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38183522 | Mycobacterium marinum mediates regulation of prostaglandin E(2) expression on host immune response through cyclooxygenase pathway. | Investigate the role of COX signaling in activating the PGE2-EP2 pathway. Utilized a marine Mycobacterium infection model in zebrafish. Marine mycobacteria were stained with fluorescein isothiocyanate. The COX inhibitor indomethacin, EP2 receptor inhibitor AH6809, EP4 receptor inhibitor AH23848 and clodronate Liposomes were used to investigate the role of COX, EP2, EP4 and macrophage whether participating in combat marine mycobacterial infection. The expression level of the target gene was detected using real-time fluorescence quantitative PCR instrument. The findings revealed that larvae exposed to the COX inhibitor indomethacin or the EP2 receptor inhibitor AH6809 demonstrated a significantly higher mortality rate due to marine mycobacterium infection than those in the control group. Administration of exogenous prostaglandin E2 (PGE2) rescued the survival of zebrafish infected with marine mycobacteria and treated with indomethacin. Additionally, a significant reduction in survival rate was noted in macrophage-depleted zebrafish infected with marine mycobacteria. The host may combat marine mycobacterium infection via COX signaling, which activates the PGE2-EP2 pathway and mediates macrophage resistance. | 2024 Jan 6 | Molecular biology reports | No DOI | [
{
"LastName": "Lin",
"FirstName": "Dongzi",
"Affiliation": "Department of Laboratory Medicine, The Fourth People's Hospital of Nanhai District of Foshan City, 528000, Foshan, Guangdong, China."
},
{
"LastName": "Lin",
"FirstName": "Bingyao",
"Affiliation": "Department of Laboratory Medicine, Foshan Fourth People's Hospital, 528041, Foshan, Guangdong, China."
},
{
"LastName": "Wang",
"FirstName": "Xuezhi",
"Affiliation": "Department of Laboratory Medicine, Foshan Fourth People's Hospital, 528041, Foshan, Guangdong, China."
},
{
"LastName": "Xu",
"FirstName": "Cheng",
"Affiliation": "Department of Laboratory Medicine, The Fourth People's Hospital of Nanhai District of Foshan City, 528000, Foshan, Guangdong, China."
},
{
"LastName": "Mo",
"FirstName": "Liyi",
"Affiliation": "Department of Laboratory Medicine, The Fourth People's Hospital of Nanhai District of Foshan City, 528000, Foshan, Guangdong, China."
},
{
"LastName": "Luo",
"FirstName": "Yanwen",
"Affiliation": "Department of Laboratory Medicine, The Fourth People's Hospital of Nanhai District of Foshan City, 528000, Foshan, Guangdong, China."
},
{
"LastName": "Tian",
"FirstName": "Honghong",
"Affiliation": "Department of Laboratory Medicine, Foshan Fourth People's Hospital, 528041, Foshan, Guangdong, China."
},
{
"LastName": "Zhou",
"FirstName": "Lei",
"Affiliation": "Institute of Green Chemistry and Molecular Engineering, School of Chemistry, Sun Yat-sen University, 510275, Guangzhou, China. [email protected]."
},
{
"LastName": "Chen",
"FirstName": "Zhenhua",
"Affiliation": "Department of Laboratory Medicine, The Fourth People's Hospital of Nanhai District of Foshan City, 528000, Foshan, Guangdong, China. [email protected]."
}
] | No |
36342849 | Genome-wide DNA methylation profiling of gastric cardia cancer. | Aberrant DNA methylation has been found in various cancer types including gastric cancer, yet the genome-wide DNA methylation profile of gastric cardia cancer (GCC) remains unclear. Therefore, we aimed to profile the DNA methylation pattern of GCC and identify promising diagnostic epigenetic biomarkers. We investigated the genome-wide DNA methylation pattern in eight pairs of GCC and adjacent normal tissues using Illumina 850K microarrays. Subsequently, bisulfite-pyrosequencing and quantitative real-time PCR were performed on eight pairs of GCC-adjacent normal tissues for validation. Finally, we performed immunohistochemistry to examine ADHFE1 expression on 126 pairs of GCC-adjacent normal samples. DNA methylome analysis showed global hypomethylation and local hypermethylation of promoter cytosine-phosphate-guanine (CpG) islands (CGIs) in GCC tissues compared with gastric cardia normal mucosa (P < 2.2 × 10[-16]). Differential methylation analysis identified a total of 91 723 differentially-methylated probes (DMPs), and the candidate gene with the largest average DNA methylation difference mapped to ADHFE1 (mean Δβ = 0.53). Subsequently, three DMPs in the ADHFE1 promoter were validated by pyrosequencing. Notably, the mean methylation level of the three candidate DMPs (ADHFE1_cg08090772, ADHFE1_cg19283840, and ADHFE1_cg20295442) was negatively associated with ADHFE1 mRNA expression level (Spearman rho = -0.64, P = 0.01). Moreover, both mRNA (P = 0.0213) and protein (P < 0.0001) expression of ADHFE1 were significantly decreased in GCCs compared with the adjacent normal tissues. Our results reveal DNA methylation aberrations in GCC and that ADHFE1 gene DNA methylation contributes to the risk of GCC, thus providing novel mechanistic insights into gastric cardia cancer carcinogenesis. | 2023 Feb | Journal of gastroenterology and hepatology | No DOI | [
{
"LastName": "Lin",
"FirstName": "Runhua",
"Affiliation": "Department of Pathology, Shantou University Medical College, Shantou, China."
},
{
"LastName": "Qian",
"FirstName": "Yanli",
"Affiliation": "Department of Pathology, Shantou University Medical College, Shantou, China."
},
{
"LastName": "Zhang",
"FirstName": "Jinhai",
"Affiliation": "Department of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China."
},
{
"LastName": "Xia",
"FirstName": "Di",
"Affiliation": "Department of Pathology, Shantou University Medical College, Shantou, China."
},
{
"LastName": "Guo",
"FirstName": "Dongming",
"Affiliation": "Department of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China."
},
{
"LastName": "Hong",
"FirstName": "Liangli",
"Affiliation": "Department of Pathology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China."
},
{
"LastName": "Qing",
"FirstName": "Bojuan",
"Affiliation": "Department of Pathology, Shantou University Medical College, Shantou, China."
},
{
"LastName": "Xu",
"FirstName": "Muming",
"Affiliation": "Department of Abdominal Surgery, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, China."
},
{
"LastName": "Huang",
"FirstName": "Yiteng",
"Affiliation": "Health Care Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, China."
},
{
"LastName": "Lin",
"FirstName": "Wenting",
"Affiliation": "Department of Pathology, Shantou University Medical College, Shantou, China."
},
{
"LastName": "Chen",
"FirstName": "Guangcan",
"Affiliation": "Department of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China."
},
{
"LastName": "Liu",
"FirstName": "Shuhui",
"Affiliation": "Department of Pathology, Shantou University Medical College, Shantou, China."
}
] | No |
38523867 | The generalized sigmoidal quantile function. | In this note we introduce a new smooth nonparametric quantile function estimator based on a newly defined generalized expectile function and termed the sigmoidal quantile function estimator. We also introduce a hybrid quantile function estimator, which combines the optimal properties of the classic kernel quantile function estimator with our new generalized sigmoidal quantile function estimator. The generalized sigmoidal quantile function can estimate quantiles beyond the range of the data, which is important for certain applications given smaller sample sizes. This property of extrapolation is illustrated in order to improve standard bootstrap smoothing resampling methods. | 2024 | Communications in statistics: Simulation and computation | No DOI | [
{
"LastName": "Hutson",
"FirstName": "Alan D",
"Affiliation": "Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA."
}
] | No |
36739885 | SPINDLY mediates O-fucosylation of hundreds of proteins and sugar-dependent growth in Arabidopsis. | The recent discovery of SPINDLY (SPY)-catalyzed protein O-fucosylation revealed a novel mechanism for regulating nucleocytoplasmic protein functions in plants. Genetic evidence indicates the important roles of SPY in diverse developmental and physiological processes. However, the upstream signal controlling SPY activity and the downstream substrate proteins O-fucosylated by SPY remain largely unknown. Here, we demonstrated that SPY mediates sugar-dependent growth in Arabidopsis (Arabidopsis thaliana). We further identified hundreds of O-fucosylated proteins using lectin affinity chromatography followed by mass spectrometry. All the O-fucosylation events quantified in our proteomic analyses were undetectable or dramatically decreased in the spy mutants, and thus likely catalyzed by SPY. The O-fucosylome includes mostly nuclear and cytosolic proteins. Many O-fucosylated proteins function in essential cellular processes, phytohormone signaling, and developmental programs, consistent with the genetic functions of SPY. The O-fucosylome also includes many proteins modified by O-linked N-acetylglucosamine (O-GlcNAc) and by phosphorylation downstream of the target of rapamycin (TOR) kinase, revealing the convergence of these nutrient signaling pathways on key regulatory functions such as post-transcriptional/translational regulation and phytohormone responses. Our study identified numerous targets of SPY/O-fucosylation and potential nodes of crosstalk among sugar/nutrient signaling pathways, enabling future dissection of the signaling network that mediates sugar regulation of plant growth and development. | 2023 Apr 20 | The Plant cell | No DOI | [
{
"LastName": "Bi",
"FirstName": "Yang",
"Affiliation": "Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA."
},
{
"LastName": "Shrestha",
"FirstName": "Ruben",
"Affiliation": "Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA."
},
{
"LastName": "Zhang",
"FirstName": "Zhenzhen",
"Affiliation": "Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA."
},
{
"LastName": "Hsu",
"FirstName": "Chuan-Chih",
"Affiliation": "Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA."
},
{
"LastName": "Reyes",
"FirstName": "Andres V",
"Affiliation": "Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA."
},
{
"LastName": "Karunadasa",
"FirstName": "Sumudu",
"Affiliation": "Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA."
},
{
"LastName": "Baker",
"FirstName": "Peter R",
"Affiliation": "Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94143, USA."
},
{
"LastName": "Maynard",
"FirstName": "Jason C",
"Affiliation": "Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94143, USA."
},
{
"LastName": "Liu",
"FirstName": "Yang",
"Affiliation": "ThermoFisher Scientific, San Jose, California 95134, USA."
},
{
"LastName": "Hakimi",
"FirstName": "Amirmansoor",
"Affiliation": "ThermoFisher Scientific, San Jose, California 95134, USA."
},
{
"LastName": "Lopez-Ferrer",
"FirstName": "Daniel",
"Affiliation": "ThermoFisher Scientific, San Jose, California 95134, USA."
},
{
"LastName": "Hassan",
"FirstName": "Tahmid",
"Affiliation": "ThermoFisher Scientific, Somerset, New Jersey 08873, USA."
},
{
"LastName": "Chalkley",
"FirstName": "Robert J",
"Affiliation": "Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94143, USA."
},
{
"LastName": "Xu",
"FirstName": "Shou-Ling",
"Affiliation": "Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA."
},
{
"LastName": "Wang",
"FirstName": "Zhi-Yong",
"Affiliation": "Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA."
}
] | No |
32352595 | Low androgen status inhibits erectile function by up-regulating the expression of P2X receptors in rat corpus cavernosum. | The aim of our study was to investigate whether low androgen level inhibits the erectile function of rats by regulating the expression of P2X receptors. Thirty-six 8-week-old male SD rats were randomly divided into six groups: sham-operated groups (4w-sham, 8w-sham), castration groups (4w-cast, 8w-cast) and androgen replacement after castration groups (4w-cast + T, 8w-cast + T). The maximum intracavernous pressure/mean arterial pressure (ICPmax/MAP), the levels of serum testosterone (T) and nitric oxide (NO), and the expression of P2X1, P2X2, P2X3, eNOS, p-eNOS, ROCK1 and ROCK2 in the cavernous tissue of rats were determined. The serum T, ICPmax/MAP and NO levels in penile corpus cavernosum in the castration groups were significantly lower than those in other groups (p < .01). The protein expression of P2X1, P2X2, P2X3, ROCK1 and ROCK2 in the castration groups was significantly higher than those in other groups (p < .01). P-eNOS/eNOS of the castration groups were significantly lower than those of other groups (p < .01). The serum T level was negatively correlated with the expression of P2X1, P2X2 and P2X3 in the corpus cavernosum. Low androgen level inhibits erectile function by up-regulating the expression of P2X1, P2X2, P2X3 and RhoA/Rho-kinase resulting in reducing the ratio of p-eNOS/eNOS and the level of NO in corpus cavernosum of rats. | 2020 Aug | Andrologia | No DOI | [
{
"LastName": "Guo",
"FirstName": "Chuan",
"Affiliation": "Department of Urology, The Affiliated Hospital of Southwest Medical University, Luzhou, China."
},
{
"LastName": "Jiang",
"FirstName": "Jun",
"Affiliation": "Department of Thyroid Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China."
},
{
"LastName": "Cheng",
"FirstName": "Bo",
"Affiliation": "Department of Urology, The Affiliated Hospital of Southwest Medical University, Luzhou, China."
},
{
"LastName": "Xie",
"FirstName": "Libo",
"Affiliation": "Department of Urology, The Affiliated Hospital of Southwest Medical University, Luzhou, China."
},
{
"LastName": "Lin",
"FirstName": "Haocheng",
"Affiliation": "Department of Urology, Peking University Third Hospital, Beijing, China."
},
{
"LastName": "Jiang",
"FirstName": "Rui",
"Affiliation": "Department of Urology, The Affiliated Hospital of Southwest Medical University, Luzhou, China."
}
] | No |
22233315 | [Cardiovascular biomarkers in clinical practice of sleep apnea]. | Obstructive sleep apnea syndrome (OSAS) leads to cardiovascular complications such as coronary artery disease, left/right ventricular hypertrophy and dysfunction, heart failure, systemic and pulmonary hypertension, arrhythmias and stroke; and these all cardiovascular complications increase morbidity and mortality of OSAS. However, Cheyne-Stokes respiration, central and obstructive apneas may occur in the patient with heart failure. Increased sympathetic activity by hypoxemia and endothelial dysfunction play a role in cardiovascular complications. Some cardiovascular biomarkers have a role in early diagnosis, treatment and prognosis. In the present review, some cardiovascular biomarkers such as serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukins, adiponectin, heart-type fatty acid binding protein (hFABP) and brain (B-type) natriuretic peptide (BNP), and their clinical importance were reviewed. | 2011 | Tuberkuloz ve toraks | No DOI | [
{
"LastName": "Dursunoğlu",
"FirstName": "Dursun",
"Affiliation": "Department of Cardiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey. [email protected]"
},
{
"LastName": "Dursunoğlu",
"FirstName": "Neşe",
"Affiliation": ""
}
] | No |
39036680 | Is tattooing associated with increased seroprevalence of transfusion-transmitted infections among blood donors: A single-center study from Southeastern India. | The regulations in India mandate a blanket deferral period of 12 months for donors from the time of acquiring a tattoo. The rationale is that using nonsterile needles, the same dyes for many persons, and other unhygienic practices result in the transmission of blood-borne infections. However, currently, autoclavable tattoo equipment, professional tattoo gun, single-use dye, and needle for tattooing have come up and are known to be devoid of the risks mentioned above. Hence, this study was designed to assess if the seroprevalence of transfusion-transmitted infections (TTIs) among tattooed blood donors was higher than in other nontattooed donors. This cross-sectional comparative study was conducted in the Department of Transfusion Medicine at the tertiary care teaching hospital in Pondicherry from September 2017 to May 2019. The study group included blood donors in the age group of 18-60 years with one or more tattoos, and the control group was chosen among blood donors of the same age without a tattoo. The sampling technique was consecutive. The serological prevalence of the two groups was compared for HIV, hepatitis B virus, hepatitis C virus, Syphilis, and Malaria. A total of 368 donors were recruited for the study, 184 donors with tattoos and 184 donors without a tattoo. The detected seroprevalence of TTI among the tattooed and nontattooed groups was 3.8% and 4.3%, respectively. There was no significant association found between tattooing and seroprevalence of TTI. About 60% of the ones who got a tattoo had obtained it from a licensed tattoo parlor. We found that the seroprevalence of TTI among tattooed donors was similar to that of nontattooed donors. However, the seroprevalence among donors who had undergone more than one tattooing experience was higher than those who had a single tattooing event. | 2024 Jan-Jun | Asian journal of transfusion science | No DOI | [
{
"LastName": "Arjunan",
"FirstName": "Charumathy",
"Affiliation": "Department of Transfusion Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India."
},
{
"LastName": "Basavarajegowda",
"FirstName": "Abhishekh",
"Affiliation": "Department of Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India."
}
] | No |
26885007 | Pathological observation of acute myocardial infarction in Chinese miniswine. | The acute myocardial infarction (AMI) model in Chinese miniswine was built by percutaneous coronary artery occlusion. Pathological observation of AMI was performed, and the expression of tumor necrosis factor alpha (TNF-α) in the infarct sites was detected at different days after modeling in Chinese miniswine. The experimental findings may be used as the basis for blood flow reconstruction and intervention after AMI. Seven experimental Chinese miniswine were subjected to general anesthesia and Seldinger right femoral artery puncture. After coronary angiography, the gelfoam was injected via the microtube to occlude the obtuse marginal branch (OM branch). At 1 d, 3 d, 5 d, 7 d, 10 d, 14 d and 17 d after modeling, hetatoxylin-eosin (HE) staining was performed to observe the pathological changes and to detect the expression of TNF-α in the myocardial tissues. Cytoplasmic acidophilia of the necrotic myocardial tissues at 1 d after modeling was enhanced, and cytoplasmic granules were formed; at 3 d, the margins of the necrotic myocardial tissues were infiltrated by a large number of inflammatory cells; at 5 d, the nuclei of the necrotic myocardial cells were fragmented; at 7 d, extensive granulation tissues were formed at the margin of the necrotic myocardial tissues; at 10 d, part of the granulation tissues were replaced by fibrous scar tissues; at 14-17 d, all granulation tissues were replaced by fibrous scar tissues. Immunohistochemical detection indicated that no TNF-α expression in normal myocardial tissues. The TNF-α expression was first detected at 3 d in the necrotic myocardial tissues and then increased at 5 d and 7 d. After reaching the peak at 10 d, the expression began to decrease at 14 d and the decrease continued at 17 d. Coronary angiography showed the disappearance of blood flow at the distal end of OM branch occluded by gelfoam, indicating that AMI model was constructed successfully. The repair of the infarcted myocardium began at 10-17 d after modeling with safe blood flow reconstruction. TNF-α expression in the infarcted myocardium was the highest at 10 d, which can be explained by inflammation and repair of the infarcted myocardium. | 2015 | International journal of clinical and experimental medicine | No DOI | [
{
"LastName": "Wang",
"FirstName": "Chuang",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
},
{
"LastName": "Wang",
"FirstName": "Shao-Xin",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
},
{
"LastName": "Dong",
"FirstName": "Ping-Shuan",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
},
{
"LastName": "Wang",
"FirstName": "Li-Ping",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
},
{
"LastName": "Duan",
"FirstName": "Na-Na",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
},
{
"LastName": "Wang",
"FirstName": "Yan-Yu",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
},
{
"LastName": "Wang",
"FirstName": "Ke",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
},
{
"LastName": "Li",
"FirstName": "Zhuan-Zhen",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
},
{
"LastName": "Wei",
"FirstName": "Li-Juan",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
},
{
"LastName": "Meng",
"FirstName": "Ya-Li",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
},
{
"LastName": "Cheng",
"FirstName": "Jian-Xin",
"Affiliation": "Department of Cardiology, The First Affiliated Hospital, Henan University of Science and Technology Jinghua Road No. 24, Luoyang 471003, China."
}
] | No |
18281291 | Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. | Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death. | 2008 Apr 18 | The Journal of biological chemistry | No DOI | [
{
"LastName": "Zhang",
"FirstName": "Huafeng",
"Affiliation": "Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA."
},
{
"LastName": "Bosch-Marce",
"FirstName": "Marta",
"Affiliation": ""
},
{
"LastName": "Shimoda",
"FirstName": "Larissa A",
"Affiliation": ""
},
{
"LastName": "Tan",
"FirstName": "Yee Sun",
"Affiliation": ""
},
{
"LastName": "Baek",
"FirstName": "Jin Hyen",
"Affiliation": ""
},
{
"LastName": "Wesley",
"FirstName": "Jacob B",
"Affiliation": ""
},
{
"LastName": "Gonzalez",
"FirstName": "Frank J",
"Affiliation": ""
},
{
"LastName": "Semenza",
"FirstName": "Gregg L",
"Affiliation": ""
}
] | Yes |
35432630 | m(6)A-Related lncRNAs Are Potential Prognostic Biomarkers of Cervical Cancer and Affect Immune Infiltration. | The correlation of m[6]A-related lncRNAs with the prognosis and immune microenvironment of cervical cancer is not yet clear. In this study, we identified 7 m[6]A-related prognostic lncRNAs by Pearson correlation and univariate Cox regression analyses based on TCGA-cervical cancer dataset. Then, patients were divided into two clusters by consensus clustering based on the 7 m[6]A-related prognostic lncRNA expression. Cluster 1 was characterized by survival and stage disadvantage, enrichment of immunosuppressive and carcinogenic activation pathways. Besides, cluster 1 had higher immunosuppressive factor TGFbeta and lower immune cell infiltration compared with cluster 2. According to the expression of 7 m[6]A-related lncRNA, a 6-m[6]A-related lncRNA risk score model was established in the training set by LASSO regression analysis. The high-risk group had worse overall survival than the low-risk group. No matter in the training or validation sets, the m[6]A-related lncRNA risk score was an independent prognostic factor for overall survival. Meanwhile, we validated the independent prognostic value of risk score in the disease-specific survival and progression-free survival by multivariate Cox analysis. The high-risk group was characterized by higher TGFbeta and regulatory T cell and was rich in malignant pathways. Additionally, we also detected and compared the expression levels of four m[6]A-related prognostic lncRNA in 9 tumor samples and 9 normal tissues using quantitative real-time polymerase chain reaction assay. In conclusion, the novel m[6]A-related lncRNA risk score is a potential prognostic predictor of cervical cancer patients. These 6 m[6]A-related lncRNAs might serve as key mediators of the immune microenvironment and represent promising therapeutic targets for improving cervical cancer prognosis. | 2022 | Disease markers | No DOI | [
{
"LastName": "Jia",
"FirstName": "Haixia",
"Affiliation": "Department of Prevention Care, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China."
},
{
"LastName": "Hao",
"FirstName": "Suhua",
"Affiliation": "Department of Prevention Care, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China."
},
{
"LastName": "Cao",
"FirstName": "Meiting",
"Affiliation": "Department of Gynecology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China."
},
{
"LastName": "Wang",
"FirstName": "Lifang",
"Affiliation": "Department of Geratology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China."
},
{
"LastName": "Bai",
"FirstName": "Hua",
"Affiliation": "Department of Gynecology and Obstetrics, Shanxi Bethune Hospital/Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital/Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China."
},
{
"LastName": "Shui",
"FirstName": "Wen",
"Affiliation": "Department of ECG, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China."
},
{
"LastName": "Yang",
"FirstName": "Xiaotang",
"Affiliation": "Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China."
}
] | No |
35178023 | Update on the Pathogenesis, Clinical Diagnosis, and Treatment of Hirayama Disease. | Hirayama disease (HD) is characterized by the juvenile onset of unilateral or asymmetric weakness and amyotrophy of the hand and ulnar forearm and is most common in males in Asia. A perception of compliance with previous standards of diagnosis and treatment appears to be challenged, so the review is to update on HD. First, based on existing theory, the factors related to HD includes, (1) cervical cord compression during cervical flexion, (2) immunological factors, and (3) other musculoskeletal dynamic factors. Then, we review the clinical manifestations: typically, (1) distal weakness and wasting in one or both upper extremities, (2) insidious onset and initial progression for 3-5 years, (3) coarse tremors in the fingers, (4) cold paralysis, and (5) absence of objective sensory loss; and atypically, (1) positive pyramidal signs, (2) atrophy of the muscles of the proximal upper extremity, (3) long progression, and (4) sensory deficits. Next, updated manifestations of imaging are reviewed, (1) asymmetric spinal cord flattening, and localized lower cervical spinal cord atrophy, (2) loss of attachment between the posterior dural sac and the subjacent lamina, (3) forward displacement of the posterior wall of the cervical dural sac, (4) intramedullary high signal intensity in the anterior horn cells on T2-weighted imaging, and (5) straight alignment or kyphosis of cervical spine. Thus, the main manifestations of eletrophysiological examinations in HD include segmental neurogenic damages of anterior horn cells or anterior roots of the spinal nerve located in the lower cervical spinal cord, without disorder of the sensory nerves. In addition, definite HD needs three-dimensional diagnostic framework above, while probable HD needs to exclude other diseases via "clinical manifestations" and "electrophysiological examinations". Finally, the main purpose of treatment is to avoid neck flexion. Cervical collar is the first-line treatment for HD, while several surgical methods are available and have achieved satisfactory results. This review aimed to improve the awareness of HD in clinicians to enable early diagnosis and treatment, which will enable patients to achieve a better prognosis. | 2021 | Frontiers in neurology | No DOI | [
{
"LastName": "Wang",
"FirstName": "Hongwei",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Tian",
"FirstName": "Ye",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Wu",
"FirstName": "Jianwei",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Luo",
"FirstName": "Sushan",
"Affiliation": "Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Zheng",
"FirstName": "Chaojun",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Sun",
"FirstName": "Chi",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Nie",
"FirstName": "Cong",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Xia",
"FirstName": "Xinlei",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Ma",
"FirstName": "Xiaosheng",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Lyu",
"FirstName": "Feizhou",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Jiang",
"FirstName": "Jianyuan",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
},
{
"LastName": "Wang",
"FirstName": "Hongli",
"Affiliation": "Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China."
}
] | No |
38615507 | POU2F3-positive small cell carcinoma of the bladder: A clinicopathologic analysis of 4 cases and literature review. | POU class 2 homeobox 3 (POU2F3)-positive small cell bladder carcinoma (SCBC) is an extremely rare entity, and its clinicopathologic features have not been fully described. Here, we investigated the clinicopathologic features of 4 cases of POU2F3-positive small cell bladder carcinoma (SCBC) and reviewed the literature. We collected 12 cases of SCBC from our departmental archives and detected the expression of POU2F3 by immunohistochemical (IHC) staining. Selected cases with or without POU2F3 expression were subjected to gene expression analysis between two different groups using DESeq2 software. We identified 4 POU2F3-positive SCBC patients, 2 males and 2 females, with a mean age of 77 years. Three patients had hematuria, and 1 patient had dysuria. Radiologic findings showed a bladder mass. Pathologic diagnosis showed that 3 cases were pure SCBC and 1 was mixed urothelial cancer (UC). Histopathologically, four POU2F3-positive SCBC tumors were composed of small round cells with sparse cytoplasm, the nuclei were salt-and-pepper-like or finely granular. Tumor cells showed characteristic cytoplasmic staining with punctate positive signals for cytokeratin. Syn and CD56 were diffusely positive in all the 4 patients. CgA was positive in only one patient. POU2F3-positive SCBC showed higher expression levels of POU2F3, HMGA2 and PLCG2 genes by RNA-Seq. Our data showed the specific clinicopathologic features of 4 rare POU2F3-positive SCBC cases, and the distinct molecular feature was observed between POU2F3-positive and negative SCBC in the limited number of cases. | 2024 May | Pathology, research and practice | No DOI | [
{
"LastName": "Cai",
"FirstName": "Zhe",
"Affiliation": "Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China."
},
{
"LastName": "Cheng",
"FirstName": "Xiuzhi",
"Affiliation": "Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China."
},
{
"LastName": "Liao",
"FirstName": "Shousheng",
"Affiliation": "Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China."
},
{
"LastName": "Zou",
"FirstName": "Wanwan",
"Affiliation": "Department of Pathology, Jiangxi Cancer Hospital, Nanchang, Jiangxi, China."
},
{
"LastName": "Li",
"FirstName": "Lixiang",
"Affiliation": "Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China."
},
{
"LastName": "Liu",
"FirstName": "Fanrong",
"Affiliation": "Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China."
},
{
"LastName": "Huang",
"FirstName": "Wenyong",
"Affiliation": "Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. Electronic address: [email protected]."
