Alex Aimetti
SVP, Scientific Affairs at Marinus Pharma
SVP, Scientific Affairs at Marinus Pharma
Marinus Pharma
https://www.linkedin.com/company/marinuspharma
Radnor, Pennsylvania, United States
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SVP, Scientific Affairs
Marinus Pharma
https://www.linkedin.com/company/marinuspharma
Radnor, PA and Cambridge, MA
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VP, Scientific Affairs
Marinus Pharma
https://www.linkedin.com/company/marinuspharma
Radnor, PA and Cambridge, MA
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Head of Scientific Affairs
InVivo Therapeutics
https://www.linkedin.com/company/invivo-therapeutics
•	Identify and build relationships with medical community KOLs (neurosurgeons and PM&R physicians) to educate them on our therapeutic approach and clinical data to help support future adoption, reimbursement, and advocacy.  
•	Lead the establishment and management of clinical research alliances.  Initiated four collaborative projects with influential physicians and organizations designed to enhance the product’s value proposition.
•	Lead the development of the company's scientific and clinical communication strategy and actively tracks its execution.  
•	Manage all pharmacoeconomic analyses which serve as a foundation for the product’s value dossier.  Research resulted in one co-authored peer-reviewed publication.
•	Create all scientific/medical communication documents (presentations, abstracts, and posters).
•	Deep experience conducting primary and secondary market research to understand epidemiology, product perception, and customer adoption.
•	Past member of diligence teams evaluating potential business opportunities.  Responsibilities focused on technology, IP, and market assessments.
•	Reported up to CEO and Chief Commercial Officer
Cambridge, MA
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Product Strategy & Medical Education
InVivo Therapeutics
https://www.linkedin.com/company/invivo-therapeutics
•	Led biomaterial platform development programs for drug delivery and tissue engineering applications. Research has resulted in 4 patent filings, 4 publications, and 1 manuscript in preparation.
•	Contributions resulted in FDA-approved First-in-Human clinical trial to assess the safety and probable benefit of a Class III Medical Device for use following acute spinal cord injury
•	Managed up to six direct reports (including Ph.D. level engineers / chemists)
•	Promoted from Chemical Engineer, to Manager, to Associate R&D Director
Cambridge, MA
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Associate R&D Director, Biomaterials
MIT
https://www.linkedin.com/company/mit
•	Conceived and executed research plan to develop glucose-responsive, insulin-delivering biomaterials to treat Type I diabetes.
•	Research resulted in two patent filings and one first-author publication.

Advisors: Daniel Anderson & Robert Langer
Cambridge, MA
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Post-Doctoral Research Fellow - Langer Lab
University of Colorado at Boulder
https://www.linkedin.com/company/cuboulder
•	Developed peptide-functionalized hydrogels for drug delivery and regenerative medicine applications.
     -	     Inflammatory enzyme triggered drug delivery
     -	     Protective macroencapsulation of β-cells for T1D applications
•	Research resulted in one patent filing and four first-authored publications.

Thesis title: Synthetic peptide design for functionalized hydrogels: Development of cellularly responsive drug delivery platforms and cyclic, multivalent peptide derivatives using radical-mediated thiol-ene/thiol-yne chemistries.

Thesis Advisor: Dr. Kristi S. Anseth
Boulder, CO
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Research Assistant - Ph.D. Student
Ph.D.
Chemical & Biological Engineering
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University of Colorado Boulder
https://www.linkedin.com/school/cuboulder/
BS
Interdisciplinary Project (Davos, Switzerland) – As part of a multidisciplinary team we provided a detailed assessment of the socioeconomic impact the Swiss Federal Institute for Snow and Avalanche Research had on the surrounding region.
Biomedical Engineering
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Worcester Polytechnic Institute
https://www.linkedin.com/school/worcester-polytechnic-institute/
Hydrogels with covalently incorporated trehalose are synthesized using thiol-ene Michael addition. Trehalose hydrogels afford prolonged stabilization and ­controlled release of model enzymes in vitro and in vivo as well as preservation of protein stability under heat and ­lyophilization stressors. Strong and ­ordered hydrogen bonding interactions within covalently incorporated trehalose hydrogels represent a possible mechanism for protein stabilization.
Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules
Advanced Healthcare Materials
http://onlinelibrary.wiley.com.libproxy.mit.edu/doi/10.1002/adhm.201500334/abstract
A transesterfication reaction is used to synthesize tri-thiol-functionalized-ethoxylated polyols that are combined with polyethylene glycol diacrylates to form a biodegradable hydrogel library. Hydrogels display nonswelling equilibration and offer temporal control over material degradation and the release of biomolecules. The demonstrated in vitro biocompatibility makes this a versatile platform that can be used for local drug delivery to volume-constrained anatomical sites.
Synthesis and characterization of a library of in-situ curing, nonswelling ethoxylated polyol thiol-ene hydrogels for tailorable macromolecule delivery.
Advanced materials (Deerfield Beach, Fla.)
http://www.ncbi.nlm.nih.gov/pubmed/25381960?report=xml&format=text
Regulating MCP-1 diffusion in affinity hydrogels for enhancing immuno-isolation
Journal of Controlled Release (142) 384-391
A novel enzyme-responsive hydrogel drug delivery system was developed with the potential to treat inflammation locally. Human neutrophil elastase (HNE) is a serine protease secreted by neutrophils which are the first cells recruited to inflammatory sites. We exploited this cell-secreted enzyme as a biological cue for controlled release. HNE sensitive peptide linkers were immobilized within poly(ethylene glycol) hydrogels using photopolymerization techniques. The kinetics of the enzyme reaction within the gel was tailored by varying the amino acid residues present in the P1 and P1′ substrate positions (immediately adjacent to cleavage location). A novel FRET-based hydrogel platform was designed to characterize the accessibility of the substrate within the cross-linked, macroscopic hydrogel. Lastly, a diffusion-reaction mathematical model with Michaelis−Menten kinetics was developed to predict the overall release profile and captured the initial 80% of the experimentally observed release. The hydrogel platform presented shows highly controlled release kinetics with potential applications in cellular responsive drug delivery.
Human Neutrophil Elastase Responsive Delivery from Poly(ethylene glycol) Hydrogels
Biomacromolecules
http://pubs.acs.org/doi/abs/10.1021/bm9000926
Click on "Google Scholar" to see a current list of publications and patents.
Google Scholar
http://scholar.google.com/citations?user=jMmf7uQAAAAJ&hl=en
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We came a long way… but today we’re putting EEG #biomarkers  on the map in AD! Exciting advances in #EEG #connectivity …. at ADPD2022 in Barcelona…
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AllStripes made Forbes America’s Best Startup Employers 2022 list! At AllStripes, our dedication to the rare disease community and mission to unlock…
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I'm grateful to Ron Leuty's for his diligence to learn about  Seer, and to highlight our bold vision to imagine and pioneer new ways to decode the…
CU Boulder Chemical Engineering Alumni and Friends
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Global Drug Development Leaders
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