Synephrine is an endogenous alkaloid that can also be found in citrus fruits  Evodia  and Zanthoxylum Synephrine exhibits vasoconstrictive  anti-inflammatory  antibacterial  and gastrointestinal motility modulating activities Synephrine acts as a positive inotrope  activating adrenergic receptors (displaying partial selectivity for α-adrenergic receptors)  TAAR-1 receptors  and 5-HT receptors