Anthony Anselmo
Lead Bioinformaticist at Dana-Farber Cancer Institute
Lead Bioinformaticist, Center for Cancer Genomics at Dana-Farber Cancer Institute
Dana-Farber Cancer Institute
https://www.linkedin.com/company/dana-farber-cancer-institute
Center for Cancer Genomics (CCG)
Department of Medical Oncology
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Lead Bioinformaticist
Dana-Farber Cancer Institute
https://www.linkedin.com/company/dana-farber-cancer-institute
Center for Cancer Genome Discovery (CCGD)
Department of Medical Oncology
Boston, MA
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Bioinformatics Analyst III
PatientsLikeMe
https://www.linkedin.com/company/patientslikeme
Analytics Group
Department of Biocomputing
Cambridge, MA
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Senior Scientist _ Computational Biology
Massachusetts General Hospital
https://www.linkedin.com/company/massachusetts-general-hospital
Bioinformatics Core Facility
Department of Molecular Biology
http://molbio.mgh.harvard.edu/department/bioinformatics

NGS analysis, included, but not limited to:
RNA-seq, ChIP-seq, RIP-seq, Variant Analysis, Microarray Analysis
Greater Boston Area
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Bioinformatics Specialist II
Sanofi Pasteur
https://www.linkedin.com/company/sanofi
Internal Web Development and Maintenance:
LAMP stack (RedHat(linux), Apache2, MySQL, Python)
Django-1.4.1/python-2.7 platform
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Designed, developed, and deployed server-side bioinformatics functionalities, including multiple sequence alignment (clustalw) and protein motif search.
Cambridge, MA
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R&D Information Services Specialist
Harvard Medical School
https://www.linkedin.com/company/harvard-medical-school
Laboratory of Stephen Elledge, PhD
Boston, MA
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Research Scientist (part-time)
Harvard Medical School
https://www.linkedin.com/company/harvard-medical-school
Laboratory of Stephen Elledge, PhD
Boston, MA
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Lab Manager/ Research Scientist
Cell Applications, Inc.
https://www.linkedin.com/company/cell-applications-inc-
San Diego, CA
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Sr. Assay Development Scientist
The Scripps Research Institute
https://www.linkedin.com/company/the-scripps-research-institute
Laboratory of Gary Bokoch, PhD
La Jolla, CA
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Postdoctoral Fellow
UT Southwestern Medical Center
https://www.linkedin.com/company/utsw
Dallas, TX
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Postdoctoral Researcher
Novartis
https://www.linkedin.com/company/novartis
Basel, Switzerland
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Research Intern
Master's Degree
graduated May 2, 2014
Bioinformatics
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Northeastern University
https://www.linkedin.com/school/northeastern-university/
PhD
Cell and Molecular Biology
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UT Southwestern Medical Center
https://www.linkedin.com/school/utsw/
Bachelor of Science (B.S.)
Biochemistry
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Texas A&M University
https://www.linkedin.com/school/texas-a&m-university/
Abstract
Skeletal muscle harbors quiescent stem cells termed satellite cells and proliferative progenitors termed myoblasts, which play pivotal roles during muscle regeneration. However, current technology does not allow permanent capture of these cell populations in vitro. Here, we show that ectopic expression of the myogenic transcription factor MyoD, combined with exposure to small molecules, reprograms mouse fibroblasts into expandable induced myogenic progenitor cells (iMPCs). iMPCs express key skeletal muscle stem and progenitor cell markers including Pax7 and Myf5 and give rise to dystrophin-expressing myofibers upon transplantation in vivo. Notably, a subset of transplanted iMPCs maintain Pax7 expression and sustain serial regenerative responses. Similar to satellite cells, iMPCs originate from Pax7+ cells and require Pax7 itself for maintenance. Finally, we show that myogenic progenitor cell lines can be established from muscle tissue following small-molecule exposure alone. This study thus reports on a robust approach to derive expandable myogenic stem/progenitor-like cells from multiple cell types.
Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors.
Stem Cell Reports
https://www.ncbi.nlm.nih.gov/pubmed/29742392
Abstract
RNAi pathways detect and silence foreign nucleic acids such as viruses as well as endogenous genes in many species. The phylogenetic profile across eukaryotes of proteins that mediate key steps in RNAi is correlated with the profiles of multiple mRNA splicing proteins and with intron number, suggesting that RNAi may surveil mRNA splicing to detect the divergent or absent introns of viruses. Here we examine the role of mRNA splicing in Caenorhabditis elegans RNAi. We found that viable null mutations in U1 and U2 small nuclear ribonucleic protein (snRNP)-specific splicing factor genes cause defects in RNAi. The U1A ortholog rnp-2 is required for normal ERGO-1 Argonaute class 26G siRNA biogenesis, trans-splicing of the eri-6/7 transcript, and targeting of poorly conserved gene transcripts by WAGO Argonaute class 22G siRNAs. We found that gene transcripts engaged by the siRNA-generating machinery are poorly conserved, possess few introns, and often have introns that are divergent from introns with strong consensus splicing sites found in highly conserved genes. We present biochemical evidence that RNAi targeted transcripts are tightly bound to spliceosomes. These findings suggest multiple layers of regulation by the spliceosome at early steps of small RNA-mediated gene silencing.
