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30941577 | Horizontally Aggregation of Monolayer Reduced Graphene Oxide Under Deep UV Irradiation in Solution. | Graphene has been widely used in novel optoelectronic devices in decades. Nowadays, fabrication of large size monolayer graphene with spectral selectivity is highly demanded. Here, we report a simple method for synthesizing large size monolayer graphene with chemical functionalized groups in solution. The few layer nano-graphene can be exfoliated into monolayer nano-graphene under short time UV irradiation in protic solution. The exfoliated monolayer nano-graphene could experience deoxygenation during long time UV exposure. At the same time, the edge of nano-graphene could be activated under deep UV exposure and small size nano-graphene sheets further aggregate horizontally in solution. The size of aggregated rGO increase from 40 nm to a maximum of 1 μm. This approach could be one promising cheap method for synthesizing large size monolayer reduced graphene oxide in the future. | 2019 Apr 2 | Nanoscale research letters | No DOI | [
{
"LastName": "He",
"FirstName": "Xiaoxiao",
"Affiliation": "State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, 200062, China."
},
{
"LastName": "Zhang",
"FirstName": "Sanjun",
"Affiliation": "State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, 200062, China."
},
{
"LastName": "Pan",
"FirstName": "Haifeng",
"Affiliation": "State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, 200062, China."
},
{
"LastName": "Chen",
"FirstName": "Jinquan",
"Affiliation": "State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, 200062, China. [email protected]."
},
{
"LastName": "Xu",
"FirstName": "Jianhua",
"Affiliation": "State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, 200062, China. [email protected]."
}
] | No |
38039629 | Effect of using hypotension prediction index versus conventional goal-directed haemodynamic management to reduce intraoperative hypotension in non-cardiac surgery: A randomised controlled trial. | It remains unclear whether it is the hypotension prediction index itself or goal-directed haemodynamic therapy that mitigates intraoperative hypotension. A single centre randomised controlled trial. Sapporo Medical University Hospital. A total of 64 adults patients undergoing major non-cardiac surgery under general anaesthesia. Patients were randomly assigned to either group receiving conventional goal-directed therapy (FloTrac group) or combination of the hypotension prediction index and conventional goal-directed therapy (HPI group). To investigate the independent utility of the index, the peak rates of arterial pressure and dynamic arterial elastance were not included in the treatment algorithm for the HPI group. The primary outcome was the time-weighted average of the areas under the threshold. Secondary outcomes were area under the threshold, the number of hypotension events, total duration of hypotension events, mean mean arterial pressure during the hypotension period, number of hypotension events with mean arterial pressure < 50 mmHg, amounts of fluids, blood products, blood loss, and urine output, frequency and amount of vasoactive agents, concentration of haemoglobin during the monitoring period, and 30-day mortality. The time-weighted average of the area below the threshold was lower in the HPI group than in the control group; 0.19 mmHg (interquartile range, 0.06-0.80 mmHg) vs. 0.66 mmHg (0.28-1.67 mmHg), with a median difference of -0.41 mmHg (95% confidence interval, -0.69 to -0.10 mmHg), p = 0.005. Norepinephrine was administered to 12 (40%) and 5 (17%) patients in the HPI and FloTrac groups, respectively (p = 0.045). No significant differences were observed in the volumes of fluid and blood products between the study groups. The current randomised controlled trial results suggest that using the hypotension prediction index independently lowered the cumulative amount of intraoperative hypotension during major non-cardiac surgery. | 2024 May | Journal of clinical anesthesia | No DOI | [
{
"LastName": "Yoshikawa",
"FirstName": "Yusuke",
"Affiliation": "Department of Anaesthesiology, Sapporo Medical University School of Medicine, South1 West16 291, Chuoku, Sapporo 060-8543, Japan. Electronic address: [email protected]."
},
{
"LastName": "Maeda",
"FirstName": "Makishi",
"Affiliation": "Department of Anaesthesiology, Sapporo Medical University School of Medicine, South1 West16 291, Chuoku, Sapporo 060-8543, Japan."
},
{
"LastName": "Kunigo",
"FirstName": "Tatsuya",
"Affiliation": "Department of Anaesthesiology, Sapporo Medical University School of Medicine, South1 West16 291, Chuoku, Sapporo 060-8543, Japan."
},
{
"LastName": "Sato",
"FirstName": "Tomoe",
"Affiliation": "Department of Anaesthesiology, Sapporo Medical University School of Medicine, South1 West16 291, Chuoku, Sapporo 060-8543, Japan."
},
{
"LastName": "Takahashi",
"FirstName": "Kanako",
"Affiliation": "Department of Anaesthesiology, Sapporo Medical University School of Medicine, South1 West16 291, Chuoku, Sapporo 060-8543, Japan."
},
{
"LastName": "Ohno",
"FirstName": "Sho",
"Affiliation": "Department of Anaesthesiology, Sapporo Medical University School of Medicine, South1 West16 291, Chuoku, Sapporo 060-8543, Japan."
},
{
"LastName": "Hirahata",
"FirstName": "Tomoki",
"Affiliation": "Department of Anaesthesiology, Sapporo Medical University School of Medicine, South1 West16 291, Chuoku, Sapporo 060-8543, Japan."
},
{
"LastName": "Yamakage",
"FirstName": "Michiaki",
"Affiliation": "Department of Anaesthesiology, Sapporo Medical University School of Medicine, South1 West16 291, Chuoku, Sapporo 060-8543, Japan."
}
] | No |
35211089 | Iron Homeostasis and Hepcidin Concentration in Patients With Acromegaly. | Hepcidin is a protein responsible for maintaining iron (Fe) homeostasis. Data regarding the role of hepcidin in the pathomechanism of Fe balance disturbances associated with acromegaly (AG) are scarce. The aim of the study was to assess the impact of alterations in complete blood count parameters, Fe homeostasis, gonadal status and GH/IGF-1 on the level of hepcidin in AG patients. The study evaluated the differences in hepcidin concentration and iron homeostasis between patients newly diagnosed with AG in comparison to healthy control subjects (CS). We prospectively enrolled 25 adult patients newly diagnosed with AG and 25 healthy volunteers who served as CS. The level of hepcidin was measured using the Hepcidin 25 (bioactive) hs ELISA, which is a highly sensitive enzyme immunoassay for the quantitative in vitro diagnostic measurement (DRG Instruments GmbH, Germany). The median of hepcidin concentration in the serum of patients with AG was significantly lower 9.8 (6.2-18.2) ng/ml as compared to CS 21.3 (14.3-34.0) ng/ml (p = 0.003). In the AG group, a statistically significant negative correlation between hepcidin and IGF-1 (rho = -0.441) was observed. Our study demonstrated a decreased hepcidin level in AG patients in comparison to CS what may have a potentially protective effect against anemia through an increased bioavailability of Fe. Additionally, GH may have a positive direct or indirect effect on erythropoiesis. Further studies on larger patient groups are necessary in order to clarify the exact role of hepcidin in the regulation of erythropoiesis in the excess of GH/IGF-1. | 2021 | Frontiers in endocrinology | No DOI | [
{
"LastName": "Krygier",
"FirstName": "Aleksandra",
"Affiliation": "Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland."
},
{
"LastName": "Szczepanek-Parulska",
"FirstName": "Ewelina",
"Affiliation": "Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland."
},
{
"LastName": "Cieślewicz",
"FirstName": "Maja",
"Affiliation": "Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland."
},
{
"LastName": "Wrotkowska",
"FirstName": "Elżbieta",
"Affiliation": "Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland."
},
{
"LastName": "Chanaj-Kaczmarek",
"FirstName": "Justyna",
"Affiliation": "Department of Pharmacognosy, Poznan University of Medical Sciences, Poznan, Poland."
},
{
"LastName": "Ruchała",
"FirstName": "Marek",
"Affiliation": "Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland."
}
] | No |
18244704 | Simultaneous homographic and comparametric alignment of multiple exposure-adjusted pictures of the same scene. | An approach is presented that can simultaneously align multiple exposure-adjusted pictures of the same scene both in their spatial coordinates as well as in their pixel values. The approach is featureless and produces an image mosaic at a common spatial and exposure reference and also addresses the misalignment problem common to methods that compose mosaics from only pair-wise registered image pairs. The objective function considered minimizes the sum of the collective variance over pixels of a global coordinate grid on which to create the final image. The models employed relate images spatially by homographic transformations and tonally by comparametric functions. The importance of performing joint spatial and tonal registration on exposure-adjusted images is emphasized by providing two examples in which spatial-only registration fails. A discussion describing the performance between pair-wise and simultaneous registration under both spatial-only and joint registration procedures is provided. | 2003 | IEEE transactions on image processing : a publication of the IEEE Signal Processing Society | No DOI | [
{
"LastName": "Candocia",
"FirstName": "Frank M",
"Affiliation": "Department of Electrical and Computer Engineering, Florida International University, Miami, FL 33174, USA. [email protected]"
}
] | No |
38407570 | A new case of sodium-dependent multivitamin transporter defect occurring as a life-threatening condition responsive to early vitamin supplementation and literature review. | Biallelic pathogenic variants in SLC5A6 resulting in sodium-dependent multivitamin transporter (SMVT) defect have recently been described as a vitamin-responsive inborn error of metabolism mimicking biotinidase deficiency. To our knowledge, only 16 patients have been reported so far with various clinical phenotypes such as neuropathy and other neurologic impairments, gastro-intestinal dysfunction and failure to thrive, osteopenia, immunodeficiency, metabolic acidosis, hypoglycemia, and recently severe cardiac symptoms. We describe a case report of a 5-month-old girl presenting two recurrent episodes of metabolic decompensation and massive cardiac failure in the course of an infectious disease. We compare clinical, biological, and genetic findings of this patient to previous literature collected from Pubmed database (keywords: Sodium-dependent multivitamin transporter (SMVT), SMVT defect/disorder/deficiency, SLC5A6 gene/mutation). We highlight the life-threatening presentation of this disease, the stagnation of psychomotor development, the severe and persistent hypogammaglobulinemia, and additionally, the successful clinical response on early vitamin supplementation (biotin 15 mg a day and pantothenic acid 100 mg a day). Metabolic assessment showed a persistent increase of urinary 3-hydroxyisovaleric acid (3-HIA) as previously reported in this disease in literature. SMVT deficiency is a vitamin-responsive inborn error of metabolism that can lead to a wide range of symptoms. Increased and isolated excretion of urinary 3-hydroxyisovaleric acid may suggest, in the absence of markedly reduced biotinidase activity, a SMVT deficiency. Prompt supplementation with high doses of biotin and pantothenic acid should be initiated while awaiting results of SLC5A6 sequencing as this condition may be life-threatening. | 2024 Feb | Molecular genetics & genomic medicine | No DOI | [
{
"LastName": "Van Vyve",
"FirstName": "F-X",
"Affiliation": "Pediatric Intensive Care Unit, Department of Pediatrics, Jolimont Hospital, La Louvière, Belgium."
},
{
"LastName": "Mercier",
"FirstName": "N",
"Affiliation": "Institut de Pathologie et de Génétique, Gosselies (Charleroi), Belgium."
},
{
"LastName": "Papadopoulos",
"FirstName": "J",
"Affiliation": "Pediatric Intensive Care Unit, Department of Pediatrics, Jolimont Hospital, La Louvière, Belgium."
},
{
"LastName": "Heijmans",
"FirstName": "C",
"Affiliation": "Institut de Pathologie et de Génétique, Gosselies (Charleroi), Belgium."
},
{
"LastName": "Dessy",
"FirstName": "H",
"Affiliation": "Pediatric Intensive Care Unit, Department of Pediatrics, Jolimont Hospital, La Louvière, Belgium."
},
{
"LastName": "Monestier",
"FirstName": "O",
"Affiliation": "Department of Molecular Biology, Institute of Pathology and Genetics, Charleroi, Belgium."
},
{
"LastName": "Dewulf",
"FirstName": "J P",
"Affiliation": "Biochemical Genetics and Newborn Screening Laboratory, Department of Clinical Chemistry, Cliniques Universitaires Saint-Luc, Brussels, Belgium."
},
{
"LastName": "Roland",
"FirstName": "D",
"Affiliation": "Department of Human Genetics, Center for Inherited Metabolic Disorders, Institute of Pathology and Genetics, Charleroi, Belgium."
}
] | No |
34079773 | Gold Standard Care of Chronic Scrotal Pain. | Chronic scrotal pain (CSP) can be a debilitating condition for patients and is often difficult to characterize. A review of literature was performed using Embase, Cochrane and Medline databases in the period 1.January 2010 to 1.January 2021. We found 132 articles, and the authors screened abstract and references. Thirty-seven articles are included after removing duplicates. This review presents a variety of medical and surgical treatment options for CSP such as spermatic cord blocks (36-80% success rate), microsurgical denervation of the spermatic cord (76-100% success rates), Botox (56% success rate), targeted ilioinguinal and iliohypogastric peripheral nerve stimulation, and radical orchiectomy (55-75% success rate). An overview of various treatment options, both non-surgical and surgical are provided, with the aim of establishing what may be the best treatment option for CSP. | 2021 | Research and reports in urology | No DOI | [
{
"LastName": "Malaguti",
"FirstName": "Stefan Artell",
"Affiliation": "Department of Urology, Odense University Hospital, Odense, Denmark."
},
{
"LastName": "Lund",
"FirstName": "Lars",
"Affiliation": "Department of Urology, Odense University Hospital, Odense, Denmark."
}
] | No |
38855078 | Work-related musculoskeletal disorders and risk factors among weavers: A cross-sectional study. | Work-related musculoskeletal disorders (WRMSDs) are a major health issue for low-income countries because of their high prevalence among workers and on account of the scarcity of ergonomic preventative measures in the workplace. To determine the prevalence of WRMSDs among weavers, assess their consequences, and analyse the associated occupational risk factors. A cross-sectional survey was carried out among 257 handloom weavers using the Nordic questionnaireand the working conditions were assessed through a descriptive analysis using the key indicator method. The WRMSDs annual prevalence was 85% in all parts of the body, 71% for the low back region, 41% for the shoulders, and 37% for the knees. One quarter of the weavers indicated having stopped work for 1-30 days because of their low back pain (LBP). The prevalence of WRMSDs was associated with the number of hours worked per day, the years of experience, and age. Long working hours, load carrying (> 20 kg - 25 kg), awkward postures, repetitive limb movements, and unfavourable environmental conditions were identified as occupational risk factors. Work-related musculoskeletal disorders are common among weavers and LBP is the most frequently cited disorder and the primary reason for work interruptions and a decrease of activities. The prevalence of WRMSDs is associated with professional and personal factors. Actions based on ergonomic rules are necessary to prevent WRMSDs. Our study highlights the issue of WRMSDs and the need for prevention in the informal sector, which constitutes the major part of economic activity in low-income countries. | 2023 | The South African journal of physiotherapy | No DOI | [
{
"LastName": "Kaboré",
"FirstName": "Pegdwendé A",
"Affiliation": "Laboratory of Physiology and Biomechanics of Locomotion-Institute of Neuroscience, Faculty of Movement and Rehabilitation Sciences, Catholic University of Louvain, Louvain-la-Neuve, Belgium."
},
{
"LastName": "Schepens",
"FirstName": "Bénédicte",
"Affiliation": "Laboratory of Physiology and Biomechanics of Locomotion-Institute of Neuroscience, Faculty of Movement and Rehabilitation Sciences, Catholic University of Louvain, Louvain-la-Neuve, Belgium."
}
] | No |
33133695 | Impact of Application of Multifunction Electrode (MFE) Pads on Cardiopulmonary Resuscitation Quality. | Early defibrillation and high-quality chest compressions are crucial in treatment of sudden cardiac arrest (SCA) subjects. The aim of this study was to assess an impact of defibrillation methods on cardiopulmonary resuscitation (CPR) quality. A randomized simulation cross-study was designed, in which 100 two-person paramedical teams participated. Two 10-minute scenarios of SCA in the mechanism of ventricular fibrillation were analysed. In the first one, teams had at their disposal defibrillator with hard paddles (group C), whereas in the second one, adhesive electrodes were used (group MFE). The CPR quality was evaluated on the basis of the chest compression parameters (rate, depth, recoil, compression fraction (CCF), and no-flow time), airways patency achievement, and successful emergency drug administration. Substituting standard hard paddles with adhesive electrodes led to an increase in CCF (77% vs 73%; p < 0.05), higher rate of complete chest recoil, and a decrease in no-flow time (6.0 ± 1.1 vs. 7.3 ± 1.1; p < 0.001). The airway patency was ensured sooner in group MFE (271 ± 118 s vs. 322 ± 106 s in group C; p < 0.001). All teams in scenario with adhesive electrodes were able to administer two doses of adrenaline, meanwhile only 74% of them in group C (p < 0.001). Moreover, in 8% of group C scenarios, paramedics did not have enough time to administer amiodarone. Our simulation-based analysis revealed that use of adhesive electrodes during defibrillation instead of standard hard paddles may improve the quality of CPR performed by two-person emergency team. | 2020 | Emergency medicine international | No DOI | [
{
"LastName": "Zalewski",
"FirstName": "Radosław",
"Affiliation": "Department of Medical Rescue, Chair of Emergency Medicine, Poznan University of Medical Sciences, Collegium Adama Wrzoska Rokietnicka Street 7, Poznan 60-806, Poland."
},
{
"LastName": "Puślecki",
"FirstName": "Mateusz",
"Affiliation": "Department of Medical Rescue, Chair of Emergency Medicine, Poznan University of Medical Sciences, Collegium Adama Wrzoska Rokietnicka Street 7, Poznan 60-806, Poland."
},
{
"LastName": "Szarpak",
"FirstName": "Łukasz",
"Affiliation": "Maria Sklodowska-Curie Medical Academy in Warsaw, 12 Solidarnosci Av., 03-411 Warsaw, Poland."
},
{
"LastName": "Kłosiewicz",
"FirstName": "Tomasz",
"Affiliation": "Department of Medical Rescue, Chair of Emergency Medicine, Poznan University of Medical Sciences, Collegium Adama Wrzoska Rokietnicka Street 7, Poznan 60-806, Poland."
},
{
"LastName": "Dąbrowski",
"FirstName": "Marek",
"Affiliation": "Chair and Department of Medical Education, Poznan University of Medical Sciences, Collegium Adama Wrzoska Rokietnicka Street 7, Poznan 60-806, Poland."
},
{
"LastName": "Perek",
"FirstName": "Bartłomiej",
"Affiliation": "Department of Cardiac Surgery and Transplantology, Chair of Cardiac and Thoracic Surgery, Poznan University of Medical Sciences, Dluga Street 1/2, Poznan 61-848, Poland."
}
] | No |
17281740 | Ultrasound speckle suppression and edge enhancement using multiscale nonlinear wavelet diffusion. | This paper introduces a novel multiscale nonlinear wavelet diffusion (MNWD) method for ultrasound speckle suppression and edge enhancement. It considers wavelet diffusion as an approximation to nonlinear diffusion within the framework of the dyadic wavelet transform. Consequently, this knowledge is exploited in the design of a speckle suppression filter with an edge enhancement feature. MNWD takes advantage of the sparsity and multiresolution properties of wavelet, and the iterative edge enhancement feature of nonlinear diffusion. In our algorithm, speckle is suppressed by employing the iterative multiscale diffusion on the wavelet coefficients, while the edges of the image are enhanced by using an iterative signal compensation process. We validate the proposed method using synthetic and real echocardiographic images. Performance improvement over other traditional denoising filters is quantified in terms of noise suppression and structural preservation indices. The application of the proposed method is demonstrated by the segmentation of the echocardiographic image using the active contour. | 2005 | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference | No DOI | [
{
"LastName": "Yue",
"FirstName": "Yong",
"Affiliation": "Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005 USA. [email protected]"
},
{
"LastName": "Croitoru",
"FirstName": "Mihai M",
"Affiliation": ""
},
{
"LastName": "Bidani",
"FirstName": "Akhil",
"Affiliation": ""
},
{
"LastName": "Zwischenberger",
"FirstName": "Joseph B",
"Affiliation": ""
},
{
"LastName": "Clark",
"FirstName": "John W",
"Affiliation": ""
}
] | No |
28835671 | A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats. | Muscle atrophy is one of the serious complications of chronic kidney disease (CKD). Dysregulation of mitochondrial quality control (MQC) process, including decrease mitochondrial biogenesis, impair mitochondrial dynamics and induce activation of mitophagy, play an important role in mediating muscle wasting. This study aimed to observe effects of Jian-Pi-Yi-Shen (JPYS) decoction on muscle atrophy in CKD rats and explore its possible mechanism on regulation of MQC processes. The 5/6 nephrectomised rats were randomly allocated into 2 groups: CKD group and JPYS group. Besides, a sham-operated rats as sham group. All rats were treated for 6 weeks. Results showed that administration of JPYS decoction prevented body weight loss, muscle loss, muscle fiber size decrease, muscle protein degradation, and increased muscle protein systhesis. In addition, JPYS decoction increased the mitochondrial content and biogenesis proteins, and down-regulated the autophagy and mitophagy proteins. Furthermore, JPYS decoction increased mitochondrial fusion proteins, while decreased mitochondrial fission proteins. In conclusion, JPYS decoction increased mitochondrial content and biogenesis, restore the balance between fission and fusion, and inhibited autophagy-lysosome pathway (mitophagy). Collectively, our data showed that JPYS decoction to be beneficial to muscle atrophy in CKD, which might be associated with the modulation of MQC process. | 2017 Aug 23 | Scientific reports | No DOI | [
{
"LastName": "Wang",
"FirstName": "Dongtao",
"Affiliation": "Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, 518033, China. [email protected]."
},
{
"LastName": "Chen",
"FirstName": "Jianping",
"Affiliation": "Shenzhen Key Laboratory of Hospital Chinese Medicine Preparation, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, 518033, China."
},
{
"LastName": "Liu",
"FirstName": "Xinhui",
"Affiliation": "Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, 518033, China."
},
{
"LastName": "Zheng",
"FirstName": "Ping",
"Affiliation": "Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, 518033, China."
},
{
"LastName": "Song",
"FirstName": "Gaofeng",
"Affiliation": "Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, 518033, China."
},
{
"LastName": "Yi",
"FirstName": "Tiegang",
"Affiliation": "Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, 518033, China. [email protected]."
},
{
"LastName": "Li",
"FirstName": "Shunmin",
"Affiliation": "Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, 518033, China. [email protected]."
}
] | Yes |
39012868 | Correlates of susceptibility to waterpipe tobacco smoking in young adults. | Many US young adults are susceptible to waterpipe (i.e., hookah) tobacco smoking (WTS) initiation, but research on factors associated with WTS susceptibility is limited. We examined sociodemographic, other tobacco and substance use, and attitudes and perceptions correlates of WTS susceptibility among young adults. Baseline data from a randomized trial testing WTS risk messages was collected in US young adults aged 18 to 30 years who never used waterpipe tobacco but were susceptible to WTS (n = 294). Extent of susceptibility to WTS was defined using the average score of a valid scale with higher scores indicating higher susceptibility. Correlates were sociodemographics, other tobacco and substance use, and attitudes and perceptions. Multiple linear regression models identified correlates of greater WTS susceptibility. Participants averaged 25 (SD 3.2) years of age, 60% were male, 22% were Black non-Hispanic, 47% completed some college education, and 66% were employed. Our models consistently showed that more positive attitudes toward WTS (β = -0.08, p<0.01), lower perceived addictiveness relative to cigarettes (β = -0.09, p = 0.04), and greater perceived social acceptability of WTS (β = 0.05, p<0.01) were positively correlated with WTS susceptibility. Additionally, young adults who smoked cigarillos (β = 0.53, p<0.01), used cannabis (β = 0.14, p = 0.02), and Black non-Hispanic versus White non-Hispanic young adults (β = 0.18, p = 0.03) also had higher WTS susceptibility. Findings suggest that WTS prevention efforts require multicomponent interventions including targeting subpopulations at greater risk based on race/ethnicity and other tobacco and substance use. These interventions should consider attitudes and social acceptability of WTS as modifiable targets to maximize public health benefits. | 2024 | PloS one | No DOI | [
{
"LastName": "Alalwan",
"FirstName": "Mahmood A",
"Affiliation": "Department of Internal Medicine, The Ohio State University College of Medicine, Center for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America."
},
{
"LastName": "Long",
"FirstName": "Lauren",
"Affiliation": "Department of Internal Medicine, The Ohio State University College of Medicine, Center for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America."
},
{
"LastName": "Stevens",
"FirstName": "Elise M",
"Affiliation": "Division of Preventive and Behavioral Medicine, Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America."
},
{
"LastName": "Keller-Hamilton",
"FirstName": "Brittney",
"Affiliation": "Department of Internal Medicine, The Ohio State University College of Medicine, Center for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America."
},
{
"LastName": "Villanti",
"FirstName": "Andrea C",
"Affiliation": "Department of Health, Behavior, Society, and Policy, Rutgers School of Public Health, Rutgers Institute for Nicotine & Tobacco Studies, New Brunswick, New Jersey, United States of America."
},
{
"LastName": "Leshner",
"FirstName": "Glenn",
"Affiliation": "Gaylord College of Journalism and Mass Communication, University of Oklahoma, Norman, Oklahoma, United States of America."
},
{
"LastName": "Wagener",
"FirstName": "Theodore L",
"Affiliation": "Department of Internal Medicine, The Ohio State University College of Medicine, Center for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America."
},
{
"LastName": "Mays",
"FirstName": "Darren",
"Affiliation": "Department of Internal Medicine, The Ohio State University College of Medicine, Center for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America."
}
] | No |
18409286 | [Smoking influence on the level of homocysteine and 5-methyltetrahydrofolic acid in active and non smokers]. | Cigarette smoking is associated with oxidative stress and increased risk of many chronic diseased. Smoking inducts depletion of cellular antioxidant and is also known to be associated with an increased homocysteine level. Exposure to tobacco smoke has negative impact on the folic acid level. Folic acid is cofactor by demethyla-tion of homocysteine to non toxic methionine. The aim of this study was to determine the concentration of total plasma homocysteine and 5-methyltetrahydrofolic acid in active and non smokers and to evaluate the influence of the tobacco smoke exposure on urinary cotinine levels. The results indicated significant increase of total plasma homocysteine in smokers, than non smokers. We also investigated the negative influence of tobacco smoke on the level of folic acid in plasma and it suggests, that additional supplementation of folic acid in smokers is necessary. | 2007 | Przeglad lekarski | No DOI | [
{
"LastName": "Marszałł",
"FirstName": "Marcin",
"Affiliation": "Katedra i Zakład Toksykologii, Akademia Medyczna w Gdańsku. [email protected]"
},
{
"LastName": "Czarnowski",
"FirstName": "Wojciech",
"Affiliation": ""
}
] | No |
31908490 | Upregulated miR-27a-3p Indicates a Poor Prognosis in Pancreatic Carcinoma Patients and Promotes the Angiogenesis and Migration by Epigenetic Silencing of GATA6 and Activating VEGFA/VEGFR2 Signaling Pathway. | Abnormal miR-27a-3p expression has been frequently reported in several types of human cancer and contributes to tumor progression. However, the role and potential molecular mechanism of miR-27a-3p in the progression of pancreatic carcinoma have not been clarified. The expression of miR-27a-3p and GATA binding protein 6 (GATA6) in pancreatic carcinoma tissues and cell lines was evaluated by quantitative real-time PCR and Western blotting analysis. The relationship between clinical pathologic features and miR-27a-3p expression was analyzed with Chi-square test. The regulatory mechanism of miR-27a-3p on GATA6 was confirmed by luciferase reporter assay and bioinformatics analysis. The effects of miR-27a-3p by targeting GATA6 on cell angiogenesis and migration were assessed by capillary tube formation and wound healing assays. MiR-27a-3p expression was significantly upregulated in pancreatic carcinoma tissues and cell lines. Highly expressed miR-27a-3p was closely related to more lymph node metastasis, present peritoneal metastasis, and poor prognosis in patients with pancreatic carcinoma. MiR-27a-3p promoted migration and angiogenesis of pancreatic carcinoma cells by activating vascular endothelial growth factor A (VEGFA) and vascular endothelial growth factor receptor 2 (VEGFR2) expression. A significantly negative correlation between GATA6 mRNA and miR-27a-3 expression was found in pancreatic carcinoma samples. Modulation of miR-27a-3p could alter GATA6 expression in pancreatic carcinoma cells. GATA6 was identified as a functional target gene of miR-27a-3p, and GATA6 knockdown partially reversed the effects of miR-27a-3p siliencing on the migration and angiogenesis of pancreatic carcinoma cells by regulation of VEGFA/VEGFR2 pathway. Upregulated miR-27a-3p indicates a poor prognosis in pancreatic carcinoma patients and promotes the angiogenesis and migration by epigenetic silencing of GATA6 and activating VEGFA/VEGFR2 signaling pathway, and indicating miR-27a-3p may be a promising therapeutic target for pancreatic carcinoma treatment. | 2019 | OncoTargets and therapy | No DOI | [
{
"LastName": "Rao",
"FirstName": "Xuefeng",
"Affiliation": "Department of General Surgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang 330006, People's Republic of China."
},
{
"LastName": "Wan",
"FirstName": "Lihui",
"Affiliation": "Department of Gastroenterology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang 330006, People's Republic of China."
},
{
"LastName": "Jie",
"FirstName": "Zhigang",
"Affiliation": "Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, People's Republic of China."
},
{
"LastName": "Zhu",
"FirstName": "Xiaoliang",
"Affiliation": "Department of General Surgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang 330006, People's Republic of China."
},
{
"LastName": "Yin",
"FirstName": "Junxiang",
"Affiliation": "Department of General Surgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang 330006, People's Republic of China."
