Aadil Javed
PHD Candidate at Ege University
Molecular and Cell Biologist
I am well adept at forming hypotheses and research questions undertaken in molecular and cell biology scenarios especially for understanding molecular signaling pathways involved in carcinogenesis.
I am a member of the Cancer Biology Laboratory at the department of bioengineering, Ege University, Turkey. My key responsibilities in our lab include carrying out experiments with prostate cancer and breast cancer cell lines for cell biology and E-coli strains for recombinant DNA preparations.  I also have experience working with HEK293T/Phoenix Ampho cell lines for the production of lentiviruses and retroviruses. Other experiences include DNA/RNA transfections, viral transductions, western blotting, flow cytometry, immunofluorescence imaging, and cellular assays, etc.
Ege University
https://tr.linkedin.com/company/ege-university
Thesis Title: The investigation of centrosome defects in the development of Prostate Cancer.
Major studies of the thesis included unraveling a novel centrosomal protein named 'HN1' and its role in Prostate Cancer development by applying gain of function, loss of function, and correlation strategies by utilizing the models of cancer cell lines and online transcriptomic databases.
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PHD Candidate
Livingston Research
https://tr.linkedin.com/company/livingston-research
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Content Writer
National University of Sciences & Technology (NUST)
https://tr.linkedin.com/company/nustofficial
Independent thesis project titled "Mycosynthesis, Characterization and Evaluation of Therapeutic Potentials of Silver Nanoparticles".
Atta-ur-Rahman School of Applied Biosciences (ASAB)
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Research Scholar
University of Veterinary and Animal sciences, Lahore
https://tr.linkedin.com/company/university-of-veterinary-and-animal-sciences-lahore
Worked in a project titled "Molecular Characterization of Newcastle Disease Virus in Pakistan and Development Approaches to Vaccine".
Learned about basic techniques used in Molecular Biology, Toxicology and Vaccine Laboratories, including: DNA extraction, PCR, Gel electrophoresis, PAGE, HPLC and Cell culture.
Quality Operations Laboratory & Institute of Biochemistry and Biotechnology
Research Internee
Self-employed
Taught O-levels courses on daily basis, as a part time job during my BS studies.
Lahore City
Tutor
Doctor of Philosophy - PhD
Biotechnology
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Ege University
https://tr.linkedin.com/school/ege-university/
Master’s Degree
Enrolled in 8 regular and 1 additional courses and worked on an independent project for MS thesis.
Healthcare Biotechnology
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National University of Sciences and Technology (NUST)
https://tr.linkedin.com/school/nustofficial/
Bachelor’s Degree
Graduated 2nd in Class of 2013, Institute of Biochemistry and Biotechnology (IBBt), University of Veterinary and Animal Sciences, Lahore.
Led cricket and table tennis teams of my department in intra-university competitions.
Received University Merit Scholarship, 2011 and 2012.
Dissertation titled “Hands on Experience Practices in Molecular Biology and Biotechnology”, 2013.
Biotechnology & Bioinformatics
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University of Veterinary and Animal Sciences, Pakistan
https://tr.linkedin.com/school/university-of-veterinary-and-animal-sciences-pakistan/
High School Education
Graduated 1st in class of 2009, Government Postgraduate College Jhelum.
Pre-Medicine/Pre-Medical Studies
Government Post Graduate College, Jhelum
Secondary School Education (Matriculation)
Graduated 2nd in class of 2007, National Foundation Academy Secondary School for Boys, Jhelum.
Participated in organizing different events like fun fairs, functions and annual days.
Represented my school in debating competitions at district level.
Prefect of Iqbal House, one of four houses of the school.
