aaron meyer
Assistant Professor at University of California, Los Angeles
University of California, Los Angeles
https://www.linkedin.com/company/ucla
Greater Los Angeles Area
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Assistant Professor
Massachusetts Institute of Technology (MIT)
https://www.linkedin.com/company/mit
Greater Boston Area
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Research Fellow
Ph.D.
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Massachusetts Institute of Technology
https://www.linkedin.com/school/mit/
B.Eng.
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University of California, Los Angeles
https://www.linkedin.com/school/ucla/
Many immune receptors transduce activation across the plasma membrane through their clustering. With Fcγ receptors (FcγRs), this clustering is driven by binding to antibodies of differing affinities that are in turn bound to multivalent antigen. As a consequence of this activation mechanism, accounting for and rationally manipulating immunoglobulin (Ig)G effector function is complicated by, among other factors, differing affinities between FcγR species and changes in the valency of antigen binding. In this study, we show that a model of multivalent receptor-ligand binding can effectively account for the contribution of IgG-FcγR affinity and immune complex valency. This model in turn enables us to make specific predictions about the effect of immune complexes of defined composition. In total, these results enable both rational immune complex design for a desired IgG effector function and the deconvolution of effector function by immune complexes.
Dissecting FcγR Regulation through a Multivalent Binding Model
Cell Systems
https://doi.org/10.1016/j.cels.2018.05.018
The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells
Science Signaling
http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2004155
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling
PNAS
http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23674691&retmode=ref&cmd=prlinks
Growth factor–induced migration is a critical step in the dissemination and metastasis of solid tumors. Although differences in properties characterizing cell migration on two-dimensional (2D) substrata versus within three-dimensional (3D) matrices have been noted for particular growth factor stimuli, the 2D approach remains in more common use as an efficient surrogate, especially for high-throughput experiments. We therefore were motivated to investigate which migration properties measured in various 2D assays might be reflective of 3D migratory behavioral responses. We used human triple-negative breast cancer lines stimulated by a panel of receptor tyrosine kinase ligands relevant to mammary carcinoma progression. Whereas 2D migration properties did not correlate well with 3D behavior across multiple growth factors, we found that increased membrane protrusion elicited by growth factor stimulation did relate robustly to enhanced 3D migration properties of the MDA-MB-231 and MDA-MB-157 lines. Interestingly, we observed this to be a more reliable relationship than cognate receptor expression or activation levels across these and two additional mammary tumor lines.
2D protrusion but not motility predicts growth factor–induced cancer cell migration in 3D collagen
Journal of Cell Biology
http://jcb.rupress.org/content/197/6/721.long
Epithelial-mesenchymal transition (EMT), whether in developmental morphogenesis or malignant transformation, prominently involves modified cell motility behavior. While major advances have transpired in understanding the molecular pathways regulating the process of EMT induction per se by certain environmental stimuli, an important outstanding question is how the activities of signaling pathways governing motility yield the diverse movement behaviors characteristic of pre-induction versus post-induction states across a broad landscape of growth factor contexts. For the particular case of EMT induction in human mammary cells by ectopic expression of the transcription factor Twist, we found the migration responses to a panel of growth factors (EGF, HRG, IGF, HGF) dramatically disparate between confluent pre-Twist epithelial cells and sparsely distributed post-Twist mesenchymal cells - but that a computational model quantitatively integrating multiple key signaling node activities could nonetheless account for this full range of behavior. Moreover, motility in both conditions was successfully predicted a priori for an additional growth factor treatment (PDGF). While this signaling network state model could comprehend motility behavior globally, modulation of the network interactions underlying the altered pathway activities was identified by ascertaining differences in quantitative topological influences among the nodes between the two conditions.
Signaling network state predicts Twist-mediated effects on breast cell migration across diverse growth factor contexts
Molecular & Cellular Proteomics
http://www.mcponline.org/content/early/2011/08/10/mcp.M111.008433.short?rss=1
The concentration of biomarkers, such as DNA, prior to a subsequent detection step may facilitate the early detection of cancer, which could significantly increase chances for survival. In this study, the partitioning behavior of mammalian genomic DNA fragments in a two-phase aqueous micellar system was investigated using both experiment and theory. The micellar system was generated using the nonionic surfactant Triton X-114 and phosphate-buffered saline (PBS). Partition coefficients were measured under a variety of conditions and compared with our theoretical predictions. With this comparison, we demonstrated that the partitioning behavior of DNA fragments in this system is primarily driven by repulsive, steric, excluded-volume interactions that operate between the micelles and the DNA fragments, but is limited by the entrainment of micelle-poor, DNA-rich domains in the macroscopic micelle-rich phase. Furthermore, the volume ratio, that is, the volume of the top, micelle-poor phase divided by that of the bottom, micelle-rich phase, was manipulated to concentrate DNA fragments in the top phase. Specifically, by decreasing the volume ratio from 1 to 1/10, we demonstrated proof-of-principle that the concentration of DNA fragments in the top phase could be increased two- to nine-fold in a predictive manner.
