aadel chaudhuri , md phd
Assistant Professor, Radiation Oncology at Washington University School of Medicine in St. Louis
v scholar | assistant professor radiation oncology , genetics , biomedical engineering , computer science & engineering | ctdna working group leader washu school medicine & siteman cancer center
'm assistant professor physician-scientist washington university department radiation oncology joint appointment genetics computer science & engineering . ’ also v foundation v scholar , leader ctdna working group washington university school medicine siteman cancer center solid tumor therapeutic program . research focus using circulating tumor dna ( ctdna ) biomarker early cancer detection , therapeutic response assessment , minimal residual disease ( mrd ) detection ( http : //chaudhurilab.wustl.edu ) .
Washington University School of Medicine in St. Louis
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Assistant Professor, Radiation Oncology
Washington University School of Medicine in St. Louis
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Assistant Professor, Genetics
Washington University in St. Louis
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Assistant Professor, Computer Science
Washington University in St. Louis
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Assistant Professor, Biomedical Engineering
Springer Nature Group
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Editorial board member for Molecular Diagnosis & Therapy
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Editorial Board
AstraZeneca
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US Medical Diagnostics NSCLC Advisory Council
Daiichi Sankyo, Inc.
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Advisory Council
Geneoscopy
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Scientific Advisory Board
Roche
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Advisor
NuProbe, Inc.
https://www.linkedin.com/company/nuprobe
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Consultant
Tempus, Inc.
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Consultant
Guidepoint
https://www.linkedin.com/company/guidepoint
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Healthcare Consultant
Stanford Health Care
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Stanford, California
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Chief Resident, Radiation Oncology
Stanford Health Care
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Holman Research Pathway
Stanford, CA
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Resident Physician, Radiation Oncology
Stanford University
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Circulating tumor DNA research
Laboratory of Maximilian Diehn, MD PhD and Ash Alizadeh, MD PhD
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Postdoctoral Research Scientist
Oscar Health
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Consultant
Scripps Health
https://www.linkedin.com/company/scripps-health
Transitional year residency internship with a focus on internal medicine
San Diego, CA
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Resident Physician
The Scripps Research Institute
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Laboratory of Peter Kuhn, PhD
La Jolla, California
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Visiting Scientist
Howard Hughes Medical Institute and Caltech
Laboratory of David Baltimore, PhD
Pasadena, CA
HHMI Medical Research Fellow
Doctor of Medicine (M.D.)
Scholarly Concentration: Molecular Basis of Medicine
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Stanford University School of Medicine
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Doctor of Philosophy (Ph.D.)
Laboratory of David Baltimore, PhD - MicroRNAs in the immune/hematopoietic system
Biology
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Caltech
https://www.linkedin.com/school/california-institute-of-technology/
Bachelor’s Degree
Laboratory of Phillip Sharp, PhD - Prediction of microRNA targets; Varsity Lightweight Rowing; Tau Beta Pi; Zeta Beta Tau; Alpha Chi Sigma
Biology (Major), Electrical Engineering/Computer Science (Major), Biomedical Engineering (Minor)
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Massachusetts Institute of Technology
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Review of urine tumor DNA based approaches to bladder cancer detection and surveillance.
Emerging Roles of Urine-Based Tumor DNA Analysis in Bladder Cancer Management
JCO Precision Oncology
https://ascopubs.org/doi/abs/10.1200/PO.20.00060
We showcase the EnhanceAR-Seq method to track alterations in the Androgen Receptor gene locus including its upstream enhancer, and demonstrate the ability to sensitively identify resistance to AR-directed therapy.
Cell-Free DNA Alterations in the AR Enhancer and Locus Predict Resistance to AR-Directed Therapy in Patients With Metastatic Prostate Cancer
JCO Precision Oncology
https://ascopubs.org/doi/abs/10.1200/PO.20.00047?journalCode=po
Circulating tumor DNA (ctDNA) is a component of cell-free DNA that is shed by malignant tumors into the bloodstream and other bodily fluids. Levels of ctDNA are typically low, particularly in patients with localized disease, requiring highly sophisticated methods for detection and quantification. Multiple liquid biopsy methods have been developed for ctDNA analysis in solid tumor malignancies and are now enabling detection and assessment of earlier stages of disease, post-treatment molecular residual disease (MRD), resistance to targeted systemic therapy, and tumor mutational burden. Understanding ctDNA biology, mechanisms of release, and clearance and size characteristics, in conjunction with the application of molecular barcoding and targeted error correction, have increased the sensitivity and specificity of ctDNA detection techniques. Combinatorial approaches including integration of ctDNA data with circulating protein biomarkers may further improve assay sensitivity and broaden the scope of ctDNA applications. Circulating viral DNA may be utilized to monitor disease in some virally induced malignancies. In spite of increasingly accurate methods of ctDNA detection, results need to be interpreted with caution given that somatic mosaicisms such as clonal hematopoiesis of indeterminate potential (CHIP) may give rise to genetic variants in the bloodstream unrelated to solid tumors, and the limited concordance observed between different commercial platforms. Overall, highly precise ctDNA detection and quantification methods have the potential to transform clinical practice via non-invasive monitoring of solid tumor malignancies, residual disease detection at earlier timepoints than standard clinical and/or imaging surveillance, and treatment personalization based on real-time assessment of the tumor genomic landscape.