General Science
National Foundation Academy Secondary School for Boys, Jhelum
NUST BioReach Society
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Previous severe acute respiratory syndrome-coronavirus (SARS-CoV) outbreaks resulted in a cohort of preclinical studies that utilized various mice models for determining the pathogenesis of the infection, including the viral replication, spread, and mortality of the disease. Such studies have provided a framework upon which new investigations have been launched for understanding the outbreak of new coronavirus disease-19 (COVID-19) causing viral agents and their interaction with the host and its body. Recent investigations showed that the previous SARS-CoV and the recently discovered severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) both require the spike S protein to enter the host cell upon infection the binding with the receptors on the surface of the cells. The viral entry also requires proteases from the host cells. Since there are key similarities between the structure of the viruses and the construct of the viral transmission along with the spread inside the host's body in animal models. They were developed for the previous viral agent. The disease can be emulated or manipulated to bring forth novel investigations leading to key data that can broaden the sphere of COVID-19 studies being conducted. There are several different options to choose the right animal model for the question being raised in the experimental design with the pathogenesis of COVID-19. This chapter focused on the already established animal models for other coronavirus outbreaks and some of the strategies that can be exploited to develop new animal models. For COVID-19, research aimed at targeting the therapy or basic investigations for understanding cellular or organ level mechanisms involved in the disease.
Genetically Engineered Mouse Models for COVID- 19
Bentham Science Publishers
https://www.eurekaselect.com/197495/chapter/genetically-engineered-mouse-models-for-covid--1
Stem cells have long been a topic of interest around the globe. Now and then, stem cells are being studied for revealing their beneficial effects. Countries around the world are in a race in stem cell research. Stem cells possess some unique and considerable qualities that hardly any other cell to date has. The outbreak of novel coronavirus or coronavirus disease-19 (COVID-19) was located in Wuhan, China. After a few months, the episode was declared Pandemic by the World Health Organization (WHO) as it engulfed many countries worldwide. Since then, stem cells have gained more push in clinical as well as pre-clinical stage research studies. COVID-19 shares some molecular properties with other coronaviruses like severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS). Stem cells surprisingly showed some good outcomes in many patients infected with COVID-19. A lot of laboratory evaluation is being carried out to check the feasibility of different stem cells to be used in COVID-19 infected patients. This chapter discusses and highlights the possible interventions in COVID-19 using different lineages and bio-cultured stem cells.
Stem Cell Therapy for COVID-19
Bentham Science Publishers
https://www.eurekaselect.com/197513/chapter/stem-cell-therapy-for-covid-1
Prostate cancer is one of the most common cancer for men worldwide with advanced forms showing supernumerary or clustered centrosomes. Hematological and neurological expressed 1 (HN1) also known as Jupiter Microtubule Associated Homolog 1 (JPT1) belongs to a small poorly understood family of genes that are evolutionarily conserved across vertebrate species. The co-expression network of HN1 from the TCGA PRAD dataset indicates the putative role of HN1 in centrosome-related processes in the context of prostate cancer. HN1 expression is low in normal RWPE-1 cells as compared to cancerous androgen-responsive LNCaP and androgen insensitive PC-3 cells. HN1 overexpression resulted in differential response for cell proliferation and cell cycle changes in RWPE-1, LNCaP, and PC-3 cells. Since HN1 overexpression increased the proliferation rate in PC-3 cells, these cells were used for functional characterization of HN1 in advanced prostate carcinogenesis. Furthermore, alterations in HN expression led to an increase in abnormal to normal nuclei ratio and increased chromosomal aberrations in PC-3 cells. We observed the co-localization of HN1 with γ-tubulin foci in prostate cancer cells, further validated by immunoprecipitation. HN1 was observed as physically associated with γ-tubulin and its depletion led to increased γ-tubulin foci and disruption in microtubule spindle assembly. Higher HN1 expression was correlated with prostate cancer as compared to normal tissues. The restoration of HN1 expression after silencing suggested that it has a role in centrosome clustering, implicating a potential role of HN1 in cell division as well as in prostate carcinogenesis warranting further studies.