}
] | No |
19376776 | Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. | Notch signaling plays a critical role in regulating cell proliferation, differentiation, and apoptosis. Our previous study showed that overexpression of Notch1 could inhibit human hepatocellular carcinoma (HCC) cell growth by arresting the cell cycle and inducing apoptosis. HCC cells are resistant to apoptotic induction by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), so new therapeutic approaches have been explored to sensitize HCC cells to TRAIL-induced apoptosis. We are wondering whether and how Notch1 signaling can enhance the sensitivity of HCC cells to TRAIL-induced apoptosis. In this study, we found that overexpression of ICN, the constitutive activated form of Notch1, up-regulated p53 protein expression in HCC cells by inhibiting proteasome degradation. p53 up-regulation was further observed in human primary hepatocellular carcinoma cells after activation of Notch signaling. Inhibition of the Akt/Hdm2 pathway by Notch1 signaling was responsible for the suppression of p53 proteasomal degradation, thus contributing to the Notch1 signaling-mediated up-regulation of p53 expression. Accordingly, Notch1 signaling could make HCC cells more sensitive to TRAIL-induced apoptosis, whereas Notch1 signaling lost the synergistic promotion of TRAIL-induced apoptosis in p53-silenced HepG2 HCC cells and p53-defective Hep3B HCC cells. The data suggest that enhancement of TRAIL-induced apoptosis by Notch1 signaling is dependent upon p53 up-regulation. Furthermore, Notch1 signaling could enhance DR5 expression in a p53-dependent manner. Taken together, Notch1 signaling sensitizes TRAIL-induced apoptosis in HCC cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. Thus, our results suggest that activation of Notch1 signaling may be a promising approach to improve the therapeutic efficacy of TRAIL-resistant HCC. | 2009 Jun 12 | The Journal of biological chemistry | No DOI | [
{
"LastName": "Wang",
"FirstName": "Chunmei",
"Affiliation": "From the National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China."
},
{
"LastName": "Qi",
"FirstName": "Runzi",
"Affiliation": "From the National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China."
},
{
"LastName": "Li",
"FirstName": "Nan",
"Affiliation": "From the National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China."
},
{
"LastName": "Wang",
"FirstName": "Zhengxin",
"Affiliation": "Department of Surgery, Changzheng Hospital, Shanghai 200003, China."
},
{
"LastName": "An",
"FirstName": "Huazhang",
"Affiliation": "Department of Surgery, Changzheng Hospital, Shanghai 200003, China."
},
{
"LastName": "Zhang",
"FirstName": "Qinghua",
"Affiliation": "Department of Surgery, Changzheng Hospital, Shanghai 200003, China."
},
{
"LastName": "Yu",
"FirstName": "Yizhi",
"Affiliation": "Department of Surgery, Changzheng Hospital, Shanghai 200003, China. Electronic address: [email protected]."
},
{
"LastName": "Cao",
"FirstName": "Xuetao",
"Affiliation": "From the National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China. Electronic address: [email protected]."
}
] | Yes |
36093482 | Model Test and Numerical Simulation of Water Conservancy Foundation Bearing Capacity. | In order to further improve the construction quality of water conservancy projects under different soil conditions and ensure the safety, stability, and durability of water conservancy project foundation construction under special circumstances, this study takes the bearing capacity of water conservancy land foundation as the research direction, takes frozen soil foundation and bag gravel pier composite foundation as examples, and further optimizes the parameters of foundation bearing capacity by using the theory of foundation ultimate bearing capacity and related algorithms. The P-S curve of bearing capacity shows that when the foundation is frozen to -15°C and the foundation sum is about 190 kN, the P-S curve trend at this time changes significantly, which is not different from the indoor simulation result of 170 kN. The final numerical analysis of foundation bearing capacity is relatively reliable, which can provide a powerful reference for the calculation of foundation bearing capacity of hydraulic engineering. | 2022 | Computational intelligence and neuroscience | No DOI | [
{
"LastName": "Li",
"FirstName": "Jiajia",
"Affiliation": "College of Water Conservancy and Hydropower Engineering, Sichuan Agricultural University, Ya'an City, Sichuan Province 625014, China."
}
] | Yes |
38781659 | Cryo-EM structure of I domain-containing integrin αEβ7. | The integrin family is a transmembrane receptor that plays critical roles in the cell-cell and cell-extracellular matrix adhesion, signal transduction such as cell cycle regulation, organization of the intracellular cytoskeleton, and immune responses. Consequently, dysfunction of integrins is associated with a wide range of human diseases, including cancer and immune diseases, which makes integrins therapeutic targets for drug discovery. Here we report the cryo-EM structure of the human α-I domain-containing full-length integrin αEβ7, which is expressed in the leukocytes of the immune system and a drug target for inflammatory bowel disease (IBD). The structure reveals the half-bent conformation, an intermediate between the close and the open conformation, while the α-I domain responsible for the ligand binding covers the headpiece domain by a unique spatial arrangement. Our results provide the structural information for the drug design targeting IBD. | 2024 Aug 20 | Biochemical and biophysical research communications | No DOI | [
{
"LastName": "Akasaka",
"FirstName": "Hiroaki",
"Affiliation": "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan."
},
{
"LastName": "Sato",
"FirstName": "Dan",
"Affiliation": "Curreio, Inc., Room 357, South Clinical Research Laboratory, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8485, Japan."
},
{
"LastName": "Shihoya",
"FirstName": "Wataru",
"Affiliation": "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan."
},
{
"LastName": "Nureki",
"FirstName": "Osamu",
"Affiliation": "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan; Curreio, Inc., Room 357, South Clinical Research Laboratory, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8485, Japan. Electronic address: [email protected]."
},
{
"LastName": "Kise",
"FirstName": "Yoshiaki",
"Affiliation": "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan; Curreio, Inc., Room 357, South Clinical Research Laboratory, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8485, Japan. Electronic address: [email protected]."
}
] | No |
37357769 | Assessing the variation in amount of pressure exerted by haemostatic pressure bandages: a volunteer study. | We assess the range of pressures exerted by haemostatic compression bandages on upper limb arterial injuries. Maintaining a pink hand can act as a safety marker to prevent excessive bandage pressure and avert compression injuries. | 2023 Nov | The Journal of hand surgery, European volume | No DOI | [
{
"LastName": "Brzeszczyński",
"FirstName": "Filip",
"Affiliation": "Hooper Hand Unit, St. John's Hospital, Edinburgh, UK."
},
{
"LastName": "McGhee",
"FirstName": "James",
"Affiliation": "Hooper Hand Unit, St. John's Hospital, Edinburgh, UK."
},
{
"LastName": "Rust",
"FirstName": "Philippa",
"Affiliation": "Hooper Hand Unit, St. John's Hospital, Edinburgh, UK."
}
] | No |
24910788 | Comparing GlideScope Video Laryngoscope and Macintosh Laryngoscope Regarding Hemodynamic Responses During Orotracheal Intubation: A Randomized Controlled Trial. | To determine if the GlideScope® videolaryngoscope (GVL) could attenuate the hemodynamic responses to orotracheal intubation compared with conventional Macintosh laryngoscope. The aim of this relatively large randomized trial was to compare the hemodynamic stress responses during laryngoscopy and tracheal intubation using GVL versus MCL amongst healthy adult individuals receiving general anesthesia for elective surgeries. Ninety five healthy adult patients with American Society of Anesthesiologists physical status class I or II that were scheduled for elective surgery under general anesthesia were randomly allocated to either Macintosh or GlideScope arms. All patients received a standardized protocol of general anesthesia. Hemodynamic changes associated with intubation were recorded before and at 1, 3 and 5 minutes after the intubation. The time taken to perform endotracheal intubation was also noted in both groups. Immediately before laryngoscopy (pre-laryngoscopy), the values of all hemodynamic variables did not differ significantly between the two groups (All P values > 0.05). Blood pressures and HR values changed significantly over time within the groups. Time to intubation was significantly longer in the GlideScope (15.9 ± 6.7 seconds) than in the Macintosh group (7.8 ± 3.7 sec) (P< 0.001). However, there were no significant differences between the two groups in hemodynamic responses at all time points. The longer intubation time using GVL suggests that the benefit of GVL could become apparent if the time taken for orotracheal intubation could be decreased in GlideScope group. | 2014 Apr | Iranian Red Crescent medical journal | No DOI | [
{
"LastName": "Pournajafian",
"FirstName": "Ali Reza",
"Affiliation": "Department of Anaesthesiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IR Iran."
},
{
"LastName": "Ghodraty",
"FirstName": "Mohammad Reza",
"Affiliation": "Department of Anaesthesiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IR Iran."
},
{
"LastName": "Faiz",
"FirstName": "Seyed Hamid Reza",
"Affiliation": "Department of Anaesthesiology, Rasoul-Akram Medical Center, Iran University of Medical Sciences, Tehran, IR Iran."
},
{
"LastName": "Rahimzadeh",
"FirstName": "Poupak",
"Affiliation": "Department of Anaesthesiology, Rasoul-Akram Medical Center, Iran University of Medical Sciences, Tehran, IR Iran."
},
{
"LastName": "Goodarzynejad",
"FirstName": "Hamidreza",
"Affiliation": "Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, IR Iran."
},
{
"LastName": "Dogmehchi",
"FirstName": "Enseyeh",
"Affiliation": "Department of Anaesthesiology, Rasoul-Akram Medical Center, Iran University of Medical Sciences, Tehran, IR Iran."
}
] | No |
37735874 | METTL5-mediated 18S rRNA m(6)A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression. | Intrahepatic cholangiocarcinoma (ICC) is a deadly cancer with rapid tumor progression. While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA modifications promotes ICC development, the role of rRNA modifications remains elusive. Here, we found that 18S rRNA m[6]A modification and its methyltransferase METTL5 were aberrantly upregulated in ICC and associated with poorer survival (log rank test, p < 0.05). We further revealed the critical role of METTL5-mediated 18S rRNA m[6]A modification in regulation of ICC cell growth and metastasis using loss- and gain-of function assays in vitro and in vivo. The oncogenic function of METTL5 is corroborated using liver-specific knockout and overexpression ICC mouse models. Mechanistically, METTL5 depletion impairs 18S rRNA m[6]A modification that hampers ribosome synthesis and inhibits translation of G-quadruplex-containing mRNAs that are enriched in the transforming growth factor (TGF)-β pathway. Our study uncovers the important role of METTL5-mediated 18S rRNA m[6]A modification in ICC and unravels the mechanism of rRNA m[6]A modification-mediated oncogenic mRNA translation control. | 2023 Nov 1 | Molecular therapy : the journal of the American Society of Gene Therapy | No DOI | [
{
"LastName": "Dai",
"FirstName": "Zihao",
"Affiliation": "Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China."
},
{
"LastName": "Zhu",
"FirstName": "Wanjie",
"Affiliation": "Department of Gastroenterology, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong Province, China."
},
{
"LastName": "Hou",
"FirstName": "Yingdong",
"Affiliation": "Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China."
},
{
"LastName": "Zhang",
"FirstName": "Xinyue",
"Affiliation": "Cancer Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China."
},
{
"LastName": "Ren",
"FirstName": "Xuxin",
"Affiliation": "Cancer Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China."
},
{
"LastName": "Lei",
"FirstName": "Kai",
"Affiliation": "Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China."
},
{
"LastName": "Liao",
"FirstName": "Junbin",
"Affiliation": "Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China."
},
{
"LastName": "Liu",
"FirstName": "Haining",
"Affiliation": "Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China."
},
{
"LastName": "Chen",
"FirstName": "Zhihang",
"Affiliation": "Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China."
},
{
"LastName": "Peng",
"FirstName": "Sui",
"Affiliation": "Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China; Clinical Trials Unit, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China."
},
{
"LastName": "Li",
"FirstName": "Shaoqiang",
"Affiliation": "Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China. Electronic address: [email protected]."
},
{
"LastName": "Lin",
"FirstName": "Shuibin",
"Affiliation": "Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China. Electronic address: [email protected]."
},
{
"LastName": "Kuang",
"FirstName": "Ming",
"Affiliation": "Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong Province, China. Electronic address: [email protected]."
}
] | No |
26869098 | Synthesis of octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals and their structure-activity relationship for the decomposition of hydrazine in aqueous solution to hydrogen. | We developed a co-reduction method to synthesize octahedral, truncated octahedral, and cubic Rh2Ni nanocrystals. The shape/size distribution, structural characteristics, and composition of the Rh2Ni nanocrystals are investigated, and their possible formation mechanism at high temperatures in margaric acid/1-aminoheptadecane solution in the presence of tetraethylgermanium and borane trimethylamine complexes is proposed. A preliminary probing of the structure-activity dependence of the surface "clean" Rh2Ni nanocrystals supported on carbon towards hydrazine (N2H4) in aqueous solution dehydrogenation revealed that the higher the percentage of {111} facets, the higher is the activity and H2 selectivity of the nanocrystals. This result was attributed to the {111} facets not only introducing more basic sites, but also weakening the interaction between the produced adspecies (including H2 and NHx) and surface metal atoms in comparison with those of {100} facets. Furthermore, the as-prepared Rh2Ni nanooctahedra exhibited 100% H2 selectivity and high activity at room temperature for H2 generation via N2H4 decomposition. The activation energy of the Rh2Ni nanooctahedra was 41.6 ± 1.2 kJ mol(-1). The Rh2Ni nanooctahedra were stable catalysts for the hydrolytic dehydrogenation of N2H4, providing 27 723 total turnovers in 30 h. Our work provides a new perspective concerning the possibility of constructing hydrogen-producing systems based on N2H4 and surface "clean" Rh2Ni nanocrystal catalysts with defined shapes supported on carbon that possess a competitive performance in comparison with NaBH4 and NH3BH3 hydrogen-producing systems for fuel cell applications. | 2016 Apr 7 | Nanoscale | No DOI | [
{
"LastName": "Li",
"FirstName": "Chun",
"Affiliation": "Mineral Resources Chemistry Key Laboratory of Sichuan Higher Education Institutions, College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China. [email protected] and Collaborative Innovation Center of Panxi Strategic Mineral Resources Multi-purpose Utilization, Chengdu 610059, China."
},
{
"LastName": "Wang",
"FirstName": "Tao",
"Affiliation": "Mineral Resources Chemistry Key Laboratory of Sichuan Higher Education Institutions, College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China. [email protected] and Collaborative Innovation Center of Panxi Strategic Mineral Resources Multi-purpose Utilization, Chengdu 610059, China."
},
{
"LastName": "Chu",
"FirstName": "Wei",
"Affiliation": "College of Chemical Engineering and Key Laboratory of Green Chemistry & Technology of Ministry of Education, Sichuan University, Chengdu 610065, China. [email protected]."
},
{
"LastName": "Wu",
"FirstName": "Ping",
"Affiliation": "Mineral Resources Chemistry Key Laboratory of Sichuan Higher Education Institutions, College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China. [email protected] and Collaborative Innovation Center of Panxi Strategic Mineral Resources Multi-purpose Utilization, Chengdu 610059, China."
},
{
"LastName": "Tong",
"FirstName": "Dong Ge",
"Affiliation": "Mineral Resources Chemistry Key Laboratory of Sichuan Higher Education Institutions, College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China. [email protected] and Collaborative Innovation Center of Panxi Strategic Mineral Resources Multi-purpose Utilization, Chengdu 610059, China."
}
] | Yes |
25597312 | Role of human natural killer cells during Epstein-Barr virus infection. | Human natural killer (NK) cells have been suggested to restrict viral infections. However, the evidence for this notion is mostly circumstantial. Recent studies in mice with reconstituted human immune system components, children with symptomatic primary Epstein-Barr virus (EBV) infection, and in secondary lymphoid tissues of healthy EBV carriers have, however, shown that early differentiated human NK cells limit lytic EBV replication and thereby prevent the immunopathological expansion of lytic EBV antigen specific CD8+ T cells that is known as infectious mononucleosis (IM). These findings, which will be discussed in this review, might offer the opportunity to identify EBV negative adolescents at risk to develop IM, and also more generally provide a good example to document restriction of a viral infection by human NK cells. | 2014 | Critical reviews in immunology | No DOI | [
{
"LastName": "Münz",
"FirstName": "Christian",
"Affiliation": "Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland."
}
] | No |
28090218 | Role of T1 Mapping in Inherited Cardiomyopathies. | T1 mapping by cardiovascular magnetic resonance is a rapidly evolving method for the quantitative assessment of tissue characteristics in cardiac disease. The myocardial T1 time can be measured without contrast (native T1) or following the administration of intravenous gadolinium-based contrast agent (post-contrast T1). By combining both of these measures, the myocardial extracellular volume fraction can be approximated. This value has been validated histologically in various inherited cardiomyopathies. Due to overlapping phenotypes, the diagnosis of inherited cardiomyopathy can at times be challenging. In this article we discuss when T1 mapping may be a useful tool in the differential diagnosis of cardiomyopathy. We also present evidence of when T1 mapping provides incremental risk stratification over other biomarkers. | 2016 Winter | European cardiology | No DOI | [
{
"LastName": "Swoboda",
"FirstName": "Peter P",
"Affiliation": "Multidisciplinary Cardiovascular Research Centre and Division of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK."
},
{
"LastName": "McDiarmid",
"FirstName": "Adam K",
"Affiliation": "Guy's and St Thomas' NHS Foundation Trust, London, UK."
},
{
"LastName": "Page",
"FirstName": "Stephen P",
"Affiliation": "Inherited Cardiac Conditions Service, Leeds General Infirmary, Leeds, UK."
},
{
"LastName": "Greenwood",
"FirstName": "John P",
"Affiliation": "Multidisciplinary Cardiovascular Research Centre and Division of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK."
},
{
"LastName": "Plein",
"FirstName": "Sven",
"Affiliation": "Multidisciplinary Cardiovascular Research Centre and Division of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK."
}
] | No |
33779731 | RNA-Seq analysis reveals critical transcriptome changes caused by sodium butyrate in DN mouse models. | Diabetic nephropathy (DN)-a common complication of diabetes-is the primary cause of end-stage renal disease. Sodium butyrate (NaB) is a short-chain fatty acid (SCFA) that is a metabolic product of intestinal bacterium, and its protective effect on the kidney has been reported in cases of DN. However, its underlying mechanism remains unclear. The aim of the present study was to investigate the effect of NaB on globe transcriptome changes in DN. In our study, 8-week-old male db/db mice suffering from DN were randomly divided into two groups: the DN+NaB group (DN mice treated with NaB, 5 g/kg/day) and the DN group (DN mice treated with saline). Further, normal db/m mice were used as the normal control (NC) group. The blood glucose, body weight, urinary microalbumin and urinary creatinine of mice were measured for all three groups. Whole-transcriptome analysis was performed by RNA sequencing (RNA-Seq) to evaluate the profiling of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs). Bioinformatics analysis was performed to predict the potential NaB-related lncRNAs and genes in DN. The expressions of lncRNAs and mRNAs were tested using the quantitative real-time polymerase chain reactions (qRT-PCRs) in renal tissues and mesangial cells treated with NaB. The results of the present study demonstrated that NaB ameliorated renal dysfunction in DN mice. Moreover, RNA-Seq results identified that some lncRNAs and mRNAs were reversely changed in the DN+NaB group in comparison to those in the DN group. Additionally, the integrated co-expression networks of NaB-related lncRNAs revealed that these lncRNAs interacted with 155 key mRNAs. Furthermore, the co-expression network of inflammation-related lncRNAs and mRNAs demonstrated that those reversed lncRNAs and mRNAs also play essential roles in the inflammatory response. In summary, the present study suggests that NaB ameliorates diabetes-induced renal dysfunction and regulates transcriptome changes in DN. | 2021 Apr 30 | Bioscience reports | No DOI | [
{
"LastName": "Yang",
"FirstName": "Hansen",
"Affiliation": "Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China."
},
{
"LastName": "Zhang",
"FirstName": "Zheng",
"Affiliation": "Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China."
},
{
"LastName": "Peng",
"FirstName": "Rui",
"Affiliation": "Department of Bioinformatics, Chongqing Medical University, Chongqing 400016, China."
},
{
"LastName": "Zhang",
"FirstName": "Luyu",
"Affiliation": "Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China."
},
{
"LastName": "Liu",
"FirstName": "Handeng",
"Affiliation": "Experimental Teaching Center, Chongqing Medical University, Chongqing 400016, China."
},
{
"LastName": "Wang",
"FirstName": "Xinyi",
"Affiliation": "Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China."
},
{
"LastName": "Tian",
"FirstName": "Yiting",
"Affiliation": "Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China."
},
{
"LastName": "Sun",
"FirstName": "Yan",
"Affiliation": "Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China."
}
] | No |
35330598 | Local Privacy Protection for Sensitive Areas in Multiface Images. | The privacy protection for face images aims to prevent attackers from accurately identifying target persons through face recognition. Inspired by goal-driven reasoning (reverse reasoning), this paper designs a goal-driven algorithm of local privacy protection for sensitive areas in multiface images (face areas) under the interactive framework of face recognition algorithm, regional growth, and differential privacy. The designed algorithm, named privacy protection for sensitive areas (PPSA), is realized in the following manner: Firstly, the multitask cascaded convolutional network (MTCNN) was adopted to recognize the region and landmark of each face. If the landmark overlaps a subgraph divided from the original image, the subgraph will be taken as the seed for regional growth in the face area, following the growth criterion of the fusion similarity measurement mechanism (FSMM). Different from single-face privacy protection, multiface privacy protection needs to deal with an unknown number of faces. Thus, the allocation of the privacy budget ε directly affects the operation effect of the PPSA algorithm. In our scheme, the total privacy budget ε is divided into two parts: ε_1 and ε_2. The former is evenly allocated to each seed, according to the estimated number of faces ρ contained in the image, while the latter is allocated to the other areas that may consume the privacy budget through dichotomization. Unlike the Laplacian (LAP) algorithm, the noise error of the PPSA algorithm will not change with the image size, for the privacy protection is limited to the face area. The results show that the PPSA algorithm meets the requirements ε-Differential privacy, and image classification is realized by using different image privacy protection algorithms in different human face databases. The verification results show that the accuracy of the PPSA algorithm is improved by at least 16.1%, the recall rate is improved by at least 2.3%, and F1-score is improved by at least 15.2%. | 2022 | Computational intelligence and neuroscience | No DOI | [
{
"LastName": "Liu",
"FirstName": "Chao",
"Affiliation": "College of Computer Science and Technology, Harbin Engineering University, Harbin 150001, China."
},
{
"LastName": "Yang",
"FirstName": "Jing",
"Affiliation": "College of Computer Science and Technology, Harbin Engineering University, Harbin 150001, China."
},
{
"LastName": "Zhang",
"FirstName": "Xuan",
"Affiliation": "Information Center, First Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China."
},
{
"LastName": "Zhang",
"FirstName": "Yining",
"Affiliation": "Department of Computer Engineering, Daqing Vocational College, Daqing 163000, China."
},
{
"LastName": "Zhao",
"FirstName": "Weinan",
"Affiliation": "College of Communication and Electronic Engineering, Qiqihar University, Qiqihar 161000, China."
},
{
"LastName": "Miao",
"FirstName": "Fengjuan",
"Affiliation": "College of Communication and Electronic Engineering, Qiqihar University, Qiqihar 161000, China."
},
{
"LastName": "Shao",
"FirstName": "Yukun",
"Affiliation": "College of Communication and Electronic Engineering, Qiqihar University, Qiqihar 161000, China."
}
] | Yes |
35035852 | Research on Chest Disease Recognition Based on Deep Hierarchical Learning Algorithm. | Chest X-ray has become one of the most common ways in diagnostic radiology exams, and this technology assists expert radiologists with finding the patients at potential risk of cardiopathy and lung diseases. However, it is still a challenge for expert radiologists to assess thousands of cases in a short period so that deep learning methods are introduced to tackle this problem. Since the diseases have correlations with each other and have hierarchical features, the traditional classification scheme could not achieve a good performance. In order to extract the correlation features among the diseases, some GCN-based models are introduced to combine the features extracted from the images to make prediction. This scheme can work well with the high quality of image features, so backbone with high computation cost plays a vital role in this scheme. However, a fast prediction in diagnostic radiology is also needed especially in case of emergency or region with low computation facilities, so we proposed an efficient convolutional neural network with GCN, which is named SGGCN, to meet the need of efficient computation and considerable accuracy. SGGCN used SGNet-101 as backbone, which is built by ShuffleGhost Block (Huang et al., 2021) to extract features with a low computation cost. In order to make sufficient usage of the information in GCN, a new GCN architecture is designed to combine information from different layers together in GCNM module so that we can utilize various hierarchical features and meanwhile make the GCN scheme faster. The experiment on CheXPert datasets illustrated that SGGCN achieves a considerable performance. Compared with GCN and ResNet-101 (He et al., 2015) backbone (test AUC 0.8080, parameters 4.7M and FLOPs 16.0B), the SGGCN achieves 0.7831 (-3.08%) test AUC with parameters 1.2M (-73.73%) and FLOPs 3.1B (-80.82%), where GCN with MobileNet (Sandler and Howard, 2018) backbone achieves 0.7531 (-6.79%) test AUC with parameters 0.5M (-88.46%) and FLOPs 0.66B (-95.88%). | 2022 | Journal of healthcare engineering | No DOI | [
{
"LastName": "Li",
"FirstName": "Lingling",
"Affiliation": "Department of Central Laboratory, Children's Hospital of Shanghai Jiao Tong University, Shanghai, China."
},
{
"LastName": "Long",
"FirstName": "Yangyang",
"Affiliation": "School of Computing and Information System, University of Melbourne, Melbourne, Australia."
},
{
"LastName": "Huang",
"FirstName": "Bangtong",
"Affiliation": "School of Management, Shanghai University of Engineering Science, Shanghai, China."
},
{
"LastName": "Chen",
"FirstName": "Zihong",
"Affiliation": "College of Engineering, Shantou University, Shantou, China."
},
{
"LastName": "Liu",
"FirstName": "Zheng",
"Affiliation": "School of Management, Shanghai University of Engineering Science, Shanghai, China."
},
{
"LastName": "Yang",
"FirstName": "Zekun",
"Affiliation": "Department of Computer Science and Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China."
}
] | Yes |
31662911 | Comparing Four Video Laryngoscopes and One Optical Laryngoscope with a Standard Macintosh Blade in a Simulated Trapped Car Accident Victim. | Tracheal intubation still represents the "gold standard" in securing the airway of unconscious patients in the prehospital setting. Especially in cases of restricted access to the patient, video laryngoscopy became more and more relevant. The aim of the study was to evaluate the performance and intubation success of four different video laryngoscopes, one optical laryngoscope, and a Macintosh blade while intubating from two different positions in a mannequin trial with difficult access to the patient. A mannequin with a cervical collar was placed on the driver's seat. Intubation was performed with six different laryngoscopes either through the driver's window or from the backseat. Success, C/L score, time to best view (TTBV), time to intubation (TTI), and number of attempts were measured. All participants were asked to rate their favored device. Forty-two physicians participated. 100% of all intubations performed from the backseat were successful. Intubation success through the driver's window was less successful. Only with the Airtraq® optical laryngoscope, 100% success was achieved. Best visualization (window C/L 2a; backseat C/L 2a) and shortest TTBV (window 4.7 s; backseat 4.1 s) were obtained when using the D-Blade video laryngoscope, but this was not associated with a higher success through the driver's window. Fastest TTI was achieved through the window (14.2 s) when using the C-MAC video laryngoscope and from the backseat (7.3 s) when using a Macintosh blade. Video laryngoscopy revealed better results in visualization but was not associated with a higher success. Success depended on the approach and familiarity with the device. We believe that video laryngoscopy is suitable for securing airways in trapped accident victims. The decision for an optimal device is complicated and should be based upon experience and regular training with the device. | 2019 | Emergency medicine international | No DOI | [
{
"LastName": "Raimann",
"FirstName": "Florian J",
"Affiliation": "Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany."
},
{
"LastName": "Tepperis",
"FirstName": "Daniel M",
"Affiliation": "Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany."
},
{
"LastName": "Meininger",
"FirstName": "Dirk",
"Affiliation": "Main-Kinzig-Clinic, Department of Anesthesia, Intensive Care Medicine and Pain Therapy, Herzbachweg 14, 63571 Gelnhausen, Germany."
},
{
"LastName": "Zacharowski",
"FirstName": "Kai",
"Affiliation": "Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany."
},
{
"LastName": "Schalk",
"FirstName": "Richard",
"Affiliation": "Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany."
},
{
"LastName": "Byhahn",
"FirstName": "Christian",
"Affiliation": "Evangelical Hospital Oldenburg, Department of Anesthesia, Intensive Care Medicine and Pain Therapy, Steinweg 13-17, 26122 Oldenburg, Germany."
},
{
"LastName": "Weber",
"FirstName": "Christian F",
"Affiliation": "Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany."
},
{
"LastName": "Mutlak",
"FirstName": "Haitham",
"Affiliation": "Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany."
