Hacking the President’s DNA

Miles Donovan










The scenario we’ve just sketched may sound like nothing but science fiction—and, indeed, it does contain a few futuristic leaps. Many members of the scientific community would say our time line is too fast. But consider that since the beginning of this century, rapidly accelerating technology has shown a distinct tendency to turn the impossible into the everyday in no time at all. Last year, IBM’s Watson, an artificial intelligence, understood natural language well enough to whip the human champion Ken Jennings on Jeopardy. As we write this, soldiers with bionic limbs are returning to active duty, and autonomous cars are driving down our streets. Yet most of these advances are small in comparison with the great leap forward currently under way in the biosciences—a leap with consequences we’ve only begun to imagine.

Personalized bioweapons are a subtler and less catastrophic threat than accidental plagues or WMDs. Yet they will likely be unleashed much more readily.







If you really want to understand what’s happening in the biosciences, then you need to understand the rate at which information technology is accelerating. In 1965, Gordon Moore famously realized that the number of integrated-circuit components on a computer chip had been doubling roughly every year since the invention of the integrated circuit in the late 1950s. Moore, who would go on to co-found Intel, predicted that the trend would continue “for at least 10 years.” He was right. The trend did continue for 10 years, and 10 more after that. All told, his observation has remained accurate for five decades, becoming so durable that it’s now known as “Moore’s Law” and used by the semi-conductor industry as a guide for future planning.

Moore’s Law originally stated that every 12 months (it is now 24 months), the number of transistors on an integrated circuit will double—an example of a pattern known as “exponential growth.” While linear growth is a slow, sequential proposition (1 becomes 2 becomes 3 becomes 4, etc.), exponential growth is an explosive doubling (1 becomes 2 becomes 4 becomes 8, etc.) with a transformational effect. In the 1970s, the most powerful supercomputer in the world was a Cray. It required a small room to hold it and cost roughly $8 million. Today, the iPhone in your pocket is more than 100 times faster and more than 12,000 times cheaper than a Cray. This is exponential growth at work.

In the years since Moore’s observation, scientists have discovered that the pattern of exponential growth occurs in many other industries and technologies. The amount of Internet data traffic in a year, the number of bytes of computer data storage available per dollar, the number of digital-camera pixels per dollar, and the amount of data transferable over optical fiber are among the dozens of measures of technological progress that follow this pattern. In fact, so prevalent is exponential growth that researchers now suspect it is found in all information-based technology—that is, any technology used to input, store, process, retrieve, or transmit digital information.

Over the past few decades, scientists have also come to see that the four letters of the genetic alphabet—A (adenine), C (cytosine), G (guanine), and T (thymine)—can be transformed into the ones and zeroes of binary code, allowing for the easy, electronic manipulation of genetic information. With this development, biology has turned a corner, morphing into an information-based science and advancing exponentially. As a result, the fundamental tools of genetic engineering, tools designed for the manipulation of life—tools that could easily be co-opted for destructive purposes—are now radically falling in cost and rising in power. Today, anyone with a knack for science, a decent Internet connection, and enough cash to buy a used car has what it takes to try his hand at bio-hacking.

These developments greatly increase several dangers. The most nightmarish involve bad actors creating weapons of mass destruction, or careless scientists unleashing accidental plagues—very real concerns that urgently need more attention. Personalized bioweapons, the focus of this story, are a subtler and less catastrophic threat, and perhaps for that reason, society has barely begun to consider them. Yet once available, they will, we believe, be put into use much more readily than bioweapons of mass destruction. For starters, while most criminals might think twice about mass slaughter, murder is downright commonplace. In the future, politicians, celebrities, leaders of industry—just about anyone, really—could be vulnerable to attack-by-disease. Even if fatal, many such attacks could go undetected, mistaken for death by natural causes; many others would be difficult to pin on a suspect, especially given the passage of time between exposure and the appearance of symptoms.

