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66,
35,
67,
36,
68,
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34,
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281,
320,
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342,
247,
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390,
1318,
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510,
187,
12467,
281,
5386,
247,
1873,
310,
2634,
1109,
65,
19722,
15,
187,
187,
93,
34,
66,
35,
67,
36,
68,
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1040,
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13,
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568,
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15,
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65,
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77,
62,
65,
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510,
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65,
14,
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65,
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417,
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15,
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93,
65,
92,
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65,
1040,
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247,
873,
273,
10165,
323,
247,
2424,
3923,
4500,
15,
187,
93,
65,
14
] | . Instructions
for performing these tasks from the Administration Console are provided
in the Administration Console online help.
|link:../security-guide/toc.html#GSSCG[Security Guide] |Provides instructions for configuring and
administering GlassFish Server security.
|link:../application-deployment-guide/toc.html#GSDPG[Application Deployment Guide] |Explains how to assemble and
deploy applications to the GlassFish Server and provides information
about deployment descriptors.
|link:../application-development-guide/toc.html#GSDVG[Application Development Guide] |Explains how to create and
implement Java Platform, Enterprise Edition (Java EE platform)
applications that are intended to run on the GlassFish Server. These
applications follow the open Java standards model for Java EE components
and application programmer interfaces (APIs). This guide provides
information about developer tools, security, and debugging.
|link:../add-on-component-development-guide/toc.html#GSACG[Add-On Component Development Guide] |Explains how to use
published interfaces of GlassFish Server to develop add-on components
for GlassFish Server. This document explains how to perform only those
tasks that ensure that the add-on component is suitable for GlassFish
Server.
|link:../embedded-server-guide/toc.html#GSESG[Embedded Server Guide] |Explains how to run applications in
embedded GlassFish Server and to develop applications in which GlassFish
Server is embedded.
|link:../ha-administration-guide/toc.html#GSHAG[High Availability Administration Guide] |Explains how to
configure GlassFish Server to provide higher availability and
scalability through failover and load balancing.
|link:../performance-tuning-guide/toc.html#GSPTG[Performance Tuning Guide] |Explains how to optimize the
performance of GlassFish Server.
|link:../troubleshooting-guide/toc.html#GSTSG[Troubleshooting Guide] |Describes common problems that you
might encounter when using GlassFish Server and explains how to solve
them.
|link:../error-messages-reference/toc.html#GSEMR[Error Message Reference] |Describes error messages that you
might encounter when using GlassFish Server.
|link:../reference-manual/toc.html#GSRFM[Reference Manual] |Provides reference information in man
page format for GlassFish Server administration commands, utility
commands, and related concepts.
|link:../../openmq/mq-release-notes/toc.html#GMRLN[Message Queue Release Notes] |Describes new features,
compatibility issues, and existing bugs for Open Message Queue.
|link:../../openmq/mq-tech-over/toc.html#GMTOV[Message Queue Technical Overview] |Provides an introduction
to the technology, concepts, architecture, capabilities, and features of
the Message Queue messaging service.
|link:../../openmq/mq-admin-guide/toc.html#GMADG[Message Queue Administration Guide] |Explains how to set up
and manage a Message Queue messaging system.
|link:../../openmq/mq-dev-guide-jmx/toc.html#GMJMG[Message Queue Developer's Guide for JMX Clients] |Describes
the application programming interface in Message Queue for
programmatically configuring and monitoring Message Queue resources in
conformance with the Java Management Extensions (JMX).
|link:../../openmq/mq-dev-guide-java/toc.html#GMJVG[Message Queue Developer's Guide for Java Clients] |Provides
information about concepts and procedures for developing Java messaging
applications (Java clients) that work with GlassFish Server.
|link:../../openmq/mq-dev-guide-c/toc.html#GMCCG[Message Queue Developer's Guide for C Clients] |Provides
programming and reference information for developers working with
Message Queue who want to use the C language binding to the Message
Queue messaging service to send, receive, and process Message Queue
messages.
|=======================================================================
[[GSACG00080]][[giprl]]
[[related-documentation]]
Related Documentation
~~~~~~~~~~~~~~~~~~~~~
The following tutorials explain how to develop Java EE applications:
* http://docs.oracle.com/javaee/7/firstcup/doc/home.html[Your First Cup:
An Introduction to the Java EE Platform]
(`http://docs.oracle.com/javaee/7/firstcup/doc/home.html`). For beginning
Java EE programmers, this short tutorial explains the entire process for
developing a simple enterprise application. The sample application is a
web application that consists of a component that is based on the
Enterprise JavaBeans specification, a JAX-RS web service, and a
JavaServer Faces component for the web front end.
* http://docs.oracle.com/javaee/7/tutorial/doc/home.html[The Java EE 7
Tutorial] (`http://docs.oracle.com/javaee/7/tutorial/doc/home.html`).
This comprehensive tutorial explains how to use Java EE 7 platform
technologies and APIs to develop Java EE applications.
Javadoc tool reference documentation for packages that are provided with
GlassFish Server is available as follows.
* The API specification for version 7 of Java EE is located at
`http://docs.oracle.com/javaee/7/api/`.
* The API specification for GlassFish Server 4.0, including Java EE 7
platform packages and nonplatform packages that are specific to the
GlassFish Server product, is located at
`http://glassfish.java.net/nonav/docs/v3/api/`.
Additionally, the
http://www.oracle.com/technetwork/java/javaee/tech/index.html[Java EE
Specifications]
(`http://www.oracle.com/technetwork/java/javaee/tech/index.html`) might
be useful.
For information about creating enterprise applications in the NetBeans
Integrated Development Environment (IDE), see the
http://www.netbeans.org/kb/[NetBeans Documentation, Training & Support
page] (`http://www.netbeans.org/kb/`).
For information about the Java DB database for use with the GlassFish
Server, see the
http://www.oracle.com/technetwork/java/javadb/overview/index.html[Java
DB product page]
(`http://www.oracle.com/technetwork/java/javadb/overview/index.html`).
The Java EE Samples project is a collection of sample applications that
demonstrate a broad range of Java EE technologies. The Java EE Samples
are bundled with the Java EE Software Development Kit (SDK) and are also
available from the http://glassfish-samples.java.net/[Java EE Samples
project page] (`http://glassfish-samples.java.net/`).
[[GSACG00081]][[fwbkx]]
[[typographic-conventions]]
Typographic Conventions
~~~~~~~~~~~~~~~~~~~~~~~
The following table describes the typographic changes that are used in
this book.
[width="100%",cols="<14%,<37%,<49%",options="header",]
|=======================================================================
|Typeface |Meaning |Example
|`AaBbCc123` |The names of commands, files, and directories, and
onscreen computer output a|
Edit your `.login` file.
Use `ls` `a` to list all files.
`machine_name% you have mail.`
|`AaBbCc123` |What you type, contrasted with onscreen computer output a|
`machine_name%` `su`
`Password:`
|AaBbCc123 |A placeholder to be replaced with a real name or value |The
command to remove a file is `rm` filename.
|AaBbCc123 |Book titles, new terms, and terms to be emphasized (note
that some emphasized items appear bold online) a|
Read Chapter 6 in the User's Guide.
A cache is a copy that is stored locally.
Do not save the file.
|=======================================================================
[[GSACG00082]][[fquvc]]
[[symbol-conventions]]
Symbol Conventions
~~~~~~~~~~~~~~~~~~
The following table explains symbols that might be used in this book.
[width="100%",cols="<10%,<26%,<28%,<36%",options="header",]
|=======================================================================
|Symbol |Description |Example |Meaning
|`[ ]` |Contains optional arguments and command options. |`ls [-l]` |The
`-l` option is not required.
|`{ \| }` |Contains a set of choices for a required command option.
|`- |
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] | to whom he addressed his question, "That thing the Mahlessa freed you from. Did it find him or did he find it?"
"The Sentar had already been reborn before I was . . . taken," Kiral said. "Your son had been one of those who remade it, finding others of similar mind, hungry for blood and seeking to justify their cruelty. He hated the Mahlessa for his disgrace, claiming he could have killed the greatest of the Merim Her but for her weakness, for she was old, and corrupted by the ages. But they were few in number and their plans chaotic, being possessed of a shared madness. To fulfil their mission the Sentar needed leadership, and found it in me." She grimaced, her voice taking on a note of apology, "You would always have had to kill him, Tahlessa. Only truth can be heard from the gods."
• • •
He was roused by one of the wolves, a huge male with an insistent tongue and foul-smelling breath. It jumped back a little as Vaelin jerked awake, dagger in hand, angling its head at him in curiosity before voicing an impatient yelp.
"What is it?" Dahrena groaned at his side, her pale and bleary-eyed face appearing above the furs.
"I think someone has finally come to welcome us," he said, reaching for his boots.
Astorek, Kiral and Wise Bear waited at the foot of the south-facing slope, a line of wolves spread out before them and a cluster of spear-hawks overhead. "How many?" Vaelin asked, coming to Kiral's side.
"Just one."
Vaelin peered into the distance, picking out a single figure, hooded and cloaked, striding towards them without any apparent alarm at the cloud of spear-hawks descending to circle him at head height. Vaelin went forward to welcome him as he came to a halt before the line of wolves, a man of average height, broad but not overly muscular, drawing his hood back to reveal lean but deeply lined features, and eyes that spoke of a depth of experience Vaelin now knew to be vast.
"Ah," said Erlin. "I thought it might be you."
## CHAPTER SIX
Reva
She awoke to pain, a fierce, piercing ache in her right hand, banishing the blackness with a persistent, pulsing agony. She groaned, shaking her hand, but the pain flared rather than faded. She winced as her eyes opened, sunlight sending a bolt of white fire into her brain. For a time all she could see was a faint yellow blur, her ears constantly assaulted by a roaring hiss. Forcing herself to blink, she managed to focus, the yellow blur resolving into a beach, the roar the rushing waves that jostled her, and the pain in her hand the result of a small red crab attempting to eat her thumb.
She pinched its claw and tugged it free, tossing it into the surf, gritting her teeth against the sting of salt in the wound but finding herself oddly grateful for the sensation; it confirmed she was, much to her surprise, alive. Barely able to move and lying prostrate on a beach whilst waves pounded her, but still undeniably alive.
_Why?_ she asked the Father, more curious than angry. _You cannot think I deserve to live. You cannot reward one whose lie has killed so many._
The voice was so unexpected, and shocking in its volume, she thought for an instant the Father had actually deigned to respond. Her heart calmed when she realised the voice called out words she couldn't understand, her still-cloudy vision finding the owner, a hulking shape in black labouring through the surf towards her. The details of his garb became clear as he neared, a black leather jerkin, a silver medallion worn around the neck, and a whip on his belt. _Overseer._
She let him take hold of her hair and haul her free of the water, keeping her features slack and uncomprehending as his brutish face came closer, eyes moving over her in expert appraisal. He called over his shoulder to an unseen companion, confirming he wasn't alone. She kept her eyes half-open as he dragged her from the sea, counting six more shapes standing on the beach, and many more lying prostrate and unmoving.
The overseer dumped her on the sand where she forced herself to remain limp and immobile, breathing deep but soft, gathering strength. They made the mistake of waiting several minutes before returning to examine their catch, the overseer who had found her pulling her onto her back as his companions gathered round. She counted two with spears as her head lolled to one side, the others with short swords. The overseer pulled up her blouse, revealing her breasts as he voiced a question to his companions. There were a few murmurs of agreement, one of them adding something with an appreciative cackle.
"My friend . . . like you," the overseer said in broken Realm Tongue, taking hold of her face and turning it so she could see his leer. "Want to . . . fuck you. Might lower the price . . . But I owe him. You . . . want fucked, pretty thing?"
It was really the smile that killed him, not so much the blow, making him frown in puzzlement at her welcoming, lustful grin, drawing back in surprise just enough to expose his throat. Vaelin had taught her the blow; the priest's lessons in unarmed combat had never been so thorough, nor so effective in practice. Her stiff fingers drove into the overseer's neck with enough force to crush his larynx, leaving him writhing on the sand, bloody froth gouting from his mouth. Reva rolled on the sand, dodging a plunging spear-point then grabbing the haft before its owner could withdraw for another try. She flicked a kick into his face, sending him reeling, then surged to her feet with his spear in her hands.
She whirled as they closed, the spear-point slashing the disarmed spearman across the eyes, another the face. The second spearman came at her with an overextended thrust, indicating a level of expertise best confined to abusing helpless captives. She parried the thrust without difficulty, deflecting the spear with the haft of her own and spinning to slam the blunt end into the back of his neck which snapped with a gratifying crack.
She stood watching the others as they dithered, casting wary glances at the man she had blinded, screaming as blood seeped through the hands he held to his face. "Come on!" she whispered as they exchanged uncertain glances. "You cannot think I deserve to live."
A horn sounded somewhere close by and Reva's eyes found a group of horsemen cresting the dunes a few hundred paces distant. She turned to see more riders approaching from the north end of the beach. Any thought she might soon be rescued faded at the sight of the slavers' evident relief.
The lead rider pulled up next to the body of the overseer with the crushed larynx. The riders differed from other Volarians Reva had seen, clad in red breastplates and greaves. She would have taken them for Kuritai but for the patent amusement on the leader's face as he regarded the overseer's corpse, an amusement shared by the thirty or so riders at his back.
The slavers greeted the red-armoured man with a babble of outrage, suddenly less cowed now there were other eyes to witness the scene. The rider ignored them, shifting his gaze to Reva, his grin growing wider. He held up a hand to silence the slavers then asked a question, raising his eyebrows at the response, the slaver with the slashed face seeking to staunch the blood with a rag as he gesticulated at her, voice shrill with fury.
The man in red armour, however, seemed unmoved by their entreaties, reclining in his saddle and nodding at Reva as he voiced a short command. The slavers' confidence visibly waned on hearing his words, casting wary glances in her direction, fidgeting in uncertainty. The rider spoke again, voicing a single word, the other riders all drawing swords with identical speed and fluency. The leader pointed his own sword at the slavers then at Reva, repeating his first command with slow deliberation.
The slavers, now pale of face and shrinking from the many blades surrounding them, began to advance towards Reva in a slow crouch. She saw little point in prolonging the encounter, choosing the tallest and sending the spear into the centre of his chest, then sprinting forward, rolling under the wild slashes of the remaining slavers to claim his sword. After that, the others offered no more challenge than a light practice.
• • •
Crouched in her chains in the back of a caged wagon, two of the red-armoured Volarians standing close by, she forced herself to watch as the other captives were inspected. She had managed to scar one of them back on the beach, throwing her sword at the first to come close. He dodged with an uncanny swiftness, but not before the spinning blade had left a long cut on his jaw. She had expected death to follow quickly but the scarred man seemed to find the event as amusing as his companions. They were |
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] | , and countless other facets of the film are drawn from all over the continent and its diaspora, in a science-fiction celebration of the imaginary country of Wakanda, a high-tech utopia that is a fictive manifestation of African potential unfettered by slavery and colonialism.
But it is first and foremost an African American love letter, and as such it is consumed with The Void, the psychic and cultural wound caused by the Trans-Atlantic slave trade, the loss of life, culture, language, and history that could never be restored. It is the attempt to penetrate The Void that brought us Alex Haley’s Roots, that draws thousands of African Americans across the ocean to visit West Africa every year, that left me crumpled on the rocks outside the Door of No Return at Gorée Island’s slave house as I stared out over a horizon that my ancestors might have traversed once and forever. Because all they have was lost to The Void, I can never know who they were, and neither can anyone else.
In Cyprus, Estonia, the United Arab Emirates, and elsewhere, passports can now be bought and sold.
“If you believe you are a citizen of the world, you are a citizen of nowhere. You don’t understand what citizenship means,” the British prime minister, Theresa May, declared in October 2016. Not long after, at his first postelection rally, Donald Trump asserted, “There is no global anthem. No global currency. No certificate of global citizenship. We pledge allegiance to one flag and that flag is the American flag.” And in Hungary, Prime Minister Viktor Orbán has increased his national-conservative party’s popularity with statements like “all the terrorists are basically migrants” and “the best migrant is the migrant who does not come.”
Citizenship and its varying legal definition has become one of the key battlegrounds of the 21st century, as nations attempt to stake out their power in a G-Zero, globalized world, one increasingly defined by transnational, borderless trade and liquid, virtual finance. In a climate of pervasive nationalism, jingoism, xenophobia, and ever-building resentment toward those who move, it’s tempting to think that doing so would become more difficult. But alongside the rise of populist, identitarian movements across the globe, identity itself is being virtualized, too. It no longer needs to be tied to place or nation to function in the global marketplace.
Deputy Attorney General Ron Rosenstein flew to Seattle for a press conference at which he announced little, but may have said a great deal.
Back in the fall of 2001, exactly one month after the 9/11 attacks, a lawyer in Seattle named Tom Wales was murdered as he worked alone at his home computer at night. Someone walked into the yard of Wales’s house in the Queen Anne Hill neighborhood of Seattle, careful to avoid sensors that would have set off flood lights in the yard, and fired several times through a basement window, hitting Wales as he sat at his desk. Wales survived long enough to make a call to 911 and died soon afterwards. He was 49, divorced, with two children in their 20s.
The crime was huge and dismaying news in Seattle, where Wales was a prominent, respected, and widely liked figure. As a young lawyer in the early 1980s he had left a potentially lucrative path with a New York law firm to come to Seattle and work as an assistant U.S. attorney, or federal prosecutor. That role, which he was still performing at the time of his death, mainly involved prosecuting fraud cases. In his off-duty hours, Wales had become a prominent gun-control advocate. From the time of his death onward, the circumstances of the killing—deliberate, planned, nothing like a robbery or a random tragedy—and the prominence of his official crime-fighting record and unofficial advocacy role led to widespread assumption that his death was a retaliatory “hit.” The Justice Department considers him the first and only U.S. prosecutor to have been killed in the line of duty.
A week after 17 people were murdered in a mass shooting at Marjory Stoneman Douglas High School in Parkland, Florida, teenagers across South Florida, in areas near Washington, D.C., and in other parts of the United States walked out of their classrooms to stage protests against the horror of school shootings and to advocate for gun law reforms.
A week after 17 people were murdered in a mass shooting at Marjory Stoneman Douglas High School in Parkland, Florida, teenagers across South Florida, in areas near Washington, D.C., and in other parts of the United States walked out of their classrooms to stage protests against the horror of school shootings and to advocate for gun law reforms. Student survivors of the attack at Marjory Stoneman Douglas High School traveled to their state Capitol to attend a rally, meet with legislators, and urge them to do anything they can to make their lives safer. These teenagers are speaking clearly for themselves on social media, speaking loudly to the media, and they are speaking straight to those in power—challenging lawmakers to end the bloodshed with their “#NeverAgain” movement.
Why the ingrained expectation that women should desire to become parents is unhealthy
In 2008, Nebraska decriminalized child abandonment. The move was part of a “safe haven” law designed to address increased rates of infanticide in the state. Like other safe-haven laws, parents in Nebraska who felt unprepared to care for their babies could drop them off in a designated location without fear of arrest and prosecution. But legislators made a major logistical error: They failed to implement an age limitation for dropped-off children.
Within just weeks of the law passing, parents started dropping off their kids. But here's the rub: None of them were infants. A couple of months in, 36 children had been left in state hospitals and police stations. Twenty-two of the children were over 13 years old. A 51-year-old grandmother dropped off a 12-year-old boy. One father dropped off his entire family—nine children from ages one to 17. Others drove from neighboring states to drop off their children once they heard that they could abandon them without repercussion.
Here are some readers with extra elements on this discussion—political, cultural, international. First, an American reader on the interaction of current concepts of masculinity and the nearly all-male population of mass gun murderers:
The path to its revival lies in self-sacrifice, and in placing collective interests ahead of the narrowly personal.
The death of liberalism constitutes the publishing world’s biggest mass funeral since the death of God half a century ago. Some authors, like conservative philosopher Patrick Deneen, of Why Liberalism Failed, have come to bury yesterday’s dogma. Others, like Edward Luce (The Retreat of Western Liberalism), Mark Lilla (The Once and Future Liberal), and Steven Levitsky and Daniel Ziblatt (How Democracies Die) come rather to praise. I’m in the latter group; the title-in-my-head of the book I’m now writing is What Was Liberalism.
But perhaps, like God, liberalism has been buried prematurely. Maybe the question that we should be asking is not what killed liberalism, but rather, what can we learn from liberalism’s long story of persistence—and how can we apply those insights in order to help liberalism write a new story for our own time.
A new study explores a strange paradox: In countries that empower women, they are less likely to choose math and science professions.
Though their numbers are growing, only 27 percent of all students taking the AP Computer Science exam in the United States are female. The gender gap only grows worse from there: Just 18 percent of American computer-science college degrees go to women. This is in the United States, where many college men proudly describe themselves as “male feminists” and girls are taught they can be anything they want to be.
Meanwhile, in Algeria, 41 percent of college graduates in the fields of science, technology, engineering, and math—or “STEM,” as it’s known—are female. There, employment discrimination against women is rife and women are often pressured to make amends with their abusive husbands.
According to a report I covered a few years ago, Jordan, Qatar, and the United Arab Emirates were the only three countries in which boys are significantly less likely to feel comfortable working on math problems than girls are. In all of the other nations surveyed, girls were more likely to say they feel “helpless while performing a math problem.”
The president’s son is selling luxury condos and making a foreign-policy speech.
Who does Donald Trump Jr. speak for?
Does the president’s son speak for the Trump Organization as he promotes luxury apartments in India? Does he speak for himself when he dines with investors in the projects? Does he speak for the Trump administration as he makes a foreign-policy speech in Mumbai on Friday?
“When these sons go around all over the world talking about, one, Trump business deals and, two, … apparently giving speeches on some United States government foreign policy, they are strongly suggesting a linkage between the two,” Richard Painter, President George W. Bush’s chief ethics lawyer who is a professor of law at the University of Minnesota, told me. “Somebody, somewhere is going to cross the line into suggesting a quid pro quo.”If permissions to modify an Organizational Unit (OU) are intentionally or accidentally delegated to a user who shouldn’t have them, it can lead to leakage of sensitive data. For example, a user with these |
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] | -0068642-g003){ref-type="fig"}. Bacteria retrieved from those plants were predominantly represented by members of the Leuconostocaceae, Bacillaceae, and Streptococcaceae families ([Figure 3B)](#pone-0068642-g003){ref-type="fig"} and specifically classified as species of *Leuconostoc* *,* *Lactococcus* *, Bacillus*, and *Exiguobacterium* ([Figure 5)](#pone-0068642-g005){ref-type="fig"}.
{#pone-0068642-g005}
Temporal and irrigation effects on the phyllosphere microbiota {#s3.5}
--------------------------------------------------------------
Within individual field trials, the bacterial composition on lettuce was typically distinct at each time point ([Table 1)](#tab1){ref-type="table"}. These differences were at least partially explained by the increased Phylogenetic Diversity (alpha-diversity) on leaves from plants collected at 21 dpi compared to plants at either 7 or 14 dpi ([Figure 6)](#pone-0068642-g006){ref-type="fig"}. The Chao1 species richness metric also positively correlated with the PD estimator (r^2^=0.89, data not shown). Similarly, temporal changes in the bacterial diversity were identified according to PCoA on Unifrac distances. For example, a temporal change in bacterial composition on lettuce was evident between 7 dpi and 21 dpi in L10 ([Figure 7A)](#pone-0068642-g007){ref-type="fig"}. At 14 dpi, the microbiota were typically similar to plants collected at either 7 dpi or 21 dpi, possibly indicating a transition from lower to higher bacterial diversity ([Figure 7A)](#pone-0068642-g007){ref-type="fig"}.
###### Cluster quality using weighted UniFrac community analysis.
**E09** **L09** **E10** **L10**
---------------------------- --------- --------- --------- ---------
Day (dpi) 1.129\* 1.298\* 1.138 1.113\*
Irrigation method 1.018 1.057 1.114 1.006
*E. coli* O157 inoculation 1.002 1.004 1.172\* 1.031
*E. coli* O157 persistence 0.992 0.967 1.045 1.026
Cluster quality was calculated based on the dissimilarity ratio between/within clusters of samples in a treatment group where a high ratio signifies a distinct cluster. The distance matrices from the weighted UniFrac analysis were used to compute the dissimilarity ratio.
\* The highest cluster quality ratio observed in a given planting.
{#pone-0068642-g006}
{ref-type="supplementary-material"}.](pone.0068642.g007){#pone-0068642-g007}
To identify irrigation-dependent effects on the microbiota, it was necessary to compare plants collected on the same day. UniFrac distances examined using ANOSIM revealed that the microbiota on sprinkler- and drip-irrigated plants were significantly different from each other for eight out of the 12 time points sampled ([Table 2)](#tab2){ref-type="table"}. The irrigation effects found for one day are shown in [Figure 7B](#pone-0068642-g007){ref-type="fig"}. Although no single genus consistently distinguished the bacterial communities between drip and sprinkler irrigated plants, *Xanthomonas* was typically more abundant on sprinkler-irrigated plants and *Erwinia* was enriched on drip-irrigated plants (data not shown). The relative abundance of *Leuconostoc* and *Lactococcus* was also higher on drip-irrigated plants, but only for E09 and E10 plantings.
###### ANOSIM cluster analysis of the phyllosphere microbiota between sprinkler- and drip-irrigated Romaine lettuce plants.
**E09** **L09** **E10** **L10**
-------------------- --------- --------- ------------------------------ ------------------------------ --- -------------------------------- ---------------------------------- -------------------------------- ------- ---------------------------------- -------------------------------- --------------------------------
Unweighted UniFrac -0.02 -0.006 0.1 **0.13** [**\***](#ngtab2.1) 0 **0.55** [**\*\***](#ngtab2.2) 0.22 **0.44** [**\*\***](#ngtab2.2) 0.013 **0.36** [**\*\*\***](#ngtab2.3) **0.33** [**\*\***](#ngtab2.2) **0.42** [**\*\***](#ngtab2.2)
Weighted UniFrac -0.16 -0.068 **0.22** [**\***](#ngtab2.1) **0.13** [**\***](#ngtab2.1) 0 0.12 **0.67** [**\*\*\***](#ngtab2.3) **0.44** [**\*\***](#ngtab2.2) 0.063 -0.029 0.0026 -0.13
The R-statistic is shown for each comparison of clusters of differentially irrigated plants.
\* 0.05 \< *P* ≤ 0.1;
\*\* 0.01 \< *P* ≤ 0.05;
\*\*\**P* ≤ 0.01
The phyllosphere microbiota differed on plants inoculated with *Escherichia coli* O157:H7 {#s3.6}
-----------------------------------------------------------------------------------------
Inoculation of *E. coli* O157:H7 altered the phyllosphere to the extent that the lettuce microbiota differed between inoculated and control plants for 10 of the 12 time points examined ([Figure S7](#pone.0068642.s007){ref-type="supplementary-material"}). The result for one of the time points, 14 dpi in L10, is shown in [Figure 7C](#pone-0068642-g007){ref-type="fig"}. Notably, the phyllosphere microbiota recovered from naive (not sprayed) and buffer-only inoculated plants were indistinguishable and differences associated with other factors were more important determinants of the bacterial diversity ([Figure 7C and S8)](#pone-0068642-g007){ref-type="fig"}. Therefore the differences in bacterial inhabitants were most likely due to *E. coli* O157:H7 and not the 0.1% peptone buffer used to deliver the pathogen onto the lettuce.
The bacterial community composition was also distinct between InocPOS and InocNEG plants for nine of the 12 time points sampled, including 14 dpi in L10 ([Figure 7D)](#pone-0068642-g007){ref-type="fig"}. These differences were partially associated with the enrichment of certain bacteria. For example, at 14 dpi in L10, *Erwinia* was significantly enriched in the phyllosphere of InocNEG plants (*P* ≤ 0.05) according to the Kruskal-Wallis multiple comparison test. *Erwinia* was also enriched on InocNEG plants 2.7-fold and 9.2-fold at 14 and 21 dpi in the L09 trial. However, the |
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] | type="ref"} Interestingly, our current study demonstrates the induction of protein synthesis after ECC coincides with reduced AMPK activation in tumour‐bearing mice. Furthermore, reduced AMPK activation after a single ECC bout has also recently been observed in castrated mice.[51](#jcsm12271-bib-0051){ref-type="ref"} These findings are in contrast to our previous observations using low‐frequency electrical stimulation and point to the differential regulation of muscle metabolic signalling by different types of contraction. We previously found a sustained AMPK activation following a single bout of low‐frequency concentric contractions in cachectic skeletal muscle.[32](#jcsm12271-bib-0032){ref-type="ref"} The specificity of the responses induced by different types of contractions may be related to metabolic stress as cachectic muscle develops mitochondrial dysfunction.[52](#jcsm12271-bib-0052){ref-type="ref"}, [53](#jcsm12271-bib-0053){ref-type="ref"}, [54](#jcsm12271-bib-0054){ref-type="ref"} The cachectic muscle\'s anabolic and metabolic response to different contraction types will require further investigation. Nonetheless, our findings suggest that ECC may be a potential therapeutic treatment to promote muscle anabolism during cancer cachexia progression.
Muscle signalling related to inflammation, energy status, and proteostasis are disrupted during cachexia progression and have been implicated in the regulation of muscle wasting.[55](#jcsm12271-bib-0055){ref-type="ref"}, [56](#jcsm12271-bib-0056){ref-type="ref"} Interestingly, many of these same pathways are induced by muscle contraction and exercise.[57](#jcsm12271-bib-0057){ref-type="ref"} IL‐6 and muscle STAT3 signalling through the gp130 receptor are activated during the progression of cachexia[30](#jcsm12271-bib-0030){ref-type="ref"}, [52](#jcsm12271-bib-0052){ref-type="ref"}, [58](#jcsm12271-bib-0058){ref-type="ref"} and are associated with mTORC1 and protein suppression in pre‐clinical cachexia models.[7](#jcsm12271-bib-0007){ref-type="ref"}, [28](#jcsm12271-bib-0028){ref-type="ref"} Inhibition of muscle IL‐6 signalling through either direct STAT3 inhibition or gp130 loss can attenuate wasting in mouse models of cachexia.[30](#jcsm12271-bib-0030){ref-type="ref"}, [31](#jcsm12271-bib-0031){ref-type="ref"} We have previously found that short‐term PDTC treatment attenuated the suppression of mTORC1 signalling and protein synthesis while concomitantly reducing muscle STAT3 and NFκB activation in *Apc* ^*Min/+*^ mice.[29](#jcsm12271-bib-0029){ref-type="ref"}, [32](#jcsm12271-bib-0032){ref-type="ref"} We extend these findings by demonstrating a single PDTC dose improved basal protein synthesis. It has recently been suggested that intermittent cycles of pathway inhibition/activation may be required to combat muscle wasting during cancer cachexia.[59](#jcsm12271-bib-0059){ref-type="ref"} Indeed, many cytokine‐related signalling pathways have established roles in myogenesis[60](#jcsm12271-bib-0060){ref-type="ref"} and load‐induced muscle growth and remodelling.[41](#jcsm12271-bib-0041){ref-type="ref"}, [42](#jcsm12271-bib-0042){ref-type="ref"}, [61](#jcsm12271-bib-0061){ref-type="ref"} Therefore, we utilized an experimental paradigm that lowered chronic muscle inflammatory signalling but did not block contraction‐induced signalling.[32](#jcsm12271-bib-0032){ref-type="ref"} Importantly, we found that PDTC treatment increased both basal and ECC‐induced protein synthesis in cachectic muscle. These findings demonstrate that cachectic muscle retains the anabolic capacity to increase protein synthesis, and inflammatory signalling contributes to the suppression of these processes. Additional research is warranted to determine the specific mechanisms related to STAT3 and NFκB that serve to diminish the capacity for protein synthesis in cachectic muscle. Moreover, further research is also required to determine the effect of muscle inflammatory signalling on metabolic remodelling in response to repeated contraction bouts, which could dramatically impact health outcomes related to exercise.
Conclusions {#jcsm12271-sec-0023}
-----------
In summary, we examined cachectic muscle\'s ability to induce protein synthesis in response to ECC and determined the role of muscle inflammatory signalling involving STAT3 and NFκB on ECC‐induced anabolic signalling. We found that mechano‐sensitive signalling pathways related to P38, ERK1/2, and Akt were not altered by the cachectic environment in wasting muscle. While cachexia did not attenuate the ECC induction of mTORC1 signalling, the capacity for protein synthesis remained suppressed compared with healthy controls. Interestingly, we found that reducing muscle STAT3/NFκB signalling improved basal and ECC‐induced protein synthesis during severe cachexia. These studies demonstrate that mechano‐sensitive signalling pathways are maintained in skeletal muscle, but STAT3/NFκB signalling serves to attenuate basal and ECC‐induced protein synthesis. Further work is necessary to determine whether intermittent anti‐inflammatory therapies combined with exercise training may be useful to alleviate suppressed muscle protein synthesis during cancer cachexia.
Conflict of interest {#jcsm12271-sec-0026}
====================
Justin P. Hardee, Brittany R. Counts, Song Gao, Brandon N. VanderVeen, Dennis K. Fix, Ho‐Jin Koh,, and James A. Carson declare that they have no conflict of interest.
The authors thank Gaye Christmus and Dr Bradley Gordon for editorial review of the manuscript.
This work was supported by National Institutes of Health \[grants R01 CA‐121249 (National Cancer Institute) and P20 RR‐017698 (National Institute of General Medical Science)\] to J.A.C, SPARC Graduate Research Grant from the Office of the Vice President for Research at the University of South Carolina to J.P.H and an ACSM Foundation Research Grant from the American College of Sports Medicine Foundation to J.P.H. The authors certify that they comply with the ethical guidelines for authorship and publishing of the Journal of Cachexia, Sarcopenia and Muscle.[62](#jcsm12271-bib-0062){ref-type="ref"}
Q:
Split duplicates in lists using LINQ
So far I have this code
public class Card
{
public int suitID;
public int cardValue;
}
public class DeckManager
{
private List<List<Card>> FindCardsPerSuit(List<Card> cards)
{
var _cardsCombination = cards
.GroupBy(x => x.cardValue)
.Where(g => g.Count() > 2)
.Select(c => c.ToList())
.ToList();
return _cardsCombination;
}
}
I'm working on a Rummy card game and what I'm trying to do is to find if the combination of cards that the player want to play is valid or not.
When the player selects some cards from the hand, I need to check if the cards with the same value have a unique suit, otherwise, add it to a new list.
Example:
The player has 8 cards all with the same value but different suits, the min combination is 4 so you can do 2 combinations, and because you play with 2 decks you have 2 cards per suit.
How can I find out if I want to create a list of lists of combinations?
At the moment the _cardsCombination query gets all the cards selected and make a smaller group with all the cards with the same value. How can I do the same thing and create subgroups for each card with suit duplicate?
Thank you.
A:
var _cardsCombination = cards
.GroupBy(x => x.cardValue)
.SelectMany(g => {
// group cards by suit
var cardsPerSuit = g.GroupBy(c => c.suitId);
// max number of cards with same suit (will be 1 or 2 for two decks)
// this will be number of subsets
var maxCardsPerSuit = cardsPerSuit.Max(gg => gg.Count());
return Enumerable
// create subset for each setNumber from 0 to maxCardsPerSuit - 1
.Range(0, maxCardsPerSuit)
.Select(setNumber => cardsPerSuit
// take nth card from each suit
.Select(s => s.ElementAtOrDefault(setNumber))
// skip nulls
.Where(s => s != null)
);
})
.Where(g => g.Count() > 2)
.Select(c => c.ToList())
.ToList();
McConnell Aid: “She’s clearly, this sounds extreme, but she is emotionally unbalanced. I mean it’s been documented. . . she’s suffered some suicidal tendencies. She was hospitalized for 42 days when she had a mental breakdown in the ’90s.” There are also allegations that Jud |
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] | answer special about the virus, spending most of his time talking about the way America could use the crisis to enact their leftist energy policies.
Biden recalled the Great Depression, noting former President Franklin Roosevelt used that crisis to enact dramatic government programs, something he also wanted to do.
“It’s like the New Deal,” he said. “Think of every great act that — every great change that has taken place. It’s come out of a crisis.”
Biden proposed a similar dramatic surge in government spending for green energy infrastructure, including 550,000 charging stations for electric cars, windmills and solar panels, as well as spending for better battery technology.
Biden said the coronavirus crisis would lead the American people to recognize the need for change, especially for workers and Americans suffering the effects of “systemic racism.”
“It’s like the Band-Aid has been ripped off,” Biden said.
The former vice president’s hat-tip to the Green New Deal comes as prominent leftist Rep. Alexandria Ocasio-Cortez has criticized his climate change platform.
“I don’t think that the vice president has a climate change policy that is sufficient right now,” Ocasio-Cortez said in a recent interview.What others say:
I just want to thank you again for
representing me. You have provided so much for the kids and me that I could not
properly put into words. I can say that I have a new measure of freedom,
safety, boundaries, strength and peace that prior to meeting you I did not
have. Thank you for standing firm
for me when no one else would and when I
didn't know how to.
-- J.U.,
Marysville,WA
In a time that was very difficult and
painful, Paul worked on my behalf and for my children. He took charge, fought
for us and steered us through.
He did this in a way that caused us to feel safe
in the midst of turmoil.
I will be forever thankful for his expertise and his
kindness. -- C.B., Bellevue, WA
I have worked with other attorneys
before and I have to say that my experience with Mr. Petry was the best. He
really took good care of my case, made me aware of my options, and went above
and beyond to help not only provide counsel, care and concern for me, but
worked his best to achieve the best outcome between the different parties'
grievances. Without any reservations, I recommend Paul Petry to anyone seeking
legal counsel and advice.-- A.A.,
Seattle, WA
Paul Petry was very professional,
encouraging and supportive during my painful divorce, while also highly skilled
at reaching a fair settlement in a short amount of time, though never rushing
my divorce to finality. He kept my legal costs to a minimum and did not try to
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Throughout the process, Paul consistently advised me of options to consider in
order to protect my emotional, financial and legal well-being.-- I.H., Issaquah, WAQ:
ASP.NET Core 2.1 - Stack overflow exception related to dependency injection
I'm getting a stack overflow exception after I load 4 or 5 times a simple controller action. The web app is running on Azure and I was able to dump the exception information and the problem seems to be related to Dependency Injection.
internal object GetService(Type serviceType, ServiceProviderEngineScope serviceProviderEngineScope)
{
if (_disposed)
{
ThrowHelper.ThrowObjectDisposedException(); --> this is executed
}
var realizedService = RealizedServices.GetOrAdd(serviceType, _createServiceAccessor);
_callback?.OnResolve(serviceType, serviceProviderEngineScope);
return realizedService.Invoke(serviceProviderEngineScope);
}
Running the web app in my computer has no issues, it only fails in PROD.
This is how I captured the exception in Azure: https://blogs.msdn.microsoft.com/benjaminperkins/2017/06/28/capture-a-stackoverflowexception-and-make-a-dump-0xc00000fd/
I opened the dump in Visual Studio and I could identify the code line where it failed (described above) but I still don't know how to fix it. All my dependencies are resolved with 'scope' lifetime.
Any help is appreciated.
A:
I finally fixed it! I had a class that had like 20 dependencies and each dependency had more dependencies, maybe 4 or 5 level. There were no circular dependencies because this was working fine in my development environment. After I did a refactoring and reduced the dependencies, it worked out fine.
Because it was working fine in my development environment but not in Azure App Service, I assume there's some limitation on the dependency instances or levels you can define when the app is hosted in Azure.
This was my methodology to fix it:
1) Find the simplest case that fails.
2) Comment out all the depedencies and try again. It worked, ok, it's about dependencies.
3) Dump the stack overflow exception in production as this error didn't occur in the dev environment.
4) Confirm it's a dependency injection issue and examine .NET Core source code.
5) Reduce dependency instances and levels.
6) Deploy. If it doesn't work, go to (5). If it works, you are happy again :)
Our Top 5 Instagram Tips for 2019
Instagram is quickly becoming a go-to platform for businesses across the United States and Scottsdale-based the spr agency, an award-winning social media and public relations agency, has released its top 5 tips for succeeding on the platform in 2019.
Be Authentic
The rush to capitalize on the popularity of any social media platform may also bring snap decisions on just what a company should post. Many companies chase trends instead of setting them.
“While it’s easy to duplicate what others in your industry or vertical are doing, it’s more important to be authentic and true to your brand,” said Al Stevens, president and founder of the spr agency. “Social media users know when you’re phoning it in. They know when you’re not being yourself. And with all marketing, it’s important to speak authentically and provide a unique perspective.”
Be Creative
While authenticity is a must, it’s also important to be creative in your approach.
“Given the number of Instagram posts that hit the platform’s news feed each day, Instagram users want to see originality and the spark of creativity,” said Christy Stevens, vice president of the spr agency. “They’re looking for posts that will inspire and entertain them. That’s what they choose to engage with when they double-tap a photo.”
Great Photography Makes Great Content
Investing in quality images is a must on any social media platform but it’s key to engaging Instagram users. There is a direct correlation between great photography and high engagement on Instagram.
“Think of what inspires you and what will inspire your customers,” Al Stevens said. “If you’re not excited by the image you choose, how will your customers and followers be? You have to believe in each image and be willing to defend your job with the photo selection you make. It’s that important.”
Hashtags Matter
Thinking about throwing a few hashtags on that Instagram post? Don’t – at least not without researching the hashtags that best fit your post and your brand.
“Hashtags for the sake of hashtags is definitely not a successful strategy,” Christy Stevens said. “It’s important to select hashtags that will help your post build a successful base and launch it into a higher sphere of influence.”
Don’t Forget the Video
While still images are the primary way of succeeding on Instagram, it’s important to branch out into the company’s other posting avenues – Instagram Stories and IGTV. Both video products have gained traction over the past 18 months and are expected to continue to gain market share against Instagram’s original still imagery news feed.
Instagram Stories quickly outpaced Snapchat upon their launch and the allure of IGTV for videographers stems from its freeform use of video – with no time limits set by Instagram.
For more information about the spr agency, please visit www.thespragency.com or call (480) 648-1770.Pages
Tuesday, May 15, 2012
Biggest bust/improvement: Donruss
Hey! It's Harold Reynolds again!
This is not a repeat. This is post number 2,001. I republished this card both as a reminder to enter the contest and as a lead-in to my next judging fiesta, namely, figuring out the biggest improvement and bust in the history of Donruss.
I don't think Donruss has as avid a following as the previous two brands we've compared, Topps and Upper Deck. I know I'm not crazy about many of the sets that Donruss produced over the years.
My personal Donruss favorites are 1984 and 1985. Plus, 1981 |
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] | fare for accelerating technoculture & screaming memes, with a side order of strangeness and charm. Read articles and interviews which illuminate the New Edge culture.
Warning:This site may contain unlabelled irreverence and subtle playfulness.Humorless and hypersensitive people should proceed with caution.TOMORROW'S TECHNOLOGY TODAY: Cell phones
For the most part your cell phones do all the work...making calls, sending text messages, taking pictures. In Tomorrow's Technology Today Matt Stone shows us that the phone case is now being used to do some pretty cool stuff too.These are sound effects I have recorded for different projects that I am giving away. Check back as I add to the page often. Click on the description to download. I cannot predict your browser configuation so this will either make a page with a player or ask you where to save it. If it makes a player, right-click and choose "Save As... instead"A procession of 60 cars honking their horns and brandishing signs proclaiming “Free Them All” circled Bergen County Jail in Hackensack, New Jersey on March 27. A prisoner and guard in the jail had just tested positive for COVID-19, and the protesters were demanding that all nonviolent incarcerated people and ICE detainees be released in order to stop the spread of the virus and save thousands of lives.
The protesters called it a “drive-by protest.” Since late March, similar actions involving hundreds of cars have taken place in other states as well, including Louisiana, Illinois and North Carolina. The protests are just one of the many creative tactics that organizers have been employing to show solidarity with the immigrant community while social distancing.
Ambien Mitchell is an activist and educator working at New Sanctuary Coalition, a clinic that provides legal and emotional support for people navigating the immigration system. In her view, it has never been more critical to advocate for humane policy and demand accountability for those in power.
“We’re living in a system of state violence, with decades of experience perpetuating incredible cruelty on vulnerable populations,” Mitchell said. “The state has already proven to have a blatant disregard for human life. And they’ve already proven that they believe some lives are less valuable than others.”
“Every prison and every detention center is like a cruise ship that’s not allowed to dock.”
Although the entire nation is grappling with the COVID-19 pandemic and its consquences, the undocumented community has been facing unique — and often overlooked — struggles. Those imprisoned in detention centers are kept in close quarters where social distancing is impossible. Economic relief plans such as the CARES Act neglect undocumented people altogether, though many undocumented workers are providing essential labor during this crisis and most undocumented people pay taxes. Meanwhile, despite the federal government’s own admission that the best thing that can be done to flatten the curve is to limit travel, deportations and ICE raids are still taking place.
“It’s no secret that the undocumented community has been targeted and criminalized for decades,” said undocumented organizer Li Adorno, who works with the New Jersey chapter of the immigrant rights group Movimiento Cosecha. “Even in a crisis, the undocumented community is still being targeted. We’re always the ones that the government forgets about.”
‘Free them all’
Kathy O’Leary is the region coordinator for New Jersey at Pax Christi USA, a national Catholic peace and justice organization. In the past, she has helped compile reports on the desperate conditions plaguing New Jersey jails. Since the quarantine began, O’Leary has been pouring her energy into the fight for ICE detainees and prisoners to be released. In addition to organizing drive-by protests of detention centers in New Jersey, she’s also helped draft a petition calling on Gov. Phil Murphy to use his emergency powers to take action.
“On a good day, getting access to health care when you’re in prison is completely at the mercy of the administration,” O’Leary said. “And a jail is not a sealed environment. Even though they cut off visitation, the guards still rotate three times a day and then go home to their families. The guards could very easily bring the virus back to the jail without knowing it — and if there is an outbreak in the jail, then that gets brought back to the community.”
The petition is backed by over 30 social justice and immigrant rights organizations with chapters in New Jersey, including the Jewish Coalition for Refugees, the Sunrise Movement and Cosecha.
“Even if all the petition does is elevate the issue — that’s important too,” O’Leary said. She considers the petition an opportunity to stand with incarcerated people across New Jersey who are going on hunger strike, demanding access to essentials like gloves, masks, soap and hand sanitizer. Skipping even a single meal in the dining hall of a detention center comes with the risk of being thrown in solitary confinement.
Holding ICE accountable for their failures
According to Ambien Mitchell of New Sanctuary Coalition, phone calls are another simple and remote option when it comes to advocating for undocumented people during the crisis. She suggests calling elected representatives because they can pressure ICE, as well as calling ICE field agents and detention centers themselves.
“Every prison and every detention center is like a cruise ship that’s not allowed to dock,” Mitchell said. “And at this point, inaction has become an incredibly brutal and violent action. These aren’t fun conversations, but they’re conversations that are worth having — ICE is a federal agency, and we do pay their salaries with our tax dollars.”
Adorno believes that ICE’s unwillingness to cease operations is not only putting detainees at risk, but the community at large. “Even during the pandemic, ICE continues to hunt down undocumented community members,” Adorno said. “In the past, ICE has claimed they would not go to school zones and courts — but then went against their own memos. That’s why the immigrant and undocumented community has very little faith in the local or federal government.”
The impact of this mistrust is that even if they are experiencing symptoms, many undocumented people may hesitate to go to a hospital, despite ICE’s claim that they will not be arresting people who are seeking medical care.
“Undocumented people don’t have health insurance, and they’re afraid to seek care at hospitals because ICE might go there,” Adorno said. “If you only have one member of the family who is working right now, and they get arrested, how is that going to impact the rest of their family?”
Campaigns for commissary and worker relief
First Friends is an organization of people who visit detained immigrants and asylum seekers in New York and New Jersey. Because of the crisis, their volunteers can no longer visit detention centers — so the organization has started a Gofundme to raise commissary money. Often, detainees can’t afford to buy the basics due to marked up prices and meager salaries that border on slave wages.
“Commissary can be used to help incarcerated people feel a little more comfortable during this stressful time,” O’Leary said. “Buying an extra pack of ramen noodles or a candy bar can make them feel more human. But there are other things in there too — like soap and shampoo.”
She noted that while inmates in places like New York are being used to produce thousands of gallons of hand sanitizer for less than a dollar an hour, they are not allowed to purchase sanitizer themselves because of the alcohol content. O’Leary also added that in addition to buying hygiene products, the crowdfunded commissary can also be used for phone calls to family, lawyers and friends — crucial connections to the outside world in a time when many inmates are lonelier and more isolated than ever.
Also organizing to respond to financial need is Cosecha, a coalition of undocumented people and allies who have previously won fights like driver’s licenses for all in New Jersey. “Undocumented communities have always joined together to surpass tough times like this,” Adorno said, who is currently quarantined with Cosecha members and developing strategies for relief. “In our home countries, we don’t have a lot of help. The mutual aid we’re seeing rise up — this is the kind of thing that the undocumented community thrives at. We’re good at this because we’ve had to do it in the past. Nobody else is going to come rescue us.”
Since the pandemic began, immigrants rights groups like Cosecha have been mobilizing to create relief funds for the undocumented community. (WNV/Loretta Graceffo)
Because of their legal status, undocumented workers don’t have access to necessities like health insurance, paid sick leave, unemployment and other forms of government relief. In order to help ease the burden, Cosecha has started a fund to help families with needs like food, rent and utilities during the crisis.
“You can’t feed a movement with service,” Adorno said. “You have to feed a movement by bringing people together. This fund has to be accompanied by organizing efforts. Otherwise it’s going to be really hard to sustain it.”
Since the pandemic, Cosecha has begun training organizers through video conferences — and shifted its focus towards pushing for economic measures that will elevate undocumented and working class people, like popularizing the idea of a rent strike.
