CRC-ICM: Colorectal Cancer Immune Cell Markers Pattern Dataset
Zahra Mokhtari Elham Amjadi Hamidreza Bolhasani Zahra Faghih AmirReza Dehghanian Marzieh Rezaei
Colorectal Cancer (CRC) is the second most common cause of cancer death in
the world, ad can be identified by the location of the primary tumor in the
large intestine: right and left colon, and rectum. Based on the location, CRC
shows differences in chromosomal and molecular characteristics, microbiomes
incidence, pathogenesis, and outcome. It has been shown that tumors on left and
right sides also have different immune landscape, so the prognosis may be
different based on the primary tumor locations. It is widely accepted that
immune components of the tumor microenvironment (TME) plays a critical role in
tumor development. One of the critical regulatory molecules in the TME is
immune checkpoints that as the gatekeepers of immune responses regulate the
infiltrated immune cell functions. Inhibitory immune checkpoints such as PD-1,
Tim3, and LAG3, as the main mechanism of immune suppression in TME
overexpressed and result in further development of the tumor. The images of
this dataset have been taken from colon tissues of patients with CRC, stained
with specific antibodies for CD3, CD8, CD45RO, PD-1, LAG3 and Tim3. The name of
this dataset is CRC-ICM and contains 1756 images related to 136 patients. The
initial version of CRC-ICM is published on Elsevier Mendeley dataset portal,
and the latest version is accessible via: https://databiox.com