}
] | No |
36818387 | Differentiation of Small Gastrointestinal Stromal Tumor and Gastric Leiomyoma with Contrast-Enhanced CT. | The value of multiphase contrast-enhanced CT in differentiating gastrointestinal stromal tumors (GISTs) and gastric leiomyomas (GLMs) which were ≤3 cm was evaluated using machine learning. A retrospective analysis was conducted on 45 cases of small gastric wall submucosal tumors (including 22 GISTs and 23 GLMs) with pathologically confirmed diameter ≤3 cm and completed multiphase CT-enhanced scan images. The CT features including tumor location, maximum diameter, shape, margins, growth pattern, plain/enhanced CT value, cystic degeneration, calcification, ulcer, progressive reinforcement, perilesional lymph nodes, and the CT value ratio of the tumor to the aorta at the same level in the enhanced phase III scan of the two groups were evaluated. Tumor location and maximum diameter were automatically evaluated by machine learning. The GISTs and GLMs with a diameter ≤3 cm showed clear margins, uniform density on plain scan CT, and progressive homogeneous enhancement. The age of the GISTs is greater than that of the GLMs group. The plain scan CT value of the GISTs group was lower than that in the GLMs group. In the GISTs group, the lesions were mostly located in the fundus (68.18%), showing a mixed growth pattern (54.55%), and in the GLMs group, most lesions were located in the cardia (47.82%), showing an intraluminal growth pattern (95.65%). The abovementioned differences were statistically significant. Contrast-enhanced CT has limited value in differentiating small GISTs from GLMs, which are ≤3 cm. Older age (>49.0 years), a low plain CT value (<42.5 Hu), mixed growth inside and outside the cavity, and noncardiac location tended to be the criteria for the diagnosis of small GISTs of the gastric wall. | 2023 | Journal of healthcare engineering | No DOI | [
{
"LastName": "Yan",
"FirstName": "Mingyan",
"Affiliation": "Department of Radiology, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen 518000, China."
},
{
"LastName": "Liu",
"FirstName": "Yubao",
"Affiliation": "Imaging Center, Shenzhen Hospital of Southern Medical University, Shenzhen 518100, China."
},
{
"LastName": "You",
"FirstName": "Honglian",
"Affiliation": "Department of Radiology, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen 518000, China."
},
{
"LastName": "Zhao",
"FirstName": "Yanbo",
"Affiliation": "Imaging Center, Shenzhen Hospital of Southern Medical University, Shenzhen 518100, China."
},
{
"LastName": "Jin",
"FirstName": "Jun",
"Affiliation": "Department of Radiology, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen 518000, China."
},
{
"LastName": "Wang",
"FirstName": "Jing",
"Affiliation": "Department of Radiology, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen 518000, China."
}
] | No |
37843504 | Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation. | Dendritic cells (DCs), a driver of psoriasis pathogenesis, produce IL-23 and trigger IL-23/IL-17 cytokine axis activation. However, the mechanisms regulating IL-23 induction remain unclear. In the current study, we found that mice with E3 ligase FBXW7 deficiency in DCs show reduced skin inflammation correlated with the reduction of IL-23/IL-17 axis cytokines in the imiquimod-induced psoriasis model. Fbxw7 deficiency results in decreased production of IL-23 in DCs. FBXW7 interacts with the lysine N-methyltransferase suppressor of variegation 39 homolog 2 (SUV39H2), which catalyzes the trimethylation of histone H3 Lys9 (H3K9) during transcription regulation. FBXW7 mediates the ubiquitination and degradation of SUV39H2, thus decreasing H3K9m3 deposition on the Il23a promoter. The Suv39h2 knockout mice displayed exacerbated skin inflammation with the IL-23/IL-17 axis overactivating in the psoriasis model. Taken together, our results indicate that FBXW7 increases IL-23 expression in DCs by degrading SUV39H2, thereby aggravating psoriasis-like inflammation. Inhibition of FBXW7 or the FBXW7/SUV39H2/IL-23 axis may represent a novel therapeutic approach to psoriasis. | 2023 Dec 1 | Journal of immunology (Baltimore, Md. : 1950) | No DOI | [
{
"LastName": "Song",
"FirstName": "Yinjing",
"Affiliation": "Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Zhao",
"FirstName": "Xiangtong",
"Affiliation": "Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Qu",
"FirstName": "Hao",
"Affiliation": "Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Su",
"FirstName": "Yixin",
"Affiliation": "Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "He",
"FirstName": "Rukun",
"Affiliation": "Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Chen",
"FirstName": "Luxia",
"Affiliation": "Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Fang",
"FirstName": "Lutong",
"Affiliation": "Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Li",
"FirstName": "Jiaying",
"Affiliation": "Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Zou",
"FirstName": "Ziqi",
"Affiliation": "Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "He",
"FirstName": "Jia",
"Affiliation": "Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Li",
"FirstName": "Zilong",
"Affiliation": "Key Laboratory of Cardiovascular Disease, Department of Pathophysiology, Nanjing Medical University, Nanjing, China."
},
{
"LastName": "Xu",
"FirstName": "Yaohan",
"Affiliation": "Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Chen",
"FirstName": "Xin",
"Affiliation": "State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China."
},
{
"LastName": "Cheng",
"FirstName": "Hao",
"Affiliation": "Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Xu",
"FirstName": "Yong",
"Affiliation": "Key Laboratory of Cardiovascular Disease, Department of Pathophysiology, Nanjing Medical University, Nanjing, China."
},
{
"LastName": "Wang",
"FirstName": "Qingqing",
"Affiliation": "Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China."
},
{
"LastName": "Lai",
"FirstName": "Lihua",
"Affiliation": "Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China."
}
] | No |
38268793 | Prevalence and resistance characteristics of multidrug-resistant Streptococcus pneumoniae isolated from the respiratory tracts of hospitalized children in Shenzhen, China. | PCV13 introduction in China has led to a significant reduction of vaccine serotype Streptococcus pneumoniae. However, non-vaccine serotypes with highly resistance and invasiveness were often reported in the post-pneumococcal conjugate vaccine era and there was regional differences. A total of 669 S. pneumoniae strains were collected from the respiratory tracts of hospitalized children at Shenzhen Children's Hospital in 2021 and 2022. Antimicrobial resistance (AMR) characteristics were assessed through antibiotic susceptibility testing performed with the VITEK 2 compact system. AMR genes and single nucleotide polymorphisms (SNPs) in pbp1a, pbp2b, and pbp2x were identified via analysis of whole genome sequencing data. Statistical examination of the data was conducted employing chi-square and Fisher's exact tests. We found that non-vaccine serotypes strains had accounted for 46.6% of all the pneumococcal isolated strains. The most common non-vaccine serotype is 23A, with a prevalence rate of 8.9%, followed by 15A (6.6%), 6E (5.7%), 34 (3.2%), and 15B (2.9%). The multidrug resistance rates (MDR) of vaccine serotypes were 19F (99.36%), 19A (100%), 23F (98.08%), 6B (100%), and 6C (100%). Meanwhile, the MDR of non-vaccine serotypes were 15B (100.00%), 6E (100%), 15C (100%), 34 (95.24%), and 23A (98.31%). Resistance rates of 6E to more than six antibiotic classes reached 89.47%, which is similar to 19F (83.33%) and 19A (90%). Unique resistance profiles were also identified for non-vaccine serotypes, including significantly higher resistance to chloramphenicol in 6E, 15B, and 15C than in 19F and 19A. Furthermore, through genome sequencing, we revealed strong correlation of cat-TC with chloramphenicol resistance, patA/patB with tetracycline resistance, ermB and pmrA with erythromycin resistance. The introduction of PCV13 into China from 2017 has led to a shift in the dominant composition of pneumococcal strains. There has been a notable rise and spread of multidrug-resistant non-vaccine serotypes among children. Specifically, the non-vaccine serotype 6E, which was not widely reported in China previously, has emerged. To comprehend the resistance mechanisms, it is crucial to further investigate the molecular and genetic characteristics of these non-vaccine serotypes. | 2023 | Frontiers in cellular and infection microbiology | No DOI | [
{
"LastName": "Shi",
"FirstName": "Xing",
"Affiliation": "Department of Respiratory and Critical Care Medicine, Institute of Shenzhen Respiratory Diseases, The First Affiliated Hospital (Shenzhen People's Hospital), School of Medicine, Southern University of Science and Technology, Shenzhen, China."
},
{
"LastName": "Patil",
"FirstName": "Sandip",
"Affiliation": "Department of Haematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China."
},
{
"LastName": "Wang",
"FirstName": "Qing",
"Affiliation": "School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China."
},
{
"LastName": "Liu",
"FirstName": "Zihao",
"Affiliation": "Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, China."
},
{
"LastName": "Zhu",
"FirstName": "Chunqin",
"Affiliation": "Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, China."
},
{
"LastName": "Wang",
"FirstName": "Heping",
"Affiliation": "Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, China."
},
{
"LastName": "Chen",
"FirstName": "Yunshen",
"Affiliation": "Department of Clinical Microbiology Laboratory, Shenzhen Children's Hospital, Shenzhen, Guangdong, China."
},
{
"LastName": "Li",
"FirstName": "Liqiang",
"Affiliation": "Shenzhen Third People's Hospital, National Clinical Research Centre for Infectious Diseases, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China."
},
{
"LastName": "Yang",
"FirstName": "Liang",
"Affiliation": "Shenzhen Third People's Hospital, National Clinical Research Centre for Infectious Diseases, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China."
},
{
"LastName": "Zheng",
"FirstName": "Yuejie",
"Affiliation": "Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, China."
},
{
"LastName": "Dong",
"FirstName": "Shaowei",
"Affiliation": "Department of Haematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China."
},
{
"LastName": "Bao",
"FirstName": "Yanmin",
"Affiliation": "Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, China."
}
] | No |
32270268 | Climate change-driven elevational changes among boreal nocturnal moths. | Climate change has shifted geographical ranges of species northwards or to higher altitudes on elevational gradients. These changes have been associated with increases in ambient temperatures. For ectotherms in seasonal environments, however, life history theory relies largely on the length of summer, which varies somewhat independently of ambient temperature per se. Extension of summer reduces seasonal time constraints and enables species to establish in new areas as a result of over-wintering stage reaching in due time. The reduction of time constraints is also predicted to prolong organisms' breeding season when reproductive potential is under selection. We studied temporal change in the summer length and its effect on species' performance by combining long-term data on the occurrence and abundance of nocturnal moths with weather conditions in a boreal location at Värriötunturi fell in NE Finland. We found that summers have lengthened on average 5 days per decade from the late 1970s, profoundly due to increasing delays in the onset of winters. Moth abundance increased with increasing season length a year before. Most of the species occurrences expanded upwards in elevation. Moth communities in low elevation pine heath forest and middle elevation mountain birch forest have become inseparable. Yet, the flight periods have remained unchanged, probably due to unpredictable variation in proximate conditions (weather) that hinders life histories from selection. We conclude that climate change-driven changes in the season length have potential to affect species' ranges and affect the structure of insect assemblages, which may contribute to alteration of ecosystem-level processes. | 2020 Apr | Oecologia | No DOI | [
{
"LastName": "Keret",
"FirstName": "Netta M",
"Affiliation": "Ecology and Genetics Research Unit, University of Oulu, PO Box 3000, FI-90014, Oulu, Finland. [email protected]."
},
{
"LastName": "Mutanen",
"FirstName": "Marko J",
"Affiliation": "Ecology and Genetics Research Unit, University of Oulu, PO Box 3000, FI-90014, Oulu, Finland."
},
{
"LastName": "Orell",
"FirstName": "Markku I",
"Affiliation": "Ecology and Genetics Research Unit, University of Oulu, PO Box 3000, FI-90014, Oulu, Finland."
},
{
"LastName": "Itämies",
"FirstName": "Juhani H",
"Affiliation": "Ecology and Genetics Research Unit, University of Oulu, PO Box 3000, FI-90014, Oulu, Finland."
},
{
"LastName": "Välimäki",
"FirstName": "Panu M",
"Affiliation": "Ecology and Genetics Research Unit, University of Oulu, PO Box 3000, FI-90014, Oulu, Finland."
}
] | No |
36133159 | Water Environment Governance of Urban and Rural Spaces Integrating Natural Ecological Landscape Design Method. | The water environment is one of the basic elements that constitute the environment. It is an important place for the survival and development of human society, and it is also the most seriously disturbed and damaged area by humans. The pollution and destruction of water environment has become one of the major environmental problems in the world today. The essence of urban water space landscape design under the concept of integrating people's ecological design is the ecological landscape design of urban water spaces, while the development of ecological landscape design in the field of urban water space landscape design is still in its infancy, and the interpretation of its concept is also different. The ecological design of the landscape reflects a new dream of human beings, a new aesthetics and value: the true cooperative and fraternal relationship between man and nature. At present, the ecological design of urban water space landscape has not put forward a more accurate concept, clear principles and standards, and a complete and systematic theoretical basis, which requires further research, discussion, and continuous practice by this generation of designers to improve it. To this end, this paper proposed a research method on the integration of water environment governance in urban and rural spaces with natural ecological landscape design. This paper mainly talked about the status quo of water environment and its network sensor algorithm research and analyzed its coverage area one by one. Then, the water quality extraction is introduced in detail. And finally, the data analysis of the Beijing river waters, the analyzer rainfall, water quality, and so on are carried out in the experimental part. It could be seen from the experimental results that there were currently 22 reclaimed water plants in six urban areas of Beijing, with a daily water treatment capacity of 4.08 million cubic meters and a sewage treatment rate of 98%. As of 2016, 440 million cubic meters of reclaimed water has been reused. With the commissioning of the new reclaimed water system, the proportion of reclaimed water in the river and lake environment will continue to increase. | 2022 | Journal of environmental and public health | No DOI | [
{
"LastName": "Li",
"FirstName": "Jun",
"Affiliation": "College of Fine Art and Design, Hubei Engineering University, Xiaogan, 432000 Hubei, China."
}
] | Yes |
34027309 | Insights from mathematical modelling and quantitative analysis on the proposed 2030 goals for trachoma. | Trachoma is a neglected tropical disease and the leading infectious cause of blindness worldwide. The current World Health Organization goal for trachoma is elimination as a public health problem, defined as reaching a prevalence of trachomatous inflammation-follicular below 5% in children (1-9 years) and a prevalence of trachomatous trichiasis in adults below 0.2%. Current targets to achieve elimination were set to 2020 but are being extended to 2030. Mathematical and statistical models suggest that 2030 is a realistic timeline for elimination as a public health problem in most trachoma endemic areas. Although the goal can be achieved, it is important to develop appropriate monitoring tools for surveillance after having achieved the elimination target to check for the possibility of resurgence. For this purpose, a standardized serological approach or the use of multiple diagnostics in complement would likely be required. | 2019 | Gates open research | No DOI | [] | No |
35929504 | Hydroxygenkwanin suppresses proliferation, invasion and migration of osteosarcoma cells via the miR‑320a/SOX9 axis. | Hydroxygenkwanin (HGK) has an anticancer effect in a variety of tumors, but its role in osteosarcoma has not been explored. The purpose of the present study was to investigate the therapeutic effect of HGK on osteosarcoma and its specific molecular mechanism. Osteosarcoma cells (MG‑63 and U2OS) treated with various concentrations of HGK were assigned to the treatment group. MTT, clone formation, wound healing and Transwell assays were performed to assess the viability, proliferation, migration, and invasion of MG‑63 and U2OS cells. RT‑qPCR was conducted to quantify the expression levels of of microRNA (miR)‑320a and SRY‑box transcription factor 9 (SOX9) in MG‑63 and U2OS cells. The binding sites of miR‑320a and SOX9 were predicted by starBase database, and verified using the dual‑luciferase reporter assay. The expression levels of SOX9 and EMT‑related proteins (N‑cadherin, E‑cadherin and vimentin) were detected by western blot analysis. HGK inhibited cell proliferation, migration, invasion, but promoted the expression of miR‑320a in MG‑63 and U2OS cells. Downregulation of miR‑320a reversed the effects of HGK on proliferation, migration and invasion of MG‑63 and U2OS cells, while upregulation of miR‑320a had the opposite effect. HGK inhibited the expression of SOX9 by promoting the expression of miR‑320a. Upregulation of SOX9 could partially reverse miR‑320a‑induced migration and invasion of MG‑63 and U2OS cells. In addition, upregulation of miR‑320a promoted E‑cadherin expression and inhibited the expression of N‑cadherin and vimentin, and the effect of miR‑320a was also reversed by SOX9. In conclusion, HGK inhibited proliferation, migration and invasion of MG‑63 and U2OS cells through the miR‑320a/SOX9 axis. | 2022 Oct | Molecular medicine reports | No DOI | [
{
"LastName": "Dong",
"FirstName": "Xinli",
"Affiliation": "Department of Orthopedics, Traditional Chinese Medicine Hospital of Binzhou, Binzhou, Shandong 256600, P.R. China."
},
{
"LastName": "Wang",
"FirstName": "Yanhua",
"Affiliation": "Department of Nursing, Traditional Chinese Medicine Hospital of Binzhou, Binzhou, Shandong 256600, P.R. China."
},
{
"LastName": "Zhuang",
"FirstName": "Hua",
"Affiliation": "Department of Orthopedics, Traditional Chinese Medicine Hospital of Binzhou, Binzhou, Shandong 256600, P.R. China."
},
{
"LastName": "An",
"FirstName": "Gang",
"Affiliation": "Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China."
}
] | No |
27696086 | Adenosine A(2A) receptor regulates expression of vascular endothelial growth factor in feto-placental endothelium from normal and late-onset pre-eclamptic pregnancies. | We aim to investigate whether A2A/nitric oxide-mediated regulation of vascular endothelial growth factor (VEGF) expression is impaired in feto-placental endothelial cells from late-onset pre-eclampsia. Cultures of human umbilical vein endothelial cells (HUVECs) and human placental microvascular endothelial cells (hPMECs) from normal and pre-eclamptic pregnancies were used. Assays by using small interference RNA (siRNA) for A2A were performed, and transfected cells were used for estimation of messenger RNA (mRNA) levels of VEGF, as well as for cell proliferation and angiogenesis in vitro. CGS-21680 (A2A agonist, 24 h) increases HUVEC and hPMEC proliferation in a dose response manner. Furthermore, similar to CGS-21680, the nitric oxide donor, S-nitroso-N-acetyl-penicillamine oxide (SNAP), increased cell proliferation in a dose response manner (logEC50 10[-9.2] M). In hPMEC, CGS-21680 increased VEGF protein levels in both normal (∼1.5-fold) and pre-eclamptic pregnancies (∼1.2-fold), an effect blocked by the A2A antagonist, ZM-241385 (10[-5] M) and the inhibitor of NO synthase, N ω-nitro-L-arginine methyl ester hydrochloride (L-NAME). Subsequently, SNAP partially recovered cell proliferation and in vitro angiogenesis capacity of cells from normal pregnancies exposed to siRNA for A2A. CGS-21680 also increased (∼1.5-fold) the level of VEGF mRNA in HUVEC from normal pregnancies, but not in pre-eclampsia. Additionally, transfection with siRNA for A2A decrease (∼30 %) the level of mRNA for VEGF in normal pregnancy compared to untransfected cells, an effect partially reversed by co-incubation with SNAP. The A2A-NO-VEGF pathway is present in endothelium from microcirculation and macrocirculation in both normal and pre-eclamptic pregnancies. However, NO signaling pathway seems to be impaired in HUVEC from pre-eclampsia. | 2017 Mar | Purinergic signalling | No DOI | [
{
"LastName": "Acurio",
"FirstName": "Jesenia",
"Affiliation": "Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, Universidad del Bío-Bío, Chillán, Chile."
},
{
"LastName": "Herlitz",
"FirstName": "Kurt",
"Affiliation": "Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, Universidad del Bío-Bío, Chillán, Chile."
},
{
"LastName": "Troncoso",
"FirstName": "Felipe",
"Affiliation": "Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, Universidad del Bío-Bío, Chillán, Chile."
},
{
"LastName": "Aguayo",
"FirstName": "Claudio",
"Affiliation": "Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, Concepción, Chile."
},
{
"LastName": "Bertoglia",
"FirstName": "Patricio",
"Affiliation": "Obstetric and Gynecology Department, Hospital Clinico Herminda Martin, Chillán, Chile, Universidad Católica de la Santísima Concepción, Concepción, Chile."
},
{
"LastName": "Escudero",
"FirstName": "Carlos",
"Affiliation": "Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, Universidad del Bío-Bío, Chillán, Chile. [email protected]."
}
] | No |
37307966 | Arjunolic acid modulate pancreatic dysfunction by ameliorating pattern recognition receptor and canonical Wnt pathway activation in type 2 diabetic rats. | Arjunolic acid (AA) is a potent phytochemical with multiple therapeutics effects. In this study, AA is evaluated on type 2 diabetic (T2DM) rats to understand the mechanism of β-cell linkage with Toll-like receptor 4 (TLR-4) and canonical Wnt signaling. However, its role in modulating TLR-4 and canonical Wnt/β-catenin crosstalk on insulin signaling remains unclear during T2DM. Aim The current study is aimed to examine the potential role of AA on insulin signaling and TLR-4-Wnt crosstalk in the pancreas of type 2 diabetic rats. Multiple methods were used to determine molecular cognizance of AA in T2DM rats, when treated with different dosage levels. Histopathological and histomorphometry analysis was conducted using masson trichrome and H&E stains. While, protein and mRNA expressions of TLR-4/Wnt and insulin signaling were assessed using automated Western blotting (jess), immunohistochemistry, and RT-PCR. Histopathological findings revealed that AA had reversed back the T2DM-induced apoptosis and necrosis caused to rats pancreas. Molecular findings exhibited prominent effects of AA in downregulating the elevated level of TLR-4, MyD88, NF-κB, p-JNK, and Wnt/β-catenin by blocking TLR-4/MyD88 and canonical Wnt signaling in diabetic pancreas, while IRS-1, PI3K, and pAkt were all upregulated by altering the NF-κB and β-catenin crosstalk during T2DM. Overall results, indicate that AA has potential to develop as an effective therapeutic in the treatment of T2DM associated meta-inflammation. However, future preclinical research at multiple dose level in a long-term chronic T2DM disease model is warranted to understand its clinical relevance in cardiometabolic disease. | 2023 Aug 15 | Life sciences | No DOI | [
{
"LastName": "Aamir",
"FirstName": "Khurram",
"Affiliation": "School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia; Akhtar Saeed College of Pharmacy, Canal Campus, Lahore, Pakistan."
},
{
"LastName": "Sethi",
"FirstName": "Gautam",
"Affiliation": "Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore."
},
{
"LastName": "Afrin",
"FirstName": "Mst Rejina",
"Affiliation": "Department of Pharmacy, Faculty of Sciences and Engineering, East West University, Dhaka 1212, Bangladesh."
},
{
"LastName": "Hossain",
"FirstName": "Chowdhury Faiz",
"Affiliation": "Department of Pharmacy, Faculty of Sciences and Engineering, East West University, Dhaka 1212, Bangladesh."
},
{
"LastName": "Jusuf",
"FirstName": "Patricia Regina",
"Affiliation": "School of Biosciences, Faculty of Sciences, University of Melbourne, Parkville, VIC, Australia."
},
{
"LastName": "Sarker",
"FirstName": "Satyajit D",
"Affiliation": "Centre for Natural Product Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom."
},
{
"LastName": "Arya",
"FirstName": "Aditya",
"Affiliation": "School of Biosciences, Faculty of Sciences, University of Melbourne, Parkville, VIC, Australia; Centre for Natural Product Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom; Department of Pharmacology & Therapeutics, School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia. Electronic address: [email protected]."
}
] | No |
36801595 | Risk factors for and consequences of difficult fetal extraction in emergency caesarean section. A retrospective registry-based cohort study. | This study aimed to assess risk factors for difficult fetal extraction in emergency caesarean sections, focusing on top-up epidural anesthesia compared to spinal anesthesia. Additionally, this study addressed consequences of difficult fetal extraction on neonatal and maternal morbidity. This retrospective registry-based cohort study included 2,332 of 2,892 emergency caesarean sections performed with local anesthesia during 2010-2017. Main outcomes were analyzed by crude and multiple adjusted logistic regression providing odds ratios. Difficult fetal extraction was found in 14.9% of emergency caesarean sections. Risk-factors for difficult fetal extraction included top-up epidural anesthesia (aOR:1.37[95 %CI 1.04-1.81]), high pre-pregnancy BMI (aOR:1.41[95 %CI 1.05-1.89]), deep fetal descent (ischial spine: aOR:2.53[95 %CI 1.89-3.39], pelvic floor: aOR:3.11[95 %CI 1.32-7.33]), and anterior placental position (aOR:1.37[95 %CI 1.06-1.77]). Difficult fetal extraction was associated with increased risk of low umbilical artery pH 7.00-7.09 (aOR:3.50[95 %CI 1.98-6.15]) pH ≤ 6.99 (aOR:4.20[95 %CI 1.61-10.91]), five-minute Apgar score ≤ 6 (aOR:3.41[95 %CI 1.49-7.83]) and maternal blood loss (501-1,000 ml: aOR:1.65[95 %CI 1.27-2.16], 1,001-1,500 ml: aOR:3.24[95 %CI 2.24-4.67], 1,501-2,000 ml: aOR:3.94[95 %CI 2.24-6.94] and ≥ 2001 ml: aOR:2.76[95 %CI 1.12-6.82]). This study identified four risk factors for difficult fetal extraction in emergency caesarean section: top-up epidural anesthesia, high maternal BMI, deep fetal descent and anterior placental position. Additionally, difficult fetal extraction was associated with poor neonatal and maternal outcomes. | 2023 Apr | European journal of obstetrics, gynecology, and reproductive biology | No DOI | [
{
"LastName": "Ammitzbøll",
"FirstName": "I L A",
"Affiliation": "Department of Obstetrics and Gynecology, Nordsjællands Hospital, Denmark; Nordsjællands Hospital, 3400 Hillerød, Denmark. Electronic address: [email protected]."
},
{
"LastName": "Andersen",
"FirstName": "B R",
"Affiliation": "Department of Obstetrics and Gynecology, Nordsjællands Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark; Nordsjællands Hospital, 3400 Hillerød, Denmark."
},
{
"LastName": "Lange",
"FirstName": "K H W",
"Affiliation": "Department of Clinical Medicine, University of Copenhagen, Denmark; Department of Anesthesiology, Nordsjællands Hospital, Denmark; Nordsjællands Hospital, 3400 Hillerød, Denmark."
},
{
"LastName": "Clausen",
"FirstName": "T",
"Affiliation": "Department of Obstetrics and Gynecology, Nordsjællands Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark; Nordsjællands Hospital, 3400 Hillerød, Denmark."
},
{
"LastName": "Løkkegaard",
"FirstName": "E C L",
"Affiliation": "Department of Obstetrics and Gynecology, Nordsjællands Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark; Nordsjællands Hospital, 3400 Hillerød, Denmark."
}
] | No |
38993467 | Emerging Themes and Research Frontiers in Suicide Prediction: A Scientometric Analysis. | Suicide remains a critical global health issue despite advancements in mental health treatment. The purpose of this analysis is to emphasize the development, patterns, and noteworthy outcomes of suicide prediction research. It also helps to uncover gaps and areas of under-researched topics within suicide prediction. A scientometric analysis was conducted using Biblioshiny and VOSviewer. To thoroughly assess the academic literature on suicide prediction, various scientometric methodologies such as trend analysis and citation analysis were employed. We utilized the temporal features of the Web of Science to analyze publication trends over time. Author affiliation data were used to investigate the geographic distribution of research. Cluster analysis was performed by grouping related keywords into clusters to identify overarching themes within the literature. A total of 1,703 articles from 828 different sources, spanning from 1942 to 2023, were collected for the analysis. Machine learning techniques might have a big influence on suicide-related event prediction, which would enhance attempts at suicide prevention and intervention. The conceptual understanding of suicide prediction is enhanced by scientometric analysis, which further uncovers the research gap and literature in this area. Suicide prediction research underscores that suicidal behavior is not caused by a single factor but is the result of a complex interplay of multiple factors. These factors may include biological, psychological, social, and environmental factors. Understanding and integrating these factors into predictive models is a theoretical advancement in the field. Unlike previous bibliometric studies in the field of suicide prediction that have typically focused on specific subtopics or data sources, our analysis offers a comprehensive mapping of the entire landscape. We encompass a wide range of suicide prediction literature, including research from medical, psychological, and social science domains, thus providing a holistic overview. | 2024 Jun | Cureus | No DOI | [
{
"LastName": "Abraham",
"FirstName": "Kochumol",
"Affiliation": "Department of Computer Applications, Marian College Kuttikkanam, Peermade, IND."
},
{
"LastName": "K R",
"FirstName": "Anish",
"Affiliation": "Department of Social Work, Rajagiri College of Social Sciences, Kalamassery, IND."
},
{
"LastName": "Toms",
"FirstName": "Greety",
"Affiliation": "Department of Library and Information Sciences, Bharta Mata College, Thrikkakara, IND."
},
{
"LastName": "Francis P",
"FirstName": "Nice Mary",
"Affiliation": "Department of Psychology, Prajyoti Niketan College, Thrissur, IND."
},
{
"LastName": "Babu",
"FirstName": "Jobi",
"Affiliation": "Department of Social Work, Marian College Kuttikkanam, Peermade, IND."
