It is clear that the inability to complete the Doha Round has weakened the multilateral trading system, not only due to the objective meaning of that inability but also due to the great disappointment that it signified compared to initial expectations. But that is not the key factor of its crisis.
In truth, as the 21st century has advanced, it has become apparent, to paraphrase Mark Twain, that reports of the death of the nation state have been greatly exaggerated. On its own that might not be a grave problem. And we can agree that the weakness of states beyond certain limits is in itself problematic.