The future of the immigrant rights movement
COVID-19 is a health crisis of epic proportions, and its effects on the undocumented community have been devastating in ways that most Americans will never experience. At the same time, the pandemic has produced opportunities to mobilize and opened the door to conversations about |
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] | app1-cancers-10-00031){ref-type="app"}.
3.13. Statistical Analysis {#sec3dot13-cancers-10-00031}
--------------------------
Statistical differences between controls and drug-treated cells were determined by one-way ANOVA (Sidak). *p*-values \< 0.05 were considered statistically significant. Data were analyzed using the Stata 8.2/SE package (StataCorp LP, College Station, TX, USA).
4. Conclusions {#sec4-cancers-10-00031}
==============
It is well established that drug tolerance is one of the key challenges for dual PI3K--mTOR inhibitors as NVP-BEZ235, which explains the slow progress of research and development of these inhibitors. Currently, only eleven new dual PI3K--mTOR inhibitors, including NVP-BEZ235, are being evaluated actively in the clinical stage, is currently in phase I/II clinical trials for advanced solid tumors (ClinicaTrials.gov, U.S. National Institutes of Health, Bethesda, MD, USA: <http://clinicaltrials.gov>), but none has been approved by the FDA. Although significant therapeutic effects against cancer have been demonstrated, NVP-BEZ235 have shown significant toxicity, including stomatitis, noninfectious pneumonitis, rash, hyperglycemia, and immunosuppression. Encapsulation strategy offers a potential approach for enhancing the solubility of NVP-BEZ235 improving its bioavailability and suggests the potential use of this formulation for oral administration. Oral administration would allow outpatient treatment, improving quality of life and reducing treatment costs.
Cytosolic delivery strategies could contribute to simplify the entry or export of various cargo that are insufficiently permeable to plasma membrane. In this work we proposed an engineered system, based on CaCO~3~, to deliver NVP-BEZ235. Because of their central role in the initiation and progression of tumors, blockade of the mTOR and PI3K signaling pathways has emerged as a compelling target for the development of novel drug formulations for maximal therapeutic efficacy in many tumors. Taken together, it appears that dual PI3K/mTOR inhibitors, such as NVP-BEZ235, are required. Because of its intrinsic chemical hydrophobicity, NVP-BEZ235 is poorly tolerable from patients and negatively influenced the clinical studies \[[@B27-cancers-10-00031]\]. Its toxicity profile causes high percentage of adverse events leading to frequent discontinuation treatments. Despite these problems NVP-BEZ235 remains an attractive agent. Therefore, in order to overcome its chemical limitations, it is necessary to either reduce the administered dose or combining the efficacy of this molecule with other drugs for a synergic action. In view of its potentiality, and on the other side of its limitations, we focused this work on finding a nanotechnological strategy to achieve higher efficacy of the drug toward cancer cells, decreasing drug concentration and increasing drug penetration. Hence, we developed at first a promising payload drug delivery system based on CaCO~3~ NCs that improved the water solubility of NVP-BEZ235 making it immediately available to cell machinery. Furthermore, a new highly sensitive analytical method methods have been used to determine, qualitatively or quantitatively, whether NVP-BEZ235 has successfully traversed the cell membrane. The obtained nano-formulation has a cytosolic localization more efficient (almost 30%) than the free drug as demonstrated in the quantification analysis of NVP-BEZ235 in the intracellular fraction. This result is affected in a cytotoxic effect almost 50 times higher than free drug at the same nominal concentration, in T-cell lymphoma line, as well as in the phosphorylation of proteins involved in the mTOR pathway, as demonstrated in the western blot analysis. These overall results show that the fabrication of loaded NVP-BEZ235 CaCO~3~ nanocrystals is a promising drug delivery system able to improve the pharmacokinetics of this drug.
Progetto "Tecnologie Abilitanti per Produzioni Agroalimentari Sicure e Sostenibili" (T.A.P.A.S.S)---"Cluster Tecnologici Regionali 2014". Codice regionale progetto PELM994 (CUP B38C14002040008). "FuturelnResearch" APQ Ricerca Regione Puglia---Programma regionale a sostegno della specializzazione intelligente e della sostenibilità sociale ed ambientale. PRIN 2010--2011 (D.M. 1152/ric del 27/12/2011) Nanotecnologie molecolari per il rilascio controllato di farmaci/NANO Molecular tEchnologies for Drug delivery NANOMED prot. 2010FPTBSH, CUP: F81J12000380001 is gratefully acknowledged.
Viviana Vergaro and Giuseppe Ciccarella conceived and designed the experiments; Monica Civallero and Maria Cosenza performed the biological experiments; Francesca Baldassarre analyzed all data experiments with statistical analysis; Cinzia Citti and Giuseppe Cannazza performed LC-MS/MS experiments and contributed to results and discussions; Francesco Paolo Fanizzi, Stefano Sacchi and Samantha Pozzi provided the reagents and materials and contributed to results and discussions. Viviana Vergaro and Monica Civallero wrote the paper.
The authors declare no conflicts of interest.
• Detection and quantification limits (sensitivity)
Limit of quantification (LOQ) was defined as the concentration at which the quantifier transition of BEZ235 yielded a signal to noise ratio (S/N) of 10 and it was 1 μM in cell lysate. Limit of detection (LOD) in cell lysate was estimate based on 5:1 S/N and it was 0.5 μM.
• Specificity
Typical SRM chromatograms of BEZ235 and IS in cell lysate showed no interfering peaks from endogenous substances at the retention time of BEZ235 and IS. The chromatograms of blank cell lysate also had no interfering peaks at the retention times of BEZ235 and IS. The specificity results indicate that the method is highly selective for BEZ235 analysis.
• Calibration curve and Linearity
Calibration curves for BEZ235 were performed in cell lysates (1 to 100 μM). Five replicates were used to establish the linear calibration equation (y = mx + c) and analyzed using the ratio of analyte peak area over IS peak area after quantitative integration by Mass Hunter software. Linearity was measured as the coefficient of determination (R2) for five calibration replicates. The acceptance criteria for each back-calculated standard concentration were ±15% deviation from the nominal value except at LOQ, which was set at ±20%. Linearity was excellent in the range 1--100 μM with corresponding coefficient of determination R2 \> 0.998.
• Accuracy and precision
Intra-day accuracy and precision were assessed from five replicates of LOQ and QC concentration levels (low LQC, middle MQC and high HQC). Inter-day accuracy and precision were assessed on three triplicates for five-day analysis of the three QC concentration levels. Accuracy of the method was calculated as percent deviation based on the difference between the mean concentration found and the nominal concentration. The percent deviation should be within 15% of the actual value, except at the LOQ, where it should not deviate by more than 20%. Precision was evaluated as percentage coefficient of variation (%CV) of the mean concentration found. The precision determined at each concentration level should not exceed 15% of the CV, except for the LOQ, where it should not exceed 20% of the CV.
The accuracy and precision data for cell lysate. The intra-day accuracy showed percent deviation ranging from −1.19 to 4.22% with a %CV from 0.88 to 4.65%. The inter-day accuracy and precision showed percent of deviation ranged from to −3.80 to 8.50% with a %CV from 2.09 to 8.78. Since the accuracy and precision values were found within the acceptance limits, these results suggested that the method is accurate and precise.
• Recovery
The extraction recovery of BEZ235 was determined at the LQC, MQC and HQC levels by comparing the peak areas of BEZ235 extracted from spiked cell lysate samples prepared by spiking BEZ235 in blank cell lysate with the corresponding concentration of authentic standard solutions. Experiments were performed in five replicates. The extent of recovery should be consistent, precise and reproducible. The recovery of extraction of BEZ235 from cell lysate was \>82%.
• Matrix effect
The matrix effect was evaluated by determining the matrix factor (MF) and the IS-normalized MF from cell lysate. The determination was performed at the LQC, MQC and HQC levels in triplicate. The MF of BEZ235 was calculated by comparing the peak area of BEZ235 extracted from samples prepared by spiking BEZ235 in cell lysate with the corresponding concentration of the authentic solution of BEZ235 prepared in mobile phase. The MF of IS was determined and calculated in a similar manner. The IS-normalized MF is the ratio between the MF of BEZ235 and that of IS. The %CV of the IS-normalized MF from blank cell lysate should not exceed 15%. The %CV of IS-normalized MF in cell lysate was \<10%. The %CV \< 15% suggests that ion suppression or enhancement from cell lysate matrix is negligible in the assay.
• Stability
Stock solutions of BEZ235 and IS were checked for short-term stability |
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Here he glanced at Neth'Gore quickly before continuing.
"As I said, a few of these human people had advanced capability, they were natural channels. I am sure had they been T'Iea then they would have been quickly taken up and sent to Ter'Hadsnefel to learn how to temper and control their natural ability, taught the arts and ways of our T'Iea mages. To leave them untrained would have been dangerous, both to themselves and to others. Stories abound of such humans destroying great swathes of the land either by miss use of the arcane or by un-tempered ability. As a result many who exhibited these traits, if discovered, where cast out to live solitary lives far from others of their kind, for the humans had a deep mistrust of them. Some of these unfortunate people were even ritually burned if they were thought to have misused their traits and un-tempered skill. Anyway, many of us were assigned to stay amongst these humans and help where we could. But Te'Onolan'u'De'Hu'uinned increasingly demanded restraint. Some of us helped more than we should perhaps, for his orders were not to interfere. "
As before Orln turned and gazed at Neth'Gore's back for a few seconds. Thor waited for Neth'Gore to say something for it seemed that Orln was inviting him to do so, but the mage remained with his back turned to them, toying with his gear.
Orln carried on with his explanation. "On returning from one such trip we learnt that the goblins had invaded our encampment, probably looking for food or an opportunity to thieve anything that they thought useful, or so we were told by others in the legion. The goblins were easily held off and sent running, for they were not many, and their attack was disorganised and uncoordinated with no real strategy or pre-planning. But Te'Onolan'u'De'Hu'uinned seemed to bare a strange hatred towards them and he ordered his guards to pursue the goblins, hunt them down and kill them. He said this would act as a deterrent to others. We were appalled to hear such an order for that is not our way of course. My understanding was that we should lay low and explore, our orders were to watch for T'Iea'Neat'Thegoran activity not to take grim revenge upon a lesser race.
Over the next few months, Te'Onolan'u'De'Hu'uinned seemed to change, his attitude grew more grave. He became insular, guarded and thoughtful, quick to anger. He ordered small unprovoked skirmishes into the goblin lands to attack their encampments and destroy the goblin infrastructure, burning any encampments that were found, hunting them down and killing them even fowling water sources known to be used by them. Many in the legion could not understand this, many sought to dissuade the command chain of the legion. Those that felt this way became organised and approached Te'Onolan'u'De'Hu'uinned in an attempt to discover why he felt such hatred for the goblins, alas these soldiers we never saw again. We were told they had been killed in a skirmish. But this we did not believe for the goblins were disorganised and had primitive weapons and little skill in wielding what they had, they could not overcome the skill of our soldiers unless by pure luck they overcame an individual by sheer numbers. So the persecution of the Goblin men continued. We knew this was not the way of the T'Iea legions, never have we sought to be such an aggressor, especially upon a far weaker force. We couldn't believe that soldiers we knew so well could break that code of training and reduce themselves to such actions. But because of this systematic policy of genocide the goblin men learnt to fear and hate us.
One day Te'Onolan'u'De'Hu'uinned announced that his sources had discovered what he thought to be the main centre of population of the goblin men, he was planning an all-out attack to teach them a lesson, "once and for all we will settle the goblin problem," he said. We were deeply shocked and many complained to Te'Onolan'u'De'Hu'uinned that this was not what we had been sent here for. Te'Onolan'u'De'Hu'uinned flew into a rage; he ordered the imprisonment of many that he saw opposing him. One such was the swordsman of our Trete'Y'Thego, he was taken from us and we have not seen him since. The raid on the goblins went ahead." Here Orln lowered his head into his hands and sighed, "it was inevitable, the goblin forces were wiped out, but not content with his victory, Te'Onolan'u'De'Hu'uinned ordered the complete burning of all the lands surrounding the encampment and the systematic murder of all goblins found. Both I and Neth'Gore were sickened to the core at this despicable act. We would have no part in it for it is one thing to fight another armed warrior, but quite a different thing to kill in cold blood the elderly and the innocent, the females and their whelps."
Thor could not believe what he was hearing; this was not something that he expected. The T'Iea legions had strict codes of honour and behaviour towards the enemy forces and especially towards the innocent and to civilians. To break these codes would be unimaginable, a heinous crime against the oppressed but also against the legion itself.
The expression upon his face must have given him away for Orln then said, "I see by your face that you are abhorred with this story. Then perhaps you would have done the same as myself and Neth'Gore and others. We deserted, we returned back to Ter'Hadsnefel, we gave ourselves up as deserters and we told our story in the court of the generals. Well to cut a long story short, we were divested of our rank and denied any further active duty in the legion whilst our final fate was decided. But thank the Maker, to our honour one general was on our side he fought for our case and even though he did not change the final verdict of dishonourable dismissal from the ranks he did manage to keep us from imprisonment and take on responsibility for us. That general even though he risked much, made sure that we remained trained and able minded over the period of time we were with him. We do not know even today why he took this action. But we are thankful to him for his mercy."
Thor thought for a while and said, "that general, the one who showed you mercy, I guess that he was The lady Solin's friend, Te'Onolan'u'De'Yiun?"
"Yes," was the simple answer.
Thor just nodded slowly in response. "Alright gentlemen, I thank you for your frankness and trust. It is a sorry tale with more than a few surprises. I do not know what we may find there in the east, but we are tasked with this and I intend that we carry out our orders to the best of our capability. We leave in the morning, I suggest you say your farewells and make good any outstanding business. We have a long journey ahead of us, as you well know. I will be grateful for your knowledge and experience to get us to our destination swiftly and safely."
## Chapter 18. First Class to Gwéldølĩn
That evening Nar'Allia found herself walking through the wide streets of Scienocropolis. She was being escorted to the airship that was waiting to transport the Pnook emissary and herself to Gwéldølĩn. She found herself travelling through a very prosperous looking part of the Pnook city accompanied by two Pnook guards, a personal escort of honour sent by the Pnook King himself. She looked up at the buildings that surrounded her. Tall, angular edifices, reaching high enough to scrape the sky, if she looked upwards for too long she found herself experiencing a sensation of falling, of losing her balance, it seemed like the building were tilting over above her, almost falling over to crush her. She shook her head. She wondered at the buildings being pointed out to her by the two escorts, the various purposes and uses to which they adhered, many of which Nar'Allia did not understand. Nar'Allia was in no doubt that the city may appear beautiful to some, in deed she could see herself that it possessed a certain attraction, yet it was so very different from her home. T'Iea cities had an architectural emphasis linked to the natural world, an organic component that defined their character. But here, there was nothing natural; it was totally a creation of the Pnook, without any naturalistic component whatsoever. But then the Rust Desert did not offer much in the way of natural beauty, at least not as she would describe. She had to admit she did find this a little unsettling. The buildings perhaps did have a certain beauty about them yet she found them also to be hard and sterile.
As she walked her mind wandered, she found her curiosity rising within her as to whom this emissary of the King may be, she had neither met the King or his emissary as yet. Her escorts had been sent with a sealed note. She |
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] | comply with, and that can vary from province to province. Even federal laws can be tricky to handle, with varying possession limits for different types of products, age and promotional restrictions, as well as public health regulations.
Cohen argued that in traditional retail markets these type of strict regulations don’t exist, so traditional providers don’t typically incorporate that in their POS software. But in the new legal cannabis market, regulation and compliance can be the difference between keeping or losing your license.
RELATED: CannabisFest explores how entrepreneurs can prepare for legalization
Cova calls its software “a dispensary POS designed for compliance.” It has built-in features for age verification, hours of operation compliance, as well as alerts for purchase limits that automatically calculate when a customer has exceeded the 30 grams limit.
The company’s software also helps with traceability throughout the production process, tracking batch numbers, as well as provides education for store employees as they try to help customers understand the different types of weed and various cannabis products.
In addition to its POS software, Cova also offers digital signage, express checkout, and touchscreen menus.
“We wanted to help our customers protect their hard-earned license and investment, that’s why we carefully designed our product to align with the nuances of cannabis laws and regulations,” Cogen stated. “Our POS is equipped with automated compliance features like age verification, sales limit alerts, and batch tracking to help prevent human error.”
Owning Ontario
Cova is currently partnering with at least 20 of the 25 Ontario cannabis retailers that won the lottery allowing them to open the first legal cannabis stores in the province.
“As the first legal retailer to open its doors in the city of Toronto, we have a duty to set an example for current and future retailers.”
When the Ontario PC government decided to go with a private model for the province’s brick-and-mortar cannabis stores it originally planned to offer an unlimited number of licenses for privately-owned stores. However, due to a shortage of cannabis product, the government decided to limit that number to 25. A lottery was held in January, and winners were told by the Alcohol Gaming Commission of Ontario (responsible for the OCRC), they should be ready to open on April 1.
There were nearly 17,000 lottery entrants in the lottery and most of the winners had no experience in the cannabis industry or running a store, according to the Ottawa Citizen.
When April 1 rolled around the majority of the chosen cannabis retailers were not prepared, only 10 passed all the requirements and were given the green light to open by the Alcohol Gaming Commission of Ontario. The stores authorized to open included three stores in Ottawa, two in Kingston, and one each in Toronto, Brampton, Burlington, London, and St. Catherines.
And a lot was involved in getting even those few doors open, making sure they had enough product, to making sure there was wifi, as well as ensuring they had a sales system that understood the complex cannabis industry. That’s where Cova stepped in.
Cova is the POS system behind at least six of the cannabis stores that actually opened on April 1. In Ontario, it is working with The Hunny Pot Cannabis Co., Ganjika, Hobo Recreational Cannabis Store, Fire & Flower, Spiritleaf, and Tweed, which all opened in the first day. It is also working with Canna Cabana, Superette, High Life, and Tokyo Smoke, as well as, Ameri, which opened its doors in Toronto this past Sunday.
Darren Bondar, president and CEO of Inner Spirit Holdings, the company behind the Spiritleaf franchise, noted that it spent over a year evaluating various POS systems before deciding to go with Cova for its Ontario stores, as well as its other locations across Canada.
Hunny Gawri, the owner of The Hunny Pot Cannabis Co., which was the first location to open in Toronto, noted that having a POS system created specifically for dispensaries, with built-in compliance, has already been valuable.
“As the first legal retailer to open its doors in the city of Toronto, we have a duty to set an example for current and future retailers, which means paying close attention to all of our vendors, from designers to POS software,” Gawri said.
Dominating the Canadian market
Cova isn’t just cornering the Ontario market, Cohen claimed that the startup is the POS system behind 70 percent of the legal cannabis brick-and-mortar locations across Canada.
“All these big players use Cova,” Cohen stated, noting that in each Canadian province it operates in, Cova has the most enterprise, as well as “mom-and-pop” customers.
Its system is currently helping run stores in five provinces. In Manitoba, it is working with Garden Variety, which has four locations, and in Alberta, it is working with a number of stores including Canadian franchise chains Spiritleaf, Fire & Flower, and Tokyo Smoke. In Saskatchewan, it is working with at least three locations, Lush Leaf Cannabis, Dreamweavers, and Modern Leaf. In BC, where Cova has its Canadian headquarters, it is operating in at least three locations as well.
Even when facing other Canadian POS giants like Lightspeed and Shopify, which has been expanding its retail presence of late, Cova appears to be cornering the market for cannabis POS systems.
The Canadian cannabis industry set to be worth $5 billion in 2021.
Cohen noted to BetaKit that along with the 20 Ontario stores that chose Cova, it is in talks with at least two others. Of the remaining three stores of the 25 that won the lottery, Cohen stated that two went with a competitor dispensary POS, and the other went with Shopify.
It is unclear which Ontario location Shopify is working with, and how many other locations across Canada are using its POS system. While the tech giant may have lost out on the brick-and-mortar side, it claimed victory in ecommerce, as the operating system behind Ontario’s online store. It was also chosen by three other provinces BC, Newfoundland, and Prince Edward Island to power their online retail sites, as well run some of the brick and mortar retail sales systems.
BetaKit reached out to Shopify for comment about its operations in the Canadian cannabis market but had not heard back by the time of publication.
RELATED: Cannabis software company Ample Organics announces Shopify integration
Fellow startup Greenline POS, which is based on Vancouver and founded in 2017, also offers a similar dispensary POS product. Its website stated that it works with hundreds of cannabis retailers across Alberta, Saskatchewan, and BC, servicing 30 percent of the cannabis retail market in the country.
The idea for Cova came out of parent company, iQmetrix, a POS company founded 22 years ago in Regina, that builds software for the cellular industry.
iQmetrix, wanting to use its experience in a regulated industry, decided to expand into new verticals. Cohen noted that it looked for retail verticals that had high growth opportunities and settled on cannabis. In 2016 Cova was born, as a subsidiary of iQmetrixs.
In November of 2018, Cova raised its first funding round that let it spin out of its parent company, raising $8 million from Regina-based venture capital and private equity fund, West CAP from Saskatoon. Cohen noted, however, that Covia is still majority owned by iQmetrixs.
While it was founded in Regina, Cova has its headquarters in Denver, Colorado and Canadian headquarters in Vancouver, with offices in Regina and Winnipeg. In the US, it works with retailers in California, Oklahoma, Washington, and Colorado.
The Canadian cannabis industry is set to be worth $5 billion in 2021, according to a report by cannabis research firm Brightfield Group. This is actually down from the firm’s previous estimate of $8 billion. This new estimate came from data collected of recreational cannabis sales post-legalization, which has been affected by a shortage of product availability.
While the market may now be smaller than once predicted Ontario’s brick-and-mortar retailers have yet to see that, with long lines and people camped outside waiting for them to officially open.
As for Cova and its POS system, Cohen stated April 1 was an exciting day.
“Legalization day on October 17 was very anti-climatic across the country,” he stated, “It was not what we hoped for and everything was compressed and minimized. So [Monday], it felt more like the big day, like legalization day.”
Feature image courtesy Cova via Twitter<?php
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] | s that Twitter is for professional and educational tweets, caved and voted to #SaveRyan one week and #SaveChris the next. Here is where it got interesting! My save tweets received a total of 305 and 430 retweets, respectively. Not to mention the fact that those retweets happened in under a minute! That got me to thinking. How can we turn education into a focused, national attention getting endeavor? And by that, I mean one that is found to be worthy of the level of attention that reality television, sporting events, and blockbuster movies garner. In fact, it sounds like we have our challenging investigation for educators around the globe.
Let me know how you would propose to answer the challenge. I look forward to hearing your thoughts via Twitter or in the comments here.Transient ischemic attacks due to atherosclerosis. A prospective study of 160 patients.
Patients with transient ischemic attacks (TIAs) due to atherosclerosis were studied by aortocranial arteriography. Onset of TIAs was before age 55 in 24% and between 55 and 64 in 47%. Men exceeded women by two to one. Of 160 patients, 77 were treated medically and 82 surgically. Five died in the immediate postoperative period. In the survivors, mortality has been the same in the medically and surgically managed groups. For patients with multiple lesions, surgical reconstruction of the carotid arteries was associated with very high surgical risk. In the medically treated group, anticoagulant therapy reduced the frequency of TIAs, but did not appear to protect patients from stroke. Mortality was 23% at four years, 57% of deaths being attributable to myocardial infarction and 38% to stroke.[MUSIC]
[SOUND] Reigns has no idea where he is,
trying to find his way up.
Here comes Reigns again.
Sheamus cover,
[SOUND] you gotta be kidding me!
>> We got a new Champion!
Sheamus is Champion.
>> Here is your winner and
the new WWE World Heavyweight Champion,
Sheamus!
>> Are you kidding me?
>> Cover him is for the title.
Cover Kurt, Brock, what are you doing?
Where in the hell's he going?
>> That's team Angle Charlie Haas and
Shelton Benjamin.
>> Woah, what?
Did you see that?
>> I don't know what I just saw.
>> That's not Kurt Angle in the ring.
No, Kurt Angle just
switched with somebody.
Wait a minute!
>> A roll up!
What's got Angle?
Yes, it is.
>> Here's and
still WWE champion, Kurt Angle!
>> [APPLAUSE] [SOUND]
>> [APPLAUSE]
>> My God.
>> No, Rick.
>> My God, no.
Hunter, what are you doing?
>> RIng the bell now.
Ring it.
>> Hunter, what are you doing?
This matchup's underway.
Bryan's out cold, Randy Orton, Randy Orton
has cashed-in Money In The Bank.
Randy Orton is the seven-time Champion.
>> Winner of this match and
new WWE Champion, Randy Orton!
[SOUND] Shannon can pull out a quick one,
you never know, come on man.
>> Okay.
>> The match is official,
the way by the way the bell rang and-
>> Look at this.
>> Shannon Moore planted
in the center of the ring.
>> Nasty power bomb there
by the WWE Champion.
>> What a clothesline.
>> This could be a record here, Cole,
the champion hammering away with
another one to the head of Shannon.
The cover, hook to the leg and
this one if over, mercifully.
>> What an amazing championship event.
The champ.
[SOUND]
>> Rings the bell,
this championship reign is over.
Champion!
>> John Cena, wait cover!
Cover by Mahal!
>> No!
>> Jinder Mahal!
>> Did he get him?
>> Mahal [INAUDIBLE]
>> Here is the winner and
still the WWE champion, Jinder Mahal!
>> It is official!
[MUSIC]
[SOUND] [NOISE]
>> Match up underway.
Rogue kick to the skull!
>> [APPLAUSE]
>> Sheamus into the cover,
hooks the leg, see you bye Zach Ryan.
What a joke.
>> The winner of this match, and
still WW WWE Champion, Sheamus!
>> When you said it just takes three
seconds did you know you were gonna be
talking about the length of this match?
[MUSIC]
[SOUND]
>> [APPLAUSE]
>> Hulk Hogan's in the ring!
>> Ding ding!
The crowd wants him to go for it.
And now Fuji reaching back
into his kimono there.
And he's got more of that salt or
whatever.
Right in the eyes of Yokozuna!
Hogan knowns Fuji down.
Hogan with clothesline and
down goes Yokozuna.
Hogan back down.
Hogan Undercover.
[INAUDIBLE] I can't believe this.
[MUSIC]
[SOUND]
>> Look at Cena, hands up, fist clenched,
ready to go.
>> John Cena says go,
in a right hand stuns Batista momentarily.
>> Looks like he was
embarrassed by that right hand.
>> [INAUDIBLE]
Spear.
>> My God, the animal is unleashed here.
>> No.
>> Yeah.
>> Batista bomb!
>> Bone rattling.
>> One, two, three!
>> You gotta be kidding me!
>> Yes!
>> Batistia is the new WWE champion!
[MUSIC]
[NOISE]
>> [APPLAUSE]
>> The winner of this [INAUDIBLE]-
>> [APPLAUSE]
>> Diesel!
[SOUND]
>> [APPLAUSE]
>> And
Brock Lesnar quickly with Kofi Kingston,
into an F-5!
An F-5 by Lesnar, here's the cover,
we got a new champion.
[SOUND] We have a new champion.
>> Here is your winner and
the new WWE Champion, Brock Lesnar!
>> Sudden impact by The Beast!
>> That's got to be a record of some sort.
[MUSIC]
Abstract
Purpose
The inclusion of patient-reported outcome (PRO) questionnaires in prognostic factor analyses in oncology has substantially increased in recent years. We performed a simulation study to compare the performances of four different modeling strategies in estimating the prognostic impact of multiple collinear scales from PRO questionnaires.
Methods
We generated multiple scenarios describing survival data with different sample sizes, event rates and degrees of multicollinearity among five PRO scales. We used the Cox proportional hazards (PH) model to estimate the hazard ratios (HR) using automatic selection procedures, which were based on either the likelihood ratio-test (Cox-PV) or the Akaike Information Criterion (Cox-AIC). We also used Cox PH models which included all variables and were either penalized using the Ridge regression (Cox-R) or were estimated as usual (Cox-Full). For each scenario, we simulated 1000 independent datasets and compared the average outcomes of all methods.
Results
The Cox-R showed similar or better performances with respect to the other methods, particularly in scenarios with medium–high multicollinearity (ρ = 0.4 to ρ = 0.8) and small sample sizes (n = 100). Overall, the Cox-PV and Cox-AIC performed worse, for example they did not select one or more prognostic collinear PRO scales in some scenarios. Compared with the Cox-Full, the Cox-R provided HR estimates with similar bias patterns but smaller root-mean-squared errors, particularly in higher multicollinearity scenarios.
Conclusions
Our findings suggest that the Cox-R is the best approach when performing prognostic factor analyses with multiple and collinear PRO scales, particularly in situations of high multicollinearity, small sample sizes and low event rates.
Efficace, F., Innominato, P. F., Bjarnason, G., Coens, C., Humblet, Y., Tumolo, S., et al. (2008). Validation of patient’s self-reported social functioning as an independent prognostic factor for survival in metastatic colorectal cancer patients: results of an international study by the Chronotherapy Group of the European Organisation for Research and Treatment of Cancer. Journal of Clinical Oncology, 26(12), 2020–2026.CrossRefGoogle Scholar2 - 2*l + 8*l**2 + 4*l + 8*l**2 to the form x + w*l**2 + a*l and give w.
-1
Rearrange -i**2 + 3*i**2 - i**2 + (2*i + 0*i + 0*i)*(-i + i - i) + (-1 + 5 - 2)*(0*i**2 - 3*i**2 + 6*i**2) to the form b*i |
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] | h}}
\frac {\mu (\mathbf d)}{[q,d^{*k}]}+\mathcal O\left (t\sideset {}{^*}\sum _{d_1\cdot \cdot \cdot d_r>Y}
\frac {1}{d^{*k}}+\sum _{d_1\cdot \cdot \cdot d_r\leq Y}1\right )
\\ &&\hspace {15mm}=\hspace {4mm}t\eta (q,a)+\mathcal O\left (tY^{1-k+\epsilon }+Y^{1+\epsilon }\right )\end{aligned}$$ from and Lemma \[et\] (ii), so becomes $$\begin{aligned}
&&\sum _{n\leq t\atop {n\in \mathcal R\atop {n\equiv a(q)}}}1
=t\eta (q,a)+\mathcal O\bigg (tY^{1-k+\epsilon }+Y^{1+\epsilon }+t^\epsilon \Big (tY^{1-k+\epsilon }+t^\Delta \Big )\bigg )\end{aligned}$$ which gives (i) on choosing $Y=t^{1/k}$.\
\
(ii) From we have for a parameter $Y\leq t^{1/k}$ to be chosen $$\begin{aligned}
\label {radio2}
\sum _{n\leq t\atop {n\in \mathcal R\atop {n\equiv \nu (q)}}}1&=&
\sideset {}{^*}\sum _{d_1\cdot \cdot \cdot d_r\leq Y}\mu (\mathbf d)
\mathcal N^{q,\nu }_{\mathbf d;\mathbf h}(t)
+\mathcal O\left (\sideset {}{^*}\sum _{d_1\cdot \cdot \cdot d_r>Y\atop {(q,\mathbf d^k)|\nu +\mathbf h}}
\sum _{n\leq t\atop {n\equiv -\mathbf h(\mathbf d^k)\atop {n\equiv \nu (q)}}}1\right ).\hspace {10mm}\end{aligned}$$ The main term here is $$\begin{aligned}
\sideset {}{^*}\sum _{d_1\cdot \cdot \cdot d_r\leq Y\atop {(q,\mathbf d^k)|\nu +\mathbf h}}\mu (\mathbf d)
\left (\frac {t}{[q,d^{*k}]}+\mathcal O(1)\right )&=&t\sideset {}{^*}
\sum _{d_1,...,d_r\atop {(q,\mathbf d^k)|\nu +\mathbf h}}\frac {\mu (\mathbf d)}{[q,d^{*k}]}
+\mathcal O\left (t\sideset {}{^*}\sum _{d_1\cdot \cdot \cdot d_r>Y\atop {(q,\mathbf d^k)|\nu +\mathbf h}}
\frac {1}{[q,d^{*k}]}+\sum _{d_1\cdot \cdot \cdot d_r\leq Y}1\right )
\\ &=&t\eta (q,\nu )+\mathcal O\left (t\sideset {}{^*}\sum _{d_1\cdot \cdot \cdot d_r>Y\atop {\nu \equiv -\mathbf h
\left ((q,\mathbf d^k)\right )}}\frac {1}{[q,d^{*k}]}+Y^{1+\epsilon }\right )\end{aligned}$$ from , therefore implies $$\begin{aligned}
\label {gaga}
\sum _{n\leq t\atop {n\in \mathcal R\atop {n\equiv \nu (q)}}}1-
t\eta (q,\nu )&\ll &\sideset {}{^*}\sum _{d_1\cdot \cdot \cdot d_r>Y\atop {\nu \equiv -\mathbf h\left ((q,\mathbf d^k)\right )}}\left (
\sum _{n\leq t\atop {n\equiv -\mathbf h(\mathbf d^k)\atop {n\equiv \nu (q)}}}1
+\frac {t}{[q,d^{*k}]}\right )+Y^{1+\epsilon }\notag
\\ &=:&\mathcal T_Y(q,\nu )+Y^{1+\epsilon }.\end{aligned}$$ In general for general positive functions $f,g$ and $S:=\sum _{d}\left \{ f(d)+g(d)\right \} $ it is easy to establish that $S^2\ll \sum _{d,d'}\left \{ f(d)f(d')+g(d)g(d')\right \} $. Therefore $$\begin{aligned}
\sum _{\nu =1}^q|\mathcal T_Y(q,\nu )|^2&\leq &
\sideset {}{^*}\sum _{d_1\cdot \cdot \cdot d_r>Y\atop {d_1'\cdot \cdot \cdot d_r'>Y}}
\sum _{\nu =1\atop {\nu \equiv -\mathbf h(q,\mathbf d^k)\atop {\nu \equiv -\mathbf h(q,{\mathbf d'}^k)}}}^q\left (
\sum _{n,n'\leq t\atop {n\equiv -\mathbf h(\mathbf d^k)
\atop {n'\equiv -\mathbf h({\mathbf d'}^k)\atop {n\equiv n'\equiv \nu (q)}}}}1+\frac {t^2}{[q,{d^*}^k][q,{d'}^{*k}]}\right ).\end{aligned}$$ and the congruence conditions in the $\nu $ sum amount to one congruence modulo $$[(q,d_1^k),...,(q,d_r^k),(q,{d_1'}^k),...,(q,{d_r'}^k)]=\frac {(q,d^{*k})(q,{d'}^{*k})}{(q,d^{*k},{d'}^{*k})}$$ so that the whole $\nu $ sum is $$\leq \sum _{\nu =1}^q\sum _{n,n'\leq t\atop {n\equiv -\mathbf h(\mathbf d^k)
\atop {n'\equiv -\mathbf h({\mathbf d'}^k)\atop {n\equiv n'\equiv \nu (q)}}}}1
+\frac {t^2q(q,d^{*k},{d'}^{*k})}{[q,{d^*}^k][q,{d'}^{*k}](q,d^{*k})(q,{d'}^{*k})}
=\sum _{n,n'\leq t\atop {n\equiv -\mathbf h(\mathbf d^k)
\atop {n'\equiv -\mathbf h({\mathbf d'}^k)\atop {n\equiv n'(q)}}}}1+\frac {t^2(q,d^{*k},{d'}^{*k})}{qd^{*k}{d'}^{*k}}$$ and therefore $$\begin{aligned}
\sum _{\nu =1}^q|\mathcal T_Y(q,\nu )|^2&\leq &
\sideset {}{^*}\sum _{d_1\cdot \cdot \cdot d_r>Y\atop {d_1'\cdot \cdot \cdot d_r'>Y}}
\left (\sum _{n,n'\leq t\atop {n\equiv -\mathbf h(\mathbf d^k)
\atop {n'\equiv -\mathbf h({\mathbf d'}^k)\atop {n\equiv n'(q)}}}}1+\frac {t^2(q,d^{*k},{d'}^{*k})}{qd^{*k}{d'}^{*k}}\right ).\end{aligned}$$ Since for any $N\in \mathbb N$ $$\sum _{q\leq \gamma }\frac {(q,N)}{q}\ll N^\epsilon (\log \gamma +1)\ll N^\epsilon \gamma ^\epsilon$$ we see, on separating the terms with $n=n'$ since for these no divisor estimate is applicable, that $$\begin{aligned}
\label {huh}
\sum _{q\leq \gamma }\sum _{\nu =1}^q|\mathcal T_Y(q,\nu )|^2&\ll &\sideset {}{^*}
\sum _{d_1\cdot \cdot \cdot d_r>Y\atop {d_1'\cdot \cdot \cdot d_r'>Y}}\left (t^\epsilon
\sum _{n,n'\leq t\atop {n\equiv -\mathbf h(\mathbf d^k)\atop {n'\equiv -\mathbf h({\mathbf d'}^k)}}}1
+\gamma \sum _{n\leq t\atop {n\equiv -\mathbf h(\mathbf d^k)\atop {n\equiv -\mathbf h({\mathbf d'}^k)}}}1
+\frac {t^2(d^{*k},{d'}^{*k})^\epsilon \gamma ^\epsilon }{d^{*k}{d'}^{*k}}\right )\notag
\\ &\ll &t^\epsilon \left (\left (\hspace {1.5mm}\sum _{d_1\cdot \cdot \cdot d_r> |
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] | ane Curl was originally committed to prison following a February 24, 1976, conviction for assault with a deadly weapon. (Pen. Code, § 245.) Under the Indeterminate Sentence Law (ISL), applicable at that time, the Adult Authority fixed his term at 20 years.
On April 22, 1977, respondent committed and was subsequently convicted of the second degree murder of a fellow inmate while incarcerated at the California Medical Facility, Vacaville. (Pen. Code, § 187.) His ISL term was then set at five years to life, and this sentence was ordered to be served concurrently with the prior assault.
After the passage of the determinate sentence law (DSL) (Pen. Code, § 1170 et seq.), respondent's term was recalculated under the DSL to be a concurrent term of six years pursuant to section 1170.2.
Six months later, while serving the concurrent sentences at the state prison in Soledad, respondent stabbed two inmates. He pleaded guilty to assault with a deadly weapon (Pen. Code, § 4501) and was sentenced to the upper base term of four years, which was ordered to run consecutively to the terms he was presently serving.
Relying on People v. McCart, supra, 32 Cal.3d 338, respondent petitioned the superior court for a writ of habeas corpus. He claimed that Penal Code section 1170.1, subdivision (c) requires that all subsequent terms for in-prison offenses which are ordered to be served consecutively be calculated at one-third of the middle base term as set forth in subdivision (a) of that section. Concluding that the situation in McCart was similar to the instant matter, the trial court granted the writ petition. In light of the difference discussed below, we read McCart to reject the calculation respondent espouses.
*239 In People v. McCart, supra, 32 Cal.3d 338, the defendant was convicted of an offense while in prison and was sentenced to a consecutive six-year term. Two months later defendant was convicted of a second in-prison offense, possession of a deadly weapon by a prisoner (Pen. Code, § 4502), which the statute required to be served consecutively. The trial court imposed the full upper base term of four years to be served consecutively to the prior terms.
The defendant, McCart, argued that former Penal Code section 1170.1, subdivision (b), renumbered as subdivision (c), required that the length of consecutive terms for multiple in-prison offenses be calculated according to the principal term/subordinate term formula contained in subdivision (a). (People v. McCart, supra, 32 Cal.3d at p. 341.) The Supreme Court agreed, rejecting the People's main argument that the statute reflected a legislative intent to provide full consecutive terms for in-prison offenses where the sentences are imposed in separate proceedings. (Ibid.)
The People relied on the language of subdivision (c) which provided "`the term of imprisonment for all such convictions [which such person is required to serve consecutively] shall commence from the time such person would otherwise have been released from prison.'" (Id., at p. 342.) However, the court noted that this argument overlooked the last sentence of the section which read: "`The provisions of this subdivision shall be applicable in cases of convictions of more than one offense in different proceedings, and convictions of more than one offense in the same or different proceedings.'" (Id., at p. 343.)
The court concluded that when these provisions were read together it called for "computation of a single term of imprisonment for all convictions of felonies committed in prison and sentenced consecutively, whether multiple convictions occur in the same court proceeding or in different proceedings." (Ibid., italics added.) All contemporaneous, or nearly contemporaneous, consecutive in-prison offenses are to be calculated in the same manner as for nonprison offenses.
The instant matter differs from the facts in McCart in one important respect; here, respondent was sentenced to only one consecutive term for his second in-prison offense, not two as in McCart.
Penal Code section 1170.1, subdivision (c) reads as follows: "In the case of any person convicted of one or more felonies committed while such person is confined in a state prison, or is subject to reimprisonment for escape from such custody and the law either requires the terms to be served consecutively or the court imposes consecutive terms, the term of imprisonment *240 for all such convictions which such person is required to serve consecutively shall commence from the time such person would otherwise have been released from prison. If the new offenses are consecutive with each other, the principal and subordinate terms shall be calculated as provided in subdivision (a), except that the total of subordinate terms may exceed five years. The provisions of this subdivision shall be applicable in cases of convictions of more than one offense in different proceedings, and convictions of more than one offense in the same or different proceedings." (Italics added.)
Giving effect to all the language in the statute (Gay Law Students Assn. v. Pacific Tel. & Tel. Co. (1979) 24 Cal.3d 458, 478 [156 Cal. Rptr. 14, 595 P.2d 592]), it seems clear that the Legislature intended that in-prison offenses, sentenced consecutively, should begin to run from the expiration of the prior term. As applied to the instant matter, the prior term reflects respondent's concurrent sentences for assault with a deadly weapon and second degree murder. It is the Legislature's intention to standardize only those in-prison offenses which are sentenced consecutively. Since respondent received a concurrent sentence for his first in-prison crime of murder, he was not prejudiced and does not fall within the harmonizing purpose of the statute.
This reading is consistent with the interpretation of the statute given by the McCart court: "Read together these provisions call for computation of a single term of imprisonment for all convictions of felonies committed in prison and sentenced consecutively, whether multiple convictions occur in the same court proceeding or in different proceedings. That this term is to commence when the person would otherwise have been released emphasizes that the new term is to be fully consecutive to the term already being served: i.e., that it must commence at the end of the longest of the prisoner's previously imposed terms. [Fn. omitted.]" (People v. McCart, supra, 32 Cal.3d at p. 343, italics added.)
Applying the foregoing rationale to the instant matter, it seems clear that the first consecutively sentenced in-prison offense; i.e., assault, is to be a full term which commences at the end of respondent's concurrent term. Accordingly, it was error to reduce the sentence for the in-prison assault to one-third of the middle base term; i.e., one year, instead of the four-year principal term originally imposed.
(2) The People next argue that section 1170.1, subdivision (c) does not apply here since the in-prison offenses were committed in different counties. We disagree. Although the murder was committed while Curl was incarcerated at the California Medical Facility in Vacaville, Solano County, and *241 the more recent assault with a deadly weapon was committed while Curl was confined to the state prison in Soledad, Monterey County, it is irrelevant, as the McCart court pointed out, whether the convictions occurred in the same court proceeding or in different proceedings. (People v. McCart, supra, 32 Cal.3d at p. 343.) Likewise, the overriding purpose of uniformity and proportionality in prison terms would not be achieved if such terms were determined by the respondent's fortuity to have committed the crimes in the same county. (Id., at p. 346.)
The order granting the petition for a writ of habeas corpus is reversed. The original sentence imposing a full consecutive term of four years remains in effect.
King, J., and Haning, J., concurred.
A petition for a rehearing was denied December 23, 1983, and the opinion was modified to read as printed above.
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“There are two novels that can change a bookish fourteen-year old’s life: The Lord of the Rings and Atlas Shrugged. One is a childish fantasy that often engenders a lifelong obsession with its unbelievable heroes, leading to an emotionally stunted, socially crippled adulthood, unable to deal with the real world. The other, of course, involves orcs.” ― Paul Krugman
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Hi, I'm Bret. I'm a very Progressive Liberal. I believe in the truth behind science and mathematics. I believe supposed "creationists" are just too ignorant to understand actual science, and fall back to their magic storybook because real science is too hard for their itsy-bitsy lizard brains. I believe in equality for all people; straight, gay, bi, trans, white, black, brown it does not matter. We are all humans on this Earth for a limited time. Celebrate diversity and enjoy with other's bring to your life. End of story. ;-)
Neil Cavuto, for instance, hosted Gilchrist on his Fox News show Oct. 16, and mostly blew sunshine up Gilchrist's butt, talking about how he was a war hero, and didn't those mean students know he had fought for their free-speech rights, blah blah blah. Then he added:
Cavuto: What the kids were saying in those pre-law classes was that you were going around, rounding up at the border illegal immigrants, was tantamount to, uh, physical abuse, some of them were saying. And that you were advocating violence. Now, I know that's not your schtick, or what you're saying, and it's |
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3548,
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] | likely coming up the main road—though he was prepared if they came over either ridge, too. The half-deads would try to swarm over the cops in the Hollow, and then Justinia Malvern would make her dramatic entrance, draining any survivors of blood before she went for the main prize. The paddy wagon. It stood in the middle of the clearing just waiting to be torn open so Malvern could get at the vampire hunter within.
Of course Fetlock didn't plan to actually let that happen. His intention was to have his windbreakers engage the half-deads with a withering cross fire, then let Malvern come swooping in right into the sights of half a dozen snipers. Even then he had backup plans. The best sharpshooters he had might not be enough to take down a vampire, and he knew it—vampires were devilishly fast, and snipers were most effective against stationary targets. He claimed to have some surprises hidden in his mobile command center, things he wouldn't tell Clara and Glauer about. He also had his helicopter, though what it could do remained to be seen. "We had helicopters at Gettysburg," Glauer had told him, arguing patiently while Fetlock just gloated. "Didn't help much."
"You used them there as support vehicles, mostly for intelligence gathering. Trust that I paid attention when I read your reports, Special Deputy."
Glauer had shrugged and asked no more questions.
So that was the trap, which Clara had to admit sounded formidable. Meanwhile Darnell was up on the ridges making sure it didn't prove too impregnable, that it didn't scare Malvern off before she even got into Fetlock's crosshairs. Fetlock and Urie Polder had figured out a way to make it look like the cops had foolishly ruined their own first line of defense. Rather than just take down the cordon of teleplasm and the perimeter of shrieking bird skulls, Darnell would tear down a few of the teleplasmic sheets as if he had been forced to do so to sneak in when he first started spying on the Hollow (he had actually been able to bypass them easily), then kick dirt over a couple of the skulls as if he'd carelessly disturbed them. They were fragile charms and easily disabled, and it was possible to make it look like he'd done so by accident. As a result of these efforts there would be a clear path for the half-deads to take through the defenses and right into Fetlock's traps, but it wouldn't look like they'd been given an engraved invitation.
By the time the sun set behind the western ridge, everything was in place. As twilight fell across the tree-lined slopes that hemmed them in on either side, Clara felt the muscles of her back stiffen and tense. She watched the last rays of red sunlight cut through the puffy clouds as if she would never see them again.
"Won't happen right away," Glauer told her.
"I know," she replied. It was very unlikely that Malvern would strike exactly at sunset. She had to sleep all day in her coffin. They had no idea where that coffin might be, but it probably wouldn't be within ten miles of the Hollow. So she would have to travel to the trap, which might take ten minutes or it might take hours. And she was far too clever to stick to any expected timetable. She would strike when they least expected it. Which meant they had to expect it to come at any moment.
Glauer and Clara kept wandering back and forth across the clearing, even as it grew so dark they could barely make out each other's faces in the twilight. Even when they started tripping on tree roots and rocks. They had not been given orders to stop.
Every inch of Clara's skin prickled with fear. Every pore of her body exuded greasy fear sweat, though the temperature dropped rapidly as the darkness grew complete. Every instinct she had told her to run away.
"Might not happen tonight," Glauer said, his voice strangely loud in the dimness.
"You know it will," she said.
Still. Fifteen minutes passed in full darkness, and nothing happened.
An hour passed, and nothing happened.
Two hours.
"Oh my God, come on already!" Clara screamed, trying to break the tension. Nearby one of the windbreaker cops grabbed his gun and trained it on her, his eyes wide, his back heaving as he sucked in breath. Apparently she wasn't the only one going crazy with the waiting.
She tried to control herself.
She nearly jumped out of her skin when a radio crackled somewhere behind her. She spun around and saw Fetlock leaning out of the back of the mobile command center. Yellow light painted half his face. He had a walkie-talkie in one hand and he brought it up close to his mouth.
"Unit Nine? Say again," he ordered.
"Unit Nine reporting contact," the walkie-talkie replied. The man on the other end of the connection sounded tense and harried. "We have multiple subjects, moving through the tree line, at locations Whiskey Three and again at Yankee One. Repeat, we have—"
The man fell silent. Clara couldn't move a muscle. All she could do was stand there and watch Fetlock's face. Nothing in it changed.
"Unit Nine, say again," Fetlock ordered.
But Unit Nine didn't repeat his information. Instead he started screaming, a terrible, tinny little sound coming from the walkie-talkie. The sound of a man being torn to pieces while he was still alive.
There was no question. The attack was starting.
## 42.
The Fed reached down and lowered the volume on his radio, but Clara knew the man up on the ridge was still screaming. She could hear it directly now, floating on the air.
"Everyone stay frosty. Maintain your posts," Fetlock called to the cops in the Hollow. "This is what we planned for. What we've been training for the last month."
There were a few cries of assent, of determination. Most of the cops just kept their heads down. They'd heard the stories. They knew what happened when the police tried to fight vampires.
So did Clara. "Glauer," she said. "Glauer, this is going to get bad."
"I know," he told her. "Now shut up."
She started to protest, but she knew he was right. Worrying about what came next wouldn't change it. Talking about it only made the apprehension worse.