},
{
"LastName": "Cao",
"FirstName": "Hong",
"Affiliation": "Department of General Surgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang 330006, People's Republic of China."
}
] | Yes |
25436421 | MicroRNA-520g induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7. | Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Aberrant expression of miRNAs contributes to HCC development. Here, we observed elevated miR-520g expression in tumor samples from HCC patients with relapse and metastasis, and this high miR-520g expression was correlated with poor survival. Through gain- and loss-of-function studies, miR-520g was demonstrated to facilitate HCC cell migration, invasion and epithelial-mesenchymal transition (EMT). SMAD7 was identified as a direct target of miR-520g. Accordingly, we conclude that high miR-520g expression promotes HCC cell mobility and EMT by targeting SMAD7, and this is correlated with reduced survival in HCC patients. | 2015 Jan 2 | FEBS letters | No DOI | [
{
"LastName": "Kan",
"FirstName": "Heping",
"Affiliation": "Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road North, Guangzhou 510515, China. Electronic address: [email protected]."
},
{
"LastName": "Guo",
"FirstName": "Wenbin",
"Affiliation": "Department of Urology, The Third Affiliated Hospital, Southern Medical University, No. 183 Zhongshan Road West, Guangzhou 510000, China. Electronic address: [email protected]."
},
{
"LastName": "Huang",
"FirstName": "Yuqi",
"Affiliation": "Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road North, Guangzhou 510515, China. Electronic address: [email protected]."
},
{
"LastName": "Liu",
"FirstName": "Dingli",
"Affiliation": "Department of Infectious Disease, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road North, Guangzhou 510515, China. Electronic address: [email protected]."
}
] | Yes |
19152690 | Facts, values, and attention-deficit hyperactivity disorder (ADHD): an update on the controversies. | The Hastings Center, a bioethics research institute, is holding a series of 5 workshops to examine the controversies surrounding the use of medication to treat emotional and behavioral disturbances in children. These workshops bring together clinicians, researchers, scholars, and advocates with diverse perspectives and from diverse fields. Our first commentary in CAPMH, which grew out of our first workshop, explained our method and explored the controversies in general. This commentary, which grows out of our second workshop, explains why informed people can disagree about ADHD diagnosis and treatment. Based on what workshop participants said and our understanding of the literature, we make 8 points. (1) The ADHD label is based on the interpretation of a heterogeneous set of symptoms that cause impairment. (2) Because symptoms and impairments are dimensional, there is an inevitable "zone of ambiguity," which reasonable people will interpret differently. (3) Many other variables, from different systems and tools of diagnosis to different parenting styles and expectations, also help explain why behaviors associated with ADHD can be interpreted differently. (4) Because people hold competing views about the proper goals of psychiatry and parenting, some people will be more, and others less, concerned about treating children in the zone of ambiguity. (5) To recognize that nature has written no bright line between impaired and unimpaired children, and that it is the responsibility of humans to choose who should receive a diagnosis, does not diminish the significance of ADHD. (6) Once ADHD is diagnosed, the facts surrounding the most effective treatment are complicated and incomplete; contrary to some popular wisdom, behavioral treatments, alone or in combination with low doses of medication, can be effective in the long-term reduction of core ADHD symptoms and at improving many aspects of overall functioning. (7) Especially when a child occupies the zone of ambiguity, different people will emphasize different values embedded in the pharmacological and behavioral approaches. (8) Truly informed decision-making requires that parents (and to the extent they are able, children) have some sense of the complicated and incomplete facts regarding the diagnosis and treatment of ADHD. | 2009 Jan 19 | Child and adolescent psychiatry and mental health | No DOI | [
{
"LastName": "Parens",
"FirstName": "Erik",
"Affiliation": "The Hastings Center, Garrison, New York 10524, USA. [email protected]"
},
{
"LastName": "Johnston",
"FirstName": "Josephine",
"Affiliation": ""
}
] | No |
38733690 | Effects of Apatinib combined with Temozolomide on levels of sPD-1 and sPD-L1 in patients with drug-resistant recurrent glioblastoma. | This study aimed to explore the effects of Apatinib combined with Temozolomide (TMZ) on the levels of Soluble PD-1 (sPD-1) and Soluble Programmed Death-1 Ligand (sPD-L1) in patients with drug-resistant recurrent Glioblastoma (GB). A total of 69 patients with recurrent GB from September 2020 to March 2022 were recruited and assigned to the control group (n = 34) and observation group (n = 35) according to different treatment options after tumor recurrence. The control group was treated with TMZ, and the observation group was treated with Apatinib combined with TMZ. Levels of sPD-1 and spd-l1, clinical efficacy, survival time and adverse reactions were observed and compared between the two groups. General data including gender, age, body mass index, and combined diseases indicated no statistical significance between groups (p > 0.05). Before the intervention, sPD-1 and sPD-L1 levels were not significantly different in the two groups (p > 0.05). After interventions, levels of PD-1 and sPD-L1 levels decreased significantly (p < 0.05). The objective remission rate and clinical benefit rate of the observation group were higher and overall survival and progression-free survival were longer than those of the control group (p < 0.05). No significant difference was observed in major adverse reactions among patients (p > 0.05). Apatinib combined with TMZ is safe and effective in the treatment of recurrent GB. The combined application of the two can reduce the levels of sPD-1 and sPD-L1, which has important clinical application value. | 2024 | Clinics (Sao Paulo, Brazil) | No DOI | [
{
"LastName": "Kuang",
"FirstName": "Ren Zhao",
"Affiliation": "Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, China."
},
{
"LastName": "Wang",
"FirstName": "Jun",
"Affiliation": "Department of Orthopedics and Cosmetology, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, China."
},
{
"LastName": "Wang",
"FirstName": "Yuan Chuan",
"Affiliation": "Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, China."
},
{
"LastName": "Tang",
"FirstName": "Xiao Ping",
"Affiliation": "Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, China. Electronic address: [email protected]."
}
] | No |
38828096 | Super resolution deep learning reconstruction for coronary CT angiography: A structured phantom study. | Super-resolution deep-learning-based reconstruction: SR-DLR is a newly developed and clinically available deep-learning-based image reconstruction method that can improve the spatial resolution of CT images. The image quality of the output from non-linear image reconstructions, such as DLR, is known to vary depending on the structure of the object being scanned, and a simple phantom cannot explicitly evaluate the clinical performance of SR-DLR. This study aims to accurately investigate the quality of the images reconstructed by SR-DLR by utilizing a structured phantom that simulates the human anatomy in coronary CT angiography. The structural phantom had ribs and vertebrae made of plaster, a left ventricle filled with dilute contrast medium, a coronary artery with simulated stenosis, and an implanted stent graft. By scanning the structured phantom, we evaluated noise and spatial resolution on the images reconstructed with SR-DLR and conventional reconstructions. The spatial resolution of SR-DLR was higher than conventional reconstructions; the 10 % modulation transfer function of hybrid IR (HIR), DLR, and SR-DLR were 0.792-, 0.976-, and 1.379 cycle/mm, respectively. At the same time, image noise was lowest (HIR: 21.1-, DLR: 19.0-, and SR-DLR: 13.1 HU). SR-DLR could accurately assess coronary artery stenosis and the lumen of the implanted stent graft. SR-DLR can obtain CT images with high spatial resolution and lower noise without special CT equipments, and will help diagnose coronary artery disease in CCTA and other CT examinations that require high spatial resolution. | 2024 Jun | European journal of radiology open | No DOI | [
{
"LastName": "Higaki",
"FirstName": "Toru",
"Affiliation": "Graduate School of Advanced Science and Engineering, Hiroshima University, Japan."
},
{
"LastName": "Tatsugami",
"FirstName": "Fuminari",
"Affiliation": "Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan."
},
{
"LastName": "Ohana",
"FirstName": "Mickaël",
"Affiliation": "Dept. Radiology, University of Strasbourg, France."
},
{
"LastName": "Nakamura",
"FirstName": "Yuko",
"Affiliation": "Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan."
},
{
"LastName": "Kawashita",
"FirstName": "Ikuo",
"Affiliation": "Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan."
},
{
"LastName": "Awai",
"FirstName": "Kazuo",
"Affiliation": "Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan."
}
] | No |
6416748 | Radionuclide analysis of sequential changes in central circulatory volumes: inspiration, expiration, and the Valsalva maneuver. | We evaluated the effects of deep inspiration, expiration, and the Valsalva maneuver on composite cardiac (left and right ventricular) and pulmonary volumes using equilibrium radionuclide angiography in 15 adult males without left or right ventricular dysfunction. The additional effects of nitroglycerin during these maneuvers were also examined. Midexpiration was used as the control point and data analyzed as a ratio (e.g., inspiration counts divided by midexpiration counts). Left ventricular volume (LVV) declined with inspiration (0.90 +/- 0.08 inspiratory/midexpiration) and with the Valsalva maneuver (0.89 +/- 0.08 Valsalva/midexpiration). Similar changes occurred after nitroglycerin, although the effects of the Valsalva maneuver on LVV were exaggerated when compared to the initial control intervention (0.79 +/- 0.09, vs 0.88 +/- 0.07, p less than .05). Right ventricular volume (RVV) increased with inspiration and decreased with the Valsalva maneuver; these changes were similar after nitroglycerin. Pulmonary blood volume (PBV) was greater with inspiration than expiration (1.02 +/- 0.10 vs 0.95 +/- 0.05, p less than .05), and was reduced with the Valsalva maneuver. Nitroglycerin reduced significantly all volumes and the reduction was similar for each compartment when respiratory interventions were compared. We conclude that blood pool imaging can be used to characterize abrupt fluxes in central circulatory volumes. Blood pool imaging of the heart and lungs should be considered a technique for monitoring the distribution of blood volume during acute pharmacologic and physiologic alterations. | 1983 Dec | Critical care medicine | No DOI | [
{
"LastName": "Slutsky",
"FirstName": "R A",
"Affiliation": ""
},
{
"LastName": "Dittrich",
"FirstName": "H",
"Affiliation": ""
},
{
"LastName": "Peck",
"FirstName": "W W",
"Affiliation": ""
}
] | Yes |
25664124 | Genetic variants of STAT4 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population. | Genetic factors play an important role in ankylosing spondylitis (AS) etiology and signal transducer and activator of transcription 4 (STAT4) gene polymorphisms may be involved. The aim of this study was to test whether STAT4 variants were associated with susceptibility to AS in a Chinese population. A total of 175 subjects who were diagnosed as AS and 249 healthy age-matched controls were enrolled in the present study. The rs7574865 G/T SNP in STAT4 gene was genotyped in all the subjects. The SPSS software was used to investigate the association between the rs7574865 genotypes and AS susceptibility or severity. Rs7574865 G/T was found to be significantly associated with increased risk and severity of AS. Our data demonstrated the STAT4 rs7574865 G/T SNP was significantly associated with increased AS susceptibility and severity in Chinese Han Population. | 2014 | International journal of clinical and experimental medicine | No DOI | [
{
"LastName": "Liu",
"FirstName": "Zhixiang",
"Affiliation": "Department of Nuclear Medicine, The Hospital Affiliated of Weifang Medical University Kuiwen Region 261031, Weifang City, Shandong Province, China."
},
{
"LastName": "Zhang",
"FirstName": "Peisen",
"Affiliation": "Department of Nuclear Medicine, The Hospital Affiliated of Weifang Medical University Kuiwen Region 261031, Weifang City, Shandong Province, China."
},
{
"LastName": "Dong",
"FirstName": "Jie",
"Affiliation": "Department of Nuclear Medicine, The Hospital Affiliated of Weifang Medical University Kuiwen Region 261031, Weifang City, Shandong Province, China."
}
] | No |
24626971 | Long latency auditory evoked potentials in children with cochlear implants: systematic review. | The aim of this study was to analyze the findings on Cortical Auditory Evoked Potentials in children with cochlear implant through a systematic literature review. After formulation of research question and search of studies in four data bases with the following descriptors: electrophysiology (eletrofisiologia), cochlear implantation (implante coclear), child (criança), neuronal plasticity (plasticidade neuronal) and audiology (audiologia), were selected articles (original and complete) published between 2002 and 2013 in Brazilian Portuguese or English. A total of 208 studies were found; however, only 13 contemplated the established criteria and were further analyzed; was made data extraction for analysis of methodology and content of the studies. The results described suggest rapid changes in P1 component of Cortical Auditory Evoked Potentials in children with cochlear implants. Although there are few studies on the theme, cochlear implant has been shown to produce effective changes in central auditory path ways especially in children implanted before 3 years and 6 months of age. | 2013 | CoDAS | No DOI | [
{
"LastName": "Silva",
"FirstName": "Liliane Aparecida Fagundes",
"Affiliation": "Universidade de São Paulo, School of Medicine, São PauloSP, Brazil, School of Medicine, Universidade de São Paulo - USP - São Paulo (SP), Brazil."
},
{
"LastName": "Couto",
"FirstName": "Maria Inês Vieira",
"Affiliation": "Universidade de São Paulo, School of Medicine, São PauloSP, Brazil, School of Medicine, Universidade de São Paulo - USP - São Paulo (SP), Brazil."
},
{
"LastName": "Matas",
"FirstName": "Carla Gentile",
"Affiliation": "Universidade de São Paulo, School of Medicine, São PauloSP, Brazil, School of Medicine, Universidade de São Paulo - USP - São Paulo (SP), Brazil."
},
{
"LastName": "Carvalho",
"FirstName": "Ana Claudia Martinho de",
"Affiliation": "Universidade de São Paulo, School of Medicine, São PauloSP, Brazil, School of Medicine, Universidade de São Paulo - USP - São Paulo (SP), Brazil."
}
] | No |
38814870 | Solar-enhanced lithium extraction with self-sustaining water recycling from salt-lake brines. | Lithium is an emerging strategic resource for modern energy transformation toward electrification and decarbonization. However, current mainstream direct lithium extraction technology via adsorption suffers from sluggish kinetics and intensive water usage, especially in arid/semiarid and cold salt-lake regions (natural land brines). Herein, an efficient proof-of-concept integrated solar microevaporator system is developed to realize synergetic solar-enhanced lithium recovery and water footprint management from hypersaline salt-lake brines. The 98% solar energy harvesting efficiency of the solar microevaporator system, elevating its local temperature, greatly promotes the endothermic Li[+] extraction process and solar steam generation. Benefiting from the photothermal effect, enhanced water flux, and enriched local Li[+] supply in nanoconfined space, a double-enhanced Li[+] recovery capacity was delivered (increase from 12.4 to 28.7 mg g[-1]) under one sun, and adsorption kinetics rate (saturated within 6 h) also reached twice of that at 280 K (salt-lake temperature). Additionally, the self-assembly rotation feature endows the microevaporator system with distinct self-cleaning desalination ability, achieving near 100% water recovery from hypersaline brines for further self-sufficient Li[+] elution. Outdoor comprehensive solar-powered experiment verified the feasibility of basically stable lithium recovery ability (>8 mg g[-1]) directly from natural hypersaline salt-lake brines with self-sustaining water recycling for Li[+] elution (440 m[3] water recovery per ton Li2CO3). This work offers an integrated solution for sustainable lithium recovery with near zero water/carbon consumption toward carbon neutrality. | 2024 Jun 4 | Proceedings of the National Academy of Sciences of the United States of America | No DOI | [
{
"LastName": "Xia",
"FirstName": "Qiancheng",
"Affiliation": "State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China."
},
{
"LastName": "Deng",
"FirstName": "Zehui",
"Affiliation": "State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China."
},
{
"LastName": "Sun",
"FirstName": "Siwei",
"Affiliation": "School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China."
},
{
"LastName": "Zhao",
"FirstName": "Wei",
"Affiliation": "State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China."
},
{
"LastName": "Ding",
"FirstName": "Jie",
"Affiliation": "State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China."
},
{
"LastName": "Xi",
"FirstName": "Beidou",
"Affiliation": "State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China."
},
{
"LastName": "Gao",
"FirstName": "Guandao",
"Affiliation": "State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China."
},
{
"LastName": "Wang",
"FirstName": "Chao",
"Affiliation": "School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China."
}
] | No |
37782174 | Systemic inflammation response index is associated MACE in patients with NSTEMI. | Non-ST segment elevation myocardial infarction (NSTEMI) poses a significant health concern. The systemic inflammation response index (SIRI), an emerging inflammatory marker linked to conditions like stroke and cancer, has shown potential relevance. Inflammation's pivotal role in acute coronary syndromes is well-established, yet its specific association with NSTEMI and SIRI remains unexplored. This study aims to elucidate the correlation between SIRI and major adverse cardiovascular events (MACE) in patients with NSTEMI. A cohort of 935 consecutive NSTEMI patients who underwent percutaneous intervention was recruited. MACE was defined to encompass all-cause death, malignant arrhythmia, and unplanned percutaneous coronary intervention. The systemic inflammation response index, a composite metric involving three distinct inflammatory cell counts, was computed as the product of neutrophil count and monocyte count divided by lymphocyte count. A receiver operator characteristic (ROC) curve analysis was used to define a cut-off level of SIRI to predict MACE. Then, the study population was divided into two groups according to the cut-off SIRI level in ROC curve analysis. The 12-month follow-up results of the patients were recorded retrospectively. The participants exhibited a mean age of 64.12. Notably, the mean SIRI level registered at 1.98 among patients experiencing MACE and 4.97 among others. Through rigorous multivariate logistic regression analysis, SIRI emerged as an independent predictor of MACE. Further analysis via ROC curve yielded a sensitivity of 68% and specificity of 76% for MACE detection, with a SIRI cut-off of 2.3. In the context of NSTEMI, SIRI emerges as a robust independent predictor of MACE. These findings underscore the potential utility of SIRI as a prognostic indicator for adverse cardiovascular events, enhancing our understanding of the disease's pathophysiological mechanisms and potential avenues for improved clinical management. | 2023 Sep | European review for medical and pharmacological sciences | No DOI | [
{
"LastName": "Ozilhan",
"FirstName": "M O",
"Affiliation": "Department of Cardiology, Ankara City Hospital, Ankara, Turkey. [email protected]."
},
{
"LastName": "Çakmak Karaaslan",
"FirstName": "O",
"Affiliation": ""
},
{
"LastName": "Acikgoz",
"FirstName": "S K",
"Affiliation": ""
},
{
"LastName": "Selcuk",
"FirstName": "H",
"Affiliation": ""
},
{
"LastName": "Selcuk",
"FirstName": "M T",
"Affiliation": ""
},
{
"LastName": "Maden",
"FirstName": "O",
"Affiliation": ""
}
] | No |
38959255 | Molecular epidemiology of enteroviruses from Guatemalan wastewater isolated from human lung fibroblasts. | The Global Specialized Polio Laboratory at CDC supports the Global Poliovirus Laboratory Network with environmental surveillance (ES) to detect the presence of vaccine strain polioviruses, vaccine-derived polioviruses, and wild polioviruses in high-risk countries. Environmental sampling provides valuable supplementary information, particularly in areas with gaps in surveillance of acute flaccid paralysis (AFP) mainly in children less than 15 years. In collaboration with Guatemala's National Health Laboratory (Laboratorio Nacional de Salud Guatemala), monthly sewage collections allowed screening enterovirus (EV) presence without incurring additional costs for sample collection, transport, or concentration. Murine recombinant fibroblast L-cells (L20B) and human rhabdomyosarcoma (RD) cells are used for the isolation of polioviruses following a standard detection algorithm. Though non-polio-Enteroviruses (NPEV) can be isolated, the algorithm is optimized for the detection of polioviruses. To explore if other EV's are present in sewage not found through standard methods, five additional cell lines were piloted in a small-scale experiment, and next-generation sequencing (NGS) was used for the identification of any EV types. Human lung fibroblast cells (HLF) were selected based on their ability to isolate EV-A genus. Sewage concentrates collected between 2020-2021 were isolated in HLF cells and any cytopathic effect positive isolates used for NGS. A large variety of EVs, including echoviruses 1, 3, 6, 7, 11, 13, 18, 19, 25, 29; coxsackievirus A13, B2, and B5, EV-C99, EVB, and polioviruses (Sabin 1 and 3) were identified through genomic typing in NGS. When the EV genotypes were compared by phylogenetic analysis, it showed many EV's were genomically like viruses previously isolated from ES collected in Haiti. Enterovirus occurrence did not follow a seasonality, but more diverse EV types were found in ES collection sites with lower populations. Using the additional cell line in the existing poliovirus ES algorithm may add value by providing data about EV circulation, without additional sample collection or processing. Next-generation sequencing closed gaps in knowledge providing molecular epidemiological information on multiple EV types and full genome sequences of EVs present in wastewater in Guatemala. | 2024 | PloS one | No DOI | [
{
"LastName": "Sayyad",
"FirstName": "Leanna",
"Affiliation": "Contracting Agency to the Division of Viral Diseases, Cherokee Nation Assurance, Tulsa, Oklahoma, United States of America."
},
{
"LastName": "Harrington",
"FirstName": "Chelsea",
"Affiliation": "Division of Viral Diseases, Polio and Picornavirus Branch, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America."
},
{
"LastName": "Castro",
"FirstName": "Christina J",
"Affiliation": "Contracting Agency to the Division of Viral Diseases, Cherokee Nation Assurance, Tulsa, Oklahoma, United States of America."
},
{
"LastName": "Belgasmi-Allen",
"FirstName": "Hanen",
"Affiliation": "Division of Viral Diseases, Polio and Picornavirus Branch, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America."
},
{
"LastName": "Jeffries Miles",
"FirstName": "Stacey",
"Affiliation": "Division of Viral Diseases, Polio and Picornavirus Branch, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America."
},
{
"LastName": "Hill",
"FirstName": "Jamaica",
"Affiliation": "Contracting Agency to the Division of Viral Diseases, IHRC Inc., Atlanta, Georgia, United States of America."
},
{
"LastName": "Mendoza Prillwitz",
"FirstName": "María Linda",
"Affiliation": "Ministerio de Salud Pública y Asistencia Social Guatemala, Guatemala City, Guatemala."
},
{
"LastName": "Gobern",
"FirstName": "Lorena",
"Affiliation": "Ministerio de Salud Pública y Asistencia Social Guatemala, Guatemala City, Guatemala."
},
{
"LastName": "Gaitán",
"FirstName": "Ericka",
"Affiliation": "Ministerio de Salud Pública y Asistencia Social Guatemala, Guatemala City, Guatemala."
},
{
"LastName": "Delgado",
"FirstName": "Andrea Paola",
"Affiliation": "Ministerio de Salud Pública y Asistencia Social Guatemala, Guatemala City, Guatemala."
},
{
"LastName": "Castillo Signor",
"FirstName": "Leticia",
"Affiliation": "Ministerio de Salud Pública y Asistencia Social Guatemala, Guatemala City, Guatemala."
},
{
"LastName": "Rondy",
"FirstName": "Marc",
"Affiliation": "Pan-American Health Organization/World Health Organization, Guatemala Country Office, Guatemala City, Guatemala."
},
{
"LastName": "Rey-Benito",
"FirstName": "Gloria",
"Affiliation": "Pan-American Health Organization, World Health Organization, Washington, DC, United States of America."
},
{
"LastName": "Gerloff",
"FirstName": "Nancy",
"Affiliation": "Division of Viral Diseases, Polio and Picornavirus Branch, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America."
}
] | No |
39030250 | Exploring the therapeutic potential of Aloin: unraveling neuroprotective and anticancer mechanisms, and strategies for enhanced stability and delivery. | We investigate the therapeutic potential of Aloin A and Aloin B, two natural compounds derived from Aloe vera leaves, focusing on their neuroprotective and anticancer properties. The structural differences between these two epimers suggest that they may exhibit distinct pharmacological properties. Our investigations revealed that both epimers are not stable in aqueous solution and tend to degrade rapidly, with their concentration decreasing by over 50% within approximately 12 h. These results underscore the importance of addressing issues such as the need for encapsulation into effective drug delivery systems to enhance stability. ThT fluorescence experiments showed that neither compound was able to inhibit Aβ amyloid aggregation, indicating that other mechanisms may be responsible for their neuroprotective effects. Next, an equimolar mixture of Aloin A and Aloin B demonstrated an ability to inhibit proteasome in tube tests, which is suggestive of potential anticancer properties, in accordance with antiproliferative effects observed in neuroblastoma SH-SY5Y and HeLa cell lines. Higher water stability and increased antiproliferative activity were observed by encapsulation in carbon dot nanoparticles, suggesting a promising potential for further in vivo studies. | 2024 Jul 20 | Scientific reports | No DOI | [
{
"LastName": "Zimbone",
"FirstName": "Stefania",
"Affiliation": "Istituto di Cristallografia - CNR Sede Secondaria di Catania, Via P. Gaifami 18, 95126, Catania, Italy."
},
{
"LastName": "Romanucci",
"FirstName": "Valeria",
"Affiliation": "Department of Chemical Sciences, University of Naples Federico II, Via Cintia 4, 80126, Naples, Italy."
},
{
"LastName": "Zarrelli",
"FirstName": "Armando",
"Affiliation": "Department of Chemical Sciences, University of Naples Federico II, Via Cintia 4, 80126, Naples, Italy."
},
{
"LastName": "Giuffrida",
"FirstName": "Maria Laura",
"Affiliation": "Istituto di Cristallografia - CNR Sede Secondaria di Catania, Via P. Gaifami 18, 95126, Catania, Italy."
},
{
"LastName": "Sciacca",
"FirstName": "Michele F M",
"Affiliation": "Istituto di Cristallografia - CNR Sede Secondaria di Catania, Via P. Gaifami 18, 95126, Catania, Italy."
},
{
"LastName": "Lanza",
"FirstName": "Valeria",
"Affiliation": "Istituto di Cristallografia - CNR Sede Secondaria di Catania, Via P. Gaifami 18, 95126, Catania, Italy."
},
{
"LastName": "Campagna",
"FirstName": "Tiziana",
"Affiliation": "Istituto di Cristallografia - CNR Sede Secondaria di Catania, Via P. Gaifami 18, 95126, Catania, Italy."
},
{
"LastName": "Maugeri",
"FirstName": "Ludovica",
"Affiliation": "Department of Drug Science and Health, University of Catania, 95125, Catania, Italy."
},
{
"LastName": "Petralia",
"FirstName": "Salvatore",
"Affiliation": "Department of Drug Science and Health, University of Catania, 95125, Catania, Italy."
},
{
"LastName": "Consoli",
"FirstName": "Grazia Maria Letizia",
"Affiliation": "Istituto di Chimica Biomolecolare, CNR Sede Secondaria di Catania, Via P. Gaifami 18, 95126, Catania, Italy."
},
{
"LastName": "Di Fabio",
"FirstName": "Giovanni",
"Affiliation": "Department of Chemical Sciences, University of Naples Federico II, Via Cintia 4, 80126, Naples, Italy."
},
{
"LastName": "Milardi",
"FirstName": "Danilo",
"Affiliation": "Istituto di Cristallografia - CNR Sede Secondaria di Catania, Via P. Gaifami 18, 95126, Catania, Italy. [email protected]."
}
] | No |
36209136 | Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington's disease-related phenotype. | Huntington's disease (HD) is a neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein encoded from extra tracts of CAG repeats in exon 1 of the HTT gene. mHTT proteins are neurotoxic to render the death of neurons and a series of disease-associated phenotypes. The mHTT is degraded through autophagy pathway and ubiquitin-proteasome system (UPS). This study identified a small molecule, J3, as an autophagy inducer by high-content screening. The results revealed that J3 could inhibit mTOR, thus promoting autophagic flux and long-lived protein degradation. Further, J3 selectively lowered the soluble and insoluble mHTT but not wild type HTT levels in cell models. The HdhQ140 mice showed reduced HD-associated activity and loss of motor functions. However, administration of J3 showed increased activity and a slight improvement in the motor function in the open-field test, balance beam test, and rotarod tests. Furthermore, in vivo studies revealed that J3 decreased T-HTT and misfolded protein levels in the striatum and increased the levels of the medium spiny neuron marker DARPP-32. In addition, J3 showed good permeability across the brain-blood barrier efficiently, suggesting that J3 was a promising candidate for the treatment of HD. | 2022 Oct 8 | Cell & bioscience | No DOI | [
{
"LastName": "Long",
"FirstName": "Jiahui",
"Affiliation": "School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, National and Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, Guangdong, China."
},
{
"LastName": "Luo",
"FirstName": "Xia",
"Affiliation": "School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, National and Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, Guangdong, China."
},
{
"LastName": "Fang",
"FirstName": "Dongmei",
"Affiliation": "School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, National and Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, Guangdong, China."
},
{
"LastName": "Song",
"FirstName": "Haikun",
"Affiliation": "Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, 511458, Guangdong, China."
},
{
"LastName": "Fang",
"FirstName": "Weibin",
"Affiliation": "School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, National and Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, Guangdong, China."
},
{
"LastName": "Shan",
"FirstName": "Hao",
"Affiliation": "School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, National and Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, Guangdong, China."
},
{
"LastName": "Liu",
"FirstName": "Peiqing",
"Affiliation": "School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, National and Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, Guangdong, China."
},
{
"LastName": "Lu",
"FirstName": "Boxun",
"Affiliation": "School of Life Sciences, Fudan University, Shanghai, 200438, China."
},
{
"LastName": "Yin",
"FirstName": "Xiao-Ming",
"Affiliation": "Department of Pathology and Laboratory Medicine, School of Medicine, Tulane University, New Orleans, LA, 70112, USA. [email protected]."
},
{
"LastName": "Hong",
"FirstName": "Liang",
"Affiliation": "School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, National and Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, Guangdong, China. [email protected]."
},
{
"LastName": "Li",
"FirstName": "Min",
"Affiliation": "School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, National and Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, Guangdong Engineering Laboratory of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, 510006, Guangdong, China. [email protected]."
