Regression-Based Analysis of Multimodal Single-Cell Data Integration
  Strategies
Bhavya Mehta Nirmit Deliwala Madhav Chandane
Multimodal single-cell technologies enable the simultaneous collection of
diverse data types from individual cells, enhancing our understanding of
cellular states. However, the integration of these datatypes and modeling the
interrelationships between modalities presents substantial computational and
analytical challenges in disease biomarker detection and drug discovery.
Established practices rely on isolated methodologies to investigate individual
molecular aspects separately, often resulting in inaccurate analyses. To
address these obstacles, distinct Machine Learning Techniques are leveraged,
each of its own kind to model the co-variation of DNA to RNA, and finally to
surface proteins in single cells during hematopoietic stem cell development,
which simplifies understanding of underlying cellular mechanisms and immune
responses. Experiments conducted on a curated subset of a 300,000-cell time
course dataset, highlights the exceptional performance of Echo State Networks,
boasting a remarkable state-of-the-art correlation score of 0.94 and 0.895 on
Multi-omic and CiteSeq datasets. Beyond the confines of this study, these
findings hold promise for advancing comprehension of cellular differentiation
and function, leveraging the potential of Machine Learning.