HN1 interacts with γ-tubulin to regulate centrosomes in advanced prostate cancer cells
Cell Cycle by Taylor & Francis Online
https://www.tandfonline.com/eprint/G7S7MTDBPAWSCPTVVRRV/full?target=10.1080%2F15384101.2021.1962624#.YRVF1cnQzrE.linkedin
SARS-CoV-2 belonging to Coronaviridae family of RNA viruses caused an epidemic in China, which led to a global pandemic of COVID-19. Various international and national authorities around the world have been attempting to halt the spread of the deadly virus by providing awareness about the disease including the daily figures of confirmed cases and mortalities related to the pandemic. At this early stage of this outbreak, healthcare officials and public, require the epidemiological patterns to understand the situation. Case fatality rate is one of the key parameter for epidemiology of an outbreak of this kind. In this study, we summarized the situation and timeline of confirmed cases of Turkey and compared it with European countries (with more than 5000 cases as of March 31 2020). We used linear regression analysis on cumulative number of cases and deaths for constructing a slope for estimating CFR values of COVID-19 in selected countries. We compared the computed CFR values of Turkey until 31st March (15 days since first COVID-19 death) with similar first fifteen days’ data since the report of first death from Italy, Spain, UK, France, Germany, Switzerland, Belgium, Austria, Netherlands and Portugal. Later, we computed CFR values for these countries from their cumulative confirmed cases and cumulative deaths until 31st March. Our findings suggest that the CFR of COVID-19 in Turkey at initial stages of the outbreak was similar to France. However, SARS-CoV-2 seemed to have spread quicker in Turkey since the report of first death, as compared to other countries based on the number of confirmed cases.
Case Fatality Rate estimation of COVID-19 for European Countries: Turkey’s Current Scenario Amidst a Global Pandemic; Comparison of Outbreaks with European Countries
Eurasian Journal of Medicine and Oncology
https://www.ejmo.org/10.14744/ejmo.2020.60998/pdf
A chapter (titled: Curcuminoids) in the 1st edition of the book Recent Advances in Natural Products Analysis.
Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included.
3.7 Curcuminoids
Elsevier
https://www.elsevier.com/books/recent-advances-in-natural-products-analysis/nabavi/978-0-12-816455-6
A chapter (titled: Stilbenoids) in the 1st edition of the book Recent Advances in Natural Products Analysis.
Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included.
3.5 Stilbenoids
Elsevier
https://www.elsevier.com/books/recent-advances-in-natural-products-analysis/nabavi/978-0-12-816455-6
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation of synovium, cartilage
damage and co-occurring of various other disorders. Significant improvement has been achieved in RA
therapeutics in last two decades. However, newer, more efficient and more cost-effective therapeutic applications are still needed to be developed. Current therapies in RA are mostly acting to restrict inflammation. Non steroidal anti inflammatory drugs (NSAIDs) and disease modifying antirheumatic drugs (DMARDs) are conventionally used in RA therapy. Studies showed higher efficacy of anticytokine therapy such as anti-IL-6 and anti-TNF. Rituximab, targeting B cells, after establishing its potential was approved to be used in combination with methotrexate in 2006. Abatacept, CLTA-4-IgG1, has been developed to block CD28 and CD80 or CD86 interaction leading to the termination T cell activation. Molecular inhibitors are relatively new in RA therapeutics such as tocilizumab, tofacitinib and baricitinib. FDA has approved tofacitinib to be used as a treatment for moderate andsevere RA. Future holds promising therapeutic options based on numerous studies. IL-12, IL-17 and IL-23 are the targets of future anticytokine therapies. Several lymphocyte targeting agents including ofatumumab, ocrelizumab and veltuzumab have been developed and are currently in phase II and phase III clinical trials. There is a vast range of potential targets in RA enabling us to expand the therapeutic options over the next decade.
RHEUMATOID ARTHRITIS THERAPIES: PRESENT AND FUTURE
PAKISTAN ARMED FORCES MEDICAL JOURNAL
http://www.pafmj.org/showdetails.php?id=55&t=r
A review focused on the current status of nanoparticles in specific systems that work against viruses, using the conceptual translation of the nano-scale moieties. Different targets for various virology related entities, that are exploited and have resulted in promising aspects of targeting agents and nano-therapeutics are discussed in detail in this document.
Introduction to nanotechnological structures and their potential therapeutic uses in viral diseases.