}
] | No |
31646806 | Comparisons of efficacy and safety between docetaxel + cisplatin and paclitaxel + cisplatin and their effects on serum HE4, CA125 and ROMA indicators in patients with ovarian carcinoma. | To explore the efficacy and safety of docetaxel (DTX) + cisplatin (DDP) and paclitaxel (TAX) + DDP and their effects on serum human epididymis protein 4 (HE4), carbohydrate antigen 125 (CA125) and risk of ovarian malignancy algorithm (ROMA) index in the treatment of ovarian carcinoma. A total of 90 patients admitted and treated in our hospital from February 2017 to June 2018, with definitely diagnosed ovarian carcinoma via pathological biopsy were selected. The included patients were randomly divided into two groups: DTX+DDP group (n=45) and TAX+DDP group (n=45). With 3 weeks as a course, the treatments lasted for 6 consecutive courses. The changes in serum vascular endothelial growth factor (VEGF), matrix metalloproteinase 2 (MMP-2), HE4, CA125 and ROMA index were detected before and after treatments. Moreover, the incidence of adverse reactions was observed, and the clinical therapeutic efficacy was assessed. The clinical efficacy in both groups revealed that there were 39 and 34 cases obtained complete remission or partial remission in the DTX+DDP group and in the TAX+DDP group, respectively. Overall efficiencies were 86.67 and 75.56%, respectively, showing statistically significant differences between the two groups (p<0.05). The incidence rate of adverse reactions in DTX+DDP group was significantly lower than that in TAX+DDP group (p<0.05). The VEGF and MMP-2 levels in both DTX+DDP and TAX+DDP group were decreased compared with those before treatment (183.35±25.26 vs. 279.18±27.75 pg/mL and 228.22±40.21 vs. 316.11±33.6 pg/mL (p<0.05). The serum HE4 and CA125 levels and ROMA index in both groups were lower than those before treatment (121.19±14.14 vs. 159.43±18.15 pmol/L) (p<0.05), 239.45±25.37 vs. 288.37±30.36 pmol/L (p<0.05) and 58.02±6.61 vs. 76.23±11.58 (p<0.05), respectively). The above indicators were decreased in the DTX+DDP group to a significant extent (p<0.05). Both DTX+DDP and TAX+DDP treatments are effective for the patients with ovarian carcinoma. However, DTX+DDP is more efficacious in lowering indicators such as serum CA125, HE4 and MMP-2 and ROMA index and adverse reactions, thus providing a more efficient practice scheme with lower toxic side effects for the clinical treatment of ovarian carcinoma. | 2019 Jul-Aug | Journal of B.U.ON. : official journal of the Balkan Union of Oncology | No DOI | [
{
"LastName": "Han",
"FirstName": "Liwei",
"Affiliation": "Department of Gynecology, Xuzhou Medical University Affiliated Hospital of Lianyungang (The First People's Hospital of Lianyungang), Lianyungang, China."
},
{
"LastName": "Kuang",
"FirstName": "Lei",
"Affiliation": ""
}
] | No |
38401542 | Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation. | Most eukaryotic proteins are degraded by the 26S proteasome after modification with a polyubiquitin chain. Substrates lacking unstructured segments cannot be degraded directly and require prior unfolding by the Cdc48 ATPase (p97 or VCP in mammals) in complex with its ubiquitin-binding partner Ufd1-Npl4 (UN). Here, we use purified yeast components to reconstitute Cdc48-dependent degradation of well-folded model substrates by the proteasome. We show that a minimal system consists of the 26S proteasome, the Cdc48-UN ATPase complex, the proteasome cofactor Rad23, and the Cdc48 cofactors Ubx5 and Shp1. Rad23 and Ubx5 stimulate polyubiquitin binding to the 26S proteasome and the Cdc48-UN complex, respectively, allowing these machines to compete for substrates before and after their unfolding. Shp1 stimulates protein unfolding by the Cdc48-UN complex rather than substrate recruitment. Experiments in yeast cells confirm that many proteins undergo bidirectional substrate shuttling between the 26S proteasome and Cdc48 ATPase before being degraded. | 2024 Apr 4 | Molecular cell | No DOI | [
{
"LastName": "Li",
"FirstName": "Hao",
"Affiliation": "Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA."
},
{
"LastName": "Ji",
"FirstName": "Zhejian",
"Affiliation": "Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA."
},
{
"LastName": "Paulo",
"FirstName": "Joao A",
"Affiliation": "Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA."
},
{
"LastName": "Gygi",
"FirstName": "Steven P",
"Affiliation": "Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA."
},
{
"LastName": "Rapoport",
"FirstName": "Tom A",
"Affiliation": "Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. Electronic address: [email protected]."
}
] | No |
32674957 | Safety Considerations for Cerebellar Theta Burst Stimulation. | The cerebellum is an intricate neural structure that orchestrates various cognitive and behavioral functions. In recent years, there has been an increasing interest in neuromodulation of the cerebellum with transcranial magnetic stimulation (TMS) for therapeutic and basic science applications. Theta burst stimulation (TBS) is an efficient and powerful TMS protocol that is able to induce longer-lasting effects with shorter stimulation times compared with traditional TMS. Parameters for cerebellar TBS are traditionally framed in the bounds of TBS to the cerebral cortex, even when the 2 have distinct histologic, anatomical, and functional characteristics. Tolerability limits have not been systematically explored in the literature for this specific application. Therefore, we aimed to determine the stimulation parameters that have been used for cerebellar. TBS to date and evaluate adverse events and adverse effects related to stimulation parameters. We used PubMed to perform a critical review of the literature based on a systematic review of original research studies published between September 2008 and November 2019 that reported on cerebellar TBS. We recovered information from these publications and communication with authors about the stimulation parameters used and the occurrence of adverse events. We identified 61 research articles on interventions of TBS to the cerebellum. These articles described 3176 active sessions of cerebellar TBS in 1203 individuals, including healthy participants and patients with various neurologic conditions, including brain injuries. Some studies used substantial doses (eg, pulse intensity and number of pulses) in short periods. No serious adverse events were reported. The specific number of patients who experienced adverse events was established for 48 studies. The risk of an adverse event in this population (n = 885) was 4.1%. Adverse events consisted mostly of discomfort attributable to involuntary muscle contractions. Authors used a variety of methods for calculating stimulation dosages, ranging from the long-established reference of electromyography of a hand muscle to techniques that atone for some of the differences between cerebrum and cerebellum. No serious adverse events have been reported for cerebellar TBS. There is no substantial evidence of a tolerable maximal-efficacy stimulation dose in humans. There is no assurance of equivalence in the translation of cortical excitability and stimulation intensities from the cerebral cortex to cerebellar regions. Further research for the stimulation dose in cerebellar TBS is warranted, along with consistent report of adverse events. © 2020 Elsevier HS Journals, Inc. | 2020 Jul | Clinical therapeutics | No DOI | [
{
"LastName": "Hurtado-Puerto",
"FirstName": "Aura M",
"Affiliation": "Laboratory of Neuropsychiatry and Neuromodulation, Massachusetts General Hospital, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; Centro de Estudios Cerebrales, Facultad de Ciencias, Universidad del Valle, Cali, Colombia. Electronic address: [email protected]."
},
{
"LastName": "Nestor",
"FirstName": "Kimberly",
"Affiliation": "Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."
},
{
"LastName": "Eldaief",
"FirstName": "Mark",
"Affiliation": "Laboratory of Neuropsychiatry and Neuromodulation, Massachusetts General Hospital, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."
},
{
"LastName": "Camprodon",
"FirstName": "Joan A",
"Affiliation": "Laboratory of Neuropsychiatry and Neuromodulation, Massachusetts General Hospital, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."
}
] | No |
38421003 | Design, synthesis, in vitro and in vivo biological evaluation of pterostilbene derivatives for anti-inflammation therapy. | Pterostilbene (PST) is a naturally derived stilbene compound in grapes, blueberries, and other fruits. It is also a natural dietary compound with a wide range of biological activities such as antioxidant, anti-inflammatory, antitumor, and so on. Structural modifications based on the chemical scaffold of the pterostilbene skeleton are of great importance for drug discovery. In this study, pterostilbene skeletons were used to design novel anti-inflammatory compounds with high activity and low toxicity. A total of 30 new were found and synthesised, and their anti-inflammatory activity and safety were screened. Among them, compound E2 was the most active (against NO: IC50 = 0.7 μM) than celecoxib. Further studies showed that compound E2 exerted anti-inflammatory activity by blocking LPS-induced NF-κB/MAPK signalling pathway activation. In vivo experiments revealed that compound E2 had a good alleviating effect on acute colitis in mice. In conclusion, compound E2 may be a promising anti-inflammatory lead compound. | 2024 Dec | Journal of enzyme inhibition and medicinal chemistry | No DOI | [
{
"LastName": "Chen",
"FirstName": "Liuzeng",
"Affiliation": "School of Biology, Food and Environment, Hefei University, Hefei, P. R. China."
},
{
"LastName": "Wang",
"FirstName": "Ke",
"Affiliation": "School of Biology, Food and Environment, Hefei University, Hefei, P. R. China."
},
{
"LastName": "Liu",
"FirstName": "Xiaohan",
"Affiliation": "School of Biology, Food and Environment, Hefei University, Hefei, P. R. China."
},
{
"LastName": "Wang",
"FirstName": "Lifan",
"Affiliation": "School of Biology, Food and Environment, Hefei University, Hefei, P. R. China."
},
{
"LastName": "Zou",
"FirstName": "Hui",
"Affiliation": "School of Biology, Food and Environment, Hefei University, Hefei, P. R. China."
},
{
"LastName": "Hu",
"FirstName": "Shuying",
"Affiliation": "School of Biology, Food and Environment, Hefei University, Hefei, P. R. China."
},
{
"LastName": "Zhou",
"FirstName": "Lingling",
"Affiliation": "School of Biology, Food and Environment, Hefei University, Hefei, P. R. China."
},
{
"LastName": "Li",
"FirstName": "Rong",
"Affiliation": "School of Biology, Food and Environment, Hefei University, Hefei, P. R. China."
},
{
"LastName": "Cao",
"FirstName": "Shiying",
"Affiliation": "School of Biology, Food and Environment, Hefei University, Hefei, P. R. China."
},
{
"LastName": "Ruan",
"FirstName": "Banfeng",
"Affiliation": "School of Biology, Food and Environment, Hefei University, Hefei, P. R. China."
},
{
"LastName": "Cui",
"FirstName": "Quanren",
"Affiliation": "Institute of Tobacoo Research, Anhui Academy of Agricultural Sciences, Hefei, P. R. China."
}
] | No |
37007986 | Self-Assembling Lecithin-Based Mixed Polymeric Micelles for Nose to Brain Delivery of Clozapine: In-vivo Assessment of Drug Efficacy via Radiobiological Evaluation. | The research objective is to design intranasal brain targeted CLZ loaded lecithin based polymeric micelles (CLZ- LbPM) aiming to improve central systemic CLZ bioavailability. In our study, intranasal CLZ loaded lecithin based polymeric micelles (CLZ- LbPM) were formulated using soya phosphatidyl choline (SPC) and sodium deoxycholate (SDC) with different CLZ:SPC:SDC ratios via thin film hydration technique aiming to enhance drug solubility, bioavailability and nose to brain targeting efficiency. Optimization of the prepared CLZ-LbPM using Design-Expert® software was achieved showing that M6 which composed of (CLZ:SPC: SDC) in respective ratios of 1:3:10 was selected as the optimized formula. The optimized formula was subjected to further evaluation tests as, Differential Scanning Calorimetry (DSC), TEM, in vitro release profile, ex vivo intranasal permeation and in vivo biodistribution. The optimized formula with the highest desirability exhibiting (0.845), small particle size (12.23±4.76 nm), Zeta potential of (-38 mV), percent entrapment efficiency of > 90% and percent drug loading of 6.47%. Ex vivo permeation test showed flux value of 27 μg/cm².h and the enhancement ratio was about 3 when compared to the drug suspension, without any histological alteration. The radioiodinated clozapine ([[131]I] iodo-CLZ) and radioiodinated optimized formula ([[131]I] iodo-CLZ-LbPM) were formulated in an excellent radioiodination yield more than 95%. In vivo biodistribution studies of [[131]I] iodo-CLZ-LbPM showed higher brain uptake (7.8%± 0.1%ID/g) for intranasal administration with rapid onset of action (at 0.25 h) than the intravenous formula. Its pharmacokinetic behavior showed relative bioavailability, direct transport percentage from nose to brain and drug targeting efficiency of 170.59%, 83.42% and 117% respectively. The intranasal self-assembling lecithin based mixed polymeric micelles could be an encouraging way for CLZ brain targeting. | 2023 | International journal of nanomedicine | No DOI | [
{
"LastName": "M Elsharkawy",
"FirstName": "Fatma",
"Affiliation": "Regulatory Affairs Department, Al Andalous for Pharmaceutical Industries, Giza, Egypt."
},
{
"LastName": "M Amin",
"FirstName": "Maha",
"Affiliation": "Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt."
},
{
"LastName": "A Shamsel-Din",
"FirstName": "Hesham",
"Affiliation": "Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt."
},
{
"LastName": "Ibrahim",
"FirstName": "Walaa",
"Affiliation": "Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt."
},
{
"LastName": "Ibrahim",
"FirstName": "Ahmed B",
"Affiliation": "Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt."
},
{
"LastName": "Sayed",
"FirstName": "Sinar",
"Affiliation": "Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt."
}
] | No |
37870765 | STK4 is a prognostic biomarker correlated with immune infiltrates in clear cell renal cell carcinoma. | Mammalian STE20-like kinase 1 (MST1/STK4/KRS2) is a highly conserved serine/threonine kinase and a central member of the Hippo signaling pathway. STK4 has been reported to play important roles in various tumors, but a systematic and comprehensive study of its function in clear cell renal cell carcinoma (ccRCC) has not been conducted. In this study, we used immunohistochemistry (IHC), western blot (WB), quantitative real-time PCR (qPCR) experiments, and bioinformatics analysis to comprehensively analyze the expression, prognostic value, and immune infiltration of STK4 in ccRCC. Analysis of the TCGA database showed that the expression level of the STK4 gene in ccRCC patients depended on tumor stage, grade, and distant lymphatic metastasis. This was further confirmed by the results of IHC, WB, and qPCR. In addition, we used the receiver operating characteristic curve (ROC curve) to elucidate the diagnostic value of STK4 in ccRCC patients. According to the findings of the TIMER database, the high expression of STK4 is significantly associated with the survival of kidney cancer (including ccRCC) patients (p < 0.001), suggesting that STK4 is a reliable prognostic predictor. We then used gene set enrichment analysis (GSEA) to explore the mechanisms behind STK4 function in ccRCC. We found that STK4 may play a role in immune regulation interactions. Subsequently, we performed immune infiltration analysis of STK4. The results showed that STK4 may regulate the development of ccRCC by affecting the immune infiltration of NK and pDC cells. STK4 may be a prognostic marker for ccRCC and may help identify new strategies for treating ccRCC patients. | 2023 Oct 20 | Aging | No DOI | [
{
"LastName": "Bai",
"FirstName": "Zi-Yuan",
"Affiliation": "Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China."
},
{
"LastName": "Peng",
"FirstName": "Lu-Shan",
"Affiliation": "Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China."
},
{
"LastName": "Li",
"FirstName": "Run-Qi",
"Affiliation": "School of Basic Medicine, Central South University, Changsha 410031, Hunan, China."
},
{
"LastName": "Peng",
"FirstName": "Xianchu",
"Affiliation": "School of Basic Medicine, Central South University, Changsha 410031, Hunan, China."
},
{
"LastName": "Yang",
"FirstName": "Zhe",
"Affiliation": "Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China."
}
] | No |
24839363 | Effect of Antiviral Prophylaxis Strategy for Chemotherapy-Associated Hepatitis B Reactivation in Non-Hodgkin's Lymphoma Patients with Hepatitis B Virus Infection: A Retrospective Cohort Study. | Recent data indicates that nucleoside/nucleotide analogue (NUC) is effective in preventing and controlling hepatitis B virus (HBV) reactivation in HBV-carrying cancer patients who undergo chemotherapy, but the ideal antiviral agent and optimal application protocol still needs to be determined. Meanwhile, it is uncertain whether those with past HBV infection require antiviral prophylaxis during chemotherapy. This report retrospectively analyzed non-Hodgkin's lymphoma (NHL) patients seen from January, 2004 to June, 2009 in West China Hospital. We found that the prevalence of chronic HBV infection in our NHL patients was 20.7 % while that of past HBV infection was 21.05 %. Compared with the high rate (25.6 %) of HBV reactivation in patients with chronic HBV infection, none of those with past HBV infection in fact had occult HBV infection thus none experienced reactivation. Of the 82 patients with chronic HBV infection who received chemotherapy, antiviral prophylaxis could significantly reduce the incidence of HBV reactivation (5.0 vs. 45.2 % in the control group) and the incidence of liver function damage (32.5 vs. 73.8 % in the control group). The results of the current study confirmed previous reports that prophylactic NUCs administration can effectively prevent HBV reactivation and significantly reduce the incidence of HBV reactivation especially for patients receiving rituximab-containing regimens. Due to the fact that none of individuals who had past HBV infection developed HBV reactivation reported in our study, antiviral prophylaxis may not be required for patients with past HBV infection. Close observation of alanine aminotransferase and HBV-DNA contributes to early diagnosis and timely treatment of HBV reactivation. | 2014 Jun | Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion | No DOI | [
{
"LastName": "Yang",
"FirstName": "Fan",
"Affiliation": "West China School of Clinical Medicine, Sichuan University, No. 37 Guoxue Alley, Chengdu, China."
},
{
"LastName": "Zhu",
"FirstName": "Huan-Ling",
"Affiliation": "Department of Haematology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, China."
},
{
"LastName": "He",
"FirstName": "Chuan",
"Affiliation": "Department of Haematology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, China."
},
{
"LastName": "Li",
"FirstName": "Jian-Jun",
"Affiliation": "Department of Haematology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, China."
},
{
"LastName": "Xiang",
"FirstName": "Bing",
"Affiliation": "Department of Haematology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, China."
},
{
"LastName": "Cui",
"FirstName": "Xu",
"Affiliation": "Department of Haematology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, China."
},
{
"LastName": "Huang",
"FirstName": "Jie",
"Affiliation": "Department of Haematology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, China."
},
{
"LastName": "Ji",
"FirstName": "Jie",
"Affiliation": "Department of Haematology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, China."
},
{
"LastName": "Ma",
"FirstName": "Hong-Bing",
"Affiliation": "Department of Haematology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, China."
},
{
"LastName": "Liu",
"FirstName": "Ting",
"Affiliation": "Department of Haematology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, China."
}
] | No |
38240368 | Asthma prevalence among US 9th-12th graders who report past 30-day cannabis use in 2019. | Little is known about the relationship between cannabis use and asthma among youth in the US. The aims of this study were to estimate prevalence of asthma among youth who reported any cannabis use in the past 30 days, relative to those who did not, and to investigate the relationship between frequency of cannabis use and prevalence of asthma, adjusting for demographic characteristics and cigarette use. Data were drawn from the 2019 Youth Risk Behavior Surveillance System (YRBSS), a CDC national high school survey, which collects data from students in grades 9-12 across the US bi-annually. Logistic regression was used to examine the prevalence of asthma among youth who reported any past 30-day cannabis use, relative to no use, and by frequency of cannabis use, adjusting for demographic characteristics and cigarette use. Asthma was more common among youth who reported any cannabis use, relative to youth who reported no use (29.07% vs. 23.62%; AOR = 1.25 (1.20, 1.30)). Asthma was greater among youth who reported more frequent cannabis use; asthma was highest among youth who reported having used cannabis "40 or more times" in the month (31.38%; AOR = 1.35 (1.25, 1.45)) CONCLUSION: Asthma is more common among youth who use cannabis, relative to those who do not, and the prevalence of asthma increases with frequency of use among 9th-12th graders in the US. More public health and clinical research is needed quickly to produce scientific data that can inform clinical guidelines and public health policy, as well as parents and youth, on the potential relationship between cannabis use and respiratory health among youth. | 2024 Apr | Pediatric pulmonology | No DOI | [
{
"LastName": "Silverman",
"FirstName": "Kevin D",
"Affiliation": "Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, The City University of New York, New York, New York, USA."
},
{
"LastName": "Cheslack-Postava",
"FirstName": "Keely",
"Affiliation": "New York State Psychiatric Institute, New York, New York, USA."
},
{
"LastName": "Rastogi",
"FirstName": "Deepa",
"Affiliation": "Department of Pediatrics, George Washington University School of Medicine, Washington, District of Columbia, USA."
},
{
"LastName": "Borrell",
"FirstName": "Luisa N",
"Affiliation": "Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, The City University of New York, New York, New York, USA."
},
{
"LastName": "Goodwin",
"FirstName": "Renee D",
"Affiliation": "Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, The City University of New York, New York, New York, USA."
}
] | No |
2214028 | Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites. | The integration protein (IN) of Moloney murine leukemia virus (MuLV), purified after being produced in yeast cells, has been analyzed for its ability to bind its putative viral substrates, the att sites. An electrophoretic mobility shift assay revealed that the Moloney MuLV IN protein binds synthetic oligonucleotides containing att sequences, with specificity towards its cognate (MuLV) sequences. The terminal 13 base pairs, which are identical at both ends of viral DNA, are sufficient for binding if present at the ends of oligonucleotide duplexes in the same orientation as in linear viral DNA. However, only weak binding was observed when the same sequences were positioned within a substrate in a manner simulating att junctions in circular viral DNA with two long terminal repeats. Binding to att sites in oligonucleotides simulating linear viral DNA was dependent on the presence of the highly conserved CA residues preceding the site for 3' processing (an IN-dependent reaction that removes two nucleotides from the 3' ends of linear viral DNA); mutation of CA to TG abolished binding, and a CA to TA change reduced affinity by at least 20-fold. Removal of either the terminal two base pairs from both ends of the oligonucleotide duplex or the terminal two nucleotides from the 3' ends of each strand did not affect binding. The removal of three 3' terminal nucleotides, however, abolished binding, suggesting an essential role for the A residue immediately upstream of the 3' processing site in the binding reaction. These results help define the sequence requirements for att site recognition by IN, explain the conservation of the subterminal CA dinucleotide, and provide a simple assay for sequence-specific IN activity. | 1990 Nov | Journal of virology | No DOI | [
{
"LastName": "Basu",
"FirstName": "S",
"Affiliation": "Department of Microbiology and Immunology, University of California, San Francisco 94143."
},
{
"LastName": "Varmus",
"FirstName": "H E",
"Affiliation": ""
}
] | Yes |
35320035 | Transendocardial CD34(+) Cell Therapy Improves Local Mechanical Dyssynchrony in Patients With Nonischemic Dilated Cardiomyopathy. | We investigated the effects of cell therapy on local mechanical dyssynchrony (LMD) in patients with nonischemic dilated cardiomyopathy (NICM). We analyzed electromechanical data of 30 NICM patients undergoing CD34[+] cell transplantation. All patients underwent bone marrow stimulation; CD34[+] cells were collected by apheresis and injected transendocardially. At baseline and at 6 months after therapy, we performed electromechanical mapping and measured unipolar voltage (UV) and LMD at cell injection sites. LMD was defined as a temporal difference between global and segmental peak systolic displacement normalized to the average duration of the RR interval. Favorable clinical response was defined as increase in the left ventricular ejection fraction (LVEF) ≥5% between baseline and 6 months. Using paired electromechanical point-by-point analysis, we were able to identify 233 sites of CD34[+] cell injections in 30 patients. We found no overall differences in local UV between baseline and 6 months (10.7 ± 4.1 mV vs 10.0 ± 3.6 mV, P = 0.42). In contrast, LMD decreased significantly (17 ± 17% at baseline vs 13 ± 12% at 6 months, P = 0.00007). Favorable clinical response at 6 months was found in 19 (63%) patients (group A), and 11 (37%) patients did not respond to cell therapy (group B). At baseline, the two groups did not differ in age, gender, LVEF, or N terminal-pro brain natriuretic peptide (NT-proBNP) levels. Similarly, we found no differences in baseline UV (9.5 ± 2.9 mV in group A vs 8.6 ± 2.4 mV in group B, P = 0.41) or LMD at cell injection sites (17 ± 19% vs 16 ± 14%, P = 0.64). In contrast, at 6 months, we found higher UV in group A (10.0 ± 3.1 mV vs 7.4 ± 1.9 mV in group B, P = 0.04). Furthermore, when compared with group B, patients in group A displayed a significantly lower LMD (11 ± 12% vs 16 ± 10%, P = 0.002). Thus, it appears that favorable clinical effects of cell therapy in NICM patients may be associated with a decrease of LMD at cell injection sites. | 2022 Jan-Dec | Cell transplantation | No DOI | [
{
"LastName": "Žorž",
"FirstName": "Neža",
"Affiliation": "Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia."
},
{
"LastName": "Poglajen",
"FirstName": "Gregor",
"Affiliation": "Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia."
},
{
"LastName": "Frljak",
"FirstName": "Sabina",
"Affiliation": "Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia."
},
{
"LastName": "Knezevič",
"FirstName": "Ivan",
"Affiliation": "Department of Cardiovascular Surgery, University Medical Center Ljubljana, Ljubljana, Slovenia."
},
{
"LastName": "Vrtovec",
"FirstName": "Bojan",
"Affiliation": "Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia."
}
] | No |
31642074 | K-Ras-PI3K regulates H3K56ac through PCAF to elevate the occurrence and growth of liver cancer. | H3 modification is related to a wide range of tumors, including liver cancer. The Ras passageway is actuated in human diseases. Thus, we investigated the roles of Ras in liver cancer cells via acetylation of H3K56. Ras-carrying G12V and Y40C site mutation was transfected into liver cancer cell lines SNU-475 and SK-Hep-1. Acetylation of H3K56 and phosphatidylinositol 3-kinase (PI3K), P300/CBP-associated factor (PCAF) and Mouse double minute 2 homolog (MDM2) was tested via western blot. Cell activity, colonies, and migration were tested via Cell Counting Kit-8, soft-agar colony formation, and Transwell experiment, respectively. Sirtuin 6 (SIRT6) and PCAF were tested via quantitative reverse transcription polymerase chain reaction (qRT-PCR). Chromatin immunoprecipitation was employed to test the relationship between Ras and downstream elements. Flow cytometry was employed to test cell cycle series. We found that Ras[G12V/Y40C] transfection reduced the acetylation of H3K56 and activated phosphorylation of protein kinase B. H3K56Q (H3K56ac overexpression) suppressed cell activity, colonies, and migration. H3K56ac changed Ras downstream factors expression. Ras[G12V/Y40C] bound to Ras-PI3K downstream elements' promoters. SIRT6 silencing raised H3K56ac and suppressed cell activity, migration and S phage cell percentage. SIRT6 silence transformed expression of downstream elements. PCAF and H3K56ac demonstrated the close current while MDM2 was conversed. In summary, the Ras-PI3K passageway promoted cell growth and metastasis via decreasing H3K56ac, in which MDM2-mediated PCAF was involved. | 2020 Apr | Journal of cellular physiology | No DOI | [
{
"LastName": "Gao",
"FirstName": "Xianrui",
"Affiliation": "Department of General Surgery, Juancheng People's Hospital, Heze, China."
},
{
"LastName": "Cheng",
"FirstName": "Zhaoling",
"Affiliation": "Department of Gastroenterology, Heze Municipal Hospital, Heze, China."
},
{
"LastName": "Yuan",
"FirstName": "Haifeng",
"Affiliation": "Department of Gastroenterology, Heze Municipal Hospital, Heze, China."
},
{
"LastName": "Zhao",
"FirstName": "Haiwang",
"Affiliation": "Department of Hepatobiliary Surgery, Heze Municipal Hospital, Heze, China."
}
] | Yes |
30694690 | Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion. | Pancreatic α-cells exhibit oscillations in cytosolic Ca[2+] (Ca[2+]c), which control pulsatile glucagon (GCG) secretion. However, the mechanisms that modulate α-cell Ca[2+]c oscillations have not been elucidated. As β-cell Ca[2+]c oscillations are regulated in part by Ca[2+]-activated K[+] (Kslow) currents, this work investigated the role of Kslow in α-cell Ca[2+] handling and GCG secretion. α-Cells displayed Kslow currents that were dependent on Ca[2+] influx through L- and P/Q-type voltage-dependent Ca[2+] channels (VDCCs) as well as Ca[2+] released from endoplasmic reticulum stores. α-Cell Kslow was decreased by small-conductance Ca[2+]-activated K[+] (SK) channel inhibitors apamin and UCL 1684, large-conductance Ca[2+]-activated K[+] (BK) channel inhibitor iberiotoxin (IbTx), and intermediate-conductance Ca[2+]-activated K[+] (IK) channel inhibitor TRAM 34. Moreover, partial inhibition of α-cell Kslow with apamin depolarized membrane potential (Vm) (3.8 ± 0.7 mV) and reduced action potential (AP) amplitude (10.4 ± 1.9 mV). Although apamin transiently increased Ca[2+] influx into α-cells at low glucose (42.9 ± 10.6%), sustained SK (38.5 ± 10.4%) or BK channel inhibition (31.0 ± 11.7%) decreased α-cell Ca[2+] influx. Total α-cell Ca[2+]c was similarly reduced (28.3 ± 11.1%) following prolonged treatment with high glucose, but it was not decreased further by SK or BK channel inhibition. Consistent with reduced α-cell Ca[2+]c following prolonged Kslow inhibition, apamin decreased GCG secretion from mouse (20.4 ± 4.2%) and human (27.7 ± 13.1%) islets at low glucose. These data demonstrate that Kslow activation provides a hyperpolarizing influence on α-cell Vm that sustains Ca[2+] entry during hypoglycemic conditions, presumably by preventing voltage-dependent inactivation of P/Q-type VDCCs. Thus, when α-cell Ca[2+]c is elevated during secretagogue stimulation, Kslow activation helps to preserve GCG secretion. | 2019 Apr 1 | American journal of physiology. Endocrinology and metabolism | No DOI | [
{
"LastName": "Dickerson",
"FirstName": "Matthew T",
"Affiliation": "Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee."