"All sniper units, report in," Fetlock said into his walkie-talkie. One by one, eight men called in to report no contact.
Up on the ridge the screaming stopped. Not as if the man up there had been finished off. Just as if he'd run out of breath and couldn't make any more noise.
"He should bring up the helicopter—get a better visual on the situation—light some flares," Clara muttered. She couldn't help herself. "He should give us guns."
"I know," Glauer said again.
"Ground units, report in," Fetlock said.
One by one the SWAT troopers and the windbreakers started calling in. Just confirming they were still alive.
"Infrared, give me a report," Fetlock said.
"No contact. No movement," the walkie-talkie said.
"IR? Why is he using IR? Half-deads don't radiate heat. He should be using night vision instead, so—"
"I _know_ ," Glauer insisted.
Then he grabbed her arm. He must have seen something. Something Clara missed. Off to one side of them, a windbreaker cop started turning around, bringing his gun up. Something snatched him out of the dark and pulled him back into the woods, so fast he didn't have a chance to report on it.
A moment later he started screaming. He was not fifteen yards away from where Clara and Glauer stood.
The SWAT troopers opened fire on where he'd been. There was no way they could be sure they weren't shooting their own man, but they must have had orders to shoot anyway. Carbines barked and spat as bullets tore through the dark trees on that side of the Hollow. "Now, lights!" Fetlock called, and a bank of floodlights on top of the mobile command center swiveled in that direction and flared to life.
Clara just had time to see a skinless face peering out from between two tree trunks before it flickered away, too fast to follow. More bullets snapped off in the direction of the half-dead, but it was long gone.
"Ground units, fire at will," Fetlock called.
But there was nothing to shoot.
The man in the woods had stopped screaming almost at once. Clara listened hard for any kind of movement in those trees, peered into the shadows for any human-shaped silhouette. But there was nothing.
"Guerrilla tactics," Glauer said.
"What?" Clara demanded.
"She knows that Fetlock wants a frontal assault. A big pitched battle. She won't give him that. She'll pick us off one by one. This isn't |
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] | the Credit Information Bureau and offer legal, debt collection, personal bankruptcy and financial liquidity advice. Marshal Lion Finance offers guidance with bankruptcy proceedings, both company and personal, while at the same time financing the concurrent growth and projects using financial instruments selected specifically for the particular client.
— experts at this division offer financial sector-related advice aiming to produce the best possible outcome for any client. This can include a range of financial services and loans. Additionally, Marshal Lion Finance will help the client improve their credit score with the Credit Information Bureau and offer legal, debt collection, personal bankruptcy and financial liquidity advice. Marshal Lion Finance offers guidance with bankruptcy proceedings, both company and personal, while at the same time financing the concurrent growth and projects using financial instruments selected specifically for the particular client. Marshal Lion Group — many years’ experience in the area of business strategy and planning allows the Marshal Lion Group to analyze a company’s situation thoroughly and propose customized solutions for the betterment of said situation. Our team of experts helps implement changes to the operations of a company aimed at optimizing them. Additionally, Marshal Lion Group helps clients set up corporate groups and then remains with the client if additional consultations are necessary. Good and effective help with planning involves setting specific objectives for a given project and then monitoring the process. This includes financial analysis, risk assessment, and improving the prospects of bountiful returns through financial and management optimization. Marshal Lion Group offers ready-to-go strategies developed based on analysis of a given company, its potential and potential drawbacks.
Dedicated Online Platform
Marshal Lion experts and its dedicated digital platform will make it much easier for investors (so far unable to do so) to invest in the non-bank loans market and profit from it. Everybody benefits from our modern and decentralized approach to finances which allows for the reduction in the number of middlemen, lower cost and less misunderstanding. Automation makes every process faster, cheaper and much, much safer.
As part of our dedicated platform, Marshal Lion will make it possible to use its token to invest in the company’s products. Owing to smart contracts and decentralization allowing for unilateral analysis of any project by any potential investor, the safety of the process is guaranteed.
The established market position enjoyed by Marshal Lion was won through over 3.000 loans granted to our clients and is testament to our experience, expertise and very deep understanding of the subject matter together with the associated legal and financial intricacies. Our token is, therefore, a boon for an investor and an outstanding diversifying asset for any wallet.
WEB: https://marshalliongroup.com
Facebook: https://www.facebook.com/Marshal-Lion-Group-1764544916981990/
Instagram: https://www.instagram.com/marshalliongroup_com/
LinkedIn: https://www.linkedin.com/in/marshal-lion-group-18a0a018a/ Twitter: https://twitter.com/marshal_lion
Medium: https://medium.com/@marshal_lion
Reddit: https://www.reddit.com/user/MarshalLionGroup
Telegram: https://t.me/marshal_lionNFL Draft Report
Tannehill headlines five visitors to One Bills Drive
With the deadline to bring prospects for the 2012 NFL Draft looming on Wednesday, the Buffalo Bills brought in what will likely be their final pre-draft visitors to team facilities on Tuesday.
According to BuffaloBills.com, Texas A&M quarterback Ryan Tannehill, South Carolina defensive end Melvin Ingram, Mississippi State defensive tackle Fletcher Cox, South Carolina cornerback Stephon Gilmore and Oklahoma cornerback Jamell Fleming all made the visit to One Bills Drive.
If this were two months ago, Ingram visiting would probably be the headline. But with both Mario Williams and Mark Anderson signed to the Bills via free agency, combined with how Buddy Nix views the defensive end class at the top of the draft, it doesn't appear as though he'll be the player selected at 10.
Gilmore is an intriguing case. Numerous reports have him shooting up draft boards. Peter King of Sports Illustrated thinks he could go as high as seventh to Jacksonville. With the Bills in need of a cornerback, he could be on the short list of candidates the Bills could think about for their selection at tenth overall.
Fleming is a second-tier type of cornerback that could be had on the second day of the draft at some point. As for Tannehill, you can read about how to look in to his visit to Buffalo here.
All in all that's 26 total visits that were reported. Teams are allowed a grand total of 30, so it's very possible four players snuck in and out of Buffalo without it being reported.Q:
How to disable Client-side Validation for an XPage?
I know i can disable for the server or application in the xsp.properties via:
xsp.client.validation=false
And at the control level via:
disableClientSideValidation="true"
Short of setting disableClientSideValidation for each control, is there any way to disable at the XPage level?
A:
Please try the following:
<?xml version="1.0" encoding="UTF-8"?>
<xp:view xmlns:xp="http://www.ibm.com/xsp/core">
<xp:this.properties>
<xp:parameter name="xsp.client.validation" value="false" />
</xp:this.properties>
</xp:view>
Q:
startActivityForResult(Intent, int) what is the purpose of the integer argument
I am following a tutorial that uses "startActivityForResult" function. I know why this function is used and if we want to use the returned data, we use onActivityResult() function. The thing that I wana know is, why do we pass an Integer to startActivityForResult() function? And where is it used?
Thanks for your kind help!
A:
When the Activity that you're starting finished, that second argument is passed to the method onActivityResult() of the calling Activity. This is to distinguish different results from one another.
You may have a case where an Activity needs to call several others for results, and by specifying a unique int for each of them, you can determine the correct thing to do when you get a result.
Edit: Here's an example.
Suppose you have a screen (Activity A) where you choose a picture from your gallery, and you choose a friend to send it to. You'll start an activity to pick a picture from the gallery on a button click, and maybe you also have a "friend picker" activity which you can also start from Activity A.
You want both of those activities to return the data the user selected. onActivityResult() will get called on Activity A when the user finishes with the two activities described above. By specifying the requestCode for startActivityForResult() for the gallery activity, and your "friend picker", you know what to do in onActivityResult().
Also, note that you don't need a complicated scheme for requestCode. You could just pass in the values 1 and 2 for the gallery and friend picker, respectively.
{.NET + SQL_Server + Azure + devLeadership + technology}
Menu
Rocky Lhota at CNUG
I had a chance to ask Rocky a couple of questions that had been bugging me about CSLA.
1) He agreed that using the method of multiple result sets in datareader is not really a good idea in some instances, where a dataset would be much more useful.
2) He suggested that you should usually not have an object that is sometimes a child and sometimes a parent. I am not sure I agree with idea. I believe I understand his point that if you are dealing with a Project object that has a collection of Employees assigned to it, you probably don’t need the Employees to be as complex as if you were dealing with an Employee who is assigned to a bunch of Projects, but at the same time you are talking about writing 2 classes with 2 sets of data access scripts, vs 4 classes and 4 sets of data access. But, he said that there are techniques for making a business object be both a parent and a child. This is apparently detailed in Ch 7.
3) He mentioned that people have built UI Frameworks that run on top of CSLA. I will have to look into this.
4) He was showing an example using an ASP.NET MultiView control, looked like a great way to enable multiple views of the same data.
5) I didn’t get a chance to ask him about serialization and deserialization of classes that have small differences. For example if you serialze an object and use the same byte array to deserialize a similar class, will it blow up if small changes are made, like you add a public property? I will have to try this out myself.
In all, Rocky was a very good speaker. Very engaging, funny, and on point.
Oh and I won the raffle at the end, to get a copy of his book, the one I just paid 60 bucks for :-).package handlers
import (
"fmt"
"net/http"
"net/url"
"github.com/docker/distribution"
dcontext "github.com/docker/distribution/context"
"github.com/docker/distribution/reference"
"github.com/docker/ |
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] | here, Yayan. What do you think is going to happen if you don't cooperate with us?"
"What do you think will happen if I do?"
"We can protect you," Lincoln said. "Hide you. Give you a new life. Anything you want."
Prakoso just stared back at Lincoln. "Sir, all these things you say. Which of them do you believe I haven't heard ten thousand times before now? From men just like you."
"Surely it's better than the alternative."
"No, sir. For me, they are the same. All the same," Prakoso said. "Prison."
"Prison is what I'm trying to protect you from, Yayan. Hanging out with us, I know it's not your _first_ choice, but trust me, this is an all-expenses paid vacation in paradise compared to what's going to happen if I have to release you to the people who _really_ want you. I'm taking a lot of heat for you right now. I've got all kinds of threats coming my way on your account. I'm spending all my personal capital keeping you here, and I'm just about out. Pretty soon it's going to be out of my hands, and chances are someone's going to come take you away and they're going to stick you in a hole somewhere on a hop out in deep space. If that happens, _when_ that happens, you're going to realize your old friend Lincoln here was telling you the truth, that he was the best chance you had, and it's going to be too late. Once you're gone, there's nothing else I can do for you. But if you help me now, I'll do everything in my power to make it right for you."
"I cannot help you," Prakoso said. And he looked down at his hands in his lap, and then added, "My part is done. They asked nothing of me more, not for days. Weeks." He shrugged.
It was such a small moment, Lincoln almost missed it. But he realized that it was the first time Prakoso had acknowledged in any way that he'd been working for someone. Lincoln knew he had to tread carefully now, to coax the information out without overplaying it, without giving any signal to Prakoso that he was slipping.
"Then why were they still holding you?" he said. "If your part was done?"
"Control," Prakoso said.
"And that was what you agreed to? Part of the deal?"
"It is never part of the deal," Prakoso said. "And yet, always." He smiled sadly then and took a deep breath. And his defenses came down. "This is not the life I wanted. Not what I meant to choose," he continued, and shook his head. "I just wanted to solve interesting problems."
And that's how it usually happened, how interrogations most often turned for Lincoln; not a sudden, explosive breaking of the will, but instead a quiet unfolding of the heart.
"That's what _we_ do," Lincoln replied. "We're problem solvers. And that's all we're asking you to do for us. _With_ us. Help us solve a problem. You didn't know what you were getting into, I get that."
"I knew enough," Prakoso said, shaking his head again. "I always know."
"Do you? Do you know enough about what they used your work for, Yayan?"
He shrugged.
"Do you want me to tell you the number of casualties?" Lincoln said.
Prakoso's eyes glinted, some combination of anger and fear. Whatever he thought he'd done for those people, he seemed genuinely shocked that it had caused any death at all, let alone thousands.
"It's a lot," Lincoln added. "And a lot more will follow if we don't do something soon. You can't undo it now. But you don't have to let it continue. You can help us stop it. _You_ can stop it."
Prakoso looked over at Thumper, then back to Lincoln, then down at his own hands again. Lincoln leaned forward and put his hand on the man's shoulder.
"Help us stop it."
"I would like to go home," Prakoso said. "I would like only to go home. Whatever comes after, it would be worth it to see my home."
"Then help us," Lincoln said. "Help us, and we'll get you home."
"You will not," Prakoso said, looking up. There were tears in his eyes, but he did not heed them. "You _can_ not. Your people would never allow it."
"I can't help it if you escape," Lincoln said. "And a man with your skill set... I bet once we lost track of you, we'd never be able to find you again."
"You found me once."
"We found Apsis," Lincoln said. "Their fault, not yours."
Lincoln could see the struggle in Prakoso's eyes.
"I'm going to make that happen," Lincoln said. "When you're done helping us, I'm going to get you home. I give you my word on that."
"I just wanted to solve interesting problems."
They were so close, Lincoln could feel it. But he was at a loss for which direction to go. What further promise he could make, or what appeal would resonate, and tip Prakoso over to the right side.
"Captain," Thumper said, from close behind him. "You mind if I talk with Yayan alone for a few?"
Lincoln looked at her over his shoulder. She was standing right behind him now, her fingertips resting lightly on the back of his chair. This wasn't part of the plan, but something in her look compelled him to let her take over. He nodded and stood.
"All right, sure." For a moment, he thought about adding a mild threat, making some comment about hoping she could get Prakoso to understand before NID came to take him away, but he caught himself, decided to take it a different direction. Lighten the mood, treat the moment as though Prakoso had already acquiesced. "And is there anything else you want me to do for you two?"
"You could get us some coffee," Thumper said, and then to Prakoso added, "His coffee's better than you'd think."
Lincoln didn't know what that was supposed to mean exactly, but he didn't want to press it.
"You drink coffee, Yayan?" he asked.
The man shrugged his shoulders.
"I'll see what I can scrounge up on this tub," he said, and left the compartment. Directly across the passageway was the other compartment they'd been given for their use, and the crew had been kind enough to leave behind a personal coffee brewer. Sahil and Wright were nowhere to be found, but Mike was racked out on one of the bunks. He raised his head when Lincoln entered.
"Hey, cap," he said. "Pop him yet?"
"Not sure," Lincoln answered, as he walked over to the coffee supplies. "Close, I think. Thumper's trying to close the deal right now."
"And you're doing what?"
Lincoln held up one of the disposable coffee cups.
"Sure, I'd love some," Mike said with a smile, and dropped his head back to his pillow.
Lincoln took his time, not sure exactly how long Thumper needed to do whatever it was she had in mind. Ten minutes, maybe. When he was done, he handed a cup off to Mike and crossed back over to the other compartment.
Upon entering the compartment, Lincoln knew immediately that something had changed. Outwardly the difference in Prakoso was slight; his shoulders slumped less, his eyes weren't as quick to avoid contact. But the atmosphere in the room had shifted, as if Lincoln had walked in and interrupted them sharing gossip about him. Thumper had moved her chair around even closer to Prakoso, at a ninety-degree angle to his; neither directly next to him, nor across from him. A position of mediation, or of counsel. She was leaning forward with her arms resting on her knees, but she sat back in her chair when Lincoln came in.
"You two aren't up to something in here, are you?" Lincoln asked.
Prakoso looked up at Lincoln with a neutral expression.
"Common interests," Thumper said with a shrug and a smile. Prakoso returned his eyes to his hands when she said it, but one corner of his mouth turned upward.
Lincoln handed Thumper her coffee, and then held the other cup out in front of Prakoso.
"So what'd I miss?"
"Just talking shop," Thumper said. "Nice to get a chance to chat with someone who speaks the language."
Prakoso took the coffee. "Thank you."
He took a sip, and after a moment his eyebrows went up, as if in surprise.
"Pretty good, isn't it?" Thumper said. Prakoso nodded.
"It's just coffee," Lincoln said. "It's not like I do anything special to it."
"It's probably |
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] | 106 degrees by ten am every single day, and kept on going. Fred is in his early seventies. He’s tougher than I am, but I took a look at the space he’d have to work in, thought about having a fellow in his 70s up there doing roof framing with the temperature at 110 outside and probably at least 15 degrees higher in the attic, and I shook my head. I told him the hot water wasn’t enough of a priority for me to make him go up there until it cooled down a bit.
I think that’s scheduled for December. In the meantime, I take tepid-to-cold showers in supremely hard water. I have been losing weight rather dramatically in the heat, but my hair has been gaining it back. I may have a bottle of conditioner built up in there by now.
It’s not surprising the water’s hard: it’s well water in the desert. If I live here for a few years I join a high risk group for kidney stones. Fred says the well up the road taps into an underground lake, 700 feet down. He claims the drill brought up a catfish.
This house is not particularly efficient at keeping desert invertebrates outdoors, as I found out a couple weeks back when I met one of my neighbors on my screen porch. I had the bad manners to step on him in my bare feet. I’d never been stung by a scorpion before. I don’t particularly care to repeat the experience any time soon, but all in all it wasn’t as bad as a typical bee sting. I have since stepped more lightly in the house. This is good, because the scorpion isn’t the only thing roaming my floors: just the pointiest.
There are crickets in abundance, coming un through the missing weatherstripping on the screen door, and they drown themselves in my kitchen sink with some regularity. They hang out in the sink with the roaches, long thin wild-looking cousins of the scurrilous versions found in the city. These desert roaches are inoffensive and rather sleek looking, almost like mantids. The crickets have caused me to change my ways: I had the habit of pouring out my leftover coffee in the sink, and for a couple days running I accidentally doused a black cricket, which stood there after cleaning its antennae and jittering. It occurred to me that after a week I might wake to find the cricket on my bedside table, staring at me with eyes aflame, then running pell mell back to the sink when I got up so it’d be ready for the coffee cart. I dump the coffee more carefully now.
There are some dramatic visitors, like the palo verde root borers that made a sudden appearance two weeks ago, and then just as suddenly went missing again. They are perhaps the nastiest looking insects I have ever seen, four inches long on average and built like construction equipment, olivedrab and black with segmented antennae and ferocious looking mandibles. They look positigvely Devonian, and I was relieved to find out they’re relatively affable neighbors. I felt a scratching on the top of my left foot one night, looked down. A palo verde root borer had climbed up there rather than go around. I feared a sudden movement might compel it to hold on with those mandibles, so I froze. But it just ambled on over Tarsal Pass and down the other side, minding his own business.
I know some people are bothered by bugs, and honestly I’m often one of them, but this is the first time in more than two decades I’ve lived without pets, and so far the invertebrate housemates have, with that one exception, been unintrusive. They’re actually fairly good company, though I suppose if as a newly single person I decide to have what one might delicately call a social life, some random acts of insecticide migfht become necessary.
But I think the spiders have gotten to me.
I like spiders. My last house was kind of a spider refuge. And I have some big, furry spider neighbors and housemates here, reclusive (though not recluses, thankfully) and shy, some of them rather large. The one I saw tonight was perhaps the largest non-tarantula spider I’ve ever seen, stout and round and looking as though it was wearing a berserker fur. It ran almost panicked-seeming across the kitchen floor as I walked in there tonight, cornered itself by the shelves, and I peered at it to get a better look. It was wearing something very much like a fur coat, all right, a bit asymmetrical and odd-hanging, and then I realized that the big spider was wearing a cloak of hundreds of babies. I moved back a bit and the momma spider raced out of the kitchen, around the corner into my bedroom and under my bed.
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by Chris Clarke
The hour or so before sunset is when I love this country most.
At noon, at four, the sun is deadly. Daunting. Detail on the land is lost behind relentless glare, and every speck of dust in the air catches the sunlight, further dazzles your already too-bedazzled eyes. Noon’s beauty is the beauty of endurance, the beauty of a spot of partial shade and blood-warm water from the old juice bottle you’ve carried in your pack.
But around six the heat ebbs imperceptibly, sliding slowly down from 106 degrees to a sane and comfortable 99, and something almost akin to a breeze catches you off guard. It rifles the hairs on your arms, the back of your neck. The light has changed. The sky still burns, but not quite so blindingly. The shadows of the creosote might stretch halfway across the road before you notice the change, again.
It is as though the passage of the hours has washed the air. The mountains all around you seem better-defined, more present and three-dimensional. Slanting sun casts slanted shadows. Shadows limn the hills. A bit of shade in the canyons and the mountains reveal themselves more thoroughly.
Ravens head homeward for the evening, two by two.
After a time the light changes color. White and gray clouds blush. Brown mountains bleed. A dozen miles off, or twenty or fifty, and the farther away the range the more solid the color it becomes. Last night I sat for a while beneath the west face of the Providence Mountains by Kelso, lost for the hundredth time in the infinite fractal wonder of the range’s limestone. I ran an errand last week, a quick trip to the closest ATM, in Henderson, fifty miles one way, and coming back an hour before sunset into the north end of the Ivanpah Valley I saw the Providence Mountains from seventy miles north. Their outline was as crisp as it was from Kelso, but distance had transformed the range to a solid ruddy gray. Find yourself a spot with a view of a few consecutive ranges and you may have trouble counting them. They fade stepwise and imperceptibly into the sky beyond.
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by Chris Clarke
Today I pulled a dead coyote pup off of the road.
He’d evidently lain out in the sun a little while,
but death and desert sun had not erased the sweet sly guile
there on his face, mute eyes with arid dignity unbowed
despite a cloak of flies. Across the road, funereal,
their hard-learned reticence sun-dulled, torpid, slow to react,
two golden eagles stared, accessories after the fact,
each one atop a Joshua tree, intent on bearing pall.
They did not want me there, preferred to dine without affront
there on the open road, the speeding trucks their camerieri.
I feared for them. It seemed to me that diners so unwary
would likely end as prizes in the next scavenger’s hunt.
They stirred, disturbed, as I resolved to keep them off the menu.
Clearly, the thing to do was to adjust this dinner’s venue.
He was so small. He would have fit within an eagle’s fist
and draughts of slow, dark wings could then have carried him aloft.
His face heartbreakingly familiar, clever and soft.
A plastic bag over my hand, I took him by the wrist.
I knew his paw so well, delicacy of nail and pad
with cracking calluses, resilient and deft, sweet down
disguised as fur, a silver-frosted white fading to brown
to cover it. It was that very paw that once had had
my own paws pace beside it and its kin, familiars,
until their path diverged from mine so irrevocably
cleft by the sickle-blade, that old familiar’s flesh set free
and mine adrift, stumbling in search of unnameable cures.
I’ve heard the tales of travelers who perish in the wastes
mouths choked with alkali the vultures hesitate to taste.
I understand them now. I have been aridly seduced
while walking in these dead dry desert hills, by fortune cursed,
dragging my feet. Each new rise crested scrapes the swelling thirst,
each hundred yards another coil of rope to fix the noose,
and then another |
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] | localNotification.soundName = UILocalNotificationDefaultSoundName;
localNotification.applicationIconBadgeNumber = 1;
[[UIApplication sharedApplication] scheduleLocalNotification:localNotification];
}
A:
First of all you should consider the fact that UILocalNotification class that you are using is deprecated starting from iOS 10. Since iOS 10 there is no distinction between local and remote notifications.
In UserNotifications framework (iOS 10.0+, Swift | Objective-C) one does not create instances of UNNotification like in some of the previous implementations of similar frameworks / API's by Apple. Instead, an instance of UNNotificationCenter is responsible for creating notification objects and calls delegate methods when new notifications are received and before the default UI will be displayed. See Apple's documentation for more details on the requirements for conforming UNUserNotificationCenterDelegate protocol. I often end up using AppDelegate as a class conforming to that protocol
Now back to the question. To initiate a creation of the notification from within the app first you should create a trigger (in your case you might want to use UNTimeIntervalNotificationTrigger), then create a notification request and finally add the request to the notification center singleton that can be accessed by calling UNUserNotificationCenter.current().
let content = UNMutableNotificationContent()
content.title = "Alert Fired"
Create a trigger that will determine the moment when UNUserNotificationCenter will invoke the notification
let trigger = UNTimeIntervalNotificationTrigger(timeInterval: 0, repeats: false)
Create a notification request. You only create those to invoke local notifications, since iOS is responsible for creating request objects for incoming push notifications.
let request = UNNotificationRequest(identifier: "FiveSecond", content: content, trigger: trigger)
Now we will have to add our request to the current notification center associated with our app.
let center = UNUserNotificationCenter.current()
center.add(request, withCompletionHandler: nil)
In our case the notification will be triggered immediately by the UNUserNotificationCenter.
Q:
Who exactly knew that Chancellor Palpatine was Darth Sidious?
There are only few people who know it.
I can include the following people:
Count Dooku/Darth Tyranus - I'm sure he told Dooku, because he played such a huge role in Palpatine's plans and the war, so he would always have to know what's going on. Plus by the look on his face when Palpatine told Anakin to kill him, he looked at him like he knew who he was.
Mas Amedda - I think he knew, because Palpatine would have told him so they could work together in the Galactic Senate to get whatever results Palpatine wanted, plus in an episode of The Clone Wars, Palpatine says something to him about his plan coming together.
Sly Moore - I think she had as much of a major role with Palpatine and the Galactic Senate as Mas Amedda did. During the speech of the Emperor in Revenge of the Sith, she was there.
Did Darth Maul and General Grievous know that Palpatine is Darth Sidious?
Note: the idea for this question came from http://boards.theforce.net/threads/who-exactly-knew-chancellor-palpatine-was-darth-sidious.50009052/
A:
Besides those you mentioned, a few others knew his identity.
Ahsoka Tano:
The shadow was almost certainly one of the dark side’s creatures. Ahsoka had no idea what sort of thing it might be, but whatever it was couldn’t be that powerful, because it hadn’t been able to track down Hedala. That ruled out Palpatine himself, not that the Emperor could just show up on a planet without causing a great deal of alarm. (Ahsoka)
Eneb Ray:
While it's never explicitly stated in the canon that Maul knew, it's very likely he made the connection at some point, given that he recognized the Empire as his enemy. He did know in the Legends continuity, though.
What then if- beyond contemplation- something should befall his Master? Unlike Darth Sidious, who masqueraded as Republic Senator Palpatine and debated complex issues in the Senate, Maul lacked a secret identity. With his yellow eyes and horned head a black-and-red mask of arcane sigils, it was all he could do to prowl the fringes of The Works in the dead of night without instilling fear in nearly every being whose gaze he caught. (Darth Plagueis)
Yoda, Windu and the various other Jedi who learned his identity in Revenge of the Sith, as well as Luke Skywalker.
Tarkin had his suspicions:
Tarkin may also have determined that Vader was a Sith. If so, it followed that he accepted that Sidious was Vader’s dark side Master. (Tarkin)
Grievous did not know.
3.19 lakh rats killed in 7 days? BJP leader Eknath Khadse wants a probe. (File Photo) 3.19 lakh rats killed in 7 days? BJP leader Eknath Khadse wants a probe. (File Photo)
In a startling revelation, BJP leader Eknath Khadse alleged Thursday that the company awarded a contract for pest control in the state secretariat has claimed that it killed 3,19,400 rats in seven days. The work order to a private company was given by the General Administration Department of the Maharashtra government, under Chief Minister Devendra Fadnavis.
A former minister, Khadse told the Vidhan Sabha there was something rotten which needed a thorough investigation to get to the rats playing hide and seek in government’s headquarters at Mantralaya, the state secretariat.
“A company which was given the award for killing rats has claimed it killed 3,19,400 rats within seven days in Mantralaya,” he said. Raising more questions, he said, “Can there be so many rats in Mantralaya? And would it be ever possible to execute such an exercise within seven days.”
Dismissing such statistics and claims as bizarre, he said, “The government should conduct a probe in the entire matter.”
“The government will probe the matter to ascertain the facts about the company, tender process and job.” “The government will probe the matter to ascertain the facts about the company, tender process and job.”
The Brihanmumbai Municipal Corporation has managed to kill six lakh rats in two years in the entire city of Mumbai, he said, which begs the question of where has the private company spotted so many rodents. The GAD issued the work order to the company based on a survey which allegedly said there were 3,19,400 rats in Mantralaya and the company was given six months to get rid of them all.
If these statistics are true, it means “They had to kill 45,628.57 rats a day. Now, those 0.57 must be the new born ones,” Khadse said. He also said that it must be a super-efficient company to have been able to kill 31.68 rats every half minute, evoking laughter in the state Assembly.
“The total weight of these rats which were killed would be 9,125.71 kg. It would mean one truck would be required to carry the dead rodents and get them disposed.” Strangely, he said, nobody in the Mantralaya had seen this exercise conducted.
Unwilling to let the issue go, Khadse wondered why the government did not deploy ten cats to do the job. Now, if they had set the cats loose it would have worked effectively and free of cost, he said.
In his reply to a debate on budgetary demands, Maharastra minister of state for GAD, Madan Yerawar said, “The government will probe the matter to ascertain the facts about the company, tender process and job.”
BJP MLA Charansingh Waghmare, who sought information on the alleged irregularities under RTI said, “The contract was given to a Labour Society. It was for six months. It was reduced to two months. But the company claimed the work was over within seven days. The bill book shows the work was done within the period between May 3 and May 10, 2016.”
He also said, “ There was no tendering process was followed. I have already complained this matter to Chief Minister’s Office. I have sought a probe.”
📣 The Indian Express is now on Telegram. Click here to join our channel (@indianexpress) and stay updated with the latest headlines
For all the latest India News, download Indian Express App.In addition to all of the problems Whitaker describes in the linked article—failed diagnostics, failed theories, failed “disease models,” failed treatments, making matters worse for the mentally ill, and drugging children and minors without their consent—I would further submit that our generally accepted model of the human mind itself is as deeply flawed.
Rather than starting with the idea that humans have or develop personalities that do or don’t adapt well to some ambiguous social standard, we would do better to start with the idea that humans are fundamentally interactive beings, beings that communicate.
If our interactions are good, we will be well enough. If our communications |
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] | the flatfoot?"
" _Mike_ ate every bite—but I did bake up a storm for his kids and his squad meeting. Your mother ate the last of the biscotti."
"Damn."
"But I still have a few Chocolate-Bottom Banana Bars upstairs."
"Lovin' from the oven . . ." He clapped his hands together and rubbed. "Now you're talking!"
Matt always did look forward to my home cooking. His new wife, Bree—disdainer-in-chief of _Trend_ magazine—was many things, but a baker of banana bars wasn't one of them.
"Sit tight," I said.
Unfortunately, he didn't.
After climbing the stairs to my duplex apartment and venturing into the kitchen, I heard Matt's familiar footsteps. Turning, I found my ex-husband leaning against the doorjamb, hands in the pockets of his tight black jeans.
"What are you doing up here?"
He shrugged, a bad-boy look on his black-bearded face.
_"Matt?"_
"It's warmer up here."
"No, it's not. Go back down to the shop."
"Why?"
"Because you don't _live_ up here. Not anymore."
Matt's slow-spreading smile was beyond smug.
"What's so funny?"
"The reason you don't want me up here," he said. "It's obvious: you don't trust yourself around me."
"Oh, please!"
He crossed his arms. "Prove it."
"You're a child sometimes, you know that?" I expelled a frustrated breath. "Fine! Sit down, then."
"Not here. We'll be more comfortable in the parlor. I'll start a fire for you there . . ." He caught my eye as he peeled off his jacket. "Unless you'd like one in the bedroom."
"Don't get cute or I'll put you on the sidewalk—by way of a third-floor window."
"Just checking."
Ten minutes later, I was sitting by a roaring blaze again, this time on the rosewood-framed sofa in the duplex's well-appointed salon.
Matt's mother had decorated the place herself, collecting and placing gorgeous pieces over many decades. The main room—with its carved rosewood and silk sofa and chairs, jewel-toned Persian prayer rug, cream-marble fireplace, and French doors opening to a narrow, wrought-iron balcony of flower boxes—felt more like something you'd find in a Paris arrondissement __ than a New York walk-up.
As a girl who grew up in a Pennsylvania factory town, I continued to feel grateful and blessed for the privilege of sitting here amidst this Old World elegance, sipping my hot, fresh cup of Fireside Blend. Matt, who had grown up in a sophisticated world of beauty and culture only to become an extreme sports nut and cocaine addict, was acting as he usually did in his mother's apartment—aloof to civilization.
Barely chewing, he stuffed three of my Chocolate-Bottom Banana Bars into his mouth inside of two minutes.
"Didn't you have dinner?"
"Many hours ago," he garbled mid-chew and brushed crumbs from a black, cashmere V-neck just tight enough to show off his sculpted pecs. "Bree and I went to her favorite sushi bar before she hopped a flight to LA. But, I'm sorry to say . . . no matter what Bree treats me to, it seems I'm never completely satisfied . . ."
He threw me a suggestive smile. I rolled my eyes.
Matt and Bree had an open marriage, and when the cat was away, Matt loved to play. But there was no playing around here, which I'd made clear enough _multiple_ times.
"Enjoy the baked goods," I told him, "because they are the _only_ goodies you'll get from me tonight."
Unfortunately, the thickest muscle in Matt's body was in his head. All he did was smile wider.
"Okay, talk already," I demanded. "What did your mother want you to discuss with me?"
"The artwork." The swipe of a napkin wiped his smile, too, and his mood shifted. "I know it's not a happy conversation, Clare, but you have to make the decision."
"What decision? I don't know what you're talking about."
"What do you mean, 'you don't know'—" He stopped abruptly, studied my perplexed face, and cursed (in several languages). "She didn't tell you!"
"Tell me what?!"
"I can't believe she dumped this on me," he muttered.
"Matt, explain!"
He closed his eyes and took a breath. "The insurance adjuster called Mother this afternoon. The news wasn't good, Clare . . ."
"How bad is it?"
"Bad . . ."
He went over the numbers with me, and my heart sank.
"Our insurance company contacted Thorner's insurers. They're hiding behind their legal skirts. They refuse to pay a cent until the legal issues surrounding the case are resolved."
"You mean the bomber needs to be caught?"
"And convicted. Then they can go after the guilty party in civil court to claim damages."
"But even if they arrested someone tonight, the trial wouldn't come up for at least a year!"
"I know. Our insurance company is prepared to cut us a check and wait for Thorner's insurers to reimburse them, but it's nowhere near what we need . . ."
Because our coffeehouse was located in the Village historic district, exterior restoration would have to comply with strict codes. We'd need to hire construction companies with specific expertise, which meant repairs wouldn't be cheap. The estimate was astronomical.
"Mother refuses to mortgage the place or sell any of the furniture, but she is going to have a fire sale with her jewelry collection—"
"So that's why she only wore one piece tonight?"
Matt nodded. "The rest is being appraised. In a few days, she'll select which pieces to sell—"
"That's going to break her heart!"
"And she wants you to number the pieces of artwork from the coffeehouse and the duplex. Give her a list of items you're willing to part with, in descending order. Otto will appraise them and you can make the final decision."
"Decision on what?" I gawked in horror as it hit me. "On which ones to _sell_?"
"Or auction, yes. We'll only sell off what we have to until we reach the amount we need."
"But, Matt—it's a hundred years of Village Blend history!"
"I know."
"I can't believe this is happening to us . . ."
"Believe it."
I couldn't sit still any longer. On my feet, I began to pace. "Your mother should be the one to choose which pieces."
"She wants you to do it, Clare."
"But she's the one who has the most personal attachment to it all! Oh, Matt, imagine her memories!"
"That's why she wants you to do it. It's too painful for her, and Mother said . . ." His voice trailed off.
"What?" I whispered.
Matt's expression looked sadder than I'd seen it in a long time. "Mother said you'll be the one living with the remaining artwork for the next thirty years, not her—and that's why the choice should be yours."
His voice was even, but his eyes were damp. The words made me think of losing her, too, which made my own eyes well.
"Aren't you going to help me choose?" I asked, my voice barely there.
"Clare . . . I'm no art expert. I spent most of my adult years traveling the globe. You're the one who went to art school. You and my mother—that love was something you two shared from the beginning." The firelight flickered, casting shadows of regret across Matt's olive complexion. "It was always your thing, not mine . . ."
He rose. "So you'll let me know? Give me the list sometime tomorrow, then?"
I moved to the door with him, swiped the moisture off my cheeks. His strong arms reached for me; I stepped back.
"Sorry," he said, slipping into his bomber. "Old habits die hard . . ."
The words made something inside me lurch. More than anything, I wanted to fling my arms around the father of my daughter and cry my eyes out, but I held myself in shaky check.
Matt would be happy to give me comfort with his hard body, and I would gladly take it—possibly too far. I'd never admit it, but he was right. Alone and hurting, seeing that tenderness in his liquid-brown gaze, feeling that desire to console me in his soft touch, I didn't trust myself.
"Good night, Matt," I said stiffly. "I'll see you tomorrow."
"Chin up, okay?" He cleared his throat. "I'll bring that generator from |
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] | . The trelliswork around the door supports a spindly climber, Mummy holds little Ian – who's one and a half, maybe two? – like a misshapen rugby ball that someone has passed her; and which she wishes she could immediately pass-kick forward, beyond the touchline of maturity. But in place of Daddy, there's just this painted-in glob, this fuzzy outline. Somebody has got at my eidetic memory and retouched it. They've removed Daddy the way that the Stalinist propagandists painted out Trotsky. When Lenin arrived at the Finland Station and mounted the crude, hastily erected rostrum, Lev Davidovich was there. But as Vladimir ranted, Lev, like some Cheshire Cat, began to fade, the planks started to show through his brow; eventually all that was left was a stain.
It's the same for the rest of my childhood. At all the Party Congresses that we know Daddy to have attended, he has been negated, erased, excised from the picture. Whether propped against the bonnet of the family Mark 1 Cortina (same birthdate as my own), or sprawled on the sheep-cropped and sheep-bedizened grass around the Chantry, it's the same. Only Mummy and Ian, or Mummy, Ian and maternal relatives – plus this Daddy-absence; this Daddy-vacuity; this Daddy-erasure.
I am a big man, like my father. I have his mousy hair and low forehead. I couldn't possibly be said to be ugly, for my features, in themselves, are shapely enough. The cratered dimple in my chin lines up precisely with the scoop out of my top lip and the narrow bridge of my long nose. No, my problem is the same as Daddy's – my features are marooned, set too far in to the middle of my wide face. Furthermore, the way everything falls away at the edges of my face is rather unpleasant. It gives a sodden, lippy impression, like the margin of a peat bog.
I have my father's figure as well. Sometimes, when I inadvertently catch sight of myself getting out of the bath, I freeze, startled, and think: Who let that Russian peasant woman in here? But it's only me, because – you see – my hips are wider than my shoulders and my solid legs look as if babies could be squeezed out from their confluence as easily as grapefruit pips. I'm built like a babushka.
And another thing, another point of resemblance. When I was a child I was reasonably well co-ordinated, but as I have grown up my sense of body has become both cloudy and diffuse. My fingers and toes are now distant provinces, Datias and Hibernias, cut off for years at a time from the Imperial nervous system. Without The Fat Controller's instruction in the blacker arts of physicality I would undoubtedly have become as hamfisted as Dad was. I certainly look as if I ought to be.
If I mention my father at the outset, it is because I want to get his having been out of the way, out of the way. After all nurture has trumped nature a thousandfold as far as my being is concerned. And if I were to see Dad now (I have no idea if he is alive or dead), I should feel compelled to dispose of him. I have no doubt about that. His presence would be an affront to my body; so, for it, there would be the rare delight of extinguishing an imperfect and distressed version of itself, a prototype, a maquette. I should enjoy the bludgeoning of my own features, the pulverising of my own thick bones and the slashing to ribbons of the nauseating congruence of our flesh – more, perhaps, than I've enjoyed any of my other little outrages.
Why, oh why, oh whyeeee! Why did Daddy abandon me like that? That's the $64,000 question, that's the Golden Shot. Why didn't he care for me, love me? He must – I am forced to conclude – have been a weakling, an emotional eunuch. That much is certain. He stepped aside and indifferently flicked a wet blanket at the raging bull of paternity. For that I can never forgive him.
When I was at university, The Fat Controller saw fit to supplement that version of my father's history that my mother had retailed when I was a child. It is characteristic of The Fat Controller that he should have extemporised in this fashion, dropping bombshells of feeling as casually as crumbs. We were sitting in a café and I recall that he was dunking a doughnut as he spoke, paying no mind to the tea slopping on his cuff, or the granular snowfall on his jacket lapels.
'Your father – Harrumph! A contemptible Essene and no mistakin' – I knew him well, of course.'
'You've never said so before.'
'Well, why should I? I've had no cause to. But now you are about to embark on a career it is only fair that you should know a little more about him. I dare say that your mother always spoke of him as a "brilliant man".'
'She did.'
'Quite so, quite so. Did ye believe her?'
'Well, not entirely, I never saw any evidence of it. While he was at home he never left the sun porch. He sat there all day reading the newspapers. Not even the nationals – he didn't seem to have the gumption to deal with anything much but the local advertiser.'
'And then he went on his pilgrimage, by bus, I believe. He did at least understand this much, that the timetable expresses a set of mutable, quasi-astrological relations, the coming and going of ferrous bodies —'
'Aren't you getting off the point?'
'What point!' he exploded – he could never abide interruption. 'Don't be a booby, sir, you know I will not have a booby for an interlocutor!'
'I'm sorry.'
'Sorry isn't good enough – never is.'
We sat in silence for a while. The Fat Controller dunked. I looked on as the customers in an adjacent emporium crammed themselves into unsuitable denims. Eventually The Fat Controller spoke. 'You knew that he was a businessman, of course?'
'Yes, Mum told me that. I assumed that it was something insignificant, perhaps wholesale dry goods.'
'Oh no, you've got it wrong there, boy. You probably can't remember but the furniture your mother had in the bungalow when you were a child came from the old St John's Wood house. It was really quite good, perfectly substantial. It dated from the time when you were very small and your father ran Wharton Marketing.'
'He had his own company then?'
'Absolutely. Your father was one of the most successful marketeers in sixties' London. He had a real flair for it. Knew just how to launch a product, what activities were required, sales promotion or advertising. He had a nice line in statistical interpretation as well.'
'What happened, why did the business fail?'
'Well, people at the time said that it was mismanagement. They pointed to several large accounts that your father had either lost or failed to win, but that was a facile explanation. The truth was that he got bored.'
'Bored?'
'Oh yes – yes indeed. I knew him, as I say. Naturally, for I knew everyone of consequence. I had even done business with him on a number of occasions. I actually went to see him not long before the final collapse. The receivers were champing at the bit, I passed a man with a writ in the vestibule. Your father told me himself: "I just can't be buggered, Samuel," that's what he said, "I can't even summon up the energy to sign a cheque. I can't engage any more." That was the whole explanation, he was subject to a kind of fatal ennui. There was no other reason why the business should have gone down at all.'
So my father had retreated into his apathy and my mother moved the family to Saltdean. That much I had known already, and it was because of this that my conscious life began on a cliff. I say a cliff but really the site was more like a monstrous divot, kicked out from some golf course of the gods. On the divot sat the interleaved environs of the twin resorts of Saltdean and Peacehaven. Behind them was the ridge of the South Downs. Their rounded summits had a humanoid aspect, as if they were the grassed-over skulls of long-buried giants. In the lee of the Downs, between Saltdean and Rottingdean, were two contradictory edifices. One was a sprawling red-brick manse, the girls' public school, Roedean. The other was a hideous Modernist joke, the prefiguration of ten thousand bypass-bound corporate compounds, the blind people's home, St Dunstan's. Both establishments were to play a part in my upbringing, a pivotal part.
Saltdean and Peacehaven, taken together what did they imply? Well – for the property speculators that built them – that the less well-heeled could |
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] | "bc_pipe");
}
@Override
public String preferredName() {
return "bc_pipe";
}
@Override
public int priority() {
return -10;
}
@Callback(doc = "function():string -- Returns the type of the pipe.")
public Object[] getPipeType(final Context context, final Arguments args) {
try {
return new Object[]{tileEntity.getPipeType().name()};
} catch (Throwable ignored) {
}
return new Object[]{null, "none"};
}
@Callback(doc = "function(side:number):boolean -- Returns whether the pipe is connected to something on the specified side.")
public Object[] isPipeConnected(final Context context, final Arguments args) {
try {
return new Object[]{tileEntity.isPipeConnected(ForgeDirection.getOrientation(args.checkInteger(0)))};
} catch (Throwable ignored) {
}
return new Object[]{false};
}
@Callback(doc = "function(color:string):boolean -- Returns whether the pipe is wired with the given color.")
public Object[] isWired(final Context context, final Arguments args) {
try {
return new Object[]{tileEntity.getPipe().isWired(PipeWire.valueOf(args.checkString(0)))};
} catch (Throwable ignored) {
}
return new Object[]{false};
}
@Callback(doc = "function(color:string):boolean -- Returns whether the wired with the given color is active.")
public Object[] isWireActive(final Context context, final Arguments args) {
try {
return new Object[]{tileEntity.getPipe().isWireActive(PipeWire.valueOf(args.checkString(0)))};
} catch (Throwable ignored) {
}
return new Object[]{false};
}
@Callback(doc = "function(side:number):boolean -- Returns whether the pipe has a gate on the specified side.")
public Object[] hasGate(final Context context, final Arguments args) {
try {
return new Object[]{tileEntity.getPipe().hasGate(ForgeDirection.getOrientation(args.checkInteger(0)))};
} catch (Throwable ignored) {
}
return new Object[]{false};
}
}
}
books.google.com - Hammer (forensic nursing, Quinnipiac University) et al. present a textbook in the new field of forensic nursing, which has come to the forefront in the wake of rising violence. Nurses, crime and forensics experts, and scholars from the US offer 27 chapters on theoretical foundations, the epidemiology...https://books.google.com/books/about/Forensic_Nursing.html?id=_FVrAAAAMAAJ&utm_source=gb-gplus-shareForensic Nursing
Forensic Nursing: A Handbook for Practice
Hammer (forensic nursing, Quinnipiac University) et al. present a textbook in the new field of forensic nursing, which has come to the forefront in the wake of rising violence. Nurses, crime and forensics experts, and scholars from the US offer 27 chapters on theoretical foundations, the epidemiology of violence, collaboration within disciplines, eQ:
Responsive design not working on heroku deployed rails app?
I recently deployed a rails app onto: http://secret-brook-8909.herokuapp.com/
I intended it to look on the iphone 4s to look like it would using: http://responsive.victorcoulon.fr/
If you look at the stylesheet of my rails app you will actually see that i hardcoded all the widths of the containers to be 320px. But when I open it on my browser on my iphone it looks like its being opened on a larger resolution screen. Additionally, on the iPhone if you click the profile button, the button doesn't look the same as it does on a normal browser.
What can I do to fix these issues?
A:
you need to add a viewport declaration on the head of the document
<meta name="viewport" content="width=device-width, initial-scale=1.0">
Q:
Custom alignment of columns in align environment
I need to typeset two columns of equations, each row typeset with an equation number to the right as with an ordinary equation. The first column must be centered, and the second column must be left-aligned. There will be many rows, so it must automatically break at a page break as appropriate.
There are plenty of related questions, but I can't find any existing solutions that will let me do exactly what I want. (It's a real pain the align environment can't take optional column alignment specifiers.)
A:
Making align break across pages is simple: add \allowdisplaybreaks[1] to your preamble.
And since your first column is text, it's also trivial to center it within align: just wrap it in a \makebox larger than all the images (which centers its contents) and use align as normal.
\documentclass{article}
\usepackage{amsmath}
\allowdisplaybreaks[1]
\newcommand{\centerdia}[1]{\makebox[2in]{\includegraphics{#1}}}
\begin{document}
\begin{align}
\centerdia{dia1} & c=20x^2+5x-10+\frac{x^3-4x^2+500x-f(240)}{50} \\
\centerdia{dia2} & \mu=10*\epsilon\\
\centerdia{dia3} & \mu=10*\epsilon
\end{align}
\end{document}
A:
Use a modified version of align; change 2\tabcolsep into the separation you prefer.
\documentclass{article}
\usepackage{amsmath,environ}
\makeatletter
\NewEnviron{specialalign}
{\def\align@preamble{%
&\hfil
\strut@
\setboxz@h{\@lign$\m@th\displaystyle{####}$}%
\ifmeasuring@\savefieldlength@\fi
\set@field
\hfil
\tabskip2\tabcolsep
&\setboxz@h{\@lign$\m@th\displaystyle{{}####}$}%
\ifmeasuring@\savefieldlength@\fi
\set@field
\hfil
\tabskip\alignsep@
}%
\begin{align}\BODY\end{align}}
\makeatother
\begin{document}
\begin{specialalign}
x & a=b \\
yyy & c=d+e+f \\
zzzzzz & 1\ne0
\end{specialalign}
\end{document}
76 B.R. 1001 (1987)
In re Louis FLEET, Debtor.
Louis FLEET, Sarah Morrison, Philadelphia Unemployment Project on behalf of themselves and all others similarly situated, Plaintiffs,
v.
UNITED STATES CONSUMER COUNCIL, INC., Jack Rhode, Betty Rosi, Deborah Tavares, Defendants.
Bankruptcy No. 81-04969K, Adv. No. 83-0880K.
United States Bankruptcy Court, E.D. Pennsylvania.
August 18, 1987.
*1002 *1003 Wayne Powell, Barry J. Hockfield, Cherry Hill, N.J., for defendants.
Henry J. Sommer, Gary Klein, Community Legal Services, Philadelphia, Pa., for plaintiffs.
Edward Sparkman, Philadelphia, Pa., Trustee.
OPINION
DAVID A. SCHOLL, Bankruptcy Judge.
A. INTRODUCTION
Presently before us in this long-outstanding proceeding is a Motion for Class Certification by the Plaintiffs. We reject the Defendants' principal argument that the Motion should be denied because it was not filed until the case was over four years old, holding that any unfair prejudice arising from the Plaintiffs' delay is, for the most part, cured by our further holding that the default entered against the Defendants does not extend in its effect to unnamed class members. We also reject the Defendants' arguments that the elements of commonality or adequacy of representation are lacking and find all of the prerequisites to maintain a class action set forth in Federal Rule of Civil Procedure (hereinafter referred to as "F.R.Civ.P.") 23(a) present.
