immune system

Antibody-mediated immune mechanisms

Protective attachment to antigens

Many pathogenic microorganisms and toxins can be rendered harmless by the simple attachment of antibodies. For example, some harmful bacteria, such as those that cause diphtheria and tetanus, release toxins that poison essential body cells. Antibodies, especially IgG, that combine with such toxins neutralize them. Also susceptible to simple antibody attachment are the many infectious microbes—including all viruses and some bacteria and protozoans—that live within the body cells. These pathogens bear special molecules that they use to attach themselves to the host cells so that they can penetrate and invade them. Antibodies can bind to these molecules to prevent invasion. Antibody attachment also can immobilize bacteria and protozoans that swim by means of whiplike flagella. In these instances antibodies protect simply by combining with the repeating protein units that make up these structures, although they do not kill or dispose of the microbes. The actual destruction of microbes involves phagocytosis by granulocytes and macrophages, and this is greatly facilitated by the participation of the complement system.

Activation of the complement system

complement: activation pathways [Credit: Encyclopædia Britannica, Inc.]Complement is a term used to denote a group of more than 30 proteins that act ... (200 of 14,842 words)

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