dar
Senior Scientist at Chemistry
process chemist , r & chemist , medicinal chemist , project manager
• senior scientist 6+ year post-phd research experience organic chemistry . • independently proficient route scouting analytical skill , resulting synthesis drug , drug intermediate , synthetic molecule natural product . • demonstrated ability adapt , excel build relationship multi-disciplinary team around world . skill : multi-step total synthesis , natural product , methodology development , organocatalysis , biocatalysis , medicinal chemistry ( sar ) , drug discovery development , r & , project management , hplc ( chiral prep-hplc ) , flash chromatography , nmr ( 1d & 2d ) , lcm , gcms , hrms , uv , polarimetry , mestrenova , acdnmr , chemdraw , scifinder , reaxys . 'm open opportunity # ono . would happy connect & exchange experience ! let 's connect . willing relocate . ( email- roufdr99 @ gmail.com )
Chemistry
San Francisco, California, United States
Senior Scientist
University of Florida
https://www.linkedin.com/company/uflorida
•	Developed total synthesis of complex and challenging polyketide natural product nemamide fragments. 
•	Worked on the synthesis of small molecule ascarosides - pheromones (collaborative projects).
•	Synthesized cyclic and linear peptides by solid phase peptide synthesis.
•	Worked with dry reactions both at large (150g) and small scale (micrograms).
•	Developed excellent interpersonal, written and verbal communication skills demonstrated by participating in scientific discussions, conferences, presentations and reviewing papers
•	Analytical skills demonstrated by working on HPLC, MS, NMR and other instruments for method development, purification, isolation, and structural elucidation. 
•	Lab management skills developed by equipment maintenance, trouble shooting, ordering reagents/equipments and maintaining lab note books. 
•	Lab regulatory skills established by working as per EPA guidelines (GLPS), organizing chemical database, preparing laboratory for audits, and management of hazardous waste in compliance with Environmental Health & Safety guidelines (EH&S).
Gainesville, Florida Area
https://media-exp1.licdn.com/dms/image/C560BAQHkxnOuY0Xp9w/company-logo_100_100/0/1519856078337?e=1655942400&v=beta&t=i4mVKW2GsjJLoKFrpCcxsqspdOPr3iRQcUt3Wvx9BR0
Research Scientist
Doctor of Philosophy - PhD
Organic Chemistry
Csir-Indian Institute of Integrative Medicine
Mothers contribute cytoplasmic components to their progeny in a process called maternal provisioning. Provisioning is influenced by the parental environment, but the molecular pathways that transmit environmental cues between generations are not well understood. Here, we show that, in Caenorhabditis elegans, social cues modulate maternal provisioning to regulate gene silencing in offspring. Intergenerational signal transmission depends on a pheromone-sensing neuron and neuronal FMRFamide (Phe-Met-Arg-Phe)–like peptides. Parental FMRFamide-like peptide signaling dampens oxidative stress resistance and promotes the deposition of mRNAs for translational components in progeny, which, in turn, reduces gene silencing. This study identifies a previously unknown pathway for intergenerational communication that links neuronal responses to maternal provisioning. We suggest that loss of social cues in the parental environment represents an adverse environment that stimulates stress responses across generations.
Neuronal control of maternal provisioning in response to social cues
SCIENCE ADVANCES
https://www.science.org/doi/10.1126/sciadv.abf8782
Animals can adapt to dynamic environmental conditions by modulating their developmental programs. Understanding the genetic architecture and molecular mechanisms underlying developmental plasticity in response to changing environments is an important and emerging area of research. Here, we show a novel role of cAMP response element binding protein (CREB)-encoding crh-1 gene in developmental polyphenism of C. elegans. Under conditions that promote normal development in wild-type animals, crh-1 mutants inappropriately form transient pre-dauer (L2d) larvae and express the L2d marker gene. L2d formation in crh-1 mutants is specifically induced by the ascaroside pheromone ascr#5 (asc-ωC3; C3), and crh-1 functions autonomously in the ascr#5-sensing ASI neurons to inhibit L2d formation. Moreover, we find that CRH-1 directly binds upstream of the daf-7 TGF-β locus and promotes its expression in the ASI neurons. Taken together, these results provide new insight into how animals alter their developmental programs in response to environmental changes.
CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression
Plos Genetics
https://journals.plos.org/PLOSGENETICS/article?id=10.1371/journal.pgen.1009678
The nematode Caenorhabditis elegans produces a broad family of pheromones, known as the ascarosides, that are modified with a variety of groups derived from primary metabolism. These modifications are essential for the diverse activities of the ascarosides in development and various behaviors, including attraction, aggregation, avoidance, and foraging. The mechanism by which these different groups are added to the ascarosides is poorly understood. Here, we identify a family of over 30 enzymes, which are homologous to mammalian carboxylesterase (CES) enzymes, and show that a number of these enzymes are responsible for the selective addition of specific modifications to the ascarosides. Through stable isotope feeding experiments, we demonstrate the in vivo activity of the CES-like enzymes and provide direct evidence that the acyl-CoA synthetase ACS-7, which was previously implicated in the attachment of certain modifications to the ascarosides in C. elegans, instead activates the side chains of certain ascarosides for shortening through β-oxidation. Our data provide a key to the combinatorial logic that gives rise to different modified ascarosides, which should greatly facilitate the exploration of the specific biological functions of these pheromones in the worm.
A Large Family of Enzymes Responsible for the Modular Architecture of Nematode Pheromones
J. Am. Chem. Soc.
https://pubs.acs.org/doi/10.1021/jacs.0c04223
Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act respectively in the pheromone-sensing neuron ADL and the bacteria-sensing neuron AWA. Pheromone exposure inhibits learning by disrupting this balance: it activates ADL and increases expression of ins-16, and this cellular effect reduces AWA activity and AWA-expressed ins-4. The activities of the sensory neurons are required for learning and the expression of the ILPs. Interestingly, pheromones also promote the ingestion of pathogenic bacteria while increasing resistance to the pathogen. Thus, the balance of the ILP signals integrates social information into the learning process as part of a coordinated adaptive response that allows consumption of harmful food during times of high population density.
Pheromones Modulate Learning by Regulating the Balanced Signals of Two Insulin-like Peptides
Neuron, 2019/10/29 , https://doi.org/10.1016/j.neuron.2019.09.006
https://doi.org/10.1016/j.neuron.2019.09.006
Animals need to be able to alter their developmental and behavioral programs in response to changing environmental conditions. This developmental and behavioral plasticity is mainly mediated by changes in gene expression. The knowledge of the mechanisms by which environmental signals are transduced and integrated to modulate changes in sensory gene expression is limited. Exposure to ascaroside pheromone has been reported to alter the expression of a subset of putative G protein-coupled chemosensory receptor genes in the ASI chemosensory neurons of C. elegans (Kim et al., 2009; Nolan et al., 2002; Peckol et al., 1999). Here we show that ascaroside pheromone reversibly represses expression of the str-3 chemoreceptor gene in the ASI neurons. Repression of str-3 expression can be initiated only at the L1 stage, but expression is restored upon removal of ascarosides at any developmental stage
Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene in C. elegans.
Mol. Cells 2019; 42(1): 28~35
https://doi.org/10.14348/molcells.2018.0380
l-Vasicine is a quinazoline alkaloid with an electron dense ring and additional functionalities in its structure. Employing target oriented synthesis (TOS) based on in silico studies, molecules with significant docking scores containing different derivatives of l-vasicine as caps were synthesized. Interestingly, one molecule, i.e., 4a, which contained 3-hyroxypyrrolidine as a cap group and a six carbon long aliphatic chain as a linker was found to inhibit HDACs. 4a showed more specificity toward class I HDAC isoforms. Also 4a was found to be less cytotoxic toward normal cell lines as compared to cancer cell lines. 4a inhibited cancer cell growth and induced cell death by various mechanisms. However, 4a was found to induce cell death independent of ROS generation, and unlike many natural product based HDAC inhibitors, 4a was found to be nontoxic under in vivo conditions. Importantly, we for the first time report the possibility of using a 3-hydroxypyrrolidine cap for the synthesis of HDAC inhibitors with good potency.
Exploring Derivatives of Quinazoline Alkaloid l-Vasicine as Cap Groups in the Design and Biological Mechanistic Evaluation of Novel Antitumor Histone Deacetylase Inhibitors
ACS, J. Med. Chem. 2017,  60, 8, 3484-3497
https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00322
An efficient one-pot synthesis of a new class of 3,4,5-trisubstituted isoxazoline N-oxides/isoxazoles and dihydroisoxazoles is developed by a green approach from aromatic and aliphatic aldehydes by controlling the reaction conditions. Aldehydes were reacted with ethyl nitroacetate in the presence of DABCO as a catalyst under ultrasonication. In aromatic aldehydes, isoxazoline N-oxides were obtained exclusively when the reaction was carried out at 40 °C, but raising the temperature to 80 °C isoxazoles were formed selectively. Aliphatic aldehydes, on the other hand, gave a mixture of isoxazoline N-oxides and dihydroisoxazoles where the ratio of these depended on the bulk of the aliphatic chain on the aldehyde. This is the first method for the synthesis of aliphatic 4-substituted-3,5-bis(ethoxycarbonyl)-isoxazoline N-oxides and 4-substituted-3,5-bis(ethoxycarbonyl)-dihydroisoxazoles with good to excellent yields.