Moreover—as we’ll explore in greater detail—these same scientific developments will pave the way, eventually, for an entirely new kind of personal warfare. Imagine inducing extreme paranoia in the CEO of a large corporation so as to gain a business advantage, for example; or—further out in the future—infecting shoppers with the urge to impulse-buy.

We have chosen to focus this investigation mostly on the president’s bio-security, because the president’s personal welfare is paramount to national security—and because a discussion of the challenges faced by those charged with his protection will illuminate just how difficult (and different) “security” will be, as biotechnology continues to advance.

direct assault against the president’s genome requires first being able to decode genomes. Until recently, this was no simple matter. In 1990, when the U.S. Department of Energy and the National Institutes of Health announced their intention to sequence the 3 billion base pairs of the human genome over the next 15 years, it was considered the most ambitious life-sciences project ever undertaken. Despite a budget of $3 billion, progress did not come quickly. Even after years of hard work, many experts doubted that the time and money budgeted would be enough to complete the job.

This started to change in 1998, when the entrepreneurial biologist J. Craig Venter and his company, Celera, got into the race. Taking advantage of the exponential growth in biotechnology, Venter relied on a new generation of gene sequencers and a novel, computer-intensive approach called shotgun sequencing to deliver a draft human genome (his own) in less than two years, for $300 million.

Venter’s achievement was stunning; it was also just the beginning. By 2007, just seven years later, a human genome could be sequenced for less than $1 million. In 2008, some labs would do it for $60,000, and in 2009, $5,000. This year, the $1,000 barrier looks likely to fall. At the current rate of decline, within five years, the cost will be less than $100. In the history of the world, perhaps no other technology has dropped in price and increased in performance so dramatically.

Still, it would take more than just a gene sequencer to build a personally targeted bioweapon. To begin with, prospective attackers would have to collect and grow live cells from the target (more on this later), so cell-culturing tools would be a necessity. Next, a molecular profile of the cells would need to be generated, involving gene sequencers, micro-array scanners, mass spectrometers, and more. Once a detailed genetic blueprint had been built, the attacker could begin to design, build, and test a pathogen, which starts with genetic databases and software and ends with virus and cell-culture work. Gathering the equipment required to do all of this isn’t trivial, and yet, as researchers have upgraded to new tools, as large companies have merged and consolidated operations, and as smaller shops have run out of money and failed, plenty of used lab equipment has been dumped onto the resale market. New, the requisite gear would cost well over $1 million. On eBay, it can be had for as little as $10,000. Strip out the analysis equipment—since those processes can now be outsourced—and a basic cell-culture rig can be cobbled together for less than $1,000. Chemicals and lab supplies have never been easier to buy; hundreds of Web resellers take credit cards and ship almost anywhere.

Biological knowledge, too, is becoming increasingly democratized. Web sites like JoVE (Journal of Visualized Experiments) provide thousands of how-to videos on the techniques of bioscience. MIT offers online courses. Many journals are going open-access, making the latest research, complete with detailed sections on materials and methods, freely available. If you wanted a more hands-on approach to learning, you could just immerse yourself in any of the dozens of do-it-yourself-biology organizations, such as Genspace and BioCurious, that have lately sprung up to make genetic engineering into something of a hobbyist’s pursuit. Bill Gates, in a recent interview, told a reporter that if he were a kid today, forget about hacking computers: he’d be hacking biology. And for those with neither the lab nor the learning, dozens of Contract Research and Manufacturing Services (known as CRAMS) are willing to do much of the serious science for a fee.

From the invention of genetic engineering in 1972 until very recently, the high cost of equipment, and the high cost of education to use that equipment effectively, kept most people with ill intentions away from these technologies. Those barriers to entry are now almost gone. “Unfortunately,” Secretary Clinton said in a December 7, 2011, speech to the Biological and Toxin Weapons Convention Review Conference, “the ability of terrorists and other non-state actors to develop and use these weapons is growing. And therefore, this must be a renewed focus of our efforts … because there are warning signs, and they are too serious to ignore.”