Detection of Solid Tumor Molecular Residual Disease (MRD) Using Circulating Tumor DNA (ctDNA)
Molecular Diagnosis & Therapy
https://link.springer.com/article/10.1007%2Fs40291-019-00390-5
Identifying molecular residual disease (MRD) after treatment of localized lung cancer could facilitate early intervention and personalization of adjuvant therapies. Here we apply Cancer Personalized Profiling by Deep Sequencing (CAPP-Seq) circulating tumor DNA (ctDNA) analysis to 255 samples from 40 patients treated with curative intent for stage I-III lung cancer and 54 healthy adults. In 94% of evaluable patients experiencing recurrence, ctDNA was detectable in the first post-treatment blood sample, indicating reliable identification of MRD. Post-treatment ctDNA detection preceded radiographic progression in 72% of patients by a median of 5.2 months and 53% of patients harbored ctDNA mutation profiles associated with favorable responses to tyrosine kinase inhibitors or immune checkpoint blockade. Collectively, these results indicate that ctDNA MRD in lung cancer patients can be accurately detected using CAPP-Seq and may allow personalized adjuvant treatment while disease burden is lowest.
Early detection of molecular residual disease in localized lung cancer by circulating tumor DNA profiling
Cancer Discovery
http://cancerdiscovery.aacrjournals.org/content/early/2017/09/22/2159-8290.CD-17-0716
Tumors continually shed DNA into the blood where it can be detected as circulating tumor DNA (ctDNA). Although this phenomenon has been recognized for decades, techniques that are sensitive and specific enough to robustly detect ctDNA have only become available recently. Quantification of ctDNA represents a new approach for cancer detection and disease burden quantification that has the potential to revolutionize response assessment and personalized treatment in radiation oncology. Analysis of ctDNA has many potential applications, including detection of minimal residual disease following radiotherapy, non- invasive tumor genotyping, and early detection of tumor recurrence. Ultimately, ctDNA-based assays could lead to personalization of therapy based on identification of somatic alterations present in tumors and changes in ctDNA concentrations before and after treatment. In this review, we discuss methods of ctDNA detection and clinical applications of ctDNA-based biomarkers in radiation oncology, with a focus on recently developed techniques that use next- generation sequencing for ctDNA quantification.
Predicting Radiotherapy Responses and Treatment Outcomes Through Analysis of Circulating Tumor DNA
Seminars in Radiation Oncology
http://www.semradonc.com/article/S1053-4296(15)00054-5/fulltext
American Board of Radiology
Radiation Oncology
https://www.linkedin.com/in/michaeldworkin
San Francisco Bay Area
Michael Dworkin
Radiation Oncology Resident At Stanford
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United States
Wafa Asha
Advanced Radiation Oncology Fellow at Cleveland Clinic
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Greater Boston
Susan McDuff
Assistant Professor of Radiation Oncology at Duke Cancer Institute
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Jacksonville, FL
Daniel Trifiletti
Associate Professor of Radiation Oncology, Neurological Surgery, and Cancer Biology
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Philadelphia, PA
Tamim Khaddash
Interventional Radiologist at Penn IR
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Boca Raton, FL
Tim Yates
Interventional Radiologist at Palm Vascular
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Boston, MA
Filipe A. Moura
Research Fellow at TIMI Study Group and Cardiology Fellow at Brigham and Women's Hospital/Harvard Medical School
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New York City Metropolitan Area
Mark Hurwitz
Director/Chair of Radiation Medicine at Westchester Medical Center Health/New York Medical College
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North Port-Sarasota Area
Kevin Kadakia
Physician, Chief Executive Officer at Hospital to Hospitality LLC
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New York City Metropolitan Area
Zachary Waxman, MD
Software Engineer and MD at NextSense
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Souderton, PA
Bonnie J Miller
Assistant Vice President Oncology Services
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Rochester, MN
Nathan Smischney
Anesthesiologist at Mayo Clinic
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Greater Houston
Matthew Palmer
President and Chief Operating Officer @
Legion Healthcare Partners
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San Francisco Bay Area
Osama Mohamad, MD PhD
Assistant Professor of Radiation Oncology at University of California, San Francisco
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New York, NY
Hamza Numan Gokozan
Assistant Professor of Pathology and Laboratory Medicine at Weill Cornell Medicine
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Nashville, TN
Jonathan Brown
Assistant Professor at Vanderbilt University Medical Center
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Silver Spring, MD
Avi Rosenberg
Assistant Professor at Johns Hopkins University
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Atlanta Metropolitan Area
Moji Ariyo, MD FACP
Assistant Professor at Emory University School of Medicine
Liked by Aadel Chaudhuri, MD PhD
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A constellation of remarkable Stanford alumnae have taken giant leaps for women in space. 🚀• Sally Ride: first American woman in space •Mae…
Liked by Aadel Chaudhuri, MD PhD
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Honored to fly to NYC to appear on the Tamron Hall show and break an official Guinness World Records title on national TV in the show about just…
Liked by Aadel Chaudhuri, MD PhD
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We are pleased to announce that Yezdan Badrakhan has joined MUFG as Head of U.S. Esoteric ABS. Yezdan will be responsible for continuing to grow our…
Genomics: Next Generation DNA Sequencing (NGS) and Microarray
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NGS (Next Generation Sequencing)
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MIT Massachusetts Institute of Technology Alumni
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AACR Early-career Researcher Network
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ASTRO - American Society for Radiation Oncology
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Tau Beta Pi Engineering Honor Society
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