Divergent synthesis of polysubstituted isoxazoles, isoxazoline N-oxides, and dihydroisoxazoles by a one-pot cascade reaction
Tetrahedron 73 (4), 331–337
http://www.sciencedirect.com/science/article/pii/S004040201631273X
We report the chemical synthesis of Ofornine mimics from l-vasicine, structure-activity relationship studies and their in vivo screening for anti-hypertensive action in Wistar rats. It was observed that most of the analogs possessed anti-hypertensive effect; however, the duration of the effect was variable and mostly transient. The results demonstrated that the analogs 12, 13, 14, 15, and 16 showed a sharp and significant decrease in systolic and diastolic blood pressure for 30–60 min after intravenous administration. Analog (S)-(3-hydroxypyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone (8) showed a significant decrease in blood pressure in a dose dependent manner whose maximal response lowered to 79.29 ± 4.26 mmHg of SBP and 62.55 ± 2.9 of DBP at 10 mg/kg intravenous dose. Further, the significant anti-hypertensive effect of 8 lasted for about 2.5 h at 10 mg/kg dose. We also evaluated the acute toxicity of the analog 8 as per the OECD guidelines and the compound was found to be safe up to the dose of 2000 mg/kg body weight. These preclinical findings suggest that the analog 8 could be considered as a promising lead and a durable anti-hypertensive drug candidate and deserves further investigation. The SAR studies clearly showed that the amide, hydroxyl and pyridine ring plays important role in showing the activity.
Synthesis of Ofornine mimics from natural product l-vasicine as anti-hypertensive agents
Bioorganic & Medicinal Chemistry Volume 25, Issue 4, 15 February 2017, Pages 1440-1447
https://doi.org/10.1016/j.bmc.2017.01.006
Organocatalysis is an emerging and new field towards the direction of asymmetric synthesis and has shown a tremendous growth in 21st century. As the demand for chiral pharmaceuticals and chiral organic molecules is increasing immensely, different types of organocatalysts have been developed and used from time to time. The cinchona alkaloids and amino acid proline were the first organocatalysts used in this area followed by incredible growth in the form of urea/thiourea, DMAP, proline derivatives, squaramides, peptides, etc. The squaramide based organocatalysts are gaining impetus for asymmetric transformations and have shown remarkably good results in diverse type of reactions, wherein they usually act as linkers between two privileged skeletons. Due to its unique structural feature and wide application, squaramide holds a prominent and great potential in asymmetric synthesis. The present mini-review will briefly cover the squaramide based organocatalysts and the examples of organic reactions catalyzed by them.
Squaramide Based Organocatalysts in Organic Transformations
Current Organic Chemistry, 2016, 20,  2996-3013
http://www.ingentaconnect.com/contentone/ben/coc/2016/00000020/00000028/art00009#Refs
A novel series (13) of isoxazoline functionalized coumarins was synthesized through 1,3-dipolar cyclization of nitrile oxides with Allylated coumarins. Synthesis of effective and target selective immunostimulators through conjugation of diversely substituted isoxazolines and 7-hydroxycoumarins is the focus of the present article. The proposed synthetic scheme was observed to be highly regiospecific yielding attempted conjugates in good yield (>90%). Kinetic resolution of the racemates was carried out by employing lipase B from Candida antarctica (CALB). The synthesized compounds were screened in vitro and in vivo for their biological activities viz. toxicity and impact on splenocyte proliferation (T- and B-cell proliferation), antibody production (HA titre), delayed-type hypersensitivity reaction (DTH), T-cell subtypes (CD4 and CD8), cytokine production (IL-2, IFN-γ, and IL-4) and NO (macrophage) production. Our results establish that isoxazoline functionalized coumarins exhibit excellent immune potentiating activity especially compounds 2, 4 and 8 whose activity is more than that of Levimasole as standard. The structure activity relations are explained in light of the structural/functional aspects of tested compounds. To the best of our knowledge the presented work is first of its kind and is presaged to prove very useful for the design and synthesis of bis-heterocycle based novel, therapeutically selective and effective immunopotentiators.
Synthesis and immunopotentiating activity of novel isoxazoline functionalized coumarins
European Journal of Medicinal Chemistry 2016, 123, 10 , 90-104
http://www.sciencedirect.com/science/article/pii/S0223523416305748
The separation and recovery of useful products in high purities and yields during reaction workups minimizing or avoiding the use of volatile and toxic organic solvents is an important aspect
of a chemical reaction. Various green and environmentally friendly methods and techniques for
the isolation of desired products in high yields/purities are consistently being reported, therefore
increasing the overall efficacy of a process. In this review, we highlight some of these processes
including reactions with alternative solvents or under solvent-free conditions, the use of
microwave and ultrasound and synthesis under continuous flow conditions focusing on the
impacts of these methods on reaction work-ups.