},
{
"LastName": "Dadi",
"FirstName": "Prasanna K",
"Affiliation": "Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee."
},
{
"LastName": "Altman",
"FirstName": "Molly K",
"Affiliation": "Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee."
},
{
"LastName": "Verlage",
"FirstName": "Kenneth R",
"Affiliation": "Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee."
},
{
"LastName": "Thorson",
"FirstName": "Ariel S",
"Affiliation": "Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee."
},
{
"LastName": "Jordan",
"FirstName": "Kelli L",
"Affiliation": "Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee."
},
{
"LastName": "Vierra",
"FirstName": "Nicholas C",
"Affiliation": "Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee."
},
{
"LastName": "Amarnath",
"FirstName": "Gautami",
"Affiliation": "Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee."
},
{
"LastName": "Jacobson",
"FirstName": "David A",
"Affiliation": "Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee."
}
] | No |
22142751 | Miscellaneous non-inflammatory musculoskeletal conditions. Hyperphosphatemic familial tumoral calcinosis (FGF23, GALNT3 and αKlotho). | Familial tumoral calcinosis (TC) is a rare disorder distinguished by the development of ectopic and vascular calcified masses that occur in settings of hyperphosphatemia (hFTC) and normophosphatemia (nFTC). Serum phosphorus concentrations are relatively tightly controlled by interconnected endocrine activity at the level of the intestine, kidney, and skeleton. Discovering the molecular causes for heritable forms of hFTC has shed new light on the regulation of serum phosphate balance. This review will focus upon the genetic basis and clinical approaches for hFTC, due to genes that are related to the phosphaturic hormone fibroblast growth factor-23 (FGF23). These include FGF23 itself, an FGF23-glycosylating enzyme (GALNT3), and the FGF23 co-receptor α-Klotho (αKL). Our understanding of the molecular basis of hFTC will, in the short term, aid in understanding normal phosphate balance, and in the future, provide potential insight into the design of novel therapeutic strategies for both rare and common disorders of phosphate metabolism. | 2011 Oct | Best practice & research. Clinical rheumatology | No DOI | [
{
"LastName": "Farrow",
"FirstName": "Emily G",
"Affiliation": "Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, Indianapolis, IN 46202, USA."
},
{
"LastName": "Imel",
"FirstName": "Erik A",
"Affiliation": ""
},
{
"LastName": "White",
"FirstName": "Kenneth E",
"Affiliation": ""
}
] | No |
18628906 | The complete mitochondrial genome of yarrowia lipolytica. | We here report the complete nucleotide sequence of the 47.9 kb mitochondrial (mt) genome from the obligate aerobic yeast Yarrowia lipolytica. It encodes, all on the same strand, seven subunits of NADH: ubiquinone oxidoreductase (ND1-6, ND4L), apocytochrome b (COB), three subunits of cytochrome oxidase (COX1, 2, 3), three subunits of ATP synthetase (ATP6, 8 and 9), small and large ribosomal RNAs and an incomplete set of tRNAs. The Y. lipolytica mt genome is very similar to the Hansenula wingei mt genome, as judged from blocks of conserved gene order and from sequence homology. The extra DNA in the Y. lipolytica mt genome consists of 17 group 1 introns and stretches of A+Trich sequence, interspersed with potentially transposable GC clusters. The usual mould mt genetic code is used. Interestingly, there is no tRNA able to read CGN (arginine) codons. CGN codons could not be found in exonic open reading frames, whereas they do occur in intronic open reading frames. However, several of the intronic open reading frames have accumulated mutations and must be regarded as pseudogenes. We propose that this may have been triggered by the presence of untranslatable CGN codons. This sequence is available under EMBL Accession No. AJ307410. | 2001 | Comparative and functional genomics | No DOI | [
{
"LastName": "Kerscher",
"FirstName": "S",
"Affiliation": "Universitätsklinikum Frankfurt, Institut für Biochemie I, Zentrum der Biologischen Chemie, Frankfurt am Main D-60590, Germany. [email protected]"
},
{
"LastName": "Durstewitz",
"FirstName": "G",
"Affiliation": ""
},
{
"LastName": "Casaregola",
"FirstName": "S",
"Affiliation": ""
},
{
"LastName": "Gaillardin",
"FirstName": "C",
"Affiliation": ""
},
{
"LastName": "Brandt",
"FirstName": "U",
"Affiliation": ""
}
] | No |
35507224 | Multifaceted role of natural sources for COVID-19 pandemic as marine drugs. | COVID-19, which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread over the world, posing a global health concern. The ongoing epidemic has necessitated the development of novel drugs and potential therapies for patients infected with SARS-CoV-2. Advances in vaccination and medication development, no preventative vaccinations, or viable therapeutics against SARS-CoV-2 infection have been developed to date. As a result, additional research is needed in order to find a long-term solution to this devastating condition. Clinical studies are being conducted to determine the efficacy of bioactive compounds retrieved or synthesized from marine species starting material. The present study focuses on the anti-SARS-CoV-2 potential of marine-derived phytochemicals, which has been investigated utilizing in in silico, in vitro, and in vivo models to determine their effectiveness. Marine-derived biologically active substances, such as flavonoids, tannins, alkaloids, terpenoids, peptides, lectins, polysaccharides, and lipids, can affect SARS-CoV-2 during the viral particle's penetration and entry into the cell, replication of the viral nucleic acid, and virion release from the cell; they can also act on the host's cellular targets. COVID-19 has been proven to be resistant to several contaminants produced from marine resources. This paper gives an overview and summary of the various marine resources as marine drugs and their potential for treating SARS-CoV-2. We discussed at numerous natural compounds as marine drugs generated from natural sources for treating COVID-19 and controlling the current pandemic scenario. | 2022 Jul | Environmental science and pollution research international | No DOI | [
{
"LastName": "Rahman",
"FirstName": "Md Mominur",
"Affiliation": "Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh."
},
{
"LastName": "Islam",
"FirstName": "Md Rezaul",
"Affiliation": "Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh."
},
{
"LastName": "Shohag",
"FirstName": "Sheikh",
"Affiliation": "Department of Biochemistry and Molecular Biology, Faculty of Life Science, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj-8100, Gopalganj, Bangladesh."
},
{
"LastName": "Hossain",
"FirstName": "Md Emon",
"Affiliation": "Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh."
},
{
"LastName": "Shah",
"FirstName": "Muddaser",
"Affiliation": "Department of Botany, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan."
},
{
"LastName": "Shuvo",
"FirstName": "Shakil Khan",
"Affiliation": "Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh."
},
{
"LastName": "Khan",
"FirstName": "Hosneara",
"Affiliation": "Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh."
},
{
"LastName": "Chowdhury",
"FirstName": "Md Arifur Rahman",
"Affiliation": "Department of Pharmacy, Southeast University, Banani, Dhaka, 1213, Bangladesh."
},
{
"LastName": "Bulbul",
"FirstName": "Israt Jahan",
"Affiliation": "Department of Pharmacy, Southeast University, Banani, Dhaka, 1213, Bangladesh."
},
{
"LastName": "Hossain",
"FirstName": "Md Sarowar",
"Affiliation": "Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh."
},
{
"LastName": "Sultana",
"FirstName": "Sharifa",
"Affiliation": "Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh."
},
{
"LastName": "Ahmed",
"FirstName": "Muniruddin",
"Affiliation": "Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh."
},
{
"LastName": "Akhtar",
"FirstName": "Muhammad Furqan",
"Affiliation": "Riphah Institute of Pharmaceutical Sciences, Riphah International University Lahore Campus, Lahore, Pakistan."
},
{
"LastName": "Saleem",
"FirstName": "Ammara",
"Affiliation": "Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan."
},
{
"LastName": "Rahman",
"FirstName": "Md Habibur",
"Affiliation": "Department of Pharmacy, Southeast University, Banani, Dhaka, 1213, Bangladesh. [email protected]."
}
] | Yes |
18693249 | Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells. | In endothelial cells, the AMP-activated protein kinase (AMPK) is stimulated by sheer stress or growth factors that stimulate release of nitric oxide (NO). We hypothesized that NO might act as an endogenous activator of AMPK in endothelial cells. Exposure of human umbilical vein endothelial cells (HUVECs) to NO donors caused an increase in phosphorylation of both Thr-172 of AMPK and Ser-1177 of endothelial nitric oxide synthase, a downstream enzyme of AMPK. NO-induced activation of AMPK was not affected by inhibition of LKB1, an AMPK kinase. In contrast, inhibition of calcium calmodulin-dependent protein kinase kinase abolished the effect of NO in HUVECs. NO-induced AMPK activation in HeLa S3 cells was abolished by either 1H-(1,2,4)-oxadiazole[4,3-a]quinoxalon-1-one, a potent inhibitor for guanylyl cyclase, or 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis (acetoxymethyl ester) (BAPTA-AM), an intracellular Ca(2+) chelator, indicating that NO-induced AMPK activation is guanylyl cyclase-mediated and calcium-dependent. Exposure of HUVECs or isolated mice aortas to either calcium ionophore A23187 or bradykinin significantly increased AMPK Thr-172 phosphorylation, which was abolished by N-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase. Finally, A23187- or bradykinin-enhanced AMPK activation was significantly greater in aortas from wild type mice than those in the aortas of endothelial nitric oxide synthase knock-out mice. Taken together, we conclude that NO might act as an endogenous AMPK activator. | 2008 Oct 10 | The Journal of biological chemistry | No DOI | [
{
"LastName": "Zhang",
"FirstName": "Junhua",
"Affiliation": "Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104."
},
{
"LastName": "Xie",
"FirstName": "Zhonglin",
"Affiliation": "Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104."
},
{
"LastName": "Dong",
"FirstName": "Yunzhou",
"Affiliation": "Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104."
},
{
"LastName": "Wang",
"FirstName": "Shuangxi",
"Affiliation": "Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104."
},
{
"LastName": "Liu",
"FirstName": "Chao",
"Affiliation": "Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104."
},
{
"LastName": "Zou",
"FirstName": "Ming-Hui",
"Affiliation": "Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104. Electronic address: [email protected]."
}
] | Yes |
23339761 | Tetraamine-coupled peptides and resulting (99m)Tc-radioligands: an effective route for receptor-targeted diagnostic imaging of human tumors. | The successful application of OctreoScan(®) ([(111)In-DTPA]octreotide) in the diagnosis of sst(2)-expressing neuroendocrine tumors (NETs), on one hand, and the manifestation of peptide receptor targets in a wide range of human cancers, on the other, have synergistically induced a booming emergence of numerous radiolabeled peptide (radiopeptide) probes for tumor diagnosis and therapy in man. Definition of molecular targets and their relation to neoplastic disease has preceded peptide-based radiopharmaceutical design and development. New criteria have been set to safeguard efficient localization of radionuclides on tumor-associated high affinity - low capacity peptide receptor systems. New technical and biological terms, such as specific activity or receptor affinity and internalization, have invaded the Radiopharmacy domain and have irrevocably altered our concept of radiopharmaceutical design. Nonetheless, (99m)Tc remains the gold standard of diagnostic nuclear medicine as a result of ideal nuclear characteristics, cost-effectiveness and wide availability in high purity and high specific activity by means of commercial (99)Mo/(99m)Tc-generators. The evolution of conventional (99m)Tc-perfusion agents into modern state-of-the-art molecular radiopharmaceuticals has been a challenge addressed by several researchers. The present review summarizes recent advances in the development of (99m)Tc-labeled peptides for in vivo targeting of neoplastic disease, and, in particular, those functionalized with acyclic tetraamines. Conclusions on their applicability in non-invasive diagnosis and staging of cancer patients are drawn. | 2012 | Current topics in medicinal chemistry | No DOI | [
{
"LastName": "Nock",
"FirstName": "Berthold",
"Affiliation": "Molecular Radiopharmacy, INRASTES, National Center for Scientific Research Demokritos, 15310 Athens, Greece."
},
{
"LastName": "Maina",
"FirstName": "Theodosia",
"Affiliation": ""
}
] | No |
37565518 | Multiple forms of cell death: A focus on the PI3K/AKT pathway. | Cell death is a natural biological process that occurs in living organisms. Since 1963, extensive research has shed light on the occurrence, progress, and final outcome of cell death. According to different cell phenotypes, it is classified into different types, including apoptosis, pyroptosis, necroptosis, autophagy, ferroptosis, cuproptosis, and so on. However, regardless of the form of cell death, what we ultimately expect is the disappearance of abnormal cells, such as tumor cells, while normal cells survive. As a result, it is vital to investigate the details of cell death, including death triggers, potent regulators, and executioners. Although significant progress has been made in understanding molecular pathways of cell death, many aspects remain unclear because of the complex regulatory networks in cells. Among them, the phosphoinositide-3-kinase (PI3K)/protein kinase B(AKT) pathway is discovered to be a crucial regulator of the cell death process. AKT, as a proto-oncogene, has become a major focus of attention in the medical community due to its role in regulating a multiplicity of cellular functions counting metabolism, immunity, proliferation, survival, transcription, and protein synthesis. Here, we explored the connection between the PI3K/AKT pathway and cell death, aiming to enhance our comprehension of the mechanism underlying this process. Such knowledge may pave the way for the subsequent development of more effective disease treatments, such as finding suitable targets for drug intervention. | 2023 Sep | Journal of cellular physiology | No DOI | [
{
"LastName": "Xu",
"FirstName": "Jiawei",
"Affiliation": "Department of Medical Science Research Center, Peihua University, Xi'an, Shaanxi, China."
},
{
"LastName": "Li",
"FirstName": "Yu",
"Affiliation": "Department of Medical Science Research Center, Peihua University, Xi'an, Shaanxi, China."
},
{
"LastName": "Kang",
"FirstName": "Meili",
"Affiliation": "Department of Medical Science Research Center, Peihua University, Xi'an, Shaanxi, China."
},
{
"LastName": "Chang",
"FirstName": "Cuicui",
"Affiliation": "Department of Medical Science Research Center, Peihua University, Xi'an, Shaanxi, China."
},
{
"LastName": "Wei",
"FirstName": "Hong",
"Affiliation": "Department of Rehabilitation Teaching and Research, Xi'an Siyuan University, Xi'an, China."
},
{
"LastName": "Zhang",
"FirstName": "Chi",
"Affiliation": "Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China."
},
{
"LastName": "Chen",
"FirstName": "Yuhua",
"Affiliation": "Department of Neurosurgery, Life Science Research Laboratory, Bijie Traditional Chinese Medicine Hospital, Bijie, China."
}
] | No |
17989013 | With the best of intentions: Singapore volunteers and donors and the tsunami reconstruction. | Charities and humanitarian organisations in Singapore that were involved in post-Tsunami relief and reconstruction work are repeatedly queried by volunteers, donors, and journalists. The world has pledged and donated billions to Tsunami relief and reconstruction, and I have personally given money to Singapore charities. Why do I still read about needy people in temporary shelters? Where has the money gone? Another question reflects similar sentiments of puzzlement, even frustration: I am moved by the devastation and would like to help by volunteering my time and expertise. I have signed up to volunteer with several humanitarian organisations. I am highly qualified and could help people. Why am I still not sent overseas? These are good questions that deserve solid answers. This article discusses the latest thinking in relief circles as to which volunteers are best sent overseas and how donations can most responsibly be used for effective and sustainable reconstruction. The authors draw on Singapore's experience with providing relief in the aftermath of the Tsunami along with the Dr. Tan Tay Keong's observations of relief and rehabilitation efforts in the Tsunami-affected areas of Sri Lanka and Indonesia. The article finds that volunteering requires much more than just a giving heart. Also, donations may be used most effectively by thinking long term rather than just short term. Further, donations are best administered in a way coordinated with local relief plans and in consultation with local people. The article closes by considering lessons for volunteers, donors, and humanitarian relief agencies from the Tsunami's aftermath. | 2006 | Journal of social work in disability & rehabilitation | No DOI | [
{
"LastName": "Keong",
"FirstName": "Tan Tay",
"Affiliation": "Singapore International Foundation, Bishon Pl. Singapore."
},
{
"LastName": "Johnson Tan",
"FirstName": "Paige",
"Affiliation": ""
}
] | No |
35873114 | Preparation and Synergistic Anti-Tumor Effect of Iridium Oxide Nanocomposites under Microscope. | In order to solve the great difficulties in cancer prevention, diagnosis, and treatment, a preparation method of iridium oxide nanocomposites under the microscope was proposed in this paper. Through a retrospective analysis of an experiment, IrOx nanoparticles were prepared by direct hydrothermal hydrolysis and loaded with chemotherapy drug adriamycin to construct nanodrug-loaded complex IrOx@DOX. At the same time, IrOx, as a sound-sensitive agent, can produce ROS under US irradiation, amplify intracellular oxidative stress, accelerate tumor cell death, and finally achieve the effect of SDT chemotherapy synergistic therapy. The experimental results show that IrOx@DOX has the dual response of pH and US, and the inhibition rates are 27%, 57%, and 76%, respectively. At the same time, ultrasound not only can enhance the uptake of nanoparticles by cells but also can promote the release of DOX in cells, which provides a basis for subsequent SDT chemotherapy synergistic therapy. Conclusion. Iridium oxide nanocomposite DOX combined with SDT can obtain a good therapeutic effect, which has positive feedback on the efficacy of chemotherapy and the therapeutic effect of cancer surgery. | 2022 | International journal of analytical chemistry | No DOI | [
{
"LastName": "He",
"FirstName": "Xudong",
"Affiliation": "The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China."
},
{
"LastName": "Xiang",
"FirstName": "Feng",
"Affiliation": "The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China."
},
{
"LastName": "Xu",
"FirstName": "Zhangyi",
"Affiliation": "The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China."
}
] | Yes |
27020165 | Dental hard tissue ablation using mid-infrared tunable nanosecond pulsed Cr:CdSe laser. | Mid-infrared erbium: yttrium-aluminum-garnet (Er:YAG) and erbium, chromium: yttrium-scandium-gallium-garnet (Er,Cr:YSGG) lasers (2.94- and 2.78-μm, respectively) are utilized for effective dental hard tissue treatment because of their high absorption in water, hydroxide ion, or both. Recently, a mid-infrared tunable, nanosecond pulsed, all-solid-state chromium-doped: cadmium-selenide (Cr:CdSe) laser system was developed, which enables laser oscillation in the broad spectral range around 2.9 μm. The purpose of this study was to evaluate the ablation of dental hard tissue by the nanosecond pulsed Cr:CdSe laser at a wavelength range of 2.76-3.00 μm. Enamel, dentin, and cementum tissue were irradiated at a spot or line at a fluence of 0-11.20 J/cm[2] /pulse (energy output: 0-2.00 mJ/pulse) with a repetition rate of 10 Hz and beam diameter of ∼150 μm on the target (pulse width ∼250 ns). After irradiation, morphological changes, ablation threshold, depth, and efficiency, and thickness of the structurally and thermally affected layer of irradiated surfaces were analyzed using stereomicroscopy, scanning electron microscopy (SEM), and light microscopy of non-decalcified histological sections. The nanosecond pulsed irradiation without water spray effectively ablated dental hard tissue with no visible thermal damage such as carbonization. The SEM analysis revealed characteristic micro-irregularities without major melting and cracks in the lased tissue. The ablation threshold of dentin was the lowest at 2.76 μm and the highest at 3.00 μm. The histological analysis revealed minimal thermal and structural changes ∼20 μm wide on the irradiated dentin surfaces with no significant differences between wavelengths. The efficiency of dentin ablation gradually increased from 3.00 to 2.76 μm, at which point the highest ablation efficiency was observed. The nanosecond pulsed Cr:CdSe laser demonstrated an effective ablation ability of hard dental tissues, which was remarkably wavelength-dependent on dentin at the spectral range of 2.76-3.00 μm. These results demonstrate the potential feasibility of the use of pulsed Cr:CdSe laser as a novel laser system for dental treatment. Lasers Surg. Med. 48:965-977, 2016. © 2016 Wiley Periodicals, Inc. | 2016 Dec | Lasers in surgery and medicine | No DOI | [
{
"LastName": "Lin",
"FirstName": "Taichen",
"Affiliation": "Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan."
},
{
"LastName": "Aoki",
"FirstName": "Akira",
"Affiliation": "Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan."
},
{
"LastName": "Saito",
"FirstName": "Norihito",
"Affiliation": "Photonics Control Technology Team, Advanced Photonics Technology Development Group, RIKEN Center for Advanced Photonics, Riken, Wako, Saitama, Japan."
},
{
"LastName": "Yumoto",
"FirstName": "Masaki",
"Affiliation": "Photonics Control Technology Team, Advanced Photonics Technology Development Group, RIKEN Center for Advanced Photonics, Riken, Wako, Saitama, Japan."
},
{
"LastName": "Nakajima",
"FirstName": "Sadahiro",
"Affiliation": "Photonics Control Technology Team, Advanced Photonics Technology Development Group, RIKEN Center for Advanced Photonics, Riken, Wako, Saitama, Japan."
},
{
"LastName": "Nagasaka",
"FirstName": "Keigo",
"Affiliation": "Photonics Control Technology Team, Advanced Photonics Technology Development Group, RIKEN Center for Advanced Photonics, Riken, Wako, Saitama, Japan."
},
{
"LastName": "Ichinose",
"FirstName": "Shizuko",
"Affiliation": "Research Center for Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan."
},
{
"LastName": "Mizutani",
"FirstName": "Koji",
"Affiliation": "Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan."
},
{
"LastName": "Wada",
"FirstName": "Satoshi",
"Affiliation": "Photonics Control Technology Team, Advanced Photonics Technology Development Group, RIKEN Center for Advanced Photonics, Riken, Wako, Saitama, Japan."
},
{
"LastName": "Izumi",
"FirstName": "Yuichi",
"Affiliation": "Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan."
}
] | Yes |
36095661 | New insights into the transcriptional regulation of benzoxazinoid biosynthesis in wheat. | This article comments on: Batyrshina ZS, Shavit R, Yaakov B, Bocobza S, Tzin V. 2022. The transcription factor gene TaMYB31 regulates the benzoxazinoid biosynthetic pathway in wheat. Journal of Experimental Botany73, 5634-5649. Benzoxazinoids (BXDs) are abundant indole-derived specialized metabolites in several monocot crop species, such as wheat, maize, and rye. They function in plant immunity against herbivorous arthropods and fungal pathogens, but also as iron chelators, in metal tolerance, and as allelochemicals. Although BXD biosynthetic pathways have been studied extensively and are well described, information about the transcriptional regulation of BXD biosynthesis is scarce. In the current issue of JXB, Batyrshina et al. (2022) identified the transcription factor gene TaMYB31 in the tetraploid wheat Triticum turgidum and verified its function as a component of BXD metabolism in the hexaploid wheat Triticum aestivum, where it regulates constitutive and stress-inducible BXD biosynthesis. | 2022 Sep 12 | Journal of experimental botany | No DOI | [
{
"LastName": "Stahl",
"FirstName": "Elia",
"Affiliation": "Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland."
}
] | No |
39028714 | Occupational hazards and risks among the women in fisher communities in Cox's Bazar and Chattogram, Bangladesh. | Women in the fisher communities in coastal regions of Bangladesh are engaged in a wide range of fishery activities. However, there is limited evidence available on the occupational hazards and risks experienced by them. The study was conducted among fishing colonies in Cox's Bazar and Chattogram districts in Bangladesh. This was a cross-sectional study blending qualitative and quantitative approaches. The qualitative component comprised five focus group discussions to understand the occupational context, hazards, and risks faced by the fisherwomen, informing the questionnaire design for the subsequent survey. The quantitative survey involved a sample of 207 women from fisher communities, gathering socio-demographic information, occupational hazards, risks, and health and safety practices. The study found a high occurrence of occupational hazards, health risks and limited availability of preventive measures among the women in fisher communities. Occupational hazards include physical safety hazards such as slippery surfaces and fish cutting instruments, and physical hazards like prolonged sun exposure and noise. Chemical hazards like pesticides and saltwater, ergonomic hazards such as prolonged uncomfortable posture and heavy lifting, and biological hazards including inadequate sanitation facilities were prevalent. The study also identified the potential occupational risks, and the outcomes resulting from the hazards, including injuries (87.44%), musculoskeletal conditions (69.08%), skin diseases/conditions (56.52%), eye complaints (33.82%), severe respiratory distress (24.15%) and high incidence of self-reported communicable diseases. Most women (78.26%) did not use personal protective equipment, and the majority (93.72%) lacked a workplace first aid kit. The study revealed a high prevalence of occupational hazards and health risks, including injuries and diseases, among Bangladeshi women in fisher communities with insufficient safety measures. Collaboration among government, NGOs, development partners, fisheries stakeholders, and the community is imperative for targeted training, innovative procedures, ergonomic solutions, provision of protective equipment, and advocacy to enhance the well-being of these women. | 2024 | PloS one | No DOI | [
{
"LastName": "Halder",
"FirstName": "Charls Erik",
"Affiliation": "Public Health and Research Division, Bright Bangladesh Forum, Chattogram, Bangladesh."
},
{
"LastName": "Das",
"FirstName": "Partha Pratim",
"Affiliation": "Department of Public Health, State University of Bangladesh, Dhaka, Bangladesh."
},
{
"LastName": "Rahman",
"FirstName": "S M Tareq",
"Affiliation": "Department of Public Health, North South University, Dhaka, Bangladesh."
},
{
"LastName": "Bhoumick",
"FirstName": "Liton Chandra",
"Affiliation": "Department of Public Health, North South University, Dhaka, Bangladesh."
},
{
"LastName": "Tassdik",
"FirstName": "Hamim",
"Affiliation": "Department of Public Health, North South University, Dhaka, Bangladesh."
},
{
"LastName": "Hasan",
"FirstName": "Md Abeed",
"Affiliation": "Department of Public Health, North South University, Dhaka, Bangladesh."
},
{
"LastName": "Mithun",
"FirstName": "Sourav Nath",
"Affiliation": "Department of Public Health, North South University, Dhaka, Bangladesh."
}
] | No |
35958385 | Hotspot Mining in the Field of Library and Information Science under the Environment of Big Data. | Currently, with the implementation of big data strategies in countries all over the world, big data has achieved vigorous development in various fields. Big data research and application practices have also rapidly attracted the attention of the library and information field. Objective. The study explored the current state of research and research hotspots of big data in the library and information field and further discussed the future research trends. Methods. In the CNKI database, 16 CSSCI source journals in the discipline of library information and digital library were selected as data sources, and the relevant literature was retrieved with the theme of "big data." The collected literature was excluded and expanded according to the citation relationship. Then, with the help of Bicomb and SPSS, co-word analysis and cluster analysis would be carried out on these literature results. Results. According to the findings of the data analysis, the research hotspots on the topic mainly focus on five major research themes, namely, big data and smart library, big data and intelligence research, data mining and cloud computing, big data and information analysis, and library innovation and services. Limitations. At present, the research scope and coverage on this topic are wide, which leads to the research still staying at the macro level. Conclusions. Big data research will remain one of the hotspots in the future. However, the most study is still limited to the perspective of library and information and has not yet analyzed the research status, research hotspots, and development trends in this field from the perspective of big data knowledge structure. Moreover, machine learning, artificial intelligence, knowledge services, AR, and VR may be new directions for future attention and development. | 2022 | Journal of environmental and public health | No DOI | [
{
"LastName": "Jiang",
"FirstName": "Shujie",
"Affiliation": "Nanyang Normal University, Nanyang 473061, China."
}
] | Yes |
33470396 | Genomic and transcriptomic characterization of the human glioblastoma cell line AHOL1. | Cancer cell lines are widely used as in vitro models of tumorigenesis, facilitating fundamental discoveries in cancer biology and translational medicine. Currently, there are few options for glioblastoma (GBM) treatment and limited in vitro models with accurate genomic and transcriptomic characterization. Here, a detailed characterization of a new GBM cell line, namely AHOL1, was conducted in order to fully characterize its molecular composition based on its karyotype, copy number alteration (CNA), and transcriptome profiling, followed by the validation of key elements associated with GBM tumorigenesis. Large numbers of CNAs and differentially expressed genes (DEGs) were identified. CNAs were distributed throughout the genome, including gains at Xq11.1-q28, Xp22.33-p11.1, Xq21.1-q21.33, 4p15.1-p14, 8q23.2-q23.3 and losses at Yq11.21-q12, Yp11.31-p11.2, and 15q11.1-q11.2 positions. Nine druggable genes were identified, including HCRTR2, ETV1, PTPRD, PRKX, STS, RPS6KA6, ZFY, USP9Y, and KDM5D. By integrating DEGs and CNAs, we identified 57 overlapping genes enriched in fourteen pathways. Altered expression of several cancer-related candidates found in the DEGs-CNA dataset was confirmed by RT-qPCR. Taken together, this first comprehensive genomic and transcriptomic landscape of AHOL1 provides unique resources for further studies and identifies several druggable targets that may be useful for therapeutics and biologic and molecular investigation of GBM. | 2021 | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas | No DOI | [
{
"LastName": "Ferreira",
"FirstName": "W A S",
"Affiliation": "Laboratório de Cultura de Tecidos e Citogenética, SAMAM, Instituto Evandro Chagas, Ananindeua, PA, Brasil."
},
{
"LastName": "Amorim",
"FirstName": "C K N",
"Affiliation": "Laboratório de Cultura de Tecidos e Citogenética, SAMAM, Instituto Evandro Chagas, Ananindeua, PA, Brasil."
},
{
"LastName": "Burbano",
"FirstName": "R R",
"Affiliation": "Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brasil."