However, we also hold that the fact that the Defendants are no longer doing business renders the only practical relief for unnamed class members to be strictly monetary relief. Therefore, we conclude that the matter may be maintained as a class action pursuant to F.R.Civ.P. 23(b)(3) only. Since the Plaintiffs have not addressed the issues of provision and cost of notice to unnamed class members, pursuant to F.R. Civ.P. 23(c)(2), or their proposed methodology for handling these claims, we shall only grant the Plaintiffs' Motion conditionally |
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] | que tu me dis toujours tout ce que tu penses, et que près de moi quand je te le dis, tu as raison de ne prendre ombrage de rien.
Je puis naturellement me tromper. Tu me diras.
Aucune nouvelle de Gaffé, d'ailleurs, ni de l'acheteur possible du Derain (ce dernier ne répondra que dans huit jours).
Voilà.
Et je ne t'ai rien dit de toi. Mais c'est presque assez, n'est-ce pas, que je t'aie parlé ainsi. Toi seule, à ta place, peux m'entendre.
Vous savez que je ne vois clair qu'en vous regardant
Je ne suis pas très intelligent
pas très bon
pas très fort
et je ne suis même grand-chose que le matin, en m'éveillant, quand je tiens vos deux petites mains dans la mienne.
André
_Par exprès_
_Enveloppe : Madame André Breton, Chez Madame Georges Lévy,_
_12, quai Saint-Nicolas, Strasbourg (Bas-Rhin)_
_Cachet de la poste : 9-11-26_
✩
## _Carte postale_
D'arche en arche, du plus loin au plus près, je pense à ma petite Simone bien-aimée.
André
_Carte postale : Blackfriars Bridge, London_
_Adressée à Madame André Breton,_
_42 rue Fontaine, Paris, France_
_Cachet de la poste : 24-5-27_
✩
## _Sur papier à en-tête de_
LA RÉVOLUTION SURRÉALISTE
_Paris, le 29 juillet 1927_
Mon petit chéri, je suis las, très las. Tu sais, tu m'accorderas que ma pauvre vie d'imbécile ou de voyou se passe à ne pas m'attendre à presque tout ce qui m'arrive, à m'attendre aussi à ce qui n'arrive pas. Je ne m'attendais à rien moins qu'à ce départ, enfantillage d'abord, comment ne le considérerais-je pas ainsi ?, grave et _dur_ rappel à l'ordre ensuite. Toi partir ? Je ne pleure pas non plus. Je suis calme. Toi partir ! Mon cher petit, de quoi s'agit-il donc ? Que fuis-tu ? Comme je l'avais vaguement senti hier au téléphone, il a donc suffi d'un jour ou deux pour que tu t'éloignes de toute cette distance qui avait été supprimée une fois pour toutes, je croyais ?
Impossible, avec la meilleure volonté, de prendre au sérieux le prétexte que tu me donnes : ces propos tenus, en pensant à je ne sais quoi mais pour sûr, pas à nous. Insister sur ce point m'écœurerait. _Pas à nous_ : je le jure. À toi ? Comment même as-tu pu l'entendre ainsi ? Il faudrait que je sois devenu une belle brute, tout de même.
C'est ma faute, d'ailleurs. À quoi pensais-je ce soir-là ? Quel mauvais esprit m'animait ? Je meublais sans doute à grands frais une conversation qui me paraissait languir, comme toujours, je m'ennuie tant, je voudrais que les gens aient des langues de feu. Mettons que je sifflais comme une sale vipère que je suis parfois, oui, quand telle ou telle chose m'a trop dégoûté.
J'étais très malheureux et voilà tout. De là à te faire de la peine, à toi si noble et même ce que je sais de plus noble ( _naturellement_ ) et de plus pur, et de plus compréhensive aussi, ma chère petite Simone – mais non je ne faisais pas exprès ce n'est pas vrai. Je suis quelquefois _malheureux_ avec une effroyable conscience de ce malheur.
Mais c'est déjà trop revenir sur ces propos misérables, idiots et creux du reste si tu veux bien y songer, tout à fait indignes de mon intelligence au moins. Simone : de mon intelligence.
Le mal est peut-être plus grand. Tels qu'ils étaient ces propos, ils sont venus à l'appui d'une idée que tu te formais depuis déjà longtemps : à savoir sans doute qu'un péril qui n'est pas négligeable continuait à planer au-dessus de moi, de moi tel que tu me vois, que tu me connais... L'immense générosité dont, en l'occurrence, tu as toujours fait preuve ne m'échappe pas, tu sais. Ce n'est pas beaucoup dans les moyens humains, je me le dis depuis longtemps et chaque jour. Tout à coup tu ne t'en sens plus capable, – pardon, ma chère petite enfant.
Il faut absolument qu'ici je parle un peu de moi. J'ai beaucoup de peine à le faire. Il faut que je me force. Lassitude, confusion, découragement tu ne peux savoir tout ce qui s'y oppose. Mais je te le dois mille fois.
... _De ce côté_ si étrange, tu sais presque tout ce qui le fait si étrange, pour moi si terriblement pathétique, oui : il est ainsi. Je ne t'ai jamais rien caché. Je ne suis absolument pas guéri. Si « guérir » il y a. Pardon pour les mots ignobles. Tout ce qu'il y a de bouleversant pour moi à regarder _de ce côté_ existe toujours, et n'a pas changé. Je voudrais dire le contraire que je ne le pourrais pas. Je suis toujours hanté. « L'amour-folie » dis-tu : ce n'est pas sûr. Le mystère simple, à portée de la main. Rien qui différencie cela du trouble que causaient par exemple les « sommeils ». C'est un peu plus fort, et voilà tout. Je ne suis pas M. Maurice de Fleury, je ne crois pas et c'est peut-être mon seul tort, je ne crois pas à la nécessité de me soigner. Il se peut, je l'ai déjà dit et j'en ai peur, que ce ne soit pas, du reste, l'amour. C'est, au moins pour une si grande part, le résultat d'une culture infiniment particulière, tu le sais, de la _déception_. Une véritable perversion du goût en a été chez moi la conséquence. Rien d'absolument électif, peut-être, ne m'attire vers Lise (enfin je ne sais pas) mais c'est comme si j'avais été en même temps qu'elle, quoique tout différemment, victime d'un accident jadis. Ce n'est pas cela. En toute loyauté je ne crois pas que je devrais la fuir comme toi si simplement tu me fuis. C'est comme si l'on allait se cacher la tête dans les feuilles pour ne plus penser, pour ne plus chérir, pour faire disparaître. On ne le doit pas. Tout me dit qu'on ne le doit pas.
_Logo, réalisé par Georges Malkine, qui sera repris,
plus tard, par la Galerie surréaliste._
Tout ce qu'il y a à attendre _de ce côté_ me paraît être (tu sais ce qu'il m'en coûte de parler ainsi, à bas le positivisme abject, le matérialisme infâme de ce que je vais écrire mais tu veux, n'est-ce pas, que je l'écrive), me paraît être _la résolution fatale_ d'un état de choses qui, j'en conviens, a duré mais aussi s'est modifié en durant et qui, par suite, selon moi, fera place un jour assez prochain à un autre état de ch |
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<artifactId>zuihou-authority-entity</artifactId>
<name>${project.artifactId}</name>
<description>权限服务实体模块</description>
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<groupId>com.github.zuihou</groupId>
<artifactId>zuihou-common</artifactId>
<version>${zuihou-project.version}</version>
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<!-- databases 只有权限服务需要引用， 其他服务放在server模块 -->
<dependency>
<groupId>com.github.zuihou</groupId>
<artifactId>zuihou-databases</artifactId>
<optional>true</optional>
<scope>compile</scope>
</dependency>
<dependency>
<groupId>com.github.zuihou</groupId>
<artifactId>zuihou-injection-starter</artifactId>
</dependency>
<dependency>
<groupId>com.baomidou</groupId>
<artifactId>mybatis-plus-annotation</artifactId>
</dependency>
<dependency>
<groupId>cn.afterturn</groupId>
<artifactId>easypoi-annotation</artifactId>
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Appropriate application of information from biodiversity databases is critical when investigating species distributions and diversity: a comment on Dallas et al. ().
Using data from biodiversity informatics resources, Dallas et al. (Ecol. Lett., 20, 2017, 1526-1533) suggested limited relationships between climate and local abundance among several taxonomic groups. Investigation of a subset of these data suggests that their results may be misleading due to inappropriate application of the biodiversity data.Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Folinic acid (leucovorin, [LV]) can potentiate the growth inhibitory effects of fluorouracil (5-FU) in vitro and in vivo. LV is a precursor for 5,10-methylene-tetrahydrofolate (CH2-THF). Sufficient levels of CH2-THF enhance the inhibition of the enzyme thymidylate synthase by the 5-FU metabolite FdUMP. This study describes the effects of 5-FU and LV in two murine (C26-10, C38-1) and two human (WiDr, HT-29) colon carcinoma cell lines and in two murine tumors (Colon 26 and Colon 38). In vitro, only C38-1 was more sensitive for the combination of LV/5-FU compared with 5-FU alone. This effect was not dose or schedule dependent. l-LV, a purified stereo-isomere of LV, is thought to be the biological active form. Tests with this compound in vitro did not show a better effect than the mixture of d- and l-LV. In vivo, dl-LV could potentiate 5-FU antitumor effect in two murine colon tumors (Colon 26, Colon 38). This effect was clearly schedule dependent. dl-LV administered 1 hour before and together with 5-FU was much better than only simultaneous or posttreatment, but there was no dose dependency, while like in vitro l-LV effect was comparable to dl-LV. TdR was used to study the role of TS inhibition in the growth inhibitory effect of 5-FU with and without LV. TdR can reverse growth inhibition caused by TS inhibition due to 5-FU. In vitro, a partial reversal of growth inhibition of 5-FU and 5-FU/LV was observed, but in vivo there was no reversal. In vivo, TdR combinations led to high toxicity. Measurements of TS amounts in cells and tumors showed that those of human origin had much lower TS than the murine. C38-1 and Colon 38 with low TS were more sensitive to 5-FU than Colon 26 with higher TS amounts. TS inhibition was studied in the two murine colon tumors at several time points after weekly 5-FU or LV and 5-FU administration. LV did not increase the extent or retention of TS inhibition due to 5-FU during the first week. After three courses of treatment a fourfold increase of TS levels was seen in Colon 26 after 5-FU therapy. This resulted in a less effective TS inhibition after this treatment. Tumors treated with 5-FU and LV also showed an increase of TS, but to a lower extent, while the effect on TS inhibition remained the same.(ABSTRACT TRUNCATED AT 400 WORDS)Here comes a new Episode in the "Learning English Is Fun™" Alphabet Learning Series for Preschool Children by ChuChu TV
DEF Songs Compilation…
Here comes a new Episode in the "Learning English Is Fun™" Alphabet Learning Series for Preschool Children by ChuChu TV
DEF Songs Compilation
Letter D Song - 01:23
Letter E Song - 04:33
Letter F Song - 08:29
In this episode, ChuChu & Friends will teach your little ones about the alphabets D,E,F by travelling to the alphabet world in their toy train. Make your kids enjoy and learn with ChuChu TV. Please like and share this video. Thank You!
===============================================
Video: Copyright 2017 ChuChu TV® Studios
Music and Lyrics: Copyright 2017 ChuChu TV® Studios
ChuChu TV ®, Cutians ®, all the characters and logos used
are the registered trademarks of ChuChu TV Studios
===============================================
The NEW Numbers Song | Learn To Count from 1 to 10 | Number Rhymes For Children | ChuChu TV for Kids
00:07 The New Numbers Song
02:23 Mont…
The NEW Numbers Song | Learn To Count from 1 to 10 | Number Rhymes For Children | ChuChu TV for Kids
00:07 The New Numbers Song
02:23 Months of the Year Song
06:14 The Taste Song
07:53 Pineapple Song
09:44 Snap Snap Snap Actions Song
11:42 The Grow Grow Song
13:25 Going To the Forest
21:32 Three Little Kittens Went To The Theme Park – Cutians
24:32 Three Little Kittens Went To The Fair – Cutians
27:31 Three Little Kittens Went To The Beach – Cutians
30:33 Three Little Kittens Went Out To Eat – Cutians
33:00 Three Little Kittens Played Games at Rio – Cutians
Click here to Subscribe to SetIndia Channel : https://www.youtube.com/user/setindia?sub_confirmation=1
Click to watch all the episodes of Crime …
Click here to Subscribe to SetIndia Channel : https://www.youtube.com/user/setindia?sub_confirmation=1
Click to watch all the episodes of Crime Patrol Dial 100 - https://www.youtube.com/playlist?list=PLzufeTFnhupzBi22rTZgQbnRMWVCrUEvP
Episode 601:
--------------------
The occupants of a working women's hostel complain about a man entering their rooms when they are asleep. The hostel warden assures them that she will take action against the culprit and soon assembles all the male staff in the institution. The warden warns the staff that her eyes will now be on all of them. A few days later, one of the complainants, Pooja Agarwal, is found murdered in the restroom of the hostel. Meanwhile, Rajeev the hostel caretaker is found missing and the police go on Rajeev's trail. Is Rajeev the real culprit? Find out!
Crime Patrol Dial 100:
-----------------------------------
Crimes that tell us, we need to be careful, we need to be watchful. Crimes that tell us lives could have been saved.Every crime we hear of, either warns us to be careful or scares us, it could happen to us. Every crime ignites a feeling, 'It should not have happened'.Would knowing the 'Why' behind a crime, help in stopping a crime from happening?'I don’t like the way he looks at me', 'I don’t like the way he/she is behaving', 'I think he/she is out of his/her mind', 'I think he/she has gone crazy'. That gaze, that quirky smile, that persistent stare which unnerves. It is difficult to understand the intentions but the hints are there.In a house a husband and wife argue, fight. A vessel comes flying, a glass breaks. Husband is angry and the wife is upset. That hatred, that ego. The distance that keeps growing. It is difficult to comprehend the |
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] | uliformi subcylindrica v. leviter infundibuliformia, costis 2 prominentibus, peristomio operculum versus acuto v. acuminato, expanso, 8-35 mm lato, costis 1/2-1 mm distantibus, dentibus c. tam longis quam latis ; operculo rotundato-cordato, facie inferiore plano v. plica subcarinato ; inflorescentia racemus longus pedicellis inferioribus c. 20 mm longis omnibus 2-floris ; indumentum in partibus vegetativis subnullum, in inflorescentiis densum adpressum, e pilis stellatis compositum.
References
Further reading
Mansur, M. 2001. In: Prosiding Seminar Hari Cinta Puspa dan Satwa Nasional. Lembaga Ilmu Pengetahuan Indonesia, Bogor. pp. 244–253.
Marwinski, D. 2014. Eine Expedition nach West-Papua oder auf den Spuren von Nepenthes paniculata. Das Taublatt 78: 11–44.
Meimberg, H., A. Wistuba, P. Dittrich & G. Heubl 2001. Molecular phylogeny of Nepenthaceae based on cladistic analysis of plastid trnK intron sequence data. Plant Biology 3(2): 164–175.
Meimberg, H. 2002. Ph.D. thesis, Ludwig Maximilian University of Munich, Munich.
Meimberg, H. & G. Heubl 2006. Introduction of a nuclear marker for phylogenetic analysis of Nepenthaceae. Plant Biology 8(6): 831–840.
Renner, T. & C.D. Specht 2011. A sticky situation: assessing adaptations for plant carnivory in the Caryophyllales by means of stochastic character mapping. International Journal of Plant Sciences 172(7): 889–901.
External links
Photographs of N. insignis
insignis
Category:Carnivorous plants of Asia
Category:Flora of Western New Guinea
Category:Endemic flora of New Guinea
Category:Threatened flora of Asia
Category:Plants described in 1928
Category:Vulnerable plantsGenetic role of rat macrophage cytotoxicity against tumor.
Macrophages from the Lewis (Le) rat strain are significantly more cytotoxic to a Moloney sarcoma tumor both in vivo and in vitro, than are macrophages from the Brown Norway (BN) strain. Activity of macrophages from (Le x BN)F1 rats that are histocompatible with the Moloney sarcoma tumor is directed toward tumor and/or virus-associated antigens and is expressed as a dominant genetic trait. Experiments with backcross rats suggest that the genetic factors are unrelated to the major histocompatibility locus (AgB) of the rats. BN microphages, although not active against tumor and/or viral antigens, can become cytotoxic to cells displaying Le alloantigens.Cyclea elegans
Cyclea elegans is a species of flowering plants in the family Menispermaceae. It is found in Sumatra, Malaya, Borneo. An isotype is kept at Kew Gardens Herbarium. It was collected on Mount Kinabalu Dallas.
References
Other references
Ridl. in Fl. Mal. Pen. 1922: 115
Burk. & Hend. Gard. Bull. S. S. 1925: 344
Yamamota J. Soc. Trop. Agric. 1944: 145
Yamamoto J. Soc. Trop. Agric. 1944: 145
Forman Kew Bull. 1960: 71
Heine Fedde, Rep. 54. 1951: 227
Diels Pfl. R. 1910: 311
Airy Shaw Kew Bull. 1940: 538
External links
Cyclea elegans at Flora Malesiana
Category:Plants described in 1889
Category:Flora of Borneo
Category:Flora of Malaya
Category:Flora of Sumatra
elegansQ:
React, best way to deal with fetching when navigating between routes containing same component
Basically, I would like to fetch the latest data every time user navigates to different tab. For example, I have summary page and details page for customers, which both includes the same customers container component. I'm doing my initial fetching in componentDidMount function, which doesn't get triggered in route change, as component stays in the DOM. Component necessarily doesn't receive new props either.
One solution would be to customize router link with fetch action being dispatched based on the href, but I'm pretty sure this is an anti-pattern, as it complicates code a lot, is hard to maintain, mixes concerns, and may result in a double fetch if target route didn't contain the component already.
Does React provide any lifecycle hook or mechanism that allow me to fetch in response to navigation event alone?
I'm using React-router-component and Redux.
A:
As far as I understand both tabs happen to contain the same component and so React re-uses the DOM and doesn't create a new component instance, right?
You can use React's special key prop to force React to replace a specific instance.
E.g.:
<div className="tab-content>
<div key="tab-1" className="shared-component-across-tabs">
shared-component-across-tabs
</div>
</div>
And in the second tab you'd use key="tab-2".
Otherwise your route handler component will receive props.location.pathname from the router. You can also implement componentWillReceiveProps and check if the pathname has changed and re-fetch the data in that case.
using N2;
using N2.Details;
using N2.Integrity;
using N2.Templates.Items;
using N2.Web.UI.WebControls;
using N2.Definitions;
using N2.Web.UI;
namespace N2.Templates.Items
{
[PartDefinition("Social bookmarks",
IconUrl = "~/Templates/UI/Img/digg.png")]
[RestrictParents(typeof(IPage))]
[AllowedZones(Zones.SiteRight, Zones.Right, Zones.RecursiveRight, Zones.SiteLeft)]
[RestrictCardinality]
[FieldSetContainer("SocialTargets", "Social buttons for", 100)]
public class SocialBookmarks : AbstractItem
{
[EditableCheckBox("Facebook", 100, ContainerName = "SocialTargets")]
public virtual bool Facebook
{
get { return GetDetail("Facebook", true); }
set { SetDetail("Facebook", value, true); }
}
[EditableCheckBox("Google+1", 110, ContainerName = "SocialTargets")]
public virtual bool GooglePlus1
{
get { return GetDetail("GooglePlus1", true); }
set { SetDetail("GooglePlus1", value, true); }
}
[EditableText(SortOrder = 110)]
public override string Title
{
get { return base.Title; }
set { base.Title = value; }
}
[EditableCheckBox("Like whole site", 120, HelpTitle = "This setting will make it so the whole site rather than the currently displayed page is liked")]
public virtual bool LikeSite
{
get { return GetDetail("LikeSite", true); }
set { SetDetail("LikeSite", value, true); }
}
protected override string TemplateName
{
get { return "SocialBookmarks"; }
}
}
}
It was more than 20 years ago that the B.C. Liberal Party, then in opposition, attacked the NDP government of the day for bestowing special favour upon its "friends and insiders." After 16 years in power, however, the Liberals are entrenched in defending a political fundraising system that sells access and influence to its own friends and insiders.
As early as this week, the B.C. Liberal government will acknowledge demands for campaign finance reform with legislation to improve disclosure of those contributions. Unless they divert wildly from the script laid down by Premier Christy Clark, the bill will not curb the lucrative business of trading cash for access.
A Globe and Mail investigation on Saturday revealed that lobbyists and government consultants, paid by corporations or special-interest groups to try to influence politicians, are milked by the party in power for multiple donations in exchange for a retailed commodity: Access to the Premier and members of her cabinet.
Story continues below advertisement
Globe Investigation: How B.C. lobbyists are breaking one of the province's few political donation rules
Related: Elections B.C. probes Liberal Party fundraising
Gary Mason: Global ridicule won't stop B.C. Liberals' deceitful financing extravaganza
In 2016, the B.C. Liberals raised a total of about $12.4-million in political donations – $4.5-million from individuals and $7.9-million from corporations. The large corporate donations tend to attract the most attention, but lobbyists are making substantial donations with smaller, but frequent |
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] | had “blood all over” telling him she had had a miscarriage.
He said he helped clean up the blood and flushed what he now knew to be the placenta down the toilet.
‘Cause unascertained’
When asked by the coroner how his daughter ended up in Bluebell Woods he replied: “Because she put her there.
“No-one else knew about her daughter.”
Pathologist Dr Charles Wilson told the inquest he did not believe Pearl’s body had been at the woodland for long because decomposition would have been greater.
The medical cause of death was unascertained.
Recording a narrative verdict, Manchester North senior coroner Joanne Kearsley concluded Pearl was delivered on 25 December 2017 at between 32 and 40 weeks in a viable pregnancy but because of decomposition it was not possible to know whether she was born alive or stillborn.
She added her delivery was concealed and she was stored in an unknown place until or around 4 April.Authors
Abstract
The optimal choice of sites to make spatial prediction is critical for a better understanding of really spatio-temporal data. It is important to obtain the essential spatio-temporal variability of the process in determining optimal design, because these data tend to exhibit both spatial and temporal variability. Two new methods of prediction for spatially correlated functional data are considered. The first method models spatial dependency by fitting variogram to empirical variogram, similar to ordinary kriging (univariate approach). The second method models spatial dependency by linear model co-regionalization (multivariate approach). The variance of prediction method was chosen as the optimization design criterion. An application to CO concentration forecasting was conducted to examine possible differences between the design and the optimal design without considering temporal structure.A French housewife found guilty of sexually abusing two plumbers who had visited her house to mend a leak today has apologised to the men.
Identified only by her initials of I.D, the 50 year old said she was determined to turn over a new leaf and become a life coach.
On Wednesday a court in Arras, northern France, found her guilty of abusing the men when they visited her flat in October last year.
The 50-year-old French housewife made lewd suggestions to a pair of plumbers and rubbed up against their bottoms. When they resisted her advances she reacted furiously, smacking one of them across the face
Rather than allowing them to get on with their work, she forced herself against their bottoms when they were bending over, and made lewd suggestions.
‘When you have done with the radiators, come to my bed,’ was one of her suggestions, the court heard.
The men were not interested in sex, but that did not stop the women closing the shutters of her flat and making further propositions.
When shunned further, the woman smacked one of the men across the face, before throwing them both out of her home, Voix du Nord newspaper reported.
In their panic, the men left their tools behind, leaving the police to retrieve them the next day.
The woman, who had a serious alcohol problem, also attacked police officers.
She was given a 12 month suspended prison sentence and told to seek treatment for her heavy drinking.
I.D. told the court: ‘I’ve now decided to take my life in hand. I’ve not drunk for more than eight months, and I’ve started training to be a life coach.’Background
==========
In the United States and many Western nations, the need for containment of health care costs is rising \[[@B1]\]. Between 2000 and 2010, increases in per capita health care expenses reached 71.9 percent in the United States, 76.4 percent in Canada, 61.9 percent in Germany, and 87.2 percent in the United Kingdom. Expenses were substantially higher in the United States than in the other nations throughout this period \[[@B2]\]. Recent discussions concerning containment of health care expenditures have generated a high level of interest in connecting a portion of provider reimbursement to outcomes indicators such as hospital inpatient readmissions and complications \[[@B3]\].
In this context, hospital readmissions have generated considerable attention. Reduction of readmissions holds the potential for elimination of large numbers of inpatient hospitalizations and the payments associated with them \[[@B4],[@B5]\]. Further payer revenue could be generated through financial penalties for excess readmissions by providers whose rates could not be reduced. The Medicare program has already developed and implemented financial penalties based on excess readmission levels \[[@B3],[@B6]-[@B8]\].
This increased interest in hospital outcomes has supported the need for clear and useful clinical definitions and designations of patients who are readmitted. Historically, these patients have frequently been identified by the principal diagnosis of the initial admission that preceded the readmission, such as heart failure, pneumonia, or acute myocardial infarction \[[@B9],[@B10]\]. Such designations are necessary for effective identification and management of these patients. The potential for developing such definitions has also been supported by the development of computerized algorithms to track and evaluate readmissions using provider data \[[@B11]\].
This brief report focused on evaluation of clinical definitions and designations of patients who are readmitted to hospitals. Through data from hospitals in one community, it evaluated examples of two major diagnoses of these patients and suggested implications for their management.
The study involved readmissions in the hospitals of Syracuse, New York. These acute care facilities, with 2012 inpatient discharges excluding well newborns, include Crouse Hospital (20,715), St. Joseph's Hospital Health Center (25,743), and Upstate University Hospital (27,600). The primary and secondary acute care service area for these hospitals includes a population of approximately 575,000. The combined hospitals also serve as the tertiary referral center for the eleven county Central New York Health Service Area with a population of 1,405,221 (New York Statistical Information System, 2012).
Historically, the Syracuse hospitals have employed a combination of cooperation and competition to improve health care efficiency and outcomes in the service area. A number of cooperative efforts have been developed through the Hospital Executive Council, the collaborative planning organization for the hospitals \[[@B12]\].
This study was developed through a partnership between the Hospital Executive Council and 3 M™ Health Information Systems. It involved analysis of hospital readmissions in the Syracuse hospitals during a two year period using the 3 M™ HIS Potentially Preventable Readmissions software \[[@B13]\].
Findings
========
Provider studies of patients readmitted to hospitals has frequently identified these patients by the principal diagnosis of the initial admission that preceded the rehospitalizations. This approach has frequently caused efforts to manage these outcomes to be based on that diagnosis. This designation has also been reflected in Medicare's readmission payment methodology, the first phase of which involved patients with initial admissions for heart failure, pneumonia, and acute myocardial infarction \[[@B14],[@B15]\].
In order to evaluate the effectiveness of this approach to identifying patients who are subsequently readmitted, two of these populations were evaluated in the Syracuse hospitals. Patients with a principal diagnosis of congestive heart failure (APR DRG 194) and pneumonia (APR DRGs 138--139) are two diagnoses frequently associated with these patients. Both diagnoses were used to identify patients in the Medicare readmissions program.
For patients with each of these APR DRGs on initial admission, data identifying readmission APR DRGs for each of the three Syracuse hospitals were generated for January-December 2011 and 2012. Combined data for the three hospitals were also identified. The analysis focused on comparison of readmission APR DRGs with initial admission APR DRGs for each hospital by year and quarter during the two year period.
The first section of the analysis involved comparisons of initial and readmission diagnoses for patients with an initial admission for heart failure during the two year period. Relevant data are summarized in Table [1](#T1){ref-type="table"}.
######
Principal diagnosis of readmission, initial admission-congestive heart failure (APR DRG 194), Syracuse hospitals, 2011-2012
**Number of readmission** **Percent of total**
----------------------------------------- --------------------------- ---------------------- ---- ---- ---- ----- ------- -------
Crouse Hospital
1Q 2011 3 1 4 1 0 9 33.33 66.67
1Q 2012 18 1 3 0 3 27 66.67 33.33
2Q 2011 7 1 3 2 0 13 53.85 46.15
2Q 2012 3 0 2 2 0 7 42.86 57.14
3Q2011 10 0 1 1 0 13 76.92 23.08
3Q 2012 6 3 1 0 1 14 42.86 57.14
4Q 2011 7 1 2 1 0 15 46.67 53.33
4Q 2012 4 0 2 2 2 10 40.00 60.00
Total 2011 27 3 10 5 0 50 54.00 46.00
Total 2012 31 4 8 4 6 58 53.45 46.55
St Joseph's Hospital Health Center
IQ 2011 7 3 3 1 0 13 5385 46.15
1Q 2012 |
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] | uka I as Yamabuki in the play Goban Tadanobu yuki no nachiguro, Ichimura Theater, XI/1848. ōban triptych. Library of Congress.
##
Iseya Kanekichi
late 1840s–c.1875
Seal name: Isekane. Located at Akasaka Shinmachi Sanchōme (c.1851–56), then Nihonbashi Tomimakichō, later Kyōbashi Nakabashi Minamimakichō (since c.1873).
In the late 1840s, Iseya Kanekichi started to issue actor prints by Kunisada. Having a good nose for current buyer interests, he immediately went into producing half-length actor portraits that are different from the standard full-length stage scenes as well as prints serving the Genji boom.
In 1851, only a few years after working as a publisher, Iseya became a member of the New Faction (Karigumi) of the Picture Book and Print Publishers Guild (Jihon toiya).
In 1852, the year when actor bust portraits boomed, Iseya issued amongst others Kunisada's series "The Imaginary Thirty-Six Selected Poets" (Mitate sanjūrokkasen no uchi), 36 designs in total. Compositions like this are seen in many of Iseya's productions. The figure at the top left of the opposite page illustrates "The Imaginary Twelve Months" (Mitate jūnikagetsu no uchi), a small series that Kunisada did in 1859 with the help of his student Kunihisa II.
Another, very successful bust portrait series was published by Iseya from 1861 until 1863. "Modern Version of the Heroes of the Water Margin" (Kinsei suikoden) consists of 36 actor portraits, each furnished with a text by the writer Kanagaki Robun (1829–1894) describing the story of the portrayed hero.
In 1863, Iseya produced 11 of the 162 designs of the "Processional Tōkaidō" ("Go-jōraku Tōkaidō") series, the most extensive print series that was ever undertaken.
Iseya Kanekichi's last known prints date to 1875.
1852 Kunisada. The actor Matsumoto Kōshirō V as Ishikawa Goemon juxtaposed to Sosei-hōshi, from the series "The Imaginary Thirty-Six Selected Poets" (Mitate sanjūrokkasen no uchi). ōban. Collection Arendie and Henk Herwig.
1862 Kunisada. Act 8—The actors Bandō Hikosaburō V as Tonase and Sawamura Tosshō II as Konami, from an untitled series on the Treasury of Loyal Retainers. ōban. Japan Ukiyo-e Museum, Matsumoto.
Works | Date | Artist(s)
---|---|---
unserialized actor prints | | Kunichika, Kunisada, Kunisada II, Yoshitoshi, Yoshitsuya
unserialized beauty prints | | Hiroshige III, Kunisada
unserialized Genji prints | | Kunisada
unserialized landscape prints | | Hiroshige II, Hiroshige III, Kuniteru II, Yoshitora
unserialized sumo prints | | Kunisada
unserialized warrior prints | | Yoshikazu
Untitled series of actors in mirror reflections in half-length format | 1850-52 | Kunisada
Genji monogatari gojuyojo | 1852 | Hiroshige
Mitate sanjurokkasen no uchi | 1852 | Kunisada
Kiso rokujūkyū tsugi | 1852 | Kunisada
Yakusha mitateTōkaidō gojūsan tsugi | 1852 | Kunisada
Kisokaido rokujūkyū tsugi no uchi | 1852-53 | Kuniyoshi
Untitled series of Genji prints related to sounds | 1852-54 | Kunisada
Fūryū Genji | 1853 | Kunisada/Hiroshige
Azuma Genji setsugekka no uchi | 1854-55 | Kunisada
Chūshingura meimei den | 1855 | Kunisada
e-kyōdai mitate shichifuku | 1856 | Kunisada
Mitate sanjurokkusen | 1856-57 | Gengyo, Kunisada
Honchō Meishō kagami | 1858 | Yoshikazu
Mitate junikagetsu no uchi | 1859 | Kunisada/Kunihisa II
Kinsei suikoden | 1861-63 | Kunisada
Untitled Chūshingura series | 1862 | Kunisada
"Go-joraku Tōkaidō" | 1863 | Hiroshige II, Kunisada, Kunisada II, Kyosai
nijūshikō Imayō bijin | 1863 | Kunisada
Atari kyōgen nibanme taisetsu jōruri | 1864 | Kunisada
Suehiro gojūsan tsugi | 1865 | Sadahide
Jihitsu sanjurokku awase | 1865 | Kunisada II
Mitate iroha awase | 1866 | Kunichika
Nihon Meishō no uchi | 1866 | Kunichika
Tōkaidō hitome senryo | 1867 | Kunichika/Hiroshige II
Tōkyō fuka jiman kurabe | 1874 | Hiroshige III
1859 Kunisada and Kunihisa II. "Fifth month:" the actor Kawarazaki Gonjūrō I as Yanone Gorō, from the series "The Imaginary Twelve Months" (Mitate jūnikagetsu no uchi). ōban. Collection Arendie and Henk Herwig.
1861 Kunisada. The actor Nakamura Fukusuke II as Kasagawa Higezō, from the series "Modern Version of the Heroes of the Water Margin" (Kinsei suikoden). ōban. Japan Ukiyo-e Museum, Matsumoto.
1854 Kunisada. The actors Bandō Shuka I as Hitomaru Oroku and, in a round inset picture, Arashi Rikan III as Jiraitarō in the play Azuma kudari gojūsan tsugi, Kawarazaki Theater, VIII/1854. ōban. Japan Ukiyo-e Museum, Matsumoto.
1863 Hiroshige II and Kunisada II. "Enoshima", from the series known as "Processional Tōkaidō" ("Gō-jōraku Tōkaidō"). ōban. Collection Erich Gross, Switzerland. Marks 2007, no. 05F (28).
1852 Kunisada. The actor Nakamura Nakazō II as Toneri Matsuōmaru juxtaposed to ōnakatomi Yoshinobu, from the series "The Imaginary Thirty-Six Selected Poets" (Mitate sanjūrokkasen no uchi). ōban. Collection Arendie and Henk Herwig.
1852 Kunisada. The actor Ichikawa Kodanji IV as the ghost of Kasane juxtaposed to Fujiwara no Toshiyuki Ason, from the series "The Imaginary Thirty-Six Selected Poets" (Mitate sanjūrokkasen no uchi). ōban. Collection Arendie and Henk Herwig.
1854 Kunisada. The actors Ichikawa Komazō VII as Abe no Munetō and Arashi Koroku V as Sodehagi in the play ōshū Adachigahara, Ichimura Theater, IX/1854. ōban. Collection Arendie and Henk Herwig.
##
Maruya Tetsujirō
c.1849–97
Seal name: Marutetsu; firm name: Enjudō; family name: Kobayashi Tetsujirō. Located at Nihonbashi-dōri Nichōme 4-banchi (until 1878), Nihonbashi-dōri Sanchōme 13-banchi (1879 until at least 1884), then at Kanda Urajinbōchō 6-banchi (around 1895).
Maruya was first a publisher of nagauta libretti. It is not clear if the fan prints by Toyokuni and Kunisada published between 1814 and 1817 were issued by him as the publishing seal used on this prints was used by other publishers as well. The earliest designs that can be safely assigned to Maruya date from the late 1840s. At that time he engaged Kuniyoshi and |
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] | and also with some of the categories of the Sāmkhya system.21_
Śamkara's criticisms here are quite mild and are focused mainly on the theory of _vyūhas_.
We have, in what precedes, refuted the opinion of those who think that the Lord is not the material cause but only the ruler, the operative cause of the world. We are now going to refute the doctrine of those according to whom he is the material as well as the operative cause.—But, it may be objected, in the previous portions of the present work a Lord of exactly the same nature, i.e. a Lord who is the material, as well as the operative, cause of the world, has been ascertained on the basis of Scripture, and it is a recognized principle that _sm ti_ , in so far as it agrees with Scripture, is authoritative; why then should we aim at controverting the doctrine stated?—It is true, we reply, that a part of the system which we are going to discuss agrees with the Vedānta system, and hence affords no matter for controversy; another part of the system, however, is open to objection, and that part we intend to attack.
The so-called Bhāgavatas are of opinion that the one holy ( _bhagavat_ ) Vāsudeva, whose nature is pure knowledge, is what really exists, and that he, dividing himself fourfold, appears in four forms ( _vyūha_ ), as Vāsudeva, Sa karśa a, Pradyumna, and Aniruddha. Vāsudeva denotes the highest Self, Sa karśa a the individual soul, Pradyumna the mind ( _manas_ ), Aniruddha the principle of egoity ( _aha kāra_ ). Of these four Vāsudeva constitutes the ultimate causal essence, of which the three others are the effects.—The believer after having worshiped Vāsudeva for a hundred years by means of approach to the temple ( _abhigamana_ ), procuring of things to be offered ( _upādāna_ ), oblation ( _īgyā_ ), recitation of prayers, &c. ( _svādhyāya_ ), and devout meditation ( _yoga_ ), passes beyond all affliction and reaches the highest Being.
Concerning this system we remark that we do not intend to controvert the doctrine that Nārāya a, who is higher than the Undeveloped, who is the highest Self, and the Self of all, reveals himself by dividing himself in multiple ways; for various scriptural passages, such as "He is onefold, he is threefold" (Ch. Up. VII, 26, 2), teach us that the highest Self appears in manifold forms. Nor do we mean to object to the inculcation of unceasing concentration of mind on the highest Being which appears in the Bhāgavata doctrine under the forms of reverential approach, &c.; for that we are to meditate on the Lord we know full well from _sm ti_ and Scripture. We, however, must take exception to the doctrine that Sa karśa a springs from Vāsudeva, Pradyumna from Sa karśa a, Aniruddha from Pradyumna. It is not possible that from Vāsudeva, i.e. the highest Self, there should originate Sa karśa a, i.e. the individual soul; for if such were the case, there would attach to the soul non-permanency, and all the other imperfections which belong to things originated. And thence release, which consists in reaching the highest Being, could not take place; for the effect is absorbed only by entering into its cause.—That the soul is not an originated thing, the teacher will prove later on (II, 3, 17). For this reason the Bhāgavata hypothesis is unacceptable. (II, 2, 42)
The Bhāgavata hypothesis is to be rejected for that reason also, that observation never shows us an instrument, such as a hatchet and the like, to spring from an agent such as Devadatta, or any other workman. But the Bhāgavatas teach that from an agent, viz. the individual soul termed Sa karśa a, there springs its instrument, viz. the internal organ termed Pradyumna, and again from this offspring of the agent another instrument, viz. the _aha kāra_ termed Aniruddha. Such doctrines cannot be settled without observed instances. And we do not meet with any scriptural passages in their favor. (II, 2, 43)
Let us then—the Bhāgavatas may say—understand by Sa karśa a, and so on, not the individual soul, the mind, &c., but rather Lords, i.e. powerful beings distinguished by all the qualities characteristic of rulers, such as pre-eminence of knowledge and ruling capacity, strength, valor, glory. All these are Vāsudevas free from faults, without a substratum (not sprung from _pradhāna_ ), without any imperfections. Hence the objection urged in Sūtra 42 does not apply.
Even on this interpretation of your doctrine, we reply, the "nonexclusion of that," i.e. the non-exclusion of the impossibility of origination, can be established.—Do you, in the first place, mean to say that the four individual Lords, Vāsudeva, and so on, have the same attributes, but do not constitute one and the same Self?—If so, you commit the fault of uselessly assuming more than one Lord, while all the work of the Lord can be done by one. Moreover, you offend thereby against your own principle, according to which there is only one real essence, viz. the holy Vāsudeva.—Or do you perhaps mean to say that from the one highest Being there spring those four forms possessing equal attributes?—In that case the objection urged in Sūtra 42 remains valid. For Sa karśa a cannot be produced from Vāsudeva, nor Pradyumna from Sa karśa a, nor Aniruddha from Pradyumna, since (the attributes of all of them being the same) there is no supereminence of any one of them. Observation shows that the relation of cause and effect requires some superiority on the part of the cause—as, for instance, in the case of the clay and the jar (where the cause is more extensive than the effect)—and that without such superiority the relation is simply impossible. But the followers of the Pāñcarātra do not acknowledge any difference founded on superiority of knowledge, power, &c. between Vāsudeva and the other Lords, but simply say that they all are forms of Vāsudeva, without any special distinctions. The forms of Vāsudeva cannot properly be limited to four, as the whole world, from Brahman down to a blade of grass, is understood to be a manifestation of the supreme Being. (II, 2, 44)
## Footnotes
1. This does not mean that after Śamkara Indian philosophy is to be identified with Vedānta. Several schools maintained their tradition and at times offered counter arguments to the Vedāntic criticisms of their doctrines. (See for example _Sāmkhyapravacanasūtra_ , I, 150–152, for the arguments employed by the Sāmkhya system against Vedānta.)
2. See Daniel H. H. Ingalls, "Śamkara's Arguments Against the Buddhists," _Philosophy_ _East and West_ , vol. 3, no. 4 (Honolulu: University of Hawaii Press, 1954), pp. 291–306.
3. See pp. 150–151 for a description of the status of Śamkara's commentary on the _Brahmasūtras_ in the Advaitic school of Vedānta.
4. Another important Sāmkhyan work is the _Sāmkhyapravacanasūtra_ , once ascribed to Kapila but now believed to have been written in the fourteenth century. Vācaspati's _Tattvakaumudī_ , Gaudapāda's _Sāmkhya-Kārikā-bhāsya_ , Aniruddha's _Sāmkhyasūtrav tti_ , and Vijñānabhik u's _Sāmkhyapravacanabhāsya_ are also part of the basic primary literature. A. B. Keith's _The Sāmkhya System_ (London: Oxford University Press, 1918) is a good exposition of the Sāmkhya in its relations to other Indian systems of thought.
5. The existence of _prakrti_ is inferred, according to the Sāmkhya, on grounds such as (1) the finite objects of the universe must be dependent upon something else because of their very finitude, and (2) all individual objects possess certain similar characteristics (e.g., their being subject to pleasure and pain) and this is intelligible only when they are referred to a common source (See _Sāmkhya-Kārikā_ , XV). The existence of the _purusa_ is also argued on grounds such as (1) experience is unintelligible without a coordinating consciousness; (2) all composite objects exist for the use of a spiritual |
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] | muscles. And though the couch wasn't particularly soft — it felt like solid rock — I was almost submerged in it.
But that was unimportant. What mattered was this — somehow the lifeship had to escape from Earth's gravity, and sometime it had to land on Mars. There wasn't enough fuel to do it. I could see that now, only a matter of seconds from takeoff. Ten people, lower down in the lifeship, were depending on me and on the ship for life that the ship and I weren't going to be able to give them.
I was thinking like a prairie fire, though I was practically certain there was no solution. Soon I had a little piece of an answer. My fingers moved and the blast mounted. Anyone below who had thought nothing could be worse than 6G found his mistake as the acceleration went up and up.
The ship was designed for four minutes' blasting, but if I were to save fuel there was only one way to do it. That was to get off more quickly, reach escape velocity, and stop blasting sooner, saving the fuel which would have been needed to hold the ship up during the extra time.
I refused to think about the jet linings. They were designed for four minutes' blast, presumably, and now they were being asked to take the same thrust in less time.
I nearly blacked out. I screamed and hardly heard myself. You won't understand how I felt physically unless the same kind of thing has happened to you — when you must and do remain conscious but you're so near unconsciousness that perceptions sent along the nerve channels to your brain simply don't leave any record there. You have to notice them as they happen or you've lost them forever.
I strained my eyes at the dials in front of me, trying to make them mean that I could cut the drive. They persisted in telling the truth, which was no good to me. I saw why people sometimes strain to believe something they know is false. There are times when hopeful fantasy is much more attractive than hopeless fact.
At last I was able to cut the drive. It had been on for hours. The chronometer said it was only three minutes or so, but I knew better. It didn't stop cleanly, as it should, it eased off gently. The couch gradually rose, and I floated off, weightless.
You never quite get used to free fall, no matter how often you experience it. It's a surprise every time when up and down disappear from the environment and the normal way of getting about ceases to be beetlelike and becomes birdlike. It's amusing or frustrating, depending on how you're feeling at the time, when you want to go one way and find yourself going the other, impelled by some tiny movement of air you can't see and normally wouldn't notice at all.
The body adjusts to the new conditions more quickly than the mind. The lungs and heart and stomach, puzzled for a few minutes by the absence of gravity, soon learn their new job and do it as well as they did the old one. Clothes and hair are inconveniences, though. Practically every garment of civilization except riding breeches and bathing costumes depends to some extent on gravity to hold it in place. Whenever I moved, my jacket began to ride up about me like water wings, and my trousers gradually worked themselves in untidy folds up my legs, showing the imprex tape underneath.
I found Mars through the tungsten glass ports and began to check on the old space navigators' Irishism — whether it would be where we were when we got there. But I wasn't allowed much grace. Sammy Hoggan came in, his face grim.
"Mary Stowe's dead," he said briefly.
I couldn't understand that at first. Somebody dead — already? It interfered with my long-term calculation that we were all going to die. It jammed the works for a moment, this curious, irrelevant intimation that someone hadn't waited for the execution that appeared to be planned for us all.
"Acceleration?" I asked.
"That and her couch collapsing. It couldn't take the strain. Bill — didn't you accelerate more than you were supposed to?"
"Yes," I said.
"Then that killed her," he said bluntly. "The extra weight came on — and the couch broke. That was — "
I had heard enough about Mary, and it was too late to do anything about her. "Go away," I said.
Sammy swore. "Dammit, Bill," he said hotly, "you're responsible for all of us. You're the man in charge. Is that all you have to say? If you had to do it — "
I turned and looked coldly at him. "I'm responsible for getting this ship to Mars," I said curtly. "I'm not leaving here until I'm satisfied about that — not if the whole lot of you die. If this room had a door, I'd lock it to keep you all out. Now go and leave me alone. I'm sorry, Sammy, but I haven't time to be civil."
I went back to my calculations. I didn't notice Sammy going.
The first check was encouraging, as far as it went. There could be no precision about flying a lifeship — navigation with mass-produced instruments, and very few of them at that, was little more than an affair of pointing the ship's nose in roughly the right direction and praying.
And on this basis, it looked as if I could leave the course as it was and not waste any of my precious moluone making corrections. I wasn't too sure of our velocity — that would take days of checking by the planets — but it seemed that in about a hundred days the lifeship, in free fall, and Mars, in its orbit round the sun, would have reached about the same spot.
Then, more carefully, I worked out how much fuel I'd need for a safe landing on Mars, how much I had, and tried to close the gap. Mathematically it couldn't be done. I just couldn't land safely on Mars, according to my quadruple-checked figures.
I covered sheet after sheet with laborious calculation. The best I could produce, the most favorable extrapolation, crooked, weighted mathematics though it was, was still a very slim chance indeed.
Drugged with figures, working more and more from sheer obstinacy, stubbornly trying everything I could think of to try, I came up with the conclusion that our chances of getting to Mars, when we left the soil of Earth, had been about a thousand to one against. And they weren't very much better now.
True, we were clear of Earth and on a good course for Mars. We _were_ over the first hurdle. We had accomplished what, at a guess, only two or three hundred thousand of the seven hundred thousand lifeships had been able to do.
And of those two or three hundred thousand, many must have used all their fuel in tearing themselves free of Earth. Those ships were utterly helpless. Some of them would be shooting off in all directions, every moment getting farther from Mars, and utterly incapable of doing anything about it. Some of them would be pointed at the sun, or close enough to the sun to be captured by it. Some would move on and on past the planets into space... those ships would go on forever if they weren't captured by some star or planet.
I didn't swear or curse at anyone. I just doggedly worked out problem after problem, as if I could set everything right by my high school mathematics.
On the basis of our own experience I worked out how much fuel the lifeships really needed. Then, since they would have to be so much bigger and stronger, how many lifeships there would have been instead of seven hundred thousand. How many people they could have taken.
Allowing a very small safety factor, it came out at ninety-seven thousand. A chance of life for a million people instead of nearly eight million. Not one in three hundred of the people of Earth, but one in twenty-two hundred.
I tried to imagine the job I might have had then, the job of picking out ten people from a town of over twenty thousand. As it was, I knew hardly anything about some of the people I'd chosen from a mere three thousand or so. Sammy, Leslie, Betty, and Morgan were all last-minute choices, because someone else had had to come off the list. On the whole I was prepared to gamble on the first two, but Morgan and Betty could be my best choice or my worst for all I knew. What sort of guess could I have made if I'd been confronted with twenty thousand people and told to pick ten?
I shook my head wearily. The questions were too big for me. I had juggled too long with figures of life and death — a little life and a lot of death. They weren't anything but figures to me. Perhaps that was why I had done it — to reduce humanity's most frightful disaster to a few real figures, like four and seven and three, with a lot of incomprehensible zeroes after them.
I would come again, no doubt. But meantime I had reached a mental dead stop.
# _2_
I gave myself a push against the wall, guided myself with my arms, and swam out into the main room of the lifeship, which Sammy had already christened, ironically, "the lounge."