Applying green processes and techniques to simplify reaction work-ups
Tetrahedron 2016, 72,  47, 7375-7391
https://doi.org/10.1016/j.tet.2016.09.055
A new approach was proposed for the synthesis of 2-azido-1,3-diols from easily available and inexpensive chiral pool synthon (R)-2,3-O-cyclohexylidene-d-glyceraldehyde, through Mitsunobu azidation of 1,2-diols. Both C(2) and C(1) azides in variable ratios were obtained in alkyl substituted diols with C(2) as the major one.
(R)-2,3-Cyclohexylideneglyceraldehyde, a chiral pool synthon for the synthesis of 2-azido-1,3-diols, 2015, 98, 823-833
Helvetica Chimica Acta
http://onlinelibrary.wiley.com/doi/10.1002/hlca.201400344/abstract
The heterocycles are the versatile compounds existing in almost all natural products and synthetic organic compounds, usually associated with one or the other biological activity. Among the heterocycles the thiazoles and benzothiazoles occupy a prominent position. They possess a broad range of biological activities and are found in many potent biologically active molecules and drugs such as vitamin thiamine, sulfathiazol (antimicrobial drug), ritonavir (antiretroviral drug), abafungin (antifungal drug) and tiazofurin (antineoplastic drug). The thiazole moiety is abundantly found in natural products while benzothiazole moiety is rare. In this review we disclose the literature reports of thiazoles and benzothiazoles possessing different biological activities.
Bioactive thiazole and benzothiazole derivatives,
European Journal of Medicinal Chemistry Volume 97, 5 June 2015, Pages 911-927
https://doi.org/10.1016/j.ejmech.2014.10.058
This short review highlights the various methods of formation of tetrahydropyranyl ethers (THPEs) as a method for the protection of simple alcohols as well as a diverse range of complex molecules using a variety of reagents and reaction conditions, i.e., acid catalyst, heterogeneous catalyst and neutral reagent mediated reactions. We also discuss their direct conversion to other useful functionalities.
Tetrahydropyranyl ether (THPE) formation in hydroxyl group protection and conversion to other useful functionalities
RSC Adv., 2014, 4, 21121–21130
https://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra02093f#!divAbstract
A common precursor strategy for the synthesis of bestatin hydrochloride, an anticancer agent, 1,3-diaminoalcohol, an amprenavir intermediate, and a syn-4-hydroxy-5-phenyl-γ-lactam intermediate of various bioactive molecules using an α,β-unsaturated ester as a common precursor is described. The protocol offers mild reaction conditions, good yields and excellent stereoselectivity.
Common Precursor Strategy for the Synthesis of Bestatin, Amprenavir intermediate and Syn-4-hydroxy-5-phenyl-γ-lactam
RSC Advances. 2014, 4, 17206-17209
https://pubs.rsc.org/en/content/articlelanding/2014/RA/C4RA00205A#!divAbstract
The first report of natural l-vasicine as tridentate chiral ligand for the enantioselective addition of diethylzinc to a variety of aliphatic and aromatic aldehydes is described. The ligand generates R-isomer of the secondary alcohols upto 98% ee. The quinazoline structure possibly imparts rigidity to the ligand and hence, consistently high enantioselectivity. The importance of the quinazoline ring was also supported by the reaction with other related ligands, partially lacking the structural features, thus resulting in poor enantioselectivity.
Vasicine as Tridentate Ligand for Enantioselective Addition of Diethyl Zinc to Aldehydes
Tetrahedron Letters, 2014, 55, 2639-2641
https://doi.org/10.1016/j.tetlet.2014.03.002
(S)-1,1′-Binaphthyl-2,2′-diol was prepared in high optical purity (∼98%) via Arthrobacter sp. lipase (MTCC No. 5125) catalyzed kinetic resolution. The immobilization of the substrate on a solid inert support significantly improved the enantioselectivity factor (E) by almost sixfolds, i.e. from ∼27 to >180. The effect of acyl substituents and co-solvents were also studied.
Arthrobacter sp. lipase catalyzed kinetic resolution of BINOL: The effect of substrate immobilization
J. Mol. Cat. B: Enzymatic, 2014, 101, 35-39.
https://www.sciencedirect.com/science/article/pii/S1381117713003731
Chiral‐center enantiomers have been shown to differ significantly in biological activity, pharmacodynamics, pharmacokinetics and toxicity. New developments in the stereoselective organic synthesis have enriched the vast literature of synthetic methodologies applicable to access natural products as well as bioactive molecules. These compounds also include new drugs, drug candidates and reagents used to explore biological processes. The article reviews the synthesis of optically pure drugs, biologically active intermediates and amino alcohols by using different methods.