},
{
"LastName": "Villacis",
"FirstName": "R A R",
"Affiliation": "Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, Brasil."
},
{
"LastName": "Marchi",
"FirstName": "F A",
"Affiliation": "Centro Internacional de Pesquisa, A.C. Camargo Cancer Center, São Paulo, SP, Brasil."
},
{
"LastName": "Medina",
"FirstName": "T S",
"Affiliation": "Centro Internacional de Pesquisa, A.C. Camargo Cancer Center, São Paulo, SP, Brasil."
},
{
"LastName": "Lima",
"FirstName": "M M C de",
"Affiliation": "Instituto de Ciências Biológicas, Faculdade de Biomedicina, Universidade Federal do Pará, Belém, PA, Brasil."
},
{
"LastName": "Oliveira",
"FirstName": "E H C de",
"Affiliation": "Laboratório de Cultura de Tecidos e Citogenética, SAMAM, Instituto Evandro Chagas, Ananindeua, PA, Brasil."
}
] | No |
18249658 | Smooth side-match classified vector quantizer with variable block size. | Although the side-match vector quantizer (SMVQ) reduces the bit rate, the image coding quality by SMVQ generally degenerates as the gray level transition across the boundaries of the neighboring blocks is increasing or decreasing. This study presents a smooth side-match method to select a state codebook according to the smoothness of the gray levels between neighboring blocks. This method achieves a higher PSNR and better visual perception than SMVQ does for the same bit rate. Moreover, to design codebooks, a genetic clustering algorithm that automatically finds the appropriate number of clusters is proposed. The proposed smooth side-match classified vector quantizer (SSM-CVQ) is thus a combination of three techniques: the classified vector quantization, the variable block size segmentation and the smooth side-match method. Experimental results indicate that SSM-CVQ has a higher PSNR and a lower bit rate than other methods. Furthermore, the Lena image can be coded by SSM-CVQ with 0.172 bpp and 32.49 dB in PSNR. | 2001 | IEEE transactions on image processing : a publication of the IEEE Signal Processing Society | No DOI | [
{
"LastName": "Yang",
"FirstName": "S B",
"Affiliation": "Dept. of Appl. Math., Nat. Chung-Hsing Univ., Taichung."
},
{
"LastName": "Tseng",
"FirstName": "L Y",
"Affiliation": ""
}
] | No |
38950860 | Importance of conserved hydrophobic pocket region in yeast mitoribosomal mL44 protein for mitotranslation and transcript preference. | The mitochondrial ribosome (mitoribosome) is responsible for the synthesis of key oxidative phosphorylation subunits encoded by the mitochondrial genome. Defects in mitoribosomal function therefore can have serious consequences for the bioenergetic capacity of the cell. Mutation of the conserved mitoribosomal mL44 protein has been directly linked to childhood cardiomyopathy and progressive neurophysiology issues. To further explore the functional significance of the mL44 protein in supporting mitochondrial protein synthesis, we have performed a mutagenesis study of the yeast mL44 homolog, the MrpL3/mL44 protein. We specifically investigated the conserved hydrophobic pocket region of the MrpL3/mL44 protein, where the known disease-related residue in the human mL44 protein (L156R) is located. While our findings identify a number of residues in this region critical for MrpL3/mL44's ability to support the assembly of translationally active mitoribosomes, the introduction of the disease-related mutation into the equivalent position in the yeast protein (residue A186) was found to not have a major impact on function. The human and yeast mL44 proteins share many similarities in sequence and structure; however results presented here indicate that these two proteins have diverged somewhat in evolution. Finally, we observed that mutation of the MrpL3/mL44 does not impact the translation of all mitochondrial encoded proteins equally, suggesting the mitochondrial translation system may exhibit a transcript hierarchy and prioritization. | 2024 Aug | The Journal of biological chemistry | No DOI | [
{
"LastName": "Box",
"FirstName": "Jodie M",
"Affiliation": "Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA."
},
{
"LastName": "Higgins",
"FirstName": "Margo E",
"Affiliation": "Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA."
},
{
"LastName": "Stuart",
"FirstName": "Rosemary A",
"Affiliation": "Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA. Electronic address: [email protected]."
}
] | No |
34966522 | Study on the Impact of Online Courses for Pregnant and Lying-In Women on Maternal and Infant Health during the Epidemic. | The sudden outbreak of the new crown pneumonia has brought online learning from a supporting role to the center of the teaching stage in an instant. On the basis of the feasibility analysis and demand analysis of the microcourse learning system, this paper uses Sina cloud server to build the WeChat public platform learning online course and designs and implements the microcourse learning system function based on the microcourse public platform. We completed the recording, editing, publishing, and testing of microclass courses and provided services for teachers and pregnant women's microclass learning in order to achieve better learning results. A total of 151 people regularly participate in maternity school courses, accounting for 30.4%. There are 190 people who have never attended the maternity school course, accounting for 38.2%. There are 156 people who occasionally participate in maternity school courses, accounting for 31.4%. The top five sources of health information during pregnancy are books, maternity schools, experience of elders, the Internet, and television. The results of one-way analysis of variance showed that pregnant women of different ages had statistically different scores in the dimensions of knowledge and ideas (P < 0.05). There are statistical differences in the scores of pregnant women with different economic incomes in this dimension (P < 0.05). The women with economic income ≥5000 yuan/month have the highest scores, and those with economic income ≥5000 yuan/month have the lowest scores. The scores of pregnant women who participated in the maternity school were significantly higher than those who did not participate in the maternity school (P < 0.05). There are statistical differences in the scores of maternal and child health basic skills among pregnant women of different age groups (P < 0.05). The women aged ≥35 years old have the highest scores, and those aged 20-24 years old have the lowest scores. The differences in the scores of pregnant women with different economic incomes in this dimension are statistically significant (P＜0.05). The women with economic income ≥5000 yuan/month have the highest score, and those with economic income<2000 yuan/month have the lowest score. Participation in maternity schools has an impact on the scores of this dimension. Pregnant women who regularly participate in maternity schools have the highest average scores, and those who do not participate in maternity schools have the lowest average scores. | 2021 | Journal of healthcare engineering | No DOI | [
{
"LastName": "Shi",
"FirstName": "Liangfang",
"Affiliation": "Department of Obstetrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou 310006, China."
},
{
"LastName": "Yuan",
"FirstName": "Ling",
"Affiliation": "Department of Obstetrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou 310006, China."
},
{
"LastName": "Zhou",
"FirstName": "Lin",
"Affiliation": "Department of Obstetrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou 310006, China."
},
{
"LastName": "Zhang",
"FirstName": "Shuixian",
"Affiliation": "Department of Obstetrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou 310006, China."
},
{
"LastName": "Lei",
"FirstName": "Xia",
"Affiliation": "Department of Obstetrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou 310006, China."
}
] | Yes |
32434191 | Interleukin-1β as a Predictor of Glucocorticoid Response in Ulcerative Colitis. | Currently, there are no established biomarkers to differentiate between glucocorticoid (GC)-resistant and GC-sensitive ulcerative colitis (UC); however, interleukin (IL)-1β could be one such candidate biomarker. The aim of this study was to investigate whether mucosally expressed IL-1β could predict the response to GC in patients with UC. A total of 27 mucosal tissue samples from 10 patients with GC-resistant UC (GC-resistant group), 9 patients with GC-sensitive UC (GC-sensitive group), and 8 control patients (control group) were analyzed by qRT-PCR for the expression of IL-1β, GC receptor α (GRα), GRβ, and other inflammatory mediators. Rachmilewitz endoscopic index (REI) between the GC-resistant and GC-sensitive groups was matched to avoid any potential influence of inflammation. The REI did not significantly differ between the GC-resistant and GC-sensitive groups. Mucosally expressed IL-1β levels in the GC-resistant group were significantly higher than those in the GC-sensitive group. However, there were no significant differences in the expression levels of GRα, GRβ, and other inflammatory mediators between the 2 groups. We could distinguish between the GC-resistant and GC-sensitive groups with a sensitivity of 90.0% and specificity of 77.8% based on mucosally expressed IL-1β. Mucosally expressed IL-1β can be used as a predictor of GC response in patients with UC. | 2021 | Digestion | No DOI | [
{
"LastName": "Okuno",
"FirstName": "Hiroaki",
"Affiliation": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan."
},
{
"LastName": "Ogino",
"FirstName": "Haruei",
"Affiliation": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, [email protected]."
},
{
"LastName": "Ihara",
"FirstName": "Eikichi",
"Affiliation": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan."
},
{
"LastName": "Nishioka",
"FirstName": "Kei",
"Affiliation": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan."
},
{
"LastName": "Iboshi",
"FirstName": "Yoichiro",
"Affiliation": "Department of Gastroenterology, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan."
},
{
"LastName": "Chinen",
"FirstName": "Takatoshi",
"Affiliation": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan."
},
{
"LastName": "Ochiai",
"FirstName": "Toshiaki",
"Affiliation": "Department of Internal Medicine, Saiseikai Fukuoka General Hospital, Fukuoka, Japan."
},
{
"LastName": "Akiho",
"FirstName": "Hirotada",
"Affiliation": "Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka, Japan."
},
{
"LastName": "Nakamura",
"FirstName": "Kazuhiko",
"Affiliation": "Department of Gastroenterology, Harasanshin Hospital, Fukuoka, Japan."
},
{
"LastName": "Gotoda",
"FirstName": "Takuji",
"Affiliation": "Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan."
},
{
"LastName": "Ogawa",
"FirstName": "Yoshihiro",
"Affiliation": "Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan."
}
] | No |
31093558 | Using ordinal outcomes to construct and select biomarker combinations for single-level prediction. | Biomarker studies may involve an ordinal outcome, such as no, mild, or severe disease. There is often interest in predicting one particular level of the outcome due to its clinical significance. A simple approach to constructing biomarker combinations in this context involves dichotomizing the outcome and using a binary logistic regression model. We assessed whether more sophisticated methods offer advantages over this simple approach. It is often necessary to select among several candidate biomarker combinations. One strategy involves selecting a combination based on its ability to predict the outcome level of interest. We propose an algorithm that leverages the ordinal outcome to inform combination selection. We apply this algorithm to data from a study of acute kidney injury after cardiac surgery, where kidney injury may be absent, mild, or severe. Using more sophisticated modeling approaches to construct combinations provided gains over the simple binary logistic regression approach in specific settings. In the examples considered, the proposed algorithm for combination selection tended to reduce the impact of bias due to selection and to provide combinations with improved performance. Methods that utilize the ordinal nature of the outcome in the construction and/or selection of biomarker combinations have the potential to yield better combinations. | 2018 | Diagnostic and prognostic research | No DOI | [
{
"LastName": "Meisner",
"FirstName": "Allison",
"Affiliation": "1Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA."
},
{
"LastName": "Parikh",
"FirstName": "Chirag R",
"Affiliation": "2Program of Applied Translational Research, Department of Medicine, Yale School of Medicine, New Haven, CT USA."
},
{
"LastName": "Kerr",
"FirstName": "Kathleen F",
"Affiliation": "4Department of Biostatistics, University of Washington, Seattle, WA USA."
}
] | No |
38836799 | 2D Hybrid Perovskite Sensors for Environmental and Healthcare Monitoring. | Layered perovskites, a novel class of two-dimensional (2D) layered materials, exhibit versatile photophysical properties of great interest in photovoltaics and optoelectronics. However, their instability to environmental factors, particularly water, has limited their utility. In this study, we introduce an innovative solution to the problem by leveraging the unique properties of natural beeswax as a protective coating of 2D-fluorinated phenylethylammonium lead iodide perovskite. These photodetectors show outstanding figures of merit, such as a responsivity of >2200 A/W and a detectivity of 2.4 × 10[18] Jones. The hydrophobic nature of beeswax endows the 2D perovskite sensors with an unprecedented resilience to prolonged immersion in contaminated water, and it increases the lifespan of devices to a period longer than one year. At the same time, the biocompatibility of the beeswax and its self-cleaning properties make it possible to use the very same turbidity sensors for healthcare in photoplethysmography and monitor the human heartbeat with clear systolic and diastolic signatures. Beeswax-enabled multipurpose optoelectronics paves the way to sustainable electronics by ultimately reducing the need for multiple components. | 2024 Jun 19 | ACS applied materials & interfaces | No DOI | [
{
"LastName": "Riisnaes",
"FirstName": "Karl Jonas",
"Affiliation": "Centre for Graphene Science, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QL, U.K."
},
{
"LastName": "Alshehri",
"FirstName": "Mohammed",
"Affiliation": "Centre for Graphene Science, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QL, U.K."
},
{
"LastName": "Leontis",
"FirstName": "Ioannis",
"Affiliation": "Centre for Graphene Science, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QL, U.K."
},
{
"LastName": "Mastria",
"FirstName": "Rosanna",
"Affiliation": "Centre for Graphene Science, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QL, U.K."
},
{
"LastName": "Lam",
"FirstName": "Hoi Tung",
"Affiliation": "Centre for Graphene Science, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QL, U.K."
},
{
"LastName": "De Marco",
"FirstName": "Luisa",
"Affiliation": "Institute of Nanotechnology, Via Monteroni, Lecce 73100, Italy."
},
{
"LastName": "Coriolano",
"FirstName": "Annalisa",
"Affiliation": "Institute of Nanotechnology, Via Monteroni, Lecce 73100, Italy."
},
{
"LastName": "Craciun",
"FirstName": "Monica Felicia",
"Affiliation": "Centre for Graphene Science, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QL, U.K."
},
{
"LastName": "Russo",
"FirstName": "Saverio",
"Affiliation": "Centre for Graphene Science, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QL, U.K."
}
] | No |
29495973 | MicroRNA-623 Targets Cyclin D1 to Inhibit Cell Proliferation and Enhance the Chemosensitivity of Cells to 5-Fluorouracil in Gastric Cancer. | The dysregulation of microRNAs (miRNAs) plays an important function in the onset and progression of gastric cancer (GC). In addition, aberrantly expressed miRNAs affect the chemosensitivity of GC cells to chemotherapeutic drugs. Hence, miRNA-based targeted therapy might be applied to treat patients with GC exhibiting chemotherapeutic resistance. In this study, miRNA-623 (miR-623) expression was downregulated in GC tissues and cell lines. Functional analysis showed that the restored miR-623 expression could inhibit the proliferation of GC cells and enhance their chemosensitivity to 5-FU via the cell apoptosis pathway. Cyclin D1 (CCND1) was identified as a direct target gene of miR-623 in GC. The overexpressed CCND1 in GC tissues was negatively correlated with miR-623 level. The recovered CCND1 expression counteracted the effects of miR-623 on GC cell proliferation, chemosensitivity, and 5-FU-induced apoptosis. Thus, our results suggest that miR-623 might function as a tumor suppressor in GC and could be a promising therapeutic target for patients with GC, especially those with chemotherapeutic resistance. | 2018 Dec 27 | Oncology research | No DOI | [
{
"LastName": "Jiang",
"FirstName": "Lihua",
"Affiliation": "Department of Oncology, Linyi Third People's Hospital, Shandong, P.R. China."
},
{
"LastName": "Yang",
"FirstName": "Wenchuan",
"Affiliation": "Department of Oncology, Linyi Third People's Hospital, Shandong, P.R. China."
},
{
"LastName": "Bian",
"FirstName": "Weishi",
"Affiliation": "Department of Cardiology, Linyi Third People's Hospital, Shandong, P.R. China."
},
{
"LastName": "Yang",
"FirstName": "Hailin",
"Affiliation": "Department of Oncology, Linyi Third People's Hospital, Shandong, P.R. China."
},
{
"LastName": "Wu",
"FirstName": "Xia",
"Affiliation": "Department of Oncology, Linyi Third People's Hospital, Shandong, P.R. China."
},
{
"LastName": "Li",
"FirstName": "Yuhua",
"Affiliation": "Department of Oncology, Linyi Third People's Hospital, Shandong, P.R. China."
},
{
"LastName": "Feng",
"FirstName": "Wen",
"Affiliation": "Department of Oncology, Linyi Third People's Hospital, Shandong, P.R. China."
},
{
"LastName": "Liu",
"FirstName": "Xuejian",
"Affiliation": "Department of Oncology, Linyi Third People's Hospital, Shandong, P.R. China."
}
] | No |
34858493 | Construction of Financial Management Early Warning Model Based on Improved Ant Colony Neural Network. | With the advent of the era of economic globalization, the world capital market is also facing financial risks. It is necessary to have a corresponding financial management early warning model to reduce economic losses. This paper uses the combination of ant colony algorithm and neural network algorithm to build a neural network improved by ant colony algorithm model. By setting relevant assumptions, the financial statements and annual report texts are predicted and analyzed and compared with the original static data forecasting model. Compared with traditional methods, the time series sequencing analysis used in this paper makes the result prediction more accurate. This allows one year's data to be used to predict the data for the next two years. This research can provide a corresponding reference for the optimization of financial management early warning system. | 2021 | Computational intelligence and neuroscience | No DOI | [
{
"LastName": "Wang",
"FirstName": "Meiluan",
"Affiliation": "Department of Accounting, Zhejiang Gongshang University, Hangzhou, Zhejiang 310018, China."
}
] | Yes |
37779220 | Plasmodium vivax Prevalence in Semiarid Region of Northern Kenya, 2019. | In urban and rural areas of Turkana County, Kenya, we found that 2% of household members of patients with Plasmodium falciparum infections were infected with P. vivax. Enhanced surveillance of P. vivax and increased clinical resources are needed to inform control measures and identify and manage P. vivax infections. | 2023 Nov | Emerging infectious diseases | No DOI | [
{
"LastName": "O'Meara",
"FirstName": "Wendy Prudhomme",
"Affiliation": ""
},
{
"LastName": "Maraga",
"FirstName": "Linda",
"Affiliation": ""
},
{
"LastName": "Meredith",
"FirstName": "Hannah",
"Affiliation": ""
},
{
"LastName": "Esimit",
"FirstName": "Daniel",
"Affiliation": ""
},
{
"LastName": "Lokoel",
"FirstName": "Gilchrist",
"Affiliation": ""
},
{
"LastName": "Chepkwony",
"FirstName": "Tabitha",
"Affiliation": ""
},
{
"LastName": "Kipkoech",
"FirstName": "Joseph",
"Affiliation": ""
},
{
"LastName": "Ambani",
"FirstName": "George",
"Affiliation": ""
},
{
"LastName": "Menya",
"FirstName": "Diana",
"Affiliation": ""
},
{
"LastName": "Freedman",
"FirstName": "Elizabeth",
"Affiliation": ""
},
{
"LastName": "Taylor",
"FirstName": "Steve",
"Affiliation": ""
},
{
"LastName": "Obala",
"FirstName": "Andrew",
"Affiliation": ""
}
] | No |
33495783 | Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction. | Despite early reperfusion, patients with ST segment elevation myocardial infarction (STEMI) may present large myocardial necrosis and significant impairment of ventricular function. The present study aimed to evaluate the role of subtypes of B lymphocytes and related cytokines in the infarcted mass and left ventricular ejection fraction obtained by cardiac magnetic resonance imaging performed after 30 days of STEMI. This prospective study included 120 subjects with STEMI submitted to pharmacoinvasive strategy. Blood samples were collected in subjects in the first (D1) and 30th (D30) days post STEMI. The amount of CD11b+ B1 lymphocytes (cells/ml) at D1 were related to the infarcted mass (rho = 0.43; P=0.033), measured by cardiac MRI at D30. These B1 cells were associated with CD4+ T lymphocytes at D1 and D30, while B2 classic lymphocytes at day 30 were related to left ventricular ejection fraction (LVEF). Higher titers of circulating IL-4 and IL-10 were observed at D30 versus D1 (P=0.013 and P<0.001, respectively). Titers of IL-6 at D1 were associated with infarcted mass (rho = 0.41, P<0.001) and inversely related to LVEF (rho = -0.38, P<0.001). After multiple linear regression analysis, high-sensitivity troponin T and IL-6 collected at day 1 were independent predictors of infarcted mass and, at day 30, only HDL-C. Regarding LVEF, high-sensitivity troponin T and high-sensitivity C-reactive protein were independent predictors at day 1, and B2 classic lymphocytes, at day 30. In subjects with STEMI, despite early reperfusion, the amount of infarcted mass and ventricular performance were related to inflammatory responses triggered by circulating B lymphocytes. | 2021 Feb 26 | Bioscience reports | No DOI | [
{
"LastName": "Casarotti",
"FirstName": "Ana C A",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Teixeira",
"FirstName": "Daniela",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Longo-Maugeri",
"FirstName": "Ieda M",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Ishimura",
"FirstName": "Mayari E",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Coste",
"FirstName": "Maria E R",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Bianco",
"FirstName": "Henrique T",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Moreira",
"FirstName": "Flavio T",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Bacchin",
"FirstName": "Amanda F",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Izar",
"FirstName": "Maria C",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Gonçalves",
"FirstName": "Iran",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Caixeta",
"FirstName": "Adriano",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Szarf",
"FirstName": "Gilberto",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Pinto",
"FirstName": "Ibraim M",
"Affiliation": "Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil."
},
{
"LastName": "Fonseca",
"FirstName": "Francisco A",
"Affiliation": "Universidade Federal de São Paulo, São Paulo, Brazil."
}
] | No |
16908528 | Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progression. | The retinoblastoma (RB) and p16ink4a tumor suppressors are believed to function in a linear pathway that is functionally inactivated in a large fraction of human cancers. Recent studies have shown that RB plays a critical role in regulating S phase as a means for suppressing aberrant proliferation and controlling genome stability. Here, we demonstrate a novel role for p16ink4a in replication control that is distinct from that of RB. Specifically, p16ink4a disrupts prereplication complex assembly by inhibiting mini-chromosome maintenance (MCM) protein loading in G1, while RB was found to disrupt replication in S phase through attenuation of PCNA function. This influence of p16ink4a on the prereplication complex was dependent on the presence of RB and the downregulation of cyclin-dependent kinase (CDK) activity. Strikingly, the inhibition of CDK2 activity was not sufficient to prevent the loading of MCM proteins onto chromatin, which supports a model wherein the composite action of multiple G1 CDK complexes regulates prereplication complex assembly. Additionally, p16ink4a attenuated the levels of the assembly factors Cdt1 and Cdc6. The enforced expression of these two licensing factors was sufficient to restore the assembly of the prereplication complex yet failed to promote S-phase progression due to the continued absence of PCNA function. Combined, these data reveal that RB and p16ink4a function through distinct pathways to inhibit the replication machinery and provide evidence that stepwise regulation of CDK activity interfaces with the replication machinery at two discrete execution points. | 2006 Oct | Molecular and cellular biology | No DOI | [
{
"LastName": "Braden",
"FirstName": "Wesley A",
"Affiliation": "Department of Cell Biology, Vontz Center for Molecular Studies, 3125 Eden Avenue, Cincinnati, OH 45267-0521, USA."
},
{
"LastName": "Lenihan",
"FirstName": "Jon M",
"Affiliation": ""
},
{
"LastName": "Lan",
"FirstName": "Zhengdao",
"Affiliation": ""
},
{
"LastName": "Luce",
"FirstName": "K Scott",
"Affiliation": ""
},
{
"LastName": "Zagorski",
"FirstName": "William",
"Affiliation": ""
},
{
"LastName": "Bosco",
"FirstName": "Emily",
"Affiliation": ""
},
{
"LastName": "Reed",
"FirstName": "Michael F",
"Affiliation": ""
},
{
"LastName": "Cook",
"FirstName": "Jeanette G",
"Affiliation": ""
},
{
"LastName": "Knudsen",
"FirstName": "Erik S",
"Affiliation": ""
}
] | Yes |
34531689 | Performance of Xpert MTB/RIF Ultra for the Diagnosis of Pulmonary Tuberculosis Using Bronchoalveolar Lavage Samples in People Living with HIV/AIDS (PLWHA) in China: A Prospective Study. | Sputum is commonly used for the diagnostic testing of pulmonary tuberculosis (PTB), but people living with HIV/AIDS (PLWHA) usually have little sputum. Moreover, the automated molecular test, Xpert MTB/RIF assay (Xpert), has a low sensitivity in PLWHA. We aimed to estimate the performance of Xpert Ultra on the detection of Mycobacterium tuberculosis (MTB) using bronchoalveolar lavage (BAL). From February 5, 2018 to March 30, 2019, a total of 99 PLWHA with suspected PTB at the Third People's Hospital of Shenzhen, China, were recruited. The information on demographics and medical history, blood MTB antigen-specific interferon gamma enzyme-linked immunospot assay (T-SPOT.TB), T lymphocyte subsets, and plasma HIV RNA load were collected. Computed tomography (CT) and flexible bronchoscopy were performed, and BAL and blood samples were collected. Testing of acid-fast bacilli (AFB), tuberculosis real-time fluorescence quantitative PCR (TBDNA), Ultra, Xpert, and MTB culture were conducted. Compared to BAL MTB culture for tuberculosis diagnosis, Ultra, Xpert, T-SPOT.TB, TBDNA and AFB smear had the sensitivity of 0.96 (24/25), 0.80 (20/25), 0.84 (21/25), 0.44 (11/25), and 0.12 (3/25), respectively; and the specificity of 0.92 (68/74), 0.96 (71/74), 0.93 (69/74), 0.96 (71/74), and 0.99 (73/74), respectively. Our study found that the sensitivity of Ultra was higher than that of culture and Xpert (AUC 0.92, 0.86 and 0.84, respectively). The results also indicated that PLWHA with CD4 <200 cells/mm[3] had reduced both sensitivity (from 1.00 and 0.86 to 0.94 and 0.78, respectively) and specificity (from 0.96 and 1.00 to 0.90 and 0.41, respectively) of Ultra and Xpert for the diagnosis of PTB. Our data supported an increased sensitivity of Ultra compared to that of Xpert on BAL samples of PLWHA, regardless of the CD4 counts and reference diagnosis standards. | 2021 | HIV/AIDS (Auckland, N.Z.) | No DOI | [
{
"LastName": "Zhang",
"FirstName": "Peize",
"Affiliation": "Department of Lung Disease, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Liu",
"FirstName": "HouMing",
"Affiliation": "Department of Clinical Laboratory, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Hui",
"Affiliation": "Department of Infectious Disease No.1, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Wu",
"FirstName": "Yanbo",
"Affiliation": "Department of Infectious Disease, Shenzhen Longhua New District Central Hospital, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Sun",
"FirstName": "Liqin",
"Affiliation": "Department of Infectious Disease No.1, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Rao",
"FirstName": "Man",
"Affiliation": "Department of Infectious Disease No.1, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Jia",
"FirstName": "Xinyun",
"Affiliation": "Department of Infectious Disease No.1, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Song",
"FirstName": "Ying",
"Affiliation": "Department of Infectious Disease No.1, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Deng",
"FirstName": "Guofang",
"Affiliation": "Department of Lung Disease, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Li",
"FirstName": "Tianpin",
"Affiliation": "Department of Clinical Laboratory, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Ye",
"FirstName": "Feidi",
"Affiliation": "Department of Clinical Laboratory, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Zhou",
"FirstName": "Yang",
"Affiliation": "Department of Infectious Disease No.1, The Third People's Hospital of Shenzhen, Shenzhen City, Guangdong Province, People's Republic of China."
},
{
"LastName": "Liao",
"FirstName": "Yi",
"Affiliation": "Department of Primary Health Promotion, Shenzhen Center for Disease Control and Prevention, Shenzhen City, Guangdong Province, People's Republic of China."
}
] | No |
36045964 | Inspecting Decorative Ceramic Defects by Fusing Convolutional Neural Network and Image Recognition. | The intelligent inspection of ceramic decorative defects is one of the hot research at present. This work aims to improve the defect inspection automation of finished decorative ceramic workpieces. First, it introduces the multi-target detection algorithm and compares the performance of different network models on the public data set. Second, the initial images are collected on the spot. The initial pictures are easy to produce noise in actual deployment, affecting the image quality. Therefore, image preprocessing is performed for the initial images, and a median filtering method is used to calculate the denoising. Finally, the original You Only Look Once version 3 network model is realized. Based on this, the decorative ceramic-oriented Automated Surface Defect Inspection model is proposed. Then, decorative ceramic defect images are inputted for model training. The experimental conclusions are deeply studied and analyzed. The results show that the proposed decorative ceramic-oriented Automated Surface Defect Inspection model based on Deep Learning technology has good feature extraction and inspection ability. The detection accuracy is 94.90% on the test set, and the detection speed reaches 25 frames per second. Compared with the traditional manual inspection method, the proposed model greatly improves the inspection effect and can meet the on-site inspection requirements of surface defects of decorative ceramics under complex backgrounds. It is of great significance to improve the quality inspection efficiency and economic benefits of China's decorative ceramics industry. | 2022 | Computational intelligence and neuroscience | No DOI | [
{
"LastName": "Jin",
"FirstName": "Kaiyan",
"Affiliation": "Jingdezhen Ceramic University, Jingdezhen 333403, Jiangxi, China."
},
{
"LastName": "Wang",
"FirstName": "Chunbin",
"Affiliation": "Huzhou University, Huzhou 313000, Zhejiang, China."
}
] | Yes |
37192931 | KIF4A Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Proliferation in vitro and in vivo [Retraction]. | [This retracts the article DOI: 10.2147/OTT.S240734.]. | 2023 | OncoTargets and therapy | No DOI | [] | No |
26793146 | Selecting Presuppositions in Conditional Clauses. Results from a Psycholinguistic Experiment. | In this paper, we propose an experiment concerning presupposition selection in conditional sentences containing a presupposition trigger in the consequent. Many theories claim that sentences like if p, q q'-where q is the presupposition of the assertive component q'-have unconditional presuppositions, namely, they simply project q. Other theories suggest that these kinds of conditional sentences project conditional presuppositions of the form if p, q. Data collected suggest two results: (i) in accordance with other experiments (by Romoli), dependence between the presupposition q and the antecedent p favors the selection of a conditional presupposition if p, q. (ii) presupposition selection in conditional sentences with a trigger in the consequent is affected by speakers' cognitive load: if speakers are highly cognitive loaded, then they are less disposed to select a conditional presupposition. We conclude by arguing that cognitive load represents a key factor for the analysis of linguistic and philosophical theories of context. | 2015 | Frontiers in psychology | No DOI | [
{
"LastName": "Domaneschi",
"FirstName": "Filippo",
"Affiliation": "University of Genoa Genoa, Italy."