The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes.
Genes Dev
https://www.ncbi.nlm.nih.gov/pubmed/29739806
Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
Nature Communications
https://www.ncbi.nlm.nih.gov/pubmed/28485378
Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression
ELife
https://www.ncbi.nlm.nih.gov/pubmed/28477407
T-Helper 17 Cell Cytokine Responses in Lyme Disease Correlate With Borrelia burgdorferi Antibodies During Early Infection and With Autoantibodies Late in the Illness in Patients With Antibiotic-Refractory Lyme Arthritis.
Clin Inf Dis
https://www.ncbi.nlm.nih.gov/pubmed/28077518
HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus
Frontiers in Microbiology
https://www.ncbi.nlm.nih.gov/pubmed/28265266
Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.
Genes and Development
https://www.ncbi.nlm.nih.gov/pubmed/28087713
Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway.
BMC Biol.
https://www.ncbi.nlm.nih.gov/pubmed/27927200
Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish.
J Exp. Med
https://www.ncbi.nlm.nih.gov/pubmed/27810924
SIKs control osteocyte responses to parathyroid hormone.
Nature Communications
https://www.ncbi.nlm.nih.gov/pubmed/27759007
T cell immune deficiency in zap70 mutant zebrafish.
Mol. Cell Bio.
https://www.ncbi.nlm.nih.gov/pubmed/27601584
Sox2 expression marks gastric stem and progenitor cells, raising important questions regarding the genes regulated by Sox2 and the role of Sox2 itself during stomach homeostasis and disease. By using ChIP-seq analysis, we have found that the majority of Sox2 targets in gastric epithelial cells are tissue specific and related to functions such as endoderm development, Wnt signaling, and gastric cancer. Unexpectedly, we found that Sox2 itself is dispensable for gastric stem cell and epithelial self-renewal, yet Sox2+ cells are highly susceptible to tumorigenesis in an Apc/Wnt-driven mouse model. Moreover, Sox2 loss enhances, rather than impairs, tumor formation in Apc-deficient gastric cells in vivo and in vitro by inducing Tcf/Lef-dependent transcription and upregulating intestinal metaplasia-associated genes, providing a mechanistic basis for the observed phenotype. Together, these data identify Sox2 as a context-dependent tumor suppressor protein that is dispensable for normal tissue regeneration but restrains stomach adenoma formation through modulation of Wnt-responsive and intestinal genes.
Sox2 Suppresses Gastric Tumorigenesis in Mice
Cell Reports
The microtubule-associated Rho activating factor GEF-H1 interacts with exocyst complex to regulate vesicle traffic.
Dev. Cell
https://www.ncbi.nlm.nih.gov/pubmed/22898781
Recurrent hemizygous deletions in cancers may optimize proliferative potential.
Science
https://www.ncbi.nlm.nih.gov/pubmed/22628553
Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI.
Cell Signal
https://www.ncbi.nlm.nih.gov/pubmed/19765647
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
PNAS
https://www.ncbi.nlm.nih.gov/pubmed/16832045
Protein kinase function and glutathionylation.
Biochem J
https://www.ncbi.nlm.nih.gov/pubmed/15270699
Broad spectrum identification of cellular small ubiquitin-related modifier (SUMO) substrate proteins.
J Biol Chem
https://www.ncbi.nlm.nih.gov/pubmed/15016812
CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation.
Current Biology
https://www.ncbi.nlm.nih.gov/pubmed/15028221
Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase.
Acta Crystallogr D Biol Crystallogr.
https://www.ncbi.nlm.nih.gov/pubmed/14646080
Critical contribution of linker proteins to Raf kinase activation.
J Biol Chem
https://www.ncbi.nlm.nih.gov/pubmed/11741918
https://www.linkedin.com/in/anthony-anselmo-7328515
Tampa, FL
Anthony Anselmo
Senior Vice President at Fifth Third Bank
https://au.linkedin.com/in/anthony-anselmo-b9090730
Greater Melbourne Area
Anthony Anselmo
Pharmacovigilance and Medical Information Manager at Vifor Pharma
https://www.linkedin.com/in/anthony-anselmo-807451161
Carlsbad, CA
Anthony Anselmo
Marketing Director at KingBenefits Insurance Solutions, Inc. & Vice President at Our Nicholas Foundation
https://www.linkedin.com/in/anthony-anselmo-24208384
St Louis, MO
Anthony Anselmo
Sales Supervisor at Republic Services
Texas A&M University Alumni
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NGS (Next Generation Sequencing)
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Northeastern University Bioinformatics Club
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UT Southwestern Graduate School of Biomedical Sciences
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Bioinformatics geeks
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