"Cannot Start Application" Error from IE when posting multipart/form data
<p>I am trying to resolve a problem that is happening on a couple of machines. 
I have a web application which is pure javascript (no plugins)</p>

<p>When the user is attempting to send one request to the server it generates an error dialog 
<a href="https://i.stack.imgur.com/zdGHF.png" rel="nofollow noreferrer"><img src="https://i.stack.imgur.com/zdGHF.png" alt="enter image description here"></a></p>

<p>The request is to a Tomcat Server and is multipart/form-data.</p>

<p>The details are as follows</p>

<pre><code>PLATFORM VERSION INFO
Windows             : 6.1.7601.65536 (Win32NT)
Common Language Runtime     : 4.0.30319.34209
System.Deployment.dll       : 4.0.30319.34280 built by: FX452RTMGDR
clr.dll             : 4.0.30319.34209 built by: FX452RTMGDR
dfdll.dll           : 4.0.30319.34280 built by: FX452RTMGDR
dfshim.dll          : 4.0.41209.0 (Main.041209-0000)

SOURCES
    Deployment url          : http://iacts01:8080/iActs/notification/addAttachment.action

ERROR SUMMARY
    Below is a summary of the errors, details of these errors are listed later in the log.
    * Activation of http://iacts01:8080/iActs/notification/addAttachment.action resulted in exception. Following failure messages were detected:
        + Downloading http://iacts01:8080/iActs/notification/addAttachment.action did not succeed.
        + The remote server returned an error: (403) Forbidden.

COMPONENT STORE TRANSACTION FAILURE SUMMARY
    No transaction error was detected.

WARNINGS
    There were no warnings during this operation.

OPERATION PROGRESS STATUS
    * [4/15/2016 1:34:29 PM] : Activation of http://iacts01:8080/iActs/notification/addAttachment.action has started.

ERROR DETAILS
    Following errors were detected during this operation.
    * [4/15/2016 1:34:29 PM] System.Deployment.Application.DeploymentDownloadException (Unknown subtype)
        - Downloading http://iacts01:8080/iActs/notification/addAttachment.action did not succeed.
        - Source: System.Deployment
        - Stack trace:
            at System.Deployment.Application.SystemNetDownloader.DownloadSingleFile(DownloadQueueItem next)
            at System.Deployment.Application.SystemNetDownloader.DownloadAllFiles()
            at System.Deployment.Application.FileDownloader.Download(SubscriptionState subState)
            at System.Deployment.Application.DownloadManager.DownloadManifestAsRawFile(Uri&amp; sourceUri, String targetPath, IDownloadNotification notification, DownloadOptions options, ServerInformation&amp; serverInformation)
            at System.Deployment.Application.DownloadManager.DownloadDeploymentManifestDirectBypass(SubscriptionStore subStore, Uri&amp; sourceUri, TempFile&amp; tempFile, SubscriptionState&amp; subState, IDownloadNotification notification, DownloadOptions options, ServerInformation&amp; serverInformation)
            at System.Deployment.Application.DownloadManager.DownloadDeploymentManifestBypass(SubscriptionStore subStore, Uri&amp; sourceUri, TempFile&amp; tempFile, SubscriptionState&amp; subState, IDownloadNotification notification, DownloadOptions options)
            at System.Deployment.Application.ApplicationActivator.PerformDeploymentActivation(Uri activationUri, Boolean isShortcut, String textualSubId, String deploymentProviderUrlFromExtension, BrowserSettings browserSettings, String&amp; errorPageUrl)
            at System.Deployment.Application.ApplicationActivator.ActivateDeploymentWorker(Object state)
        --- Inner Exception ---
        System.Net.WebException
        - The remote server returned an error: (403) Forbidden.
        - Source: System
        - Stack trace:
            at System.Net.HttpWebRequest.GetResponse()
            at System.Deployment.Application.SystemNetDownloader.DownloadSingleFile(DownloadQueueItem next)

COMPONENT STORE TRANSACTION DETAILS
    No transaction information is available.
</code></pre>

<p>I cannot work out what is causing this or how to fix it. 
All other calls to the server take place unhindered.
If I try with Chrome no issues occur. Unfortunately that is not a standard browser for the company and they cannot use it. </p>

<p>Any help would be appreciated. </p>