}
] | No |
32038375 | Psychological Capital and University Students' Entrepreneurial Intention in China: Mediation Effect of Entrepreneurial Capitals. | The aim of this study was to identify the influences of psychological capital (PC) on students' entrepreneurial intention (EI) in China's universities. The mediating effects of Entrepreneurial Capitals were also examined. Based on the analysis of the traditional capital and PC, the paper proposes that traditional capital is the direct factor to drive the behavior of entrepreneurship, while psychological factors do not directly affect EI, but improve EI by influencing traditional capital. A total of 1914 responses from universities in southeast China were analyzed using the structural equation modeling (SEM) approach to test study hypotheses. Results show that PC has a significant indirect impact on students' EI only through traditional financial, human, and social capital (SC). These results support the mediating role of the traditional entrepreneurial capitals in explaining the relationship between PC and EI. Additionally, the impact of SC on EI is higher than that of financial and human capital (HC). Finally, research limitations and implications are discussed and future research directions are suggested. | 2019 | Frontiers in psychology | No DOI | [
{
"LastName": "Zhao",
"FirstName": "Jianbo",
"Affiliation": "Institute of Industrial Economics, Chinese Academy of Social Sciences, Beijing, China."
},
{
"LastName": "Wei",
"FirstName": "Guojiang",
"Affiliation": "School of Economics, Fujian Normal University, Fuzhou, China."
},
{
"LastName": "Chen",
"FirstName": "Kou-Hsiung",
"Affiliation": "Department of Business Administration, Cheng Shiu University, Kaohsiung City, Taiwan."
},
{
"LastName": "Yien",
"FirstName": "Jui-Mei",
"Affiliation": "Department of Business Administration, University of Kang Ning, Tainan, Taiwan."
}
] | No |
12696621 | International Session Award. Non-invasive cutaneous cardiovascular dynamics (CVD) as a predictor of preterm delivery: a pilot study. | To assess the clinical value of cardiovascular dynamics (CVD) pattern of 'positive cycling' in predicting true preterm labor. Patients with a clinical diagnosis of preterm labor had CVD measurement with a non-invasive miniature pressure transducer applied to the fingertip concomitantly with uterine activity monitoring. Based on previous work by our group, the rapid ejection time (RET) reflects arterial compliance; an elevated RET is suggestive of vasoconstriction. Positive cycling is present when the RET shows elevation with uterine contractions and negative cycling is present when there are no changes in the RET with uterine contractions. Twenty-seven women had negative CVD cycling and nine had positive CVD cycling. There was no difference between the two groups in initial gestational age, cervical effacement or cervical dilation at testing. However, the mean interval from testing to delivery was 1.56 (SEM+/-0.29) days for positive cycling and 39 days (+/-5.25) for negative cycling (P < 0.001). Non-invasive cardiovascular patterns of positive cycling appear predictive of preterm delivery. | 2003 Feb | The journal of obstetrics and gynaecology research | No DOI | [
{
"LastName": "Ogunyemi",
"FirstName": "Dotun",
"Affiliation": "Department of Obstetrics and Gynecology, King/Drew Medical Center, Los Angeles, California 90059, USA. [email protected]"
},
{
"LastName": "Vargas",
"FirstName": "Noemi",
"Affiliation": ""
},
{
"LastName": "Fukushima",
"FirstName": "Teiichiro",
"Affiliation": ""
},
{
"LastName": "Hon",
"FirstName": "Edward",
"Affiliation": ""
}
] | Yes |
36304254 | Comprehensive Analysis of the Oncogenic Role of Targeting Protein for Xklp2 (TPX2) in Human Malignancies. | Mitosis and spindle assembly require the microtubule-associated protein Xenopus kinesin-like protein 2 (TPX2). Although TPX2 is highly expressed in several malignant tumor forms, little is known about its role in cancer. In this study, we performed the gene set enrichment analysis of TPX2 in 33 types of cancers and an extensive pan-cancer bioinformatic analysis using prognosis, tumor mutational burdens, microsatellite instability, tumor microenvironment, and immune cell infiltration data. According to the differential expression study, TPX2 was found to be overexpressed across all studied cancer types. Based on the survival analysis, increased TPX2 expression was associated with a poor prognosis for most cancers. The TPX2 expression level was confirmed to correlate with the clinical stage, microsatellite instability, and tumor mutational burden across all cancer types. Furthermore, TPX2 expression has been linked to tumor microenvironments and immune cell infiltration, particularly in bladder urothelial carcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, stomach adenocarcinoma, and uterine corpus endometrial carcinoma. Finally, the gene set enrichment analysis implicated TPX2 in the regulation of aminoacyl tRNA biosynthesis, which is the most important tumor cell cycle signaling pathway. This comprehensive pan-cancer analysis shows that TPX2 is a prognostic molecular biomarker for most cancers and suggests its potential as an effective therapeutic target for the treatment of these diseases. | 2022 | Disease markers | No DOI | [
{
"LastName": "Shao",
"FirstName": "Ting",
"Affiliation": "Department of Gynecology, Affiliated Hospital of Chifeng University, Chifeng 024000, China."
},
{
"LastName": "Jiang",
"FirstName": "Xiling",
"Affiliation": "Department of Stomatology, Affiliated Hospital of Chifeng University, Chifeng 024000, China."
},
{
"LastName": "Bao",
"FirstName": "Guochang",
"Affiliation": "Department of Urology, Affiliated Hospital of Chifeng University, Chifeng 024000, China."
},
{
"LastName": "Li",
"FirstName": "Chunsheng",
"Affiliation": "Department of Urology, Affiliated Hospital of Chifeng University, Chifeng 024000, China."
},
{
"LastName": "Guo",
"FirstName": "Changgang",
"Affiliation": "Inner Mongolia Key Laboratory of Oral Craniofacial Diseases, Chifeng University, Chifeng 024000, China."
}
] | No |
36561618 | Treatment of progressive ischemic stroke with low‑dose eptifibatide: A retrospective case‑control study. | Progressive ischemic stroke (PIS) is a therapeutic challenge in clinical practice. The present retrospective study aimed to investigate the safety and effectiveness of eptifibatide in the treatment of PIS. The present study enrolled patients with PIS admitted to Xiangtan Central Hospital (Xiangtan, China) between March 2020 and March 2021 with National Institutes of Health Stroke Scale (NIHSS) progression scores of ≥2 points during the initial 72 h. Patients were then divided into two groups according to their different anti-platelet treatment regimens. The control group was administered anti-platelet aggregation with aspirin 100 mg/day, or aspirin 100 mg/day in combination with clopidogrel 75 mg/day, whilst eptifibatide was administered in the eptifibatide group in addition to the treatment regimen used in the control group. Changes in NIHSS scores at the time of progression and 7 days after treatment (∆NIHSS) were used to assess early neurological recovery, and there were no significant differences in ∆NIHSS and adverse reactions between the groups (P>0.05). Subgroup analysis was subsequently performed according to the type of blood vessel that was involved [large artery atherosclerosis (LAA) or small artery occlusion (SAO)]. For the SAO subgroup, the ∆NIHSS in the eptifibatide group was significantly superior to that of the control group (P=0.008), while for the LAA subgroup, there were no significant differences in ∆NIHSS between groups (P=0.334). The present retrospective study found that patients with PIS tolerated eptifibatide treatment well. Eptifibatide exerted different effects on patients with acute PIS involving different types of blood vessels compared with oral antiplatelet drugs. In addition, application of eptifibatide may lead to faster and earlier recovery in patients with SAO, but not in those with LAA. Low-dose eptifibatide is a safe and effective treatment option for patients with PIS caused by SAO. | 2023 Jan | Experimental and therapeutic medicine | No DOI | [
{
"LastName": "Luo",
"FirstName": "Long",
"Affiliation": "Department of Neurology, Xiangtan Central Hospital, Xiangtan, Hunan 411100, P.R. China."
},
{
"LastName": "Lin",
"FirstName": "Jinsheng",
"Affiliation": "Department of Neurology, Xiangtan Central Hospital, Xiangtan, Hunan 411100, P.R. China."
},
{
"LastName": "Deng",
"FirstName": "Ye",
"Affiliation": "Department of Neurology, Xiangtan Central Hospital, Xiangtan, Hunan 411100, P.R. China."
},
{
"LastName": "Li",
"FirstName": "Zhigang",
"Affiliation": "Department of Neurology, Xiangtan Central Hospital, Xiangtan, Hunan 411100, P.R. China."
},
{
"LastName": "Yuan",
"FirstName": "Ying",
"Affiliation": "Department of Neurology, Xiangtan Central Hospital, Xiangtan, Hunan 411100, P.R. China."
},
{
"LastName": "Zhang",
"FirstName": "Wen",
"Affiliation": "Department of Neurology, Xiangtan Central Hospital, Xiangtan, Hunan 411100, P.R. China."
}
] | No |
37983626 | Identification and immunological characterization of cuproptosis-related molecular clusters in ischemic stroke. | The present study elucidated cuproptosis-related molecular clusters involved in ischemic stroke and developed predictive models. Transcriptomic and immunological profiles of ischemic stroke-related datasets were extracted from the Gene Expression Omnibus database. Next, we conducted weighted gene co-expression network analysis to determine cluster-specific differentially expressed genes (DEGs). Models such as random forest and eXtreme gradient boosting (XGB) were evaluated to select the best prediction performance model. Subsequently, we validated the model's predictive efficiency by using nomograms, decision curve analysis, calibration curves, and receiver operating characteristic curve analysis with an external dataset. We identified two cuproptosis-related clusters involved in ischemic stroke. The DEGs in Cluster 2 were closely associated with amino acid metabolism, various immune responses, and cell proliferation pathways. The XGB model showed lower residuals, a smaller root mean square error, and a greater area under the curve value (AUC = 0.923), thus exhibiting the best discriminative performance. The AUC value for the external validation dataset was 0.921, thus confirming the high performance of the model. NFE2L2, NLRP3, GLS, LIPT1, and MTF1 were identified as potential cuproptosis predictors, thus shedding new light on ischemic stroke pathogenesis and heterogeneity. | 2024 Jan 3 | Neuroreport | No DOI | [
{
"LastName": "Liu",
"FirstName": "Chunhua",
"Affiliation": "Department of Rehabilitation Research, Lishui Hospital of Traditional Chinese Medicine Affiliated to the Zhejiang University of Chinese Medicine."
},
{
"LastName": "Wu",
"FirstName": "Binbin",
"Affiliation": "Department of Rehabilitation Research, Lishui Hospital of Traditional Chinese Medicine Affiliated to the Zhejiang University of Chinese Medicine."
},
{
"LastName": "Tao",
"FirstName": "Yongjun",
"Affiliation": "Department of Rehabilitation Research, Lishui Hospital of Traditional Chinese Medicine Affiliated to the Zhejiang University of Chinese Medicine."
},
{
"LastName": "Liu",
"FirstName": "Xiang",
"Affiliation": "Department of Rehabilitation Research, Lishui Hospital of Traditional Chinese Medicine Affiliated to the Zhejiang University of Chinese Medicine."
},
{
"LastName": "Lou",
"FirstName": "Xiqiang",
"Affiliation": "Department of Rehabilitation Research, Lishui Hospital of Traditional Chinese Medicine Affiliated to the Zhejiang University of Chinese Medicine."
},
{
"LastName": "Wang",
"FirstName": "Zhen",
"Affiliation": "Department of Rehabilitation Research, Lishui Hospital of Traditional Chinese Medicine Affiliated to the Zhejiang University of Chinese Medicine."
},
{
"LastName": "Guo",
"FirstName": "Zhaofu",
"Affiliation": "Department of Rehabilitation Research, Lishui Hospital of Traditional Chinese Medicine Affiliated to the Zhejiang University of Chinese Medicine."
},
{
"LastName": "Tang",
"FirstName": "Dongmei",
"Affiliation": "Department of Rehabilitation Research, Lishui Second People's Hospital, Zhejiang, China."
}
] | No |
38229396 | Beta-cell compensation and gestational diabetes. | Gestational diabetes mellitus (GDM) is characterized by glucose intolerance in pregnant women without a previous diagnosis of diabetes. While the etiology of GDM remains elusive, the close association of GDM with increased maternal adiposity and advanced gestational age implicates insulin resistance as a culpable factor for the pathogenesis of GDM. Pregnancy is accompanied by the physiological induction of insulin resistance in the mother secondary to maternal weight gain. This effect serves to spare blood glucose for the fetus. To overcome insulin resistance, maternal β-cells are conditioned to release more insulin into the blood. Such an adaptive response, termed β-cell compensation, is essential for maintaining normal maternal metabolism. β-cell compensation culminates in the expansion of β-cell mass and augmentation of β-cell function, accounting for increased insulin synthesis and secretion. As a result, a vast majority of mothers are protected from developing GDM during pregnancy. In at-risk pregnant women, β-cells fail to compensate for maternal insulin resistance, contributing to insulin insufficiency and GDM. However, gestational β-cell compensation ensues in early pregnancy, prior to the establishment of insulin resistance in late pregnancy. How β-cells compensate for pregnancy and what causes β-cell failure in GDM are subjects of investigation. In this mini-review, we will provide clinical and preclinical evidence that β-cell compensation is pivotal for overriding maternal insulin resistance to protect against GDM. We will highlight key molecules whose functions are critical for integrating gestational hormones to β-cell compensation for pregnancy. We will provide mechanistic insights into β-cell decompensation in the etiology of GDM. | 2023 Dec | The Journal of biological chemistry | No DOI | [
{
"LastName": "Usman",
"FirstName": "Taofeek O",
"Affiliation": "Division of Endocrinology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."
},
{
"LastName": "Chhetri",
"FirstName": "Goma",
"Affiliation": "Division of Endocrinology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."
},
{
"LastName": "Yeh",
"FirstName": "Hsuan",
"Affiliation": "Division of Endocrinology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."
},
{
"LastName": "Dong",
"FirstName": "H Henry",
"Affiliation": "Division of Endocrinology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address: [email protected]."
}
] | No |
24193316 | Prospective relationship between hemispheric lateralisation and CD4+ T cells in human immunodeficiency virus type 1. | Neuromodulation of the immune system has been proposed to be influenced by hemispheric lateralisation (HL). The present study tested whether HL predicted CD4+ levels, statistically controlling for confounders. Employing two assessments of HL, 68 human immunodeficiency virus (HIV)-1+ patients were followed prospectively. Numerous exclusion criteria and confounder assessments were employed (e.g. age/medication). Left HL significantly positively predicted CD4+ levels at follow-up, and this was qualified by medication (HAART) status: only in HAART-naïve patients did HL predict CD4 levels. Furthermore, HL significantly predicted whether patients had clinically significantly high/low CD4+ counts. Using a more rigorous methodology than a previous study, the present work partly corroborated the theory of HL influences on immunity, extended it to HIV immunity and identified a possible moderator: HAART medication. Implications for future research and treatments are provided. | 2014 | Neuroimmunomodulation | No DOI | [
{
"LastName": "Sumner",
"FirstName": "Rachel C",
"Affiliation": "Centre for Rehabilitation Research,Brunel University, Uxbridge, UK."
},
{
"LastName": "Nowicky",
"FirstName": "Alexander V",
"Affiliation": ""
},
{
"LastName": "Parton",
"FirstName": "Andrew",
"Affiliation": ""
},
{
"LastName": "Wylock",
"FirstName": "Carolien",
"Affiliation": ""
},
{
"LastName": "Cserjesi",
"FirstName": "Renata",
"Affiliation": ""
},
{
"LastName": "Fischler",
"FirstName": "Benjamin",
"Affiliation": ""
},
{
"LastName": "Lacor",
"FirstName": "Patrick",
"Affiliation": ""
},
{
"LastName": "Gidron",
"FirstName": "Yori",
"Affiliation": ""
}
] | No |
27992882 | Orphan receptor ligand discovery by pickpocketing pharmacological neighbors. | Understanding the pharmacological similarity of G protein-coupled receptors (GPCRs) is paramount for predicting ligand off-target effects, drug repurposing, and ligand discovery for orphan receptors. Phylogenetic relationships do not always correctly capture pharmacological similarity. Previous family-wide attempts to define pharmacological relationships were based on three-dimensional structures and/or known receptor-ligand pairings, both unavailable for orphan GPCRs. Here, we present GPCR-CoINPocket, a novel contact-informed neighboring pocket metric of GPCR binding-site similarity that is informed by patterns of ligand-residue interactions observed in crystallographically characterized GPCRs. GPCR-CoINPocket is applicable to receptors with unknown structure or ligands and accurately captures known pharmacological relationships between GPCRs, even those undetected by phylogeny. When applied to orphan receptor GPR37L1, GPCR-CoINPocket identified its pharmacological neighbors, and transfer of their pharmacology aided in discovery of the first surrogate ligands for this orphan with a 30% success rate. Although primarily designed for GPCRs, the method is easily transferable to other protein families. | 2017 Feb | Nature chemical biology | No DOI | [
{
"LastName": "Ngo",
"FirstName": "Tony",
"Affiliation": "Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia."
},
{
"LastName": "Ilatovskiy",
"FirstName": "Andrey V",
"Affiliation": "Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA."
},
{
"LastName": "Stewart",
"FirstName": "Alastair G",
"Affiliation": "St Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia."
},
{
"LastName": "Coleman",
"FirstName": "James L J",
"Affiliation": "Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia."
},
{
"LastName": "McRobb",
"FirstName": "Fiona M",
"Affiliation": "Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA."
},
{
"LastName": "Riek",
"FirstName": "R Peter",
"Affiliation": "Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia."
},
{
"LastName": "Graham",
"FirstName": "Robert M",
"Affiliation": "Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia."
},
{
"LastName": "Abagyan",
"FirstName": "Ruben",
"Affiliation": "Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA."
},
{
"LastName": "Kufareva",
"FirstName": "Irina",
"Affiliation": "Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA."
},
{
"LastName": "Smith",
"FirstName": "Nicola J",
"Affiliation": "Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia."
}
] | Yes |
32648073 | Factors associated with macular vessel density measured by optical coherence tomography angiography in healthy and glaucomatous eyes. | To investigate factors associated with macular vessel density and to analyze their effects according to glaucoma stage. Retrospective cross-sectional study. A total of 72 healthy eyes and 147 open-angle glaucomatous eyes were studied. All eyes underwent optical coherence tomography and visual field examinations. Clinical variables were compared according to the glaucoma stage. Relationships between macular vessel density (mVD) and other variables were analyzed using linear regression and segmented analyses. Age (P = 0.010) and signal strength (P < 0.001) were associated with macular vessel density in healthy eyes. In glaucomatous eyes, age, signal strength, ganglion cell-inner plexiform layer (GCIPL) thickness, and mean deviation (MD) correlated with macular vessel density (all P ≤ 0.005). When analyzed by glaucoma stage, age correlated with macular vessel density in early (P = 0.017 and all P ≤ 0.012, respectively) and moderate (P = 0.002 and all P ≤ 0.001, respectively) glaucoma. Conversely, GCIPL thickness was associated with macular vessel density (P = 0.004). According to segmented analysis between MD and mVD, the MD value at the change point for mVD was -17.92 dB, which was much lower than that for GCIPL thickness (-5.83 dB). Signal strength was the most significant factor associated with macular vessel density in healthy and glaucomatous eyes. Other than signal strength, factors associated with macular vessel density of glaucomatous eyes vary according to the glaucoma stage. The segmented analysis suggests that mVD could be better than GCIPL thickness in predicting MD changes in moderate-to-advanced glaucoma. | 2020 Sep | Japanese journal of ophthalmology | No DOI | [
{
"LastName": "Lee",
"FirstName": "Kwanghyun",
"Affiliation": "Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea."
},
{
"LastName": "Park",
"FirstName": "Chan Keum",
"Affiliation": "Department of Ophthalmology, Maryknoll Hospital, Busan, South Korea."
},
{
"LastName": "Kim",
"FirstName": "Eun Woo",
"Affiliation": "Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea."
},
{
"LastName": "Kim",
"FirstName": "Joo Yeon",
"Affiliation": "Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea."
},
{
"LastName": "Yang",
"FirstName": "Heon",
"Affiliation": "Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea."
},
{
"LastName": "Choi",
"FirstName": "Wungrak",
"Affiliation": "Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea."
},
{
"LastName": "Lee",
"FirstName": "Sang Yeop",
"Affiliation": "Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea."
},
{
"LastName": "Seong",
"FirstName": "Gong Je",
"Affiliation": "Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea."
},
{
"LastName": "Kim",
"FirstName": "Chan Yun",
"Affiliation": "Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea."
},
{
"LastName": "Bae",
"FirstName": "Hyoung Won",
"Affiliation": "Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. [email protected]."
}
] | No |
33511096 | Mental Health and Coping in the Shadow of the COVID-19 Pandemic: The Israeli Case. | The COVID-19 pandemic caught the entire world off guard. Israel, similar to all other nations, was forced to cope with the unknown. "Flattening the curve" of infections has become a common term among specialists and decision makers, while explaining restricting measurements taken toward the population. Israelis, who had previously learned to deal with life under constant security threat, are now facing a new reality. The purpose of the study was to check how Israelis are psychologically affected by and coping with the COVID-19 pandemic. The study included 925 Israelis divided into three groups: ages 18-29, 30-59, and 60-88. The data were collected between March 31 and April 8, 2020, when it was already clear that this is a global plague, the country's borders were closed, and the government's directive for citizens was to remain at home while imposing limitations on the public and private sectors. The current study examined psychological distress among the three age groups as well as the associations between levels of distress, resilience, and coping strategies. Levels of distress were measured via the BSI-18 that measures anxiety, depression, and somatization. Resilience was measured using the Connor-Davidson CD-RISC scale. Coping was measured by the short version of the COPE. Psychological distress was associated with being in a younger age group, being a woman, having economic concerns, use of emotion and problem focused coping, and lower resilience. The study also found that concern for the health of family members was the strongest concern among all age groups but was highest among the younger age group. It was also found that those in the younger age group suffered from higher levels of depression, anxiety, and somatization compared to the older age group. The middle age group suffered from elevated levels of anxiety and somatization compared to the older age group. Although the older age group was the most vulnerable to the coronavirus, in this study age was found to be a protective factor from psychological distress. The results of the study suggest the need to consider the younger age group as a risk group, which hence needs to be addressed as the focus of intervention programs. It appears that the concern for their loved ones takes a heavy toll on the younger generation, and this should be considered a major source of stress. | 2020 | Frontiers in public health | No DOI | [
{
"LastName": "Shechory Bitton",
"FirstName": "Mally",
"Affiliation": "Department of Criminology, Ariel University, Ariel, Israel."
},
{
"LastName": "Laufer",
"FirstName": "Avital",
"Affiliation": "Behavioral Science, Netanya Academic College, Netanya, Israel."
}
] | No |
32038148 | Physical Activity Induces Nucleus Accumbens Genes Expression Changes Preventing Chronic Pain Susceptibility Promoted by High-Fat Diet and Sedentary Behavior in Mice. | Recent findings from rodent studies suggest that high-fat diet (HFD) increases hyperalgesia independent of obesity status. Furthermore, weight loss interventions such as voluntary physical activity (PA) for adults with obesity or overweight was reported to promote pain reduction in humans with chronic pain. However, regardless of obesity status, it is not known whether HFD intake and sedentary (SED) behavior is underlies chronic pain susceptibility. Moreover, differential gene expression in the nucleus accumbens (NAc) plays a crucial role in chronic pain susceptibility. Thus, the present study used an adapted model of the inflammatory prostaglandin E2 (PGE2)-induced persistent hyperalgesia short-term (PH-ST) protocol for mice, an HFD, and a voluntary PA paradigm to test these hypotheses. Therefore, we performed an analysis of differential gene expression using a transcriptome approach of the NAc. We also applied a gene ontology enrichment tools to identify biological processes associated with chronic pain susceptibility and to investigate the interaction between the factors studied: diet (standard diet vs. HFD), physical activity behavior (SED vs. PA) and PH-ST (PGE vs. saline). Our results demonstrated that HFD intake and sedentary behavior promoted chronic pain susceptibility, which in turn was prevented by voluntary physical activity, even when the animals were fed an HFD. The transcriptome of the NAc found 2,204 differential expression genes and gene ontology enrichment analysis revealed 41 biologic processes implicated in chronic pain susceptibility. Taking these biological processes together, our results suggest that genes related to metabolic and mitochondria stress were up-regulated in the chronic pain susceptibility group (SED-HFD-PGE), whereas genes related to neuroplasticity were up-regulated in the non-chronic pain susceptibility group (PA-HFD-PGE). These findings provide pieces of evidence that HFD intake and sedentary behavior provoked gene expression changes in the NAc related to promotion of chronic pain susceptibility, whereas voluntary physical activity provoked gene expression changes in the NAc related to prevention of chronic pain susceptibility. Finally, our findings confirmed previous literature supporting the crucial role of voluntary physical activity to prevent chronic pain and suggest that low levels of voluntary physical activity would be helpful and highly recommended as a complementary treatment for those with chronic pain. | 2019 | Frontiers in neuroscience | No DOI | [
{
"LastName": "Brandão",
"FirstName": "Arthur Freitas",
"Affiliation": "Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil."
},
{
"LastName": "Bonet",
"FirstName": "Ivan José Magayewski",
"Affiliation": "Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil."
},
{
"LastName": "Pagliusi",
"FirstName": "Marco",
"Affiliation": "Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil."
},
{
"LastName": "Zanetti",
"FirstName": "Gabriel Gerardini",
"Affiliation": "Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil."
},
{
"LastName": "Pho",
"FirstName": "Nam",
"Affiliation": "eScience Institute, University of Washington, Seattle, WA, United States."
},
{
"LastName": "Tambeli",
"FirstName": "Cláudia Herrera",
"Affiliation": "Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil."
},
{
"LastName": "Parada",
"FirstName": "Carlos Amilcar",
"Affiliation": "Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil."
},
{
"LastName": "Vieira",
"FirstName": "André Schwambach",
"Affiliation": "Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil."
},
{
"LastName": "Sartori",
"FirstName": "Cesar Renato",
"Affiliation": "Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil."
}
] | No |
16233474 | Characterization of a class III chitinase from Vitis vinifera cv. Koshu. | A chitinase gene (Chi3K) was cloned from the genomic DNA of Vitis vinifera cv. Koshu. The structural gene comprised 891 by without introns and encoded 297 amino acids. The Chi3K product showed high similarity to the class III chitinase of V. vinifera cv. Pinot noir. Chi3K was expressed using a bacterial expression vector for purification and enzymatic characterization of its gene product. The recombinant chitinase exhibited hydrolytic activity toward glycol chitin and its optimum pH was 4.0. It also inhibited the growth of Botrytis cinerea, which causes grey mold disease in grapes. | 2003 | Journal of bioscience and bioengineering | No DOI | [
{
"LastName": "Ano",
"FirstName": "Akihiko",
"Affiliation": "The Institute of Enology and Viticulture, Yamanashi University, 1-13-1 Kitashin, Kofu 400-0005, Japan."
},
{
"LastName": "Takayanagi",
"FirstName": "Tsutomu",
"Affiliation": ""
},
{
"LastName": "Uchibori",
"FirstName": "Takayuki",
"Affiliation": ""
},
{
"LastName": "Okuda",
"FirstName": "Tohru",
"Affiliation": ""
},
{
"LastName": "Yokotsuka",
"FirstName": "Koki",
"Affiliation": ""
}
] | No |
33605251 | Care of Non COVID Patients in COVID-19 Era. | The consequences of the COVID-19 pandemic are extensive and far-reaching. Non COVID communicable diseases continue to spread and non-communicable diseases continue to progress. People may access healthcare facilities little bit late due to fear of contracting COVID-19 and present with severe symptoms, even with complications. Nepal has been facing dual burden of both non-communicable and communicable diseases. The number of COVID-19 patients has continuously been rising in Nepal since the start of May 2020. There is an anticipated surge of infectious disease such as malaria, dengue fever, enteric fever, scrub typhus, leptospirosis during summer and monsoon seasons in Nepal. There will be surge of cases of acute undifferentiated febrile illness (AUFI) during monsoon. As fever is one of the very common symptoms of COVID-19, so COVID-19 needs to be considered in differential diagnoses of acute undifferentiated febrile illness. | 2020 COVID-19 SPECIAL ISSUE | Kathmandu University medical journal (KUMJ) | No DOI | [
{
"LastName": "Piryani",
"FirstName": "S",
"Affiliation": "Public Health Consultant, Karachi, Pakistan."
},
{
"LastName": "Piryani",
"FirstName": "R M",
"Affiliation": "Department of Internal Medicine, Universal College of Medical Sciences, Bhairahawa, Nepal."
},
{
"LastName": "Dangal",
"FirstName": "G",
"Affiliation": "Department of Obstetrics and Gynecology, Kathmandu Model Hospital, kathmandu, Nepal."