},
{
"LastName": "Carrea",
"FirstName": "Elena",
"Affiliation": "University of Genoa Genoa, Italy."
},
{
"LastName": "Penco",
"FirstName": "Carlo",
"Affiliation": "University of Genoa Genoa, Italy."
},
{
"LastName": "Greco",
"FirstName": "Alberto",
"Affiliation": "University of Genoa Genoa, Italy."
}
] | No |
38862056 | Magnetic bio-composite based on zirconium and chitosan modified activated carbon from peanut husk with enhanced antibacterial and adsorptive potential for alizarin red and congo red in wastewater. | Creating new adsorbents is crucial for removing contaminants from water due to increased industrialization, which has worsened water pollution in recent years. In this study, a magnetic biocomposite, Zirconium (Zr)-doped chitosan (CS)-coated iron oxide nanoparticles (Fe3O4-NPs)-peanut husk (PH)-based activated carbon (AC) (Zr-CS/Fe3O4-NPs@PH-AC), was synthesized for efficient removal of alizarin red (AR) and congo red (CR) dyes, alongside antibacterial applications. Characterization via scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) analysis revealed micropores and mesopores development due to chemical activation of PH biomaterial and Fe3O4-NPs addition. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) identified functional groups and structural properties. Vibrating sample magnetometry (VSM) analyzed magnetic properties. Optimal conditions for AR/CR removal were determined, including Zr-CS/Fe3O4-NPs@PH-AC dose, dye dose, contact time, and temperature, achieving maximum removal percentages. Experimentally determined maximum adsorption capacities for AR and CR were 374.3 and 154.1 mg·g[-1], respectively. Cytotoxicity studies affirmed the eco-friendly and non-toxic nature of the adsorbent by exhibiting the reduction in the cell viability from 100 % to 88.68 % from the 0 to 200 μg·L[-1] respectively. Additionally, the biocomposite exhibited significant antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) due to magnetic NPs. The material in this study shows extreme compatibility for numerous applications. | 2024 Jul | International journal of biological macromolecules | No DOI | [
{
"LastName": "Rashda",
"FirstName": "College of Chemistry, Zhengzhou University, No 100 of Kexue Road, Zhengzhou 450001, PR China.",
"Affiliation": ""
},
{
"LastName": "Liu",
"FirstName": "Yang",
"Affiliation": "College of Chemistry, Zhengzhou University, No 100 of Kexue Road, Zhengzhou 450001, PR China."
},
{
"LastName": "Gao",
"FirstName": "Huihui",
"Affiliation": "College of Chemistry, Zhengzhou University, No 100 of Kexue Road, Zhengzhou 450001, PR China."
},
{
"LastName": "Li",
"FirstName": "Zhaohui",
"Affiliation": "College of Chemistry, Zhengzhou University, No 100 of Kexue Road, Zhengzhou 450001, PR China. Electronic address: [email protected]."
},
{
"LastName": "Han",
"FirstName": "Runping",
"Affiliation": "College of Chemistry, Zhengzhou University, No 100 of Kexue Road, Zhengzhou 450001, PR China. Electronic address: [email protected]."
}
] | No |
37715046 | Effect of early oral carbohydrate intake after elective Cesarean delivery on maternal body temperature and satisfaction: a randomized controlled trial. | Although the Enhanced Recovery After Cesarean Delivery (ERAC) consensus statement provides recommendations for early postoperative drinking and eating, evidence from high-quality clinical research directly addressing parturients is sparse. Our objective was to assess if early oral carbohydrate intake after elective Cesarean delivery improves maternal recovery. In this randomized controlled trial, we enrolled parturients undergoing elective Cesarean delivery under spinal anesthesia with tympanic membrane temperatures ≤ 36.5 °C immediately upon arrival at the postanesthesia care unit. Parturients were randomized to either 100 mL of oral complex carbohydrate intake (group CC) or 10 mL of water (group C). The primary outcome was maternal tympanic membrane temperature. Other outcomes included maternal thermal comfort score, degree of shivering, satisfaction, degree of thirst and hunger, and gastric emptying assessed by ultrasonography. We included 90 participants in the final analysis. The mean (standard deviation [SD]) maternal body temperature at 120 min after ingestion was 36.7 (0.3) °C in group CC and 36.6 (0.3) °C in group C (difference in means, 0.14 °C; 95% confidence interval, 0.02 to 0.26; P = 0.02). Furthermore, using repeated measure models, the linear trends of temperature changes over time between groups CC and C were significantly different (P = 0.04). The thermal comfort scores at 120 min after ingestion were higher in group CC than in group C (P = 0.02), and the linear trends of shivering score changes over time between groups CC and C also were different (P = 0.003). The mean (SD) visual analogue scale scores for maternal satisfaction were 84 (13) mm in group CC and 47 (20) mm in group C (P < 0.001). Nevertheless, at 90 and 120 min after ingestion, there were no differences between the two groups in the number of participants with a gastric antrum cross-sectional area > 10.3 cm[2]. Early oral carbohydrate intake after Cesarean delivery helped to restore maternal body temperature postoperatively and improve maternal satisfaction. Nevertheless, the clinical importance of these finding is unclear, given that most of the differences were small. In addition, there was no delay in maternal gastric emptying after consumption of a complex carbohydrate beverage in the early post-Cesarean period. www.chictr.org.cn (ChiCTR2000031085); first submitted 13 November 2022. | 2023 Oct | Canadian journal of anaesthesia = Journal canadien d'anesthesie | No DOI | [
{
"LastName": "Liu",
"FirstName": "Jingjing",
"Affiliation": "Department of Anaesthesiology, Obstetrics and Gynaecology Hospital, Fudan University, 128 Shenyang Rd., Yangpu District, Shanghai, 200090, China."
},
{
"LastName": "Dong",
"FirstName": "Sulin",
"Affiliation": "Department of Anaesthesiology, Obstetrics and Gynaecology Hospital, Fudan University, 128 Shenyang Rd., Yangpu District, Shanghai, 200090, China."
},
{
"LastName": "Li",
"FirstName": "Weiyi",
"Affiliation": "Department of Anaesthesiology, Obstetrics and Gynaecology Hospital, Fudan University, 128 Shenyang Rd., Yangpu District, Shanghai, 200090, China."
},
{
"LastName": "Yu",
"FirstName": "Xinhua",
"Affiliation": "Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA."
},
{
"LastName": "Huang",
"FirstName": "Shaoqiang",
"Affiliation": "Department of Anaesthesiology, Obstetrics and Gynaecology Hospital, Fudan University, 128 Shenyang Rd., Yangpu District, Shanghai, 200090, China. [email protected]."
}
] | No |
16578867 | Winners don't take all: Characterizing the competition for links on the web. | As a whole, the World Wide Web displays a striking "rich get richer" behavior, with a relatively small number of sites receiving a disproportionately large share of hyperlink references and traffic. However, hidden in this skewed global distribution, we discover a qualitatively different and considerably less biased link distribution among subcategories of pages-for example, among all university homepages or all newspaper homepages. Although the connectivity distribution over the entire web is close to a pure power law, we find that the distribution within specific categories is typically unimodal on a log scale, with the location of the mode, and thus the extent of the rich get richer phenomenon, varying across different categories. Similar distributions occur in many other naturally occurring networks, including research paper citations, movie actor collaborations, and United States power grid connections. A simple generative model, incorporating a mixture of preferential and uniform attachment, quantifies the degree to which the rich nodes grow richer, and how new (and poorly connected) nodes can compete. The model accurately accounts for the true connectivity distributions of category-specific web pages, the web as a whole, and other social networks. | 2002 Apr 16 | Proceedings of the National Academy of Sciences of the United States of America | No DOI | [
{
"LastName": "Pennock",
"FirstName": "David M",
"Affiliation": "NEC Research Institute, 4 Independence Way, Princeton, NJ 08540; and School of Information Sciences and Technology and Department of Computer Science and Engineering, Pennsylvania State University, University Park, PA 16801."
},
{
"LastName": "Flake",
"FirstName": "Gary W",
"Affiliation": ""
},
{
"LastName": "Lawrence",
"FirstName": "Steve",
"Affiliation": ""
},
{
"LastName": "Glover",
"FirstName": "Eric J",
"Affiliation": ""
},
{
"LastName": "Giles",
"FirstName": "C Lee",
"Affiliation": ""
}
] | No |
35851415 | Extracellular matrix derived from Wharton's Jelly-derived mesenchymal stem cells promotes angiogenesis via integrin αVβ3/c-Myc/P300/VEGF. | Angiogenesis is required in many physiological conditions, including bone regeneration, wound healing, and tissue regeneration. Mesenchymal stem cells-derived extracellular matrix (MSCs-ECM) could guide intricate cellular and tissue processes such as homeostasis, healing and regeneration. The purpose of this study is to explore the effect and mechanism of ECM derived from decellularized Wharton's Jelly-derived mesenchymal stem cells (WJ-MSCs) on endothelial cell viability and angiogenesis. The human umbilical vein endothelial cells (HUVECs) were pretreated with WJ-MSCs ECM for 2d/7d/14d, respectively. After pretreatment, the angiogenesis ability of HUVECs was detected. In this study, we found for the first time that WJ-MSCs ECM could improve the angiogenesis ability of HUVECs with a time-dependent manner in vitro. Mechanically, WJ-MSCs ECM activated the focal adhesion kinase (FAK)/P38 signaling pathway via integrin αVβ3, which further promoted the expression of the cellular (c)-Myc. Further, c-Myc increased histone acetylation levels of the vascular endothelial growth factor (VEGF) promoter by recruiting P300, which ultimately promoting VEGF expression. ECM derived from Wharton's Jelly-derived mesenchymal stem cells promotes angiogenesis via integrin αVβ3/c-Myc/P300/VEGF. This study is expected to provide a new approach to promote angiogenesis in bone and tissue regeneration. | 2022 Jul 18 | Stem cell research & therapy | No DOI | [
{
"LastName": "Ma",
"FirstName": "Beilei",
"Affiliation": "Department of Clinical Laboratory, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China."
},
{
"LastName": "Wang",
"FirstName": "Tengkai",
"Affiliation": "Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China."
},
{
"LastName": "Li",
"FirstName": "Juan",
"Affiliation": "Department of Clinical Laboratory, Qilu Hospital of Shandong University (Qingdao), Qingdao, 266035, China."
},
{
"LastName": "Wang",
"FirstName": "Qian",
"Affiliation": "Department of Clinical Laboratory, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. [email protected]."
}
] | No |
38526390 | Restoration of Pregnancy Function Using a GT/PCL Biofilm in a Rabbit Model of Uterine Injury. | Biomaterial scaffolds have been used successfully to promote the regenerative repair of small endometrial lesions in small rodents, providing partial restoration of gestational function. The use of rabbits in this study allowed us to investigate a larger endometrial tissue defect and myometrial injury model. A gelatin/polycaprolactone (GT/PCL) gradient-layer biofilm was sutured at the defect to guide the reconstruction of the original tissue structure. Twenty-eight days postimplantation, the uterine cavity had been restored to its original morphology, endometrial growth was accompanied by the formation of glands and blood vessels, and the fragmented myofibers of the uterine smooth muscle had begun to resemble the normal structure of the lagomorph uterine cavity, arranging in a circular luminal pattern and a longitudinal serosal pattern. In addition, the repair site supported both embryonic implantation into the placenta and normal embryonic development. Four-dimensional label-free proteomic analysis identified the cell adhesion molecules, phagosome, ferroptosis, rap1 signaling pathways, hematopoietic cell lineage, complement and coagulation cascades, tricarboxylic acid cycle, carbon metabolism, and hypoxia inducible factor (HIF)-1 signaling pathways as important in the endogenous repair process of uterine tissue injury, and acetylation of protein modification sites upregulated these signaling pathways. | 2024 Apr 30 | Tissue engineering. Part A | No DOI | [
{
"LastName": "Huang",
"FirstName": "Di",
"Affiliation": "Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, P. R. China."
},
{
"LastName": "Liu",
"FirstName": "Jing",
"Affiliation": "The Affiliated Taian City Central Hospital of Qingdao University, Taian, P. R. China."
},
{
"LastName": "Yang",
"FirstName": "Jie",
"Affiliation": "The Affiliated Taian City Central Hospital of Qingdao University, Taian, P. R. China."
},
{
"LastName": "Liang",
"FirstName": "Junhui",
"Affiliation": "Department of Gynaecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, P. R. China."
},
{
"LastName": "Zhang",
"FirstName": "Jing",
"Affiliation": "Shandong First Medical University, Tai'an, P. R. China."
},
{
"LastName": "Han",
"FirstName": "Qinyu",
"Affiliation": "Shandong First Medical University, Jinan, P. R. China."
},
{
"LastName": "Yu",
"FirstName": "Jianlong",
"Affiliation": "Rizhao People's Hospital, Rizhao, P. R. China."
},
{
"LastName": "Yang",
"FirstName": "Tingting",
"Affiliation": "Tai'an Maternal and Child Health Hospital, Tai'an, P. R. China."
},
{
"LastName": "Meng",
"FirstName": "Qi",
"Affiliation": "The Affiliated Taian City Central Hospital of Qingdao University, Taian, P. R. China."
},
{
"LastName": "Steinberg",
"FirstName": "Thorsten",
"Affiliation": "Division of Oral Biotechnology, Center for Dental Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany."
},
{
"LastName": "Li",
"FirstName": "Changzhong",
"Affiliation": "Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, P. R. China."
},
{
"LastName": "Chang",
"FirstName": "Zhongle",
"Affiliation": "Shandong Agriculture University, Tai'an, P. R. China."
}
] | No |
35652521 | SUMOylation in peripheral tissues under low perfusion-related pathological states. | SUMOylation is described as a posttranslational protein modification (PTM) that is involved in the pathophysiological processes underlying several conditions related to ischemia- and reperfusion-induced damage. Increasing evidence suggests that, under low oxygen levels, SUMOylation might be part of an endogenous mechanism, which is triggered by injury to protect cells within the central nervous system. However, the role of ischemia-induced SUMOylation in the periphery is still unclear. This article summarizes the results of recent studies regarding SUMOylation profiles in several diseases characterized by impaired blood flow to the cardiorenal, gastrointestinal, and respiratory systems. Our review shows that although ischemic injury per se does not always increase SUMOylation levels, as seen in strokes, it seems that in most cases the positive modulation of protein SUMOylation after peripheral ischemia might be a protective mechanism. This complex relationship warrants further investigation, as the role of SUMOylation during hypoxic conditions differs from organ to organ and is still not fully elucidated. | 2022 Jul | Journal of cellular biochemistry | No DOI | [
{
"LastName": "Oliveira",
"FirstName": "Filipe R M B",
"Affiliation": "Department of Pharmacology, School of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianopolis, Santa Catarina, Brazil."
},
{
"LastName": "Soares",
"FirstName": "Ericks S",
"Affiliation": "Department of Pharmacology, School of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianopolis, Santa Catarina, Brazil."
},
{
"LastName": "Harms",
"FirstName": "Christoph",
"Affiliation": "Klinik und Hochschulambulanz für Neurologie mit Experimenteller Neurologie, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany."
},
{
"LastName": "Cimarosti",
"FirstName": "Helena I",
"Affiliation": "Department of Pharmacology, School of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianopolis, Santa Catarina, Brazil."
},
{
"LastName": "Sordi",
"FirstName": "Regina",
"Affiliation": "Department of Pharmacology, School of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianopolis, Santa Catarina, Brazil."
}
] | No |
32418265 | Effects of intrauterine exposure to 2,3',4,4',5-pentachlorobiphenyl on the reproductive system and sperm epigenetic imprinting of male offspring. | Polychlorinated biphenyls (PCBs) are a class of persistent organic environmental pollutants with a total of 209 homologs. The homolog 2,3',4,4',5-pentachlorobiphenyl (PCB118) is one of the most important dioxin-like PCBs and is highly toxic. PCB118 can accumulate in human tissues, serum and breast milk, which leads to direct exposure of the fetus during development. In the present study, pregnant mice were exposed to 0, 20 and 100 μg/kg/day of PCB118 during the stage of fetal primordial germ cell migration. Compared with the control group, we found morphological alterations of the seminiferous tubules and a higher sperm deformity rate in the male offspring in the treatment groups. Furthermore, the methylation patterns in the treatment groups of the imprinted genes H19 and Gtl2 in the sperm were altered in the male offspring. We also characterized the disturbance of the expression levels of DNA methyltransferase 1 (Dnmt1), Dnmt3a, Dnmt3b, Dnmt3l, and Uhrf1. The results indicated that intrauterine exposure to low doses of PCB118 could significantly damage the reproductive health of the male offspring. Therefore, attention should be paid to the adverse effects of PCB118 exposure during pregnancy on the reproductive system of male offspring. | 2020 Oct | Journal of applied toxicology : JAT | No DOI | [
{
"LastName": "He",
"FirstName": "Qi-Long",
"Affiliation": "Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China."
},
{
"LastName": "Lyu",
"FirstName": "Tian-Qi",
"Affiliation": "Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China."
},
{
"LastName": "Zhang",
"FirstName": "Yong-Tao",
"Affiliation": "Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China."
},
{
"LastName": "Wang",
"FirstName": "Hai-Quan",
"Affiliation": "Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China."
},
{
"LastName": "Zhou",
"FirstName": "Qian",
"Affiliation": "State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China."
},
{
"LastName": "Zhang",
"FirstName": "Jian-Mei",
"Affiliation": "Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China."
},
{
"LastName": "Liu",
"FirstName": "Yuan-Yuan",
"Affiliation": "Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China."
},
{
"LastName": "Li",
"FirstName": "Jia-Shuo",
"Affiliation": "Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China."
},
{
"LastName": "Jiang",
"FirstName": "Li-Gang",
"Affiliation": "Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China."
},
{
"LastName": "Cheng",
"FirstName": "Dong",
"Affiliation": "Department of Toxicology, Shandong Center for Disease Control and Prevention, Jinan, China."
},
{
"LastName": "Ge",
"FirstName": "Zhao-Jia",
"Affiliation": "College of Life Sciences, Institute of Reproductive Sciences, Qingdao Agricultural University, Qingdao, China."
},
{
"LastName": "Liu",
"FirstName": "Shu-Zhen",
"Affiliation": "Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, China."
}
] | No |
38961021 | Sustainable methanol production from carbon dioxide: advances, challenges, and future prospects. | The urgent need to address global carbon emissions and promote sustainable energy solutions has led to a growing interest in carbon dioxide (CO2) conversion technologies. Among these, the transformation of CO2 into methanol (MeOH) has gained prominence as an effective mitigation strategy. This review paper provides a comprehensive exploration of recent advances and applications in the direct utilization of CO2 for the synthesis of MeOH, encompassing various aspects from catalysts to market analysis, environmental impact, and future prospects. We begin by introducing the current state of CO2 mitigation strategies, highlighting the significance of carbon recycling through MeOH production. The paper delves into the chemistry and technology behind the conversion of CO2 into MeOH, encompassing key themes such as feedstock selection, material and energy supply, and the various conversion processes, including chemical, electrochemical, photochemical, and photoelectrochemical pathways. An in-depth analysis of heterogeneous and homogeneous catalysts for MeOH synthesis is provided, shedding light on the advantages and drawbacks of each. Furthermore, we explore diverse routes for CO2 hydrogenation into MeOH, emphasizing the technological advances and production processes associated with this sustainable transformation. As MeOH holds a pivotal role in a wide range of chemical applications and emerges as a promising transportation fuel, the paper explores its various chemical uses, transportation, storage, and distribution, as well as the evolving MeOH market. The environmental and energy implications of CO2 conversion to MeOH are discussed, including a thermodynamic analysis of the process and cost and energy evaluations for large-scale catalytic hydrogenation. | 2024 Jul | Environmental science and pollution research international | No DOI | [
{
"LastName": "Patil",
"FirstName": "Tushar",
"Affiliation": "Centre for Sustainable Technologies, Department of Chemical Engineering, School of Energy Technology, Pandit Deendayal Energy University, Raisan, Gandhinagar, Gujarat, 390019, India."
},
{
"LastName": "Naji",
"FirstName": "Arkan",
"Affiliation": "Centre for Sustainable Technologies, Department of Chemical Engineering, School of Energy Technology, Pandit Deendayal Energy University, Raisan, Gandhinagar, Gujarat, 390019, India."
},
{
"LastName": "Mondal",
"FirstName": "Ujjal",
"Affiliation": "Sustainability Centre of Excellence, Larsen & Toubro Technology Services, Vadodara, Gujarat, 382426, India."
},
{
"LastName": "Pandey",
"FirstName": "Indu",
"Affiliation": "Larsen & Toubro Technology Services, Larsen & Toubro Tech Park, Byatarayanapura, Bengaluru, Karnataka, 560092, India."
},
{
"LastName": "Unnarkat",
"FirstName": "Ashish",
"Affiliation": "Centre for Sustainable Technologies, Department of Chemical Engineering, School of Energy Technology, Pandit Deendayal Energy University, Raisan, Gandhinagar, Gujarat, 390019, India."
},
{
"LastName": "Dharaskar",
"FirstName": "Swapnil",
"Affiliation": "Centre for Sustainable Technologies, Department of Chemical Engineering, School of Energy Technology, Pandit Deendayal Energy University, Raisan, Gandhinagar, Gujarat, 390019, India. [email protected]."
}
] | No |
35082917 | Experience Mode of Digital Media Art under Virtual Reality Technology. | With the progress of the country's comprehensive strength and scientific strength, the development of science and technology has brought tremendous changes to people's lives and at the same time brought information dissemination and media methods to a new stage. This article integrates VR technology into your digital media art experience. This combination not only reduces the distance between the experience and the art but also allows the experiencers to better understand what the artist wants to convey in the artwork. Virtual reality technologies and experts have shifted from bystanders to participants and experiencers. This is a brand new experience. It dispels our previous experience based on visual experience and forms a new form of experience. The final results of the study showed that the scores of the three classes of cognitive experience were 4.8, 4.6, and 4.7, with an average score of 4.7. With a full score of 5, the scores in the three dimensions are very high, indicating that this digital media art interactive experience design has brought students a good sensory experience, interactive experience, and cognitive experience. | 2022 | Applied bionics and biomechanics | No DOI | [
{
"LastName": "Wu",
"FirstName": "Xingming",
"Affiliation": "Visual Communication Department of Art College, Zhejiang Shuren University, Hangzhou, 310015 Zhejiang, China."
},
{
"LastName": "Li",
"FirstName": "Yehan",
"Affiliation": "School of Art and Design, Zhejiang Business College, Hangzhou, 310053 Zhejiang, China."
}
] | Yes |
33585013 | Prevalence of astrovirus, adenovirus, and sapovirus infections among Iranian children with acute gastroenteritis. | This study aimed to determine the prevalence of Human Astroviruses (HAstVs), enteric Adenoviruses (HAdVs), and Sapoviruses (SaVs) in acute diarrhea patients, as well as their relation to age, sex, and season. Acute gastroenteritis is one of the most common diseases affecting children <5 years old and viral agents with approximately >75% are the major causative agent of acute infectious diarrhea. After Rotavirus and Norovirus, the greater viral agents of acute gastroenteritis include HAstVs, HAdVs, and SaVs. To the best of our knowledge, there are sparse studies in Iran detecting at least three enteric viruses as causative agents of diarrhea simultaneously. The sample was collected from children referring to pediatric medical centers in Tehran, Iran; they were tested for Astrovirus, enteric Adenovirus, and Sapovirus by conventional PCR method. The association of incidence of viral enteric agents was evaluated with age, sex and seasonal pattern in children <5 years old. The positive case number among acute gastroenteritis patients was 17/120 (14.1%). Patients ranged in age within 1-60 months, but 52.9% were aged ≤ 12 months. Males comprised the majority (70.6), and the male: female ratio was 2.4. HAstV was the most frequently detected virus (6.7%), while SaVs were detected only in 2.5% of cases. Mixed infections were not detected in these samples. The highest rate of HAstV was identified in winter (66.7%), HAdV in fall (66.7%), and SaV in winter (33.3%). These findings underscore the importance of monitoring the epidemiology of HAstV, HAdV, and SaV as causative agents of viral diarrhea infections. | 2020 Winter | Gastroenterology and hepatology from bed to bench | No DOI | [
{
"LastName": "Mousavi Nasab",
"FirstName": "Seyed Dawood",
"Affiliation": "Department of Research and Development, Production and Research Complex, Pasteur Institute of Iran."
},
{
"LastName": "Zali",
"FirstName": "Fatemeh",
"Affiliation": "Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran."
},
{
"LastName": "Kaghazian",
"FirstName": "Hooman",
"Affiliation": "Department of Research and Development, Production and Research Complex, Pasteur Institute of Iran."
},
{
"LastName": "Aghasadeghi",
"FirstName": "Mohammad Reza",
"Affiliation": "Department of Research and Development, Production and Research Complex, Pasteur Institute of Iran."
},
{
"LastName": "Mardani",
"FirstName": "Rajab",
"Affiliation": "Department of Viral vaccines, Pasteur Institute of Iran, Tehran."
},
{
"LastName": "Gachkar",
"FirstName": "Latif",
"Affiliation": "Infectious Diseases and Tropical Medicine Research Center, Infectious Diseases Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."
},
{
"LastName": "Ahmadi Vasmehjani",
"FirstName": "Abbas",
"Affiliation": "Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran."
},
{
"LastName": "Ahmadi",
"FirstName": "Nayebali",
"Affiliation": "Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran."
},
{
"LastName": "Ghasemzadeh",
"FirstName": "Ali",
"Affiliation": "Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran."
}
] | No |
28228930 | Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis. | Although endovascular stenting has been used as an interventional therapy to treat cardio- and cerebro-vascular diseases, it is associated with recurrent vascular diseases following stent thrombosis and in-stent restenosis. In this study, a metallic stent was coated with dopamine-conjugated hyaluronic acid with different ratios of catechol group to improve hemocompatibility and re-endothelialization. Especially, we were interested in how much amount of catechol group is appropriate for the above-mentioned purposes. Therefore, a series of dopamine-conjugated hyaluronic acid conjugates with different ratios of catechol group were synthesized via a carbodiimide coupling reaction. Dopamine-conjugated hyaluronic acid conjugates were characterized with [1]H-nuclear magnetic resonance and Fourier transform infrared spectroscopy, and the amount of catechol group in dopamine-conjugated hyaluronic acid was measured by ultraviolet spectrometer. Co-Cr substrates were polished and coated with various dopamine-conjugated hyaluronic acid conjugates under pH 8.5. Dopamine-conjugated hyaluronic acid amounts on the substrate were quantified by micro-bicinchoninic acid assay. Surface characteristics of dopamine-conjugated hyaluronic-acid-coated Co-Cr were evaluated by water contact angle, scanning electron microscopy, and atomic force microscopy. The hemocompatibility of the surface-modified substrates was assessed by protein adsorption and platelet adhesion tests. Adhesion and activation of platelets were confirmed with scanning electron microscopy and lactate dehydrogenase assay. Human umbilical vein endothelial cells were cultured on the substrates, and the viability, adhesion, and proliferation were investigated through cell counting kit-8 assay and fluorescent images. Obtained results demonstrated that optimal amounts of catechol group (100 µmol) in the dopamine-conjugated hyaluronic acid existed in terms of various properties such as hemocompatibility and cellular responses. | 2016 Jan-Dec | Journal of tissue engineering | No DOI | [
{
"LastName": "Lih",
"FirstName": "Eugene",
"Affiliation": "Center for Biomaterials, Korea Institute of Science and Technology, Seoul, Korea."
},
{
"LastName": "Choi",
"FirstName": "Seul Gi",
"Affiliation": "Center for Biomaterials, Korea Institute of Science and Technology, Seoul, Korea; Department of Biomicrosystem Technology, Korea University, Seoul, Korea; Department of Chemical & Biological Engineering, Korea University, Seoul, Korea."
},
{
"LastName": "Ahn",
"FirstName": "Dong June",
"Affiliation": "Department of Biomicrosystem Technology, Korea University, Seoul, Korea; Department of Chemical & Biological Engineering, Korea University, Seoul, Korea; KU-KIST Graduate School of Converging Science and Engineering, Korea University, Seoul, Korea."
},
{
"LastName": "Joung",
"FirstName": "Yoon Ki",
"Affiliation": "Center for Biomaterials, Korea Institute of Science and Technology, Seoul, Korea; Department of Biomedical Engineering, Korea University of Science and Technology, Daejeon, Korea."
},
{
"LastName": "Han",
"FirstName": "Dong Keun",
"Affiliation": "Center for Biomaterials, Korea Institute of Science and Technology, Seoul, Korea; Department of Biomedical Engineering, Korea University of Science and Technology, Daejeon, Korea."
