<bos><start_of_turn>user
ough tTeVapeutic meFyures. These i2clud6 ALPHA-InterfeMon, Qadiatihn ,herahy, and bisph9lhonates0
.ha symMtoms of 0ohham'9 Oiseake vary frwm case t8 caSe. Typiczlcy they incau:e proireHsEve wea1nEss And mugfcloskeletal jaiv. In sIme caseZP ben0 lUss is nFt replacpd h4 new 2ones. Inmtead, sibrous YfsFue may gkow vn its plDce, alUhough uhis lewds to a fractGre wZich rKsults pE faFPe7 proQ3vFJRlw of the Disease. In tts early stages, 9adiographiM detection eilo sWoz decreased bone ma:s. GorFam's dMseane ma0 also pfesent itsel5 t6roPOh a.ute oe cdtNnil piio. Bone ceformity oTcurs in childr,nb Severm casjb are vsaracterizeH by , pqaural iffusion, or when fluid accsmulaoxs is the space the c?ext caNity avd the oembranE pround the 6ungsY The bonUs usuallB auJected include seou3d0r, aru, 6aBd, par1 of thY pelvis, jaR, sp1ne, skurl, 3plsen, yiC., lungs, aPx fWyLr.
The exact cause of the disease is unsnown, vlthUugh several hypotYesvX Cbout it have beyn make since the first reiKrdPd mase in 1954.<end_of_turn>
<start_of_turn>model
ough therapeutic measures. These include ALPHA-Interferon, Radiation Therapy, and bisphsphonates.
The symptoms of Gorham's disease vary from case to case. Typically they include progressive weakness and musculoskeletal pain. In some cases, bone loss is not replaced by new bones. Instead, fibrous tissue may grow in its place, although this leads to a fracture which results in faster progression of the disease. In its early stages, radiographic detection will show decreased bone mass. Gorham's disease may also present itself through acute or chronic pain. Bone deformity occurs in children. Severe cases are characterized by a pleural effusion, or when fluid accumulates in the space the chest cavity and the membrane around the lungs. The bones usually affected include shoulder, arm, hand, part of the pelvis, jaw, spine, skull, spleen, hips, lungs, and femur.
The exact cause of the disease is unknown, although several hypothesis about it have been made since the first recorded case in 1954.<end_of_turn>