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Purinergic receptor P2Y, G-protein coupled, 12
Symbol(s) P2RY12; ADPG-R; HORK3; P2T(AC); P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; SP1999
External IDs OMIM: 600515 MGI1918089 Homologene11260
Human Mouse Entrez 64805 70839 Ensembl ENSG00000169313 ENSMUSG00000036353 Uniprot Q9H244 Q546L4 Refseq NM_022788 (mRNA)
NP_073625 (protein)
NM_027571 (mRNA)
NP_081847 (protein)
Location Chr 3: 152.54 - 152.59 Mb Chr 3: 59.3 - 59.35 Mb
Pubmed search [1] [2]

In the field of molecular biology, the P2Y12 protein is a chemoreceptor for adenosine diphosphate (ADP) and is found on the cell surface of blood platelet cells.[1][2]

The P2Y12 protein belongs to a group of G protein-coupled purinergic receptors[3] and is an important regulator in blood platelet coagulation.[4]

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.[5]

Clinical significance

The drug clopidogrel binds to this receptor and is marketed as a platelet anticoagulant.[1] In an April 2006 article, a team of researchers published a study of the role of platelet-transported serotonin in liver regeneration in which this method of platelet anticoagulant therapy was used.[6]


  1. 1.0 1.1 Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, Conley PB (2001). Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409 (6817): 202-7.
  2. Nicholas RA (2001). Identification of the P2Y(12) receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides. Mol. Pharmacol. 60 (3): 416-20.
  3. Murugappa S, Kunapuli SP (2006). The role of ADP receptors in platelet function. Front. Biosci. 11: 1977-86.
  4. Dorsam RT, Kunapuli SP (2004). Central role of the P2Y12 receptor in platelet activation. J. Clin. Invest. 113 (3): 340-5.
  5. Entrez Gene: P2RY12 purinergic receptor P2Y, G-protein coupled, 12.
  6. Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Bader M, Clavien PA (2006). Platelet-derived serotonin mediates liver regeneration. Science 312 (5770): 104-7.

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