Abstract: Epigenetic modifiers are increasingly being implicated as playing major roles in many cellular and biological processes  such as cell growth  differentiation  lifespan  selfrenewal  cancer  and metastasis Epigenetic modifying proteins such as Enhancer of Zeste homology 2 (EZH2)  Lysine demethylase 6A (KDM6A) regulates chromatin structure through the addition or removal histone three lysine twenty seven (H3K27) tri methylation (me3) modification