Synthesis of single-enantiomer bioactive molecules: a brief overview.
Chirality 2014, 26, 63-78
https://doi.org/10.1002/chir.22268
The process describes the concise synthesis of (R/S)-enantiomers of doxazosin, an antidepressant drug and α-adrenergic receptor antagonists like prosympal, piperoxan, and dibozane in practical yields from easily available (R)-2,3-O-cyclohexylidene-d-glyceraldehyde and (S)-3-(benzyloxy)propane-1,2-diol.
A facile approach to chiral 1,4-benzodioxane toward the syntheses of doxazosin, prosympal, piperoxan and dibozane.
Tetrahedron Lett. 2013, 54, 6420-6422
https://doi.org/10.1016/j.tetlet.2013.09.040
A regioselective high yielding monochloro substitution (chlorohydrin formation) via Mitsunobu reaction is reported. In carbohydrates and sterically hindered non-sugars, only the primary hydroxyl group is chlorinated, whereas in the non-sugar 1,2- and 1,3-alcohols, predominantly the secondary chloride substitution occurs. The versatile methodology provides indirect access to epoxides with the retention of configuration, as against conventional Mitsunobu reaction which generates epoxides with inversion. The methodology was successfully used as a key step in the synthesis of optically active diastereoisomers of the antidepressant drug reboxetine from (R)-2,3-O-cyclohexylidene-D-glyceraldehyde in ∼43% overall yields.
Regioselective monochloro substitution in carbohydrates and non-sugar alcohols via mitsunobu reaction: applications in the synthesis of reboxetine.
Org. Biomol. Chem., 2013, 11, 6195-6207
https://pubs.rsc.org/en/content/articlelanding/2013/ob/c3ob40853a/unauth#!divAbstract
A facile and scalable methodology for the preparation of optically active (3S)‐1‐benzylpyrrolidin‐3‐ol (3), an important drug precursor, is reported. Starting from the naturally occurring alkaloid (−)‐vasicine (1), a major alkaloid of the plant Adhatoda vasica, 3 was obtained in 84% overall yield (Scheme 3).
Natural Vasicine as a Novel Source of Optically Pure 1-Benzyl pyrrolidin-3-ol
Helv.Chim. Acta. 2013, 96, 969-977
https://doi.org/10.1002/hlca.201200307
Bioconversion of sucralose-6-acetate to sucralose, an artificial sweetener has been carried out using Arthrobacter sp. (ABL) and Bacillus subtilis (RRL-1789) strains isolated at IIIM, Jammu, India. Biotransformation of sucralose-6-acetate to sucralose involves use of microbial whole cells, immobilized whole cells and immobilized whole cell bioreactor. Immobilized whole cells packed bed reactor has shown much superior biotransformation process in aqueous system using green technology, where purification of the final product is not required. The final sucralose bioproduct was directly concentrated under vacuum to get white crystalline powder. The immobilized whole cell bioreactor was used for more than three cycles continuously, thus provided much cheaper, less time consuming and easy down streaming process. Moreover, the method does not require any purification steps, which is otherwise requisite for presently available methods for sucralose production, resulting in even lower cost of overall process.
Bioconversion of sucralose-6-acetate to sucralose using immobilized microbial cells
J. Mol. Cat. B: Enzymatic, 2013, 91, 81-86
https://www.sciencedirect.com/science/article/pii/S138111771300057X
The synthesis of both enantiomers of 1,4-benzodioxan-2-carboxylic acid 1, a key synthetic intermediate for the therapeutic agents piperoxan, prosympal, dibozane, and doxazosin was achieved with good yields and high enantioselectivities via the Arthrobacter sp. lipase catalyzed kinetic resolution of ester (±)-17a. The influence of the co-solvents and the immobilization of the lipase upon kinetic resolution demonstrated that immobilized whole cells, in the presence of n-butanol as a co-solvent, resulted in the optimal resolution of the substrate (ee ∼99%, E = 535) at 258 mmol (50 g/L) substrate concentration.
Chemoenzymatic synthesis of piperoxan, prosympal, dibozane, and doxazosin.
Tetrahedron: Asymmetry 2012, 23, 1615-1623.
https://doi.org/10.1016/j.tetasy.2012.10.018
An efficient three-step methodology developed for the preparation of 1,2-amino alcohols. In the first step a rapid coupling between bromoketones and potassium phthalimide in ionic liquid produced α-phthalimido ketones in quantitative yields, which is followed by a facile reduction using NaCNBH3 in acetic acid to give corresponding phthalimido alcohols and finally effecting hydrazinolysis in water at 60 °C to yield biologically important 1,2-amino alcohols.
