Survival Analysis of Young Triple-Negative Breast Cancer Patients
M. Mehdi Owrang O Fariba Jafari Horestani Ginger Schwarz
Breast cancer prognosis is crucial for effective treatment, with the disease
more common in women over 40 years old but rare under 40 years old, where less
than 5 percent of cases occur in the U.S. Studies indicate a worse prognosis in
younger women, which varies by ethnicity. Breast cancers are classified based
on receptors like estrogen, progesterone, and HER2. Triple-negative breast
cancer (TNBC), lacking these receptors, accounts for about 15 percent of cases
and is more prevalent in younger patients, often resulting in poorer outcomes.
Nevertheless, the impact of age on TNBC prognosis remains unclear. Factors like
age, race, tumor grade, size, and lymph node status are studied for their role
in TNBC's clinical outcomes, but current research is inconclusive about
age-related differences. This study uses SEER data set to examine the influence
of younger age on survivability in TNBC patients, aiming to determine if age is
a significant prognostic factor. Our experimental results on SEER dataset
confirm the existing research reports that TNBC patients have worse prognosis
compared to non-TNBC based on age. Our main goal was to investigate whether
younger age has any significance on the survivability of TNBC patients.
Experimental results do not show that younger age has any significance on the
prognosis and survival rate of the TNBC patients