}
] | No |
39035773 | Healthcare Professionals' Attitude to Using Mobile Health Technology and Its Associated Factors in a Resource-Limited Country-An Implication for Digital Health Implementers: A Cross Sectional Study. | Background: Mobile health has become widely used within the healthcare system, and there is an increasing worldwide trend toward employing this innovation for behavior management, disease monitoring, the control and prevention of various health issues, and rising enrollment in healthcare services. Although mHealth is becoming more widely available, there is no evidence about the attitude of healthcare professionals toward mHealth in southwest Ethiopia. Therefore, this study is aimed at assessing the attitude of healthcare professionals to using mHealth technology and associated factors in Ethiopia. Methods: An institutional cross-sectional study was conducted among 422 healthcare professionals. Data were collected using a pretested interviewer-administered questionnaire, and the study was conducted from January 08 to February 10, 2023. EpiData Version 4.6 for entering the data and STATA Version 14 for analyzing the data were used. A multivariable logistic regression analysis was carried out to identify factors associated with healthcare professionals' attitudes to using mobile health technology. Results: A total of 415 study participants were included in the study. About 180 (43.4%) respondents had a favorable attitude toward mHealth technology in southwest public hospitals. Master's degree and above (adjusted odds ratio [AOR]: 3.67; 95% CI: 1.22, 4.10), good knowledge of mobile health technology (AOR: 4.08; 95% CI: 1.35, 5.31), more than 5 years of work experience (AOR: 3.09; 95% CI: 1.76, 5.60), had ICT infrastructure (AOR: 2.70; 95% CI: 1.38, 5.31), had own smart mobile (AOR: 3.67; 95% CI: 3.20, 4.31), and had taken computer-related training (AOR: 1.96; 95% CI: 1.03, 3.73) were positively associated with healthcare professionals' attitude to using mobile health technologies in southwest Ethiopia. Conclusions: Overall, healthcare professionals' attitude to using mobile health technologies in southwest Ethiopia was relatively low. Education level, good knowledge, years of work experience, ICT infrastructure, having a smart mobile, and having taken computer-related training were significant factors of attitude to using mobile health technologies. Considering these factors could provide insight into developing and adopting mobile health technologies in Ethiopia. | 2024 | BioMed research international | No DOI | [
{
"LastName": "Walle",
"FirstName": "Agmasie Damtew",
"Affiliation": "Department of Health Informatics School of Public Health Asrat Woldeyes Health Science Campus Debre Berhan University, Debre Birhan, Ethiopia."
},
{
"LastName": "Butta",
"FirstName": "Fikadu Wake",
"Affiliation": "Department of Health Informatics College of Health Science Mattu University, Metu, Ethiopia."
},
{
"LastName": "Kassie",
"FirstName": "Sisay Yitayih",
"Affiliation": "Department of Health Informatics School of Public Health Hawassa University, Hawassa, Ethiopia."
},
{
"LastName": "Chereka",
"FirstName": "Alex Ayenew",
"Affiliation": "Department of Health Informatics College of Health Science Mattu University, Metu, Ethiopia."
},
{
"LastName": "Kanfe",
"FirstName": "Shuma Gosha",
"Affiliation": "Department of Health Informatics College of Health Science Mattu University, Metu, Ethiopia."
},
{
"LastName": "Dubale",
"FirstName": "Abiy Tasew",
"Affiliation": "Department of Health Informatics College of Health Science Mattu University, Metu, Ethiopia."
},
{
"LastName": "Enyew",
"FirstName": "Ermias Bekele",
"Affiliation": "Department of Health Informatics School of Public Health College of Health Science Wollo University, Dessie, Ethiopia."
},
{
"LastName": "Dube",
"FirstName": "Geleta Nenko",
"Affiliation": "Department of Health Informatics College of Health Science Mattu University, Metu, Ethiopia."
},
{
"LastName": "Shibabaw",
"FirstName": "Adamu Ambachew",
"Affiliation": "Department of Health Informatics College of Health Science Mattu University, Metu, Ethiopia."
},
{
"LastName": "Hunde",
"FirstName": "Mekonnen Kenate",
"Affiliation": "Department of Lifelong Learning and Community Development College of Education and Behavioral Science Mattu University, Metu, Ethiopia."
},
{
"LastName": "Kitil",
"FirstName": "Gemeda Wakgari",
"Affiliation": "Department of Midwifery College of Health Science Mettu University, Metu, Ethiopia."
},
{
"LastName": "Ferede",
"FirstName": "Tigist Andargie",
"Affiliation": "Department of Epidemiology Institute of Public Health College of Medicine and Health Science University of Gondar, Gondar, Ethiopia."
},
{
"LastName": "Wubante",
"FirstName": "Sisay Maru",
"Affiliation": "Department of Health Informatics Institute of Public Health College of Medicine and Health Science University of Gondar, Gondar, Ethiopia."
},
{
"LastName": "Baykemagn",
"FirstName": "Nebebe Demis",
"Affiliation": "Department of Health Informatics Institute of Public Health College of Medicine and Health Science University of Gondar, Gondar, Ethiopia."
},
{
"LastName": "Demsash",
"FirstName": "Addisalem Workie",
"Affiliation": "Department of Health Informatics School of Public Health Asrat Woldeyes Health Science Campus Debre Berhan University, Debre Birhan, Ethiopia."
}
] | No |
29746216 | Digital Ethnography of Zoophilia - A Multinational Mixed-Methods Study. | This study investigates people who have sex with animals (PSA) by describing their living situation, sexual activity, beliefs, and attitudes toward stigmatization. These data are highly applicable to the work of psychiatric and forensic professionals investigating paraphilias. We apply mixed-methods approach, using qualitative and quantitative analyses. The findings come from anonymous forum postings of 953 participants; of which 345 agreed to complete a survey upon advertising the study. We identify several themes, describing concerns of zoosexuals chatting within online communities: living situation; sex life; social acceptability; getting help. First, we provide data on how PSA justify their relationships with animal sex partners - with particular emphasis on sex practices and physical features most attractive to them. Second, we elaborate on the stigma associated with being a zoosexual, including the coping mechanism for dealing with social ostracism. Third, we elaborate, in detail, on why PSA find animals sexually appealing. Lastly, we present evidence that online discussion spaces serve as the platform for help-seeking behavior for individuals with paraphilias. This study presents the largest analyses of zoophiles in modern history, using mixed-methods approach, uncovering their daily activities, sexual preferences, and help-seeking behavior. | 2019 | Journal of sex & marital therapy | No DOI | [
{
"LastName": "Sendler",
"FirstName": "Damian Jacob",
"Affiliation": "a Laboratory of Forensic Sexology, Legal Medicine, and Digital Ethnography , Felnett Health Research Foundation , Staten Island , New York , USA."
},
{
"LastName": "Lew-Starowicz",
"FirstName": "Michal",
"Affiliation": "b Department of Psychiatry , Institute of Psychiatry and Neurology , Warsaw , Poland."
}
] | Yes |
38457142 | Detection of hepatocellular carcinoma methylation markers in salivary DNA. | Alterations to DNA methylation have been identified in both hepatocellular carcinoma (HCC) tumor and circulating DNA from affected individuals. These markers have potential utility in HCC screening. Adherence to HCC screening is poor and acceptable HCC screening tests are needed. A feasibility study was performed on a subset of case patients and control subjects from a prior study of risk factors for HCC. Case patients (n=12) included adults aged 47-85 years with a first diagnosis of HCC between 2011 and 2016 and without viral hepatitis. Control subjects (n=12) were matched on age, sex, and state of residence. Participants provided saliva samples for DNA genotyping. Log fold change in salivary DNA methylation at 1359 CpG sites representing 25 candidate genes previously associated with HCC was compared across case patients and control subjects. The quantity of DNA ranged from 9.65 to 257.79 μg. The purity of DNA isolates was good, with mean OD260/280 ratio of 1.78 (SD: 0.14). Of 25 candidate genes, 16 had at ≥1 CpG site with detectable differences in methylation across HCC case patients and control subjects. Sites differentially methylated in HCC case patients included genes encoding tumor suppressors (PRDM2, RUNX3, p15/16, and RASSF1/5), regulators of cell cycle progression (DAPK1 and TP73), and DNA repair (MGMT and GSTP1). No associations met the significance threshold 3.7 × 10-5 required for multiple comparisons. Salivary DNA may be a feasible alternative to blood samples in the era of novel DNA-based screening tests for HCC. The ease of saliva-based testing supports further investigation of its potential. | 2024 Mar 29 | Bioscience reports | No DOI | [
{
"LastName": "Mezzacappa",
"FirstName": "Catherine",
"Affiliation": "Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States."
},
{
"LastName": "Wang",
"FirstName": "Zhanwei",
"Affiliation": "University of Hawai'i Cancer Consortium, Honolulu, HI, United States."
},
{
"LastName": "Lu",
"FirstName": "Lingeng",
"Affiliation": "Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, United States."
},
{
"LastName": "Risch",
"FirstName": "Harvey",
"Affiliation": "Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, United States."
},
{
"LastName": "Taddei",
"FirstName": "Tamar",
"Affiliation": "Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States."
},
{
"LastName": "Yu",
"FirstName": "Herbert",
"Affiliation": "University of Hawai'i Cancer Consortium, Honolulu, HI, United States."
}
] | No |
35178122 | Quantifying Region-Specific Elastic Properties of Distal Femoral Articular Cartilage: A Shear-Wave Elastography Study. | Knee osteoarthritis is a disease with the degeneration of articular cartilage as its main feature. Cartilage thickness cannot become a single index to evaluate cartilage degeneration, so it is essential to also evaluate the stiffness. The purposes were as follows: (1) to examine test-retest reliabilities of the elastic modulus measurement in distal femoral articular cartilage (FAC) and compare the changes in specific-regional of distal FAC, (2) to explore the difference in distal FAC stiffness and thickness between the dominant and nondominant sides, and (3) to examine the correlation between the elastic properties of cartilage and the thickness of cartilage. Twenty healthy participants were recruited. The stiffness of distal FAC at the lateral femoral condyle (LFC), medial femoral condyle (MFC), and intercondylar notch (IN) was quantified using shear-wave elastography (SWE). Intra- and interrater reliabilities were excellent for measuring the stiffness of distal FAC (ICC: 0.83-0.98). About a 50% increase in the stiffness of LFC (40.78 kPa) was found when compared with IN (21.82 kPa) and MFC (18.34 kPa). No significant difference was found between the dominant and nondominant sides in distal FAC stiffness and thickness. There was no correlation between the stiffness and thickness of the distal FAC. In conclusion, SWE can quantify the stiffness of the distal FAC. | 2022 | Applied bionics and biomechanics | No DOI | [
{
"LastName": "Deng",
"FirstName": "Weixin",
"Affiliation": "Clinical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China."
},
{
"LastName": "Lin",
"FirstName": "Ming",
"Affiliation": "Clinical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China."
},
{
"LastName": "Yu",
"FirstName": "Suiqing",
"Affiliation": "Clinical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China."
},
{
"LastName": "Liang",
"FirstName": "Hongying",
"Affiliation": "Clinical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China."
},
{
"LastName": "Zhang",
"FirstName": "Zhijie",
"Affiliation": "Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, China."
},
{
"LastName": "Liu",
"FirstName": "Chunlong",
"Affiliation": "Clinical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China."
}
] | No |
35736875 | Magnetic Susceptibility Source Separation Solely from Gradient Echo Data: Histological Validation. | Quantitative susceptibility mapping (QSM) facilitates mapping of the bulk magnetic susceptibility of tissue from the phase of complex gradient echo (GRE) MRI data. QSM phase processing combined with an R2* model of magnitude of multiecho gradient echo data (R2*QSM) allows separation of dia- and para-magnetic components (e.g., myelin and iron) that contribute constructively to R2* value but destructively to the QSM value of a voxel. This R2*QSM technique is validated against quantitative histology—optical density of myelin basic protein and Perls’ iron histological stains of rim and core of 10 ex vivo multiple sclerosis lesions, as well as neighboring normal appearing white matter. We found that R2*QSM source maps are in good qualitative agreement with histology, e.g., showing increased iron concentration at the edge of the rim+ lesions and myelin loss in the lesions’ core. Furthermore, our results indicate statistically significant correlation between paramagnetic and diamagnetic tissue components estimated with R2*QSM and optical densities of Perls’ and MPB stains. These findings provide direct support for the use of R2*QSM magnetic source separation based solely on GRE complex data to characterize MS lesion composition. | 2022 Jun 14 | Tomography (Ann Arbor, Mich.) | No DOI | [
{
"LastName": "Dimov",
"FirstName": "Alexey V",
"Affiliation": "Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA."
},
{
"LastName": "Gillen",
"FirstName": "Kelly M",
"Affiliation": "Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA."
},
{
"LastName": "Nguyen",
"FirstName": "Thanh D",
"Affiliation": "Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA."
},
{
"LastName": "Kang",
"FirstName": "Jerry",
"Affiliation": "Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA."
},
{
"LastName": "Sharma",
"FirstName": "Ria",
"Affiliation": "Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA."
},
{
"LastName": "Pitt",
"FirstName": "David",
"Affiliation": "Department of Neurology, Yale Medicine, New Haven, CT 06511, USA."
},
{
"LastName": "Gauthier",
"FirstName": "Susan A",
"Affiliation": "Department of Neurology, Weill Cornell Medicine, New York, NY 10022, USA."
},
{
"LastName": "Wang",
"FirstName": "Yi",
"Affiliation": "Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA."
}
] | No |
17271374 | Applications of vibrotactile display of body tilt for rehabilitation. | Body-mounted motion sensors have been shown to decrease subject sway when a tilt estimate is fed back to the user by means of an array of tactile vibrators which display estimated tilt magnitude and direction. Vestibulopathic subjects who are tested using computerized dynamic posturography show significantly reduced sway in both the sensory motor and the motor control portions of that test. This result suggests potential application as an assistive balance aid. Another potential application of vibrotactile tilt feedback is in rehabilitation. Two lines of research have yielded promising, albeit very preliminary, supporting results. The first of these is the response of subjects to a toes-up pitch maneuver. At critical pitch velocities, vestibulopathic subjects are unable to maintain stability during or after a perturbation without tilt feedback, but are able to stand when feedback is provided. The second line of research involves perturbations during locomotion. Vibrotactile tilt feedback again reduces subjects sway. Preliminary results of both of these on-going experiments indicate that this increase in performance may be retained. | 2004 | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference | No DOI | [
{
"LastName": "Wall",
"FirstName": "C",
"Affiliation": "Harvard Medical School, Boston, MA, USA."
},
{
"LastName": "Oddsson",
"FirstName": "L E",
"Affiliation": ""
},
{
"LastName": "Horak",
"FirstName": "F B",
"Affiliation": ""
},
{
"LastName": "Wrisley",
"FirstName": "D W",
"Affiliation": ""
},
{
"LastName": "Dozza",
"FirstName": "M",
"Affiliation": ""
}
] | No |
19090306 | Determination of carbon/nitrogen ratio and heavy metals in bulking agents used for sewage composting. | Improving the soil quality with organic matter and N, P and K contents are some of sewage sludge benefits. Adjusting carbonaceous materials such as plant wastes to dewatered sludge compost results in increasing the moisture content and improving C/N ratio. This study was conduced for three months in 2005, in Laboratory of Chemistry of Water and Wastewater in the School of Public Health of Isfahan University of Medical Science, to determine the C/N ratio and heavy metals concentration of bulking agents in sawdust, leaves, rice hulls and dewatered sewage sludge. Dewatered sludge was collected from Isfahan sewage treatment plant. Sawdust was collected from sawmills. Leaves were collected from municipality of Isfahan and rice hull from rice mills, then in samples determined C/N ratio and heavy metal according to standard methods. The results showed that concentrations of chromium and cadmium in the mixture of dewatered sewage sludge and bulking agents were lower them those of the standard level. Means of cobalt (115.44 mg kg(-1)), nickel (57.44 mg kg(-1)) and zinc (273.48 mg kg(-1)) concentrations were maximum in dewatered sludge but mean concentration of cobalt (25.66 mg kg(-1)) in rice hull samples and mean zinc (8.99 mg kg(-1)) and nickel (5.106 mg kg(-1)) concentrations in sawdust samples were minimum. The optimal conditions sewage sludge composting, each kilogram of sludge needs 350 g of saw dust, 470 g of leaves and 388 g of rice hull. Amount of heavy metals present in the bulking agents is lower than the amount mentioned for the compost. | 2007 Nov 15 | Pakistan journal of biological sciences : PJBS | No DOI | [
{
"LastName": "Alidadi",
"FirstName": "H",
"Affiliation": "Department of Environmental Health, Faculty of Health, Mashhad University of Medical Sciences, Iran."
},
{
"LastName": "Najafpoor",
"FirstName": "A A",
"Affiliation": ""
},
{
"LastName": "Parvaresh",
"FirstName": "A",
"Affiliation": ""
}
] | No |
28381173 | Mesothelin-targeting chimeric antigen receptor-modified T cells by piggyBac transposon system suppress the growth of bile duct carcinoma. | Chimeric antigen receptor modified T cell-based immunotherapy is revolutionizing the field of cancer treatment. However, its potential in treating bile duct carcinoma has not been fully explored. Herein, we developed the second-generation mesothelin-targeting chimeric antigen receptor-modified T cells with the 4-1BB co-stimulatory module by the piggyBac transposon system. Mesothelin-targeting chimeric antigen receptor was expressed by 66.0% of mesothelin-targeting chimeric antigen receptor-modified T cells post electrophoretic transfection and stimulation with K562-meso cells; the expressions of activation markers were tested by flow cytometry assay and showed greater activation of mesothelin-targeting chimeric antigen receptor-modified T cells than control T cells (CD107α: 71.9% vs 48.6%; CD27: 92.1% vs 61.8%; CD137: 55.5% vs 8.4%; CD28: 98.0% vs 82.1%; CD134: 37.5% vs 10.4%). Furthermore, mesothelin-targeting chimeric antigen receptor-modified T cells exerted cytotoxicity toward mesothelin-expressing EH-CA1b and EH-CA1a cells in an effector-to-target ratio-dependent manner, while leaving mesothelin-negative GSC-SD and EH-GB1 cells and normal liver L02 cells almost unharmed. Mesothelin-targeting chimeric antigen receptor-modified T cells secreted cytokines at higher levels when co-cultured with mesothelin-positive EH-CA1a and EH-CA1b cells than with mesothelin-negative GSC-SD and EH-GB1 cells. Enhanced cytotoxicity and cytokine secretion of mesothelin-targeting chimeric antigen receptor-modified T cells compared to control T cells were also observed when co-cultured with 293-meso cells (interferon γ: 85.1% ± 1.47% vs 8.3% ± 2.50%, p = 0.000; tumor necrosis factor α: 90.9% ± 4.67% vs 18.5% ± 3.62%, p = 0.0004; interleukin 2: 60.8% ± 2.00% vs 15.6% ± 2.06%, p = 0.002; interleukin 6: 6.4% ± 2.95% vs 1.7% ± 0.63%, p = 0.055). In addition, mesothelin-targeting chimeric antigen receptor-modified T cells showed greater inhibitory and proliferative capability than control T cells within EH-CA1a cell xenografts. This study shows the potential of mesothelin-targeting chimeric antigen receptor-modified T cells in treating bile duct carcinoma. | 2017 Apr | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | No DOI | [
{
"LastName": "Xu",
"FirstName": "Jie-Ying",
"Affiliation": "1 Xinyuan Institute of Medicine and Biotechnology, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China."
},
{
"LastName": "Ye",
"FirstName": "Zhen-Long",
"Affiliation": "2 Laboratory of Gene and Viral Therapy, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University of Chinese PLA, Shanghai, China."
},
{
"LastName": "Jiang",
"FirstName": "Du-Qing",
"Affiliation": "1 Xinyuan Institute of Medicine and Biotechnology, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China."
},
{
"LastName": "He",
"FirstName": "Jiang-Chuan",
"Affiliation": "1 Xinyuan Institute of Medicine and Biotechnology, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China."
},
{
"LastName": "Ding",
"FirstName": "Yong-Mei",
"Affiliation": "3 Department of Biotherapy, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University of Chinese PLA, Shanghai, China."
},
{
"LastName": "Li",
"FirstName": "Lin-Fang",
"Affiliation": "2 Laboratory of Gene and Viral Therapy, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University of Chinese PLA, Shanghai, China."
},
{
"LastName": "Lv",
"FirstName": "Sai-Qun",
"Affiliation": "2 Laboratory of Gene and Viral Therapy, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University of Chinese PLA, Shanghai, China."
},
{
"LastName": "Wang",
"FirstName": "Ying",
"Affiliation": "2 Laboratory of Gene and Viral Therapy, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University of Chinese PLA, Shanghai, China."
},
{
"LastName": "Jin",
"FirstName": "Hua-Jun",
"Affiliation": "2 Laboratory of Gene and Viral Therapy, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University of Chinese PLA, Shanghai, China."
},
{
"LastName": "Qian",
"FirstName": "Qi-Jun",
"Affiliation": "1 Xinyuan Institute of Medicine and Biotechnology, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China."
}
] | No |
10698946 | Transcription-dependent R-loop formation at mammalian class switch sequences. | Immunoglobulin class switching is mediated by recombination between switch sequences located immediately upstream of the immunoglobulin constant heavy chain genes. Targeting of recombination to particular switch sequences is associated temporally with transcription through these regions. We recently have provided evidence for inducible and stable RNA-DNA hybrid formation at switch sequences in the mouse genome that are mechanistically important for class switching in vivo. Here, we define in vitro the precise configuration of the DNA and RNA strands within this hybrid structure at the Smicro, Sgamma3 and Sgamma2b mouse switch sequences. We find that the G-rich (non-template) DNA strand of each switch sequence is hypersensitive to probes throughout much of its length, while the C-rich (template) DNA strand is essentially resistant. These results demonstrate formation of an R-loop, whereby the G-rich RNA strand forms a stable heteroduplex with its C-rich DNA strand counterpart, and the G-rich DNA strand exists primarily in a single-stranded state. We propose that the organized structure of the R-loop is essential for targeting the class switch recombination machinery to these sequences. | 2000 Mar 1 | The EMBO journal | No DOI | [
{
"LastName": "Tracy",
"FirstName": "R B",
"Affiliation": "Department of Pathology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA."
},
{
"LastName": "Lieber",
"FirstName": "M R",
"Affiliation": ""
}
] | Yes |
31998076 | Acute Liver Failure Induces Glial Reactivity, Oxidative Stress and Impairs Brain Energy Metabolism in Rats. | Acute liver failure (ALF) implies a severe and rapid liver dysfunction that leads to impaired liver metabolism and hepatic encephalopathy (HE). Recent studies have suggested that several brain alterations such as astrocytic dysfunction and energy metabolism impairment may synergistically interact, playing a role in the development of HE. The purpose of the present study is to investigate early alterations in redox status, energy metabolism and astrocytic reactivity of rats submitted to ALF. Adult male Wistar rats were submitted either to subtotal hepatectomy (92% of liver mass) or sham operation to induce ALF. Twenty-four hours after the surgery, animals with ALF presented higher plasmatic levels of ammonia, lactate, ALT and AST and lower levels of glucose than the animals in the sham group. Animals with ALF presented several astrocytic morphological alterations indicating astrocytic reactivity. The ALF group also presented higher mitochondrial oxygen consumption, higher enzymatic activity and higher ATP levels in the brain (frontoparietal cortex). Moreover, ALF induced an increase in glutamate oxidation concomitant with a decrease in glucose and lactate oxidation. The increase in brain energy metabolism caused by astrocytic reactivity resulted in augmented levels of reactive oxygen species (ROS) and Poly [ADP-ribose] polymerase 1 (PARP1) and a decreased activity of the enzymes superoxide dismutase and glutathione peroxidase (GSH-Px). These findings suggest that in the early stages of ALF the brain presents a hypermetabolic state, oxidative stress and astrocytic reactivity, which could be in part sustained by an increase in mitochondrial oxidation of glutamate. | 2019 | Frontiers in molecular neuroscience | No DOI | [
{
"LastName": "Guazzelli",
"FirstName": "Pedro Arend",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "Cittolin-Santos",
"FirstName": "Giordano Fabricio",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "Meira-Martins",
"FirstName": "Leo Anderson",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "Grings",
"FirstName": "Mateus",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "Nonose",
"FirstName": "Yasmine",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "Lazzarotto",
"FirstName": "Gabriel S",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "Nogara",
"FirstName": "Daniela",
"Affiliation": "Department of Biochemistry, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "da Silva",
"FirstName": "Jussemara S",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "Fontella",
"FirstName": "Fernanda U",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "Wajner",
"FirstName": "Moacir",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "Leipnitz",
"FirstName": "Guilhian",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "Souza",
"FirstName": "Diogo O",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
},
{
"LastName": "de Assis",
"FirstName": "Adriano Martimbianco",
"Affiliation": "Post-graduate Program in Biological Sciences: Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil."
}
] | No |
18968615 | Practical aspects of routine trace element environmental analysis by inductively coupled plasma-mass spectrometry. | Since the appearance, in the early eighties, of first publications describing plasma source mass spectrometry as a viable analytical technique, there has been a rapid increase in the number of papers detailing its possible applications, instrumental developments and fundamental studies. In the laboratories involved in the environmental or food monitoring problematics, inductively coupled plasma-mass spectrometry (ICP-MS) systems are usually acquired in order to analyze large series of samples. At our knowledge, very rare are works dedicated to the sum of factors and additional problems usually encountered in the routine analysis using this analytical technique. In this work, we will try to fill in these gaps by discussing the main factors that may strongly influence the analysis of large series of samples. Firstly, there are uncertainties associated to the choice of measurement parameters: calibration blanks, curve algorithms and their long-term validity, selection of internal standards, recalibration blocks and usefulness of correction equations. Secondly, we will discuss analytical parameters that concern samples themselves: their appropriate dilution and acidification as well as the knowledge of matrix effects possibly produced. Finally, there is also a very important point concerning appropriate definition of the procedure blank as well as its utilization. Only the careful consideration of all these aspects permits to obtain accurate results during routine analysis. Aim of this work is not oriented to discussion of typical and well-documented ICP-MS individual problems but rather to means that allow to overcome main uncertainties resulting in an improvement of the whole routine analysis. | 2002 Apr 22 | Talanta | No DOI | [
{
"LastName": "Salomon",
"FirstName": "Stéphanie",
"Affiliation": "Centre for Veterinary and Agrochemical Research (CERVA), Leuvensesteenweg 17, B-3080 Tervuren, Belgium."
},
{
"LastName": "Jenne",
"FirstName": "Valérie",
"Affiliation": ""
},
{
"LastName": "Hoenig",
"FirstName": "Michel",
"Affiliation": ""
}
] | No |
35211189 | Renoprotective Effect of Intraoperative Dexmedetomidine in Renal Transplantation. | Renal dysfunction after kidney transplantation may be influenced by many reasons. This study was designed to evaluate whether the administration of dexmedetomidine (Dex) could ameliorate renal function and prognosis after kidney transplantation. A total of 65 patients were divided into Dex group (n = 33) and Con group (Con, n = 32). Dex group intravenously received an initial loading dose of 0.6 μg/kg Dex for 15 min before anaesthesia induction, followed by a rate of 0.4 μg/kg/h until 30 min after kidney reperfusion. By contrast, Con group received saline. The concentration of urinary kidney injury molecule-1 (KIM-1), serum creatinine (Cr), blood urea, urine output, β2 microglobulin (β2-MG), Cystatin C (CysC), and estimated glomerular filtration rate (eGFR) was recorded and compared between two groups during the course of the hospitalization or follow-up. Mean arterial pressure (MAP) and heart rate (HR), vasoactive drugs, and anaesthetics were recorded during the operation. Pain degree was evaluated using a visual analogue scale (VAS) after operation. Delayed graft function (DGF), graft loss, length of hospital stay, and mortality were compared between groups. The concentration of KIM-1 in Dex group was lower than Con group at 2 h (P = 0.018), 24 h (P = 0.013), 48 h (P < 0.01), and 72 h (P < 0.01) after reperfusion. MAP of Dex group after tracheal intubation (P = 0.012) and incision (P = 0.018) and HR after intubation (P = 0.021) were lower than that of Con group. The dosage of sufentanil during operation in Dex group was less than Con group (P = 0.039). Patients that used atropine in Dex group were more than Con group (P = 0.027). Patients who received Dex presented with lower VAS scores at 6 h (P = 0.01) and 12 h (P = 0.002) after operation. Concentration of serum Cr and blood urea had no significant differences between groups before operation and on postoperative day 1 to 6. Urine output was recorded for 6 days after operation and had no differences between groups. Also, no differences were identified between two groups in urea, Cr, β2-MG, CysC, and eGFR in the first 3 months after operation. Incidence of DGF after operation was detected no difference between groups, while length of hospital stay in Dex group was less than Con group (P = 0.012). Dex can decrease kidney injury marker level, attenuate perioperative stress, relieve the dosage of sufentanil and postoperative pain, and reduce length of hospital stay. However, Dex is not associated with changes in prognosis in the first 3 months after transplantation. | 2022 | Computational and mathematical methods in medicine | No DOI | [
{
"LastName": "Liu",
"FirstName": "Zhenzhen",
"Affiliation": "Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Jin",
"FirstName": "Yanwu",
"Affiliation": "Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Feng",
"FirstName": "Chang",
"Affiliation": "Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Liu",
"FirstName": "Ge",
"Affiliation": "Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Wang",
"FirstName": "Yinghui",
"Affiliation": "Department of Nephrology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Zhao",
"FirstName": "Xin",
"Affiliation": "Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China."