An efficient preparation of biologically important 1,2-amino alcohols
Synthetic Communications 2013, 43, 505-519
https://doi.org/10.1080/00397911.2011.603876
Enantioenriched cyclic β-amino alcohols, trans-2-aminocyclohexanols (ee, >99%), trans-2-aminocyclopentanols (ee, >99%), trans-1-amino-2-indanols (ee, >99%) and trans-2-amino-1-indanols (ee, ∼98%) were prepared in high yields via an Arthrobacter sp. Lipase/PLAP catalyzed kinetic resolution of racemic phthalimido acetates. The addition of toluene as a co-solvent dramatically improved the hydrolysis and enantioselectivity, whereas for indanols, substrate immobilization on Celite improved the efficacy of the kinetic resolution.
Cyclic trans-β-amino alcohols: preparation and enzymatic kinetic resolution.
Tetrahedron: Asymmetry Volume 22, Issue 24, 31 December 2011, Pages 2134-2143
https://doi.org/10.1016/j.tetasy.2011.11.019
An unusual oleanane triterpene (1) was isolated from aerial parts of Rhododendron campanulatum. The compound had shown prominent antibacterial and immunomodulatory activities. The structure of the compound was determined by spectroscopic data including 1D and 2D NMR spectral analysis.
An unusual bioactive oleanane triterpenoid from Rhododendron campanulatum D. Don
Chinese Chemical Letters 2011, 22, 575–579
https://www.sciencedirect.com/science/article/pii/S1001841710004808
In the presence of NBS and a catalytic amount of a Lewis acid, 2,3-unsaturated allyl glycosides [6-(allyloxy)-3,6-dihydro-2-(hydroxymethyl)-2H-pyran-3-ol] have been successfully used as versatile glycosyl donors for the stereoselective α-glycosylation of a variety of alcohols comprising sensitive functions such as acetonide, keto, nitro, and ester in 50−90% yields. The methodology offers an equally facile alternative to 4-pentenyl replacement in unsaturated sugars.
2,3-Unsaturated Allyl Glycosides as Glycosyl Donors for Selective α-Glycosylation
J. Org. Chem. 2011,  76, 9, 3506-3510
https://pubs.acs.org/doi/abs/10.1021/jo102333x
National Council for Scientific and Technological Development, Brazil
National Council for Scientific and Technological Development (CNPq) postdoctoral fellowship
Scientific and Technological Research Council, Turkey
Scientific and Technological Research Council of Turkey (TUBITAK) postdoctoral fellowship, Turkey,
Council of Scientific and Industrial Research (CSIR)
Senior Research Fellowship (CSIR-SRF)
Council of Scientific and Industrial Research (CSIR)
Junior Research Fellowship (CSIR-JRF)
IL&FS Education English Language course
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This award aims to characterize the chemical structures of key small-molecule signals that nematodes use to control their development. The small-molecule signals from representative nematode species can be identified using comparative metabolomics between wild-type worms and biosynthetic mutants. The relevant compounds are then be purified using mass-guided fractionation, and their structures characterized using NMR spectroscopy. Comparison of the chemical structures and biosynthetic gene sequences from different nematode species enables the roles of specific enzymatic domains to be mapped across nematode evolution. To study the activities of specific enzymatic domains, this study uses a multidisciplinary approach incorporating tools from biochemistry, organic chemistry, structural biology, analytical chemistry, and nematode genetics. The results of this award are expected to shed light on how nematodes control their life cycles and the development of novel methods to reduce the survival of parasitic nematodes. The educational portion of this project increases retention of undergraduate students in science fields by developing a discovery-based (rather than cookbook style) laboratory course in natural product identification. The proposed course extends the research opportunities for undergraduate and high school students and may lead to the discovery of novel bacterial/fungal metabolites with anti-nematode activities.
A multidisciplinary approach to the investigation of secondary metabolism in nematodes
Abstract

The proposed research program will develop a comprehensive understanding of the chemical structures, biosynthesis, and mechanism of the secondary metabolites used by the nematode Caenorhabditis elegans to control its development and physiology. We will focus on two important types of chemical signals: (1) The dauer pheromone, which C. elegans uses to induce development of the stress-resistant, dauer larval stage at high population densities. (2) A complex hybrid polyketide/ nonribosomal peptide (PK/NRP), which we have recently identified and shown is important for starvation-induced larval arrest. The dauer pheromone consists of several derivatives of the 3,6-dideoxy-L-sugar ascarylose, with different fatty acid-derived side chains. These ascarosides target G protein-coupled receptors in chemosensory neurons and downregulate the insulin and TGF? pathways, which regulate dauer formation, metabolism, and lifespan in C. elegans. 