Journal of Bio-Molecular Sciences
http://directsciences.com/files/i645ccmbbr3(1)%2001-17.pdf
Elsevier
Certificate of Reviewing
https://uk.linkedin.com/in/james-harris-b0a15a232
Londra
James Harris
Delegate Sales Executive
https://www.linkedin.com/in/chris-corbin-2a6a2233
Jupiter, FL
Chris Corbin
Associate Director of Marketing
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Chengdu
David Zhang
猎头顾问 - 上海瀚仕企业管理咨询有限公司
https://www.linkedin.com/in/julesamiller
New York, NY
JULES MILLER
VIRTUAL & Live Event/Conference/Content Producer, Marketer & Strategist - CONTENT RESEARCH & DEVELOPMENT, STRATEGY, PRODUCTION & MARKETING
https://uk.linkedin.com/in/alessia-valteroni-5008a4196
Londra
Alessia Valteroni
Delegate Sales Executive at Kisaco Research
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Ankara
İBRAHİM NAZLIGÜLOĞLU
Deck Cadet/Güverte Stajyeri
https://tr.linkedin.com/in/g%C3%B6khan-ektik-60b18a32
Türkiye
Gökhan EKTİK
ERMAKSAN şirketinde Web Developer
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Türkiye
İsmet Tarım
Credit and Risk Supervisor - Vestel
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İstanbul, Türkiye
Sukru Gulluoglu
Assistant Professor, Head of Department of Immunology at Marmara University
https://fr.linkedin.com/in/ali-korur-2a65525
Paris Metropol Bölgesi
Ali Korur
Semi Retired and enjoying Life.
https://tr.linkedin.com/in/halit-canatan-67b140144
Melikgazi
Halit CANATAN
Erciyes Üniversitesi'nde Öğretim Üyesi
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Çerkezköy
Orhan Şahin
Akripol Kimya şirketinde Vice Production ​Manager
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Ataşehir
faruk ulutaş
"Airled" de Danışman, yönetici
https://tr.linkedin.com/in/sel%C3%A7uk-kaya-40a22964
İstanbul, Türkiye
Selçuk KAYA
RE/MAX Türkiye 5. Seviye Profesyonel Gayrimenkul Uzmanı
https://pk.linkedin.com/in/saba-soomro-79b0b5225
Karaçi
Saba Soomro
Graphic designer
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Berg am Irchel
Rolf Schneider
Leiter Ersatzteillager und -Logistik bei Garage Otto Meier AG
https://tr.linkedin.com/in/bahtiyar-aksoy-a87594232
İzmir
Bahtiyar Aksoy
Sevkiyat - Ege Çelik Endüstrisi San. ve Tic. A. Ş.
https://cn.linkedin.com/in/chris-chenxiao-yu-63826476
Jing'an
CHRIS (CHENXIAO) YU
Event Manager at GenScript
Aadil Javed tarafından beğenildi
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Rise of 4D bioprinting technologies: A micro cancer robot biofabricated with 4D biomaterials and biorobotics & controlled by magnetic field for…
Aadil Javed tarafından beğenildi
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Congratulations to Dr. Eric Haura and all Moffitt authors for their research published in Molecular Cancer Research. This study defines mechanisms of…
Aadil Javed tarafından beğenildi
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Following a great initiative from Prof Pontikes at Ku Leuven, if you are a PhD student or a postdoc at a Ukrainian university/institute on a topic…
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Toronto, Kanada
Aadil J.
Assistant Marketing Manager
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Lahore District
Aadil Javed
Management Trainee at Shan Foods | CFA Level 1 Aspirant
https://ae.linkedin.com/in/aadil-javed-75211878
Birleşik Arap Emirlikleri
aadil javed
helper
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Loughborough
Aadil Javed
Research Chemist at Charnwood Molecular
🧫 Microbiology Professionals🔬
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Pharmaceutical/Biotechnology/Medical Devices & Scientific Opportunities
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Rx&D - Life Sciences R&D Professionals (Pharma, Biotech, Med Tech, Med Device, etc.)
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Society for Industrial Microbiology and Biotechnology  (SIMB)
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Bioinformatics Job News
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Royal Society of Biology
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Health & Biotechnology Management and Technology | Startups | Blockchain (BIG)
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Nanotechnology World Association
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Pharmaceutical, Biotech, Medical & Healthcare Network: Business, Jobs, Events & News
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3D cell biology : tools & techniques
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Clinical Research Jobs & News
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Biotech and Pharma Professionals
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Molecular Biology Network - Cell, Genetics, Neuroscience, Virology, Cancer, R & D, DNA - News & Jobs
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GENETICS Jobs - Scientific, Molecular, Medical Biotech Virology Immunology Coronavirus Life Sciences
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