Lifeships were simply moving barns. There was nothing to be |
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] | .html">IntVector</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.cstringkernel-module.html">PyML.containers.ext.cstringkernel</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.containers.ext.csequencedata.LongVector-class.html#iterator">iterator()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.csequencedata.LongVector-class.html">LongVector</a>)</span></td>
</tr>
<tr>
<td width="33%" class="link-index"><a href="PyML.containers.ext.caggregate.DoubleVector-class.html#insert">insert()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.caggregate.DoubleVector-class.html">DoubleVector</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.containers.ext.cvectordataset.IntVector-class.html">IntVector</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.cvectordataset-module.html">PyML.containers.ext.cvectordataset</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.containers.ext.csequencedata.StringVector-class.html#iterator">iterator()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.csequencedata.StringVector-class.html">StringVector</a>)</span></td>
</tr>
<tr>
<td width="33%" class="link-index"><a href="PyML.containers.ext.caggregate.IntVector-class.html#insert">insert()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.caggregate.IntVector-class.html">IntVector</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.classifiers.ext.cgist-module.html#IntVector_swigregister">IntVector_swigregister</a><br />
<span class="index-where">(in <a href="PyML.classifiers.ext.cgist-module.html">PyML.classifiers.ext.cgist</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.containers.ext.csparsedataset.DoubleVector-class.html#iterator">iterator()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.csparsedataset.DoubleVector-class.html">DoubleVector</a>)</span></td>
</tr>
<tr>
<td width="33%" class="link-index"><a href="PyML.containers.ext.ckernel.DoubleVector-class.html#insert">insert()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.ckernel.DoubleVector-class.html">DoubleVector</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.classifiers.ext.csmo-module.html#IntVector_swigregister">IntVector_swigregister</a><br />
<span class="index-where">(in <a href="PyML.classifiers.ext.csmo-module.html">PyML.classifiers.ext.csmo</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.containers.ext.csparsedataset.FloatVector-class.html#iterator">iterator()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.csparsedataset.FloatVector-class.html">FloatVector</a>)</span></td>
</tr>
<tr>
<td width="33%" class="link-index"><a href="PyML.containers.ext.ckernel.FloatVector-class.html#insert">insert()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.ckernel.FloatVector-class.html">FloatVector</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.classifiers.ext.csvmodel-module.html#IntVector_swigregister">IntVector_swigregister</a><br />
<span class="index-where">(in <a href="PyML.classifiers.ext.csvmodel-module.html">PyML.classifiers.ext.csvmodel</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.containers.ext.csparsedataset.IntVector-class.html#iterator">iterator()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.csparsedataset.IntVector-class.html">IntVector</a>)</span></td>
</tr>
<tr>
<td width="33%" class="link-index"><a href="PyML.containers.ext.ckernel.IntVector-class.html#insert">insert()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.ckernel.IntVector-class.html">IntVector</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.classifiers.ext.knn-module.html#IntVector_swigregister">IntVector_swigregister</a><br />
<span class="index-where">(in <a href="PyML.classifiers.ext.knn-module.html">PyML.classifiers.ext.knn</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.containers.ext.csparsedataset.LongVector-class.html#iterator">iterator()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.csparsedataset.LongVector-class.html">LongVector</a>)</span></td>
</tr>
<tr>
<td width="33%" class="link-index"><a href="PyML.containers.ext.ckerneldata.DoubleVector-class.html#insert">insert()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.ckerneldata.DoubleVector-class.html">DoubleVector</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.containers.ext.caggregate-module.html#IntVector_swigregister">IntVector_swigregister</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.caggregate-module.html">PyML.containers.ext.caggregate</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.containers.ext.csparsedataset.StringVector-class.html#iterator">iterator()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.csparsedataset.StringVector-class.html">StringVector</a>)</span></td>
</tr>
<tr>
<td width="33%" class="link-index"><a href="PyML.containers.ext.ckerneldata.FloatVector-class.html#insert">insert()</a><br />
<span class="index-where">(in <a href="PyML.containers.ext.ckerneldata.FloatVector-class.html">FloatVector</a>)</span></td>
<td width="33%" class="link-index"><a href="PyML.containers.ext.ckernel-module.html#IntVector_swigregister">IntVector_swigregister</a><br />
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] | Sunday when both sides will be looking to maintain their early season challenge to five-time consecutive champions Juventus.
Roma, the 'giallorossi' (Yellow and Reds) are more widely supported, but the 'biancocelesti' (Skyblues) Lazio are the capital's original club
(AFP)
At the Olimpico, Lazio's hardline fans occupy the Curva Nord (North End) while Roma's hardline 'tifosi' are in the Curva Sud (South End).
Tragically, that rivalry has spilled over: in 1979, Lazio supporter Vincenzo Paparelli was killed by a distress flare launched from Roma's Curva Sud.
Totti, and only Totti
When it comes to territory in the Italian capital, Roma have the edge.
The 'Giallorossi' (Yellow and Reds) are more widely supported, but Lazio is the capital's original club having been founded in 1900, 27 years before four local clubs came together to form Roma under the aegis of the ruling fascist party.
"We were founded first and that pisses them off," said Guido, a Lazio supporter, after buying his ticket for Sunday's game.
In what was effectively a snub to former dictator Benito Mussolini, Lazio resisted the fascist party's attempts to fuse them with the other clubs in the capital.
But although Lazio have historical longevity, Roma have Totti.
The club's reputation has been boosted immeasurably over the years by the 40-year-old icon affectionately known as the 'King of Rome'.
The moniker is not exaggerated. From the auto garages of Monte Testaccio to the ice cream shops and bars around Trastevere, photos and murals of Totti are everywhere.
Totti has racked up an unrivalled tally of 41 derbies, won 14, lost 15 and scored an as-yet unbeaten 11 derby goals in the process.
In some of those, Totti provoked fans of Lazio most: notably lifting his shirt to reveal a message that said, 'I've purged you again', after scoring in a 3-1 Lazio win in 1999.
For Giulio Lucarelli, Totti's "special celebrations" mean only one thing: "For me, Totti is the derby."
But as derby fever intensifies, the Roma legend didn't miss a chance to add fuel to the fire.
Totti said: "Everyone is free to choose the team they want. Some are just luckier than others, that's all."Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men.
Resting metabolic rate (RMR) decreases with age, largely because of an age-related decline in fat-free mass (FFM). We hypothesized that a strength-training program capable of eliciting increases in FFM would also increase RMR in older individuals. To test this hypothesis, RMR, body composition, and plasma concentrations of certain hormones known to affect RMR were measured before and after a 16-wk heavy-resistance strength-training program in 13 healthy men 50-65 yr of age. Average strength levels, assessed by the three-repetition maximum test, increased 40% with training (P < 0.001). Body weight did not change, but body fat decreased (25.6 +/- 1.5 vs. 23.7 +/- 1.7%; P < 0.001) and FFM increased (60.6 +/- 2.2 vs. 62.2 +/- 2.1 kg; P < 0.01). RMR, measured by indirect calorimetry, increased 7.7% with strength training (6,449 +/- 217 vs. 6,998 +/- 226 kJ/24 h; P < 0.01). This increase remained significant even when RMR was expressed per kilogram of FFM. Strength training increased arterialized plasma norepinephrine levels 36% (1.1 +/- 0.1 vs. 1.5 +/- 0.1 nmol/l; P < 0.01) but did not change fasting glucose, insulin, or thyroid hormone levels. These results indicate that a heavy-resistance strength-training program increases RMR in healthy older men, perhaps by increasing FFM and sympathetic nervous system activity.Week seven of drawing Akko weekly. Not my best drawing, but I’ll be damned if I miss my weekly drawing challenge I’ve imposed on myself.
Also, don’t miss the final episode of LWA!! You guys hyped too or what??
Also, I’m still working on the next animation. I hope to have it done in the next two weeks or so. Production is going well.(30/29)/((-68)/1972)
-30
((-4)/6)/((83160/81)/(-40))
2/77
What is the value of ((84/3528)/((-6)/54))/((-36)/70)?
5/12
Evaluate (((-264)/1650)/(42/10))/((-1)/(-3)).
-4/35
What is the value of ((-44)/5)/((-27)/45)*(-6876)/(-3056)?
33
Calculate 35340/(-114)*((-2385)/(-150))/(-53).
93
Evaluate ((-180)/(-70))/((-1548)/16856).
-28
Calculate (-1*4/20)/((-46)/973590*-51).
-83
Calculate (-102)/(-9792)*-32*(-4)/(8/306).
51
What is (2/16*(-9)/((-324)/(-80)))/((-20480)/(-6144))?
-1/12
Calculate (-1)/2*141/(-1645)*7/(-6).
-1/20
(-2)/(155/(285200/1120))
-23/7
414/(-24)*((16/42)/(-4))/((-2572)/36008)
-23
Evaluate ((-36)/(-12))/((1848/(-814))/28).
-37
(148/14)/((-7644)/(-26754))
37
What is (69*6/(-1380))/(15/(-2050))?
41
What is ((-6)/(-8))/(((-12)/(-42))/(-21*144/(-55566)))?
1/7
What is (104/(-52))/((-56)/(-32))?
-8/7
What is the value of (((-48)/288)/(1/2))/((-3)/(-15120)*16)?
-105
(10/(-10))/((121/1936)/((16/(-2))/2))
64
What is the value of 190/(-228)*404/505?
-2/3
What is (-200)/(1230/4797*-12)?
65
Evaluate 104/1256*(-8)/(-20)*25/65.
2/157
What is the value of ((-4)/9)/((-1348)/(-78858))?
-26
What is 52920/7938*1/(-4)?
-5/3
What is the value of (-4*9/72)/((-7)/((-588)/(-3)))?
14
((-10)/(-6))/(((-1798)/(-290377))/(12/(-34)))
-95
What is (1/4)/(26/10192*-21)*6?
-28
What is ((9/21)/((-327)/(-1526)))/(4*5/90)?
9
4*(10/8)/((-563)/6193)
-55
Evaluate 264*-5*30/(-7200).
11/2
38/(-1729)*-26*49/(-42)
-2/3
Calculate 63/9*(-594)/756*4/6.
-11/3
((-198)/6)/(((-2)/14)/(2/(-21)))
-22
Evaluate (-3600)/108*(-18)/15*(-5)/8.
-25
645760/4036*(-6)/(-80)
12
Calculate 2/9*-1*(-4272)/14240.
1/15
What is the value of 464/(-36)*3420/760?
-58
What is the value of (3536/(-80))/13*(-30)/2*-1?
-51
Evaluate (6/(24/2))/(-4*28/640).
-20/7
What is (20/110)/(((-240)/15)/1232)?
-14
Evaluate (377/(-1508))/(9/18).
-1/2
What is (-3)/(12/(-14))*28*2175/7350?
29
Calculate (228984/66787)/(44/7).
6/11
Evaluate ((-20)/(-6))/((8/(-300)*-10)/(492/(-410))).
-15
Calculate (-88)/(-5)*(-101625)/27100.
-66
Calculate ((-516)/(-4644))/(30/(-162)).
-3/5
What is the value of (21/105)/((-12)/(300/(-5))*-6*1)?
-1/6
What is the value of 232812/679035*(-5)/3?
-4/7
100/30*272/(-204)*234/(-40)
26
What is the value of ((-856)/107)/(31/(24769/136))?
-47
What is the value of 16*(-40)/(4800/(-180))?
24
What is the value of (-696)/89262*(-95)/30?
2/81
|
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] | }}$ and $\partial_{\hat{\mu}} \chi = 0$, we are able to write a LV-action. These properties have a meaning that the SUSY breaks down and generates a non-null vector background $\xi$ and a non-null fermionic parameter $\chi$. The action is given by: $$S_{CPT-odd} = \int d^4 x d^4 \theta \Big{(} W^\alpha (D_\alpha V) S + W^{\dot{\alpha}} (D_{\dot{\alpha}} V) S \Big{)}, \label{susy3d60}$$ where $V$ is the Vector superfield in the Wess-Zumino gauge and $W^\alpha = -\frac{1}{4}(\bar{D})^2D^{\alpha} V $. Rewriting in terms of the component fields the total Lagrangian is written as, $\mathcal{L}_{tot-gauge} = \mathcal{L}_{A} + \mathcal{L}_{ph} + \mathcal{L}_{int-gauge}$, where $$\mathcal{L}_A = -\frac{1}{4}{F_{\hat{\mu} \hat{\nu}} }^2 + \frac{1}{2} \epsilon^{\hat{\mu} \hat{\nu} \hat{\alpha} \hat{\beta}} \xi_{\hat{\mu}} A_{\hat{\nu}} F_{\hat{\alpha} \hat{\beta}}. \label{susy3d65}$$ For the photino ($\lambda$) we have (with fermionic Lorentz breaking parameter $\chi$) $$\begin{aligned}
\mathcal{L}_{ph} &=& - \frac{i}{2} \bar{\lambda}\Gamma^{\hat{\mu}}\partial_{\hat{\mu}} \lambda + \phi \bar{\lambda} \lambda \nonumber \\
&-&i \rho \bar{\lambda} \Gamma_5 \lambda - \bar{V}_{\hat{\mu}} \bar{\lambda} \Gamma^{\hat{\mu}}\Gamma_5 \lambda, \label{susy3d70}\end{aligned}$$ with $\phi = \Big[Re(F)+ \frac{1}{4}\bar{\chi} \chi \Big]$ , $\rho = \Big[Im(F) + \frac{i}{4}\bar{\chi}\Gamma_5 \chi \Big]$ and $\bar{V}_{\hat{\mu}} = \frac{1}{4}\Big[V_{\hat{\mu}}+ \bar{\chi}\Gamma_{\hat{\mu}}\Gamma_5 \chi \Big]$. This procedure also given a new interaction term between the photon and the photino field, and this term is given by $$\mathcal{L}_{int-gauge} = \sqrt{2} \bar{\lambda}\Gamma^{\hat{\mu} \hat{\nu}} \Gamma_5 \chi F_{\hat{\mu} \hat{\nu}}. \label{susy3d75}$$
Now, we apply the dimensional reduction to the Lagrangean $\mathcal{L}_{tot-gauge} = \mathcal{L}_A + \mathcal{L}_{ph} + \mathcal{L}_{int-gauge}$.
From the dimensional reduction scheme of the Appendix, we write $A^{\hat{\mu}} = (A^\mu, \varphi)$ , $\lambda = \begin{pmatrix}\lambda_1 & \lambda_2 \end{pmatrix}^T$ and $\chi = \begin{pmatrix}\chi_1 & \chi_2 \end{pmatrix}^T$, we have $$\begin{aligned}
\mathcal{L}_A &=& -\frac{1}{4} F_{\mu \nu}^2 + \frac{1}{2}\partial_\mu \varphi \partial^\mu \varphi -\frac{\varphi}{4}\varepsilon^{\mu \nu \alpha} \xi_\mu \partial_\nu A_\alpha \nonumber\\
&-&\frac{1}{2}\xi_3 \varepsilon^{\mu \nu \alpha}A_\mu \partial_\nu A_\alpha. \label{susy3d80}\end{aligned}$$ The photino sector is given by $$\begin{aligned}
\mathcal{L}_{ph} \mspace{-6mu}&=& \mspace{-8mu}\begin{pmatrix}\bar{\lambda}_1 & \bar{\lambda}_2 \end{pmatrix}\begin{pmatrix}-\frac{i}{2} \gamma \cdot \partial + \phi - \bar{V}_3 & \rho - i \gamma \cdot \bar{V} \\ -\rho - i \gamma \cdot \bar{V} & \frac{i}{2} \gamma \cdot \partial + \phi + \bar{V}_3 \end{pmatrix} \nonumber\\
&\times&\mspace{-8mu}\begin{pmatrix}\lambda_1 \\ \lambda_2 \end{pmatrix}, \label{susy3d85}\end{aligned}$$ where $\bar{V}_{\mu} = \frac{1}{4}\Big[V_{\mu}+ \bar{\chi}\Gamma_{\mu}\Gamma_5 \chi \Big]$ and $\bar{V}_{\hat{\mu}} = \frac{1}{4}\Big[V_{\hat{\mu}}+ \bar{\chi}\Gamma_{\hat{\mu}}\Gamma_5 \chi \Big]$. The mixing terms can be rewritten as follows: $$\begin{aligned}
\mathcal{L}_{int-gauge} &= &\sqrt{2} i (\bar{\lambda}_1\gamma^{\mu \nu} \chi_2 + \bar{\lambda}_2\gamma^{\mu \nu} \chi_1)F_{\mu \nu} \nonumber\\
&+& \sqrt{2}(\bar{\lambda}_1\gamma^{\mu} \chi_2 + \bar{\lambda}_2\gamma^{\mu} \chi_1) \partial_\mu \varphi. \label{susy3d90}\end{aligned}$$ In a short way, we can rewrite the above equation as $\mathcal{L}_{int} = \bar{\Theta} \Upsilon $ , where $\bar{\Theta} = \begin{pmatrix}\bar{\lambda}_1 & \bar{\lambda}_2 \end{pmatrix}$ and $$\Upsilon =\sqrt{2} \begin{pmatrix}\gamma \cdot F & \gamma \cdot \partial \varphi \\ \gamma \cdot \partial \varphi & \gamma \cdot F \end{pmatrix} \begin{pmatrix} \chi_2 \\ \chi_1 \end{pmatrix}. \label{susy3d95}$$ Here $\gamma \cdot F = \gamma^{\mu \nu} F_{\mu \nu}$ and $\gamma \cdot \partial \varphi = \gamma^\mu \partial_\mu \varphi$. Manipulating the equation above and applying the same kind of shift used in the matter sector, we can rewrite the photino and mixing terms as $$\begin{aligned}
\mathcal{L}_{ph+ int} &=& \bar{\Theta} O(\partial) \Theta + \bar{\Theta} \Upsilon = \bar{\Theta} O(\partial)\Big(\Theta +\frac{1}{2} O^{-1}(\partial) \Upsilon \Big) \nonumber\\
&+& \frac{1}{2} \bar{\Theta} \Upsilon, \label{susy3d100}\end{aligned}$$ where $\tilde{O}(\partial) = \begin{pmatrix}-\frac{i}{2} \gamma \cdot \partial + \phi - \bar{V}_3 & \rho - i \gamma \cdot \bar{V} \\ -\rho - i \gamma \cdot \bar{V} & \frac{i}{2} \gamma \cdot \partial + \phi + \bar{V}_3 \end{pmatrix}$.
With the shift $\Theta \rightarrow \Theta + \frac{1}{2} \tilde{O}^{-1}(\partial) \Upsilon $ we have, finally $$\mathcal{L}_{ph+ int} = \bar{\Theta} \tilde{O}(\partial) \Theta - \frac{1}{4} \bar{\Upsilon} \tilde{O}^{-1} \Upsilon. \label{susy3d105}$$ Thus, the final action of the CPT-odd gauge sector will be given by $$\begin{aligned}
\mathcal{L}_{tot-gauge} &=& -\frac{1}{4} F_{\mu \nu}^2 + \frac{1}{2}\partial_\mu \varphi \partial^\mu \varphi -\frac{\varphi}{4}\varepsilon^{\mu \nu \alpha} \xi_\mu \partial_\nu A_\alpha \nonumber\\
&-&\frac{1}{2}\xi_3 \varepsilon^{\mu \nu \alpha}A_\mu \partial_\nu A_\alpha \nonumber\\
&-& \frac{1}{4} \bar{\Upsilon} \tilde O^{-1} \Upsilon + \begin{pmatrix}\bar{\lambda}_1 & \bar{\lambda}_2 \end{pmatrix} \tilde{O}(\partial) \begin{pmatrix}\lambda_1 \\ \lambda_2 \end{pmatrix}. \label{susy3d105b}
\end{aligned}$$
In summary then, we have obtained a complete $(2+1)$-dimensional Lagrangian, which defines a new electrodynamics. In the following Section we compute the interaction energy between static point-like sources for this new electrodynamics. Following the same steps as the ones presented in our previous works [@Belich: |
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] | cause” of ISIS except only in the sense that the “failure” to exact regime change in Syria has prompted the West to continue propping up ISIS and other terrorist groups until the government in Damascus falls – and only when Damascus’ regional and global allies abandon it.
The West Got What it Wanted in Libya – And Created ISIS in the Process
The West’s claims during the Vienna talks that if only they get their way in Syria, the threat of ISIS will subside, is betrayed by the events surrounding the very rise of ISIS in Syria in the first place.
Just before the conflict reached critical mass in Syria during 2011, the US, UK, France, other NATO members, as well as Saudi Arabia, Qatar, and the United Arab Emirates (UAE), were already in the process of fully dividing and destroying Libya in pursuit of regime change.
They insisted that regime change was the only way to end the bitter fighting that had swept the country – regime change that just so happened to fulfill the long-held desire by Washington and Europe to see Libyan leader Muammar Qaddafi ousted from power.
Through arming what the West called “rebels,” and through direct military intervention which included large-scale, nationwide airstrikes, naval bombardments, and even special forces, NATO devastated the country and turned it over literally to Al Qaeda. The West’s “rebels” turned out to be sectarian extremists all along, and in fact – with NATO’s help – they promptly took their weapons, fighters, and cash to begin the invasion of northern Syria via Turkey later that year.
The Business Insider would report in its article, “REPORT: The US Is Openly Sending Heavy Weapons From Libya To Syrian Rebels,” that:
The administration has said that the previously hidden CIA operation in Benghazi involved finding, repurchasing and destroying heavy weaponry looted from Libyan government arsenals, but in October we reported evidence indicating that U.S. agents — particularly murdered ambassador Chris Stevens — were at least aware of heavy weapons moving from Libya to jihadist Syrian rebels.
There have been several possible SA-7 spottings in Syria dating as far back as early summer 2012, and there are indications that at least some of Gaddafi’s 20,000 portable heat-seeking missiles were shipped before now.
On Sept. 6 a Libyan ship carrying 400 tons of weapons for Syrian rebels docked in southern Turkey. The ship’s captain was “a Libyan from Benghazi” who worked for the new Libyan government. The man who organized that shipment, Tripoli Military Council head Abdelhakim Belhadj, worked directly with Stevens during the Libyan revolution.
Belhadj, it should be mentioned, was the commander of US State Department-listed foreign terrorist organization, the Libyan Islamic Fighting Group (LIFG) – which is literally Al Qaeda in Libya – and was so before, during, and after the 2011 Libyan war. Belhadj was also reportedly aligned with ISIS as it officially established itself in the shattered North African state. Fox News would report in its article, “Herridge: ISIS Has Turned Libya Into New Support Base, Safe Haven,” that:
[Catherine] Herridge reported that one of the alleged leaders of ISIS in North Africa is Libyan Abdelhakim Belhadj, who was seen by the U.S. as a willing partner in the overthrow of Libyan dictator Muammar Gaddafi in 2011.
“Now, it’s alleged he is firmly aligned with ISIS and supports the training camps in eastern Libya,” Herridge said.
It is clear that despite Western claims that regime change in Libya would be the beginning of the end for Libya’s violence and instability, it was only the end of the beginning – and not only for chaos in Libya – but for other nations across North Africa and in Syria itself.
Using Another 9/11 to Justify Creating Another Libya
NATO’s intervention and regime change in Libya did not avert a refugee crisis, it helped create one. NATO’s intervention and successful regime change in Libya did not make the region or the world safer, it turned the entire nation into a breeding ground for terrorist organizations with so-far unprecedented reach and operational capacity. NATO’s goals in Libya did not prevent the refugee crisis, it helped start it. And with all of this in mind, having seen this and taken full stock of Libya’s outcome, the West has nonetheless moved forward with precisely the same agenda in Syria.
In all reality, the West has no intention of bringing peace or stability to Syria. Their goal is to leave Syria as divided and destroyed as Libya, and to use the chaos and instability fostered there as a springboard for other targets of the West’s proxy warfare – most likely Iran, Russia, and targets deeper in Central Asia.
The West promises that it will end the chaos in Syria, just like they promised it would end in Libya. It will not end in either.
With Libya’s fate in mind, and a repeat performance clearly taking shape in Syria should the West get its way, it must be made clear that no matter how many innocent people are killed by terrorists the West itself helped create and perpetuate, they will not get an opportunity to turn Syria into the “Libya of the Levant,” no matter how convenient and well-timed these killings are, no matter how deep they are within the heart of Europe or North America, and no matter how tragic and regrettable the aftermath is.
Tony Cartalucci, Bangkok-based geopolitical researcher and writer, especially for the online magazine“New Eastern Outlook”.In this instructable you will learn how to make a Q&D-Poor man's-Skinner-Sadist-Jeopardy game . First off, the disclaimer: I'm not responsible of whatever you do. You have to know that with a great power comes...bla-bla-bla. Just be careful and remember that electricity reserves respect. While the energy involved in this project is generally safe, it can be fatal (or at least very harmful) given certain ...
While being a bit lengthy and requiring experience with Arduino, this contraption is bound to grant you infinite glory among your friends, toddlers and grownups alike! Step 1: What You Need Here's a list of the materials and parts I used: The Frame * 5 x 4-feet long rectangular profile (0.5" x 0.5") pieces of wood, as solid as possible. Although you could probably get away with plywood if you wanted to, I a ...
Update! See Step 32 to find out how to use this project with a green laser! Also - checkout the LaserTweet Instructable to make this project display data from Twitter: http://www.instructables.com/id/LaserTweet-Twitter-Projecting-Laser-Show/ This project uses an Arduino and some cheap audio speakers to create a real laser show with full X and Y axis control. The included source code lets you easily draw tex ...
For the Smart Cities exhibition in Leeds in a couple of weeks, we’ve been building a physical representation of an agent based simulation. Hex Bug Spiders are relatively cheap hexapod robots that are controlled via an infra-red transmitter which has an A or B code so that you can control two simultaneously. The way it walks is referred to as the Jamius walking mechanism after its inventor (see: http://www.y ...
Idea: To take one of my old Playstation 1 controllers and extract the dual thumbstick setup so that it can be easily used in a microcontroller project (in my case: with the Arduino) without extra libraries or drivers that you would need if you want to use the entire controller. Please let me know what you think or if you have questions/criticism for me! I'm always looking to learn new things.Required materi ...
Make A "doorbell" using an Arduino Uno, a Wave shield from Adafruit, a small speaker, a plug, a Sharp distance sensor and a Shaun the Sheep. Our Shaun is used in an open doorway to alert store staff when a customer has entered. Step 1: Parts List 1. Wav Shield Party Pack (includes speaker and SD card) - $35 2. Arduino Uno - $30 3. Power plug - $7 4. Sharp Distance Sensor - $14.95 5. Shaun the Sheep found o ...
I bought this skull to decorate my computer desk. However, analyzing better, I could do something more interesting. I hope you enjoy. Step 1: Materials - A plastic skull - 8 screws; - Microcontroller (I used an Arduino board); - A Protoboard - A nunchuck (for nintendo wii control) with a adaptador Note: I bought the adapter but can be easily made by following this step by step: http://www.instructables.com/ ...
Welcome to my 3rd Instructable everyone ! Today we're going to build a 'device' to control a mini-sized helicopter with a Wii Nunchuk. The helicopter that we're using is a cheap (26$) 3-channel (yaw, throttle, pitch) helicopter that I bought a 1 month back from Dealextreme.com . I can say that it is a VERY durable heli : I have crashed more thant 100 times and it's still working ! It is not radio-controlled ...
I just hope every body's heard. The Bird is the Word! This is a simple device to play Surfin Bird really loudly when someone trips off the motion sensor. If you don |
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342
] | ations and used them to debunk the whole notion of a yeti.
Annoyed but undeterred, Slick turned his attentions to another reported man-ape creature, this one said to be living deep in the woods of the Pacific Northwest: Sasquatch, often referred to as Bigfoot.
That we know anything at all about Tom Slick's search for the yeti and Bigfoot is due almost entirely to Coleman's efforts. A cryptozoologist himself, Coleman spent the better part of thirty years researching Tom Slick's life, particularly as it related to his contributions to cryptozoology. The result was his 1989 book _Tom Slick and the Search for the Yeti_.
Coleman wrote in the introduction to his book: "This man would throw his fortune behind a serious search for the mysterious creatures. Who was this man? He was a handsome, lean, prematurely white-haired man, soft spoken, with a slight Southern drawl. Tom Slick was his name, more fictional-sounding than real. And in many ways, Tom Slick's life was the stuff legends are made of...Tom Slick was given many names during his short, event-filled life. But today, hardly anyone remembers him. And that's a shame."
Like his father, Slick died when he was forty-six. A plane he was riding in exploded over Montana in 1962. Had he lived, Tom Slick might have hooked up with or even founded the Texas Bigfoot Research Conservancy, which carries on Slick's interests in Texas. The Texas Bigfoot is believed to be a southern cousin of the Pacific Northwest's Sasquatch. Of the one hundred or so sightings reported on the center's website, the center deems about seventy-five of those sightings as legitimate in the way that sightings of unidentified flying objects are legitimate; both remain unidentified. Persistent reports of a Sasquatch-like creature living along the Sulphur River, just across the state line in Arkansas, inspired the movie _Legend of Boggy Creek._
The modern-day Texas Bigfoots (Bigfeet?) go by many names, some of which sound like high-end fishing lures: Night Screamer, Hawley Him, Haskell Rascal, Wooly Bugger and Caddo Critter. The people at the Texas Bigfoot Research Conservancy believe that the sightings indicate a primate, albeit an elusive one for which no remains have ever been positively identified. Recent sightings have occurred in the Sam Houston National Forest, near the San Jacinto River. We might say that all of this started with Tom Slick, but to call him Texas's first cryptozoologist we would have to dismiss the Comanches, Tonkawas and other Texas tribes who believed strongly in a man-ape creature in the same way that they believed in, say, bears.
The Hill Country has had a few sightings, too. One came in 1902 in a cedar chopper community called Panther Path in Travis County. A group of young people were fishing and hunting in the area above the old McDonald Dam when a hairy, eight-foot-tall man confronted the young sportsmen with a large club, the better to pulverize them. Bigfoot let loose a bloodcurdling scream and advanced in what can only be described as a menacing manner toward the terrified young people. They ran for the wagons and barely made it. Bigfoot followed them for a while before giving up and disappearing into legend and lore. Bigfoot was the target of many a Hill Country hunter for a while after that, but neither hide nor hair was seen of the creature again. If only Tom Sick and his team had been there!
But I may be doing Tom Slick an injustice to focus solely on his searches for abominable snowmen, Bigfoot and several other perhaps mythical creatures. This was a man who founded what is today the Southwest Foundation for Biomedical Research, the Institute of Inventive Research, the Southwest Research Institute and the Mind Science Foundation. Much of the work he founded continues today.
Slick helped develop Brangus cattle and at one time had one of the three largest herds of Angus cattle in the country. Following in the footsteps of his wildcatter father, he discovered the Benedum Field in west Texas, one of the largest oil strikes in the United States after World War II.
Most of us don't have any reasonable expectation of having Tom Slick's resources or of leaving such a legacy. What most of us have in common with Tom Slick is that we, too, want to know, once and for all, if there is or ever was such a creature as the yeti or Bigfoot. Like Tom Slick, we just want to know.
### THE PLIGHT OF THE PLEUROCOELEUS
We don't usually think of dinosaurs when we think of Texas. We might think about the state's officially designated large mammal, the longhorn, or the state small mammal, the armadillo. We know that the state bird is the mockingbird, the state tree is the pecan and the horned lizard (or horny toad, as most of us call it) is the state reptile. Rock hounds might even know that the state stone is petrified palm wood. Seldom is heard a word, discouraging or otherwise, about the state dinosaur, the pleurocoeleus.
The pleurocoeleus is the official state dinosaur of Texas.
Whether Texas actually needs a state dinosaur is open to debate, but the pleurocoeleus ( _Brachiosaur sauropod_ ) was so designated by the state legislature 1997. It's our dinosaur, by golly, and we're Texans, so we're going to be proud of it, even if it wasn't what you might call ferocious. You might think that Texas would have adopted a carnivore, but our dinosaur was a strict vegetarian. At least it was big—about fifty feet long and weighing in at about twenty tons. Paleontologists tell us that despite its size, our dinosaur was decidedly mild-mannered. Fight or flight? The pleurocoeleus probably didn't have to give the matter a lot of thought.
We can watch and listen to mockingbirds, pick pecans and we know a longhorn cow when we see one and an armadillo, which we can't always avoid when they try to cross the road. The pleurocoeleus hasn't been seen in these parts for, oh, about sixty-five million years, give or take a few million years either way. But we have proof that they lived here.
Near Glen Rose, at the appropriately named Dinosaur Valley State Park, on the banks of the Paluxy River and in the riverbed itself, are some remarkably well-preserved pleurocoeleus tracks. These are some of the best dinosaur tracks in the world, which is why paleontologists love the park and have ever since Roland T. Bird of the American Museum of Natural History visited the site in 1938. Bird realized that a set of double tracks showed an herbivorous sauropod—most likely our boy, the pleurocoeleus—being chased by a meat-eating carnosaur.
This was the first time sauropod tracks had been discovered anywhere in the world, which caused no small amount of excitement back in New York. The Glen Rose tracks were duly sent to New York and displayed at the American Museum of Natural History. The pleurocoeleus obviously couldn't get away from the site fast enough on that particular day, but since then its tracks have been scattered hither and yon, to the Texas Memorial Museum in Austin and, unfortunately, into the private residences of many amateurs—or vandals, depending on how you look at these things.
The dinosaur tracks are a major wonder, but it's a small wonder that any tracks are left here at all. People complain that all the "good" tracks have been removed from the Paluxy River Valley. A woman in Glen Rose told me that a lot of area families have a quarried dinosaur track or two in their homes. "You usually see them on people's living room wall," she said.
It took a special set of circumstances to preserve the tracks for all these millions of years. Scientists believe that a violent storm blew across the shoreline a few days before the tracks were made and created a series of sand- and lime-laden mudflats. A herd of pleurocoeleus came ambling across the sticky and still-wet mud in search of a primordial salad, followed in interested pursuit by the carnosaurs looking for some fresh sauropods; the pleurocoeleus qualified.
True to their pacifistic nature, the pleurocoeleus tried to run away, but we don't know if they won that particular footrace or not. No intact skeleton remains were ever found, just huge saucerlike depressions from their hind feet and smaller tracks, much like horseshoes, from their front legs.
The primal, existential struggle for food and survival was preserved in stone when the seashore turned to stone, leaving behind the rocks we see in the park today, including the ones with the dinosaur prints.
We in Texas have never collected dinosaur fossils like we have collected, say, arrowheads, but the state has had its fair share of fossilized dinosaur discoveries over the years due to a quirk of ancient geography dating back to when much of what is now Texas was covered by an ancient sea. As the sea level rose, the land was covered with |
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] | + s. Round a to the nearest 100000.
600000
Let s = -0.2247 + -13.0613. Let u = -11.17 - s. What is u rounded to one dp?
2.1
Let q = 114.8 + -39.1. Let x = -71.995 + q. What is x rounded to one decimal place?
3.7
Let y(p) = -14*p + 0*p + p**3 + 12*p + 5*p**2 + 76100. Let u be y(0). Round u to the nearest 1000.
76000
Let t = 11577 - 7808.5. What is t rounded to the nearest one hundred?
3800
Let h = -1131604 + 1771264. Round h to the nearest one hundred thousand.
600000
Let l = 226 + -212. Let r = 2564.79546 + -2550.7954531. Let y = l - r. Round y to 6 dps.
-0.000007
Suppose 2*u + 16 = 4*q, 9*u = 4*q + 5*u - 20. Suppose -q*i + t = 9244, -3*i - 7777 = 4*t + 1447. Round i to the nearest 1000.
-3000
Let x = 29 + -24. Suppose x*p = -3*n + 30220, n = 3*n - 4*p - 20154. Suppose -10*z + 4625 = -n. What is z rounded to the nearest 100?
1500
Let m = 4257 - 4260.4394. Let c = 3.49 + m. What is c rounded to 3 dps?
0.051
Let i be -5 + -1 - (-38 - 146741748)/31. What is i rounded to the nearest one hundred thousand?
4700000
Let u = 221.4200040101 - 221.42. What is u rounded to 6 dps?
0.000004
Let k = 283 - 388. Let a = k - -105.093. What is a rounded to 2 decimal places?
0.09
Let v = -8291.9997759 + 8292. What is v rounded to 5 dps?
0.00022
Let z = -62 + 71. Suppose z*d - 14*d = 321500. What is d rounded to the nearest one thousand?
-64000
Suppose 78*q - 8 = 74*q. Suppose q*l - 292114 = -f + 226886, -5*l = -f + 519000. What is f rounded to the nearest ten thousand?
520000
Let y be 2228/(-10) + (-1)/5. Let d = -81 + 168. Let k = y - d. Round k to the nearest 100.
-300
Let i = -17 + 47. Let c = i + -1. Let a = -28 + c. Round a to 0 decimal places.
1
Suppose -109*w - 36075994 = -5*l - 106*w, -4*w = l - 7215208. Round l to the nearest 10000.
7220000
Let x = -0.05302 + -3.02998. Let z = 17.75 Edward Smith, aged 63, a self-described mechaphile, said he has held intense sexual feelings for automobiles since he was 14. "I feel a tremendous sense of calm when I am with her," Smith explained. "No matter how I tell people they are blown away. 'What's he do just stick it up the tail pipe?' That's all they can think of and the sexual satisfaction it's not like that. It's so much more. It's about making a connection with this car's spiritual energy. I've been with Vanilla for 30 years now. I still get the temptation to pull over the side of the road if I see a really cute car parked. But I don't want to break my promise to Vanilla to remain faithful to her."1. Field of the Invention
The present invention relates to methods for the mechanochemical preparation of stable passivated nanoparticles, made of e.g. silicon or germanium.
2. General Background of the Invention
A nanoparticle (or nanopowder) is a microscopic particle with at least one dimension less than 100 nanometer (nm). Nanoparticles have recently been at the forefront of biomedical, optical, and electronics research because they can exhibit fundamentally new behavior when their sizes fall below the critical length scale associated with any given property. A bulk material is generally considered to have uniform physical properties throughout regardless of its size, but at the nano-scale the properties of materials change as the percentage of atoms at the surface of the material becomes significant. Below the micrometer scale, size-dependent properties are observed such as quantum confinement in semiconductor particles, surface plasmon resonance in some metal particles, and supermagnetism in magnetic materials.
Quantum confinement occurs when electrons and holes in a semiconductor are restricted in one or more dimensions. A quantum dot is confined in all three dimensions, a quantum wire is confined in two dimensions, and a quantum well is confined in one dimension. That is, quantum confinement occurs when one or more of the dimensions of a nanocrystal is made very small so that it approaches the size of an exciton in bulk crystal, called the Bohr exciton radius. An exciton is a bound state of an electron and an imaginary particle called an electron hole in an insulator or semiconductor. An exciton is an elementary excitation, or a quasiparticle of a solid. A quantum dot is a structure where all dimensions are near the Bohr exciton radius, typically a small sphere. A quantum wire is a structure where the height and breadth is made small while the length can be long. A quantum well is a structure where the height is approximately the Bohr exciton radius while the length and breadth can be large. Quantum confinement effects at very small crystalline sizes can cause silicon and germanium nanoparticles to fluoresce, and such fluorescent silicon and germanium nanoparticles have great potential for use in optical and electronic systems as well as biological applications.
Silicon and germanium nanoparticles may be used, e.g., in optical switching devices, photovoltaic cells, light emitting diodes, lasers, and optical frequency doublers, and as biological markers.
The photoluminescence (PL) mechanism in silicon and germanium nanoparticles is also influenced by the nature and bonding state of the particle surface. Photoluminescence is a process in which a chemical compound absorbs photons (electromagnetic radiation), thus transitioning to a higher electronic energy state, and then radiates photons back out, returning to a lower energy state. The period between absorption and emission is typically extremely short, on the order of 10 nanoseconds. Under special circumstances, however, this period can be extended into minutes or hours. Ultimately, available chemical energy states and allowed transitions between states (and therefore wavelengths of light preferentially absorbed and emitted) are determined by the rules of quantum mechanics. A basic understanding of the principles involved can be gained by studying the electron configurations and molecular orbitals of simple atoms and molecules. More complicated molecules and advanced subtleties are treated in the field of computational chemistry.
Light absorption and emission in a semiconductor are known to be heavily dependent on the detailed band structure of the semiconductor. Direct band gap semiconductors are semiconductors for which the minimum of the conduction band occurs at the same wave vector, k, as the maximum of the valence band. Direct band gap semiconductors have a stronger absorption of light as characterized by a larger absorption coefficient and are also the favored semiconductors when fabricating light emitting devices. Indirect band gap semiconductors are semiconductors for which the minimum of the conduction band does not occur at the same wave vector as the maximum of the valence band. Indirect band gap semiconductors are known to have a smaller absorption coefficient and are rarely used in light emitting devices.
This striking difference between direct band gap semiconductors and indirect band gap semiconductors can be explained by the energy and momentum conservation required in the electron-photon interaction. The direct band gap semiconductor has a vertically aligned conduction and valence band. Absorption of a photon is obtained if an empty state in the conduction band is available for which the energy and momentum equals that of an electron in the valence band plus that of the incident photon. Photons have little momentum relative to their energy since they travel at the speed of light. The electron therefore makes an almost vertical transition on the E-k diagram. For an indirect band gap semiconductor, the conduction band is not vertically aligned to the valence. Therefore a simple interaction of an incident photon with an electron in the valence band will not provide the correct energy and momentum corresponding to that of an empty state in the conduction band. As a result absorption of light requires the help of another particle, namely a phonon.
A phonon is a particle associated with lattice vibrations and has a relatively low velocity close to the speed of sound in the material. Phonons have a small energy and large momentum compared to that of photons. Conservation of both energy and momentum can therefore be obtained in the absorption process if a phonon is created or an existing phonon participates. The minimum photon energy that can be absorbed is slightly below the band gap energy in the case of phonon absorption and has to be slightly above the band gap energy in the case of phonon emission. Since the absorption process in an indirect band gap semiconductor involves a phonon in addition to the electron and photon, the probability of having an interaction take place involving all three particles will be lower than a simple electron-photon interaction in a direct band gap semiconductor. As a result one finds that absorption is much stronger |
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] | serious expression turned decidedly less so. "If I'm not mistaken, Roland, I believe you just said I was . . . over the hill."
Reacting to the spark of playfulness in her features, he laughed. "If you're over the hill, Lizzie, then I've already got one foot in the grave." He looked down at his legs. "Oh wait . . ."
He laughed. But she only smiled and eyed him.
"I'm so very grateful you lived." Her eyes lit with a sparkle that precious stones would envy. "And that you got to keep your leg."
"And that, my dear Lizzie—" On impulse, Roland reached out his hand, much as he might have done if he were attempting to stroke a skittish doe. And to his surprise, she met him halfway. "That is completely due to you keeping your promise. For which I will forever be grateful."
He gently tightened his hand around hers, and the light in her eyes deepened. But too quickly for him, she pulled her hand away. And he reminded himself again, _Friendship. Only friendship._
She reached into her pocket and pulled something out. A thin bundle of letters, he saw upon closer inspection, tied with string.
"I'd like to show you something," she said. "And get your opinion, if I could."
"Letters from a secret admirer?" he asked, forcing humor into his voice.
"No," she whispered, not looking up. "These belonged to a soldier who was here at Carnton. A boy. He was no more than thirteen or fourteen years old." She handed them to him.
Sobered, he turned the thin bundle in his hand. "There's no address."
"I know. So I have no idea where to send them. Or if Thaddeus wrote them. Or if they were written to him."
"Thaddeus?"
"I found the name written on a page torn from a Bible. It was with the envelopes in his pocket. But there was no last name. I asked Colonel McGavock this morning if he would check with the War Department to see if they could look up his first name to learn his last. He said he would contact them for me. But look at the string, Roland. It's tied in a knot. Who knots a stack of letters they intend to read again? And for some reason, I can't bring myself to cut it. It feels wrong somehow. Like I'm trespassing. Or maybe there's something in there I shouldn't be privy to."
He smiled at her. "Now you sound like a character from a mystery novel. I seriously doubt there's anything a boy that age would commit to paper, much less carry around with him, that would be too unseemly."
She leaned forward. "There's something else. It's what he said to me at the very last, right before he died."
"Now you really are sounding mysterious."
She briefly closed her eyes. "He said, 'Mama' . . . I think he must've thought he was speaking to her. He said he'd grieved over how he'd left things between them, but that he didn't take it with him like he'd apparently told her he had."
"He didn't take what?"
She shrugged. "That's just it. I don't know. He didn't say. But whatever it is, or was, he said he left it there, buried beneath 'the old willow tree.' And then, right before he died, he whispered, 'Somehow it makes dying easier, knowing you'll have it.'"
Roland said nothing for a moment, then sighed. "Well, that certainly sheds an interesting light on things, doesn't it?"
She nodded, staring at the bundle in his hands. "I think that's why I haven't been able to read these. I feel such a . . ."
"Burden?" he supplied.
"Yes. And also a responsibility. But the fact that the string is knotted tight . . ." She eyed it as though it were a living thing. "It doesn't make sense, I know."
"Do you think maybe one of the doctors gave the boy some medication that caused him to become delusional? Maybe he was speaking nonsense."
She shook her head. "The doctors weren't administering medicine to anyone who didn't stand a good chance of living. And he did not."
What she said about medication not being administered haphazardly was true. They hadn't even offered him any, until Dr. Phillips ordered it.
She looked down at her hands in her lap. "All I know, Roland, is that I can't cut the string. But . . ." She slowly lifted her gaze. "Maybe you could."
He raised his brows. "So let me get this straight. You want me to cut the string and open the envelopes so that whatever curse you apparently believe is going to befall the poor, unsuspecting soul who does such will settle on me instead of you. Is that what I'm to understand?"
The tiniest smile crept over her face, and she nodded. "Yes. That's pretty much the gist of it."
He eyed her for a moment, then gestured. "Hand me that knife on the table over there."
**C HAPTER 19**
Roland sliced through the knotted string binding the stack of envelopes, sensing Lizzie's trepidation. But being a soldier himself, and carrying his own bundle of letters, he felt at ease with what he was doing. He withdrew the contents of the first of three envelopes and began to read. The handwriting was rather slapdash, so the words were difficult to decipher.
"What?" Lizzie whispered, leaning closer. "You're frowning. What is it?"
Hearing her increased concern, he couldn't resist egging her on a bit. "Mmmm . . . Lizzie, this is bad."
She reached out. "What does it say?"
Her hand on his bare arm sent a small thunderbolt through him. It took concentration to continue reading. "It says . . . 'Hayrides. Walks by the creek. Warm biscuits on Sunday mornings. The smell of snow. Melvin, when he burrows down deep beneath the covers with me.'" He lifted his gaze and caught her droll look. "It's some sort of list."
Smiling, he scanned the wrinkled, stained piece of paper, then turned it over. The handwriting filled both front and back. He handed it to her, and she read silently, her lips moving. Softness swept her face.
"I think it's a list of things he loved." She fingered a dog-eared corner, her tone almost reverent.
"Sunsets painted orangey red. A fresh ticked bed and a warm blanket. The feel of mud between your toes come summer. Rain as it sluices off the metal roofing. Mist as it hangs over the hills."
Roland loved watching her. She possessed a kind of beauty that only seemed to deepen the more he got to know her. Features he'd thought comely upon first glance—her full lips, the slight up-tilt of her pretty nose, the womanly curves that not even the simplest blue day dress could mask—he now found intoxicating. She finally folded the letter, and he held up the other two envelopes.
"Should we?" he asked.
She nodded, but made no move to take them.
"Since I'm the one already cursed . . . ," he said beneath his breath, satisfied when the comment drew a soft laugh.
He opened the second envelope and withdrew a piece of paper similar in appearance to the first, with the same scrawled handwriting. "This one says . . ." Tempted to tease her again, he read the first few lines and all humor fell away. He cleared his throat.
"You were right, Mama. This undertaking of mine is far more egregious than my thoughts ever could have conjured. I am not as brave as I once thought myself to be. Before battle commences, in those eternally fleeting moments before the first shot is fired, my bones all but shake free from their joints, and I do not know how my body holds together. I am thoroughly run through with fear. And I am ashamed of being afraid. But I am not the only one. I have seen grown men . . ."
He stopped reading aloud. Not that Lizzie would have been offended by the boy's description. He'd witnessed firsthand all she'd been through since the battle that night, and he was convinced there was nothing this woman couldn't endure with grace and dignity. Rather, he'd witnessed the same things the boy was describing and it had moved him just as deeply.
She gently tugged the pages from his hand. "'I have seen grown men,'" she continued, her voice a whisper, "'lose the contents of their stomachs, and worse, as the first blast of a Napoleon gun sends a cannonball screaming for the front line. Some men are very shaky. Often they take off running the other way. I have seen more than one officer use his revolver on his own men as they seek to retreat before the battle is fully begun.'"
She drew in a slow, painstaking breath, and Roland reached for the pages. But |
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1572,
3799
] | a system composed of $N$ distinguishable particles arranged in a chain, each of the particles in the chain is characterized by a binary random variable (this can be, for example, particles with the spin $\frac{1}{2}$). In the aforementioned model it is assumed that spins next to each other are almost always aligned in the same direction. The only exceptions are assumed to be $d$ cases in which the neighboring spins are antialigned. In this model the number of states grows as a power-law, with the corresponding index $q$ being $q_{\mathrm{stat}}=1-1/d$. In addition, the distribution of the total spin of the system in the limit of $N\rightarrow\infty$ tends to a $q$-Gaussian with $q_{\mathrm{dist}}\neq
q_{\mathrm{stat}}$. All models in [@Moyano2006; @Rodriguez2008; @Ruseckas2015], except the last model of [@Rodriguez2008] are for $q\leq1$.
The distributions of the non-extensive statistical mechanics can be obtained from mesoscopic description of the systems in the form of probabilistic dynamics [@Tsallis2009-1]. Such probabilistic description can be provided by nonlinear Fokker-Planck equations and corresponding nonlinear stochastic differential equations (SDEs) [@Borland1998; @Borland2002], SDEs with additive and multiplicative noises [@Anteneodo2003; @Santos2010] or with multiplicative noise only [@Queiros2007], and with fluctuating friction forces [@Beck2001]. Nonlinear SDEs generating distributions of non-extensive statistical mechanics together with $1/f$ noise have been proposed in Ref. [@Ruseckas2011]. Scaling law that follows from nonlinear Fokker-Planck equations has been recently experimentally confirmed in granular media [@Combe2015].