In 2005, as part of its preparation for this threat, the FBI hired Edward You, a cancer researcher at Amgen and formerly a gene therapist at the University of Southern California’s Keck School of Medicine. You, now a supervisory special agent in the Weapons of Mass Destruction Directorate within the FBI’s Biological Countermeasures Unit, knew that biotechnology had been expanding too quickly for the bureau to keep pace, so he decided the only way to stay ahead of the curve was to develop partnerships with those at the leading edge. “When I got involved,” You says, “it was pretty clear the FBI wasn’t about to start playing Big Brother to the life sciences. It’s not our mandate, and it’s not possible. All the expertise lies in the scientific community. Our job has to be outreach education. We need to create a culture of security in the synbio community, of responsible science, so the researchers themselves understand that they are the guardians of the future.”

Toward that end, the FBI started hosting free bio-security conferences, stationed WMD outreach coordinators in 56 field offices to network with the synbio community (among other responsibilities), and became an iGEM partner. In 2006, after reporters at The Guardian successfully mail-ordered a crippled fragment of the genome for the smallpox virus, suppliers of genetic materials decided to develop self-policing guidelines. According to You, the FBI sees the organic emergence of these guidelines as proof that its community-based policing approach is working. However, we are not so sure these new rules do much besides guarantee that a pathogen isn’t sent to a P.O. box.

In any case, much more is necessary. An October 2011 report by the WMD Center, a nonprofit organization led by former Senators Bob Graham (a Democrat) and Jim Talent (a Republican), said a terrorist-sponsored WMD strike somewhere in the world was probable by the end of 2013—and that the weapon would most likely be biological. The report specifically highlighted the dangers of synthetic biology:

As DNA synthesis technology continues to advance at a rapid pace, it will soon become feasible to synthesize nearly any virus whose DNA sequence has been decoded … as well as artificial microbes that do not exist in nature. This growing ability to engineer life at the molecular level carries with it the risk of facilitating the development of new and more deadly biological weapons.

Malevolent non-state actors are not the only danger to consider. Forty nations now host synbio research, China among them. The Beijing Genomics Institute, founded in 1999, is the largest genomic-research organization in the world, sequencing the equivalent of roughly 700,000 human genomes a year. (In a recent Science article, BGI claimed to have more sequencing capacity than all U.S. labs combined.) Last year, during a German E. coli outbreak, when concerns were raised that the disease was a new, particularly deadly strain, BGI sequenced the culprit in just three days. To put that in perspective, SARS—the deadly pneumonia variant that panicked the world in 2003—was sequenced in 31 days. And BGI appears poised to move beyond DNA sequencing and become one of the foremost DNA synthesizers as well.

BGI hires thousands of bright young researchers each year. The training is great, but the wages are reportedly low. This means that many of its talented synthetic biologists may well be searching for better pay and greener pastures each year, too. Some of those jobs will undoubtedly appear in countries not yet on the synbio radar. Iran, North Korea, and Pakistan will almost certainly be hiring.

In the run-up to Barack Obama’s inauguration, threats against the incoming president rose markedly. Each of those threats had to be thoroughly investigated. In his book on the Secret Service, Ronald Kessler writes that in January 2009, for example, when intelligence emerged that the Somalia-based Islamist group al‑Shabaab might try to disrupt Obama’s inauguration, the Secret Service’s mandate for that day became even harder. In total, Kessler reports, the Service coordinated some 40,000 agents and officers from 94 police, military, and security agencies. Bomb-sniffing dogs were deployed throughout the area, and counter-sniper teams were stationed along the parade route. This is a considerable response capability, but in the future, it won’t be enough. A complete defense against the weapons that synbio could make possible has yet to be invented.