}
] | No |
38893316 | Hydroxyl Group as the 'Bridge' to Enhance the Single-Molecule Conductance by Hyperconjugation. | For designing single-molecule devices that have both conjugation systems and structural flexibility, a hyperconjugated molecule with a σ-π bond interaction is considered an ideal candidate. In the investigation of conductance at the single-molecule level, since few hyperconjugation systems have been involved, the strategy of building hyperconjugation systems and the mechanism of electron transport within this system remain unexplored. Based on the skipped-conjugated structure, we present a rational approach to construct a hyperconjugation molecule using a hydroxyl group, which serves as a bridge to interact with the conjugated fragments. The measurement of single-molecule conductance reveals a two-fold conductance enhancement of the hyperconjugation system having the 'bridging' hydroxyl group compared to hydroxyl-free derivatives. Theoretical studies demonstrate that the hydroxyl group in the hyperconjugation system connects the LUMO of the two conjugated fragments and opens a through-space channel for electron transport to enhance the conductance. | 2024 May 22 | Molecules (Basel, Switzerland) | No DOI | [
{
"LastName": "Lv",
"FirstName": "Xin",
"Affiliation": "Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China."
},
{
"LastName": "Li",
"FirstName": "Chang",
"Affiliation": "Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China."
},
{
"LastName": "Guo",
"FirstName": "Meng-Meng",
"Affiliation": "Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China."
},
{
"LastName": "Hong",
"FirstName": "Wenjing",
"Affiliation": "State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China."
},
{
"LastName": "Chen",
"FirstName": "Li-Chuan",
"Affiliation": "State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China."
},
{
"LastName": "Zhang",
"FirstName": "Qian-Chong",
"Affiliation": "Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China."
},
{
"LastName": "Chen",
"FirstName": "Zhong-Ning",
"Affiliation": "Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China."
}
] | No |
31347328 | Accuracy and Efficacy of Impedance Cardiography as a Non-Invasive Cardiac Function Monitor. | The most common method of monitoring cardiac output (CO) is thermodilution using pulmonary artery catheter (PAC), but this method is associated with complications. Impedance cardiography (ICG) is a non-invasive CO monitoring technique. This study compared the accuracy and efficacy of ICG as a non-invasive cardiac function monitoring technique to those of thermodilution and arterial pressure contour. Sixteen patients undergoing liver transplantation were included. Cardiac index (CI) was measured by thermodilution using PAC, arterial waveform analysis, and ICG simultaneously in each patient. Statistical analysis was performed using intraclass correlation coefficient (ICC) and Bland-Altman analysis to assess the degree of agreement. The difference by thermodilution and ICG was 1.13 L/min/m², and the limits of agreement were -0.93 and 3.20 L/min/m². The difference by thermodilution and arterial pressure contour was 0.62 L/min/m², and the limits of agreement were -1.43 and 2.67 L/min/m². The difference by arterial pressure contour and ICG was 0.50 L/min/m², and the limits of agreement were -1.32 and 2.32 L/min/m². All three percentage errors exceeded the 30% limit of acceptance. Substantial agreement was observed between CI of thermodilution with PAC and ICG at preanhepatic and anhepatic phases, as well as between CI of thermodilution and arterial waveform analysis at preanhepatic phase. Others showed moderate agreement. Although neither method was clinically equivalent to thermodilution, ICG showed more substantial correlation with thermodilution method than with arterial waveform analysis. As a non-invasive cardiac function monitor, ICG would likely require further studies in other settings. | 2019 Aug | Yonsei medical journal | No DOI | [
{
"LastName": "Kim",
"FirstName": "Go Eun",
"Affiliation": "Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea."
},
{
"LastName": "Kim",
"FirstName": "So Yeon",
"Affiliation": "Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea."
},
{
"LastName": "Kim",
"FirstName": "Seon Ju",
"Affiliation": "Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea."
},
{
"LastName": "Yun",
"FirstName": "Soon Young",
"Affiliation": "Department of Anesthesiology and Pain Medicine, Gachon University Gil Medical Center, Incheon, Korea."
},
{
"LastName": "Jung",
"FirstName": "Hwan Ho",
"Affiliation": "Department of Anesthesiology and Pain Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea."
},
{
"LastName": "Kang",
"FirstName": "Yhen Seung",
"Affiliation": "Department of Anesthesiology and Pain Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea."
},
{
"LastName": "Koo",
"FirstName": "Bon Nyeo",
"Affiliation": "Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea. [email protected]."
}
] | No |
35302608 | Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist-Treated Prostate Cancers. | Inhibiting androgen signaling using androgen signaling inhibitors (ASI) remains the primary treatment for castrate-resistant prostate cancer. Acquired resistance to androgen receptor (AR)-targeted therapy represents a major impediment to durable clinical response. Understanding resistance mechanisms, including the role of AR expressed in other cell types within the tumor microenvironment, will extend the clinical benefit of AR-targeted therapy. Here, we show the ASI enzalutamide induces vascular catastrophe and promotes hypoxia and microenvironment adaptation. We characterize treatment-induced hypoxia, and subsequent induction of angiogenesis, as novel mechanisms of relapse to enzalutamide, highlighting the importance of two hypoxia-regulated cytokines in underpinning relapse. We confirmed AR expression in CD34+ vascular endothelium of biopsy tissue and human vascular endothelial cells (HVEC). Enzalutamide attenuated angiogenic tubule formation and induced cytotoxicity in HVECs in vitro, and rapidly induced sustained hypoxia in LNCaP xenografts. Subsequent reoxygenation, following prolonged enzalutamide treatment, was associated with increased tumor vessel density and accelerated tumor growth. Hypoxia increased AR expression and transcriptional activity in prostate cells in vitro. Coinhibition of IL8 and VEGF-A restored tumor response in the presence of enzalutamide, confirming the functional importance of their elevated expression in enzalutamide-resistant models. Moreover, coinhibition of IL8 and VEGF-A resulted in a durable, effective resolution of enzalutamide-sensitive prostate tumors. We conclude that concurrent inhibition of two hypoxia-induced factors, IL8 and VEGF-A, prolongs tumor sensitivity to enzalutamide in preclinical models and may delay the onset of enzalutamide resistance. Targeting hypoxia-induced signaling may extend the therapeutic benefit of enzalutamide, providing an improved treatment strategy for patients with resistant disease. | 2022 Jun 3 | Molecular cancer research : MCR | No DOI | [
{
"LastName": "Maxwell",
"FirstName": "Pamela J",
"Affiliation": "Movember FASTMAN Centre of Excellence, Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom."
},
{
"LastName": "McKechnie",
"FirstName": "Melanie",
"Affiliation": "Movember FASTMAN Centre of Excellence, Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom."
},
{
"LastName": "Armstrong",
"FirstName": "Christopher W",
"Affiliation": "Movember FASTMAN Centre of Excellence, Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom."
},
{
"LastName": "Manley",
"FirstName": "Judith M",
"Affiliation": "Movember FASTMAN Centre of Excellence, Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom."
},
{
"LastName": "Ong",
"FirstName": "Chee Wee",
"Affiliation": "Movember FASTMAN Centre of Excellence, Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom."
},
{
"LastName": "Worthington",
"FirstName": "Jenny",
"Affiliation": "Axis Biosciences, Coleraine, Northern Ireland, United Kingdom."
},
{
"LastName": "Mills",
"FirstName": "Ian G",
"Affiliation": "Movember FASTMAN Centre of Excellence, Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom."
},
{
"LastName": "Longley",
"FirstName": "Daniel B",
"Affiliation": "Movember FASTMAN Centre of Excellence, Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom."
},
{
"LastName": "Quigley",
"FirstName": "James P",
"Affiliation": "Department of Cell Biology, The Scripps Research Institute, La Jolla, California."
},
{
"LastName": "Zoubeidi",
"FirstName": "Amina",
"Affiliation": "The Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada."
},
{
"LastName": "de Bono",
"FirstName": "Johann S",
"Affiliation": "Division of Clinical Studies, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom."
},
{
"LastName": "Deryugina",
"FirstName": "Elena",
"Affiliation": "Department of Cell Biology, The Scripps Research Institute, La Jolla, California."
},
{
"LastName": "LaBonte",
"FirstName": "Melissa J",
"Affiliation": "Movember FASTMAN Centre of Excellence, Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom."
},
{
"LastName": "Waugh",
"FirstName": "David J J",
"Affiliation": "Movember FASTMAN Centre of Excellence, Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom."
}
] | No |
39018869 | Analysis of mechanism, therapeutic strategies, and potential natural compounds against atherosclerosis by targeting iron overload-induced oxidative stress. | Ferroptosis is a novel form of cell demise characterized primarily by the reduction of trivalent iron to divalent iron, leading to the release of reactive oxygen species (ROS) and consequent induction of intense oxidative stress. In atherosclerosis (AS), highly accumulated lipids are modified by ROS to promote the formation of lipid peroxides, further amplifying cellular oxidative stress damage to influence all stages of atherosclerotic development. Macrophages are regarded as pivotal executors in the progression of AS and the handling of iron, thus targeting macrophage iron metabolism holds significant guiding implications for exploring potential therapeutic strategies against AS. In this comprehensive review, we elucidate the potential interplay among iron overload, inflammation, and lipid dysregulation, summarizing the potential mechanisms underlying the suppression of AS by alleviating iron overload. Furthermore, the application of Traditional Chinese Medicine (TCM) is increasingly widespread. Based on extant research and the pharmacological foundations of active compounds of TCM, we propose alternative therapeutic agents for AS in the context of iron overload, aiming to diversify the therapeutic avenues. | 2024 Aug | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | No DOI | [
{
"LastName": "Zhang",
"FirstName": "Jing",
"Affiliation": "Tianjin State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China."
},
{
"LastName": "Nie",
"FirstName": "Chunxia",
"Affiliation": "Tianjin State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China."
},
{
"LastName": "Zhang",
"FirstName": "Yang",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China."
},
{
"LastName": "Yang",
"FirstName": "Lina",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China."
},
{
"LastName": "Du",
"FirstName": "Xinke",
"Affiliation": "Tianjin State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China."
},
{
"LastName": "Liu",
"FirstName": "Li",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China."
},
{
"LastName": "Chen",
"FirstName": "Ying",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China."
},
{
"LastName": "Yang",
"FirstName": "Qing",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China."
},
{
"LastName": "Zhu",
"FirstName": "Xiaoxin",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China. Electronic address: [email protected]."
},
{
"LastName": "Li",
"FirstName": "Qi",
"Affiliation": "Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China; State key laboratory for quality ensurance and sustainable use ofdao-di herbs, Beijing 100700, China. Electronic address: [email protected]."
}
] | No |
34346146 | Comparing pre- and post-treatment patients' perceptions on dental implant therapy. | Appropriate patients' perceptions as one of Patient Reported Outcome Measures (PROMs), are shown to be critical for the sustainable success of implant therapy, little is known however of how they prospectively evolve throughout the treatment process. This study aimed to prospectively assess patients' perceptions before and after treatment with dental implants and to identify the impact of patients' characteristics on their perceptions. Patients' perceptions on implant therapy were prospectively assessed by means of purpose-made questionnaire, rating the extent of agreement/disagreement with a set of statements on a visual analog scale. The questionnaire was collected before initial consultation with the implant dentist and post-treatment at least 1 month after prosthetic loading of the implant. Changes in patients' perceptions were analyzed with the Wilcoxon signed-rank test. Pretreatment questionnaire was collected from 359 patients. While 245 of them proceeded with implant therapy, 145 received final restoration within the timeframe of the study and completed the post-treatment questionnaires between 1 and 6 months after prosthesis delivery. The most common source of information was dental professions (72.4%). Although patients' perceptions were more realistic at post-treatment, few improper perceptions persisted as only 51% of patients agreed with the statement "There is a chance of dental implant failure," 28% agreed with the statement "Dental implants last longer than natural teeth," and higher percentage of patients agreed with "Dental implant therapy is appropriate for all patients." Although patients appear to harbor more realistic perceptions of implant therapy, certain improper perceptions still persist at post-treatment. The design of appropriate patient educational program might be essential to correct misperceptions that might affect long term success of implant therapy. This study had been registered on Thai Clinical Trials Registry (TCTR) with the TCTR identification number: TCTR20181101001. | 2021 Oct | Clinical implant dentistry and related research | No DOI | [
{
"LastName": "Sermsiripoca",
"FirstName": "Khunsiri",
"Affiliation": "Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand."
},
{
"LastName": "Pisarnturakit",
"FirstName": "Pagaporn Pantuwadee",
"Affiliation": "Department of Community Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand."
},
{
"LastName": "Mattheos",
"FirstName": "Nikos",
"Affiliation": "Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand."
},
{
"LastName": "Pimkhaokham",
"FirstName": "Atiphan",
"Affiliation": "Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand."
},
{
"LastName": "Subbalekha",
"FirstName": "Keskanya",
"Affiliation": "Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand."
}
] | No |
31517732 | Oridonin inhibits hypoxia-induced epithelial-mesenchymal transition and cell migration by the hypoxia-inducible factor-1α/matrix metallopeptidase-9 signal pathway in gallbladder cancer. | Hypoxia has crucial roles in cancer development and progression. Our previous study indicated that cell migration was increased in a hypoxic microenvironment in GBC-SD gallbladder cancer (GBC) cells. Oridonin, a bioactive diterpenoid compound that is isolated from the plant Rabdosia rubescens, has been identified as an anticancer agent in various types of cancer. However, its roles in cell proliferation, apoptosis, and migration in a hypoxic microenvironment and the associated regulatory mechanisms have not yet to be fully elucidated in GBC. The present study investigated the effect of oridonin on cell proliferation, apoptosis, the cell cycle and cell migration in GBC in vitro and in vivo. Furthermore, the role of oridonin in hypoxia-induced cell migration and its underlying mechanisms were explored in GBC. The results indicated that treatment with oridonin significantly suppressed cell proliferation and the metastatic ability of GBC-SD cells in a dose-dependent manner, increased the level of cell apoptosis and induced cell cycle arrest at the G0/G1 phase. Further experiments demonstrated that oridonin could inhibit hypoxia-induced epithelial-mesenchymal transition and cell migration by downregulating the expression levels of hypoxia-inducible factor (HIF)-1α/matrix metallopeptidase (MMP)-9. In addition, oridonin suppressed GBC cell growth and downregulated the expression levels of HIF-1α and MMP-9 in a GBC-SD cell xenograft model. Taken together, these results suggest that oridonin possesses anticancer properties in GBC. Notably, oridonin can suppress tumor epithelial-mesenchymal transition and cell migration by targeting the HIF-1α/MMP-9 signaling pathway. | 2019 Oct | Anti-cancer drugs | No DOI | [
{
"LastName": "Chen",
"FirstName": "Kunlun",
"Affiliation": "Departments of Hepatobiliary and Pancreatic Surgery."
},
{
"LastName": "Ye",
"FirstName": "Jianwen",
"Affiliation": "Departments of Hepatobiliary and Pancreatic Surgery."
},
{
"LastName": "Qi",
"FirstName": "Lei",
"Affiliation": "Pharmacy, The First Affiliated Hospital of Zhengzhou University."
},
{
"LastName": "Liao",
"FirstName": "Yuan",
"Affiliation": "Departments of Hepatobiliary and Pancreatic Surgery."
},
{
"LastName": "Li",
"FirstName": "Renfeng",
"Affiliation": "Departments of Hepatobiliary and Pancreatic Surgery."
},
{
"LastName": "Song",
"FirstName": "Shengping",
"Affiliation": "Departments of Hepatobiliary and Pancreatic Surgery."
},
{
"LastName": "Zhou",
"FirstName": "Chuang",
"Affiliation": "Departments of Hepatobiliary and Pancreatic Surgery."
},
{
"LastName": "Feng",
"FirstName": "Ruo",
"Affiliation": "Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China."
},
{
"LastName": "Zhai",
"FirstName": "Wenlong",
"Affiliation": "Departments of Hepatobiliary and Pancreatic Surgery."
}
] | No |
29137467 | Evaluation of Serum Copper Level in Naswar (Smokeless Tobacco) Addicts Using Flame Atomic Absorption Spectroscopy. | Substance abuse and its consequences are a matter of great concern in South-East Asian countries, especially Pakistan and Afghanistan. Due to contamination of Naswar with copper, or by any other physiological mechanism, there is a great chance of copper poisoning in addicts. Keeping in view the literature, there is no comparative study on serum copper levels (SCuL) in Naswar addicts. Therefore, it is very important to evaluate SCuL in this population. The current study was performed in September 2016 where a total of 75 volunteers (selected from villages near the University of Peshawar, Pakistan) were grouped as Naswar addicts (n = 45) and the control group (n = 30). The addicts were compared to controls for age, weight, BMI, FBS and creatinine clearance. For serum analysis, about 3mL of blood was collected from which the serum was separated, digested, and then evaluated for SCuL using flame atomic absorption spectroscopy at the Department of Pharmacy and Centralized Resource Laboratory of University of Peshawar. The SCuL in addicts had a range of 2.6 to 11.1 µg/dL with a mean of 5.1 ± 2.4 µg/dL. In the healthy control group, SCuL was between 1.7 to 3.9 µg/dL with a mean of 2.6 ±0.1 µg/dL. The mean difference between the two study groups was statistically significant (P = 0.005); the duration of addiction and quantity of drug consumptions per day correlated positively with SCuL. Serum level of copper in Naswar addicts is elevated compared to the Control group. The exact cause of SCuL elevations and the mechanisms involved must be studied in large group samples. | 2017 Oct | Archives of Iranian medicine | No DOI | [
{
"LastName": "Ullah",
"FirstName": "Asmat",
"Affiliation": "Department of Pharmacy, University of Swabi, Swabi, KP, Pakistan."
},
{
"LastName": "Khan",
"FirstName": "Abad",
"Affiliation": "Department of Pharmacy, University of Swabi, Swabi, KP, Pakistan."
},
{
"LastName": "Iqbal",
"FirstName": "Zafar",
"Affiliation": "Department of Pharmacy, University of Peshawar, Peshawar, KP, Pakistan."
},
{
"LastName": "Khan",
"FirstName": "Ismail",
"Affiliation": "Department of Pharmacy, University of Peshawar, Peshawar, KP, Pakistan."
}
] | No |
38389126 | ARRDC3 regulates the targeted therapy sensitivity of clear cell renal cell carcinoma by promoting AXL degradation. | AXL plays crucial roles in the tumorigenesis, progression, and drug resistance of neoplasms; however, the mechanisms associated with AXL overexpression in tumors remain largely unknown. In this study, to investigate these molecular mechanisms, wildtype and mutant proteins of arrestin domain-containing protein 3 (ARRDC3) and AXL were expressed, and co-immunoprecipitation analyses were performed. ARRDC3-deficient cells generated using the CRISPR-Cas9 system were treated with different concentrations of the tyrosine kinase inhibitor sunitinib and subjected to cell biological, molecular, and pharmacological experiments. Furthermore, immunohistochemistry was used to analyze the correlation between ARRDC3 and AXL protein expressions in renal cancer tissue specimens. The experimental results demonstrated that ARRDC3 interacts with AXL to promote AXL ubiquitination and degradation, followed by the negative regulation of downstream signaling mechanisms, including the phosphorylation of protein kinase B and extracellular signal-regulated kinase. Notably, ARRDC3 deficiency decreased the sunitinib sensitivity of clear cell renal cell carcinoma (ccRCC) cells in a manner dependent on the regulation of AXL stability. Overall, our results suggest that ARRDC3 is a negative regulator of AXL and can serve as a novel predictor of sunitinib therapeutic response in patients with ccRCC. | 2024 Jan | Cell cycle (Georgetown, Tex.) | No DOI | [
{
"LastName": "Chen",
"FirstName": "Mulin",
"Affiliation": "Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China."
},
{
"LastName": "Yin",
"FirstName": "Bingde",
"Affiliation": "Department of Urology, Minhang Hospital, Fudan University, Shanghai, P.R. China."
},
{
"LastName": "Liu",
"FirstName": "Yao",
"Affiliation": "School of Life Sciences, Fudan University, Shanghai, P.R. China."
},
{
"LastName": "Li",
"FirstName": "Mingzi",
"Affiliation": "Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China."
},
{
"LastName": "Shen",
"FirstName": "Suqin",
"Affiliation": "School of Life Sciences, Fudan University, Shanghai, P.R. China."
},
{
"LastName": "Wu",
"FirstName": "Jiaxue",
"Affiliation": "School of Life Sciences, Fudan University, Shanghai, P.R. China."
},
{
"LastName": "Li",
"FirstName": "Weiguo",
"Affiliation": "Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China."
},
{
"LastName": "Fan",
"FirstName": "Jie",
"Affiliation": "Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China."
}
] | No |
26753208 | [Prediction of response to TNF-α inhibitors treatment with use of swollen to tender joint count ratio (STR)]. | STR is swollen to tender joint count ratio. The aim of this study was to determine the usefulness of STR in predicting response to treatment with biological agents in patients with RA. The study included 27 biologically naive patients treated with TNF inhibitors: infliximab (6), etanercept (10), adalimumab (5) and certolizumab (6). STR index was assessed at baseline and after 3 and 9 months (m) . Patients due to the STR value were divided into two groups: group1 with value of STR < 1 and group 2 with value of STR ≥ 1. Group 1 included 18 patients (17 F, 1 M). Group 2 consisted of 9 persons (7 F 2 M). At the beginning of the observation the average values for the group 1 were: the number of swollen joints (SJ) 6/28 (2-14), the number of tender joints (TJ) 11/28 (5-21), STR 0.46 (0.2-0.9), CRP 27.8 mg/I (1-130.2), DAS28 4.95 (4.03-7.56), disease activity VAS 50 mm (20-75), ESR 35 (8-95). In group 1, the DAS28 improved after 3 months on average - 1.68 (0.08-3.91) and ESR decreased about 16 mm. On the assessment after 9 months of treatment DAS 28 improved on average - 2.89 (0.74-5.17); ESR dropped by 21 mm compared to the baseline. At the beginning of the observation average values for group 2 were: SJ 13/28 (8-19), TJ 19 (4-15), STR 1.48 (1-2.5), CRP 19.27 (7.7-32.1), DAS28 5.75 (5.25-6.47), disease activity - VAS 57 mm (47-66), ESR 25 (14-41). After 3 months of treatment DAS28 reduced on average - 2.52 (1.97-3.71), ESR decreased circa 11 mm. Six patients from group 2 were evaluated after 9 months of treatment. There was observed improvement both in DA528 on average 3.28 (1.86-3.95) and ESR, which dropped by 10 mm. Patients with >1 STR achieved greater improvement in DAS28 after 3 m (p=0.0395) and after 9 months (Ns) compared to patients with STR <1. However, decrease of ESR was higher both after 3 and 9 months in patients with STR <1. We conclude that the STR may be useful in predicting response to treatment with TNF inhibitors. | 2015 | Wiadomosci lekarskie (Warsaw, Poland : 1960) | No DOI | [
{
"LastName": "Kardas",
"FirstName": "Tobiasz",
"Affiliation": ""
},
{
"LastName": "Majdan",
"FirstName": "Maria",
"Affiliation": ""
},
{
"LastName": "Gągoł",
"FirstName": "Danuta",
"Affiliation": ""
},
{
"LastName": "Mazurek",
"FirstName": "Marcin",
"Affiliation": ""
}
] | No |
14530932 | Prophylactic antiemetic therapy with droperidol in patients undergoing laparoscopic cholecystectomy. | The incidence of postoperative nausea and vomiting (PONV) following laparoscopic cholecystectomy (LC) is relatively high when no prophylactic antiemetic is given. We have studied the efficacy of a commonly used and well-established antiemetic, droperidol, for the prevention of PONV in patients undergoing LC. In a randomized, double-blind, placebo-controlled study, 60 patients received placebo (saline) or droperidol 50 microg.kg(-1) (maximum dose, 2.5 mg) intravenously immediately before the induction of anesthesia (n = 30 of each). A standard general anesthetic technique was employed throughout. A complete response, defined as no PONV and no need for another rescue antiemetic medication during the first 24 h after anesthesia, was 57% and 83% in patients who had received placebo and droperidol 50 microg.kg(-1), respectively (P < 0.05). No clinically serious adverse events were observed in any of the groups. Prophylactic antiemetic therapy with droperidol 50 microg.kg(-1) (maximum dose, 2.5 mg) is highly effective for preventing PONV after LC. | 1999 | Journal of anesthesia | No DOI | [
{
"LastName": "Fujii",
"FirstName": "Y",
"Affiliation": "Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, 2-1-1, Amakubo, Tsukuba City, Ibaraki 305, Japan."
},
{
"LastName": "Tanaka",
"FirstName": "H",
"Affiliation": ""
},
{
"LastName": "Toyooka",
"FirstName": "H",
"Affiliation": ""
}
] | Yes |
33726646 | Role of Neuronal Guidance Cues in the Pathophysiology of Obesity: A Peripheral and Central Overview. | Obesity is associated with an exacerbated synthesis and secretion of several molecules, which culminates in chronic low-grade inflammation and insulin resistance. Such conditions affect molecular and physiological responses of several organs and, if not resolved, predispose the obese patients to other diseases such as Type 2 diabetes, atherosclerosis, cancer, neural injuries, and cognitive impairments. A microenvironment with an excess of pro-inflammatory cytokines released by different cells, including immune and adipose cells lead to metabolic and non-metabolic diseases during obesity. In this context, the role of neuronal guidance cues named netrin, semaphorin and ephrin is novel. Specifically, the available literature indicates that besides their classic role as molecules that guide the axon to its target site, the neuronal guidance cues exhibit immunomodulatory functions from adipose tissue to the neural environment. In the current narrative review, we discuss the participation of the neuronal guidance cues on the physiology and pathophysiology of obesity. We also discuss the feedback loop of obesity on the netrin, semaphorin and ephrin functions that impair the structure and function of the brain. The integrative view of the neuronal guidance cues can be relevant in designing new treatments focus on attenuating metabolic and immune disorders in obese patients and reduce the risk of acquiring diseases such as Type 2 diabetes, atherosclerosis, cancer, and neural injuries. | 2021 | Current pharmaceutical design | No DOI | [
{
"LastName": "Inoue",
"FirstName": "Daniela S",
"Affiliation": "Post-Graduation Program in Movement Sciences, Department of Physical Education, State University (Unesp), School of Technology and Sciences, Presidente Prudente, 19060-900, São Paulo, Brazil."
},
{
"LastName": "Bin Maideen",
"FirstName": "Mohammad F",
"Affiliation": "The University of Sydney, School of Health Sciences, Faculty of Medicine and Health, NSW, Australia."
},
{
"LastName": "Jiménez-Maldonado",
"FirstName": "Alberto",
"Affiliation": "Facultad de Deportes Campus Ensenada, Universidad Autonoma de Baja California, Mexico."
},
{
"LastName": "Lira",
"FirstName": "Fábio S",
"Affiliation": "Post-Graduation Program in Movement Sciences, Department of Physical Education, State University (Unesp), School of Technology and Sciences, Presidente Prudente, 19060-900, São Paulo, Brazil."
}
] | No |
34221001 | Sustained Auditory Attentional Load Decreases Audiovisual Integration in Older and Younger Adults. | The modulation of attentional load on the perception of auditory and visual information has been widely reported; however, whether attentional load alters audiovisual integration (AVI) has seldom been investigated. Here, to explore the effect of sustained auditory attentional load on AVI and the effects of aging, nineteen older and 20 younger adults performed an AV discrimination task with a rapid serial auditory presentation task competing for attentional resources. The results showed that responses to audiovisual stimuli were significantly faster than those to auditory and visual stimuli (AV > V ≥ A, all p < 0.001), and the younger adults were significantly faster than the older adults under all attentional load conditions (all p < 0.001). The analysis of the race model showed that AVI was decreased and delayed with the addition of auditory sustained attention (no_load > load_1 > load_2 > load_3 > load_4) for both older and younger adults. In addition, AVI was lower and more delayed in older adults than in younger adults in all attentional load conditions. These results suggested that auditory sustained attentional load decreased AVI and that AVI was reduced in older adults. | 2021 | Neural plasticity | No DOI | [
{
"LastName": "Ren",
"FirstName": "Yanna",
"Affiliation": "Department of Psychology, College of Humanities and Management, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China."
},
{
"LastName": "Hou",
"FirstName": "Yawei",
"Affiliation": "Department of Psychology, College of Humanities and Management, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China."
},
{
"LastName": "Huang",
"FirstName": "Jiayu",
"Affiliation": "Department of Psychology, College of Humanities and Management, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China."
},
{
"LastName": "Li",
"FirstName": "Fanghong",
"Affiliation": "Department of Psychology, College of Humanities and Management, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China."
},
{
"LastName": "Wang",
"FirstName": "Tao",
"Affiliation": "Department of Light and Chemical Engineering, Guizhou Light Industry Technical College, Guiyang 550025, China."
},
{
"LastName": "Ren",
"FirstName": "Yanling",
"Affiliation": "Department of Light and Chemical Engineering, Guizhou Light Industry Technical College, Guiyang 550025, China."
},
{
"LastName": "Yang",
"FirstName": "Weiping",
"Affiliation": "Department of Psychology, Faculty of Education, Hubei University, Wuhan 430062, China."
