Skip Ribbon Commands
Skip to main content


Drug Class: Commonly Known As: Category:
Mineralocorticoid Receptor Antagonist

Eplerenone - What is it for

​Eplerenone belongs to a class of medications called Mineralocorticoid Receptor Antagonist (MRA). It works on your kidneys to remove extra water and salts in your body. This will decrease the pressure on the blood vessels and allow the heart to work less hard. It is also used to reduce the amount of fluid present in the lungs as a result of heart failure.

Heart failure is a condition where the heart is weak and is unable to pump enough blood to the rest of the body. This medication is used in heart failure to improve the survival rate, reduce the symptoms of heart failure such as breathlessness or leg swelling and reduce the chance of being admitted to the hospital because of heart failure.

This medication may also be used to treat high blood pressure or high aldosterone (a type of hormone) levels.

Eplerenone - Side Effects, Precautions, and Contraindications

What side effects can Eplerenone cause?

  • Passing urine more often
  • Dizziness and lightheadedness
  • Increased potassium levels in your blood
    • Your doctor may monitor your potassium levels and kidney function regularly when you are on this medication. 



  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body


Before taking Eplerenone, what precautions must I follow?

​Inform your healthcare professional if:

  • You are pregnant, planning to become pregnant, or breastfeeding
  • You have any kidney problems

What food or medicine must I avoid when I take Eplerenone?

Some medications may interact with eplerenone and affect their effectiveness or increase the risk of side-effects. However, these medications may also be important for your treatment. Inform your healthcare professional of the other medications you are currently taking. Examples include:

  • Medications for bacterial infections (e.g. clarithromycin, erythromycin)
  • Medications for fungal infections (e.g. itraconazole, ketoconazole)

Eplerenone - Dosage and How to Use

How should Eplerenone be used?

  • You may take this medication with or without food.
  • If you are taking one dose a day, take it in the morning. If you are taking the medicine two times a day, take the second dose before 6pm so that you do not need to wake up often at night to urinate.

What should I do if I miss a dose?


What should I do if I overdose?

Eplerenone - Handling

How should I handle Eplerenone safely?

Eplerenone - Storage

How should I store Eplerenone?


​Throw away all expired medications

How should I dispose of Eplerenone safely?


Eplerenone - Additional Information

  • Updated on Wednesday, July 31, 2019


    Find Your Medicines