Reference assemblies should not be loaded for execution
<p>All of a sudden my website is throwing this error message when I try to debug it within Visual Studio. If I deploy the website, it works without any errors.</p>

<p>Any suggestions to resolve this error.</p>

<pre>
[ConfigurationErrorsException: Could not load file or assembly 'Microsoft.Win32.Primitives' or one of its dependencies. Reference assemblies should not be loaded for execution.  They can only be loaded in the Reflection-only loader context. (Exception from HRESULT: 0x80131058)]
   System.Web.Configuration.CompilationSection.LoadAssemblyHelper(String assemblyName, Boolean starDirective) +738
   System.Web.Configuration.CompilationSection.LoadAllAssembliesFromAppDomainBinDirectory() +217
   System.Web.Configuration.CompilationSection.LoadAssembly(AssemblyInfo ai) +130
   System.Web.Compilation.BuildManager.GetReferencedAssemblies(CompilationSection compConfig) +170
   System.Web.Compilation.BuildManager.GetPreStartInitMethodsFromReferencedAssemblies() +92
   System.Web.Compilation.BuildManager.CallPreStartInitMethods(String preStartInitListPath, Boolean& isRefAssemblyLoaded) +290
   System.Web.Compilation.BuildManager.ExecutePreAppStart() +157
   System.Web.Hosting.HostingEnvironment.Initialize(ApplicationManager appManager, IApplicationHost appHost, IConfigMapPathFactory configMapPathFactory, HostingEnvironmentParameters hostingParameters, PolicyLevel policyLevel, Exception appDomainCreationException) +531

[HttpException (0x80004005): Could not load file or assembly 'Microsoft.Win32.Primitives' or one of its dependencies. Reference assemblies should not be loaded for execution.  They can only be loaded in the Reflection-only loader context. (Exception from HRESULT: 0x80131058)]
   System.Web.HttpRuntime.FirstRequestInit(HttpContext context) +9946132
   System.Web.HttpRuntime.EnsureFirstRequestInit(HttpContext context) +90
   System.Web.HttpRuntime.ProcessRequestNotificationPrivate(IIS7WorkerRequest wr, HttpContext context) +261
</pre>