}
] | Yes |
18350035 | Beam shape effects on grating spectrometer resolution. | The collimated optical beam in a grating spectrometer may be circular or elliptical in cross section, so that different parts of the beam illuminate different numbers of grooves on the grating. Here we estimate the consequent loss in spectral resolution relative to that obtained with a beam that illuminates a fixed number of grooves. The effect reduces the intrinsic resolving power of the spectrometer by approximately 15%, exclusive of other contributions such as finite entrance-slit width. | 2000 Sep 1 | Applied optics | No DOI | [
{
"LastName": "Erickson",
"FirstName": "E F",
"Affiliation": "NASA-Ames Research Center, MS 245-6, Moffett Field, California 94035-1000, USA. [email protected]"
},
{
"LastName": "Rabanus",
"FirstName": "D",
"Affiliation": ""
}
] | No |
37406766 | Ccrl2-centred immune-related lncRNA-mRNA co-expression network revealed the local skin immune activation mechanism of moxibustion on adjuvant arthritis mice. | Moxibustion is an important external therapy of traditional medicine that operates on some acupoints on the skin and is usually used for immune-related diseases. However, whether the immune function of the skin, especially the immune-related lncRNAs, contributes to the mechanism of moxibustion remains unclear. Adjuvant arthritis (AA) was induced by injection of Complete Freund's adjuvant (CFA) into the right hind paw of mice. Moxibustion was administered on the Zusanli (ST36) acupoint for 3 weeks. The alteration of foot volume and cytokine concentration in serum was used to evaluate the anti-inflammation effect of moxibustion. CD83 expression in the local skin of ST36 was measured by immunofluorescence staining. Transcriptome RNA sequencing (RNA-seq) and lncRNA-mRNA network analysis were performed to construct a moxibustion-induced Immune-related lncRNA-mRNA co-expression network. qRT-PCR was used to validate the RNA-seq data. Moxibustion at ST36 relieved the foot swelling, decreased the TNF-α and IL-1β concentrations in serum, and obviously increased the CD83 expression at the local skin of ST36. A total of 548 differentially expressed lncRNAs and 520 linked mRNAs were screened out. The significantly and predominately enriched Go term was inflammatory and immune response, and the main pathways related to inflammatory and immune responses include Toll-like receptor, cytokine-cytokine receptor, and MAPK signaling. The immune-related lncRNA-mRNA co-expression network showed 88 lncRNAs and 36 mRNAs, and Ccrl2 is the central hub of this network. Local immune activation is significantly triggered by moxibustion in ST36 of AA mice. The Ccrl2-centered immune-related lncRNA-mRNA co-expression network would be a promising target for decoding the mechanism of moxibustion for immune-related diseases. | 2023 Sep 15 | Life sciences | No DOI | [
{
"LastName": "Li",
"FirstName": "Yifan",
"Affiliation": "School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: [email protected]."
},
{
"LastName": "Yang",
"FirstName": "Peng",
"Affiliation": "School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China."
},
{
"LastName": "Chen",
"FirstName": "Fenglin",
"Affiliation": "School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China."
},
{
"LastName": "Tang",
"FirstName": "Jinfan",
"Affiliation": "School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: [email protected]."
},
{
"LastName": "He",
"FirstName": "Zhaoxuan",
"Affiliation": "School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: [email protected]."
},
{
"LastName": "Yang",
"FirstName": "Zhonghao",
"Affiliation": "School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: [email protected]."
},
{
"LastName": "Weng",
"FirstName": "Li",
"Affiliation": "School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: [email protected]."
},
{
"LastName": "Guo",
"FirstName": "Jing",
"Affiliation": "School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: [email protected]."
},
{
"LastName": "Zeng",
"FirstName": "Li",
"Affiliation": "Department of Rehabilitation, Medical Center Hospital of Qionglai City, Chengdu 611530, China."
},
{
"LastName": "Yin",
"FirstName": "Haiyan",
"Affiliation": "School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China; Acupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu 610075, China. Electronic address: [email protected]."
}
] | No |
31551766 | Five Active Components Compatibility of Astragali Radix and Angelicae Sinensis Radix Protect Hematopoietic Function Against Cyclophosphamide-Induced Injury in Mice and t-BHP-Induced Injury in HSCs. | Although the compatibility of Astragali Radix (AR) and Angelicae Sinensis Radix (ASR) has favorable effect on promoting hematopoiesis in traditional Chinese medicine (TCM), the main active components and pharmacological mechanism are unknown. We investigated the five active components and its mechanisms in vitro and in vivo. Five active components of Astragalus glycosides (AST), Formononetin (FRM), Ferulic acid (FRA), Calycosin (CAL), and Calycosin-7-glucoside (CLG), which could be absorbed in intestinal tract, were detected in this study. The peripheral blood, hematopoietic growth factors (HGFs), and hematopoietic progenitor cells (HPCs) colony were observed to evaluate the effect of these five active components promoting hematopoiesis. Furthermore, hematopoietic stem cell (HSC) proliferation, aging, cycle, and related proteins were detected to explore the mechanism of these five components promoting HSC proliferation. i) The in vivo experiments showed that the combination of the five active components could remarkably increase the number of RBCs, WBCs, PLTs, and content of Hb in peripheral blood and the area of bone marrow hematopoietic tissue, as well as thrombopoietin (TPO), erythropoietin (EPO), granulocyte-macrophage colony stimulating factor (GM-CSF), and colony of CFU-GM, CFU-MK, CFU-E, and BFU-E in serum. Each of these five components promoted the recovery of RBCs and Hb, and increased TPO, CFU-MK, and CFU-E. All components except for AST increased the CFU-GM. FRA increased the number of WBCs, the area of bone marrow hematopoietic tissue, and BFU-E. FRA and AST promoted PLT recovery. FRA and CAL improved the content of GM-CSF. FRA, CAL, and CLG improved the content of EPO. ii) The in vitro experiments showed that FRA, FRM, and AST significantly promoted cell proliferation, reduced the positive rate and G0/G1 cells, and increased G2/M + S cells and the expression of cyclin D1 and CDK4 proteins in aging HSCs. Furthermore, the combination of five components had the best effect. Taken together, the five active components of AST, FRM, FRA, CAL, and CLG were the main pharmacodynamic substances of the AR-ASR compatibility, which promoted hematopoiesis. The combination of them had a synergistic effect. The mechanism of promoting hematopoiesis may be relevant to regulating cyclin-related proteins, promoting cell cycle transformation, and promoting HSC proliferation. | 2019 | Frontiers in pharmacology | No DOI | [
{
"LastName": "Zhang",
"FirstName": "Wei",
"Affiliation": "Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, China."
},
{
"LastName": "Zhu",
"FirstName": "Jia-Huan",
"Affiliation": "Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, China."
},
{
"LastName": "Xu",
"FirstName": "Hao",
"Affiliation": "Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, China."
},
{
"LastName": "Huang",
"FirstName": "Xiao-Ping",
"Affiliation": "Key Laboratory of Colleges and Universities in Hunan Province for Cytobiology and Molecular Biotechnology, Hunan University of Chinese Medicine, Changsha, China."
},
{
"LastName": "Liu",
"FirstName": "Xiao-Dan",
"Affiliation": "Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, China."
},
{
"LastName": "Deng",
"FirstName": "Chang-Qing",
"Affiliation": "Key Laboratory of Colleges and Universities in Hunan Province for Cytobiology and Molecular Biotechnology, Hunan University of Chinese Medicine, Changsha, China."
}
] | Yes |
18033354 | Self-stabilized passive, harmonically mode-locked stretched-pulse erbium fiber ring laser. | We have studied a passive, harmonically mode-locked stretched-pulse erbium fiber ring laser with net positive dispersion that is self-stabilized by gain depletion and electrostriction. Periodic pulses with supermode suppression of >75 dB and picosecond jitter are achieved. The pulses are compressible to 125 fs by external chirp compensation. The repetition rate is 220 MHz, and the average power is as high as 80 mW. | 2002 | Optics letters | No DOI | [
{
"LastName": "Abedin",
"FirstName": "K S",
"Affiliation": ""
},
{
"LastName": "Gopinath",
"FirstName": "J T",
"Affiliation": ""
},
{
"LastName": "Jiang",
"FirstName": "L A",
"Affiliation": ""
},
{
"LastName": "Grein",
"FirstName": "M E",
"Affiliation": ""
},
{
"LastName": "Haus",
"FirstName": "H A",
"Affiliation": ""
},
{
"LastName": "Ippen",
"FirstName": "Erich P",
"Affiliation": ""
}
] | No |
37843359 | Omicron new variant BA.2.86 (Pirola): Epidemiological, biological, and clinical characteristics - a global data-based analysis. | Since December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a threatening situation worldwide. The new variant of SARS-CoV-2, BA.2.86, also known as Pirola, is an Omicron subvariant that causes great concern because it has been found to contain a large number of mutations. This study aims to investigate and identify the biological and clinical characteristics of this threatening new variant of SARS-CoV-2, which is BA.2.86. This observational study was performed in the Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. The literature was searched using the key terms including "SARS-CoV-2, Omicron, BA.2.86, Pirola, epidemiology, clinical characteristics". The data on Omicron BA.2.86 were obtained from the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), the Global Initiative on Sharing All Influenza Data (GSIAD), PubMed, Web of Science, regional ministries, research institutes, and international print media. Initially, 26 documents were identified and 10 documents were included for the data analysis. The information on the prevalence and the biological characteristics of the new variant of SARS-CoV-2, Omicron BA.2.86, was recorded and synthesized for analysis. The Omicron BA.2.86 has been identified in 23 countries with 264 confirmed cases as of September 28, 2023. The number and distribution of these cases encompass the United Kingdom 66 (25.0%), USA 34 (12.87%), Denmark 31 (11.74%), Sweden 25 (9.46%), South Africa 20 (7.57%), Spain 20 (7.57%), France 15 (5.68%), Portugal 7 (2.65%), Japan 6 (2.27%), Canada 5 (1.89%), Thailand 5 (1.89%), Israel 5 (1.89%), Greece 5 (1.89%), Germany 3 (1.13%), Belgium 3 (1.13%), Luxembourg 3 (1.13%), Netherlands 3 (1.13%), South Korea 3 (1.13%). However, one case in each country has been reported in Australia, Italy, Iceland, Switzerland, and China. The disease has been reported more frequently in females (71.0%) than males (29.0%). To date, no deaths have been reported. The novel variant has spread more swiftly than other variants of SARS-CoV-2 and has crossed many international borders. The new Omicron variant BA.2.86 has affected 264 people in 23 countries. The disease is more common in females than males and mainly affects old age people (over 60 years of age). However, no deaths have been reported. The variant is spreading swiftly and transmitted more rapidly. The clinical manifestations in patients with Omicron BA.2.86 variant are not well documented and may be similar to earlier strains of COVID-19 by presenting with mild infectious symptoms, including headache, body ache, cough, fever, generalized myalgia, and severe fatigue. The global health authorities must take preventive measures to stop the outbreak of this emerging variant across the globe to minimize the disease burden. | 2023 Oct | European review for medical and pharmacological sciences | No DOI | [
{
"LastName": "Meo",
"FirstName": "S A",
"Affiliation": "Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. [email protected]."
},
{
"LastName": "Meo",
"FirstName": "A S",
"Affiliation": ""
},
{
"LastName": "Klonoff",
"FirstName": "D C",
"Affiliation": ""
}
] | No |
30951700 | The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH). | As the fifth most common cancer and the second leading cause of cancer related deaths worldwide, hepatocellular carcinoma (HCC) causes up to one million deaths annually. Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) are becoming the two major risk factors because both may develop liver fibrosis and hepatocellular carcinoma (HCC) if left untreated. However, compared with 3-10% of patients with ASH may progress to HCC annually, about only 0.5% NASH patients may progress to HCC annually. The present study is to clarify the protein expression differences of tumor suppressor genes (TSGs) between ASH and NASH. In liver biopsied specimens from NASH and ASH patients, using an immunofluorescence method and morphometrically quantitating the fluorescence intensity, we studied the protein expression within hepatocytes cytoplasm of candidate TSGs including RUNX3, GSTP1, and RASSF1A. Compared with the control group of patients, the expression levels of all three proteins were upregulated in the ASH group of patients (p < .001 in all molecules). While RUNX3 was upregulated, GSTP1 and RASSF1 did not change in the NASH group of patients. The most important finding is that compared with the ASH group of patients, the expression levels of all three TSG proteins, RUNX3, GSTP1, and RASSF1, were significantly lower in the NASH group of patients (p < .001 in all three molecules). These results confirmed our previous finding that there are significant differences of many molecules including TSGs that changed in NASH compared to ASH. Thus, we conclude that there are significantly different TSGs and pathways involved during the pathogenesis of HCC development in NASH compared to ASH that may help to develop different strategies for prevention and treatment of NASH and ASH patients. | 2019 Jun | Experimental and molecular pathology | No DOI | [
{
"LastName": "Jia",
"FirstName": "Yue",
"Affiliation": "Harbor-UCLA Medical Center, Department of Pathology, Torrance, CA 90502, United States."
},
{
"LastName": "Ji",
"FirstName": "Ping",
"Affiliation": "Harbor-UCLA Medical Center, Department of Pathology, Torrance, CA 90502, United States."
},
{
"LastName": "French",
"FirstName": "Barbara",
"Affiliation": "Harbor-UCLA Medical Center, Department of Pathology, Torrance, CA 90502, United States."
},
{
"LastName": "Tillman",
"FirstName": "Brittany",
"Affiliation": "Harbor-UCLA Medical Center, Department of Pathology, Torrance, CA 90502, United States."
},
{
"LastName": "French",
"FirstName": "Samuel W",
"Affiliation": "Harbor-UCLA Medical Center, Department of Pathology, Torrance, CA 90502, United States. Electronic address: [email protected]."
}
] | No |
35761975 | Investigation of the Disparities in Ultrasound Imaging Features of miR-323, miR-409-3p, and VEGF Expression Scales in Different Clinicopathological Features of Prostate Carcinoma and Their Correlation with Prognosis. | Prostate carcinoma (PC) is a disease of the male genitourinary system and a relatively common malignant tumor. In order to investigate the disparities in the expression of microRNA-323 (miR-323), microRNA-409-3p (miR-409-3p), and vascular endothelial growth factor (VEGF) in prostate carcinoma with different clinicopathological features and analyze their correlation with prognosis. Thirty-two sufferers with prostate carcinoma and forty-three sufferers with benign prostatic hyperplasia are included. The results show that the detection of miR-323, miR-409-3p, and VEGF scales can provide reference value for clinical guidance of prostate carcinoma prognosis. | 2022 | BioMed research international | No DOI | [
{
"LastName": "Liu",
"FirstName": "Bao",
"Affiliation": "Shanxi Medical University, Taiyuan 030001, China."
},
{
"LastName": "Wang",
"FirstName": "Jingqi",
"Affiliation": "Department of Urology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China."
},
{
"LastName": "Cui",
"FirstName": "Yanhua",
"Affiliation": "Department of Ultrasound, Shanxi Provincial People's Hospital, Taiyuan 030001, China."
},
{
"LastName": "He",
"FirstName": "Hui",
"Affiliation": "Emergency Ultrasound Department of the First Hospital of Shanxi Medical University, Taiyuan 030001, China."
}
] | Yes |
37540573 | Surgical Casualty Care in Contested Distributed Maritime Operations: Lessons Learned From the Falklands War. | The Falklands Campaign was fought a significant distance from the home base of the British Fleet. The planning and delivery of medical care during this campaign can provide significant lessons for strategic medical planning in other far spread geographic locations, including the Indo-Pacific region. Consideration of doctrine, including Role 1-4 facilities and the golden hour, may need to be reconsidered in light of changing scenarios. New concepts such as the "90-in-90" and "3-in-3" are also discussed as a framework for future planning in the U.S. Indo-Pacific Command area of responsibility. | 2024 Jan 23 | Military medicine | No DOI | [
{
"LastName": "Hughey",
"FirstName": "Scott",
"Affiliation": "Department of Anesthesiology and Pain Medicine, Naval Hospital Okinawa, Okinawa 96362, Japan."
},
{
"LastName": "Cole",
"FirstName": "Jacob",
"Affiliation": "Naval Biotechnology Group, Naval Medical Center Portsmouth, Portsmouth, VA 23507, USA."
},
{
"LastName": "Brust",
"FirstName": "Adam",
"Affiliation": "Department of Anesthesiology and Pain Medicine, Naval Hospital Okinawa, Okinawa 96362, Japan."
},
{
"LastName": "Checchi",
"FirstName": "Kyle",
"Affiliation": "III Marine Expeditionary Force, Okinawa 96362, Japan."
},
{
"LastName": "Kotler",
"FirstName": "Joshua",
"Affiliation": "III Marine Expeditionary Force, Okinawa 96362, Japan."
},
{
"LastName": "Lin",
"FirstName": "Andrew",
"Affiliation": "III Marine Expeditionary Force, Okinawa 96362, Japan."
}
] | No |
38588930 | Effect of Reconstituted Human Apolipoprotein A-I on Recurrent Ischemic Events in Survivors of Acute MI. | The AEGIS-II trial hypothesized that CSL112, an intravenous formulation of human apoA-I, would lower the risk of plaque disruption, decreasing the risk of recurrent events such as myocardial infarction (MI) among high-risk patients with MI. This exploratory analysis evaluates the effect of CSL112 therapy on the incidence of cardiovascular (CV) death and recurrent MI. The AEGIS-II trial was an international, multicenter, randomized, double-blind, placebo-controlled trial that randomized 18,219 high-risk acute MI patients to 4 weekly infusions of apoA-I (6 g CSL112) or placebo. The incidence of the composite of CV death and type 1 MI was 11% to 16% lower in the CSL112 group over the study period (HR: 0.84; 95% CI: 0.7-1.0; P = 0.056 at day 90; HR: 0.86; 95% CI: 0.74-0.99; P = 0.048 at day 180; and HR: 0.89; 95% CI: 0.79-1.01; P = 0.07 at day 365). Similarly, the incidence of CV death or any MI was numerically lower in CSL112-treated patients throughout the follow-up period (HR: 0.92; 95% CI: 0.80-1.05 at day 90, HR: 0.89; 95% CI: 0.79-0.996 at day 180, HR: 0.91; 95% CI: 0.83-1.01 at day 365). The effect of CSL112 treatment on MI was predominantly observed for type 1 MI and type 4b (MI due to stent thrombosis). Although CSL112 did not significantly reduce the occurrence of the primary study endpoints, patients treated with CSL112 infusions had numerically lower rates of CV death and MI, type-1 MI, and stent thrombosis-related MI compared with placebo. These findings could suggest a role of apoA-I in reducing subsequent plaque disruption events via enhanced cholesterol efflux. Further prospective data would be needed to confirm these observations. | 2024 Jun 4 | Journal of the American College of Cardiology | No DOI | [
{
"LastName": "Povsic",
"FirstName": "Thomas J",
"Affiliation": "Duke Clinical Research Institute/Duke University Medical Center, Durham, North Carolina, USA."
},
{
"LastName": "Korjian",
"FirstName": "Serge",
"Affiliation": "PERFUSE Study Group, Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."
},
{
"LastName": "Bahit",
"FirstName": "M Cecilia",
"Affiliation": "INECO Neurociencias, Rosario, Argentina."
},
{
"LastName": "Chi",
"FirstName": "Gerald",
"Affiliation": "PERFUSE Study Group, Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."
},
{
"LastName": "Duffy",
"FirstName": "Danielle",
"Affiliation": "CSL Behring, King of Prussia, Pennsylvania, USA."
},
{
"LastName": "Alexander",
"FirstName": "John H",
"Affiliation": "Duke Clinical Research Institute/Duke University Medical Center, Durham, North Carolina, USA."
},
{
"LastName": "Vinereanu",
"FirstName": "Dragos",
"Affiliation": "University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania."
},
{
"LastName": "Tricoci",
"FirstName": "Pierluigi",
"Affiliation": "CSL Behring, King of Prussia, Pennsylvania, USA."
},
{
"LastName": "Mears",
"FirstName": "Sojaita Jenny",
"Affiliation": "CSL Behring, King of Prussia, Pennsylvania, USA."
},
{
"LastName": "Deckelbaum",
"FirstName": "Lawrence I",
"Affiliation": "CSL Behring, King of Prussia, Pennsylvania, USA."
},
{
"LastName": "Bonaca",
"FirstName": "Marc",
"Affiliation": "University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA."
},
{
"LastName": "Ridker",
"FirstName": "Paul M",
"Affiliation": "Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
},
{
"LastName": "Goodman",
"FirstName": "Shaun G",
"Affiliation": "Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada."
},
{
"LastName": "Cornel",
"FirstName": "Jan H",
"Affiliation": "Radboud University Medical Center, Nijmegen and Noordwest Ziekenhuisgroep, Alkmaar, the Netherlands."
},
{
"LastName": "Lewis",
"FirstName": "Basil S",
"Affiliation": "Lady Davis Carmel Medical Center and the Technion-Israel Institute of Technology, Aurora, Colorado, USA."
},
{
"LastName": "Parkhomenko",
"FirstName": "Alexander",
"Affiliation": "National Scientific Center, Kyiv, Ukraine."
},
{
"LastName": "Lopes",
"FirstName": "Renato D",
"Affiliation": "Duke Clinical Research Institute/Duke University Medical Center, Durham, North Carolina, USA."
},
{
"LastName": "Aylward",
"FirstName": "Philip",
"Affiliation": "South Australian Health and Medical Research Institute/SAHMRI, Adelaide, South Australia, Australia."
},
{
"LastName": "Lincoff",
"FirstName": "A Michael",
"Affiliation": "Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio, USA."
},
{
"LastName": "Heise",
"FirstName": "Mark",
"Affiliation": "CSL Behring, King of Prussia, Pennsylvania, USA."
},
{
"LastName": "Sacks",
"FirstName": "Frank",
"Affiliation": "Department of Nutrition, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts, USA."
},
{
"LastName": "Nicolau",
"FirstName": "Jose C",
"Affiliation": "Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil."
},
{
"LastName": "Merkely",
"FirstName": "Bela",
"Affiliation": "Heart and Vascular Center of Semmelweis University, Budapest, Hungary."
},
{
"LastName": "Trebacz",
"FirstName": "Jaroslaw",
"Affiliation": "Krakowski Szpital Specjalistyczny im. Jana Pawła II, Kraków, Poland."
},
{
"LastName": "Libby",
"FirstName": "Peter",
"Affiliation": "Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
},
{
"LastName": "Nicholls",
"FirstName": "Stephen J",
"Affiliation": "Victorian Heart Hospital, Monash Heart and Intensive Care, Clayton, Victoria, Australia."
},
{
"LastName": "Pocock",
"FirstName": "Stuart",
"Affiliation": "London School of Hygiene and Tropical Medicine, London, United Kingdom."
},
{
"LastName": "Bhatt",
"FirstName": "Deepak L",
"Affiliation": "Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA."
},
{
"LastName": "Kastelein",
"FirstName": "John",
"Affiliation": "Academic Medical Centre/University of Amsterdam, Amsterdam, the Netherlands."
},
{
"LastName": "Bode",
"FirstName": "Christoph",
"Affiliation": "University of Freiburg, Freiburg, Germany."
},
{
"LastName": "Mahaffey",
"FirstName": "Kenneth W",
"Affiliation": "Stanford Center for Clinical Research, Stanford University School of Medicine, Stanford, California, USA."
},
{
"LastName": "Steg",
"FirstName": "P Gabriel",
"Affiliation": "Universite Paris-Cité, INSERM 1148, FACT, and AP-HP, Hôpital Bichat, Paris, France."
},
{
"LastName": "Tendera",
"FirstName": "Michal",
"Affiliation": "Department of Cardiology and Structural Heart Disease, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland."
},
{
"LastName": "Bainey",
"FirstName": "Kevin R",
"Affiliation": "Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada."
},
{
"LastName": "Harrington",
"FirstName": "Robert A",
"Affiliation": "Weill Cornell Medicine, New York, New York, USA."
},
{
"LastName": "Mehran",
"FirstName": "Roxana",
"Affiliation": "University of Freiburg, Freiburg, Germany."
},
{
"LastName": "Duerschmied",
"FirstName": "Daniel",
"Affiliation": "Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany."
},
{
"LastName": "Kingwell",
"FirstName": "Bronwyn A",
"Affiliation": "CSL Limited, Melbourne, Victoria, Australia."
},
{
"LastName": "Gibson",
"FirstName": "C Michael",
"Affiliation": "PERFUSE Study Group, Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: [email protected]."
}
] | No |
38264479 | Vertical transfer and functional characterization of cotton seed core microbiome. | Microbiome within plant tissues is pivotal for co-evolution with host plants. This microbiome can colonize the plant, with potential transmission via seeds between parents and offspring, affecting seedling growth and host plant adaptability to the environment. We employed 16S rRNA gene amplicon analysis to investigate the vertical distribution of core microbiome in cotton seeds across ecological niches [rhizosphere, root, stem, leaf, seed and seed-P (parental seed)] of the three cotton genotypes. The findings demonstrated a significant decrease in microbiome diversity and network complexity from roots, stems, and leaves to seeds. The microenvironment exerted a more substantial influence on the microbiome structure of cotton than the genotypes. The core endophytic microorganisms in cotton seeds comprised 29 amplicon sequence variants (ASVs) affiliated with Acidimicrobiia, Alphaproteobacteria, Bacilli, Bacteroidia, Clostridia, Gammaproteobacteria, and unclassified_Proteobacteria. These vertically transmitted taxa are widely distributed in cotton plants. Through 16S rRNA gene-based function prediction analysis of the cotton microbiome, we preliminarily understood that there are potential differences in metabolic capabilities and phenotypic traits among microbiomes in different microhabitats. In conclusion, this study demonstrated the crucial role of the microenvironment in influencing the cotton microbiome and offered insights into the structures and functions of the cotton seed microbiome, facilitating future crop yield enhancement through core seed microbiome regulation. | 2023 | Frontiers in microbiology | No DOI | [
{
"LastName": "Wu",
"FirstName": "Chongdie",
"Affiliation": "College of Life Sciences, Shihezi University, Shihezi, China."
},
{
"LastName": "Zhang",
"FirstName": "Xin",
"Affiliation": "College of Life Sciences, Shihezi University, Shihezi, China."
},
{
"LastName": "Fan",
"FirstName": "Yongbin",
"Affiliation": "College of Life Sciences, Shihezi University, Shihezi, China."
},
{
"LastName": "Ye",
"FirstName": "Jingyi",
"Affiliation": "College of Life Sciences, Shihezi University, Shihezi, China."
},
{
"LastName": "Dong",
"FirstName": "Lingjun",
"Affiliation": "College of Life Sciences, Shihezi University, Shihezi, China."
},
{
"LastName": "Wang",
"FirstName": "YuXiang",
"Affiliation": "College of Life Sciences, Shihezi University, Shihezi, China."
},
{
"LastName": "Ren",
"FirstName": "YinZheng",
"Affiliation": "College of Life Sciences, Shihezi University, Shihezi, China."
},
{
"LastName": "Yong",
"FirstName": "HongHong",
"Affiliation": "College of Life Sciences, Shihezi University, Shihezi, China."
},
{
"LastName": "Liu",
"FirstName": "Ruina",
"Affiliation": "College of Life Sciences, Shihezi University, Shihezi, China."
},
{
"LastName": "Wang",
"FirstName": "Aiying",
"Affiliation": "College of Life Sciences, Shihezi University, Shihezi, China."
}
] | No |
31691575 | Anaerobic Transcription by OxyR: A Novel Paradigm for Nitrosative Stress. | Significance: S-nitrosylation, the post-translational modification by nitric oxide (NO) to form S-nitrosothiols (SNOs), regulates diverse aspects of cellular function, and aberrant S-nitrosylation (nitrosative stress) is implicated in disease, from neurodegeneration to cancer. Essential roles for S-nitrosylation have been demonstrated in microbes, plants, and animals; notably, bacteria have often served as model systems for elucidation of general principles. Recent Advances: Recent conceptual advances include the idea of a molecular code through which proteins sense and differentiate S-nitrosothiol (SNO) from alternative oxidative modifications, providing the basis for specificity in SNO signaling. In Escherichia coli, S-nitrosylation relies on an enzymatic cascade that regulates, and is regulated by, the transcription factor OxyR under anaerobic conditions. S-nitrosylated OxyR activates an anaerobic regulon of >100 genes that encode for enzymes that both mediate S-nitrosylation and protect against nitrosative stress. Critical Issues: Mitochondria originated from endosymbiotic bacteria and generate NO under hypoxic conditions, analogous to conditions in E. coli. Nitrosative stress in mitochondria has been implicated in Alzheimer's and Parkinson's disease, among others. Many proteins that are S-nitrosylated in mitochondria are also S-nitrosylated in E. coli. Insights into enzymatic regulation of S-nitrosylation in E. coli may inform the identification of disease-relevant regulatory machinery in mammalian systems. Future Directions: Using E. coli as a model system, in-depth analysis of the anaerobic response controlled by OxyR may lead to the identification of enzymatic mechanisms regulating S-nitrosylation in particular, and hypoxic signaling more generally, providing novel insights into analogous mechanisms in mammalian cells and within dysfunctional mitochondria that characterize neurodegenerative diseases. | 2020 Apr 20 | Antioxidants & redox signaling | No DOI | [
{
"LastName": "Seth",
"FirstName": "Divya",
"Affiliation": "Institute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, Ohio."
},
{
"LastName": "Hausladen",
"FirstName": "Alfred",
"Affiliation": "Institute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, Ohio."
},
{
"LastName": "Stamler",
"FirstName": "Jonathan S",
"Affiliation": "Institute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, Ohio."
}
] | No |
26843993 | Autoextraction of Permanent Incisors and Self-Inflicted Orodental Trauma in a Severely Burned Child. | Autoextraction is one type of self-injurious behaviour. In the literature, self-injurious behaviours are observed in syndromes and genetic conditions. However, to the best of our knowledge, SIB and autoextraction in a severely burned patient have not been reported to date. This report describes the self-inflicted trauma and autoextraction in a severely burned child, and the management of the child during and after burn treatment. | 2015 | Case reports in dentistry | No DOI | [
{
"LastName": "Keles",
"FirstName": "Sultan",
"Affiliation": "Department of Paediatric Dentistry, Faculty of Dentistry, Adnan Menderes University, 09100 Aydın, Turkey."
},
{
"LastName": "Dogusal",
"FirstName": "Gülçin",
"Affiliation": "Department of Paediatric Dentistry, Faculty of Dentistry, Adnan Menderes University, 09100 Aydın, Turkey."
},
{
"LastName": "Sönmez",
"FirstName": "Işıl",
"Affiliation": "Department of Paediatric Dentistry, Faculty of Dentistry, Adnan Menderes University, 09100 Aydın, Turkey."
}
] | No |
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