› Author Affiliations Funding This work was supported by grants of the state initiative ‘health economy’ of the Ministries of Health and Economics  Rhineland-Palatinate  Germany (grant identifier: AZ623–1)  the Federal Ministry of Education and Research  Germany (grant identifier: BMBF 10E01003)  the Center for Translational Vascular Biology (CTVB) of the University Medical Center Mainz  Boehringer Ingelheim Pharma GmbH & Co