ABSTRACT: In response to microenvironmental signals macrophages undergo different activation  indicated as classic/M1 and alternative/M2 polarization C-Myc transcription factor could be an essential player in M2 polarization Functional relevance of c-Myc in M2 macrophage biology is investigated by evaluating the effect of 100-58F4  on the transcriptional profile induced on human macrophages by IL-4