That  which  nezfc  follows,  after  the  increased  afilux  of  blood,  is  the
production  of  thematerial  that  is  to  be  organised  into  granulations. This
IS  added  to,  or  perhaps  displaces,  the  glazing  that  already  exists  upon
some  surfaces  ;  and  where  none  such  exists,  as  on  fat  or  bone,  the  new
material  forms  on  the  bare  surface  of  the  wound. No  account  of  the
appearance  presented  by  the  reparative  material,  so  far  as  it  is  visible
to  the  naked  eye,  can  be  better  than  Mr. Hunter's  (iii. 491). 'I  have
often  been  able,'  he  says,  'to  trace  the  growth  and  vascularity  of  this
new  substance. I  have  seen  upon  a  sore  a  white  substance,  exactly
similar,  in  every  visible  respect,  to  coagulating  lymph. I  have  not
attempted  to  wipe  it  off,  and  the  next  day  of  dressing  I  have  found  this
very  substance  vascular ;  for  by  wiping  or  touching  it  with  a  probe  it
has  bled  freely. I  have  observed  the  same  appearance  on  the  surface
of  a  bone  that  was  laid  bare. I  once  scraped  off  some  of  the  external
surface  of  a  bone  of  the  foot,  to  see  if  the  surface  would  grannlate. I
remarked  the  following  day  that  the  surface  of  the  bone  was  covered
with  a  whitish  substance,  having  a  tinge  of  blue ;  when  I  passed  my
probe  into  it  I  did  not  feel  the  bone  bare,  but  only  its  resistance. I
conceived  this  substance  to  be  coagulating  lymph  thrown  out  from
inflammation,  and  that  it  would  be  forced  off  when  suppuration  came
on  ;  but  on  the  succeeding  .day  I  found  it  vascular,  and  appearing  like
healthy  granulations.'

To  this  description  little  can  be  added  more  than  the  microscope
has  shovm. In  the  minute  structure  of  granulations,  or  at  least  of  such
growths  of  new  substance  as  present  all  the  characters  that  we  imply
by  that  term — the  bright  ruddy  texture,  soft  and  elastic,  the  uniformly
granulated  free  surface,  the  succulency  ^.nd  abundant  supply  of  blood
— in  these  we  may  discern  two  varieties. In  subcutaneous  injuries  or
diseases  granulations  sometimes  form,  which  develop  thepiaelves  into
connective  tissue  through  nucleated  blastema  or  protoplasm. 