The range of threats that the Secret Service has to guard against already extends far beyond firearms and explosive devices. Both chemical and radiological attacks have been launched against government officials in recent years. In 2004, the poisoning of the Ukrainian presidential candidate Viktor Yushchenko involved TCCD, an extremely toxic dioxin compound. Yushchenko survived, but was severely scarred by chemically induced lesions. In 2006, Alexander Litvinenko, a former officer of the Russian security service, was poisoned to death with the radioisotope polonium 210. And the use of bioweapons themselves is hardly unknown; the 2001 anthrax attacks in the United States nearly reached members of the Senate.

The Kremlin, of course, has been suspected of poisoning its enemies for decades, and anthrax has been around for a while. But genetic technologies open the door for a new threat, in which a head of state’s own DNA could be used against him or her. This is particularly difficult to defend against. No amount of Secret Service vigilance can ever fully secure the president’s DNA, because an entire genetic blueprint can now be produced from the information within just a single cell. Each of us sheds millions and millions of cells every day. These can be collected from any number of sources—a used tissue, a drinking glass, a toothbrush. Every time President Obama shakes hands with a constituent, Cabinet member, or foreign leader, he’s leaving an exploitable genetic trail. Whenever he gives away a pen at a bill-signing ceremony, he gives away a few cells too. These cells are dead, but the DNA is intact, allowing for the revelation of potentially compromising details of the president’s biology.

To build a bioweapon, living cells would be the true target (although dead cells may suffice as soon as a decade from now). These are more difficult to recover. A strand of hair, for example, is dead, but if that hair contains a follicle, it also contains living cells. A sample gathered from fresh blood or saliva, or even a sneeze, caught in a discarded tissue, could suffice. Once recovered, these living cells can be cultured, providing a continuous supply of research material.

Even if Secret Service agents were able to sweep up all the shed cells from the president’s current environs, they couldn’t stop the recovery of DNA from the president’s past. DNA is a very stable molecule, and can last for millennia. Genetic material remains present on old clothes, high-school papers—any of the myriad objects handled and discarded long before the announcement of a presidential candidacy. How much attention was dedicated to protecting Barack Obama’s DNA when he was a senator? A community organizer in Chicago? A student at Harvard Law? A kindergartner? And even if presidential DNA were somehow fully locked down, a good approximation of the code could be made from cells of the president’s children, parents, or siblings, living or not.


For the Secret Service, these new vulnerabilities conjure attack scenarios worthy of a Hollywood thriller. Advances in stem-cell research make any living cell transformable into many other cell types, including neurons or heart cells or even in vitro–derived (IVD) “sperm.” Any live cells recovered from a dirty glass or a crumpled napkin could, in theory, be used to manufacture synthetic sperm cells. And so, out of the blue, a president could be confronted by a “former lover” coming forward with DNA evidence of a sexual encounter, like a semen stain on a dress. Sophisticated testing could distinguish an IVD fake sperm from the real thing—they would not be identical—but the results might never be convincing to the lay public. IVD sperm may also someday prove capable of fertilizing eggs, allowing for “love children” to be born using standard in vitro fertilization.

In the hope of mounting the best defense, one option is radical transparency: release the president’s DNA.


The delivery of this sort of biological agent would be very difficult to detect. Viruses are tasteless and odorless and easily aerosolized. They could be hidden in a perfume bottle; a quick dab on the attacker’s wrist in the general proximity of the target is all an assassination attempt would require. If the pathogen were designed to zero in specifically on the president’s DNA, then nobody else would even fall ill. No one would suspect an attack until long after the infection.

Pernicious agents could be crafted to do their damage months or even years after exposure, depending on the goals of the designer. Several viruses are already known to spark cancers. New ones could eventually be designed to infect the brain with, for instance, synthetic schizophrenia, bipolar disorder, or Alzheimer’s. Stranger possibilities exist as well. A disease engineered to amplify the production of cortisol and dopamine could induce extreme paranoia, turning, say, a peace-seeking dove into a warmongering hawk. Or a virus that boosts the production of oxytocin, the chemical likely responsible for feelings of trust, could play hell with a leader’s negotiating abilities. Some of these ideas aren’t new. As far back as 1994, the U.S. Air Force’s Wright Laboratory theorized about chemical-based pheromone bombs.

