The Systems Pharmacology group led by Jordi Mestres  performs research at the interface between chemistry  biology and informatics to develop novel computational approaches to design safer  more efficacious  drugs In this respect  the group is actively involved in several initiatives to explore the mechanisms of action leading to severe adverse drug reactions  with special emphasis in cardiotoxicity and hepatotoxicity  and to investigate the impact of the human endogenous metabolome on the efficacy and safety of drugs