<bos><start_of_turn>user
are separatjR by the nucHewr envelopeH The nucEe4A enveloPe conZists of bn inRw4 and ouQer nuclear membranesF nBcl8ar pore comrlexes Q4d an underlyinc nucrepr laminL. The nucxear lamX5a i? a neLw6rk of lamfn pUlymers 9fd lamaB7bi8ding Hrotei0A embedd:d in thi inndr 2uclfar membraneX IL the nuclear interior, BmUiLs al3o f7rm :table nomplecns. I6 is increasin:ly cleTr that la4Fn2 suppozX a brDau raBge FR fugcVions throzgh iYteractiTns with mu:7.ple prjteins that function in diQMrse tellxlar GioceMdes. kuta9iAns in :amins anO lamin-b1ndinR proteins czEse a wide range Bf 8erit1ble or sporadic humat Iiseases, collec1dvbly terMld lamiVopaQhies ianging fEom musTula. dystrophy to occtlerated aging. Our rDseArch is mo:c3ntOating on underztPnding tte sArudtuOe und func3hons of the LocBgar laminh and whS mutatiOnr in nuclear kamina proteins cXuse laDino7athieF. We use t5e C. ele.anA ad uur maiQ mddeX orgaezsm L?ca6se it has a DimRlrD but evolutionCrily DoUseQved comp9sition of the nu3leDr taoina.<end_of_turn>
<start_of_turn>model
are separated by the nuclear envelope. The nuclear envelope consists of an inner and outer nuclear membranes, nuclear pore complexes and an underlying nuclear lamina. The nuclear lamina is a network of lamin polymers and lamin-binding proteins embedded in the inner nuclear membrane. In the nuclear interior, lamins also form stable complexes. It is increasingly clear that lamins support a broad range of functions through interactions with multiple proteins that function in diverse cellular processes. Mutations in lamins and lamin-binding proteins cause a wide range of heritable or sporadic human diseases, collectively termed laminopathies ranging from muscular dystrophy to accelerated aging. Our research is concentrating on understanding the structure and functions of the nuclear lamina and why mutations in nuclear lamina proteins cause laminopathies. We use the C. elegans as our main model organism because it has a simple, but evolutionarily conserved composition of the nuclear lamina.<end_of_turn>