Of course, heads of state would not be the only ones vulnerable to synbio threats. Al‑Qaeda flew planes into buildings to cripple Wall Street, but imagine the damage an attack targeting the CEOs of a number of Fortune 500 companies could do to the world economy. Forget kidnapping rich foreign nationals for ransom; kidnapping their DNA might one day be enough. Celebrities will face a new kind of stalker. As home-brew biology matures, these technologies could end up being used to “settle” all sorts of disputes, even those of the domestic variety. Without question, we are near the dawn of a brave new world.

How might we protect the president in the years ahead, as biotech continues to advance? Despite the acceleration of readily exploitable biotechnology, the Secret Service is not powerless. Steps can be taken to limit risks. The agency would not reveal what defenses are already in place, but establishing a crack scientific task force within the agency to monitor, forecast, and evaluate new biotechnological risks would be an obvious place to start. Deploying sensing technologies is another possibility. Already, bio-detectors have been built that can sense known pathogens in less than three minutes. These can get better—a lot better—but even so, they might be limited in their effectiveness. Because synbio opens the door to new, finely targeted pathogens, we’d need to detect that which we’ve never seen before. In this, however, the Secret Service has a big advantage over the Centers for Disease Control and Prevention or the World Health Organization: its principal responsibility is the protection of one specific person. Bio-sensing technologies could be developed around the president’s actual genome. We could use his living cells to build an early-warning system with molecular accuracy.

Cultures of live cells taken from the president could also be kept at the ready—the biological equivalent to data backups. The Secret Service reportedly already carries several pints of blood of the president’s type in his motorcade, in case an emergency transfusion becomes necessary. These biological backup systems could be expanded to include “clean DNA”—essentially, verified stem-cell libraries that would allow bone-marrow transplantation or the enhancement of antiviral or antimicrobial capabilities. As so-called tissue-printing technologies improve, the president’s cells could even be turned, one day, into ready-made standby replacement organs.

Yet even if the Secret Service were to implement some or all of these measures, there is no guarantee that the presidential genome could be completely protected. Anyone truly determined to get the president’s DNA would probably succeed, no matter the defenses. And the Secret Service might have to accept that it can’t fully counter all bio-threats, any more than it can guarantee that the president will never catch a cold.

In the hope of mounting the best defense against an attack, one possible solution—not without its drawbacks—is radical transparency: release the president’s DNA and other relevant biological data, either to a select group of security-cleared bioscience researchers or (the far more controversial step) to the public at large. These ideas may seem counterintuitive, but we have come to believe that open-sourcing this problem—and actively engaging the American public in the challenge of protecting its leader—might turn out to be the best defense.

One practical reason is cost. Any in-house protection effort would be exceptionally pricey. Certainly, considering what’s at stake, the country would bear the expense, but is that the best solution? After all, over the past five years, DIY Drones, a nonprofit online community of autonomous aircraft hobbyists (working for free, in their spare time), produced a $300 unmanned aerial vehicle with 90 percent of the functionality of the military’s $35,000 Raven. This kind of price reduction is typical of open-sourced projects.

Moreover, conducting bio-security in-house means attracting and retaining a very high level of talent. This puts the Secret Service in competition with industry—a fiscally untenable position—and with academia, which offers researchers the freedom to tackle a wider range of interesting problems. But by tapping the collective intelligence of the life-sciences community, the agency would enlist the help of the group best prepared to address this problem, at no cost.

Open-sourcing the president’s genetic information to a select group of security-cleared researchers would bring other benefits as well. It would allow the life sciences to follow in the footsteps of the computer sciences, where “red-team exercises,” or “penetration testing,” are extremely common practices. In these exercises, the red team—usually a group of faux-black-hat hackers—attempts to find weaknesses in an organization’s defenses (the blue team). A similar testing environment could be developed for biological war games.