},
{
"LastName": "Liu",
"FirstName": "Gang",
"Affiliation": "Department of Nephrology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China."
}
] | Yes |
32594856 | Aggregability of β(1→4)-linked glucosaminoglucan originating from a sulfur-oxidizing bacterium Thiothrix nivea. | β-1,4-glucosaminoglucan (GG) was prepared from the sheath of a sulfur-oxidizing bacterium Thiothrix nivea. Recently, GG was found to be adsorbed by cellulose (paper) and is therefore potentially applicable as an aminating agent for cellulose. We attempted to increase the yield of GG using a fed-batch cultivation method. Furthermore, the behavior of GG molecules in water was theoretically and experimentally investigated. NMR analysis in combination with molecular dynamics calculation suggested that GG molecules tend to form soluble aggregates in water. It was experimentally revealed that the self-aggregation is enhanced by the addition of NaCl and reduced temperature. Adsorption of GG onto cellulose via hydrogen bonding was confirmed by molecular dynamics simulation. Adsorption was also promoted in the presence of NaCl but was inhibited by a reduction in temperature. Only 11% of the amino groups in the GG-treated paper was reactive, suggesting that GG molecules adsorbed by the paper were forming aggregates. | 2020 Oct | Bioscience, biotechnology, and biochemistry | No DOI | [
{
"LastName": "Takeda",
"FirstName": "Minoru",
"Affiliation": "Graduate School of Engineering, Yokohama National University , Yokohama, Japan."
},
{
"LastName": "Kondo",
"FirstName": "Keiko",
"Affiliation": "Institute of Advanced Energy, Kyoto University , Kyoto, Japan."
},
{
"LastName": "Tominaga",
"FirstName": "Ryo",
"Affiliation": "Graduate School of Engineering, Yokohama National University , Yokohama, Japan."
},
{
"LastName": "Mori",
"FirstName": "Honomi",
"Affiliation": "Graduate School of Engineering, Yokohama National University , Yokohama, Japan."
},
{
"LastName": "Kato",
"FirstName": "Mana",
"Affiliation": "Graduate School of Engineering, Yokohama National University , Yokohama, Japan."
},
{
"LastName": "Usami",
"FirstName": "Ryoji",
"Affiliation": "Graduate School of Engineering, Yokohama National University , Yokohama, Japan."
},
{
"LastName": "Murakami",
"FirstName": "Tomoi",
"Affiliation": "Graduate School of Engineering, Yokohama National University , Yokohama, Japan."
},
{
"LastName": "Ueda",
"FirstName": "Kazuyoshi",
"Affiliation": "Graduate School of Engineering, Yokohama National University , Yokohama, Japan."
},
{
"LastName": "Suzuki",
"FirstName": "Ichiro",
"Affiliation": "Graduate School of Engineering, Yokohama National University , Yokohama, Japan."
},
{
"LastName": "Katahira",
"FirstName": "Masato",
"Affiliation": "Institute of Advanced Energy, Kyoto University , Kyoto, Japan."
}
] | No |
25280027 | Changes in extra- and intracellular pH in hepatocytes exposed to gabexate mesilate. | Gabexate mesilate (GM) is a synthetic inhibitor of plasmatic and pancreatic serine proteases licensed for the treatment of pancreatitis. Here we show that in suspensions of isolated hepatocytes, profound changes in extracellular, cytoplasmic, and vesicular pH occur after addition of GM. Isolated hepatocytes obtained by collagenase perfusion of rat liver were pre-incubated with 1, 2, and 4 mM GM. Extracellular pH (pH in the incubation medium) was measured by a conventional pH electrode, cytosolic and vesicular pH were measured by fluorescence changes of 2',7'-biscarboxyethyl-5,6-carboxyfluorescein acetoxymethyl ester (BCECF-AM) and fluorescein dextran, respectively. Incubation of hepatocytes with GM resulted in a dose-dependent decrease of extracellular pH. Cytosolic pH decreased rapidly and markedly in a dose-dependent manner during the first minutes and gradually returned towards baseline. Simultaneously, GM induced a rapid alkalinization of acidic vesicles. The presence of bis-(p-nitrophelyl) phosphate (BNPP), an esterase inhibitor, reduced the extent of extracellular acidification. Incubation of hepatocytes in the presence of dimethylamiloride, an Na+/H+ exchanger inhibitor, or in a sodium-free medium, did not modify the rate and extent of extracellular acidification. GM, a commercially available pharmacological agent, could be useful to manipulate extra- and intracellular pH. | 2014 Jul-Sep | International journal of immunopathology and pharmacology | No DOI | [
{
"LastName": "Imberti",
"FirstName": "R",
"Affiliation": "Scientific Directorate, University of Pavia, Pavia, Italy."
},
{
"LastName": "Ferrigno",
"FirstName": "A",
"Affiliation": "Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy."
},
{
"LastName": "Tartaglia",
"FirstName": "A",
"Affiliation": "Department of Anesthesiology and Critical Care Medicine, University of Pavia, Pavia, Italy."
},
{
"LastName": "Rizzo",
"FirstName": "V",
"Affiliation": "Department of Molecular Medicine, University of Pavia and Foundation IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy."
},
{
"LastName": "Richelmi",
"FirstName": "P",
"Affiliation": "Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy."
},
{
"LastName": "Vairetti",
"FirstName": "M",
"Affiliation": "Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy."
}
] | No |
34296292 | Progression of melanoma is suppressed by targeting all transforming growth factor‑β isoforms with an Fc chimeric receptor. | Melanoma is an aggressive type of cancer originating from the skin that arises from neoplastic changes in melanocytes. Transforming growth factor‑β (TGF‑β) is a pleiotropic cytokine and is known to contribute to melanoma progression by inducing the epithelial‑mesenchymal transition (EMT) program and creating an environment that favors tumor progression. There are three TGF‑β isoforms, TGF‑β1, TGF‑β2 and TGF‑β3, all of which engage in pro‑tumorigenic activities by activating SMAD signaling pathways. All TGF‑β isoforms activate signaling pathways by binding to their TGF‑β type I (TβRI) and type II (TβRII) receptors. Thus, effective targeting of all TGF‑β isoforms is of great importance. In the present study, chimeric proteins comprising the extracellular domains of TβRI and/or TβRII fused with the Fc portion of human immunoglobulin (IgG) were validated in the melanoma context. The Fc chimeric receptor comprising both TβRI and TβRII (TβRI‑TβRII‑Fc) effectively trapped all TGF‑β isoforms. Conversely, TβRII‑Fc chimeric receptor, that comprises TβRII only, was able to interact with TGF‑β1 and TGF‑β3 isoforms, but not with TGF‑β2, which is a poor prognostic factor for melanoma patients. Accordingly, it was revealed that TβRI‑TβRII‑Fc chimeric receptor suppressed the EMT program in melanoma cells in vitro induced by any of the three TGF‑β isoforms, as revealed by decreased expression of mesenchymal markers. Conversely, TβRII‑Fc chimeric receptor inhibited the EMT program induced by TGF‑β1 and TGF‑β3. In addition, it was established that tumor growth in subcutaneous mouse melanoma was inhibited by TβRI‑TβRII‑Fc chimeric receptor indicating that Fc chimeric receptor could be applied to modify the tumor microenvironment (TME) of melanoma. Therefore, designing of Fc chimeric receptors targeting TGF‑β signals that affect various components of the TME may result in the development of effective anti‑melanoma agents. | 2021 Sep | Oncology reports | No DOI | [
{
"LastName": "Kodama",
"FirstName": "Shingo",
"Affiliation": "The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565‑0871, Japan."
},
{
"LastName": "Podyma-Inoue",
"FirstName": "Katarzyna Α",
"Affiliation": "Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo 113‑8549, Japan."
},
{
"LastName": "Uchihashi",
"FirstName": "Toshihiro",
"Affiliation": "The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565‑0871, Japan."
},
{
"LastName": "Kurioka",
"FirstName": "Kyoko",
"Affiliation": "The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565‑0871, Japan."
},
{
"LastName": "Takahashi",
"FirstName": "Hitomi",
"Affiliation": "Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo 113‑8549, Japan."
},
{
"LastName": "Sugauchi",
"FirstName": "Akinari",
"Affiliation": "The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565‑0871, Japan."
},
{
"LastName": "Takahashi",
"FirstName": "Kazuki",
"Affiliation": "Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo 113‑8549, Japan."
},
{
"LastName": "Inubushi",
"FirstName": "Toshihiro",
"Affiliation": "Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Suita, Osaka 565‑0871, Japan."
},
{
"LastName": "Kogo",
"FirstName": "Mikihiko",
"Affiliation": "The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565‑0871, Japan."
},
{
"LastName": "Tanaka",
"FirstName": "Susumu",
"Affiliation": "The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565‑0871, Japan."
},
{
"LastName": "Watabe",
"FirstName": "Tetsuro",
"Affiliation": "Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo 113‑8549, Japan."
}
] | No |
17282389 | Predict ultrasonic backscatter coefficient in cancellous bone by theory and experiment. | The scattering mechanism of ultrasound in cancellous bone is investigated theoretically. The relationship of backscatter coefficient (BSC) in cancellous bone with frequency is analyzed in theoretical and experimental. The results of theory and experiment for cancellous bone of bovine tibiae, human calcaneus in vitro and in vivo showed that BSC is a non-linear function of frequency, increasing with frequency. In general, all curve of BSC can be divided into three sections with different slope. The slopes of the first and third section have a large value, and the slope of second section is flat. A good agreement was obtained in the averaged BSC of experiment and cellular model. Those results suggest that the backscatter signal and BSC have a particularly important action in assessment of cancellous bone status and diagnosis of osteoporosis. | 2005 | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference | No DOI | [
{
"LastName": "Ta",
"FirstName": "De-An",
"Affiliation": "Dept. of Electron. Eng., Fudan Univ., Shanghai."
},
{
"LastName": "Huang",
"FirstName": "Kai",
"Affiliation": ""
},
{
"LastName": "Wang",
"FirstName": "Wei-Qi",
"Affiliation": ""
},
{
"LastName": "Wang",
"FirstName": "Yuan-Yuan",
"Affiliation": ""
}
] | No |
38985814 | Investigating stronger tolerant network against cascading failures in focusing on changing degree distributions. | Many real-world networks with Scale-Free structure are significantly vulnerable against both intentional attacks and catastrophic cascading failures. On the other hand, it has been shown that networks with narrower degree distributions have strong robustness of connectivity by enhancing loops. This paper numerically reveals that such networks are also tolerant against cascading failures. Our findings will be useful in designing stronger tolerant network infrastructures. | 2024 | PloS one | No DOI | [
{
"LastName": "Kusunoki",
"FirstName": "Ryota",
"Affiliation": "Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan."
},
{
"LastName": "Hayashi",
"FirstName": "Yukio",
"Affiliation": "Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan."
}
] | No |
28649401 | Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients. | Coronary artery disease is an inflammatory disorder characterized by narrowing of coronary arteries due to atherosclerotic plaque formation. To date, the accumulated epidemiological evidence supports an association between oral bacterial diseases and coronary artery disease, but has failed to prove a causal link between the two. Due to the recent surge in microbial identification and analyses techniques, a number of bacteria have been independently found in atherosclerotic plaque samples from coronary artery disease patients. In this study, we present meta-analysis from published studies that have independently investigated the presence of bacteria within atherosclerotic plaque samples in coronary artery disease patients. Data were collated from 63 studies covering 1791 patients spread over a decade. Our analysis confirms the presence of 23 oral commensal bacteria, either individually or in co-existence, within atherosclerotic plaques in patients undergoing carotid endarterectomy, catheter-based atherectomy, or similar procedures. Of these 23 bacteria, 5 (Campylobacter rectus, Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia, Prevotella nigrescens) are unique to coronary plaques, while the other 18 are additionally present in non-cardiac organs, and associate with over 30 non-cardiac disorders. We have cataloged the wide spectrum of proteins secreted by above atherosclerotic plaque-associated bacteria, and discuss their possible roles during microbial migration via the bloodstream. We also highlight the prevalence of specific poly-microbial communities within atherosclerotic plaques. This work provides a resource whose immediate implication is the necessity to systematically catalog landscapes of atherosclerotic plaque-associated oral commensal bacteria in human patient populations. | 2016 | NPJ biofilms and microbiomes | No DOI | [
{
"LastName": "Chhibber-Goel",
"FirstName": "Jyoti",
"Affiliation": "Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India."
},
{
"LastName": "Singhal",
"FirstName": "Varsha",
"Affiliation": "Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India."
},
{
"LastName": "Bhowmik",
"FirstName": "Debaleena",
"Affiliation": "Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India."
},
{
"LastName": "Vivek",
"FirstName": "Rahul",
"Affiliation": "Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India."
},
{
"LastName": "Parakh",
"FirstName": "Neeraj",
"Affiliation": "Cardiothoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, India."
},
{
"LastName": "Bhargava",
"FirstName": "Balram",
"Affiliation": "Cardiothoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, India."
},
{
"LastName": "Sharma",
"FirstName": "Amit",
"Affiliation": "Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India."
}
] | No |
35514443 | The Children's Data Network: Harnessing the scientific potential of linked administrative data to inform children's programs and policies. | The Children's Data Network (CDN) is a data and research collaborative focused on the linkage and analysis of administrative records. In partnership with public agencies, philanthropic funders, affiliated researchers, and community stakeholders, we seek to generate knowledge and advance evidence-rich policies that improve the health, safety, and well-being of the children of California. Given our experience negotiating access to and working with existing administrative data (and importantly, data stewards), the CDN has demonstrated its ability to perform cost-effective and rigorous record linkage, answer time-sensitive policy- and program-related questions, and build the public sector's capacity to do the same. Owing to steadfast and generous infrastructure and project support, close collaboration with public partners, and strategic analyses and engagements, the CDN has promoted a person-level and longitudinal understanding of children and families in California and in so doing, informed policy and program development nationwide. We sincerely hope that our experience-and lessons learned-can advance and inform work in other fields and jurisdictions. | 2021 | International journal of population data science | No DOI | [
{
"LastName": "Foust",
"FirstName": "Regan",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Hoonhout",
"FirstName": "Jonathan",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Eastman Andrea",
"FirstName": "Lane",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Prindle",
"FirstName": "John",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Rebbe",
"FirstName": "Rebecca",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Nghiem",
"FirstName": "Huy",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Suthar",
"FirstName": "Himal",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Cuccaro-Alamin",
"FirstName": "Stephanie",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Mitchell",
"FirstName": "Michael",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Dawson",
"FirstName": "William",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Palmer",
"FirstName": "Lindsey",
"Affiliation": "Child Maltreatment Solutions Network, Pennsylvania State University, University Park, PA."
},
{
"LastName": "Raj",
"FirstName": "Siddharth",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Ahn",
"FirstName": "Eunhye",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Hammond",
"FirstName": "Ivy",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "McNellan",
"FirstName": "Claire",
"Affiliation": "School of Social Work, University of North Carolina Chapel Hill, Chapel Hill, USA."
},
{
"LastName": "Reddy",
"FirstName": "Julia",
"Affiliation": "Gillings School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, NC."
},
{
"LastName": "Chen",
"FirstName": "Wan-Ting",
"Affiliation": "School of Social Work, University of North Carolina Chapel Hill, Chapel Hill, USA."
},
{
"LastName": "Mayfield",
"FirstName": "Kamilah",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "Putnam-Hornstein",
"FirstName": "Emily",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
},
{
"LastName": "McCroskey",
"FirstName": "Jacquelyn",
"Affiliation": "USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, USA."
}
] | No |
38797312 | Gibberellic acid targeting ZBTB16 reduces NF-κB dependent inflammatory stress in sepsis-induced neuroinflammation. | Sepsis is frequently complicated by neuroinflammation. Gibberellic acid (GA3) is recognized for its anti-inflammatory properties. In this study, our objective was to investigate whether GA3 could alleviate Nuclear factor-kappa B (NF-κB) -dependent inflammatory stress in sepsis-induced neuroinflammation. C57BL/6 J mice were administered 10 mg/kg lipopolysaccharide (LPS) to induce sepsis. BV2 cells were pre-incubated with GA3 and subjected lipopolysaccharide stimulation to replicate the inflammatory microglia during sepsis. Subsequently, we assessed the release of IL-6, TNF-α, and IL-1β, along with the expression of Zbtb16, NF-κB, and IκB. To investigate whether any observed anti-inflammatory effects of GA3 were mediated through a Zbtb16-dependent mechanism, Zbtb16 was silenced using siRNA. GA3 improved the survival of sepsis mice and alleviated post-sepsis cognitive impairment. Additionally, GA3 attenuated microglial M1 activation (pro-inflammatory phenotype), inflammation, and neuronal damage in the brain. Moreover, GA3 inhibited the release of TNF-α, IL-6, and IL-1β in microglia stimulated with LPS. The NF-κB signaling pathway emerged as one of the key molecular pathways associated with the impact of GA3 on LPS-stimulated microglia. Lastly, GA3 upregulated Zbtb16 expression in microglia that had been downregulated by LPS. The inhibitory effects of GA3 on microglial M1 activation were partially reversed through siRNA knockdown of Zbtb16. Pre-incubation of microglia with GA3 led to the upregulation of the NF-κB regulator, Zbtb16. This process counteracted LPS-induced microglial M1 activation, resulting in an anti-inflammatory effect upon subsequent LPS stimulation. | 2024 Aug 5 | European journal of pharmacology | No DOI | [
{
"LastName": "Xu",
"FirstName": "Hao-Jie",
"Affiliation": "Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Institute of Anesthesiology, Fujian Medical University, Fuzhou, 350005, China."
},
{
"LastName": "Lin",
"FirstName": "Ying-Yi",
"Affiliation": "Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Institute of Anesthesiology, Fujian Medical University, Fuzhou, 350005, China."
},
{
"LastName": "Yu",
"FirstName": "Jian-Jun",
"Affiliation": "Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Institute of Anesthesiology, Fujian Medical University, Fuzhou, 350005, China."
},
{
"LastName": "Zhang",
"FirstName": "Na",
"Affiliation": "Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Institute of Anesthesiology, Fujian Medical University, Fuzhou, 350005, China."
},
{
"LastName": "Hu",
"FirstName": "Jia-Min",
"Affiliation": "Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Institute of Anesthesiology, Fujian Medical University, Fuzhou, 350005, China."
},
{
"LastName": "Qu",
"FirstName": "Jin-Shuang",
"Affiliation": "Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Institute of Anesthesiology, Fujian Medical University, Fuzhou, 350005, China."
},
{
"LastName": "Yuan",
"FirstName": "Chao-Mei",
"Affiliation": "Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Institute of Anesthesiology, Fujian Medical University, Fuzhou, 350005, China."
},
{
"LastName": "Chen",
"FirstName": "Da-Qiu",
"Affiliation": "Department of Cardiology, Affiliated Nanping First Hospital, Fujian Medical University, Nanping, 353000, Fujian Province, China."
},
{
"LastName": "Liang",
"FirstName": "Min",
"Affiliation": "Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Institute of Anesthesiology, Fujian Medical University, Fuzhou, 350005, China."
},
{
"LastName": "Cai",
"FirstName": "Hong-da",
"Affiliation": "Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Institute of Anesthesiology, Fujian Medical University, Fuzhou, 350005, China."
},
{
"LastName": "Zeng",
"FirstName": "Kai",
"Affiliation": "Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Institute of Anesthesiology, Fujian Medical University, Fuzhou, 350005, China. Electronic address: [email protected]."
}
] | No |
35321517 | Efficacy of Disitamab Vedotin in Treating HER2 2+/FISH- Gastric Cancer. | Currently, effective therapies for advanced gastric cancer with systemic metastasis are lacking. Pharmacological research has been slowly progressing over the past decades. Here, we report the case of a 56-year-old female with human epidermal growth factor receptor 2 (HER2) expression (IHC 2+/FISH-) in gastric cancer with systemic metastasis. The first-line therapeutic regime consisted of systemic administration of camrelizumab, local arterial infusion of oxaliplatin and arterial embolization, oral apatinib, and PS scheme (oral tegafur-gimeracil-oteracil (S-1) and paclitaxel (PTX), which was administered both intraperitoneally and systemically). After the treatment, a 3-month progression-free survival (PFS) was observed. Due to the occurrence of CTCAE grade 4 adverse reactions, the patient could not tolerate chemotherapy. In the second line of treatment, we replaced the PS scheme with disitamab vedotin and continued the use of carrilizumab and apatinib. After four cycles, efficacy evaluation showed that it was stable disease (SD), only CTCAE 1/2 grade adverse reactions occurred, and endoscopy examination showed local tumor control with a reduction in the ulcer lesion. At the time of submission of the current manuscript, a 6-month PFS was achieved and the treatment was continued. Due to the safety and efficacy of disitamab vedotin observed in our case, we propose that disitamab vedotin could be a promising drug for the treatment of advanced gastric cancer patients with HER2 expression. | 2022 | OncoTargets and therapy | No DOI | [
{
"LastName": "Dai",
"FirstName": "Li",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
},
{
"LastName": "Jin",
"FirstName": "Xiangren",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Liuxing",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Haibin",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
},
{
"LastName": "Yan",
"FirstName": "Zhiqiang",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Guanghai",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
},
{
"LastName": "Liang",
"FirstName": "Baichuang",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
},
{
"LastName": "Huang",
"FirstName": "Fu",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
},
{
"LastName": "Luo",
"FirstName": "Yuling",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
},
{
"LastName": "Chen",
"FirstName": "Taichun",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
},
{
"LastName": "Wang",
"FirstName": "Qian",
"Affiliation": "Department of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001, People's Republic of China."
}
] | No |
37667964 | Comparing the responses of countries and National Health Systems to the COVID-19 pandemic: a critical analysis with a case-report series. | This review aimed to compare the different responses of countries to the pandemic, their National Health Systems, and their impact on citizens' health. This work aimed to create a narrative plot that connects different discussion points and suggests organizational solutions and strategic choices in the face of the pandemic. In particular, this work focused on public health organizations, specifically the European Union and vaccination politics. It is also based on a case report series (about the United States, Germany, Vietnam, New Zealand, Cuba, and Italy), where each country has responded differently to the pandemic in terms of political decisions such as vaccination type, information to citizens, dealings with independent experts, and other specific country factors. In comparing the various models of care systems response to the pandemic, it emerges that: we have found some (few) good practices, but without global coordination, and this is obviously not enough. It is now quite clear that there cannot be a "good answer" in a single nation. Uncoordinated local responses cannot counter a global phenomenon. The second point is that the general context must be considered from a strategic point of view. With the threat of new pandemics (but also of health disasters linked to climate change, pollution, and wars), humanity finds itself at the crossroads between investing in a "democratic" management of international bodies but without power (and at the mercy of the need for funds with consequent conflicts) or in some new leadership proposals that advocate efficiency and problem-solving (and that would probably be able to implement it) but that would place processes totally outside of the public's control. | 2023 Aug | European review for medical and pharmacological sciences | No DOI | [
{
"LastName": "Carta",
"FirstName": "M G",
"Affiliation": "Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy. [email protected]."
},
{
"LastName": "Orrù",
"FirstName": "G",
"Affiliation": ""
},
{
"LastName": "Littera",
"FirstName": "R",
"Affiliation": ""
},
{
"LastName": "Firinu",
"FirstName": "D",
"Affiliation": ""
},
{
"LastName": "Chessa",
"FirstName": "L",
"Affiliation": ""
},
{
"LastName": "Cossu",
"FirstName": "G",
"Affiliation": ""
},
{
"LastName": "Primavera",
"FirstName": "D",
"Affiliation": ""
},
{
"LastName": "Del Giacco",
"FirstName": "S",
"Affiliation": ""
},
{
"LastName": "Tramontano",
"FirstName": "E",
"Affiliation": ""
},
{
"LastName": "Manocchio",
"FirstName": "N",
"Affiliation": ""
},
{
"LastName": "Buonomo",
"FirstName": "C",
"Affiliation": ""
},
{
"LastName": "Scano",
"FirstName": "A",
"Affiliation": ""
}
] | No |
18970565 | Interference-free coulometric titration of water in lithium bis(oxalato)borate using Karl Fischer reagents based on N-methylformamide. | A non-alcoholic coulometric reagent based on N-methylformamide (NMF) was shown to eliminate the severe interference effect caused by the alcohol component of the conventional Karl Fischer (KF) reagent on the battery electrolyte lithium bis(oxalato)borate (LiBOB). For sample amounts up to 240 microg of water, the stoichiometry of the KF reaction deviated only slightly from the ideal 1:1 ratio for the best reagent composition. Both solid and dissolved (in acetonitrile, tetrahydrofuran (THF), and ethylene carbonate/ethyl methyl carbonate) LiBOB were titrated successfully using a Metrohm 756 KF Coulometer with a diaphragm cell. The detection limit was estimated to be 0.5-1 microg of water using 100ml of reagent in this system. | 2006 Mar 15 | Talanta | No DOI | [
{
"LastName": "Larsson",
"FirstName": "William",
"Affiliation": "Department of Chemistry, Analytical Chemistry, Umeå University, Umeå, Sweden. [email protected]"
},
{
"LastName": "Panitz",
"FirstName": "Jan-Christoph",
"Affiliation": ""
},
{
"LastName": "Cedergren",
"FirstName": "Anders",
"Affiliation": ""
}
] | No |
38715681 | Artificial Intelligence in Cardiology and Atherosclerosis in the Context of Precision Medicine: A Scoping Review. | Cardiovascular diseases remain the main cause of death worldwide which makes it essential to better understand, diagnose, and treat atherosclerosis. Artificial intelligence (AI) and novel technological solutions offer us new possibilities and enable the practice of individually tailored medicine. The study was performed using the PRISMA protocol. As of January 10, 2023, the analysis has been based on a review of 457 identified articles in PubMed and MEDLINE databases. The search covered reviews, original articles, meta-analyses, comments, and editorials published in the years 2009-2023. In total, 123 articles met inclusion criteria. The results were divided into the subsections presented in the review (genome-wide association studies, radiomics, and other studies). This paper presents actual knowledge concerning atherosclerosis, in silico, and big data analyses in cardiology that affect the way medicine is practiced in order to create an individual approach and adjust the therapy of atherosclerosis. | 2024 | Applied bionics and biomechanics | No DOI | [
{
"LastName": "Kolaszyńska",
"FirstName": "Oliwia",
"Affiliation": "Department of Internal Medicine, Asklepios Clinic Uckermark, Am Klinikum 1, 16303, Schwedt/Oder, Germany."
},
{
"LastName": "Lorkowski",
"FirstName": "Jacek",
"Affiliation": "Department of Orthopedics, Traumatology and Sports Medicine, Central Clinical Hospital of the Ministry of Internal Affairs and Administration, 137 Woloska Street, Warsaw 02-507, Poland."
}
] | No |
31921256 | Selenium-Enriched Pollen Grains of Olea europaea L.: Ca(2+) Signaling and Germination Under Oxidative Stress. | Selenium (Se) shows antioxidant properties that can be exploited in plants to combat abiotic stresses caused by reactive oxygen species produced in excess (ROS). Here, we show that the Se-fertilization of olive trees with sodium selenate effectively protects the pollen from oxidative stress. Pollen isolated from plants treated with Se or from untreated controls was incubated in vitro with H2O2 to produce an oxidative challenge. Given the impact of ROS on Ca[2+] homeostasis and Ca[2+]-dependent signaling, cytosolic Ca[2+] was measured to monitor cellular perturbations. We found that H2O2 interrupted Ca[2+] homeostasis only in untreated pollen, while in samples treated in vitro with sodium selenate or selenium methionine, Ca[2+] homeostasis was preserved. Furthermore, germination rates were considerably better maintained in Se-fertilized pollen compared to non-fertilized pollen (30% vs. 15%, respectively) after exposure to 1 mM H2O2. The same was observed with pollen treated in vitro with Se-methionine, which is the organic form of Se, in which part of the fertigated sodium selenate is converted in the plant. Combined, our results show a close correlation between ROS, Ca[2+] homeostasis, and pollen fertility and provide clear evidence that Se-fertilization is a potential approach to preserve or improve agricultural productivity. | 2019 | Frontiers in plant science | No DOI | [
{
"LastName": "Del Pino",
"FirstName": "Alberto Marco",
"Affiliation": "Department of Agricultural, Food and Environmental Sciences, Università degli Studi di Perugia, Perugia, Italy."
},
{
"LastName": "Regni",
"FirstName": "Luca",
"Affiliation": "Department of Agricultural, Food and Environmental Sciences, Università degli Studi di Perugia, Perugia, Italy."
