It's possible, of course, that in an alternate universe, where American high schools were truly academic institutions, the seriously disturbed Harris and Klebold might have open fire on the brains, but I doubt it; first of all because Harris and Klebold would have received some of the acceptance they craved on their own merits, and secondly because they would not have despised the school so for favoring the intellectual achievers.
Harris and Klebold didn't like the school favoring intellectuals because they weren't very smart themselves.