One of the reasons this kind of practice has been so widely instituted in the computer world is that the speed of development far exceeds the ability of any individual security expert, working alone, to keep pace. Because the life sciences are now advancing faster than computing, little short of an internal Manhattan Project–style effort could put the Secret Service ahead of this curve. The FBI has far greater resources at its disposal than the Secret Service; almost 36,000 people work there, for instance, compared with fewer than 7,000 at the Secret Service. Yet Edward You and the FBI reviewed this same problem and concluded that the only way the bureau could keep up with biological threats was by involving the whole of the life-sciences community.

So why go further? Why take the radical step of releasing the president’s genome to the world instead of just to researchers with security clearances? For one thing, as the U.S. State Department’s DNA-gathering mandate makes clear, the surreptitious collection of world leaders’ genetic material has already begun. It would not be surprising if the president’s DNA has already been collected and analyzed by America’s adversaries. Nor is it unthinkable, given our increasingly nasty party politics, that the president’s domestic political opponents are in possession of his DNA. In the November 2008 issue of The New England Journal of Medicine, Robert C. Green and George J. Annas warned of this possibility, writing that by the 2012 election, “advances in genomics will make it more likely that DNA will be collected and analyzed to assess genetic risk information that could be used for or, more likely, against presidential candidates.” It’s also not hard to imagine the rise of a biological analog to the computer-hacking group Anonymous, intent on providing a transparent picture of world leaders’ genomes and medical histories. Sooner or later, even without open-sourcing, a president’s genome will end up in the public eye.

So the question becomes: Is it more dangerous to play defense and hope for the best, or to go on offense and prepare for the worst? Neither choice is terrific, but even beyond the important issues of cost and talent attraction, open-sourcing—as Claire Fraser, the director of the Institute for Genome Sciences at the University of Maryland School of Medicine, points out—“would level the playing field, removing the need for intelligence agencies to plan for every possible worst-case scenario.”

It would also let the White House preempt the media storm that would occur if someone else leaked the president’s genome. In addition, constant scrutiny of the president’s genome would allow us to establish a baseline and track genetic changes over time, producing an exceptional level of early detection of cancers and other metabolic diseases. And if such diseases were found, an open-sourced genome could likewise accelerate the development of personalized therapies.

The largest factor to consider is time. In 2008, some 14,000 people were working in U.S. labs with access to seriously pathogenic materials; we don’t know how many tens of thousands more are doing the same overseas. Outside those labs, the tools and techniques of genetic engineering are accessible to many other people. Back in 2003, a panel of life-sciences experts, convened by the National Academy of Sciences for the CIA’s Strategic Assessments Group, noted that because the processes and techniques needed for the development of advanced bio agents can be used for good or for ill, distinguishing legitimate research from research for the production of bioweapons will soon be extremely difficult. As a result, “most panelists argued that a qualitatively different relationship between the government and life sciences communities might be needed to most effectively grapple with the future BW threat.”

In our view, it’s no longer a question of “might be.” Advances in biotechnology are radically changing the scientific landscape. We are entering a world where imagination is the only brake on biology, where dedicated individuals can create new life from scratch. Today, when a difficult problem is mentioned, a commonly heard refrain is There’s an app for that. Sooner than you might believe, an app will be replaced by an organism when we think about the solutions to many problems. In light of this coming synbio revolution, a wider-ranging relationship between scientists and security organizations—one defined by open exchange, continual collaboration, and crowd-sourced defenses—may prove the only way to protect the president. And, in the process, the rest of us.

Andrew Hessel is a faculty member and a former co-chair of bioinformatics and biotechnology at Singularity University, and a fellow at the Institute for Science, Society, and Policy at the University of Ottawa. Marc Goodman investigates the impact of advancing technologies on global security, advising Interpol and the U.S. government. He is the founder of the Future Crimes Institute and Chair for Policy, Law & Ethics at Silicon Valley's Singularity University. Steven Kotler is a New York Times–best-selling author and an award-winning journalist.
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