The goal of this paper is to extend the model presented in Ref. [@Ruseckas2015] by introducing stochastic temporal dynamics. Conserving the total number of domains $d$, we allow spins near domain boundaries to flip. This effectively introduces a random walk of domain boundaries into the previous static model. In the limit of large number of spins we derive the Fokker-Planck equation and a corresponding SDE describing the temporal dynamics of the total spin of the system. The proposed dynamical model provides an insight how a mesoscopic dynamics characterized by the non-extensive statistical mechanics could emerge from a microscopic description of the system.
The Letter is organized as follows. To show how stochastic temporal dynamics can be introduced into a model describing the equilibrium, in Section \[sec:uncorrelated\] we introduce stochastic dynamics into a simple model consisting of uncorrelated binary random variables. In Section \[sec:correlated\] we use a similar stochastic temporal dynamics for the model with correlated binary random variables and leading to extensive generalized entropy with $q<1$. In Section \[sec:long-range\] we demonstrate that presence of macroscopic fluctuations in this model can lead to $1/f$ noise, whereas in Section \[sec:subsyst\] we consider properties of a part of larger system. We summarize the paper in Section \[sec:conclusions\].
Stochastic dynamics in the model with uncorrelated binary variables {#sec:uncorrelated}
===================================================================
As in Ref. [@Ruseckas2015], we start with the analysis of the dynamical model without any correlations between the particles or their spins. Let us say that we have $N$ particles which have spin projections on certain axis equal to either $-\frac{1}{2}$ or $+\frac{1}{2}$. The microscopic state of such system is fully described by a set of spin projections $\{s_{1},s_{2},\ldots,s_{N}\}$. This system may be treated, in the statistical mechanics sense, using the microcanonical ensemble in which each of the microscopic states is assigned the same probability. Here we obtain the same stationary probability density function (PDF) from the temporal dynamics perspective.
We are interested in an observable macroscopic quantity, the total spin of the system $$M=\sum_{i=1}^{N}s_{i}\,.\label{eq:total-spin}$$ Alternatively we can express the total spin as $$M=\frac{1}{2}(N_{+}-N_{-})\,,\label{eq:m-np-nm}$$ where $N_{+}$ is the number of spins with projection $+\frac{1}{2}$ and $N_{-}$ is the number of spins with projection $-\frac{1}{2}$. A sum of $N_{+}$ and $N_{-}$, by definition, should give the total number of spins $N$, $$N_{+}+N_{-}=N\,.\label{eq:n-np-nm}$$ From Eqs. (\[eq:m-np-nm\]) and (\[eq:n-np-nm\]) we obtain relation between total spin and number of particles having certain spin projections: $$N_{+}=\frac{1}{2}N+M\,,\qquad N_{-}=\frac{1}{2}N-M\,.\label{eq:np-nm}$$
To introduce temporal dynamics we assume that during the short time interval $\Delta t$ each spin can flip with the probability $\frac{1}{2}\gamma\Delta t$. If $\Delta t$ is short enough we can assume that only one spin flip takes place during the time interval $\Delta t$. Since each spin can flip independently, the transition probabilities per unit time are $$\begin{aligned}
p(M\rightarrow M+1) & \equiv & p^{+}(M)=\frac{1}{2}\gamma N_{-}\,,
\label{eq:prob-p}\\
p(M\rightarrow M-1) & \equiv & p^{-}(M)=\frac{1}{2}\gamma N_{+}\,.
\label{eq:prob-m}\end{aligned}$$ The transition probabilities $p^{+}(M)$ and $p^{-}(M)$ define a one-step stochastic process and imply the following Master equation for the probability $P_{M}(M,t)$ to find the value $M$ of the total spin at time $t$ [@Kampen2011]: $$\frac{\partial}{\partial t}P_{M}(M,t)=p^{+}(M-1)P_{M}(M-1,t)
+p^{-}(M+1)P_{M}(M+1,t)-(p^{+}(M)+p^{-}(M))P_{M}(M,t)\,.
\label{eq:master}$$ For large enough $N$ we can represent the dynamics by a continuous variable $x=2M/N$. Using the standard methods from Ref. [@Kampen2011] one can derive the Fokker-Planck equation from the Master equation (\[eq:master\]) assuming that $N$ is large and neglecting the terms of the order of $1/N^{2}$. The resulting Fokker-Planck equation is $$\frac{\partial}{\partial t}P_{x}(x,t)=-\frac{\partial}{\partial x}
[\pi^{+}(x)-\pi^{-}(x)]P_{x}(x,t)
+\frac{\partial^{2}}{\partial x^{2}}\frac{1}{N}[\pi^{+}(x)+\pi^{-}(x)]P_{x}(x,t)\,,
\label{eq:FP-general}$$ where $P_{x}(x,t)=(N/2)P_{M}(Nx/2,t)$ is the PDF of the stochastic variable $x$ and $$\pi^{\pm}(x)\equiv\frac{2}{N}p^{\pm}\left(\frac{Nx}{2}\right)\,.$$ The SDE corresponding to the Fokker-Planck equation (\[eq:FP-general\]) is [@Gardiner2009] $$\frac{dx}{dt}=[\pi^{+}(x)-\pi^{-}(x)]+\sqrt{\frac{2}{N}[\pi^{+}(x)+\pi^{-}(x)]}\xi(t)\,.
\label{eq:SDE-general}$$ Here $\xi(t)$ is a white noise with autocorrelation $\langle\xi(t)\xi(t')\rangle=\delta(t-t')$. When the diffusion coefficient depends on $x$, SDE (\[eq:SDE-general\]) should be understood in Itô convention.
For the transition probabilities (\[eq:prob-p\]) and (\[eq:prob-m\]), the Fokker-Planck equation (\[eq:FP-general\]) becomes $$\frac{\partial}{\partial t}P_{x}(x,t)=\gamma\frac{\partial}{\partial x}xP_{x}(x,t)
+\frac{\gamma}{N}\frac{\partial^{2}}{\partial x^{2}}P_{x}(x,t)
\label{eq:FP-1}$$ and Eq. (\[eq:SDE-general\]) takes the form $$\frac{dx}{dt}=-\gamma x+\sqrt{\frac{2\gamma}{N}}\xi(t)\,.\label{eq:sde-1}$$ As one can see from Eq. (\[eq:sde-1\]), the fluctuations of the macroscopic quantity $M$ decrease with the increasing number of spins as $1/\sqrt{N}$ . From Eq. (\[eq:sde-1\]) follows that the average value of $x$ obeys the ordinary differential equation $$\frac{d}{dt}\langle x\rangle=-\gamma\langle x\rangle\,.$$ Thus the deviations from the equilibrium average $\langle x\rangle_{0}=0$ decay exponentially: $\langle x(t)\rangle |
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] | Pine section, developed the pine biscuit recipe, and updated information and added citations throughout.#!/bin/sh
#
# builddeb 1.3
# Copyright 2003 Wichert Akkerman <[email protected]>
#
# Simple script to generate a deb package for a Linux kernel. All the
# complexity of what to do with a kernel after it is installed or removed
# is left to other scripts and packages: they can install scripts in the
# /etc/kernel/{pre,post}{inst,rm}.d/ directories (or an alternative location
# specified in KDEB_HOOKDIR) that will be called on package install and
# removal.
set -e
is_enabled() {
grep -q "^$1=y" include/config/auto.conf
}
if_enabled_echo() {
if is_enabled "$1"; then
echo -n "$2"
elif [ $# -ge 3 ]; then
echo -n "$3"
fi
}
create_package() {
local pname="$1" pdir="$2"
mkdir -m 755 -p "$pdir/DEBIAN"
mkdir -p "$pdir/usr/share/doc/$pname"
cp debian/copyright "$pdir/usr/share/doc/$pname/"
cp debian/changelog "$pdir/usr/share/doc/$pname/changelog.Debian"
gzip -9 "$pdir/usr/share/doc/$pname/changelog.Debian"
sh -c "cd '$pdir'; find . -type f ! -path './DEBIAN/*' -printf '%P\0' \
| xargs -r0 md5sum > DEBIAN/md5sums"
# Fix ownership and permissions
chown -R root:root "$pdir"
chmod -R go-w "$pdir"
# in case we are in a restrictive umask environment like 0077
chmod -R a+rX "$pdir"
# Create the package
dpkg-gencontrol -p$pname -P"$pdir"
dpkg-deb ${KDEB_COMPRESS:+-Z$KDEB_COMPRESS} --build "$pdir" ..
}
deploy_kernel_headers () {
pdir=$1
rm -rf $pdir
(
cd $srctree
find . arch/$SRCARCH -maxdepth 1 -name Makefile\*
find include scripts -type f -o -type l
find arch/$SRCARCH -name module.lds -o -name Kbuild.platforms -o -name Platform
find $(find arch/$SRCARCH -name include -o -name scripts -type d) -type f
) > debian/hdrsrcfiles
{
if is_enabled CONFIG_STACK_VALIDATION; then
echo tools/objtool/objtool
fi
find arch/$SRCARCH/include Module.symvers include scripts -type f
if is_enabled CONFIG_GCC_PLUGINS; then
find scripts/gcc-plugins -name \*.so
fi
} > debian/hdrobjfiles
destdir=$pdir/usr/src/linux-headers-$version
mkdir -p $destdir
tar -c -f - -C $srctree -T debian/hdrsrcfiles | tar -xf - -C $destdir
tar -c -f - -T debian/hdrobjfiles | tar -xf - -C $destdir
rm -f debian/hdrsrcfiles debian/hdrobjfiles
# copy .config manually to be where it's expected to be
cp $KCONFIG_CONFIG $destdir/.config
mkdir -p $pdir/lib/modules/$version/
ln -s /usr/src/linux-headers-$version $pdir/lib/modules/$version/build
}
deploy_libc_headers () {
pdir=$1
rm -rf $pdir
$MAKE -f $srctree/Makefile headers
$MAKE -f $srctree/Makefile headers_install INSTALL_HDR_PATH=$pdir/usr
# move asm headers to /usr/include/<libc-machine>/asm to match the structure
# used by Debian-based distros (to support multi-arch)
host_arch=$(dpkg-architecture -a$(cat debian/arch) -qDEB_HOST_MULTIARCH)
mkdir $pdir/usr/include/$host_arch
mv $pdir/usr/include/asm $pdir/usr/include/$host_arch/
}
version=$KERNELRELEASE
tmpdir=debian/linux-image
dbg_dir=debian/linux-image-dbg
packagename=linux-image-$version
dbg_packagename=$packagename-dbg
if [ "$ARCH" = "um" ] ; then
packagename=user-mode-linux-$version
fi
# Not all arches have the same installed path in debian
# XXX: have each arch Makefile export a variable of the canonical image install
# path instead
case $ARCH in
um)
installed_image_path="usr/bin/linux-$version"
;;
parisc|mips|powerpc)
installed_image_path="boot/vmlinux-$version"
;;
*)
installed_image_path="boot/vmlinuz-$version"
esac
BUILD_DEBUG=$(if_enabled_echo CONFIG_DEBUG_INFO Yes)
# Setup the directory structure
rm -rf "$tmpdir" "$dbg_dir" debian/files
mkdir -m 755 -p "$tmpdir/DEBIAN"
mkdir -p "$tmpdir/lib" "$tmpdir/boot"
# Install the kernel
if [ "$ARCH" = "um" ] ; then
mkdir -p "$tmpdir/usr/lib/uml/modules/$version" "$tmpdir/usr/bin" "$tmpdir/usr/share/doc/$packagename"
cp System.map "$tmpdir/usr/lib/uml/modules/$version/System.map"
cp $KCONFIG_CONFIG "$tmpdir/usr/share/doc/$packagename/config"
gzip "$tmpdir/usr/share/doc/$packagename/config"
else
cp System.map "$tmpdir/boot/System.map-$version"
cp $KCONFIG_CONFIG "$tmpdir/boot/config-$version"
fi
cp "$($MAKE -s -f $srctree/Makefile image_name)" "$tmpdir/$installed_image_path"
if is_enabled CONFIG_OF_EARLY_FLATTREE; then
# Only some architectures with OF support have this target
if [ -d "${srctree}/arch/$SRCARCH/boot/dts" ]; then
$MAKE -f $srctree/Makefile INSTALL_DTBS_PATH="$tmpdir/usr/lib/$packagename" dtbs_install
fi
fi
if is_enabled CONFIG_MODULES; then
INSTALL_MOD_PATH="$tmpdir" $MAKE -f $srctree/Makefile modules_install
rm -f "$tmpdir/lib/modules/$version/build"
rm -f "$tmpdir/lib/modules/$version/source"
if [ "$ARCH" = "um" ] ; then
mv "$tmpdir/lib/modules/$version"/* "$tmpdir/usr/lib/uml/modules/$version/"
rmdir "$tmpdir/lib/modules/$version"
fi
if [ -n "$BUILD_DEBUG" ] ; then
for module in $(find $tmpdir/lib/modules/ -name *.ko -printf '%P\n'); do
module=lib/modules/$module
mkdir -p $(dirname $dbg_dir/usr/lib/debug/$module)
# only keep debug symbols in the debug file
$OBJCOPY --only-keep-debug $tmpdir/$module $dbg_dir/usr/lib/debug/$module
# strip original module from debug symbols
$OBJCOPY --strip-debug $tmpdir/$module
# then add a link to those
$OBJCOPY --add-gnu-debuglink=$dbg_dir/usr/lib/debug/$module $tmpdir/$module
done
# resign stripped modules
if is_enabled CONFIG_MODULE_SIG_ALL; then
INSTALL_MOD_PATH="$tmpdir" $MAKE -f $srctree/Makefile modules_sign
fi
fi
fi
# Install the maintainer scripts
# Note: hook scripts under /etc/kernel are also executed by official Debian
# kernel packages, as well as kernel packages built |
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] | . Let w(x) be the second derivative of x**3/3 + x. What is w(v(u))?
2*u
Let c(l) = -4*l. Let v(q) = 15*q + 2. Calculate v(c(z)).
-60*z + 2
Let a(i) be the first derivative of 0*i + 0*i**2 - 3 - 1/3*i**3. Let g(x) = 2*x**2. Calculate g(a(s)).
2*s**4
Let u = 10 + -8. Let m(z) = 0 + 0 + z**u. Let t(f) = f**2 - f - 1. Let o(l) = l + 1. Let k(n) = 3*o(n) + 3*t(n). Determine k(m(g)).
3*g**4
Let m(i) = -63*i - 4. Let k(g) = 2*g. Calculate m(k(r)).
-126*r - 4
Let d(x) be the first derivative of -8*x**Janus TiXY Monolayers with Tunable Berry Curvature.
Up to now, two-dimensional (2D) materials with both valley polarization and the Rashba effect are still rare. In this work, a new kind of Janus monolayers TiXY (X ≠ Y, X/Y = Cl, Br, I) is demonstrated to have physical properties of benefit for spintronics and valleytronics. In particular, Janus TiBrI shows Zeeman-type spin splitting of 70 meV, large Berry curvature of 106.22 bohr2, and, at the same time, a large Rashba parameter of 147.95 meV Å. On the basis of k·p perturbation theory, we proposed that the Berry curvature can be adjusted by changing the lattice parameter, which will greatly improve the transverse velocities of carriers and promote the efficiency of the valley Hall device. Biaxial strain from -2.5 to 2.5% was applied on Janus TiBrI to verify the theory mentioned above, and a general relationship between the Berry curvature and lattice constant was obtained.Antileukotoxin antibody produced in the bovine lung after aerosol exposure to viable Pasteurella haemolytica.
Experiments were performed to determine the in vivo immunogenicity of Pasteurella haemolytica leukotoxin. Calves were exposed twice to aerosol mists of viable P haemolytica, using a treatment regimen previously shown to induce a resistant state. Pulmonary lavage fluids and serum samples from these calves were assayed for leukotoxin-neutralizing antibodies. Before aerosol exposure, neutralizing antibody titers were routinely found in serum samples, but were not detectable in pulmonary lavage concentrates before exposure. After aerosol exposure, titers of toxin-neutralizing immunoglobulin (Ig)A and IgG antibodies were found in pulmonary lavage concentrates and were accompanied by increased serum toxin neutralization titers.Bluemindo
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using GSTreamer 1.x and GTK 3.x.1. Introduction {#sec1}
===============
The face of the HIV/AIDS epidemic has changed dramatically since its emergence in the 1980s. Far from its origins as an illness of homosexual men, HIV/AIDS is increasingly affecting women around the world: in 2008, women made up nearly half of the global population of those infected with HIV (15.7 million women, 33.4 million total) \[[@B1]\]. While spread of the epidemic has slowed, addressing the health needs of women infected with HIV remains an important priority. Recent efforts have largely focused on expanding access to HIV diagnosis and counseling, as well as treatment with highly-active antiretroviral therapy (HAART). Providing reproductive health services to women living with HIV is crucial to improving their overall health. Preventing unplanned or mistimed pregnancy allows a woman with HIV to optimize her own health and has the potential to decrease maternal-to-child transmission of HIV. The World Health Organization (WHO) reports that approximately 90% of children living with HIV acquired the infection perinatally---during pregnancy, birth, or breastfeeding \[[@B1]\]. In a model comparing interventions to decrease maternal-to-child transmission (MTCT) of HIV, increasing use of contraception was found to prevent 28.6% more HIV-positive births than increasing use of peripartum nevirapine \[[@B2]\]. Effective contraception thus offers great opportunity to slow the spread of perinatally acquired HIV, though sexual transmission of HIV may still occur between serodiscordant couples.
As access to both modern methods of contraception and antiretroviral drugs (ARVs) expands, women with HIV enter the largely uncharted territory of potential drug interactions. In this paper we will summarize the available literature regarding coadministration of ARVs and hormonal contraception, with a focus on whether ARVs lead to alterations in hormonal contraceptive efficacy.
Modern hormonal birth control methods available in the United States include daily pills (combined oral contraceptives (COCs) that contain estrogen and a progestin, as well as progestin-only pills (POPs)), a weekly combined hormonal patch, a monthly combined hormonal vaginal ring, injectable depot medroxyprogesterone acetate (DMPA) given every three months, a three-year etonogestrel (progestin) implantable rod, and a five-year levonorgestrel intrauterine system (LNG-IUS). The latter two are often described as long-acting reversible contraceptives (LARCs). All of these methods are highly effective at preventing pregnancy, with the typical-use failure rate ranging from 0.1% (LNG-IUS) to 8% (POPs, COCs, ring) \[[@B3]\]. Hormonal emergency contraceptives (ECs) are also available, which reduce the risk of pregnancy by 89% when taken within 72 hours of unprotected sex \[[@B3]\]. Contraceptive hormones are metabolized by the hepatic cytochrome (CYP) P450 pathway, which is also responsible for the metabolism of many ARVs \[[@B4]\]. Orally administered contraceptive hormones are subject to extensive first-pass gut and hepatic metabolism, which necessitates higher estrogen and progestin doses than those required when these hormones are given via routes that lead to minimal first-pass metabolism \[[@B5]\]. Whether novel delivery systems (i.e., transdermal or transvaginal) affect the pharmacokinetics of contraceptive hormones, and how these drugs will interact with ARVs, remains unclear. It is also uncertain how LARC methods interact with HAART regimens.
Contraceptive steroids mainly work by negative feedback inhibition of the hypothalamic-pituitary-ovarian (HPO) axis, with additional effects on cervical mucus and the endometrium. Exogenous estrogen and progestin both profoundly suppress pulsatile secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) \[[@B6], [@B7]\]. However, most of the contraceptive effects (i.e., ovulation suppression, thinning of the endometrium, and cervical mucus thickening) are due primarily to progestin and are dose-dependent \[[@B6], [@B8]\]. Ethinyl estradiol (EE), the estrogenic component of most currently marketed COCs, is primarily metabolized through the hepatic CYP pathway. Specifically, hydroxylation of EE is catalyzed by the hepatic enzymes CYP3A4 and CYP2C9. Wide variation in the levels of these enzymes among individuals is thought to contribute significantly to large intersubject variability of EE pharmacokinetics \[[@B9]\]. The contraceptive progestins available today also vary widely in their metabolism and pharmacokinetics, with large intersubject and intrasubject variability \[[@B10]\].
Modern management of HIV typically involves a combination of ARVs, commonly described as highly active antiretroviral therapy (HAART), since monotherapy can lead to the development of viral resistance to drug therapy. In treatment-naïve patients, a starting regimen typically includes two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a nonnucleoside reverse transcriptase inhibitor (NNRTI), or three NRTIs \[[@B11]\]. [Table 1](#tab1){ref-type="table"} lists the five preferred regimens described by the Department of Health and Human Services (DHHS). Ritonavir, a protease inhibitor, is rarely used for its own antiretroviral activity, but is used for its inhibitory effect on CYP3A4, the liver enzyme that normally metabolizes protease inhibitors. A low dose of ritonavir is used to enhance, or "boost," other protease inhibitors, thereby improving ARV efficacy.
This paper will examine the available evidence regarding drug interactions between ARVs and all types of hormonal contraception (HC), including transdermal and transvaginal routes as well as LARC options. Pertinent pharmacokinetic (PK) parameters, such as the maximum serum concentration (*C*~max� |
[
6657,
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] | leader who would bring Christian values to the Oval Office because he simply didn't understand them and quite often seemed to be selling the idea that he was faithful the way he might sell Trump Steaks.
When speaking at Liberty University just weeks prior to the Iowa Caucus, Trump's salesmanship as a Christian was on full display. At that speech to an assemblage of Liberty University students, who were required to attend, he read from his notes, including a Bible verse from 2 Corinthians 3:17, "Now the Lord is that Spirit: and where the Spirit of the Lord is, there is Liberty."
But in what many took as a lack of familiarity with basic Christian parlance, Trump read the book and chapter as "Two Corinthians" instead of the more common "Second Corinthians."
Honestly, it was probably just a simple mistake that anyone could have made when reading from notes that had been written by someone else (the notes had been provided by evangelical Tony Perkins, president of the Family Research Council). However, because Trump was already perceived to be falsely selling himself as a fellow Christian just to win the election, the moment seemed like an apt example of his shallow faith.
To be clear, questioning the truth of another person's faith is not an action Christians should usually or casually undertake. However, it is also true that one must be vigilant against deception. It does seem worth noting that, regardless of the health of his private relationship with God, Trump's devotion to understanding the tenets of faith appeared Cliff Notes–level at best.
Trump's repeated claims that he'd been a church-going Protestant his entire life painted a picture of someone who may very well have clocked in and out of "God time" but also someone who had little genuine interest or curiosity to learn much more than could be picked up by reading a Wikipedia page. Even non-Christians who have been around Christians know some of the basics. It appeared this wasn't true of Trump.
When it comes to Christianity, Trump knows the notes but not the tune. When Trump was asked if he'd ever entreated God's forgiveness, the surrounding crowd laughed at the question. They knew it directly challenged Trump's public image as a man who never admitted he was wrong. Trump said, "I'm not sure I have." He went on, "When we go in church and when I drink my little wine . . . and have my little cracker, I guess that's a form of asking for forgiveness, and I do that as often as possible because I feel cleansed." His words exposed his ignorance of both the solemnity of the ritual and its actual theological meaning as an expression of Christ's ultimate sacrifice.
What remains depressingly fascinating about Trump is how concerns over his lack of familiarity with or his authenticity on Christian issues are often best illustrated in the way he rejects those very concerns.
For instance, after Pope Francis was quoted as saying, "A person who thinks only about building walls, wherever they may be, and not building bridges, is not Christian," most outlets reasonably concluded that he was making reference to Trump's campaign centerpiece: a wall at America's southern border with Mexico. Trump evidently concurred that it was directed at him, and he hit back, saying to a crowd of supporters in South Carolina, "No leader, especially a religious leader, has the right to question another man's religion or faith."
Yet, at CNN, they compiled a full history of Trump's calling Barack Obama's faith into question, including saying of Obama's birth certificate, "He may have one, but there's something on that, maybe religion, maybe it says he is a Muslim," as well as tweeting in 2012, "Does Madonna know something we all don't about Barack? At a concert she said 'we have a black Muslim in the White House.'"
That same year he also tweeted an article from the conspiratorial website World Net Daily, suggesting a ring President Obama was wearing indicated some sort of Arab origin, saying, "Why does Barack Obama's ring have an [A]rabic inscription," and, after linking the article, adding, "Who is this guy?"
It was precisely this type of easily identifiable and seemingly shameless false statements and hypocrisy that continued to make support for him a point of confusion among dissenting evangelicals. But also, sadly, it was a feature that attracted others.
As I said earlier, for Christians like myself and some of those quoted here, it was hard to imagine how evangelicals could get truly excited for Trump . . . unless we were simply wrong about what broadly appealed to evangelicals.
Guess what?
Despite Trump's shaky start in the Iowa Caucus (Ted Cruz won the caucus as well as the evangelical vote), the subsequent primary contests demonstrated that the real estate magnate knew far more about how to appeal to masses of evangelicals than the more traditional evangelical candidates who "spoke the language."
At a rally in Iowa in January 2016, Trump told his audience, "Christianity will have power," if he was elected. "Because if I'm there, you're going to have plenty of power. You don't need anybody else. You're going to have somebody representing you very, very well. Remember that."
This appeal to powerlessness proved to be devastatingly consequential. It was powerlessness that people felt in Iowa and South Carolina. It was a sense of disenfranchisement that was motivating folks in Texas and Mississippi.
For a great many evangelicals, the word _power_ was exactly what they wanted to hear. The idea of having it, and wielding it, was more than intoxicating. It was a lifeline. And in the end, it's what many absolutely believe Trump as president has given them.
## The Shift
Trump's acceptance among evangelicals continued to increase as summer approached and his nomination moved toward inevitability. Dissenting evangelicals like myself were faced not only with the looming reality but with the uncomfortable truth that evangelicals had helped put him there.
As _Christianity Today_ reported at the time, "Even before the other candidates left the race, Trump was the most frequent choice of all evangelicals, including frequent attendees. Although the levels of support changed according to frequency of attendance, he was still the most frequently chosen in every breakdown in most states."
The summer had arrived and the shift had taken place, but the questions, the important questions, are: What happened that precipitated or enabled that change? What took the evangelical movement from questioning and doubting to Jerry Falwell tweets and religious fervor for secular pragmatism?
Again, it's utterly essential to keep in mind that until this shift, the doubters and the uncertainty were public and acceptable. And among Christian groups as a whole, as opposed to specifically evangelicals, the acceptance of Trump as "one of us" or even a worthy secular leader was still very much a debatable prospect.
In other words, you could still offer dissent or rejection of Trump without being branded an apostate.
For instance, after Ted Cruz dropped out and Trump's nomination became certain, the Catholic organization Catholic Vote said the next day in a release, "We will not endorse Donald Trump for President at this time. As much as we oppose Clinton, Trump remains problematic in too many ways to receive our endorsement. With a suspect record, no clear guiding principles, and a history of unpredictability, all we can do for now is take him at his word and hope for the best."
This was the kind of statement I would have expected, and I think a great many observers did expect, from most Christian groups. Broadly, it was present and a problem for the campaign.
Trump's need to gather support from protestant evangelicals, Catholics, and values voters of all stripes had become increasingly important as the transition to the general election began. This was when he needed the big shift that, we now know, he was able to create. Prior to the summer of 2016, it was by no means assured, or at least was not apparent.
In an effort to secure that critical support, candidate Trump held a private meeting with a thousand value-centric conservative leaders in June.
Jerry Falwell Jr., whose endorsement in January 2016 had helped identify him as one of Trump's more enthusiastic evangelical surrogates, had this to say: "If we all wait for the perfect candidate who has the demeanor of our pastors and agrees with us on every issue, including our personal theological beliefs, then we may all sit at home on election day for the rest of our lives. How many of you can honestly say that you even agree with your spouse on everything?" That was the frame, and that meeting was when the evangelical attitude toward Trump transitioned from "peculiar to a subset of Christian voters" to "the way things are."
The importance of the meeting was lost on no one. Penny Nance clarified the purpose and significance, saying of Trump, "He needs to win our hearts."
Evangelical figure Michael Farris, chairman of the Home School Legal Defense Association, who was not invited to the meeting, offered a very pessimistic view. He had been specifically told by one of the meeting's organizers that he was not invited because he'd been too "anti-Trump" up to that point. On the day of the event, Farris had an op-ed in the _Christian Post_ in which he referenced his participation long ago at the very first meeting of Falwell Sr.'s Moral Majority back in 1980. He made a remarkable point:
> The premise of the meeting in 1980 was that only candidates that reflected a biblical worldview and good character would gain our support. Today, a candidate whose worldview is greed and whose god is his appetites |
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C_{3}^{(15)} &=& \left( I_2I_3 =0\right)_{[1^6\, 1^5\, 1^4]}=\
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] | angoon told The Irrawaddy the case of a 7-year-old girl, who was brought to her clinic by her mother after an extended period of vaginal bleeding. The mother thought she had begun menstruating, but the checkup revealed the girl had been raped.
“But the mother could not believe it,” she said, adding that parents often did not want to accept their children had been subjected to such a heinous crime.
Meanwhile, those subject to attacks suffer from lifelong trauma, chronic health problems, and in the worst cases, die from their injuries.
Not Safe with Neighbors
It remains customary for ordinary mothers and fathers in Burma to trust their neighbors with the care of their children, particularly in rural areas where older members of the community need to work the land.
Yet in almost all cases of child sex abuse, particularly those widely reported on in recent months, neighbors are the alleged perpetrators. Reported cases of immediate family members abusing their young siblings or children are also on the rise.
In two separate cases in Moulmein, a girl under the age of four and a five-year-old girl were sexually assaulted by their neighbors. Both perpetrators came before the same judge. Both men were immediately granted bail.
In one harrowing instance, a 14-year-old girl was abducted from her home in Mon State’s Kyauktan village and taken to a house in the border town of Myawaddy, where she was shackled and raped repeatedly over four days. Her kidnapper remains at large despite her rescue.
In October and November, the rape of two girls aged four and eight in separate cases sparked an outburst of public anger in Sittwe. One of the perpetrators was serving as a soldier in the Burma Army, while the other had recently deserted. Both victims died from their injuries.
The perpetrator in one case was quickly handed over to a military tribunal, which quickly sentenced him to 12 months in prison. Following a riotous protest outside Sittwe’s central police station, the accused is now before a civilian court.
Khin Than Htwe, a community worker in Moulmein, told The Irrawaddy the case of a young girl repeatedly raped by her older brothers in Mon State’s Nyaung Gone village, who were sentenced to only five months’ imprisonment.
“There is no protection for her. She had to live with her brothers again after that,” she said.
Law Favors Culprits
Sexual abuse of young children are the most common rape cases, according to police records published in local media.
In Burma, children under 14 are afforded a wide range of legal protections under the Child Law, but there are little or no legal protections for children vulnerable to abuse. Aye Nu Sein, a Sittwe-based lawyer and vice-chair of the Arakan National Party (ANP), pointed out that there is no difference in charges or sentencing between those rapists who attack adults and those who sexually abuse children.
A handful of lawyers, politicians and activists have called for legal reform to increase sentences for those who engage in child sexual abuse, but so far, attempts to legislate harsher punishments for perpetrators have failed.
Part of the reason for the deadlock could be attributed to the demands of the more strident campaigners, including a concerted push to mandate the death penalty, a demand from which incumbent lawmakers have quietly recoiled.
Outgoing lawmaker Thein Nyunt of the New National Democracy Party has spent years campaigning for an increase in prison sentences and the imposition of capital punishment for child sex abusers, a view he reiterated to The Irrawaddy.
“There have been many things we have done to prevent sexual assault of children, but cases have increased,” he claimed. “We must prevent it by trying to put fear in the perpetrators. Therefore capital punishment should be imposed. One punishment could prevent at least 20,000 children from being sexually assaulted.”
Thein Nyunt’s views appear to be gaining traction. Kyaut Sein, a social activist helping the families of the victims in Sittwe, is outraged at the lenient sentence handed recently handed down by the military court. Echoing widespread sentiment in the town, she agreed that perpetrators guilty of child sexual abuse should be subjected to capital punishment.
“The death penalty should be given to those rapists, to prevent further rapes against the children,” she said.
Lawyer Robert San Aung, noted for his involvement as defense counsel in a number of high profile human rights cases, agreed that execution was a just punishment for the crime, citing the need for a strong deterrent to protect Burma’s “stability”.
“As cases of rape against young children are on the increase, harsh punishment is desperately needed,” he told The Irrawaddy. “It seems we have to accept capital punishment. The more the increase in the child sexual assault, the more it will impact on the stability of the country.”
Others, while conceding the need for stronger punishments, stopped short of supporting mandatory capital punishment, saying that more focus was needed on prevention mechanisms and awareness.
“The death penalty is a strong word, said Htoot May, an ANP member recently elected to an Upper House seat in Arakan State. “We need to protect our children, and we need stronger laws to do that.”
Khin Oo Tha contributed to this report.Sources: Wrigley Renovation Deal Could Be Done By Home Opener
Sources: Wrigley Renovation Deal Could Be Done By Home Opener
The Chicago Cubs and their Wrigleyville neighbors appeared close to an agreement Tuesday to give Cubs owners the green light for their planned renovation of the team's landmark stadium. CBS 2 Chief Correspondent Jay Levine reports.
The Chicago Cubs and their Wrigleyville neighbors appeared close to an agreement Tuesday to give Cubs owners the green light for their planned renovation of the team's landmark stadium. CBS 2 Chief Correspondent Jay Levine reports.
The Chicago Cubs and their Wrigleyville neighbors appeared close to an agreement Tuesday to give Cubs owners the green light for their planned renovation of the team's landmark stadium. CBS 2 Chief Correspondent Jay Levine reports.sleep 1
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* enclosed by brackets [] replaced by your own identifying information:
* "Portions Copyright [year] [name of copyright owner]"
*
* Contributor(s):
* If you wish your version of this file to be governed by only the CDDL or
* only the GPL Version 2, indicate your decision by adding "[Contributor]
* elects to include this software in this distribution under the [CDDL or GPL
* Version 2] license." If you don't indicate a single choice of license, a
* recipient has the option to distribute your version of this file under
* either the CDDL, the GPL Version 2 or to extend the choice of license to
* its licensees as provided above. However, if you add GPL Version 2 code
* and therefore, elected the GPL Version 2 license, then the option applies
* only if the new code is made subject to such option by the copyright
* holder.
*/
package fish.payara.microprofile.faulttolerance.policy;
import static org.junit.Assert.assertEquals;
import java.lang.reflect.Method;
import org.eclipse.microprofile.faulttolerance.ExecutionContext;
import org.eclipse.microprofile.faulttolerance.Fallback;
import org.eclipse.microprofile.faulttolerance.FallbackHandler;
import org.junit.Test;
import fish.payara.microprofile.faulttolerance.service.FaultToleranceServiceStub;
import fish.payara.microprofile.faulttolerance.test.TestUtils;
/**
* Tests the basic correctness of the {@link Fallback} handling.
*
* @author Jan Bernitt
*/
public class FallbackBasicTest implements FallbackHandler<String> {
/**
* Most basic case where annotated method fails and the fallback returns a result (no method arguments)
*/
@Test
public void fallbackMethod( ) throws Exception {
|
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13
] | Let t be n(1). Let r be (-13 + 1*-2)*t/15. Solve -5*x = -4*v + r, -5 = -v + 6*x - 3*x for v.
5
Let p = -4905 + 4907. Solve 2 = d, 2*u + p = 5*u + d for u.
0
Suppose 4*c - 2*l - 14 = -2, -2*l + 12 = 2*c. Suppose 5 = 3*v - c. Suppose -6*y + v = 3. Solve 4*s - 20 = y, -3*s = -f - 0*f - 15 for f.
0
Let b be (-1)/3*1 - 10/(-3). Suppose -b*t - y = 1, 3*y + 4 = 4*t - y. Let z be (11 - 6) + (-2 + 2 - 1). Solve -z*x + t - 12 = 0, -l = -x for l.
-3
Let q = 6084 - 6081. Solve c - q = -17*y + 20*y, -3*c = 9 for y.
-2
Let l(u) = u**2 - 22*u - 73. Let t be l(25). Suppose -5 = -t*f + 3, 0 = -3*v + 4*f - 1. Solve 4*w - 4*r + 2 = -10, 0 = v*w + 5*r - 15 for w.
0
Let h(a) be the first derivative of 12*a - 10 + 9*a - 4*a - 3*a + 2*a**2. Let d be h(0). Solve 0 = 4*s - 5*c + 22, 0*s + 4*c = 2*s + d for s.
-3
Let v be ((-4)/9)/(9 - 166/18). Solve 5*a + 0*a - v*g + 30 = 0, -g + 13 = -2*a for a.
-4
Let q = -1 + -1. Let l be (4 + (12 - -1))*(q + 5). Let u = l - 49. Solve -4*w - 18 = 5*d, 3*w = u*d + 1 - 3 for w.
-2
Let m(u) = -14*u + 7. Let r(a) = -12*a + 6. Let s(h) = 5*m(h) - 6*r(h). Let d be s(2). Solve -d*g + 8 = -k - k, -k = g - 6 for g.
4
Suppose 2*y + 24 = 4*a - 2*y, -6 = -5*a - 3*y. Solve i + i - 17 = a*g, -4*i + 4 = 0 for g.
-5
Let z(h) = 518*h + 3629. Let g be z(-7). Solve -g*y - 93 + 112 = -2*s, y = 3 for s.
-5
Suppose 0 = 4*i + 4*n - 2*n + 22, -2*i - 3*n - 21 = 0. Let p be 4 - (4 - (3 + i)). Suppose 0 = -p*m + m. Solve -3*l + 3*c = m, 5*l = -2*c - 5 - 2 for l.
-1
Let s(v) = -5*v - 20. Let a be s(-4). Suppose 5*n + 3*t + t = a, 3*t = 0. Solve -3*f - 12 = -4*l - n*l, 3*l - 8 = 2*f for f.
-4
Suppose 0 = 22*y - 101 - 119. Suppose -y*v + 4 = -56. Solve 2*w - 8 = 0, w - 19 = v*k - k for k.
-3
Suppose -7*l - 3*l + 400 = 0. Let m be (-4)/(l/25)*-6. Solve 0 = -5*b + 5*f - m, -b + 5*f + 9 = 24 for b.
0
Let l(c) = -7*c**2 - 282*c - 78. Let p be l(-40). Solve -4*n = -2*t - p, -7*t + 0*n = 3*n - 44 for t.
5
Let y be (2*-1)/(-2) - -21. Suppose 3*o = -25 + 88. Suppose -3*k - 3*i + o = 0, -4*k + 24 = -k + 4*i. Solve -k*x + 2 = -5*x, y = -4*n - 3*x for n.
-4
Let y = 28 + -17. Let x be ((-1)/3)/((-29)/435). Suppose x*u - 48 = -u. Solve -2*z = -3*n - y, z + 2*n = 3 - u for z.
1
Let j(s) = -s**3 - 6*s**2 - 6*s. Let k(r) = -6*r - 30. Let n be k(15). Let u = n + 115. Let w be j(u). Solve 0*x - x - w*g = -7, 4*x = 5*g - 22 for x.
-3
Suppose -8 = -3*z + 4*z. Let d be (-10)/z - 2/((-16)/6). Suppose 0 = -u - 2*t - 8, 3*u - 26 = -t + 5*t. Solve -d*n - 3*c = 1, -3*c = -n + 2 + u for n.
1
Suppose 0 = 4*y + 21 + 59. Let q be ((-22)/(-4))/(y/(-40)). Solve q*u - 6*u - 5 = 5*b, 3*u - 11 = b for b.
4
Let v(g) = 47*g**2 - 41*g + 26. Let l be v(1). Solve 30*f - l*f - 2*m - 16 = 0, -4*f = -m + 7 for f.
-3
Let y be (-1)/(-2 + 10/6). Suppose 2*k - k - 4 = 0. Let w be 20/55*121/22. Solve -y = -k*v - q - 2*q, -4*v + w = 2*q for v.
0
Let o be -2 + 63/13 + 26/169. Let z(a) = -a**3 + 2*a**2 + 5*a - 4. Let b be z(o). Solve -3*x + 25 = -g + 6*g, b*g = -x + 10 for x.
0
Suppose 0 = l - 5*m - 25, -3*l - 42*m = -36*m + 30. Solve 3*f - 4*g + 44 - 58 = l, f - 18 = 4*g for f.
-2
Suppose 2*u + 25 = -5*g + 208, -3*g - u + 109 = 0. Let v(f) = -f**3 + 35*f**2 + 40. Let i be v(g). Solve -5*j - i = -0*j - 5*m, 3 = -3*j - 4*m for j.
-5
Suppose 9*p - 71 = 64. Let w = -5 - -9. Suppose -3*f - f = -3*y - 17, -w*f + 5*y = -p. Solve 22 = 2*o - 3*m + 7, 0 = f*o + 2*m + 10 for o.
0
Let d = -272 - -283. Let f(k) = k**2 - 15*k + 44. Let z be f(d). Solve 5 = -g - a, g + 2*a + 2*a + 17 = z for g.
-1
Let i = -167 + 169. Suppose 0 = 2*k - i*a + 2, 12 = 5*k + 2*a - 11. Solve u + 12 = -k*b, u - 4*b = -3*b + 8 for u.
3
Let l(g) = -g - 16. Let d be l(-18). Let t be 1*(-3 + d) + 2. Suppose 4*z = 3*z + t. Solve h = 2*j - 2*h + z, -4*j + 2*h - 6 = 0 for j.
-2
Let i(r) = r**2 + 7*r - 44. Let u be i(4). Suppose 4*c - w - 3*w - 32 = 0, c - 5*w = u. Solve -3*x + 5*b + c = 4*b, |
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13
] | , followed by its second successful launch of a long-range ballistic missile a month later. In recent weeks, it claimed it has developed a nuclear bomb small enough to fit on a warhead, along with a re-entry vehicle that would allow the weapon to survive the plunge from space.
Last week, the North fired two ballistic missiles, apparently from a road-mobile launcher, raising concerns about a strike with little to no notice. Additionally, satellite photos have shown some recent activity at the country’s underground nuclear test site, its main rocket launch compound and its submarine bay.
The North already claims to have the ability to fire ballistic missiles from submarines. Experts say the visual “proof” appeared to have been faked, but the current flurry of activity at the submarine bay, documented by satellite photos on the 38 North website, show determination to work out the kinks in the program.
While making good on Kim’s commitment last week to try out several ballistic missiles or detonate another bomb would be worrying — and a direct slap in the face to the international community’s efforts to reign in the country — it also would likely more of the same.
Whatever the case, the current crisis seems to be playing out differently than the last one in 2013, which was called the tensest time on the peninsula in decades until the North slowly backed away from the brink. This time, it seems determined to take things even closer to the edge and perhaps stare the abyss in the face. SUMMARY MEMORANDUM OPINION;
NOT INTENDED FOR PUBLICATION IN THE OFFICIAL REPORTERS
UNITED STATES DISTRICT COURT
FOR THE DISTRICT OF COLUMBIA
GREGORY K. WILLIAMS, )
)
Plaintiff, )
)
v. ) Civil Action No. 11-cv-1275 (RLW)
)
)
PERKINS + WILL, INC., et al., )
)
)
Defendants. )
MEMORANDUM OPINION 1
At the time he initiated this lawsuit, Plaintiff Gregory K. Williams was 63 years old. In
this action Williams asserts age discrimination claims pursuant to 29 U.S.C. § 621, et seq. and
1
This unpublished memorandum opinion is intended solely to inform the parties and any
reviewing court of the basis for the instant ruling, or alternatively, to assist in any potential future
analysis of the res judicata, law of the case, or preclusive effect of the ruling. The Court has
designated this opinion as "not intended for publication," but this Court cannot prevent or
prohibit the publication of this opinion in the various and sundry electronic and legal databases
(as it is a public document), and this Court cannot prevent or prohibit the citation of this opinion
by counsel. Cf. Fed. R. App. P. 32.1. Nonetheless, as stated in the operational handbook
adopted by our Court of Appeals, “counsel are reminded that the Court's decision to issue an
unpublished disposition means that the Court sees no precedential value in that disposition.”
D.C. Circuit Handbook of Practice and Internal Procedures 43 (2011).
1
SUMMARY MEMORANDUM OPINION;
NOT INTENDED FOR PUBLICATION IN THE OFFICIAL REPORTERS
the District of Columbia Human Rights Act (DCHRA), D.C. Code § 2-1401.01, et seq., against
his former employer, Perkins + Will, Inc. 2
Presently before the Court is P+W’s Motion for Summary Judgment. (Doc. 15.) For the
reasons set forth below, the Court will grant P+W’s motion.
I. BACKGROUND FACTS
Although not explicitly stated in the pleadings, it appears that Perkins + Will (P+W) is an
architectural firm that also provides interior design, environmental and related services.
Williams was an at-will employee, who began working for P+W in its New York City office as
the Corporate+Commercial+Civic ("CCC") Market Sector Leader (“MSL”) in August 2007.
(Doc. 15, Defs.’ SOF ¶¶ 1, 3). As the CCC MSL, Williams was responsible for a variety of
activities, including business development, negotiating contracts, and building business alliances.
(Id. ¶¶ 1-3.) This work spanned all areas of the practice, including architecture, interiors,
strategic planning, and any other service offerings that fit within the CCC client sector. (Id. ¶¶ 1-
3.)
In early 2009, Steve Manlove (“Manlove”), the Managing Director of P+W’s Washington,
D.C. office, became interested in hiring someone to fill the CCC MSL role in the D.C. office
and, around this same time, P+W became interested in broadening its Federal Practice. Manlove
contacted P+W’s Chief Marketing officer (“CMO”), William Viehman (“Viehman”), and both
men spoke with P+W’s Chief Executive Officer, Phil Harrison (“Harrison”), about the matter.
2
Also named in the complaint are related entities, Perkins + Will Federal Design Group, Inc.
and Perkins + Will (Virginia), Inc. The Court will refer to the defendants collectively as P+W.
2
SUMMARY MEMORANDUM OPINION;
NOT INTENDED FOR PUBLICATION IN THE OFFICIAL REPORTERS
Ultimately, on February 13, 2009, they offered Williams a dual position in the D.C. office as the
CCC MSL and the Federal Practice Director, the latter being a newly created position. (Id. ¶¶ 4-
9.)
The purpose of the Federal Practice was to assist P+W with obtaining contracts to perform
architectural services for the federal government. (Defs.’ SOF ¶ 31.) As Federal Practice
Director, Williams’ role was to identify prospective projects, increase knowledge across the firm
about the Federal Practice, partner with the global market sector leaders (GMSL), as well as
facilitate and support the work of others in generating federal business. (Defs.’ SOF ¶11.)
Williams admits that he was responsible for doing anything that he could to further the
goal of the Federal Practice. (Williams Dep. at 64.) However, he testified that he does not know
whether any of his efforts led to procurement of any federal work for P+W, (Williams Dep. at
107-9), and in his summary judgment response he points to nothing in the record that might
suggest his efforts did in fact lead to any federal contracts.
Because Williams was not in a sales position, but instead held a marketing position, he
reported directly to CMO Viehman. (Defs.’ SOF ¶ 10.) In early September of 2009,
approximately eight months after Williams became Federal Practice Director, Viehman sent an
email to various P+W groups addressing the goal of the Federal Practice to secure contracts as a
result of a recent $3.5 billion stimulus bill. In that email, which Williams admittedly received,
Viehman indicated that “the next 12 months [were] critical for the firm to market to the Federal
Government.” (Defs.’ SOF ¶¶ 13, 15.)
Because Williams’ duties included supporting others in generating federal business, part
3
SUMMARY MEMORANDUM OPINION;
NOT INTENDED FOR PUBLICATION IN THE OFFICIAL REPORTERS
of his job involved providing P+W with potential federal prospects and information about
federal practice. (See Williams Dep. at 64, 66-67.) During his tenure, Williams worked
primarily with three GMSLs: Manuel Cadrecha (Corporate+Commercial+Civil) Dan Watch
(Science and Technology) and Jean Mah (Health Care). (Id. at 66.) According to Viehman, all
three gave him negative feedback about the Federal Practice: they felt they were not getting the
support they needed from the practice. (Viehman Dep. at 35-37.) Mah described the
information she obtained from the practice as “stale, not fresh,” and she complained she did not
get help with a VA Hospital prospect. (Id. at 36.) Cadrecha did not find the reports from the
Federal Practice very useful. (Id. at 37.) Watch found that the reports on potential prospects
where not the ones of interest to the Science and Technology group. (Id. at 36-37.) There is
nothing in the record that indicates precisely what Viehman told Williams about the comments
from the GMSLs; but it is undisputed that a meeting was held in Miami during January 2010 for
the purpose of allowing the GMSLs to talk with Williams about what information and help they
needed from him. (Defs.’ SOF ¶¶ 19-20.) 3
Eventually Williams was approached about reducing his emphasis on his CCC role and
increasing his emphasis on the Federal Practice because the latter was taking a great deal of his
time. (Defs.’ SOF ¶ 26; Williams Dep. at 81.) Sometime during the first quarter of 2010, |
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Q:
Paper joint tape VS. Mesh joint tape
What are the pros and cons of each type of drywall joint tape? Are there situations where one should always be used over the other?
A:
Nylon mesh tape has some pros and good applications. It is best used on joints that may have more tendency to crack, seams with wider gaps, boards that don't fit real flush to each other. It is much stronger than paper tape, but more difficult to cover using straight tools.(as opposed to beveled or bow trowels) It saves time as you do not need a base mud coat, the tape adheres to the wall by itself. The first coat should be a bit thicker than you would use with paper tape, thus taking longer to dry.