In Aim 1 of this proposal, we will use a multi-disciplinary approach, including metabolomics, in vitro enzyme assays, organic synthesis of biosynthetic intermediates, and RNAi-based screens, to provide a general framework for ascaroside biosynthesis and its regulation. Our preliminary results, which show that secondary metabolism in C. elegans is closely tied to primary metabolism, have uncovered new, surprising roles for primary metabolic enzymes in ascaroside biosynthesis...

Many nematode (roundworm) species are parasites of humans, livestock, and crops, infecting one-third of humans world-wide and causing billions of dollars in agricultural losses. An understanding of the chemical signals used by nematodes to control their development will provide new strategies and chemical treatments to interfere with the life cycles of parasitic species and reduce their survival.
Small-molecule signals controlling nematode development
Synthesis of zygosporamide analogues by consecutive Ugi reactions
Synthesis of substituted isoxazoline-N-oxides, isoxazoles and dihydroisoxazoles by one pot cascade green reaction
Synthesis of Chiral Amino Alcohols and Oxa- /Aza-Heterocyclic Intermediates of Bioactive Molecules
(R)-2,3-Cyclohexylideneglyceraldehyde, a chiral pool synthon for the synthesis of bioactive molecules.
Extraction of vasicine from the leaves of Adhatoda vasica and its modification into  HDAC inhibitors, antidiabetic and antihypertensive agents
Exploitation of India’s rich microbial diversity’ (NWP 006)
Development of novel target based anticancer therapeutics” (CSIR Supra Institutional Project: SIP 0027)
Science and Technology
6th International conference on multicomponent reactions and related chemistry
I was involved in the organization and management of the 6th international conference on multicomponent reactions and related chemistry, Brasilia, Brazil
Organizer Commitee Member
Science and Technology
Frontiers in Medicinal Chemistry and Drug Discovery
Editorial Board Member
Science and Technology
Journal of Pharmacology and Therapeutics Forecast
Editorial Board Member
International Research Journal of Chemistry and Chemical Sciences
Editorial Board Member
Science and Technology
Chirality Journal
Reviewer
Science and Technology
International Journal of Chemistry
Reviewer
Science and Technology
Current Medicinal Chemistry
https://www.linkedin.com/company/current-medicinal-chemistry
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Microbial Pathogenesis
Reviewer
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Current Bioactive Compounds
Reviewer
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Glycobiology Insights
Reviewer
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Journal of Materials Science and Chemical Engineering
Reviewer
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Advances in Chemical Engineering and Science
Reviewer
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Asian Journal of Organic & Medicinal Chemistry
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Green and Sustainable Chemistry
Reviewer
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Studies in Natural Products Chemistry
Reviewer
Science and Technology
International Research Journal of Chemistry
Reviewer
Science and Technology
Narodowe Centrum Nauki - NCN
Grant Evaluator
Science and Technology
General Chemistry
Editorial Board Member
Science and Technology
Acta Chimica Slovenica
Reviewer
Science and Technology
International Journal of Chemistry
Editorial Board
https://www.linkedin.com/in/kagna-sampson-69a56323
Louisville, KY
kagna Sampson
Lecturer of chemistry
https://www.linkedin.com/in/yanbo-yu-75017041
St Louis, MO
Yanbo Yu
Postdoc Research Associate at Washington University School of Medicine in St. Louis
https://www.linkedin.com/in/surina-borjigin-59a36054
United States
Surina Borjigin
--
https://www.linkedin.com/in/andrew-haddad-8b110037
Berkeley, CA
Andrew Haddad
Research Scientist at Berkeley Lab
https://www.linkedin.com/in/sara-biladeau-m-d-ph-d-518a8b23
Louisville, KY
Sara Biladeau, M.D., Ph.D.
Resident Physician - Anesthesiology at University of Louisville
https://www.linkedin.com/in/arieltocher
United States
Ariel Tocher
Senior Scientist at Merck
https://www.linkedin.com/in/tianyu-huang-bb42b8158
St Louis, MO
Tianyu Huang
Washington University School of Medicine in St. Louis - Postdoctoral Research Associate
https://www.linkedin.com/in/hamzeh-telfah-66172196
Columbus, OH
Hamzeh Telfah
PhD
https://www.linkedin.com/in/gshang
Rahway, NJ
Gao Shang
Principal Scientist, External Enabling Technologies Lead, External Capabilities, PR&D at Merck
https://www.linkedin.com/in/katherine-sellers
Greater Boston
Katherine Sellers
Head of Discovery Metabolism
https://www.linkedin.com/in/msaleheen
Des Plaines, IL
Mohammad Saleheen
R&D Engineer/Scientist II, Honeywell
https://www.linkedin.com/in/arjun-kumar-thapa-38616047
Louisville, KY
Arjun Kumar Thapa
Battery Scientist at Conn Center for Renewable Energy Research, UofL
https://www.linkedin.com/in/khoa-nguyen-996a2b98
Danbury, CT
Khoa Nguyen
Senior Scientist - Boehringer Ingelheim Pharmaceutical Inc.
