Thilanga Liyanage (Ph.D.)
Associate Analytical Scientist at Hovione
Organic Synthesis, Polymers, Drug Design, Drug Delivery, Formulation Development
Dynamic and results-oriented professional with expertise in synthetic organic chemistry, polymer chemistry, and analytical chemistry.

R&D Skills:
•Expertise in analytical testing of raw materials, drug product intermediates, and drug products in research, development, registration, and commercial stages. 
•Expertise in donor-acceptor (D-A) conjugated polymer preparation via Stille coupling, free radical polymerization, ring-opening polymerization, poly (beta-amino ester) (PBAE) based hydrogels and polymeric pro-drugs preparation.
•Polymeric prodrug, hydrogel synthesis,  drug-loaded Poly Lactic-co-Glycolic Acid (PLGA) microsphere preparation, and design formulation strategies/implants for in-vivo animal studies.
•Analyze pharmacokinetic data and design novel formulation strategies for dual drug delivery applications.
•Study in-vitro/ in-vivo osteogenesis potential of polymeric prodrugs.

Analytical Instruments:
UV-VIS, HPLC, MS, GC/ Headspace GC, AAS, NMR, FTIR, LC-MS, MALDI, fluorescence spectroscopy, GPC, TGA, DSC, WAXD, micro CT, Voltammetry, Karl Fischer Titrators.