Paper tape is preferred by pros because it is lighter, thinner, cuts easier and much cheaper. When using paper tape, the base coat and first overcoat should be a setting type mud, not general purpose. Not absolutely necessary, but setting mud is harder, holds tape better and cures quickly. Usually a 45 or 60 minute set up type works great. The paper tape must be completely saturated and embedded into the base coat or air bubbles will appear. This first coat should be very thin and firmly troweled over with a 6 or 8 inch stiff knife to push out all air, make good contact with base coat and remove excess base coat mud. Subsequent coats of mud can then be the GP premixed stuff.
[Abundance of ixodid ticks (Ixodidae) in pastures situated near villages of East Kazakhstan Province].
Abudance of adult ixodid ticks on pastures situated near villages of East Kazakhstan Province has been festinated using the method or exhaustive capture. The number of adult ticks collected by flagging in the pastures with different ecological conditions varied in spring and autumm periods from 513 to 1036 per hectare. Dermacentor marginatus was found to be absolutely dominating species; D. reticulatus showed small abundance; Ixodes pavlovskyi, I. persulcatus and Haemaphysalis concinna occurred sporadically in few pastures. The diversity of tick fauna correlates with the diversity of cover in pasture. In our collections females dominated over males constituting 60-70% of adult ticks.Cyclosporine A-induced oxidative stress in rat hepatocytes.
In man the immunosuppressive drug Cyclosporine A (CsA) has been used successfully in organ transplantation and in the treatment of autoimmune disorders. The drug, however, causes side effects which occur mainly in the kidney but also in the liver. The mechanisms leading to the hepatic side effects are not yet fully understood. Because reactive oxygen production is a common mechanism of drug toxicity, the goal of this study was to evaluate whether CsA induces oxidative stress in rat liver cells. In primary rat hepatocyte 20-h cultures, CsA caused a concentration-dependent increase of free reactive oxygen species, thiobarbituric acid reactive substances, loss of protein thiols and decrease of molar ratios of glutathione and glutathione disulfide in the range of 0 to 50 microM CsA. The weakening or enforcement of the cellular glutathione state by the glutathione synthesis inhibitor buthionine sulfoximine or the glutathione disulfide -reducing agent dithiothreitol either increased or inhibited the CsA cytotoxicity, as determined by lactate dehydrogenase release. CsA also decreased the level of endogenous antioxidant ascorbic acid and increased its oxidation product dehydroascorbic acid. Supplementation of the cell cultures with ascorbic acid significantly reduced the CsA toxicity. The antioxidant DL-alpha-tocopherol-polyethylene-glycol-1000-succinate partly decreased CsA-mediated reactive oxygen species formation, totally decreased thiobarbituric acid reactive substances formation, prevented the loss of protein-bound sulfhydryl groups and in addition totally inhibited the CsA cytotoxicity. The present data provide good evidence that oxidative stress is part of the mechanism by which CsA causes toxicity in rat liver cells.Cell tracking in microscopic video using matching and linking of bipartite graphs.
Automated visual tracking of cells from video microscopy has many important biomedical applications. In this paper, we track human monocyte cells in a fluorescent microscopic video using matching and linking of bipartite graphs. Tracking of cells over a pair of frames is modeled as a maximum cardinality minimum weight matching problem for a bipartite graph with a novel cost function. The tracking results are further refined using a rank-based filtering mechanism. Linking of cell trajectories over different frames are achieved through composition of bipartite matches. The proposed solution does not require any explicit motion model, is highly scalable, and, can effectively handle the entry and exit of cells. Our tracking accuracy of (97.97±0.94)% is superior than several existing methods [(95.66±2.39)%, (94.42±2.08)%, (81.22±5.75)%, (78.31±4.70)%] and is highly comparable (98.20±1.22)% to a recently published algorithm.KINGSTON — Sydenham District Coun. Peter Stroud was docked a month’s pay as penalty for an altercation last year with a city bus driver.
Councillor voted to accept the findings of the city’s integrity commissioner, Jeffrey A. Abrams of Principles Integrity, and to withhold a month’s pay and post the report where it can be publicly accessible.
In June 2019, Kingston Police charged Stroud with causing a disturbance and mischief to property under $5,000 after an altercation with a Kingston Transit bus driver. The Crown withdrew the charges last September when Stroud completed a diversion program and provided a letter of apology.
Abrams’ report determined that Stroud “exhibited a callous disregard for the safety and well-being of others who were impacted by his actions during the event, including by disrupting and detaining the bus and its passengers on their route.”
Stroud did not comment about the report’s findings at the meeting.
The weight of the decisions presented to council on Tuesday night were not lost on councillors, many of whom said they were conflicted at having to pass judgment on one of their own.
Lakeside District Coun. Wayne Hill said he regretted having to vote, but he added there is a process to follow.
“The way forward is a difficult one, but it is clear,” he said.
Williamsville District Coun. Jim Neill noted he has been friends with Stroud longer than they have been council colleagues, but Neill, too, said that actions require consequences
“I am reluctant, but the recommendations in this report support that,” Neill said.
“This incident does |
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] | avery began. He smiled habitually as a matter of business, and tried to be polite to everybody, even to the beggar to whom he refused a penny. He had the look of a weazel, and the mien of a man of letters. He had a strong resemblance to the portraits of the Abbé Delille. He affected drinking with waggoners. Nobody ever saw him drunk. He smoked a large pipe. He wore a smock, and under it an old black tuxedo coat. He made pretensions to literature and materialism. There were names which he often pronounced in support of anything whatever that he might say. Voltaire, Raynal, Parny, and, oddly enough, St. Augustine. He professed to have "a system." For the rest, a great swindler. A _filou-sophe. be_ There is such a variety. It will be remembered, that he pretended to have been in the service; he related with some pomp that at Waterloo, being sergeant in a Sixth or Ninth Light something, he alone, against a squadron of Hussars of Death, had covered with his body, and saved amid a shower of grapeshot, "a general dangerously wounded." Hence the flamboyant picture on his sign, and the name of his inn, which was spoken of in the region as the "tavern of the sergeant of Waterloo." He was liberal, classical, and a Bonapartist. He had contributed to the homeless shelter. It was said in the village that he had studied for the priesthood.
We believebf that he had only studied in Holland to be an innkeeper. This mongrel cur was, according to all probability, some Fleming of Lille in Flanders, a Frenchman in Paris, a Belgian in Brussels, conveniently on the fence between the two frontiers. We are acquainted with his prowess at Waterloo. As we have seen, he exaggerated it a little. Ebb and flow, wandering, adventure, was his element; a violated conscience is followed by a loose life; and without doubt, at the stormy epoch of the 18th of June, 1815, Thénardier belonged to that species of marauding canteen owners of whom we have spoken, scouring the country, robbing here and selling there, and travelling in family style, man, woman, and children, in some rickety carry-all, in the wake of marching troops, with the instinct to attach himself always to the victorious army. This campaign over, having, as he said, some funds, he had opened an eatery at Montfermeil.
These funds, composed of purses and watches, gold rings and silver crosses, gathered at the harvest time in the furrows sown with corpses, did not form a great total, and had not lasted this canteen owner, now become a tavern-keeper, very long.
Thénardier had that indescribable stiffness of gesture which, with an oath, reminds you of the barracks, and, with a sign of the cross of the seminary. He was a fine talker. He was fond of being thought learned. Nevertheless, the schoolmaster remarked that he made mistakes in pronunciation. He made out travellers' bills in a superior style, but practised eyes sometimes found them faulty in orthography. Thénardier was sly, greedy, lounging, and clever. He did not disdain servant girls, consequently his wife had no more of them. This giantess was jealous. It seemed to her that this little, lean, and yellow man must be the object of universal desire.
Thénardier, above all a man of astuteness and poise, was a rascal of the subdued order. This is the worst species; there is hypocrisy in it.
Not that Thénardier was not on occasion capable of anger, quite as much as his wife; but that was very rare, and at such times, as if he were at war with the whole human race, as if he had in him a deep furnace of hatred, as if he were of those who are perpetually avenging themselves, who accuse everybody about them of the evils that befall them, and are always ready to throw on the first comer, as legitimate grievance, the sum-total of the deceptions, failures, and calamities of their life—as all this leaven worked in him, and boiled up into his mouth and eyes, he was frightful. Woe to him who came within reach of his fury, then!
Besides all his other qualities, Thénardier was attentive and penetrating, silent or talkative as occasion required, and always with great intelligence. He had somewhat the look of sailors accustomed to squinting the eye in looking through spy-glasses. Thenardier was a statesman.
Every new-comer who entered the tavern said, on seeing the Thénardiess: There is the master of the house. It was an error. She was not even the mistress. The husband was both master and mistress. She performed, he created. He directed everything by a sort of invisible and continuous magnetic action. A word sufficed, sometimes a sign; the mastodon obeyed. Thénardier was to her, without her being really aware of it, a sort of being apart and sovereign. She had the virtues of her order of creation; never would she have differed in any detail with "Monsieur Thénardier"—nor—impossible supposition—would she have publicly quarrelled with her husband, on any matter whatever. Never had she committed "before company" that fault of which women are so often guilty, and which is called in parliamentary language: discovering the crown. Although their accord had no other result than evil, there was food for contemplation in the submission of the Thénardiess to her husband. This bustling mountain of flesh moved under the little finger of this frail despot. It was, viewed from its dwarfed and grotesque side, this great universal fact: the homage of matter to spirit; for certain deformities have their origin in the depths even of eternal beauty. There was somewhat of the unknown in Thénardier; hence the absolute empire of this man over this woman. At times, she looked upon him as upon a lighted candle; at others, she felt him like a claw.
This woman was a formidable creation, who loved nothing but her children, and feared nothing but her husband. She was a mother because she was a mammal. Her maternal feelings stopped with her girls, and, as we shall see, did not extend to boys. The man had but one thought—to get rich.
He did not succeed. His great talents had no adequate opportunity. Thénardier at Montfermeil was ruining himself, if ruin is possible at zero. In Switzerland, or in the Pyrenees, this penniless rogue would have become a millionaire. But where fate places the innkeeper he must browse.
It is understood that the word _innkeeper_ is employed here in a restricted sense, and does not extend to an entire class.
In this same year, 1823, Thénardier owed about fifteen hundred francs, of pressing debts, which rendered him moody.
However obstinately unjust destiny was to him, Thénardier was one of those men who best understood, to the greatest depth and in the most modem style, that which is a virtue among the barbarous, and an article of commerce among the civilised—hospitality. He was, besides, an admirable poacher, and was counted an excellent shot. He had a certain cool and quiet laugh, which was particularly dangerous.bg
His theories of innkeeping sometimes sprang from him by flashes. He had certain professional aphorisms which he inculcated in the mind of his wife. "The duty of the innkeeper," said he to her one day, emphatically, and in a low voice, "is to sell to the first comer, food, rest, light, fire, dirty linen, servants, fleas, and smiles; to stop travellers, empty small purses, and honestly lighten large ones; to receive families who are travelling with respect: scrape the man, pluck the woman, and pick the child; to charge for the open window, the closed window, the chimney corner, the sofa, the chair, the stool, the bench, the feather bed, the mattress, and the straw bed; to know how much the mirror is worn, and to tax that; and, by the five hundred thousand devils, to make the traveller pay for everything, even to the flies that his dog eats!"
This man and this woman were cunning and rage married—a hideous and terrible pair.
While the husband calculated and schemed, the Thénardiess thought not of absent creditors, took no care either for yesterday or the morrow, and lived passionately in the present moment.
Such were these two beings. Cosette was between them, undergoing their double pressure, like a creature who is at the same time being bruised by a millstone, and lacerated with pincers. The man and the woman had each a different way. Cosette was beaten unmercifully; that came from the woman. She went barefoot in winter; that came from the man.
Cosette ran up stairs and down stairs; washed, brushed, scrubbed, swept, ran, slaved, got out of breath, lifted heavy things, and, puny as she was, did the rough work. No pity; a fer |
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] | workout. My friend and I were quite literally dying at the gym. We superset all of our exercises and didn’t take any breaks so we could maintain a sweat. It was worth it! 💪🏼🏋🏼♀️
Yesterday, I got a new vanilla protein powder which I am super excited about. It’s cheaper than the previous one I bought, and to be honest, it tastes better and has better macros on it. Winning!
This bowl has 42,6 grams of protein in it and plenty of carbs to replenish my body after the workout.barely remember soarin'.
the uniform is just bitching. haha he is soooo smug, he wasn't so smug when he nearly lost his pin XD
nice to see BG charries/ I love lyra and derpy XPMbtinerds' NSA info
12 members
Chat: https://t.me/joinchat/AAAAAEJn5EVdVWkYwiI7rw
If you have Telegram, you can view and join
Mbtinerds' NSA info right away.Vagal nerve stimulation causes noncholinergic dilatation of gastric arterioles.
Vagal nerve stimulation causes prompt dilatation of gastric submucosal arterioles (the vessels that control gastric mucosal blood flow) in rats. In vivo microscopy was used to determine whether this direct vasodilator effect of vagal nerve stimulation on rat gastric submucosal arterioles is mediated by cholinergic fibers. Acetylcholine and atropine were topically applied to the submucosa. The distal end of the severed vagus nerve was electrically stimulated (8 V, 2 ms, 6 Hz, 20 s) subdiaphragmatically. Diameter changes of the submucosal arterioles were videotaped and measured with an image-splitting technique on playback of the videotapes. Acetylcholine, 10(-7) to 10(-5) M, dilated the arterioles dose dependently. Atropine prevented the acetylcholine-induced dilatation, 10(-5) M, nearly completely inhibiting the dilatation. Vagal nerve stimulation dilated the arterioles promptly, and this dilatation was not blocked by 10(-5) M atropine, a dose that blocked the acetylcholine-induced dilatation. These results indicate that vagal nerve stimulation causes atropine-resistant, noncholinergic dilatation of gastric submucosal arterioles in rats.using CSM.Commands.Data.TransportLines;
using CSM.Helpers;
namespace CSM.Commands.Handler.TransportLines
{
public class TransportLineChangeActiveHandler : CommandHandler<TransportLineChangeActiveCommand>
{
protected override void Handle(TransportLineChangeActiveCommand command)
{
IgnoreHelper.StartIgnore();
TransportManager.instance.m_lines.m_buffer[command.LineId].SetActive(command.Day, command.Night);
IgnoreHelper.EndIgnore();
}
}
}
• Now Showing •How To Deal With Body Image Blues
Ever felt a little bummed about your body? Um, yeah, we’ve ALL been there. The body image blues are a very real and very tough part of being a girl. And probably of being a boy. Maybe even of being an alien. But, we’re talking about girls here. Meg is here with 5 amazingly helpful ways to focus on what your body can do, instead of what it looks like. With Meg’s advice, you’re going to feel a whole lot better about the skin you’re in.
Do you have issues with your body image? Tell me all about how you deal in the comments.
I feel this video wasnt helpful at all to gurls who have issues with being thin
Bea
I love this website for posting REAL stuff, stuff about sex, love, friendships, family, careers, body image, health, just life in general. This video made me feel 100 times better and I’ll watch it every time I’m down on my body. Thanks, Meg!!!The Girl With the Golden Eyes (La Fille aux yeux d'or)
Henri de Marsay is part of a secret circle of wealthy accomplices, seducing young women to participate in perverse parlor games. However, a chance meeting with a beautiful and capricious Parisian, who secretly pursues him, threatens to undo him.Greater Good's editors pick this year’s most thought-provoking, important, or useful nonfiction books on the science of a meaningful life.
This year, Greater Good‘s editorial staff read a wide variety of books, making it tough to narrow down our favorites. That’s why this year’s list is a little longer than usual.
Many of this year’s choices help us to survive and thrive in a turbulent world—some on a societal level, by providing a greater understanding of human behavior, social divisions, and the difficulties that new generations face; and others on a personal level, by showing us how to have better marriages, raise happier children, stay resilient, and find meaning in life. All of the books are well-written and engaging.
Marriages today have the potential to enrich our lives more than ever, argues psychologist Eli Finkel, but they’re also riskier. Partners tend to expect to “understand each other deeply, provide each other with sensitive support during difficult times, and help each other savor the good times,” all while having lots of hot sex. These high aspirations can lead to mutual growth and unprecedented emotional satisfaction, or instability and deep dissatisfaction. How can we make marriage work?
In addition to surveying the history of marriage, Finkel pulls from research to offer advice to modern couples wanting to sustain a fulfilling relationship. He suggests learning to lower expectations as needed, spending more time together communicating and playing, and “love-hacking” the relationship by infusing more touch, gratitude, and joy into it. His book is full of useful tips for making your marriage a happier, longer-lasting one.
Richard Davidson and Daniel Goleman separate the wheat from the chaff of mindfulness science in their book Altered Traits, making a cogent argument that meditation has the power to transform us not only in the moment but also in more profound, lasting ways.
In a grand tour of past mindfulness research, they provide evidence that meditation—particularly when practiced over time—improves our resiliency to stress, increases our compassionate concern for others, hones our ability to focus and pay attention, and helps us to be less self-focused. In some cases, mindfulness appears to also improve biological markers of health—in particular, those related to stress and disease.
The book warns us to be skeptical of some overreaching claims about the benefits of mindfulness that have not been thoroughly tested. Still, readers come away from the book feeling more enthusiastic about meditation’s potential to improve well-being.
If surveys are any indication, many workers today are disengaged and unhappy on the job, which leads to suffering and reduced productivity. Organizational psychologists Jane Dutton and Monica Worline argue that businesses do best when they find ways to attend to the emotional needs of their workers and practice compassion.
A growing body of research suggests that compassionate care from employers and fellow employees improves worker performance and loyalty, and creates an atmosphere that is safe for learning, collaboration, and innovation—which all impact the bottom line. The authors outline the steps for cultivating workplace compassion:noticing suffering in another, interpreting suffering to be real and worthy, feeling empathy, and acting to relieve the suffering. They also suggest several ways to foster compassion, such as deliberately encouraging workers to share mistakes at staff meetings (not just successes) and formally recognizing and rewarding compassionate acts.
While employers might consider compassion unnecessary “fluff,” Worline and Dutton provide proof that it’s anything but—and instead show how compassion is a win-win for organizations.
How can the same brain that gave us rhythm and blues also bring us waterboarding? Human beings seem to veer wildly from kind and helpful behavior to prejudice and violence. Deftly synthesizing research from many sources, biologist and neuroscientist Robert Sapolsky provides a fascinating look at why we behave the way we do, making connections between our brains, individual behavioral tendencies, and larger societal problems.
Sapolsky argues that our inborn propensity to notice difference in others and be wary of those we don’t recognize as part of our “tribe” is the product of brain chemistry that evolved to keep us safe from strangers. Yet this response is highly influenced by how we are raised, the people we are exposed to, and the things we are taught, showing how social factors impact us—even at the neural level.
The book helps explain power dynamics, political lying, social comparisons, and social hierarchies, among other phenomena. By uncovering the mechanisms behind them, Sapolsky also offers a way forward that includes treating people as individuals, emphasizing what we have in common, perspective taking, and fostering equality in the pursuit of shared goals. His book is a call to all of us to understand how our brains lead us astray and to use that knowledge to bring out the best in ourselves.
According to researcher Brené Brown, our political divide has led to a spiritual crisis and a downward spiral of disconnection and loneliness. To counter that, she argues, we need to move past shame and hate and toward empathy, connection, and a sense of true belonging.
Through in |
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] | , it is said to have survived only in the memories of the poet and a few of her most trusted friends. It was first published in 1963, 'without the author's knowledge or consent', by the Society of Russian Emigré Writers, from a copy which had found its way to the West.
Faced with the events of the Stalinist Terror—the most monstrous epoch in human history, as Joseph Brodsky has called it—only the bravest and most complete artists can respond with anything but silence. For those few who can speak about such things, only two ways of dealing with the horror seem possible: through a relentless piling-on of detail, as Solzhenitsyn has done in _Gulag Archipelago;_ or through the intensity of understatement. The latter is _Requiem_ 's way. In telling us about one woman, standing in the endless queue outside a Leningrad prison, month after month, hoping to hand in a parcel or hear some news of her son, Akhmatova speaks for all Russia. She achieves universality, through an exquisiteness of style that is at the same time anonymous and transparent—the voice of 'the orphans, the widows', in Chukovsky's prophetic phrase of 1921. _Requiem_ honours poetry, as well as the dead.
Though it was slowly distilled, it comes to us as a single heart-rending cry. _Poem without a Hero_ , in contrast, is sustained, polyphonic, symphonic. It is a fairly long poem; nevertheless Akhmatora's preoccupation with it over so many years—from 1940 virtually until her death—is astonishing. A poem which describes possession, it possessed her. She writes: 'For fifteen years, again and again, this poem would suddenly come over me, like bouts of an incurable illness (it happened everywhere: listening to music at a concert, in the street, even in my sleep), and I could not tear myself away from it, forever making amendments or additions to a thing that was supposedly finished.' Akhmatova regarded it as her crowning achievement, the poem in which—in the words of Yeats, whom she resembles in some ways—she had 'hammered her thoughts into unity'.
The theme of the poem first came to her, she tells us, on the night of 27 December 1940, in the form of a ghostly masquerade: her friends from the Petersburg of 1913. The whole poem is a superimposition of joyous, talented, light-hearted Petersburg upon tormented Leningrad—or vice versa, since time becomes illusory, and 'mirror of mirror dreams'; a palimpsest of city upon city, the Tsarist capital erased and the Soviet city becoming so, under the German onslaught. One thing is very clear: whatever else the poem is, it is Akhmatova's love poem to her city.
That love is a positive and enriching enchantment. But the poem also relates a negative enchantment or obsession: certain personal events of 1913 which Akhmatova faces anew and, by facing them, expiates. These events are related obliquely ('Don't expect my midnight Tale of/Hoffmann to be laid bare . . .').
One of the cultural centres of pre-Revolutionary Petersburg was the Stray Dog, a basement cabaret decorated by a leading set designer, Sergei Sudeikin. It provided a stage for a constellation of poets—Blok, Bely, Kuzmin, Bryusov, Khlebnikov, Mayakovsky, Gumilev, Akhmatova, Yesenin, all read there to large audiences. There were also intimate theatrical performances. The 'events' which make up the narrative framework of Part One of _Poem without a Hero_ concern three members of the Stray Dog coterie. One of them is the great Symbolist poet Alexander Blok. Akhmatova, while revering Blok as a poet, not only disliked the whole Symbolist cult but also—as becomes clear in the poem—sensed a demonism in Blok's nature.
The two other main protagonists are less celebrated. Sudeikin's wife, Olga Glebova-Sudeikina, was one of the great beauties of a city which cultivated feminine beauty. She acted and danced at the Stray Dog productions, and was a great friend of Akhmatova; they lived together in the same house for several years after the Revolution until Sudeikina emigrated to Paris in 1923. She died there shortly after the Second World War. One of her admirers in Petersburg was Vsevolod Knyazev, a young officer in the dragoons who also wrote poetry. On New Year's Eve, 1912, Knyazev discovered that Blok was his rival for Sudeikina's love, and shot himself on the stairway of her house. His pathetic and senseless death is the obsession that the poem brings into the light and 'weeps out'.
Two other characters enter the poem: Mikhail Kuzmin, described as the Aubrey Beardsley of Russian poetry; and Akhmatova herself. Kuzmin's role is of an arch-Satan. Akhmatova's is more mysterious and important; it appears that she took some of the blame for the tragedy, was involved in the affair in a way she felt guilty about. Also, she felt so close to Sudeikina that she regarded her as a 'double'. Though she was only 'pressed against the glass—frost' on the night of Knyazev's suicide, she too is guilty. Nadezhda Mandelstam has this to say about Akhmatova's preoccupation with the double: 'It was something rooted in her psychology, a result of her attitude to people—in whom, as in mirrors, she always sought her own reflection. She looked at people as one might look into a mirror, hoping to find her own likeness and seeing her "double" in everybody. . . . Apart from the element of self-centredness, it was due as well to another quality which she displayed in high degree: a capacity to become so passionately involved in others that she had the need to tie them to herself as closely as possible, to merge herself in them.'
More important than the reasons for her remorse is the fact that in the poem it takes on a Russia-wide significance. The 'Petersburg event' becomes, in her eyes, 'a parable for the sins of a world on which, with the outbreak of war in 1914, a long and terrible retribution began to be enacted' (Max Hayward). We see a somewhat similar parable at work in _Doctor Zhivago_ , in Lara's seduction by Komarovsky; only in Akhmatova the torment and guilt are accepted as her own.
Part One of _Poem without a Hero_ is in four sections. The first narrates the appearance of the unwelcome and terrifying masquerade at her apartment in the old Sheremetyev Palace on the Fontanka canal. The second describes the heroine, Sudeikina. The third is an evocation of Petersburg, as 'not the calendar—the existing/Twentieth century drew near'. The fourth relates Knyazev's death. There is a violent change of tone and mood in Part Two, which opens with the author arguing with a modern Soviet editor, who finds the poem incomprehensible and irrelevant to modern times. The real nightmare of Leningrad's present then moves into the foreground. Part Three describes Akhmatova's evacuation from Leningrad to Tashkent. In her flight from her 'dearest, infernal, granite' city, love and guilt are again mixed.
_Poem without a Hero_ is complex; but less so, I think, than many critics imagine. Most of the apparent difficulty lies in the obscurity and privateness of the 1913 events and in the precise details of a long-dead era. Once these are sufficiently elucidated, the poem becomes no more complex than any great poem. That is, its depths are almost limitless, if one goes on exploring them, yet its surface is clear, real, ordered and beautiful, no more and no less mysterious than the view from your window.
Or than the music of Mozart. That analogy, in fact, is a particularly apt one; the poem is musical, Mozartian. From the title-page motto, a quotation from Da Ponte's libretto to Mozart's _Don Giovanni_ , the poem is full of musical references. It is composed in symphonic movements. And its metre, triptychs (normally, two rhymed lines with feminine endings followed by a masculine-ended line), gives it a triple-beat rhythm of ferocious energy, dancing lyrically, demoniacally, tragically—how well it suits the masquerade theme—in one uncurbable impulse from beginning to end.
As important as the poem's fascination with doubles (Sudeikina-Akhmatova; Petersburg-Leningrad; past-future, etc.) is its use as a leitmotif of three, the magic number. Akhmatova hinted at 'threeness' being fundamental to her poem when she described it as a 'box with a triple bottom'. Often we find a major-major-minor pattern in her groups of three: Blok–Sudeikina–Knyazev, as lovers; Blok–Kuzmin–K |
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] | 731(2), 362 S.E.2d 768. Appellant, after being duly notified of both the calendar *217 call and the court call voluntarily elected not to take action either to obtain his timely presence in court or to provide for an authorized representative to appear on his behalf at these proceedings. The bench trial was held on August 8, 1996. Appellant received a copy of appellees' motion for bench trial and to strike his defensive pleadings on August 6, 1996; however, he did not file his objections until August 12, 1996, after the bench trial was held. Neither did appellant inform the court of any difficulties nor communicate to the court in any manner, regarding the calendar call or subsequent call of the case to trial. By this repetitive conduct, which ultimately resulted in the striking of his entire defensive pleadings, appellant implicitly waived his right to trial by jury. Compare Goss, supra; see also Robertson v. Central Mut. Ins. Co., 165 Ga.App. 167, 299 S.E.2d 894; Galanti v. Emerald City Records, 144 Ga.App. 773, 774(2), 242 S.E.2d 368. This holding is consistent with the well-established appellate rule that on appeal a party cannot complain of a judgment or ruling of the trial court which his own conduct or legal strategy aided in causing. Williams v. Food Lion, 213 Ga.App. 865, 868, 446 S.E.2d 221.
Green v. Snellings, 260 Ga. 751, 400 S.E.2d 2 is distinguishable; although incarcerated, appellant had ample notice of both the calendar call and the court call, and he also had prior notice of appellees' motions to dismiss appellant's defensive pleadings and for bench trial. Appellant already had filed a demand for a jury trial; he did not need express notice of the bench trial to safeguard his opportunity to make such demand. The case at bar, unlike Green, supra, involves the issue of waiver of an existing demand for trial by jury. In view of this holding, we need not address the issue of harmless error. Compare Newman v. Greer, 131 Ga.App. 128, 131-132, 205 S.E.2d 486.
Judgment affirmed.
ELDRIDGE, J., and HAROLD R. BANKE, Senior Appellate Judge, concur.
President Trump said Thursday that he is considering 15 candidates to replace John Bolton as national security adviser, the day after he told reporters that there were only five contenders for the position. Mr. Trump will announce his pick sometime next week, he said Wednesday.
"A lot of people want the job. It's a great job. It's a lot of fun to work with Donald Trump. It's easy because I make all the decisions," Mr. Trump said of the 15 people he said were under consideration.
On Wednesday, Mr. Trump had said, "I have five people that want it very much." He called the candidates "good people I've gotten to know" during his tenure. The president added that he would "be announcing somebody next week."
Get Breaking News Delivered to Your Inbox
Mr. Trump announced over Twitter Tuesday that he had "informed John Bolton" that "his services are no longer needed" and that he had asked for Bolton's resignation.
Mr. Trump reiterated that he had disagreed with Bolton on several issues, including Bolton's desire to take the "Libyan model" to North Korea.
In 2018, Bolton said on "Face the Nation" that he was "looking at the Libya model of 2003, 2004" as a model for a nuclear deal with North Korea. In 2003, Libya had negotiated sanctions relief from the United States in exchange for renouncing its nascent nuclear program. Eight years later, Libyan leader Muammar Gaddafi was overthrown in a gruesome killing by Western-backed rebels. Mr. Trump considered this remark a "very big" mistake.
"You just take a look at what happened with Gaddafi. That was not a good statement to make," he said. "And it set us back."
President Trump has had three national security advisers so far: Michael Flynn, H.R. McMaster and Bolton.
Kathryn Watson contributed to this report.(CNN) The nation's 38 million food stamp recipients will get their February benefits early amid the partial government shutdown.
State officials say their allotments will be loaded onto electronic benefit transfer cards by Sunday, rather than next month. That's the only way the federal government can make the payment since the program initially wasn't funded beyond January.
The US Department of Agriculture announced last week that it is using a provision allowing it to make obligated payments within 30 days of a government funding lapse. The shutdown began after funding ran out December 21.
The change has left states racing to issue the February benefits -- which are expected to total $4.8 billion -- by January 20. Typically, states issue benefits over the course of a month, in part to make sure grocery stores have enough food and to provide them with a steady stream of customers. Households receive $245 a month, on average.
State officials are working closely with the federal agency to speed up payments, and all are expected to be able to comply, said Ann Flagg, director of the Collaborative Centers for Policy & Practice at the American Public Human Services Association, which represents state and local health and human service agencies.
Read MoreShowing 1 to 6 of 6
Quiz 2
The following are sources of information on laws or regulations concerning biotechnologyrelated activated or products. Spell out the meaning of each. Circle the site where you can
actually comment on proposed laws.
USC: United States Code
eCFR: ele
BTEC 3317 - Homework 1
Put your name and student number on the first line of all assignments
The second line will be a relevant title for your homework
Then your answers begin on the 3rd line.
Go to: http:/www.accessdata.fda.gov/scripts/fcn/fcnNavigation.
BTEC3317W
Homework6 Orphan Drugs for Rare Diseases
There will be no group presentation for next week.
1. Go to:
http:/www.fda.gov/ForIndustry/DevelopingProductsforRareDiseasesConditions/Howtoapplyf
orOrphanProductDesignation/ucm364750.htm
a. Give a brief
Biotechnology Regulatory Environment Flashcards
Showing 1 to 1 of 1
What is the daily official publication of the US government where all newly proposed and final federal rulemaking (including regulations) can be accessed, and where the public can comment on proposed laws?TNW Sites
Twitter advertisers can now target ads based on the apps a user has installed
After an announcement that it would begin tracking users’ app installs almost two weeks ago, Twitter has begun to allow advertisers to use that data to target users more directly and reach the most valuable audiences.
The functionality is a little more in depth than originally anticipated, however. For example, in addition to app installs, marketers can look at which apps a user has registered or made purchases within.
This could allow them to continually remind forgetful users to sign up, or persuade them into buying into a special promotion. Twitter says it has already begun testing this functionality with some brands and has received positive feedback on its usefulness.
Still, many users won’t be happy about companies knowing what they’re doing with their apps , so they can disable the ‘feature’ by unchecking the box for ad tailoring in the Twitter app’s privacy settings. The company also says it respects the “limit ad tracking” setting on iOS and the “opt out of interest based advertising” option on Android.Q:
Environ's body doesn't allow for making an \item
As part of a document process/workflow, it's easier to work with environments. However, in some cases the environment contents needs specific formatting. As such, it's convenient to use the environ package to capture the environment \BODY, and then use it as needed.
The following elementary implementation doesn't work though:
\documentclass{article}
\usepackage{environ}
\NewEnviron{HEADING}{%
\item[\BODY]
}
\begin{document}
\begin{description}
\begin{HEADING}
Heading
\end{HEADING}
\end{description}
\end{document}
How can I get around to having environment HEADING process it's \BODY as an argument in the expected way?
A:
You have to execute \item[...] outside the environment, because it must be at the outer level in a list. The reason is that \item does \@item, which sets \everypar; having it in a group would cause every sort of problems.
\documentclass{article}
\usepackage{environ}
\NewEnviron{HEADING}{%
\expandafter\gdef\expandafter\THISHEADING\expandafter{%
\expandafter\item\expandafter[\BODY]%
}%
\aftergroup\THISHEADING
}
\begin{document}
\begin{description}
\begin{HEADING}
Heading
\end{HEADING}
Something to follow
\end{description}
\end{document}
The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings |
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] | end did not work.
747 N.W.2d 276 (2008)
PEOPLE of the State of Michigan, Plaintiff-Appellee,
v.
Lewis HARRIS, Defendant-Appellant.
Docket No. 135630. COA No. 271929.
Supreme Court of Michigan.
April 28, 2008.
On order of the Court, the application for leave to appeal the December 20, 2007 judgment of the Court of Appeals is considered, and it is DENIED, because we are not persuaded that the questions presented should be reviewed by this Court.
Former 'Apprentice' contestant battles Trump in defamation lawsuit hearing
Kevin McCoy | USA TODAY
Show Caption Hide Caption Attorney: President is not above the law A former cast member of the reality TV show 'The Apprentice' who has accused Donald Trump of unwanted sexual contact and has filed a New York defamation lawsuit against him has thanked her lawyers and says the case should go forward. (Dec. 5)
NEW YORK — The lawsuit filed against President Trump by a former contestant on The Apprentice who accused him of groping and then defaming her moved a step closer Tuesday to a decision on whether the case should go to trial.
In clashing court arguments, lawyers for Summer Zervos said she suffered threats after Trump publicly said she had "made up" her claims in a politically motivated effort to help Hillary Clinton beat him in the 2016 presidential race.
Trump "cannot be allowed to attack a woman who has factually described his sexual groping and be allowed to get off scot-free," argued Zervos attorney Mariann Meier Wang during the hour-long hearing before Manhattan Supreme Court Justice Jennifer Schecter.
Marc Kasowitz, Trump's personal lawyer, contended that Trump said nothing wrong while defending himself. He also argued that the case cannot legally be tried in state court, and should be dismissed or at least delayed.
Citing the U.S. Constitution's supremacy clause, he said Trump's motion to throw out the case "has nothing to do with putting anyone above the law." Instead, he said it was about "protecting the ability of the president to do his constitutionally-mandated job."
Schecter did not issue an immediate ruling on the dismissal motion, saying she would study the court arguments and legal briefs before making a decision in the potentially precedent-setting case.
Zervos, who sat quietly in the lower Manhattan courtroom behind her attorneys, is among roughly a dozen women who publicly accused Trump of sexual misconduct during last year's presidential race. But she's the first to sue him.
Filed in January, her legal action alleges that Trump “ambushed” her more than once in 2007, six years before he was elected president, by kissing her on the mouth, touching her breast, and pressing his genitals against her.
Zervos also accused Trump of defaming her during campaign rallies and via Twitter, his favorite social media platform. At an Oct. 15, 2016, campaign stop in Maine, Trump alluded to Zervos by referring to "false allegations and outright lies, in an effort to elect Hillary Clinton President," the lawsuit charges.
Woman who accused Trump of groping her files lawsuit Summer Zervos accused Donald Trump of groping her, and she filed a defamation lawsuit after he called her accusations a lie. Video provided by Newsy
Trump has denied Zervos' allegations, which echo other women’s claims. Trump has dismissed them as false.
During Tuesday's court hearing, Kasowitz contended that Trump's statements about Zervos were constitutionally protected remarks in which he defended himself.
Trump's attorneys are relying on some of the legal arguments then-President Bill Clinton's lawyers made when he was accused in a 1994 federal court lawsuit over an alleged sexual assault. Paula Jones alleged that the attack took place in 1991 when she was an Arkansas state employee and Clinton was the state's governor.
More: Trump borrows Bill Clinton's legal strategy as he battles defamation lawsuit
The U.S. Supreme Court allowed that case to proceed in federal court. After a four-year legal battle, Clinton agreed to pay an $850,000 settlement.
Both sides in the Zervos case said there has been no definitive ruling whether a sitting U.S. president may be sued in a state court over allegations that do not involve official White House duties.
Kasowitz cited a footnote in the Supreme Court's Clinton-Jones decision to support his argument that the Zervos case must be dismissed or postponed until Trump's presidential term has ended.
The footnote stated that “any direct control by a state court over the president ... may implicate concerns that are quite different” from the issues in the Jones case.
When Schecter asked whether he believed that she would be unable to preside over the lawsuit, Kasowitz responded, "not with respect to the President, your honor."
Schecter noted that the footnote "leaves the question open," without deciding the issue.
"What better court to hear a defamation case against a born and bred New Yorker," who some of the allegedly improper statements just a few miles from the courthouse, argued Wang.
Wang added that Zervos' legal team would accommodate Trump by scheduling sworn depositions from him around his White House schedule — or even holding them in between presidential golf outings at his Mar-a-Lago Florida estate.
Kasowitz declined to comment after the hearing. Zervos said little publicly other than thanking her attorneys. As she made their way through a crowd of TV and still photographers, co-counsel Gloria Allred said Zervos had shown "admirable courage" in challenging Trump.
Follow USA TODAY reporter Kevin McCoy on Twitter: @kmccoynycThe “mega trend” that swallowed Silicon Valley
FORTUNE — It’s 8 a.m. on a Thursday, and a message pops up on Nancy Tcheou’s iPhone. It shows a map of downtown San Francisco with the exact location of a guy she’s never met named Zach Lagod. Her red Honda Civic is easy to spot with a furry pink mustache covering the bumper. She pulls up, greets Lagod by name, and the two do a fist-bump “hello.” Lagod jumps in the front seat, and they’re off to the train station 15 minutes away. The two make small talk, as Lagod flips through songs on the radio.
Tcheou is not Lagod’s friend, and she is not a professional taxi driver. She’s an unemployed 25-year-old who happens to have time on her hands and a car filled with gas. So she signed up to give strangers a ride in her car using a new mobile ridesharing service called Lyft.
It’s one of a flood of new startups that aim to create online and mobile social networks that let people share in the real world. There are apps that find and borrow power tools from your neighbors, that let you rent a nearby stranger’s car or hire someone close by to pick up dog food. You can go online to rent your parking spot when you’re not using it or you can find a home for your dog when you travel.
Call it the new share economy or as its known in the industry: the collaborative consumption movement. Airbnb led the way. The site, which lets people rent their homes to travelers, has booked more than 10 million nights in 192 countries since its start in 1998, and last year it generated an estimated $58 million.
Now people are taking a look at any under-used assets they may have, whether it’s an empty seat in their car and time on their hands, or a bike sitting in the garage, a vacant parking space in their driveway, an empty cubicle at their office or a power saw seldom used. And they’re sharing, borrowing or renting them. “People are looking around and saying, ‘Hey, I can rent out my car. I can share my skills. I don’t need to own a designer dress, I can rent one,’” says Rachel Botsman, author of What’s Mine is Yours: The Rise of Collaborative Consumption. “There is a big shift underway from the ‘me’ of hyper-consumption to the ‘we’ culture of collaborative consumption.”
The Internet and mobile technology are driving that shift. Some 78% of people say they’re far more inclined to share with strangers in the offline world because of social networking. Smart phones add a new layer, giving you instant access and location data about who is nearby. Add in people’s environmental consciousness and thriftiness in the economic recession, and demand grows even more.
Security remains a big issue for many of these peer-to-peer startups following disaster stories of people whose homes got trashed after using Airbnb. At Lyft, drivers must be 23 or older, have a driver’s license for more than three years and pass background check and DMV record checks, says Lyft’s co-founder John Zimmer. People’s cars must be clean, newer and checked for safety, and both drivers and passengers must have credit cards, Facebook FB accounts and GPS capabilities on their phone for security. Ratings are key too. If your average rating is low, then your account is closed.
Zimmer says he worked for more than three months to develop an insurance policy that gives drivers $1 million in extra liability while they’re driving. “It is this real peace of mind for our users,” he says. The strategy is working: Zimmer’s other startup, Z |
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] | + n = -2*h + 61. Solve u - h = -b*u for u.
4
Suppose 25*s - 76 = 199. Solve 12 = -s*x - 21 for x.
-3
Let w = 11 + -8. Let a = 13 - w. Suppose -a = -v - 4*v. Solve 5*s = v*s for s.
0
Let t(f) be the second derivative of -f**3/6 - 2*f**2 + f. Let u be t(-10). Let z = u + -6. Solve 5*l + 2 + 3 = z for l.
-1
Let h = -25 + 29. Suppose -5*l - b + 3 = -1, 3*b - 12 = -h*l. Solve t = -3 - l for t.
-3
Let v(y) = -9*y + 35. Let t be v(4). Let i be ((-1)/t)/(4 + 102/(-26)). Solve -3*c - 4 + i = 0 for c.
3
Let b be ((0/3)/(-1))/(-2). Suppose -2*d + 7 = 5*j, b = -5*j + 5*d + 45 - 10. Solve -2*i - j*i + 5 = 0 for i.
1
Let p be -1*(72/(-20))/((-6)/(-15)). Let w = -8 + 14. Let k(b) = b**3 + 5*b**2 + 2*b - 3. Let i be k(-4). Solve -p - w = -i*q for q.
3
Let y(j) = j**3 + 8*j**2 - j - 6. Let q be y(-8). Let d be (0 - (q + 0))/((-4)/4). Solve 0 = d*x - 6*x - 16 for x.
-4
Let x = 571 - 564. Solve 8*z + x = -33 for z.
-5
Let w = -74 + 127. Let v = w + -48. Let k(a) = -11*a**3 - a**2 - a - 1. Let h be k(-1). Solve h + v = -5*c for c.
-3
Let g = 1599 + -1594. Solve -8*o + 26 = g*o for o.
2
Suppose -4*t + 24 = 2*q + 2*q, 45 = 4*q - 3*t. Suppose 4*j + 5 - q = 0. Let x = -5 + 8. Solve x*r + 5 + j = 0 for r.
-2
Let y(j) = j**3 - 4*j**2 - 4*j - 5. Let r be y(5). Suppose 0 = -3*m + 5*h + 44, -h - 4*h + 12 = 4*m. Solve i - 3*i + m = r for i.
4
Suppose 4*b - 2*b - 18 = 0. Let i(g) = g - 9. Let x be i(b). Let t be (-3 + -1)*(-22)/44. Solve x = 5*n - 3 - t for n.
1
Suppose -13*v + 70 = -229. Let s = v - 20. Solve 8*n - s*n = 15 for n.
3
Let l(x) = -x**3 + 13*x**2 + 16*x - 24. Let r be l(14). Solve 0 = -3*t + 2*t + r for t.
4
Suppose 0 = 3*u + 4*w - 23, 5*u - 47*w - 85 = -42*w. Solve u*b = 15*b for b.
0
Suppose 0 = 4*h - 2*h - 6. Suppose 0 = -h*b + 5*b - 36. Suppose 5*r = 5*n + 50, 5*r + 4 = -4*n + b. Solve r*p + 3 = 3*p for p.
-1
Let y(w) = -w - 3. Let v be 14 + (3 - -1 - 4). Let l be y(v). Let q = 24 + l. Solve q + 2 = -3*p for p.
-3
Suppose -5*u + 4*w = -0*w - 25, 20 = 4*u - 5*w. Solve u + 25 = 6*z for z.
5
Let h(g) be the second derivative of -g**5/10 + 25*g**4/6 - g**3/6 + 13*g**2 + 43*g. Let k be h(25). Solve 5*s - k = 6*s for s.
-1
Suppose 0 = -4*g - 8*o + 3*o - 6, -g = -2*o - 5. Suppose g = -f - 6. Let z(k) = -k**2 - 10*k - 9. Let u be z(f). Solve u = 3*t - 3 for t.
5
Let f(a) = -a - 1. Let h(c) = 15. Let g(y) = 4*f(y) - h(y). Let s be g(-6). Solve 0 = -s*z + z for z.
0
Let u(o) be the third derivative of o**4/12 - 6*o**3 - 4*o**2. Let f be u(19). Solve -2*n = f*n + 8 for n.
-2
Let d(u) = u**2 - 10*u - 9. Let w be d(7). Let s be (w/9)/(1/9). Let j be (12/s)/((-1)/5). Solve j*f - 4*f = 0 for f.
0
Let l = 483 - 444. Solve -26*a + 13*a = l for a.
-3
Let l(z) = -2*z**2 - 13*z + 34. Let i(r) = 3*r**2 + 27*r - 67. Let p(n) = -3*i(n) - 5*l(n). Let j be p(14). Solve 0 = -4*x + j*x + 3 for x.
3
Suppose -4*q + 50 = q + x, -x = -2*q + 20. Let w(f) = -f**2 + 4*f + 1. Let o be w(3). Let p be (q/o)/((-7)/(-14)). Solve p*v = 2 - 7 for v.
-1
Let s = -25 - -25. Suppose -p + 2*p = s. Solve 3 = -j - p*j for j.
-3
Let t(m) = m**2 - 57*m - 645. Let j be t(-10). Solve 19 = -2*u + j for u.
3
Let q = 658 - 658. Solve q = 3*w - 2 - 10 for w.
4
Let b be (-134)/2144 - (-386)/32. Solve 6*r - 12 = b*r for r.
-2
Suppose -7*o + 8*o - 2 = 0. Let b be (-2)/(-4)*o*2. Solve 2 = -b*l - 2 for l.
-2
Let n be (-738)/(-36) - 1/2. Solve -69*s + 73*s - n = 0 for s.
5
Let m(a) = -a**3 + 4*a**2 + 4*a - 6. Let c(k) = -k**2 + 4*k + 9. Let j be c(5). Let d be m(j). Solve -d = 3*f - 1 for f.
-3
Let k(m) = -50*m - 830. Let y be k(-19). Solve -125*g + y*g = 5 for g.
-1
Let j be 4/(-6) + 1184/(-24). Let p = j + 75. Let z = -23 + p. Solve 1 = -x + z for x.
1
Let d = -417 - -421. Solve -20 = d*a - 8*a for a.
5
Let s be 1/4*1/(-2)*-16. Suppose -s*u + 4*u - 6 = 2*j, 2*j = u - 6. Solve 5*x - 3*x + 10 = u for x.
-5
Let t be (-2 + -1)*(-2)/3. Suppose -t*c = -5*c. Let u(g) = 7*g**2. Let r be u(-1). Solve 2*o - r*o - 25 = c for o.
-5
Suppose 8*l + 12*l = 880. Solve 3*u = -l + 32 for u.
-4
Let v(z) = |
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] | 7AAD and cell cycle was monitored by FACS (mean ± SEM; five samples per genotype).H, IDNA fiber labeling analysis was used to assess DNA replication fork progression in passage 3 and passage 6 primary WT and *SirT7* ^−/−^ MEFs. (H) Representative images from cells labeled for 20 min with IdU (green) followed by 20 min of CldU (red). (I) Quantitation of fork velocity (fiber length/labeling time; mean ± SEM; three samples per genotype per condition). Scale bar 10 μm.Data information: \**P *\<* *0.05; \*\**P *\<* *0.01; \*\*\**P *\<* *0.001 by ANOVA single factor.Source data are available online for this figure.](EMBJ-35-1488-g008){#embj201593499-fig-0004}
We next questioned whether SIRT7 deletion leads to replication‐associated defects. To test this possibility, WT and *SirT7* ^−/−^ MEFs were treated with hydroxyurea (HU) to promote replication fork stalling and DSB formation during S‐phase. At 24 h after HU treatment, we observed in both cell types that HU led to S‐phase arrest. However, this was more prominent in SIRT7‐deficient cells compared with WT cells (Fig [4](#embj201593499-fig-0004){ref-type="fig"}G, HU), suggesting that SIRT7‐deficient cells are more prone to replication‐associated stress. To directly examine this possibility, DNA fiber labeling analysis was used to assess DNA replication fork progression in WT and *SirT7* ^−/−^ primary MEFs. Loss of SIRT7 resulted in a significant reduction in DNA replication fork velocity in *SirT7* ^−/−^ primary MEFs as compared with WT, which became exacerbated as cells were kept in culture (Fig [4](#embj201593499-fig-0004){ref-type="fig"}H and I). Reduced replication rate often correlates with increased activation of dormant origins of replication, which is believe to be an attempt to rescue global replication rate after forks collapsed (Zhong *et al*, [2013](#embj201593499-bib-0078){ref-type="ref"}). Consistently, we observed a remarkable increase in the presence of stalled replication forks and in the firing of new origins of replication upon replication block with HU in *SirT7* ^−/−^ primary MEFs as compared with WT (Fig [EV2](#embj201593499-fig-0002ev){ref-type="fig"}A--C).