},
{
"LastName": "D'Amato",
"FirstName": "Roberto",
"Affiliation": "Department of Agricultural, Food and Environmental Sciences, Università degli Studi di Perugia, Perugia, Italy."
},
{
"LastName": "Tedeschini",
"FirstName": "Emma",
"Affiliation": "Department of Agricultural, Food and Environmental Sciences, Università degli Studi di Perugia, Perugia, Italy."
},
{
"LastName": "Businelli",
"FirstName": "Daniela",
"Affiliation": "Department of Agricultural, Food and Environmental Sciences, Università degli Studi di Perugia, Perugia, Italy."
},
{
"LastName": "Proietti",
"FirstName": "Primo",
"Affiliation": "Department of Agricultural, Food and Environmental Sciences, Università degli Studi di Perugia, Perugia, Italy."
},
{
"LastName": "Palmerini",
"FirstName": "Carlo Alberto",
"Affiliation": "Department of Agricultural, Food and Environmental Sciences, Università degli Studi di Perugia, Perugia, Italy."
}
] | No |
35749072 | Heart rate variability for small animal veterinarians - A concise debate. | This manuscript aims to provide a simple and concise discussion on heart rate variability (HRV) for small animal veterinarians. Despite the fact that heart rate variability analysis techniques have been used for quite a long time in medical sciences, it seems to be not completely understood by a large fraction of veterinarian professionals, thereby, reducing the possible benefits to patients that could arise from such information. The analysis of the R-R intervals enables the veterinarian to evaluate autonomic sympathetic and parasympathetic modulation of the heart, composing the so-called cardiac autonomic balance. Several pathophysiological states lead to profound changes in autonomic balance, especially in the cardiovascular system. Therefore, heart rate variability methods remain a valuable and powerful tool for the diagnosis and prognosis of cardiovascular diseases. | 2021 | Brazilian journal of veterinary medicine | No DOI | [
{
"LastName": "Fernandes",
"FirstName": "Luciano Gonçalves",
"Affiliation": ". Veterinarian, DSc., Departamento de Ciências Fisiológicas,Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro. Campus Seropédica - RJ, Brazil."
},
{
"LastName": "Seara",
"FirstName": "Fernando de Azevedo Cruz",
"Affiliation": ". Veterinarian, DSc., Departamento de Ciências Fisiológicas,Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro. Campus Seropédica - RJ, Brazil."
}
] | No |
38974556 | An extremely rare case of primary alveolar rhabdomyosarcoma in the central nervous system. | Alveolar rhabdomyosarcoma (ARMS) shows a predilection for the peripheral extremities and is very rarely identified as a primary in the brain. Here, we report a case of ARMS with multiple lesions exclusively within the central nervous system (CNS). A 20-year-old man presented to our hospital with a gradually increasing headache and disturbance of consciousness. Neuroimaging showed hydrocephalus and multiple tumor lesions, including in the brainstem and cerebellum, with uniform gadolinium enhancement on T1-weighted magnetic resonance imaging, as well as spinal cord seeding. Cerebrospinal fluid (CSF) analysis showed a slightly elevated cell count (6/μL; normal, <5/μL) and highly elevated protein (153 mg/dL). In addition, atypical cells were cytologically identified in the CSF. No other laboratory findings were abnormal. Emergency ventricular drainage was performed to control cerebral pressure, followed by a biopsy to confirm the diagnosis. Histological examination revealed a fascicular arrangement of oval cells with eosinophilic cytoplasm and tumor cells with pleomorphic nuclei and prominent nucleoli. Immunohistochemical studies showed negative results for glial fibrillary acidic protein and positive results for desmin and myogenin. In addition, molecular analysis revealed that this tumor had the H3F3A p.Lys28Met mutation and no paired box (PAX)3-forkhead box O1 (FOXO1) or PAX7-FOXO1 fusion genes. ARMS was, therefore, diagnosed. Chemotherapy and radiotherapy were subsequently initiated, but tumor growth could not be controlled, and the patient died 6 months after surgery. This report describes an extremely rare case of ARMS arising exclusively within the CNS. | 2024 | Surgical neurology international | No DOI | [
{
"LastName": "Nishikawa",
"FirstName": "Masahiro",
"Affiliation": "Department of Neurosurgery, Ehime University School of Medicine, Toon, Ehime, Japan."
},
{
"LastName": "Inoue",
"FirstName": "Akihiro",
"Affiliation": "Department of Neurosurgery, Ehime University School of Medicine, Toon, Ehime, Japan."
},
{
"LastName": "Moritani",
"FirstName": "Kyoko",
"Affiliation": "Department of Pediatrics, Ehime University School of Medicine, Toon, Ehime, Japan."
},
{
"LastName": "Kagajo",
"FirstName": "Mari",
"Affiliation": "Department of Pediatrics, Ehime University School of Medicine, Toon, Ehime, Japan."
},
{
"LastName": "Kitazawa",
"FirstName": "Riko",
"Affiliation": "Department of Diagnostic Pathology, Ehime University School of Medicine, Toon, Ehime, Japan."
},
{
"LastName": "Kunieda",
"FirstName": "Takeharu",
"Affiliation": "Department of Neurosurgery, Ehime University School of Medicine, Toon, Ehime, Japan."
}
] | No |
38470427 | Three-Component Reaction between 3-Acetylcoumarins, Amines, and Elemental Sulfur: A Designed Approach to 3-Amino-4H-thieno[3,2-c]coumarins. | In this work, a series of novel 3-amino-4H-thieno[3,2-c]coumarins were designed and synthesized by a one-pot, catalyst-free, and three-component reaction of 3-acetylcoumarins with amines and elemental sulfur. Readily available starting materials, simple heating conditions, facile installation of a sulfur atom into the molecule using S8 as a sulfur source, acceptable functional group tolerance, and synthetically useful yields are some highlighted benefits of this process. | 2024 Apr 5 | The Journal of organic chemistry | No DOI | [
{
"LastName": "Farajpour",
"FirstName": "Behnaz",
"Affiliation": "Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran 1993893973, Iran."
},
{
"LastName": "Heydarzadeh",
"FirstName": "Roujin",
"Affiliation": "Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran 1993893973, Iran."
},
{
"LastName": "Hussain",
"FirstName": "Faiq H S",
"Affiliation": "Medical Analysis Department, Applied Science Faculty, Tishk International University, Erbil 44001, Kurdistan Region, Iraq."
},
{
"LastName": "Notash",
"FirstName": "Behrouz",
"Affiliation": "Department of Inorganic Chemistry, Shahid Beheshti University, Tehran 1983969411, Iran."
},
{
"LastName": "Mirzaei",
"FirstName": "Peiman",
"Affiliation": "Department of Organic Chemistry, Shahid Beheshti University, Tehran 1983969411, Iran."
},
{
"LastName": "Shiri",
"FirstName": "Morteza",
"Affiliation": "Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran 1993893973, Iran."
}
] | No |
35924116 | Clinical Manifestations, Imaging Features, and Pathogenic/Prognostic Risk Factors for Temporomandibular Disorders (TMD): A Case-Control Study Based on Psychogenic Factors of Patients. | To survey the clinical manifestations and imaging features of temporomandibular disorders (TMD) and analyze the risk factors for pathogenesis/prognosis through a case-control study based on psychogenic factors of patients. According to the inclusion criteria, 200 adult patients were randomly enrolled from the maxillofacial department of our hospital from January 2020 to May 2021, including 100 patients with TMD as the study group and 100 healthy patients as the control group. The study group can be assigned into four subgroups according to their clinical manifestations: (1) articular area or/and masticatory muscle pain group, (2) mandibular movement abnormality group, (3) joint murmur group, and (4) two or more symptom groups. Based on the study of psychogenic factors of patients, the clinical manifestations and imaging features of TMD were determined, and the risk factors for pathogenesis/prognosis were analyzed. The distribution of psychological status in the TMD group was higher than that in the control group (P < 0.05). The distribution of anxiety, depression, and somatic symptoms in the TMD group was significantly different from that in the control group (P < 0.05). Anxiety, depression, and somatic symptoms were the risk factors for TMD. Compared with the control group, the incidence of abnormal MRI images in patients with temporomandibular disorders was significantly different (P < 0.05). There were significant differences in psychological status (anxiety, depression, and somatic symptoms) among the three groups (P < 0.05). Anxiety, depression, and somatic symptoms were the risk factors for abnormal mandibular movement and joint tremor and murmur (P < 0.05). Somatic symptoms were the risk factors for various clinical symptoms of TMD (P < 0.05). Depression was the risk factor for pain (P < 0.05). In patients with TMD, MRI can early identify disc abnormalities and other related imaging features, which is helpful for more comprehensive clinical evaluation and treatment of TMD patients. There exhibits no significant difference in psychological status (anxiety, depression, and somatic symptoms) of patients with different clinical symptoms, and abnormal psychological status may be one of the risk factors leading to different clinical symptoms and development of different types of TMD patients. | 2022 | Computational and mathematical methods in medicine | No DOI | [
{
"LastName": "Hu",
"FirstName": "Sunqiang",
"Affiliation": "Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325000 Zhejiang Province, China."
},
{
"LastName": "Shao",
"FirstName": "Zhenghao",
"Affiliation": "Department of Endodontics, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325000 Zhejiang Province, China."
},
{
"LastName": "Deng",
"FirstName": "Lichao",
"Affiliation": "Department of Endodontics, School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325000 Zhejiang Province, China."
}
] | Yes |
39006466 | Cardiovascular Implications of Semaglutide in Obesity Management: Redefining Cardiovascular Health Strategies. | Semaglutide is a glucagon-l ike peptide 1 receptor agonist that has been noted to have a significant role in the reduction of body weight and glycaemic control. An increasing body of evidence from recent trials (SUSTAIN-6, SELECT and STEP HF) has shown significant cardiovascular benefits of semaglutide in both patients with and without diabetes and in people who are obese or overweight. Additional studies in a more diverse patient population and safety assessment are warranted prior to adding semaglutide to the increasing pool of guideline-directed medical therapy for the treatment and prevention of cardiac diseases. | 2024 | Heart international | No DOI | [
{
"LastName": "Binu",
"FirstName": "Aditya John",
"Affiliation": "Department of Cardiology, Christian Medical College Vellore, Tamil Nadu, India."
},
{
"LastName": "Kapoor",
"FirstName": "Nitin",
"Affiliation": "Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India."
}
] | No |
34125333 | Sex dimorphism of life-history traits and their response to environmental factors in spider mites. | Sex dimorphism is ubiquitous in the animal kingdom and can be influenced by environmental factors. However, relatively little is known about how the degree and direction of sex difference vary with environmental factors, including food quality and temperature. With the spider mites from the family Tetranychidae as subjects, the sex difference of life-history traits in responses to host plant and temperature were determined in this meta-analytic review. Across the 42 studies on 26 spider mite species (N = 8057 and 3922 for female and male mites, respectively), female spider mites showed longer developmental duration than the males in all except two species. The direction of sex difference in development was consistent regardless of temperature and host plant. The 16 spider mite species in 33 studies generally showed female-biased longevity, with an overall effect size of 0.6043 [95%CI = 0.4054-0.8031]. Host plant significantly influenced the sex difference in longevity, where the males lived longer than females below 22.5 ℃, but the reverse was true at higher and fluctuating temperature. Host plant also influenced the magnitude of sex difference in longevity, with females living longer than males when reared on herbs but not on trees. This study indicated that life-history traits are highly variable between sexes under temperature and host plant influence, highlighting that environmental conditions can significantly shape the direction and magnitude of sexual dimorphism of life-history traits. | 2021 Jul | Experimental & applied acarology | No DOI | [
{
"LastName": "Li",
"FirstName": "Guang-Yun",
"Affiliation": "Centre for Biodiversity & Biosecurity, School of Biological Sciences, University of Auckland, Auckland, New Zealand."
},
{
"LastName": "Zhang",
"FirstName": "Zhi-Qiang",
"Affiliation": "Centre for Biodiversity & Biosecurity, School of Biological Sciences, University of Auckland, Auckland, New Zealand. [email protected]."
}
] | No |
32027089 | Restoration of microRNA-197 expression suppresses oncogenicity in fibrosarcoma through negative regulation of RAN. | MicroRNAs (miRNAs) act as crucial regulators of biological pathways/processes by reinforcing transcriptional programs and moderating transcripts. Emerging evidences have shown the involvement of dysregulated miRNAs in pathophysiology of human diseases including several cancer types. Recently, miR-197-3p has been reported to play different roles in different cancers; however, its role in fibrosarcoma, a highly aggressive and malignant soft tissue sarcoma originated from the mesenchymal tissues, has not yet been studied. Therefore, this study aims to investigate the possible regulatory roles of miR-197-3p in the oncogenicity of fibrosarcoma. For this, we initially performed qRT-PCR of miR-197-3p, which we found to be downregulated in HT1080 human fibrosarcoma cells compared with IMR90-tert normal fibroblast cells. Subsequently, we performed gain-of-function study by employing several methods such as MTT assay, clonogenic assay, wound healing, flow cytometry cell cycle analysis, and acridine orange staining after transfecting HT1080 cells with miR-197-3p mimic. From these assays, we observed that miR-197-3p significantly inhibits viability, colony forming, and migration ability as well as triggers G2/M phase cell cycle arrest and autophagy in fibrosarcoma cells. To understand the mechanism through which miRNA performs these functions, we predicted its targets using TargetScan and performed pathway enrichment analysis after screening them by their expression in fibrosarcoma. Among the enriched targets, we found RAN (ras-related nuclear protein) to be a crucial target through which miR-197-3p represses tumorigenesis by binding to its 3´ UTR, validated by luciferase reporter assay. The tumor suppressive role of the miRNA was further confirmed by transfecting its mimic in RAN-overexpressed cells which showed significant attenuation in tumorigenic effect of RAN in fibrosarcoma as seen in different assays. Taken together, our study unveiled that miR-197-3p acts as an oncosuppressor in fibrosarcoma through G2/M phase arrest and induction of autophagy, and raises the possibility to act as a novel therapeutic intervention for the malignancy. | 2020 May | IUBMB life | No DOI | [
{
"LastName": "Jain",
"FirstName": "Neha",
"Affiliation": "RNAi and Functional Genomics Lab., Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, India."
},
{
"LastName": "Das",
"FirstName": "Basudeb",
"Affiliation": "RNAi and Functional Genomics Lab., Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, India."
},
{
"LastName": "Mallick",
"FirstName": "Bibekanand",
"Affiliation": "RNAi and Functional Genomics Lab., Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, India."
}
] | No |
39043729 | Analysis of retinal alterations utilizing intraoperative OCT following surgical interventions with novel ILM forceps in the DISCOVER study. | This study aimed to assess retinal alterations following membrane peeling procedures using novel ILM Forceps with laser ablated surface with the help of intraoperative optical coherence tomography (iOCT). A post-hoc analysis was performed to evaluate iOCT findings in eyes that underwent membrane peeling procedures with the novel ILM Forceps. Pre-peel and post-peel iOCT videos and images were evaluated for each eye to assess for post-peel anatomic alterations. Surgical video/iOCT scan correlation was conducted to evaluate the etiology of anatomic alterations. Thirty-two eyes were included in the analysis. Three eyes (9%) had focal full thickness retinal elevations identified on iOCT following tissue-instrument interaction with the ILM Forceps. Two eyes (6%) had focal inner retinal elevations and one eye (3%) had a full-thickness retinal elevation that were not related to direct tissue-instrument interaction but rather indirect peeling forces. iOCT-identified architectural alterations related to direct-tissue instrument interaction were relatively infrequent (< 10%) with similar frequency to previously reported alterations with other surgical instruments. | 2024 Jul 23 | Scientific reports | No DOI | [
{
"LastName": "Cakir",
"FirstName": "Yavuz",
"Affiliation": "The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA."
},
{
"LastName": "Sassine",
"FirstName": "Antoine G",
"Affiliation": "The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA."
},
{
"LastName": "Amine",
"FirstName": "Reem",
"Affiliation": "The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA."
},
{
"LastName": "Matar",
"FirstName": "Karen",
"Affiliation": "The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA."
},
{
"LastName": "Talcott",
"FirstName": "Katherine E",
"Affiliation": "The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA."
},
{
"LastName": "Srivastava",
"FirstName": "Sunil K",
"Affiliation": "The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA."
},
{
"LastName": "Reese",
"FirstName": "Jamie L",
"Affiliation": "The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA."
},
{
"LastName": "Ehlers",
"FirstName": "Justis P",
"Affiliation": "The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA. [email protected]."
}
] | No |
38946383 | The six scoring systems' prognostic value in predicting 24-hour mortality in septic patients. | The use of scoring systems contributes to the faster identification of septic patients, especially those at a high risk of a fatal outcome. The best scoring system does not exist, so the search for the optimal one is always current. The aim of this study is to estimate the prognostic value of the six scoring systems in predicting 24-hour mortality among septic patients presented at the emergency department. An observational retrospective study was conducted in the Emergency Triage Room (ETR) of the Emergency Center (EC) at the University Clinical Center of Serbia (UCCS) in Belgrade. Consecutive septic patients, according to the Sepsis-3 definition, with or without shock, presented to the ETR and then hospitalized in Intensive Care Units were included in the study. Mortality data within 24 h and on the 28th day were extracted from the Hospital information system or the National mortality database. Scoring systems including sequential organ failure assessment (SOFA), quick sequential organ failure assessment (qSOFA), systemic inflammatory response syndrome (SIRS), National early warning score (NEWS), sepsis patient evaluation in the emergency department (SPEED), and mortality in emergency department sepsis (MEDS) were analyzed for all patients utilizing the available data. The primary outcome of this study was death within 24 hours of triage. Receiver operating characteristic (ROC) analysis was used to determine the most effective scoring system. Lactate was then added to this system to enhance its predictive accuracy. Nineteen out of 120 patients included in the study (15.8%) experienced death within 24 hours of triage. The twenty-eight-day mortality rate was 55%. SOFA score demonstrated the highest predictive value for 24-hour mortality but was only moderately predictive overall, with an area under the receiver operating curve (AUC) of 0.755 (95% CI 0.625-0.885). SPEED, MEDS, and NEVS exhibited modest discriminatory power [0.673 (95% CI 0.543-0.803), 0.665 (95% CI 0.536-0.794), 0.630 (95% CI 0.528-0.724)], while SIRS and qSOFA remained insignificant in predicting 24-hour mortality. The predictive value of the SOFA score was increased by the addition of lactate (AUC 0.865, 95% CI 0.736-0.995; p=0.0081). All scores demonstrated better and satisfactory predictive power for 28-day mortality. SOFA, with the addition of lactate, is a complex but reliable tool for the early stratification of septic patients who are presenting at an emergency department. | 2024 Jun | European review for medical and pharmacological sciences | No DOI | [
{
"LastName": "Djikic",
"FirstName": "M",
"Affiliation": "Emergency Center, University Clinical Center of Serbia, Belgrade, Serbia. [email protected]."
},
{
"LastName": "Milenkovic",
"FirstName": "M",
"Affiliation": ""
},
{
"LastName": "Stojadinovic",
"FirstName": "M",
"Affiliation": ""
},
{
"LastName": "Miladinovic",
"FirstName": "T",
"Affiliation": ""
},
{
"LastName": "Gujanicic",
"FirstName": "D",
"Affiliation": ""
},
{
"LastName": "Milicevic-Nesic",
"FirstName": "I",
"Affiliation": ""
},
{
"LastName": "Uzelac",
"FirstName": "B",
"Affiliation": ""
},
{
"LastName": "Laban",
"FirstName": "M",
"Affiliation": ""
},
{
"LastName": "Markovic",
"FirstName": "D",
"Affiliation": ""
}
] | No |
23346465 | Bacterial adhesion and colonization differences between zirconia and titanium implant abutments: an in vivo human study. | Several parameters have been described for determining the success or failure of dental implants. The surface properties of transgingival implant components have had a great impact on the long-term success of dental implants. The purpose of this study was to compare the tendency of two periodontal pathogens to adhere to and colonize zirconia abutments and titanium alloys both in hard surfaces and soft tissues. Twelve patients participated in this study. Three months after implant placement, the abutments were connected. Five weeks following the abutment connections, the abutments were removed, probing depth measurements were recorded, and gingival biopsies were performed. The abutments and gingival biopsies taken from the buccal gingiva were analyzed using real-time polymerase chain reaction to compare the DNA copy numbers of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and total bacteria. The surface free energy of the abutments was calculated using the sessile water drop method before replacement. Data analyses used the Mann Whitney U-test, and P-values below 0.05 find statistical significance. The present study showed no statistically significant differences between the DNA copy numbers of A. actinomycetemcomitans, P. gingivalis, and total bacteria for both the titanium and zirconia abutments and the biopsies taken from their buccal gingiva. The differences between the free surface energy of the abutments had no influence on the microbiological findings. Zirconia surfaces have comparable properties to titanium alloy surfaces and may be suitable and safe materials for the long-term success of dental implants. | 2012 Dec | Journal of periodontal & implant science | No DOI | [
{
"LastName": "de Oliveira",
"FirstName": "Greison Rabelo",
"Affiliation": "Department of Oral and Maxillofacial Surgery, State University of West Paraná, Cascavel, Brazil."
},
{
"LastName": "Pozzer",
"FirstName": "Leandro",
"Affiliation": ""
},
{
"LastName": "Cavalieri-Pereira",
"FirstName": "Lucas",
"Affiliation": ""
},
{
"LastName": "de Moraes",
"FirstName": "Paulo Hemerson",
"Affiliation": ""
},
{
"LastName": "Olate",
"FirstName": "Sergio",
"Affiliation": ""
},
{
"LastName": "de Albergaría Barbosa",
"FirstName": "Jose Ricardo",
"Affiliation": ""
}
] | Yes |
35488104 | The clinical outcome from early versus delayed minimally invasive intervention for infected pancreatic necrosis: a systematic review and meta-analysis. | While the management of infected pancreatic necrosis (IPN) has evolved in the last two decades with the adoption of minimally invasive interventions (drainage ± debridement), it is unknown whether the principle of delaying intervention inherited from the open surgery era still applies. The aim of the current study was to investigate the impact of the timing of minimally invasive intervention on the outcomes of patients with IPN requiring intervention. PubMed, Embase, MEDLINE and Web of Science databases were searched for appropriate studies. The primary outcome of interest was hospital mortality, the secondary outcomes were the incidence of complications during the hospitalization, including new-onset organ failure, gastrointestinal fistula or perforation, bleeding and length of hospital or intensive care unit (ICU) stay. Seven clinical studies were included with a total of 742 patients with IPN requiring intervention, of whom 321 received early intervention and 421 delayed intervention. Results from the meta-analysis showed that early minimally invasive intervention did not increase hospital mortality (odds ratio 1.65, 95% confidence interval 0.97-2.81; p = 0.06) but was associated with a remarkably prolonged hospital stay and an increased incidence of gastrointestinal fistula or perforation when compared with delayed intervention. Although no firm conclusion can be drawn because of the quality of available studies, it does appear that timing of intervention is a risk factor for adverse outcomes and ought to be investigated more rigorously in prospective studies. | 2022 Jun | Journal of gastroenterology | No DOI | [
{
"LastName": "Gao",
"FirstName": "Lin",
"Affiliation": "Center of Severe Acute Pancreatitis (CSAP), Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China."
},
{
"LastName": "Zhang",
"FirstName": "He",
"Affiliation": "Center of Severe Acute Pancreatitis (CSAP), Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China."
},
{
"LastName": "Li",
"FirstName": "Gang",
"Affiliation": "Center of Severe Acute Pancreatitis (CSAP), Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China."
},
{
"LastName": "Ye",
"FirstName": "Bo",
"Affiliation": "Center of Severe Acute Pancreatitis (CSAP), Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China."
},
{
"LastName": "Zhou",
"FirstName": "Jing",
"Affiliation": "Center of Severe Acute Pancreatitis (CSAP), Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China."
},
{
"LastName": "Tong",
"FirstName": "Zhihui",
"Affiliation": "Center of Severe Acute Pancreatitis (CSAP), Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China."
},
{
"LastName": "Ke",
"FirstName": "Lu",
"Affiliation": "Center of Severe Acute Pancreatitis (CSAP), Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. [email protected]."
},
{
"LastName": "Windsor",
"FirstName": "John A",
"Affiliation": "Surgical and Translational Research Centre, Faculty of Medical and Health Sciences, School of Medicine, University of Auckland, Auckland, New Zealand."
},
{
"LastName": "Li",
"FirstName": "Weiqin",
"Affiliation": "Center of Severe Acute Pancreatitis (CSAP), Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. [email protected]."
}
] | No |
35615686 | Additional Acupuncture Confers a Favorable Long-Term Prognosis for Elderly Hypertensive Patients with Carotid Atherosclerosis after Atorvastatin Treatment. | The purpose of the study is to investigate the clinical efficacy and long-term prognosis of acupuncture (AP) combined with atorvastatin (ATO) in treating senile essential hypertension (EH) complicated with carotid atherosclerosis (CA). 108 elderly EH patients with CA admitted to our hospital between January 2018 and September 2018 were enrolled into the study, consisting of 67 patients who received treatment of AP with ATO (AP + ATO group) and 41 patients who received treatment of ATO alone (ATO group). Comparative outcomes included clinical efficacy, blood pressure (BP), the levels of blood lipids and inflammatory factors, carotid intima-media thickness (IMT), the number of unstable carotid intima plaques, the carotid plaque area, and the incidence of adverse reactions. All patients were followed up for 3 years to evaluate their quality of life and the recurrence rate of CA. The AP + ATO group presented a higher efficacy, a declined BP, and lower posttreatment levels of blood lipids and inflammatory factors than the ATO group (P < 0.05). Reductions were observed in IMT, number of plaques, and plaque area in both groups after treatment, with more significant improvements in the AP + ATO group (P < 0.05). No difference was observed in the incidence of adverse reactions between two groups after treatment (P > 0.05). The follow-up analysis demonstrated a higher SF-36 score and a lower recurrence rate of CA in the AP + ATO group than the ATO group (P < 0.05). The findings suggested that, for elderly EH patients with CA, treatment of AP with ATO offers better clinical efficacy and safety, which not only can decline the BP, but also can reduce blood lipids and plaque formation, and improve quality of life. | 2022 | Evidence-based complementary and alternative medicine : eCAM | No DOI | [
{
"LastName": "Li",
"FirstName": "Jiefang",
"Affiliation": "Traditional Chinese Medicine Department, The Fourth Hospital of Changsha, Changsha, China."
},
{
"LastName": "Wu",
"FirstName": "Dan",
"Affiliation": "Traditional Chinese Medicine Department, The Fourth Hospital of Changsha, Changsha, China."
},
{
"LastName": "Jun Liu",
"FirstName": "Traditional Chinese Medicine Department, The Fourth Hospital of Changsha, Changsha, China.",
"Affiliation": ""
},
{
"LastName": "Li",
"FirstName": "Xi",
"Affiliation": "Traditional Chinese Medicine Department, The Fourth Hospital of Changsha, Changsha, China."
}
] | Yes |
38603196 | Military Responses to the COVID-19 Pandemic Crisis in Latin America: Military Presence, Autonomy, and Human Rights Violations. | The military in Latin America has been extensively involved in pandemic relief operations. This paper analyses the impact of militarization of pandemic relief operations on human rights. It argues that not all militarization is equally harmful to individuals in the region. When troops assume responsibilities regarding medical care and logistical support, human rights violations do not follow. When involved in policing the stay-at-home orders, the extent of human rights violations is explained by the level of operational autonomy the military has in public security operations. The more autonomous the military, more likely abuses are to occur. Additionally, military exposure to judicial prosecution for human rights offenses contributes to the explanation. After gathering original empirical evidence from 14 Latin American democracies on military presence in pandemic relief, we draw our inferences from process tracing on four comparative case studies of Argentina, Brazil, Chile, and El Salvador. | 2023 Apr | Armed forces and society | No DOI | [
{
"LastName": "Acacio",
"FirstName": "Igor",
"Affiliation": "Department of Political Science, University of California, Riverside, Riverside, CA, USA."
},
{
"LastName": "Passos",
"FirstName": "Anaís M",
"Affiliation": "Department of Sociology and Political Science, Federal University of Santa Catarina (UFSC), Florianópolis/SC, Brasil."
},
{
"LastName": "Pion-Berlin",
"FirstName": "David",
"Affiliation": "Department of Political Science, University of California, Riverside, Riverside, CA, USA."