https://www.linkedin.com/in/sahar-pishgar-a21549aa
Ann Arbor, MI
Sahar Pishgar
Post Doctoral Research Fellow at University of Michigan
https://www.linkedin.com/in/xue-yang-155077109
Worcester, MA
Xue Yang
Senior Scientist I at AbbVie
https://www.linkedin.com/in/yu-bai-356a5526
Wilmington, DE
Yu Bai
Senior Research Investigator at Incyte
https://www.linkedin.com/in/gang-wang-ph-d-35b55777
New York City Metropolitan Area
Gang Wang, Ph.D.
Principal Scientist I at Schrödinger
https://www.linkedin.com/in/lin-ju-3a9929103
Greater Boston
Lin Ju
Research Investigator at DuPont
https://www.linkedin.com/in/rgurusin
Columbia, MO
RANIL GURUSINGHE, PhD
Research Scientist at the University of Missouri-Columbia
Cihangir Tanyeli
      
          



            
              
        
              
  

    
        It is a pleasure to write an open testimonial in support of one of the best post doctoral fellow, Abdul ROUF. I have known him since 2014 when he joined to my research group. During his stay, he supported by The Scientific and Technological Research Council of Turkey (TUBITAK) as a result of long evaluation term and chosen among almost 50 candidates. Abdul is capable of initiating and planning research projects and preparing successful applications for research grants as he did in his application. 
His performance as a researcher was extraordinary. Abdul’s enthusiasm and disciplined approach to many problems enabled him to get most out of his position among the other post doctoral fellows. He was completely independent during his work and being a good experimentalist with a mature outlook. He was frequently called upon to give help and advice to other graduate students in my research laboratories. This is of course also a reflection of his broader interests in Chemistry. During his stay, he accomplished the full project proposed to TUBITAK. In this project, he developed a green chemistry approach to synthesize wide range of isoxazole-N-oxides via one pot cascade type reactions. He also well documented review article regarding Bioactive Thiazole and Benzothiazole Derivatives and accepted by European Journal of Medicinal Chemistry. 
 Praveen Kumar, PhD
      
          



            
              
        
              
  

    
        I know Abdul Rouf Dar since 2009 and have worked with him during my PhD 2009 to 2013. He is very knowledgeable, professional, and great to work with. He has been the major contributor to many projects and considered as an asset to the project teams. He consistently delivered high quality data and exceeded expectations. He has a great interpersonal skill and never stopped to assist his co-workers at every opportunity. I highly recommend him to any successful organization.
https://in.linkedin.com/in/bilal-a-dar-52563a19
Ganderbal
Bilal A Dar
Diagnostic Radiographer SKIMS soura srinagar,J&K Regional Coordinatorte ISRT
https://ca.linkedin.com/in/a-dar-9b158614a
Canada
A Dar
Managing Director
https://uk.linkedin.com/in/ahmad-waqas-dar-4b8bb0166
United Kingdom
Ahmad Waqas Dar
MSBA Candidate @ UoS Business School | NUST'21 | Data Analytics
https://mx.linkedin.com/in/vamosadar
Toluca, MEX
Vamos a Dar
Coordinación General en Fundación Vamos a Dar
Medicinal Chemistry: The Senior Level Chemists Professional Group
https://media-exp1.licdn.com/dms/image/C5107AQEmDZV9vpopVQ/group-logo_image-shrink_200x200/0/1631403168808?e=1647687600&v=beta&t=6h2XhRpvezrpmlyBHm2i0TIiozMWOmIXh9f4jML5DjQ
https://www.linkedin.com/groups/2526205
NJ Bio Pharma Networking Group (NJBPNG)
https://media-exp1.licdn.com/dms/image/C5607AQGJxb_lh773UA/group-logo_image-shrink_200x200/0/1631427902289?e=1647687600&v=beta&t=2IDywmW8ZsYF4DG_fpJ2J9pInc2tNHMmzlEbLec2toE
https://www.linkedin.com/groups/4268020
UF Postdocs
https://static-exp1.licdn.com/sc/h/4h1ldzvvebtszyx75ve7dst1v
https://www.linkedin.com/groups/4479251