Concentration of mammalian genomic DNA using two-phase aqueous micellar systems
Biotechnology & Bioengineering
http://onlinelibrary.wiley.com/doi/10.1002/bit.22188/abstract
https://www.linkedin.com/in/farhad-parhami-ph-d-m-b-a-10907516
Los Angeles, CA
Farhad Parhami, Ph.D., M.B.A.
President & CEO at MAX BioPharma In.
https://www.linkedin.com/in/suraj-doshi
Los Angeles Metropolitan Area
Suraj Doshi
Computational and Systems Biology Student
https://www.linkedin.com/in/nikhil--patel
Los Angeles, CA
Nikhil Patel
UCLA Undergraduate Researcher | Icahn School of Medicine
https://www.linkedin.com/in/rickpinondelgado
San Diego, CA
Rick Bryan Piñon Delgado
Graduate Assistant at Latinx Resource Center - SDSU
https://www.linkedin.com/in/ricardoramos-martin
Lancaster, PA
Ricky Ramos
MIT -> Tesla
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Cambridge, MA
Leyla Isik
Postdoc at Massachusetts Institute of Technology (MIT) and Boston Children's Hospital, Harvard Medical School
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Frankfurt Rhine-Main Metropolitan Area
Simone B Moos, PhD
Product Manager at Elementar Analysensysteme GmbH
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Seattle, WA
Ezra Schiff
Senior Software Development Engineer at Intuitive Surgical
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Arlington, VA
Laure Katz
Vice President, Blue Nature & Co-Lead Implementation Blue Nature Alliance at Conservation International
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Washington DC-Baltimore Area
David T. Wang
Civil EIT / Geologist at ExxonMobil
https://www.linkedin.com/in/tientienchan
Cambridge, MA
Tien-Tien Chan
Principal at Nelson Nygaard
https://www.linkedin.com/in/jessica-audrey-lee
San Francisco, CA
Jessica Audrey Lee
Microbial ecologist and evolutionary biologist
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San Francisco Bay Area
Nik Sawe
Behavioral Economist & Neuroscientist at Stanford University
https://www.linkedin.com/in/elizabeth-villa-ucsd
San Diego, CA
Elizabeth Villa
HHMI Investigator and Associate Professor of Molecular Biology,  University of California San Diego
https://www.linkedin.com/in/evangelia-bellas-59b56547
Philadelphia, PA
Evangelia Bellas
Assistant Professor at Temple University
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Gainesville, FL
Olga Guryanova
Assistant Professor at University of Florida
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Atlanta, GA
Vijayakumar Velu
Assistant Professor at Emory University
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New York City Metropolitan Area
Thales Papagiannakopoulos
Associate Professor at New York University School of Medicine
https://www.linkedin.com/in/jill-steinbach-rankins-02084b6
Louisville, KY
Jill Steinbach-Rankins
R&D Principal Investigator, Associate Professor with Tenure, Bioengineering at University of Louisville
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The MIT Department of Biological Engineering and the National Academy of Engineering invite you to join them for the 2021 Bernard M. Gordon Prize for…
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Thanks! UCSF Rosenman Institute University of California, San FranciscoEncellin is excited for the chance to help advance novel therapies and…
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After 11 years of wearing many hats within sales organizations I am excited to bring my experiences and passion to a new space.  Today was my first…
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Sioux Falls, SD
Aaron Meyer
Director of Field Operations at Soukup Construction, Inc.
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Laguna Niguel, CA
Aaron Meyer
Trial Lawyer at Aaron Meyer Law
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Portland, OR
Aaron Meyer
Concert Rock Violinist, Aaron Meyer LLC
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Marion, IA
Aaron Meyer
Chiropractor at Collins Road Chiropractic
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Kansas City Metropolitan Area
Aaron Meyer
Logistics Manager at Central Plains Cement Company