}
] | No |
31921825 | Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca(2+)-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels. | Fracture healing and bone regeneration, particularly in the elderly, remains a challenge. There is an ongoing search for methods to activate osteoblasts, and the application of electrical fields is an attractive approach in this context. Although it is known that such electromagnetic fields lead to osteoblast migration and foster mesenchymal osteogenic differentiation, so far the mechanisms of osteoblast activation remain unclear. Possible mechanisms could rely on changes in Ca[2+]-influx via ion channels, as these are known to modulate osteoblast activity, e.g., via voltage-sensitive, stretch-sensitive, transient-receptor-potential (TRP) channels, or store-operated release. In the present in vitro study, we explored whether electrical fields are able to modulate the expression of voltage-sensitive calcium channels as well as TRP channels in primary human osteoblast cell lines. We show migration speed is significantly increased in stimulated osteoblasts (6.4 ± 2.1 μm/h stimulated, 3.6 ± 1.1 μm/h control), and directed toward the anode. However, within a range of 154-445 V/m, field strength did not correlate with migration velocity. Neither was there a correlation between electric field and voltage-gated calcium channel (Cav3.2 and Cav1.4) expression. However, the expression of TRPM7 significantly correlated positively to electric field strength. TRPM7 channel blockade using NS8593, in turn, did not significantly alter migration speed, nor did blockade of Cav3.2 and Cav1.4 channels using Ni[+] or verapamil, respectively, while a general Ca[2+]-influx block using Mg[2+] accelerated migration. Stimulating store-operated Ca[2+]-release significantly reduced migration speed, while blocking IP3 had only a minor effect (at low and high concentrations of 2-APB, respectively). We conclude that (i) store operated channels negatively modulate migration speed and that (ii) the upregulation of TRPM7 might constitute a compensatory mechanism-which might explain how increasing expression levels at increasing field strengths result in constant migration speeds. | 2019 | Frontiers in bioengineering and biotechnology | No DOI | [
{
"LastName": "Rohde",
"FirstName": "Marco",
"Affiliation": "Rostock University Medical Center, Oscar-Langendorff-Institute of Physiology, Rostock, Germany."
},
{
"LastName": "Ziebart",
"FirstName": "Josefin",
"Affiliation": "Biomechanics and Implant Research Lab, Department of Orthopedics, Rostock University Medical Center, Rostock, Germany."
},
{
"LastName": "Kirschstein",
"FirstName": "Timo",
"Affiliation": "Rostock University Medical Center, Oscar-Langendorff-Institute of Physiology, Rostock, Germany."
},
{
"LastName": "Sellmann",
"FirstName": "Tina",
"Affiliation": "Rostock University Medical Center, Oscar-Langendorff-Institute of Physiology, Rostock, Germany."
},
{
"LastName": "Porath",
"FirstName": "Katrin",
"Affiliation": "Rostock University Medical Center, Oscar-Langendorff-Institute of Physiology, Rostock, Germany."
},
{
"LastName": "Kühl",
"FirstName": "Friederike",
"Affiliation": "Rostock University Medical Center, Oscar-Langendorff-Institute of Physiology, Rostock, Germany."
},
{
"LastName": "Delenda",
"FirstName": "Bachir",
"Affiliation": "Faculty of Computer Science and Electrical Engineering, Institute of General Electrical Engineering, University of Rostock, Rostock, Germany."
},
{
"LastName": "Bahls",
"FirstName": "Christian",
"Affiliation": "Faculty of Computer Science and Electrical Engineering, Institute of General Electrical Engineering, University of Rostock, Rostock, Germany."
},
{
"LastName": "van Rienen",
"FirstName": "Ursula",
"Affiliation": "Faculty of Computer Science and Electrical Engineering, Institute of General Electrical Engineering, University of Rostock, Rostock, Germany."
},
{
"LastName": "Bader",
"FirstName": "Rainer",
"Affiliation": "Biomechanics and Implant Research Lab, Department of Orthopedics, Rostock University Medical Center, Rostock, Germany."
},
{
"LastName": "Köhling",
"FirstName": "Rüdiger",
"Affiliation": "Rostock University Medical Center, Oscar-Langendorff-Institute of Physiology, Rostock, Germany."
}
] | No |
31914803 | MiR-142-3p targeting NUCKS1 inhibits proliferation and invasion of pancreatic cancer cells. | Objective: To investigate the effects of microRNA-142-3p (miR-142-3p) on the biological characteristics of pancreatic cancer cells and its mechanism.Methods: The expression of miR-142-3p and nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1) in pancreatic tissues and four cancer cell lines (Panc-1, BxPC-3, AsPC-1, MIA-PaCa2) were detected by Quantitative PCR (qPCR) or Western blot. The cell viability of pancreatic cancer cells was examined by MTT assay. The apoptosis of pancreatic cancer cells was measured by flow cytometry. Transwell assay was utilized to test the migration and invasion of pancreatic cancer cells. Bioinformatics analysis for miR-142-3p was conducted and the dual luciferase reporter gene assay was utilized to further validate the predicted target relationship. The protein levels of PI3K, p-AKT and T-AKT were analyzed by Western blot.Results: The expression of miR-142-3p was down-regulated, while the expression of NUCKS1 was significantly up-regulated in pancreatic tissues and four cancer cell lines. The expression of miR-142-3p in pancreatic tissues was inversely correlated with NUCKS1 expression. Overexpression of miR-142-3p inhibited the cell viability, cell migration, and invasion, while promoted cell apoptosis of AsPC-1 and MIA-PaCa2 cells. MiR-142-3p targeted NUCKS1 and negatively regulated NUCKS1. Overexpression of miR-142-3p decreased PI3K and p-AKT expression. Up-regulation of NUCKS1 partially reversed the effects of the overexpression of miR-142-3p on the cell viability, cell apoptosis, migration and invasion, as well as PI3K and p-AKT expression in AsPC-1 and MIA-PaCa2 cells.Conclusion: MiR-142-3p regulated the biological characteristics of pancreatic cancer cells by directly targeting NUCKS1. | 2020 Dec | Artificial cells, nanomedicine, and biotechnology | No DOI | [
{
"LastName": "Zhu",
"FirstName": "Kexiang",
"Affiliation": "The Second General Surgery Department, The First Hospital of Lanzhou University, Lanzhou, China."
},
{
"LastName": "Zhang",
"FirstName": "Zhengcong",
"Affiliation": "General Surgery Department, Donggang Branch of the First Hospital of Lanzhou University, Lanzhou, China."
},
{
"LastName": "Zhang",
"FirstName": "Hui",
"Affiliation": "The Second General Surgery Department, The First Hospital of Lanzhou University, Lanzhou, China."
},
{
"LastName": "Wang",
"FirstName": "Zhengfeng",
"Affiliation": "The Second General Surgery Department, The First Hospital of Lanzhou University, Lanzhou, China."
},
{
"LastName": "Wang",
"FirstName": "Fanghong",
"Affiliation": "The Second General Surgery Department, The First Hospital of Lanzhou University, Lanzhou, China."
}
] | Yes |
26998182 | The Research on the Impact of Maca Polypeptide on Sport Fatigue. | In order to study the effect of maca polypeptide on sport fatigue, this paper selected 40 male mice, and they were randomly divided into group A, B, C and D. group A, B and C were fed food with different concentrations of maca polypeptide, and group D was control group. After two weeks of feeding, measured physiological indexes of mice, including blood glucose, urea nitrogen and creatinine. At last gived the experimental results, as well as the analysis. Experimental results show that maca polypeptide can improve the ability of anti-fatigue mice, and in a certain concentration range, the higher the concentration, the better the resistance to fatigue. | 2015 | The open biomedical engineering journal | No DOI | [
{
"LastName": "Miao",
"FirstName": "Hua",
"Affiliation": "Physical Education Department of Xi'an University of Post and Telecommunications, Shaanxi, China."
}
] | Yes |
32072832 | CD32a polymorphism rs1801274 affects the risk of Kawasaki disease. | Aim: To analyze the impact of CD32a polymorphism rs1801274 on the occurrence of Kawasaki disease (KD) through the meta-analysis.Methods: The correlation between CD32a polymorphism rs1801274 and the susceptibility to KD was appraised using summarized odds ratios (ORs) with their 95% confidence intervals (95% CIs). Besides, stratification analyses were further implemented on the basis of ethnicity and control source, respectively. Between-study heterogeneity was checked adopting chi-square-based Q test, with p < .05 as significant level. And results from Q test determined which model would be employed for OR calculation, fixed- or random-effects. Sensitivity analysis was accomplished to test the stability of final results. Potential publication bias among included studies was investigated using Begg's funnel plot and Egger's test. If publication bias was significant, its influence on overall estimates would be measured adopting the trim-and-fill method.Results: CD32a polymorphism rs1801274 significantly increased KD risk in total analysis under the comparisons of AA vs. GG, AA + AG vs. GG, AA vs. GG + AG, A vs. G and AG vs. GG (OR = 2.69, 95% CI = 1.39-5.20; OR = 2.00, 95% CI = 1.23-3.26; OR = 1.90, 95% CI = 1.23-2.94; OR = 1.77, 95% CI = 1.34-2.34; OR = 1.53, 95% CI = 1.07-2.19). After stratification analysis by ethnicity, similar tendency was also observed in Caucasian and Asian subgroups under corresponding genetic models. And parallel results were replicated in population-based and other-source subgroups after stratified analysis by control source, under some contrasts.Conclusion: CD32a polymorphism rs1801274 has strong relation to KD onset, and the presence of its A allele could elevate the disease incidence. | 2020 Dec | Artificial cells, nanomedicine, and biotechnology | No DOI | [
{
"LastName": "Wang",
"FirstName": "Zhiyong",
"Affiliation": "Department of Pediatrics, Weifang Maternal and Child Health Hospital, Weifang, China."
},
{
"LastName": "Geng",
"FirstName": "Pei-Liang",
"Affiliation": "Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China."
}
] | No |
35838301 | Relationship between Anterior Pituitary Volume and IGF-1 Serum Levels in Soldiers with Mild Traumatic Brain Injury History. | A high mild traumatic brain injury (mTBI) incidence rate exists in military and sport. Hypopituitarism is an mTBI sequela; however, few studies have examined this phenomenon in those with an mTBI history. This cross-sectional study of Special Operations Forces combat soldiers aimed 1) to relate anterior pituitary gland volumes (actual and normalized) to insulin-like growth factor 1 (IGF-1) concentrations, 2) to examine the effect of mTBI history on anterior pituitary gland volumes (actual and normalized) and IGF-1 concentrations, and 3) to measure the odds of demonstrating lower anterior pituitary gland volumes (actual and normalized) or IGF-1 concentrations if self-reporting mTBI history. Anterior pituitary gland volumes were manually segmented from T1-weighted 3D brain MRI sequences; IGF-1 serum concentrations were quantified using commercial enzyme-linked immunosorbent assays. Correlations and linear regression were used to determine the association between IGF-1 serum concentration and anterior pituitary gland volume (n = 74). Independent samples t-tests were used to compare outcomes between mTBI groups and logistic regression models were fit to test the odds of demonstrating IGF-1 concentration or anterior pituitary volume less than sample median based on mTBI group (n = 54). A significant linear relationship between the subjects' anterior pituitary gland volumes and IGF-1 concentrations (r72 = 0.35, P = 0.002) was observed. Soldiers with mTBI history had lower IGF-1 concentrations (P < 0.001) and lower anterior pituitary gland volumes (P = 0.037) and were at greater odds for IGF-1 serum concentrations less than the sample median (odds ratio = 5.73; 95% confidence interval = 1.77-18.55). Anterior pituitary gland volume was associated with IGF-1 serum concentrations. Mild TBI history may be adversely associated with anterior pituitary gland volumes and IGF-1 concentrations. Longitudinal IGF-1 and anterior pituitary gland monitoring may be indicated in those who report one or more mTBI. | 2022 Aug 1 | Medicine and science in sports and exercise | No DOI | [
{
"LastName": "Castellano",
"FirstName": "Anna K",
"Affiliation": "Department of Exercise and Sport Science, Matthew Gfeller Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC."
},
{
"LastName": "Powell",
"FirstName": "Jacob R",
"Affiliation": "Department of Exercise and Sport Science, Matthew Gfeller Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC."
},
{
"LastName": "Cools",
"FirstName": "Michael J",
"Affiliation": "Department of Exercise and Sport Science, Matthew Gfeller Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC."
},
{
"LastName": "Walton",
"FirstName": "Samuel R",
"Affiliation": "Department of Exercise and Sport Science, Matthew Gfeller Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC."
},
{
"LastName": "Barnett",
"FirstName": "Randaline R",
"Affiliation": "Department of Exercise and Sport Science, Matthew Gfeller Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC."
},
{
"LastName": "Delellis",
"FirstName": "Stephen M",
"Affiliation": "Fort Bragg Research Institute, The Geneva Foundation, Tacoma, WA."
},
{
"LastName": "Goldberg",
"FirstName": "Richard L",
"Affiliation": "Department of Applied Physical Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, NC."
},
{
"LastName": "Kane",
"FirstName": "Shawn F",
"Affiliation": "Department of Family Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC."
},
{
"LastName": "Means",
"FirstName": "Gary E",
"Affiliation": "United States Army Special Operations Command, Fort Bragg, NC."
},
{
"LastName": "Zamora",
"FirstName": "Carlos A",
"Affiliation": "Department of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC."
},
{
"LastName": "Depenbrock",
"FirstName": "Patrick J",
"Affiliation": "United States Army Special Operations Command, Fort Bragg, NC."
},
{
"LastName": "Mihalik",
"FirstName": "Jason P",
"Affiliation": "Department of Exercise and Sport Science, Matthew Gfeller Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC."
}
] | No |
37603611 | Epigenetic histone modification by butyrate downregulates KIT and attenuates mast cell function. | Short-chain fatty acid butyrate is produced from the bacterial fermentation of indigestible fiber in the intestinal lumen, and it has been shown to attenuate lung inflammation in murine asthma models. Mast cells (MCs) are initiators of inflammatory response to allergens, and they play an important role in asthma. MC survival and proliferation is regulated by its growth factor stem cell factor (SCF), which acts through the receptor, KIT. It has previously been shown that butyrate attenuates the activation of MCs by allergen stimulation. However, how butyrate mechanistically influences SCF signalling to impact MC function remains unknown. Here, we report that butyrate treatment triggered the modification of MC histones via butyrylation and acetylation, and inhibition of histone deacetylase (HDAC) activity. Further, butyrate treatment caused downregulation of SCF receptor KIT and associated phosphorylation, leading to significant attenuation of SCF-mediated MC proliferation, and pro-inflammatory cytokine secretion. Mechanistically, butyrate inhibited MC function by suppressing KIT and downstream p38 and Erk phosphorylation, and it mediated these effects via modification of histones, acting as an HDAC inhibitor and not via its traditional GPR41 (FFAR3) or GPR43 (FFAR2) butyrate receptors. In agreement, the pharmacological inhibition of Class I HDAC (HDAC1/3) mirrored butyrate's effects, suggesting that butyrate impacts MC function by HDAC1/3 inhibition. Taken together, butyrate epigenetically modifies histones and downregulates the SCF/KIT/p38/Erk signalling axis, leading to the attenuation of MC function, validating its ability to suppress MC-mediated inflammation. Therefore, butyrate supplementations could offer a potential treatment strategy for allergy and asthma via epigenetic alterations in MCs. | 2023 Oct | Journal of cellular and molecular medicine | No DOI | [
{
"LastName": "Gudneppanavar",
"FirstName": "Ravindra",
"Affiliation": "Department of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA."
},
{
"LastName": "Sabu Kattuman",
"FirstName": "Emma Elizabeth",
"Affiliation": "Department of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA."
},
{
"LastName": "Teegala",
"FirstName": "Lakshminarayan Reddy",
"Affiliation": "Department of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA."
},
{
"LastName": "Southard",
"FirstName": "Erik",
"Affiliation": "Department of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA."
},
{
"LastName": "Tummala",
"FirstName": "Ramakumar",
"Affiliation": "Department of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA."
},
{
"LastName": "Joe",
"FirstName": "Bina",
"Affiliation": "Department of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA."
},
{
"LastName": "Thodeti",
"FirstName": "Charles K",
"Affiliation": "Department of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA."
},
{
"LastName": "Paruchuri",
"FirstName": "Sailaja",
"Affiliation": "Department of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA."
}
] | No |
25685326 | Case Report: Large nested variant urothelial carcinoma -invasive malignancy masquerading as low grade disease. | Introduction The large nested variant of urothelial carcinoma (LNVUC) is a newly described and rare subtype of urothelial carcinoma. It is characterised by bland cytological features and a large nested architecture similar in appearance to low grade urothelial carcinoma with an inverted growth pattern. To date only 23 cases in a single series have been described. Case Report We describe the case of a 59 year old male with LNVUC whose tumour was initially misdiagnosed as a non-invasive low grade urothelial carcinoma. At a subsequent re-resection, his tumour was correctly re-classified as LNVUC with extensive invasion of the muscularis propria. Radical cystectomy and formation of an ileal conduit was performed. His operative specimen revealed invasion of prostatic stroma and perivesical fat, with all surgical margins clear. He is currently free from clinical recurrence 12 months after his cystectomy. Conclusion LNVUC is a newly described and rare urothelial carcinoma subtype. It characteristically possesses bland cytological features and may mimic low grade urothelial cancer. Despite its bland appearance it behaves aggressively with invasion, metastasis and death being common. | 2014 | F1000Research | No DOI | [
{
"LastName": "Keller",
"FirstName": "Andrew",
"Affiliation": "Department of Urology, Ipswich General Hospital, Ipswich, QLD, 4305, Australia."
},
{
"LastName": "Lim",
"FirstName": "Ai Jye",
"Affiliation": "Department of Anatomical Pathology, Princess Alexandra Hospital, Woolloongabba, QLD, 4102, Australia."
},
{
"LastName": "Ali",
"FirstName": "Ahmad",
"Affiliation": "Department of Urology, Ipswich General Hospital, Ipswich, QLD, 4305, Australia."
}
] | No |
21191346 | [Combined approaches to diagnostics and treatment of traumatic otitis]. | A total of 216 patients with the injured tympanic membrane were examined and treated during the last 5 years. 198 (91.6%) patients presenting with traumatic otitis were found to have pathological changes in the nose and paranasal sinuses. In patients who applied for medical aid soon (within 1-2 weeks) after injury to the tympanic membrane, the resulting perforation was closed with the use of hen's egg amniotic membrane. Audiological examination demonstrated that 84.7% of traumatic tympanic membrane ruptures were associated with acute sensorinerual loss of hearing. | 2010 | Vestnik otorinolaringologii | No DOI | [
{
"LastName": "Poliakova",
"FirstName": "S D",
"Affiliation": ""
},
{
"LastName": "Bateneva",
"FirstName": "N N",
"Affiliation": ""
},
{
"LastName": "Popova",
"FirstName": "E A",
"Affiliation": ""
}
] | No |
30657170 | Telephone health survey estimates: Effects of nonresponse and sample limitations. | The objective of this study was to assess nonresponse error in telephone health survey data based on an address-based sample. Telephone and in-person interviews in Greater Boston. Interviewers attempted telephone interviews at addresses that were matched to telephone numbers using questions drawn from federal health surveys. In-person household interviews were carried out with telephone nonrespondents and at addresses without matching telephone numbers. After adjusting for demographic differences, only eight of 15 estimates based on the telephone interviews lay within two standard errors of the estimates when data from all three groups were included. For health surveys of address-based samples, many estimates based on telephone respondents differ from the total population in ways that cannot be corrected with simple demographic adjustments. | 2019 Jun | Health services research | No DOI | [
{
"LastName": "Fowler",
"FirstName": "Floyd J",
"Affiliation": "Center for Survey Research, UMass Boston, Boston, Massachusetts."
},
{
"LastName": "Brenner",
"FirstName": "Philip S",
"Affiliation": "Center for Survey Research, UMass Boston, Boston, Massachusetts."
},
{
"LastName": "Buskirk",
"FirstName": "Trent D",
"Affiliation": "Center for Survey Research, UMass Boston, Boston, Massachusetts."
},
{
"LastName": "Roman",
"FirstName": "Anthony",
"Affiliation": "Center for Survey Research, UMass Boston, Boston, Massachusetts."
}
] | No |
38659608 | A Bibliometric Analysis of Study of Associations of Certain Genotypes with the Cardiovascular Form of Diabetic Neuropathy. | This bibliometric analysis explores the landscape of research on the associations between specific genotypes and the cardiovascular form of diabetic neuropathy. Diabetes mellitus (DM) is a major contributor to premature mortality, primarily due to increased susceptibility to cardiovascular diseases. The global prevalence of DM is rising, with projections indicating further increases. Diabetic neuropathy, a complication of DM, includes the cardiovascular subtype, posing challenges in diagnosis and management. Understanding the genetic basis of cardiovascular diabetic neuropathy is crucial for targeted therapeutic interventions. The study utilizes bibliometric analysis to synthesize existing literature, identify trends, and guide future research. The Scopus database was searched, applying inclusion criteria for English articles related to genotypes and cardiovascular diabetic neuropathy. The analysis reveals a dynamic field with a notable impact, collaborative efforts, and multidimensional aspects. Publication trends over 1997-2023 demonstrate fluctuating research intensity. Top journals, authors, and affiliations are highlighted, emphasizing global contributions. Keyword analysis reveals thematic trends, and citation analysis identifies influential documents. Limitations include database biases, incomplete metadata, and search query specificity. The urgent need to explore genetic factors in cardiovascular diabetic neuropathy aligns with the increasing global diabetes burden. This analysis provides a comprehensive overview, contributing to the broader discourse on diabetic neuropathy research. | 2024 | BioMed research international | No DOI | [
{
"LastName": "Bekenova",
"FirstName": "Nazira B",
"Affiliation": "Gerontology Center, Medical Center of the President's Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan."
},
{
"LastName": "Vochshenkova",
"FirstName": "Tamara A",
"Affiliation": "Gerontology Center, Medical Center of the President's Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan."
},
{
"LastName": "Ablakimova",
"FirstName": "Nurgul",
"Affiliation": "Department of Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan."
},
{
"LastName": "Zhylkybekova",
"FirstName": "Aliya",
"Affiliation": "Department of Evidence-Based Medicine and Scientific Management, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan."
},
{
"LastName": "Mussin",
"FirstName": "Nadiar M",
"Affiliation": "General Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan."
},
{
"LastName": "Albayev",
"FirstName": "Rustam K",
"Affiliation": "Gerontology Center, Medical Center of the President's Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan."
},
{
"LastName": "Kaliyev",
"FirstName": "Asset A",
"Affiliation": "General Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan."
},
{
"LastName": "Tamadon",
"FirstName": "Amin",
"Affiliation": "Department for Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan."
}
] | No |
38853239 | The impact of hypoxia preconditioning on mesenchymal stem cells performance in hypertensive kidney disease. | Autologous mesenchymal stem cells (MSCs) have emerged as a therapeutic option for many diseases. Hypertensive kidney disease (HKD) might impair MSCs' reparative ability by altering the biomolecular properties, but the characteristics of this impairment are unclear. In our previous pre-clinical studies, we found hypoxic preconditioning (HPC) enhanced angiogenesis and suppressed senescence gene expression. Thus, we hypothesize that HPC would improve human MSCs by enhancing their functionality and angiogenesis, creating an anti-inflammatory and anti-senescence environment. MSC samples (n = 12 each) were collected from the abdominal fat of healthy kidney donors (HC), hypertensive patients (HTN), and patients with hypertensive kidney disease (HKD). MSCs were harvested and cultured in Normoxic (20% O2) or Hypoxic (1% O2) conditions. MSC functionality was measured by proliferation assays and cytokine released in conditioned media. Senescence was evaluated by senescence-associated beta-galactosidase (SA-beta-gal) activity. Additionally, transcriptome analysis using RNA-sequencing and quantitative PCR (qPCR) were performed. At baseline, normoxic HTN-MSCs had higher proliferation capacity compared to HC. However, HPC augmented proliferation in HC. HPC did not affect the release of pro-angiogenic protein VEGF, but increased EGF in HC-MSC, and decreased HGF in HC and HKD MSCs. Under HPC, SA-β-gal activity tended to decrease, particularly in HC group. HPC upregulated mostly the pro-angiogenic and inflammatory genes in HC and HKD and a few senescence genes in HKD. HPC has a more favorable functional effect on HC- than on HKD-MSC, reflected in increased proliferation and EGF release, and modest decrease in senescence, whereas it has little effect on HTN or HKD MSCs. | 2024 Jun 9 | Stem cell research & therapy | No DOI | [
{
"LastName": "Sohi",
"FirstName": "Gurparneet Kaur",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Farooqui",
"FirstName": "Naba",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Mohan",
"FirstName": "Arjunmohan",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Rajagopalan",
"FirstName": "Kamalnath Sankaran",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Xing",
"FirstName": "Li",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Zhu",
"FirstName": "Xiang Y",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Jordan",
"FirstName": "Kyra",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Krier",
"FirstName": "James D",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Saadiq",
"FirstName": "Ishran M",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Tang",
"FirstName": "Hui",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Hickson",
"FirstName": "LaTonya J",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, USA."
},
{
"LastName": "Eirin",
"FirstName": "Alfonso",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Lerman",
"FirstName": "Lilach O",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA."
},
{
"LastName": "Herrmann",
"FirstName": "Sandra M",
"Affiliation": "Division of Nephrology and Hypertension, Mayo Clinic, 200, First Street SW, Rochester, 55902, MN, USA. [email protected]."
}
] | No |
32027333 | [Possibility of application Mexidol for the treatment of patients suffering from sensorineural hearing loss and cerebrovascular insufficiency]. | Sensorineural hearing loss can develop as a consequence of vascular pathology. The etiology and pathogenesis of chronic sensorineural hearing loss allow us to consider promising the use of neuroprotective drugs in the treatment regimen that can activate the function of the neural structures of the auditory pathway. Ethylmethylhydroxypyridine succinate, having complex pharmacological capabilities and a wide range of effects realized at the neural and vascular levels can be used in the treatment of hearing impairment and speech intelligibility. | 2019 | Vestnik otorinolaringologii | No DOI | [
{
"LastName": "Kunelskaya",
"FirstName": "N L",
"Affiliation": "L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152; Department of Otorhinolaryngology N.I. Pirogov Russian National Research Medical University, Moscow, Russia,117997."
},
{
"LastName": "Levina",
"FirstName": "Yu V",
"Affiliation": "L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152; Department of Otorhinolaryngology N.I. Pirogov Russian National Research Medical University, Moscow, Russia,117997."
},
{
"LastName": "Yanyushkina",
"FirstName": "E S",
"Affiliation": "L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152."
},
{
"LastName": "Ogorodnikov",
"FirstName": "D S",
"Affiliation": "L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152; Department of Otorhinolaryngology N.I. Pirogov Russian National Research Medical University, Moscow, Russia,117997."
},
{
"LastName": "Larionova",
"FirstName": "E V",
"Affiliation": "L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152."
}
] | No |
37593523 | Neurological Effects of Combining Low Toxic Dose of Tramadol and Nicotine: An Animal Model Evidence of Endoplasmic Reticulum Stress. | Tramadol abuse is a common problem in the Middle East in conjunction with smoking. The current study applied immunohistochemistry, western blot, real-time PCR, and ELISA to test the combination toxicity. Low toxic doses of tramadol induced animal brain cortex inflammation and hippocampus injury. Adding nicotine reverted hippocampus pathological changes without triggering marked brain injury. The expression of CHOP protein with real-time PCR showed mild endoplasmic reticulum stress (ER) in rat's brain. Histological, immunohistochemical, and western blotting analysis of CHOP (CCAAT-enhancer-binding protein homologous protein) and BIP (immunoglobulin heavy chain-binding protein) chaperones demonstrated endoplasmic reticulum stress in the brains of animals. Furthermore, the levels of apoptosis and autophagy markers demonstrated a mild reaction. The blood level of serotonin was high in all study groups, with a marked increase in the combined one. The high serotonin levels in the blood can be critical and associated with a high risk of serious withdrawal and pathological consequences. Serotonin receptor blockers such as olanzapine may increase systemic serotonin levels and need further investigation to utterly pinpoint their roles in managing mood disorders. In conclusion, the combination of tramadol and nicotine is less harmful than expected. However, serious withdrawal effects can occur as a result of high systemic serotonin effects. | 2023 | BioMed research international | No DOI | [
{
"LastName": "Ghorab",
"FirstName": "Doaa",
"Affiliation": "Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Yarmouk, Irbid, Jordan."
},
{
"LastName": "Abu-El-Rub",
"FirstName": "Ejlal M",
"Affiliation": "Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Yarmouk, Irbid, Jordan."
},
{
"LastName": "Gharaibeh",
"FirstName": "Mohamed Hamdi",
"Affiliation": "Department of Basic Veterinary Medical Sciences, Faculty of Veterinary, Jordan University of Science and Technology, Irbid, Jordan."
},
{
"LastName": "Yehya",
"FirstName": "Alaa",
"Affiliation": "Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan."
},
{
"LastName": "Khasawneh",
"FirstName": "Ramada R",
"Affiliation": "Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Yarmouk, Irbid, Jordan."
},
{
"LastName": "Matalqah",
"FirstName": "Laila M",
"Affiliation": "Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Yarmouk, Irbid, Jordan."
},
{
"LastName": "Helaly",
"FirstName": "Ahmed Mohamed",
"Affiliation": "Forensic Medicine and Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt."
}
] | No |
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