies born has Down's syndrome, an incurable genetic disorder caused by the presence of an extra chromosome. Its physical effects include a characteristic flat face and slanting eyes, short stature, heart defects, and poor sight and hearing.
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What to know about Down syndrome The most common form of Down syndrome is known as Trisomy 21, a condition where individuals have 47 chromosomes in each cell instead of 46. This is caused by an error in cell division called nondisjunction, which leaves a sperm or egg cell with an extra copy of chromosome 21 before or at conception. Trisomy 21 accounts for 95% of Down syndrome cases, with 88% originating from nondisjunction of the mother's egg cell.
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Congenital Heart Disease According to the American Heart Association, about nine of every 1,000 babies born in the United States have a congenital (present at birth) heart defect. This is a problem that occurs as the baby's heart is developing during pregnancy, before the baby is born. Congenital heart defects are the most common birth defects. A baby's heart begins to develop at conception, but is completely formed by eight weeks into the pregnancy. Congenital heart defects happen during this crucial first eight weeks of the baby's development.
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Congenital Heart Defects Children who have genetic disorders, such as Down syndrome, often have congenital heart defects. In fact, half of all babies who have Down syndrome have congenital heart defects. Smoking during pregnancy also has been linked to several congenital heart defects, including septal defects. Researchers continue to search for the causes of congenital heart defects.
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- Risks to your baby. The miscarriage rate is 10 percent, only slightly higher than for women five years younger. At age 25, your chances of delivering a baby with Down syndrome are 1 in 1,250, and there's a 1 in 476 chance of having a baby with any chromosomal abnormality.et more infants with these disorders are born to women in their 20s because those in this age group have more babies and women past 35 are more likely to be offered screening tests and may elect to terminate a pregnancy in which the fetus has a birth defect.
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Birth Defect Statistics Approximately 150,000 babies are born each year with birth defects. Approximately 3 percent of all children born in the U.S. have a major malformation at birth. Many more show problems of developmental origin with time, e.g., 6-7 percent by 1 year of age and 12-14 percent by school age. Birth defects, including low birth weight babies, are the leading cause of infant mortality.
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Down syndrome (also called Trisomy 21) Down syndrome occurs in people of all races and economic levels. The risk increases with the mother's age (1 in 1250 for a 25 year old mother to 1 in 1000 at age 31, 1 in 400 at age 35, and about 1 in 100 at age 40). However, 80% of babies with Down syndrome are born to women under age 35 years.
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Down Syndrome Down syndrome is a genetic condition that causes delays in physical and intellectual development. It occurs in approximately one in every 800 live births. Individuals with Down syndrome have 47 chromosomes instead of the usual 46. It is the most frequently occurring chromosomal disorder.
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- There are a number of chromosome abnormalities associated with congenital heart defects. 1  Some of these include the following: 2  Down syndrome (trisomy 21) 3  Trisomy 18 and trisomy 13. 4  Turner's syndrome. 5  Cri-du-chat syndrome. 6  Wolf-Hirshhorn syndrome. 7  DiGeorge syndrome (22q11)
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- Most cases of Down syndrome pregnancies (and other chromosome problems) occur in older women. If birth defects testing is done in the early part of the second trimester, fetuses with birth defects are found in about: 1  1 out of 132 women age 35. 2  1 out of 83 women age 37.  1 out of 40 women age 40.
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Complications Heart problems. Around half of children with Down's syndrome are born with a congenital heart defect. The most common defect to affect children with Down's syndrome is a septal defect. This is a hole inside one of the walls that separate the four chambers of the heart, often referred to as a hole in the heart.
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Overview 1 About 95 percent of the time, Down syndrome is caused by trisomy 21 — the child has three copies of chromosome 21 (instead of the usual two copies) in all cells. 2  This is caused by abnormal cell division during the development of the sperm cell or the egg cell.3  Mosaic Down syndrome. Mosaic Down syndrome. 2  In this rare form of Down syndrome, children have some cells with an extra copy of chromosome 21. 3  This mosaic of normal and abnormal cells is caused by abnormal cell division after fertilization. 4  Translocation Down syndrome.
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- 1 Although there is a clear relationship between advancing maternal age and the risk of Trisomy 21, 70% of Down Syndrome infants are born to mothers below the age of 35 years. 2  The risk of Trisomy 21 in the general population primarily depends on maternal age.
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- This is the case for the common trisomy form of Down syndrome but not the rare translocational form. Women who are 20 years old apparently have the lowest chance (1 in 2000) of having a Down syndrome child. Women do not reach the average risk rate of 1 in 800 until they are about 30.
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Genes and human disease Each year approximately 3,000 to 5,000 children are born with this chromosome disorder and it is believed there are about 250,000 families in the United States of America who are affected by Down Syndrome. Sixty to 80 percent of children with Down Syndrome have hearing deficits. Forty to 45 percent of children with Down Syndrome have congenital heart disease. Intestinal abnormalities also occur at a higher frequency in children with Down Syndrome. Children with Down Syndrome often have more eye problems than other children who do not have this chromosome disorder.
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Congenital Heart Defects If your child has a congenital heart defect, you may think you did something wrong during your pregnancy to cause the problem. However, doctors often don't know why congenital heart defects occur. Heredity may play a role in some heart defects. For example, a parent who has a congenital heart defect may be more likely than other people to have a child with the defect. Rarely, more than one child in a family is born with a heart defect. Children who have genetic disorders, such as Down syndrome, often have congenital heart defects.
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What Causes Down Syndrome? The risk for someone with tranlocation trisomy 21 passing on the condition to a child is roughly 10 to 15 percent for women and three percent for men. Since translocation trisomy 21 only accounts for around four percent of people with Down syndrome, less than one percent of cases would be considered hereditary.
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About Down syndrome In the US, between 1979 and 2003, live birth prevalence increased by 31%, from 9.0 to 11.8 per 10,000 live births. People with Down syndrome are also living longer. Improved medical care in developed countries is now helping people with Down syndrome to live beyond 60 years - up from only 30 years in the 1970s. It has been estimated that there were 83,400 children and adolescents living in the USA in 2002.
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- 1 Nearly one of every 100 babies is born with a CHD. 2  Each year approximately 40,000 babies are born in the United States with a congenital heart defect. (Source: CHPHC)  Approximately two to three million individuals are thought to be living in the United States with CHDs.
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Top 30 Doctor insights on: Birth Defects Associated With Breech Babies About 3%: About 3 out of every 100 babies are born with some type of birth defect. Some can be very minor, and some are more serious. Some disease (like diabetes in the mother), or use of some medications in pregnancy can increase the risk of a baby having a birth defect. ...Read more.
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How many people in the world have Down syndrome? World-wide, over 5.8 million people have Down syndrome. (This condition affects people of all ages, races, religions and economic situations.). Approximately 1 in every 1,000 babies has Down syndrome. In the UK It is estimated that there are about 60,000 people with Down syndrome living in the UK. About 600 babies with Down syndrome are born in the UK each year.