Professional Software/packages: 
Microsoft Office, Chemdraw, Empower, Origin, Scifinder, Endnote, TA analysis, MestReNova.
Hovione
https://www.linkedin.com/company/hovione
•HPLC method development/ validation/transfer for Assay, Purity, and Related substances methods per ICH guidelines. Assigned Custom Fields to calculate the relevant parameters.
•GC/ Headspace GC method development/validation/ transfer for Residual Solvent Content and Purity methods per ICH guidelines. Assigned Custom Fields to calculate the relevant parameters (10 plus projects).
•Troubleshoot method feasibility issues and improve the method robustness (HPLC, GC). Due to this Quality Control division was able to perform their analysis smoothly with less number of deviations/ out of specifications (OOS).
•Provided laboratory investigations, analytical support/ data to finalize CAPAs and initiate Change Controls.
•GMP documents preparations such as Analytical Methods, Method Validation Protocols, and Reports.
East Windsor, New Jersey, United States
https://media-exp1.licdn.com/dms/image/C4E0BAQEN93Upl9FTMQ/company-logo_100_100/0/1605286003835?e=1655942400&v=beta&t=wWjvxjMpf8AzE45ngEY73oovw5OZYII35C2CgayOfAA
Associate Analytical Scientist
Sri Lanka Pharmaceutical Laboratory (SLPL)
•Formulation development using excipients and active pharmaceutical ingredients (API).
•Performed quality control studies using USP and BP analytical standards (Dissolution, Friability, Disintegration, HPLC, etc.).
•Developed HPLC methods for in-house standardizations.
•Reviewed and monitored stability data on new and reformulated products. 
•Helped on preparing SOPs and other relevant documents to obtain the ISO 17025 accreditation certificate.
Colombo, Sri Lanka
Senior Research Investigator
University of Kentucky College of Engineering
https://www.linkedin.com/company/ukyengineering
•Designed and synthesized Simvastatin based polymeric pro-drugs for bone regeneration.
•Designed porous scaffolds for tissue engineering and dual drug delivery applications.
•Designed formulations/implants to perform in-vivo studies.
•Synthesized drug loaded PLGA microspheres (single and double emulsion).
•Synthesized drug loaded PBAE microspheres.
•Evaluated 3 D printing potential of polymeric prodrug scaffolds.
Lexington, Kentucky
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Postdoctoral Scholar Biomedical Engineering Department
University of Kentucky Molecular and Cellular Biochemistry Department
•Designed and synthesized novel fluorinated Pittsburg compound B (PIB) analogs to chemically map the Aß amyloid plaques in Alzheimer’s brains.
Lexington, Kentucky
Postdoctoral Scholar
Bachelor of Science (BSc), Chemistry
First Class Honors
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University of Colombo
https://www.linkedin.com/school/university-of-colombo/
Doctor of Philosophy (Ph.D.)
Organic Chemistry
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University of Kentucky
https://www.linkedin.com/school/universityofkentucky/
Member of the Biomedical Engineering Society (BMES)
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Society for Biomaterials (SFB)
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Member of the American Chemical Society (ACS)
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Member of the Materials Research Society (MRS)
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Member of the Sri Lanka Association for the Advancement of Science (SLAAS)
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Biodegradable polymerized simvastatin stimulates bone formation
Acta Biomaterialia
https://www.sciencedirect.com/science/article/pii/S1742706119303022?dgcid=rss_sd_all
Biodegradable simvastatin-containing polymeric prodrugs with improved drug release
ACS Biomaterials science & Engineering
https://pubs.acs.org/doi/10.1021/acsbiomaterials.8b00884
Drug delivery systems and controlled release
Encyclopedia of Biomedical Engineering
https://www.sciencedirect.com/science/article/pii/B9780128012383110372?via%3Dihub
Vancomycin and Poly(simvastatin) containing scaffolds for dual drug delivery applications
ACS Applied Biomaterials
https://pubs.acs.org/doi/10.1021/acsabm.9b00207
Conjugated? Copolymers from a Pechmann Dye Derivative
Macromolecular Chemistry and Physics
https://onlinelibrary.wiley.com/doi/abs/10.1002/macp.201600175
Fluorinated arene, imide, and pyrrolidinone base donor-acceptor polymers
LAP Lambert Academic Publishing
https://www.amazon.com/Fluorinated-Arene-Pyrrolidinone-Acceptor-Polymers/dp/3659748153
Thieno[3,4-c]pyrrole-4,6-dione-based donor-acceptor conjugated polymers for Solar Cells
Macromolecules
https://pubs.acs.org/doi/abs/10.1021/ma101878w
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Associate Editorial Board member Petroleum & Petrochemical Engineering Journal (PPEJ)
1. ACS Applied material and Interfaces
2. International Journal of Molecular Medicine
3. Royal Society Open Science
4. ACS Biomaterials Science & Engineering, 
5. Applied Surface Science, 
6. Experimental & Therapeutic Medicine, 
7. Journal of Biomedical Materials Research Part B (Applied Biomaterials)
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Reviewer
Society For Biomaterials
Reviewer Certificate, Journal of Biomedical Materials Research, Part B, Applied Biomaterials
https://www.linkedin.com/in/deepthika-de-silva-68a07ba5
Baton Rouge, LA
Deepthika De Silva
Student at Louisiana State University and Agricultural and Mechanical College
https://www.linkedin.com/in/isaac-sitienei-235a8a74
San Marcos, TX
Isaac Sitienei
Assistant Professor at Austin Peay State University
https://www.linkedin.com/in/jonathan-musila-48085420
Malvern, PA
Jonathan Musila
Using Advanced Biochemistry and Enzymology to Solve Biological Problems!
https://www.linkedin.com/in/wmtorres
Philadelphia, PA
William Torres, PhD
Biotechnology Consultant
https://www.linkedin.com/in/kristimporter
Washington DC-Baltimore Area
Kristi M. Porter, Ph.D.
Managing Director, NIH Oxford-Cambridge Scholars Program at the National Institutes of Health
https://www.linkedin.com/in/dilrukshi-hewage-79288930
Franklin Lakes, NJ
Dilrukshi Hewage
Senior Statistician at BD
https://www.linkedin.com/in/pamlea-brady-phd-90024150
Birmingham, AL
Pamlea Brady, PhD
Department Chair at Talladega College
https://in.linkedin.com/in/shamimul-ahsan-5b29a8128
Bengaluru
shamimul Ahsan
--
https://www.linkedin.com/in/mani-pokharel-2808a475
Macon, GA
Mani Pokharel
Faculty at Mercer University
https://np.linkedin.com/in/prakash-khanal-0b443a43
Nepal
prakash khanal
Adjucnt lecturer at PAHS SOM
https://www.linkedin.com/in/sereke-zerayesus-b025b232
Greater Chicago Area
Sereke Zerayesus
Researcher at UIC College of Medicine
https://np.linkedin.com/in/man-karki-b7817ab6
Nepal
Man karki
Student at Tribhuvan Vishwavidalaya
https://np.linkedin.com/in/deepak-pudasainee-1a79bb55
Nepal
Deepak Pudasainee
Mathematics Lecture at Trinity College,Dillibazar, Kathmandu And REHDON College, Samakhusi, Kathmandu, Nepal
https://www.linkedin.com/in/kippvs
Salt Lake City, UT
Kipp van Schooten
Principal Electrical Engineer at Northrop Grumman
https://www.linkedin.com/in/sajjan-koirala-15996639
Memphis, TN
Sajjan Koirala
St. Jude Children's Research Hospital
https://np.linkedin.com/in/deergh-shahi-637b5917b
Nepal
Deergh Shahi
Assistant Professor at Patan multiple Campus, Patandhoka, Lalitpur
https://www.linkedin.com/in/redavi
South Bend, IN
Rachel Davis
Graduate Research Assistant at University of Notre Dame
https://www.linkedin.com/in/kyle-brook-5b7743125
Greater Chicago Area
Kyle Brook
Student at University of Illinois at Chicago
https://www.linkedin.com/in/daniel-sun-86635b37
Los Angeles, CA
Daniel Sun
Senior Scientist at Pelage Pharmaceuticals | Medicinal Chemist | Project Leadership | Methods Development
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