{#embj201593499-fig-0002ev}
Overall, our results show that SIRT7 deficiency leads to replication stress, which has an important impact on genome stability and could contribute to explain the observed progeroid phenotype.
Impaired double‐strand break repair in the absence of SIRT7 {#embj201593499-sec-0005}
-----------------------------------------------------------
Sirtuins participate in the DNA damage response (DDR) by regulating cell cycle progression and DNA repair, particularly non‐homologous end joining (NHEJ) and homologous recombination (HR), which repair DNA DSBs (Jeong *et al*, [2007](#embj201593499-bib-0023){ref-type="ref"}; Yuan *et al*, [2007](#embj201593499-bib-0076){ref-type="ref"}; Li *et al*, [2008](#embj201593499-bib-0029){ref-type="ref"}; McCord *et al*, [2009](#embj201593499-bib-0037){ref-type="ref"}; Kaidi *et al*, [2010](#embj201593499-bib-0024){ref-type="ref"}; Serrano *et al*, [2013](#embj201593499-bib-0058){ref-type="ref"}; Toiber *et al*, [2013](#embj201593499-bib-0067){ref-type="ref"}). Similarly, SIRT7 may participate in the maintenance of genome integrity by modulating DSB repair. To test this, we analyzed 53BP1 chromatin focus formation by IF (Fig [5](#embj201593499-fig-0005){ref-type="fig"}A). 53BP1 is a repair protein that promotes NHEJ by protecting DNA from end resection (Panier & Boulton, [2014](#embj201593499-bib-0048){ref-type="ref"}). We observed a remarkably reduced number of 53BP1 foci per nucleus in the absence of SIRT7 before (Fig [EV3](#embj201593499-fig-0003ev){ref-type="fig"}A) and after inducing DNA damage by IR (Figs [5](#embj201593499-fig-0005){ref-type="fig"}B and [EV3](#embj201593499-fig-0003ev){ref-type="fig"}B). Total 53BP1 protein levels were similar between WT and *SirT7* ^−/−^ cells ([Appendix Fig S3B](#embj201593499-sup-0001){ref-type="supplementary-material"}), suggesting that SIRT7 depletion specifically impacts 53BP1 binding to chromatin. Noticeably, the mean volume of 53BP1 foci per nucleus was reduced in cells from *SirT7* ^−/−^ mice compared with WT (Fig [5](#embj201593499-fig-0005){ref-type="fig"}C). Although 53BP1 facilitation of NHEJ, to the detriment of HR, is plausibly being exerted throughout the cell cycle, 53BP1 also participates in HR‐mediated repair of heterochromatin, which is repaired with slow kinetics as compared with euchromatin (Murray *et al*, [2012](#embj201593499-bib-0042){ref-type="ref"}). However, our data do not support the notion that SIRT7 regulation of 53BP1 recruitment to damaged chromatin affects heterochromatin repair. We did not observe slower repair kinetics of IR‐induced DSBs in SIRT7‐depleted cells (Fig [4](#embj201593499-fig-0004){ref-type="fig"}D), or an accumulation of DNA damage at pericentric heterochromatin (Fig [4](#embj201593499-fig-0004){ref-type="fig"}E and F), as we would expect for a heterochromatin repair impairment. However, we cannot discard that SIRT7 participates in the repair of heterochromatin out of the pericentric regions, such as facultative heterochromatin.
![Impaired NHEJ DNA repair pathway in *SirT7* ^−/−^ cells\
A--EIF analysis of WT and *SirT7* ^−/−^ primary fibroblasts after IR (1 Gy) and 1‐h chase. Cells were pulsed with EdU 30 min prior to fixation, stained with antibodies against γH2AX and 53BP1, and then counterstained with DAPI (scale bar 5 μm). (A) Representative images from each cell cycle stage showing merge (top left) including EdU (green), 53BP1 (top right, magenta), γH2AX (bottom left, red), and 3D rendering of reconstructed Z‐stacks with 53BP1 foci modeled as spheres (bottom right; pale blue: nucleus; magenta spheres: 53BP1 foci). (B) Quantitation of the number of 53BP1 foci per nucleus, and (C) mean volume of 53BP1 foci (*n* \> 30 cells per group/mice; 3 mice per genotype; mean ± SEM). (D, E) Same as in (B, C), upon overexpression of SIRT7 WT or catalytically inactive point mutant SIRT7‐H188Y in WT and *SirT7* ^−/−^ primary fibroblasts.FDetection of endogenous chromatin‐bound and nucleoplasmic 53BP1 protein from WT and *SirT7* ^−/−^ MEFs before and after IR (8 Gy) by Western blot. Histone H3 was used as loading control and tubulin as control for fractionation.GSame as F, using 293T‐REX cells treated with doxycycline or vehicle to |
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18
] | stress (WAS) daily for 10 consecutive days. The abdominal withdrawal reflex (AWR) to colorectal distension was assessed at the end of the 10-day period. Western-blotting analysis was applied to investigate the alterations of TRPV1 and TRPA1 in the colonic afferent dorsal root ganglia (DRG). Compared with control rats, the WAS-treated rats demonstrated a significant increase in the AWR with the pressure > or = 40 mm Hg (P < 0.05). Meanwhile, in the WAS-treated rats, western-blotting analysis showed significant upregulation of TRPV1 and TRPA1 in the colonic afferent DRG. The results indicate that WAS could induce the upregulation of TRPV1 and TRPA1 in the colonic afferent DRG, and both receptors may be candidate molecules involved in the stress-induced visceral hyperalgesia in rats.Connie Morella Visits Law Library on March 18, 2009
Former Maryland Congresswoman Connie Morella Discusses Her Legislative Experience Working for Women, Children and Families
On Wednesday, March 18, acting Law Librarian of Congress Charles Doyle and Associate Librarian of Congress Deanna Marcum will welcome the Honorable Constance ‘Connie’ Morella as she presents “Legislating in Heels – An Anecdotal Journey.” The event will take place between 1:00 and 2:30 pm at the Whittall Pavilion, located in the Jefferson Building on 1st Street SE between Independence Avenue and East Capitol Streets in Washington, D.C.
When she began her lengthy tenure in Congress in 1987, there were only 24 women in the House. Upon her departure 16 years later, that number increased to 62. Her presentation will be a fitting tribute to the accomplishments of women during National Women’s History Month.
Prior to her service as Ambassador to the Organization for Economic Cooperation and Development from 2003 to 2007, Ms. Morella served in Congress, chairing the Congressional Caucus for Women’s Issues and sponsoring the 1992 Battered Women’s Testimony Act and the Judicial Training Act, both having important repercussions for women in the court system due to domestic violence. Ms. Morella also served in the Maryland House of Delegates from the 16th District.
The event is free and open to the public but seating is very limited and advance reservations are suggested at (202) 707-9834, [email protected].
Request ADA accommodations five business days in advance at (202)707-6362 or [email protected]
Founded in 1832, the Law Library of Congress makes its resources available to members of Congress, the Supreme Court, other branches of the U.S. Government and the global legal community, and sustains and preserves a universal collection of law for future generations. With more than 2.6 million volumes, the Law Library contains the world’s largest collection of law books and other resources from all countries and provides online databases and guides to legal information worldwide through its Web site.Mustang Original Studded Seat
Overview of
Mustang Original Studded Seat
Mustang Motorcycle Products, Inc. is a world leader in the design and construction of motorcycle seats. Since 1980, Mustang has been proud of making the highest quality, most comfortable seats available and offering them at reasonable prices. Mustang motorcycle seats are designed for all-day riding comfort for both the driver and passenger. Every Mustang seat is made in the United States by true craftsmen who take pride in transforming the highest quality, raw materials into a finished product.
Full front bucket for comfort
Passenger seat angles forward to support drivers back
Functional skirt flows over frame and fender to give a smooth, clean looktalkingrobocop's podcast
Wherein Kit Power watched the movie Robocop with a different guest each month and records the resulting conversation. Occasional bonus podcasts feature returning guests picking a different movie to watch. Made possible entirely as a result of Patreon funding - www.patreon.com/kitpower. Sign up for only a $1 a month for early access and exclusive content.
Categories
Welcome to the fourth episode of Watching Robocop with Kit Power! This month, I am delighted to be joined by Renee Pickup, a superb author, non-fiction writer, blogger and podcaster with strong opinions and excellent taste in movies. Join us, and discover:
Renee's 'not enough violence in movies' theory
Kill Bill and why you never dis Con Air
An exciting new fan theory about Clarence's nose
And SO much more. Enjoy! And as ever, thank you for your support. :)
For more of Renee's blogging and podcasting, please head on over to her webpage.
My monthly Ginger Nuts Of Horror blog ‘My Life In Horror’, which kicked off this whole thing, can be found here.
Theme tune provided with the kind permission of The Disciples of Gonzo, from their track Superhero. Listen to more from them here.
If you enjoyed this podcast and would like to contribute financially to the monthly production costs, in exchange for early access to both this show and my written work, as well as snazzy exclusives, please see my Patreon.
Welcome to the first ever bonus episode of the podcast! Thanks to the amazing generosity of my Patreon backers, I am going to be releasing these bonus episodes on a bi-monthly basis, in which returning guests get to pick THEIR favourite movie to talk about.
In our first bonus 'cast, Daniel Harper returns to talk about his childhood love affair and obsession with Terminator 2: Judgement Day. Amongst many revelations, discover:
How there are, in fact, only two Terminator movies
Vonnegut's holy word
Kit outing himself as a human chauvinist
And much, much more. Enjoy! :)
For more of Daniel's blogging and podcasting, please head on over to his page on Eruditorum Press.
My monthly Ginger Nuts Of Horror blog ‘My Life In Horror’, which kicked off this whole thing, can be found here.The present invention relates to an improved mounting arrangement for a measuring device of the type comprising a measuring scale, a carrier which supports the measuring scale, and at least one clamping element for fasting the carrier to a mounting surface of one of two objects, the relative position of which is to be measured.
German Pat. No. 27 12 422 discloses a length measuring system which includes a housing that surrounds the measuring scale and the scanning unit. This housing is fastened by means of screws to a machine part.
German Pat. No. 25 05 585 discloses a length measuring system in which a housing, which encloses both the scale and the scanning unit, is fastened at both ends to a machine part by means of angle brackets which define in the vertex region a joint in the form of a groove.
German Pat. No. 26 30 880 discloses a length measuring system in which the housing, which encloses both the scale and the scanning unit, is fastened at both ends to an object to be measured by means of ball joints.
In the measuring systems described above, precisely positioned bores must be provided for the fastening of the housing to the object to be measured, both in the housing and also in the object. The formation of such precise bores represents a considerable expense in many applications.
The document "Messen und Prufen/Automatik", July and August 1974, page 438, FIG. 12a, discloses a known practice for fastening a scale to a narrow supporting surface of a machine part by means of clamping shoes positioned at one side of the scale. In this arrangement high contact pressure forces of the clamping shoes against the scale are needed to hold the scale carrier in engagement on the supporting surface in the face of vibrations and joltings of the machine.
German DE-OS No. 38 08 384 discloses a measuring arrangement in which a scale carrier defines on both side surfaces a lateral groove. Clamping shoes engage this lateral groove in order to fasten the scale carrier to a machine part. This arrangement provides a secure seating of the scale carrier on the machine part, but is relatively expensive in construction and requires considerable space to implement.Molecular analysis of point mutations in a barley genome exposed to MNU and gamma rays.
We present studies aimed at determining the types and frequencies of mutations induced in the barley genome after treatment with chemical (N-methyl-N-nitrosourea, MNU) and physical (gamma rays) mutagens. We created M(2) populations of a doubled haploid line and used them for the analysis of mutations in targeted DNA sequences and over an entire barley genome using TILLING (Targeting Induced Local Lesions in Genomes) and AFLP (Amplified Fragment Length Polymorphism) technique, respectively. Based on the TILLING analysis of the total DNA sequence of 4,537,117bp in the MNU population, the average mutation density was estimated as 1/504kb. Only one nucleotide change was found after an analysis of 3,207,444bp derived from the highest dose of gamma rays applied. MNU was clearly a more efficient mutagen than gamma rays in inducing point mutations in barley. The majority (63.6%) of the MNU-induced nucleotide changes were transitions, with a similar number of G>A and C>T substitutions. The similar share of G>A and C>T transitions indicates a lack of bias in the repair of O(6)-methylguanine lesions between DNA strands. There was, however, a strong specificity of the nucleotide surrounding the O(6)-meG at the -1 |
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] | ') \rvert > \lvert E(H) \rvert$. Denote the four vertices of degree two in $H$ by $\{w,x,y,z\}$. By symmetry, we may assume one of the following holds:
1. Both $wx$ and $yz$ are edges in $H$.
2. $wx$ is an edge in $H$ and $y,z$ are diagonal vertices in a $4$-cycle.
3. $w,x$ are diagonal vertices in a $4$-cycle and $y,z$ are diagonal vertices in another $4$-cycle.
To show that $H'$ has an $(8:3)$-coloring, by Lemma \[extend 8:3\], it is sufficient to show the following. The coloring $f_1$ deals with the case that $H'$ is cubic, and $f_2$ deals with the case that $H'$ is not cubic.
1. If $wx$ and $yz$ are edges, then there are $(8:3)$-colorings $f_1, f_2$ of $H$ such that $f_1(w) \cap f_1(y) = \emptyset$, $f_1(x) \cap f_1(z) = \emptyset$, $f_2(w) \cap f_2(y) = \emptyset$, and $1 \leq \lvert f_2(x) \cap f_2(z) \rvert \leq 2$.
2. If $wx$ is an edge and $y,z$ are diagonal vertices in a $4$-cycle, then there are $(8:3)$-colorings $f_1, f_2$ of $H$ such that $f_1(w) \cap f_1(y) = \emptyset$, $f_1(x) \cap f_1(z) = \emptyset$, $f_2(w) \cap f_2(y) = \emptyset$, $1 \leq \lvert f_2(x) \cap f_2(z) \rvert \leq 2$.
3. If $w,x$ are diagonal vertices in a $4$-cycle and $y,z$ are diagonal vertices in another $4$-cycle, then there are $(8:3)$-colorings $f_1, f_2$ of $H$ such that $f_1(w) \cap f_1(y) = \emptyset$, $f_1(x) \cap f_1(z) = \emptyset$, $f_2(w) \cap f_1(y) = \emptyset$, $1 \leq \lvert f_2(w) \cap f_2(y) \rvert \leq 2$.
The coloring given in Figure \[4 operations\] shows that the patterns of the colors on the pair of adjacent degree-two vertices can be kept if we do Operations 2,1,2,1 consecutively. Hence, it is sufficient to check the above three cases for $1 \leq k \leq 4$. Desired $f_1$ and $f_2$ are shown in Figure \[(8:3)-coloring of L’s\]. Note that the case $k=0$ is excluded by the triangle-freeness of $H'$. Let $G$ be a fractionally $t$-critical triangle-free subcubic graph with $t \geq 8/3$. Suppose that $G$ contains $H'$ as an induced subgraph. If $H'$ is cubic, then $G=H'$ has an $(8:3)$-coloring, a contradiction. If $H'$ is not cubic, then there exist a pair of vertices $u,v$ such that $H'$ is a component of $G-\{u,v\}$. By the nice property of $f_2$ and Lemmas \[2 cut set\] and \[extend 8:3\], $\chi(G)\leq 8/3$, a contradiction.
=0.8mm
(120, 200)(15,-60)
(0,175)[$L_1$]{} (0,155)(12.5,0)[4]{} (18.25,175)(0,-40)[2]{} (0,155)(37,155) (0,155)(18.25,175)(37,155)(18.25,135)(0,155) (11,157)[[$w$]{}]{} (23.5,157)[[$x$]{}]{} (-3,150)[[$123$]{}]{} (9.5,150)[[$456$]{}]{} (22,150)[[$378$]{}]{} (37,150)[[$124$]{}]{} (16,177)[[$567$]{}]{} (16,130)[[$678(568)$]{}]{}
(45,165)(0,-20)[2]{} (18.25,175)(45,165)(45,145)(18.25,135) (47,165)[[$y$]{}]{} (47,145)[[$z$]{}]{} (41,170)[[$238(128)$]{}]{} (41,140)[[$145(347)$]{}]{}
(70,175)[$L_2$]{} (70,155)(12.5,0)[4]{} (88.25,175)(0,-40)[2]{} (70,155)(107,155) (70,155)(88.25,175)(107,155)(88.25,135)(70,155) (87,171)[[$w$]{}]{} (87,137)[[$x$]{}]{} (67,150)[[$123$]{}]{} (79.5,150)[[$456$]{}]{} (92,150)[[$378$]{}]{} (107,150)[[$124$]{}]{} (86,177)[[$567$]{}]{} (86,130)[[$578$]{}]{}
(120,155)(37.5,0)[2]{} (138.75,175)(0,-40)[2]{} (120,155)(138.75,175)(157.5,155)(138.75,135)(120.55,155) (82.5,155)(138.75,175) (95,155)(138.75,135) (118.5,157)[[$y$]{}]{} (156,157)[[$z$]{}]{} (136,177)[[$127$]{}]{} (136,130)[[$125$]{}]{} (117,150)[[$348$]{}]{} (154.75,150)[[$346(348)$]{}]{}
(0,121)[$L_{1,2} \cong L_{2,1}$]{} (0,95)(12.5,0)[4]{} (18.25,115)(0,-40)[2]{} (0,95)(37,95) (0,95)(18.25,115)(37,95)(18.25,75)(0,95) (11,97)[[$w$]{}]{} (23.5,97)[[$x$]{}]{} (-3,90)[[$123$]{}]{} (9.5,90)[[$456$]{}]{} (22,90)[[$378$]{}]{} (37,90)[[$124$]{}]{} (16,117)[[$567$]{}]{} (16,70)[[$678(568)$]{}]{}
(45,105)(0,-20)[2]{} (18.25,115)(45,105)(45,85)(18.25,75) (39,109)[[$238(128)$]{}]{} (39,79.5)[[$145(347)$]{}]{}
(52.5,95)(37.5,0)[2]{} (70.75,115)(0,-40)[2]{} (52.5,95)(70.75,115)(90,95)(70.75,75)(52.5,95) (45,105)(70.75,115) (45,85)(70.75,75) (51,98)[[$y$]{}]{} (89,98)[[$z$]{}]{} (49.5,90.5)[[$123$]{}]{} (48.5,87.5)[[$(138)$]{}]{} (89,90.5)[[$124$]{}]{} (87.5,87.5)[[$(148)$]{}]{} (68,117)[[$567$]{}]{} (68,70)[[$678(256)$]{}]{}
(100,121)[$L_{1,2,1}$]{} (100,95)(12.5,0)[4]{} (118.25,115)(0,-40)[2]{} (100,95)(137,95) (100,95)(118.25,115)(137,95)(118.25,75)(100,95) (111,97)[[$w$]{}]{} (123.5,97)[[$x$]{}]{} (97,90)[[$123$]{}]{} (109.5,90)[[$456$]{}]{} (122,90)[[$378$]{}]{} (137,90)[[$124$]{}]{} (116,117)[[$567$]{}]{} (116,70)[[$568$]{}]{}
(145,105)(0,-20)[2]{} (118.25,115)(145,105)(145,85)(118.25,75) (142,109)[[$128$]{}]{} (142,80)[[$347$]{}]{}
(152.5,95)(12.5,0)[4]{} (170.75,115)(0,-40)[2]{} (152.5,95)(190,95) (152.5,95)(170.75,115)(190,95)(170.75,75 |
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] | *j + 49, 0 = 5*s - 4 - 11. Suppose -10 = 3*d + 20. Let z = d + j. What is the units digit of z?
6
Let l(d) = -d**3 - 2*d**2 - 3*d - 10. What is the tens digit of l(-6)?
5
Let f be 15 + 1 + 6 + -6. Let r = 6 + f. What is the units digit of r?
2
Let u be 3*1/(6/20). What is the units digit of (-1599)/(-65) - (-4)/u?
5
Let m(c) be the first derivative of c**2 - 6*c + 1. Let i be (-5)/((-9)/(-3) + -4). What is the units digit of m(i)?
4
What is the tens digit of (-1 + 43)*(0 + (-9)/(-6))?
6
Suppose 0 = o + 3*i - 11, 0*i = 4*i - 8. Let b = 10 - o. Suppose 4*p - 6 = 2*n - 46, b*n = -4*p + 72. What is the tens digit of n?
1
Let g(v) = 13 + v**2 - 6*v - 3 - 3. Let j(a) = 5*a**3 + a**2 + a - 2. Let b be j(1). What is the units digit of g(b)?
2
Let h(v) be the first derivative of -v**3/3 + v**2/2 - v - 1. Let c be h(0). Let t = c - -9. What is the units digit of t?
8
Let j(r) = r**2 - 7*r + 8. Let l be j(6). Suppose 0 = l*t + 8. What is the units digit of (-2 - t) + -1 - -5?
6
Suppose 4*i + 45 = r + 126, -3*i + 65 = -5*r. Suppose -b = b - i. What is the tens digit of b?
1
Let p be 2/2 - (-2 + -57). Let c = p + -33. What is the tens digit of c?
2
Suppose 0*j = -j + 38. What is the units digit of j?
8
Let t = -10 + 14. Let o(c) = -c**3 + 7*c**2 - 5*c - 4. What is the units digit of o(t)?
4
Suppose -408 + 156 = -6*n. What is the tens digit of n?
4
What is the tens digit of 9/(-3) - (-36 + 1)?
3
Let i(j) = -j**2 - j - 9. Let y be i(0). Let d be 8/36 + 56/y. Let u(m) = -m**2 - 10*m - 6. What is the units digit of u(d)?
8
Let q = 8 + 0. What is the tens digit of (-2)/(q/(-52)) - -1?
1
Let f = -1 - 0. What is the tens digit of 3/(((-6)/28)/f)?
1
Suppose 0*y = 4*y - 160. Let i(f) = 0*f + y - f - 21. What is the tens digit of i(9)?
1
Let p(y) = 4*y**2 - 1. Let l be p(-1). Suppose -2*z + 3*a = -2, l*a = 3*z - 8*z - 37. Let k = z + 7. What is the units digit of k?
2
Suppose 0 = -5*r + 18 + 7. Suppose -10*z = -5*z - r. What is the units digit of z?
1
Let f be -3 - (6/(-3) - -5). Let s = f - -27. What is the tens digit of s?
2
Let k(b) = b**3 - b**2 - b + 1. Let p be k(2). Suppose 3*f - p*n = 30 + 39, -3*n + 120 = 4*f. What is the tens digit of f?
2
Suppose 3*u - u = 0. Let m be (10/1)/(2 - u). Suppose 3*h + m - 20 = 0. What is the units digit of h?
5
Let f(m) = -m**3 - 4*m**2 + 5*m. Let b be f(-5). Suppose -5*h + b*h + 25 = 0. Suppose 0 = h*k + 1 - 11. What is the units digit of k?
2
Suppose 0 = -12*x + 8*x + 32. What is the units digit of x?
8
Suppose -2*v + 0*v = -2. Let i = v + 7. What is the units digit of i?
8
Let z = 741 + -504. What is the tens digit of z?
3
Suppose 2*u = 7*u - 85. Suppose 4*q = 0, -u = -2*k - 4*q + 3. What is the tens digit of k?
1
Suppose 61 = 2*t - 1. What is the tens digit of t?
3
Let h(i) = -i**3 - 7*i**2 - 4*i + 2. Let a be h(-6). Let x(z) = -z**3 - 10*z**2 + 4. What is the units digit of x(a)?
4
Suppose -24 = -2*r + 5*m - 0*m, -5*m - 18 = r. Suppose -r*h = 2*h - 84. What is the units digit of h?
1
Let r(y) = -5*y**2 - y - 4. Let d be r(4). Let m = d - -148. Suppose 7*x = 4*x + m. What is the units digit of x?
0
Let s(m) be the first derivative of 2*m + 1/2*m**2 + 1 + 1/4*m**4 - 2/3*m**3. What is the units digit of s(2)?
4
What is the units digit of 100/(-40)*(-356)/10?
9
Let y be (-2 - 1)*(-46)/(-6). Let s = y + 32. Suppose 0 = -5*l - 4*u + 88, -4*l + 3*u - s + 67 = 0. What is the tens digit of l?
1
Suppose -17 - 93 = 5*i. What is the units digit of 1/(-2)*i*1?
1
Let h(i) = i**3 + 7*i**2 + 5*i + 5. What is the tens digit of h(-6)?
1
Let c = 44 + -22. What is the units digit of c?
2
Suppose g - 3*i - 8 = -1, 5*g + 22 = -4*i. Let h = 2 - g. Suppose 5*n + 3*b = -b + 14, h*b - 6 = -n. What is the units digit of n?
2
Suppose 8*x - 7*x - 116 = 0. What is the tens digit of x?
1
Let p(z) = -z + 8. Let x be (-1)/(-3) + (-4)/(-6). Let w be 2*(x + 33/(-6))2019 Virginia Travel Guide and State Map
Dining
The Tides Inn Dining
Let our culinary team enhance your distinct palate as you sample the best in authentic regional cuisine. Chesapeake Restaurant offers a casual yet refined dining experience to all of our guests while emphasizing the concept of tide to table; however, we remain true to some of our Southern traditions. Dramatic views of the Tides Marina and Carters Creek frame your dining experience. Chesapeake Restaurant offers a Wine Spectator accredited extensive wine list. While enjoying picturesque views of the creek, have lunch at Commodore’s. After a round of golf, enjoy light fare at the Golden Eagle Grill. We offer an eclectic range of dining experiences in unique settings, satisfying diverse palates.Q:
ASP Session variables: Is "" same as IsEmpty?
In ASP an uninitialized Session variable Is Empty. I know that the correct way to check for a Session value, and remove a value, is the following:
IF NOT IsEmpty(Session("myVar")) THEN
' Go ahead and use Session("myVar")
...
' Now if we're all done with myVar then remove it:
Session.Contents.Remove("myVar")
END IF
I've inherited a codebase where Application and Session variables are typically set = "" after use, and all tests for a value are of the form (Sessions("myVar") = ""). This test appears to work when the Session variable has not been declared ... or maybe it's just working by dumb luck.
|
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] | Materials and Methods {#s2}
=====================
Reagents {#s2a}
--------
MI-63 and MI-219 were provided by Sanofi (Bridgewater, NJ), while ABT-737, bortezomib, and lenalidomide were purchased from Selleck Chemicals (Houston, TX).
Chloroquine and 3-methyladenine were purchased from Sigma-Aldrich (St. Louis, MO).
Tissue culture and patient samples {#s2b}
----------------------------------
Myeloma cell lines were purchased either from the German Collection of Microorganisms and Cell Cultures (Braunschweig, Germany), or the American Type Culture Collection (Manassas, VA), and validated by the MD Anderson Characterized Cell Line Core Facility. Primary samples were from patients who had provided written informed consent in compliance with the Declaration of Helsinki according to an MD Anderson Institutional Review Board 5 approved protocol (LAB11-0321). CD138^+^ or ^−^ cells were isolated from these fresh bone marrow aspirates with the CD138 Positive Plasma Cell Isolation Kit (Miltenyi Biotec; Auburn, CA). Cells were cultured in RPMI 1640 medium with 2 mM L-glutamine (Invitrogen; Carlsbad, CA) supplemented with 10% fetal bovine serum (Sigma-Aldrich), 100 U/mL penicillin (Invitrogen) and 100 µg/ml streptomycin (Invitrogen). HS-5 stromal cells from the American Type Culture Collection were cultured in Dulbecco\'s modified Eagle\'s medium containing fetal bovine serum and penicillin and streptomycin as above.
Cell viability assays {#s2c}
---------------------
Cell viability was determined using the tetrazolium reagent WST-1 (Roche Applied Science; Indianapolis, IN) according to the manufacturer\'s instructions and as previously described [@pone.0103015-Jones1]. Viability curves were fitted in GraphPad Prism version 6 (La Jolla, CA) and median inhibitory concentrations (IC~50~) were calculated using log (inhibitor) vs. response -- variable slope (four parameters).
shRNA gene knockdown {#s2d}
--------------------
Lentiviral constructs containing non-targeting shRNA sequences, or shRNAs designed to suppress expression of MDM2, p53, autophagy (ATG)-related protein 5 (ATG5) and Beclin-1 were purchased from Sigma-Aldrich. Viral particles were generated from 293T cells following standard protocols, and myeloma cells were infected and selected with the use of polybrene and puromycin, as detailed previously [@pone.0103015-Kuhn1].
Reverse transcription and quantitative PCR {#s2e}
------------------------------------------
Total RNA was extracted using Trizol (Invitrogen), and cDNA was synthesized with High-Capacity cDNA Reverse Transcription Kits (Applied Biosystems; Grand Island, NY) as previously described [@pone.0103015-Yang1]. TaqMan Gene Expression Master Mix and probes were purchased from Applied Biosystems and used to perform quantitative PCR (qPCR) reactions on an Applied Biosystems StepOnePlus Real-Time PCR system. Expression of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was used as an internal control.
Proteomic assays {#s2f}
----------------
Western blotting and immunoprecipitation of protein extracts was performed using standard procedures [@pone.0103015-Jones2]. Antibodies which were used included: anti-p53 (DO-1) and Bax (6A7)(Santa Cruz Biotechnology; Santa Cruz, CA); anti-MDM2 (Ab-1) and -Bak (Ab-1)(Calbiochem; San Diego, CA); anti-Caspase-3 (5A1E), -9 (D2D4), -poly ADP ribose polymerase (PARP)(D64E10), -p53 upregulated modulator of apoptosis (PUMA)(D30C10), -Microtubule-associated protein 1 light chain 3 (LC3)(D3U4C & D11), -Cytochrome C (136F3), -Beclin-1 (\#3738) and -ATG5 (\#2630)(Cell Signaling Technology; Danvers, MA); and anti-Actin (A2066)(Sigma-Aldrich). Densitometry was performed using ImageJ software version 1.46 (National Institute of Health; Bethesda, MD). Mitochondrial isolation prior to Western blotting was performed where indicated using the Mitochondria Isolation Kit (Thermo Scientific; Rockford, IL). Reverse phase protein array (RPPA) analyses were performed by the MD Anderson Cancer Center RPPA/Functional Proteomics Core Facility.
Cell cycle analysis and apoptosis {#s2g}
---------------------------------
Cell cycle analysis was performed by staining with propidium iodide (Sigma-Aldrich), and then analyzing cells by flow cytometry as described previously [@pone.0103015-Bjorklund1]. Annexin V staining was used to detect apoptosis by flow cytometry using the manufacturer\'s instructions (Invitrogen).
Drug synergy calculations and statistical analyses {#s2h}
--------------------------------------------------
Data were analyzed using CalcuSyn software (Biosoft; Cambridge, United Kingdom), and combination indices (CI) were calculated to determine if synergistic interactions were being observed. Statistical analyses were performed with unpaired *t* tests in GraphPad, and *p*-values less than 0.05 were judged to be significant.
Xenograft model {#s2i}
---------------
Experiments were performed in accordance with procedures and protocols approved by the MD Anderson Cancer Center Animal Care and Use Committee using xenografts developed as detailed previously [@pone.0103015-Jones1], [@pone.0103015-Bjorklund2]. In brief, 10^7^ MM1.S cells were inoculated subcutaneously in 6-week-old nonobese diabetic severe combined immunodeficiency (NOD/SCID) gamma mice (The Jackson Laboratory; Bar Harbor, ME) to establish tumors. Vehicle (10% polyethylene glycol, 3% Cremophor EL in phosphate buffered saline) or MI-219 (100 mg/kg) was injected intraperitoneally three times a week. Tumor diameters were measured with a digital caliper, and tumor volume was calculated by the formula: volume = (width)^2^×length/2.
Results {#s3}
=======
MDM2 inhibition with MI-63 is cytotoxic to wild-type p53 myeloma cells {#s3a}
----------------------------------------------------------------------
Nutlin-based inhibitors of MDM2 have been found to have activity predominantly against wild-type (wt) p53 myeloma models. To evaluate the activity of MI-63, we exposed a panel of wt p53 myeloma cell lines (MM1.S, H929, MOLP-8) to this agent, and measured viability with a tetrazolium reagent. All of these cell lines were found to be very sensitive to low drug levels over the course of a 48-hour exposure ([Figure 1A](#pone-0103015-g001){ref-type="fig"}), with a median inhibitory concentration (IC~50~) in the low single µM range or less (MM1.S: 0.6 µM; H929: 0.4 µM; MOLP-8: 1.5 µM). In order to verify that MI-63 was indeed inhibiting the interaction between MDM2 and p53, we subjected extracts of MM1.S cells to immunoprecipitation with an anti-MDM2 antibody, and then analyzed these by Western blotting. Compared to vehicle-treated controls, the level of p53 immunoprecipitated in association with MDM2 was reduced after these cells were treated with MI-63 ([Figure 1B](#pone-0103015-g001){ref-type="fig"}). In comparison, MI-63 did not alter the interaction with MDM4, which associates with MDM2 through the RING finger domain ([Figure S1](#pone.0103015.s001){ref-type="supplementary-material"}) [@pone.0103015-Tanimura1]. We then prepared MM1.S cells in which p53 expression had been stably suppressed at the mRNA ([Figure S2A](#pone.0103015.s002){ref-type="supplementary-material"}) and protein levels ([Figure S2B](#pone.0103015.s002){ref-type="supplementary-material"}) using a Lentiviral-delivered small hairpin (sh) RNA construct. MI-63 retained activity against MM1.S cells harboring a non-targeting shRNA construct ([Figure 1C](#pone-0103015-g001){ref-type="fig"}), but this was substantially blunted in the cells with decreased p53 content (control shRNA IC~50~: 2.2 µM; p53 shRNA IC~50~: 5.2 µM), consistent with a strong impact of p53 status. Finally, since microenvironmental effects, such as expression of interleukin (IL)-6, may modulate the expression of p53 [@pone.0103015-Hodge1], we evaluated the activity of MI-63 on myeloma cells in the presence of HS-5 human stromal cells. When MM1.S cells were co-cultured with stromal cells, the IC~50~ of MI-63 was not significantly altered (MM1.S+HS-5 IC~50~: 1.9 µM; MM1.S IC~50~: 3.4 µM) ([Figure 1D](#pone-0103015-g001){ref-type="fig"}), and similar data were obtained in MOLP-8 cells (control shRNA IC~50~: 3.5 µM; p53 shRNA IC~50~: 3.5 µM; |
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] |
'__builtin_ia32_cmpngess': '_mm_cmpnge_ss',
'__builtin_ia32_cmpordss': '_mm_cmpord_ss',
'__builtin_ia32_movss': '_mm_move_ss',
'__builtin_ia32_movsd': '_mm_move_sd',
'__builtin_ia32_movhlps': '_mm_movehl_ps',
'__builtin_ia32_movlhps': '_mm_movelh_ps',
'__builtin_ia32_movqv4si': '_mm_move_epi64',
'__builtin_ia32_unpckhps': '_mm_unpackhi_ps',
'__builtin_ia32_unpckhpd': '_mm_unpackhi_pd',
'__builtin_ia32_punpckhbw128': '_mm_unpackhi_epi8',
'__builtin_ia32_punpckhwd128': '_mm_unpackhi_epi16',
'__builtin_ia32_punpckhdq128': '_mm_unpackhi_epi32',
'__builtin_ia32_punpckhqdq128': '_mm_unpackhi_epi64',
'__builtin_ia32_unpcklps': '_mm_unpacklo_ps',
'__builtin_ia32_unpcklpd': '_mm_unpacklo_pd',
'__builtin_ia32_punpcklbw128': '_mm_unpacklo_epi8',
'__builtin_ia32_punpcklwd128': '_mm_unpacklo_epi16',
'__builtin_ia32_punpckldq128': '_mm_unpacklo_epi32',
'__builtin_ia32_punpcklqdq128': '_mm_unpacklo_epi64',
'__builtin_ia32_cmpeqpd': '_mm_cmpeq_pd',
'__builtin_ia32_cmpltpd': '_mm_cmplt_pd',
'__builtin_ia32_cmplepd': '_mm_cmple_pd',
'__builtin_ia32_cmpgtpd': '_mm_cmpgt_pd',
'__builtin_ia32_cmpgepd': '_mm_cmpge_pd',
'__builtin_ia32_cmpunordpd': '_mm_cmpunord_pd',
'__builtin_ia32_cmpneqpd': '_mm_cmpneq_pd',
'__builtin_ia32_cmpnltpd': '_mm_cmpnlt_pd',
'__builtin_ia32_cmpnlepd': '_mm_cmpnle_pd',
'__builtin_ia32_cmpngtpd': '_mm_cmpngt_pd',
'__builtin_ia32_cmpngepd': '_mm_cmpnge_pd',
'__builtin_ia32_cmpordpd': '_mm_cmpord_pd',
'__builtin_ia32_cmpeqsd': '_mm_cmpeq_sd',
'__builtin_ia32_cmpltsd': '_mm_cmplt_sd',
'__builtin_ia32_cmplesd': '_mm_cmple_sd',
'__builtin_ia32_cmpunordsd': '_mm_cmpunord_sd',
'__builtin_ia32_cmpneqsd': '_mm_cmpneq_sd',
'__builtin_ia32_cmpnltsd': '_mm_cmpnlt_sd',
'__builtin_ia32_cmpnlesd': '_mm_cmpnle_sd',
'__builtin_ia32_cmpordsd': '_mm_cmpord_sd',
'__builtin_ia32_cvtsi642ss': '_mm_cvtsi64_ss',
'__builtin_ia32_cvttss2si64': '_mm_cvtss_si64',
'__builtin_ia32_shufps': '_mm_shuffle_ps',
'__builtin_ia32_shufpd': '_mm_shuffle_pd',
'__builtin_ia32_pshufhw': '_mm_shufflehi_epi16',
'__builtin_ia32_pshuflw': '_mm_shufflelo_epi16',
'__builtin_ia32_pshufd': '_mm_shuffle_epi32',
'__builtin_ia32_movshdup': '_mm_movehdup_ps',
'__builtin_ia32_movsldup': '_mm_moveldup_ps',
'__builtin_ia32_maxps': '_mm_max_ps',
'__builtin_ia32_pslldi128': '_mm_slli_epi32',
'__builtin_ia32_vec_set_v16qi': '_mm_insert_epi8',
'__builtin_ia32_vec_set_v8hi': '_mm_insert_epi16',
'__builtin_ia32_vec_set_v4si': '_mm_insert_epi32',
'__builtin_ia32_vec_set_v2di': '_mm_insert_epi64',
'__builtin_ia32_vec_set_v4hi': '_mm_insert_pi16',
'__builtin_ia32_vec_ext_v16qi': '_mm_extract_epi8',
'__builtin_ia32_vec_ext_v8hi': '_mm_extract_epi16',
'__builtin_ia32_vec_ext_v4si': '_mm_extract_epi32',
'__builtin_ia32_vec_ext_v2di': '_mm_extract_epi64',
'__builtin_ia32_vec_ext_v4hi': '_mm_extract_pi16',
'__builtin_ia32_vec_ext_v4sf': '_mm_extract_ps'
}
# Special unhandled cases:
# __builtin_ia32_vec_ext_*(__P, idx) -> _mm_store_sd/_mm_storeh_pd
# depending on index. No abstract insert/extract for these oddly.
unhandled = [
'__builtin_ia32_vec_ext_v2df',
'__builtin_ia32_vec_ext_v2si',
]
def report_repl(builtin, repl):
sys.stderr.write("%s:%d: x86 builtin %s used, replaced with %s\n" % (fileinput.filename(), fileinput.filelineno(), builtin, repl))
def report_cant(builtin):
sys.stderr.write("%s:%d: x86 builtin %s used, too many replacements\n" % (fileinput.filename(), fileinput.filelineno(), builtin))
for line in fileinput.input(inplace=1):
for builtin, repl in repl_map.iteritems():
if builtin in line:
line = line.replace(builtin, repl)
report_repl(builtin, repl)
for unh in unhandled:
if unh in line:
report_cant(unh)
sys.stdout.write(line)
sys.exit(err)
After sinking over 60 percent from its December high to its February low, bitcoin is showing signs of life.
The cryptocurrency is now up about 35 percent since it sank below $6,900 on Feb. 5, and one market watcher who correctly called the rally says there's even more room to run.
After the Feb. 5 low, Blue Line Futures President Bill Baruch told CNBC's "Trading Nation" he saw a move up back up to $10,000. At that time, bitcoin was trading around $7,200. Tuesday morning, bitcoin was trading above $9,200, representing roughly 28 percent upside since that time. Here's his latest bull case.
• Participation in the rally has been broad-based, with several so-called alt-coins gaining in value recently. This is seen as a bullish catalyst for the entire cryptocurrency space.
• Bitcoin has seen a bounce from its 2018 lows even in the face of ongoing regulatory concerns, including a new inquiry from New York Attorney General Eric Schneiderman into exchanges like Gemini and Coinbase's GDAX exchange.
• The $10,000 level has represented strong resistance, but once that level is breached to the upside, Baruch sees a trade around $11,500 per coin.
Bottom line: Baruch sees further upside for bitcoin after a sizable rally from its 2018 lows.I just had my first MRI in April and I |
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] | — 10 years before the start of the Great Depression in 1919, when they independently warned that going back on the gold standard at the post-World War I price level (in terms of gold) — about twice the pre-War price level — would cause a disastrous deflation unless the world’s monetary authorities took concerted action to reduce the international monetary demand for gold as countries went back on the gold standard to a level consistent with the elevated post-War price level. The Genoa Monetary Conference of 1922, inspired by the work of Hawtrey and Cassel, resulted in an agreement (unfortunately voluntary and non-binding) that, as countries returned to the gold standard, they would neither reintroduce gold coinage nor keep their monetary reserves in the form of physical gold, but instead would hold reserves in dollar or (once the gold convertibility of sterling was restored) pound-denominated assets. (Ron Batchelder and I have a paper discussing the work of Hawtrey and Casssel on the Great Depression; Doug Irwin has a paper discussing Cassel.)
After the short, but fierce, deflation of 1920-21 (see here and here), when the US (about the only country in the world then on the gold standard) led the world in reducing the price level by about a third, but still about two-thirds higher than the pre-War price level, the Genoa system worked moderately well until 1928 when the Bank of France, totally defying the Genoa Agreement, launched its insane policy of converting its monetary reserves into physical gold. As long as the US was prepared to accommodate the insane French gold-lust by permitting a sufficient efflux of gold from its own immense holdings, the Genoa system continued to function. But in late 1928 and 1929, the Fed, responding to domestic fears about a possible stock-market bubble, kept raising interest rates to levels not seen since the deflationary disaster of 1920-21. And sure enough, a 6.5% discount rate (just shy of the calamitous 7% rate set in 1920) reversed the flow of gold out of the US, and soon the US was accumulating gold almost as rapidly as the insane Bank of France was.
This was exactly the scenario against which Hawtrey and Cassel had been warning since 1919. They saw it happening, and watched in horror while their warnings were disregarded as virtually the whole world plunged blindly into a deflationary abyss. Keynes had some inkling of what was going on – he was an old friend and admirer of Hawtrey and had considerable regard for Cassel – but, for reasons I don’t really understand, Keynes was intent on explaining the downturn in terms of his own evolving theoretical vision of how the economy works, even though just about everything that was happening had already been foreseen by Hawtrey and Cassel.
More than a quarter of a century after the fact, and after the Keynesian Revolution in macroeconomics was well established, along came Friedman, woefully ignorant of pre-Keynesian monetary theory, but determined to show that the Keynesian explanation for the Great Depression was wrong and unnecessary. So Friedman came up with his own explanation of the Great Depression that did not even begin until December 1930 when the Fed allowed the Bank of United States to fail, triggering, in Friedman’s telling, a wave of bank failures that caused the US money supply to decline by a third by 1933. Rather than see the Great Depression as a global phenomenon caused by a massive increase in the world’s monetary demand for gold, Friedman portrayed it as a largely domestic phenomenon, though somehow linked to contemporaneous downturns elsewhere, for which the primary explanation was the Fed’s passivity in the face of contagious bank failures. Friedman, mistaking the epiphenomenon for the phenomenon itself, ignorantly disregarded the monetary theory of the Great Depression that had already been worked out by Hawtrey and Cassel and substituted in its place a simplistic, dumbed-down version of the quantity theory. So Friedman reinvented the wheel, but did a really miserable job of it.
A. C. Pigou, Alfred Marshall’s student and successor at Cambridge, was a brilliant and prolific economic theorist in his own right. In his modesty and reverence for his teacher, Pigou was given to say “It’s all in Marshall.” When it comes to explaining the Great Depression, one might say as well “it’s all in Hawtrey.”
So I agree that Delong is totally justified in criticizing Friedman and his followers for giving such a silly explanation of the Great Depression, as if it were, for all intents and purposes, made in the US, and as if the Great Depression didn’t really start until 1931. But the problem with Friedman is not, as Delong suggests, that he distracted us from the superior insights of Keynes and Minsky into the causes of the Great Depression. The problem is that Friedman botched the monetary theory, even though the monetary theory had already been worked out for him if only he had bothered to read it. But Friedman’s interest in the history of monetary theory did not extend very far, if at all, beyond an overrated book by his teacher Lloyd Mints A History of Banking Theory.
As for whether fiscal expansion called for by Keynes was necessary to end the Great Depression, we do know that the key factor explaining recovery from the Great Depression was leaving the gold standard. And the most important example of the importance of leaving the gold standard is the remarkable explosion of output in the US beginning in April 1933 (surely before expansionary fiscal policy could take effect) following the suspension of the gold standard by FDR and an effective 40% devaluation of the dollar in terms of gold. Between April and July 1933, industrial production in the US increased by 70%, stock prices nearly doubled, employment rose by 25%, while wholesale prices rose by 14%. All that is directly attributable to FDR’s decision to take the US off gold, and devalue the dollar (see here). Unfortunately, in July 1933, FDR snatched defeat from the jaws of victory (or depression from the jaws of recovery) by starting the National Recovery Administration, whose stated goal was (OMG!) to raise prices by cartelizing industries and restricting output, while imposing a 30% increase in nominal wages. That was enough to bring the recovery to a virtual standstill, prolonging the Great Depression for years.
I don’t say that the fiscal expansion under FDR had no stimulative effect in the Great Depression or that the fiscal expansion under Obama in the Little Depression had no stimulative effect, but you can’t prove that monetary policy is useless just by reminding us that Friedman liked to assume (as if it were a fact) that the demand for money is highly insensitive to changes in the rate of interest. The difference between the rapid recovery from the Great Depression when countries left the gold standard and the weak recovery from the Little Depression is that leaving the gold standard had an immediate effect on price-level expectations, while monetary expansion during the Little Depression was undertaken with explicit assurances by the monetary authorities that the 2% inflation target – in the upper direction, at any rate — was, and would forever more remain, sacred and inviolable.
In his latest blog post Paul Krugman drew my attention to Keynes’s essay The Great Slump of 1930. In describing the enormity of the 1930 slump, Keynes properly compared the severity of the 1930 slump with the 1920-21 episode, noting that the price decline in 1920-21 was of a similar magnitude to that of 1930. James Grant, in his book on the Greatest Depression, argues that the Greatest Depression was so outstanding, because, in contrast to the Great Depression, there was no attempt by the government in 1920-21 to cushion the blow. Instead, the powers that be just stood back and let the devil take the hindmost.
Keynes had a different take on the difference between the Greatest Depression and the Great Depression:
First of all, the extreme violence of the slump is to be noticed. In the three leading industrial countries of the world—the United States, Great Britain, and Germany—10,000,000 workers stand idle. There is scarcely an important industry anywhere earning enough profit to make it expand—which is the test of progress. At the same time, in the countries of primary production the output of mining and of agriculture is selling, in the case of almost every important commodity, at a price which, for many or for the majority of producers, does not cover its cost. In 1921, when prices fell as heavily, the fall was from a boom level at which producers were making abnormal profits; and there is no example in modern history of so great and rapid a fall of prices from a normal figure as has occurred in the past year. Hence the magnitude of the catastrophe.
In diagnosing what went wrong in the Great Depression, Keynes largely, though not entirely, missed the most important cause of the catastrophe, the appreciation of gold caused by the attempt to restore an international gold standard without a means by which to control the monetary demand for gold of the world’s central banks — most notoriously, the insane Bank of France. Keynes should have paid more attention to Hawtrey and Cassel than he did. But Keynes was absolutely on target in explaining why the world more easily absorbed and recovered from a 40% deflation in 1920-21 than it was able to do in 1929-33.
Commenter TravisV kindly referred me to a review article by David Frum in the current issue of the Atlantic Monthly of The Delugeby Adam Tooze, an economic history of the First World War, its aftermath, and the rise of America as the first global superpower since the Roman Empire. |
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] | . Gently place on the grill directly over the fire and grill, turning once, for about 2 minutes per side, until juicy and cooked to medium.
While the kofta are cooking, mix together the spinach, cabbage, fennel, red onion, almonds, dates, dill, and feta in a large bowl. Season with salt and pepper and lightly dress with the vinaigrette. Divide the salad among four plates and top with the kofta, dividing them evenly. Serve immediately.
OTHER GREENS TO TRY Belgian endive, mâche, red orach, tatsoi
CHALLAH FATTOUSH WITH SPINACH, TOMATOES, CUCUMBER, DILL, MINT, AND OREGANO
_Fattoush_ is a Middle Eastern salad that features toasted pita in the mix. This version uses challah instead of pita, a substitution I came up with because I had some leftover challah from the Jewish holidays. There is a heavy herbal taste in this version, thanks not only to the dill, basil, oregano, and mint but also to the cucumbers. The flavors feel perfectly Middle Eastern, savory and bright and fresh, with a hint of sour from the sumac vinaigrette.
SERVES 2 TO 4
8 ounces [230 g] challah, torn into 1- to 2-inch [2.5- to 5-cm] pieces
8 ounces [230 g] cherry tomatoes, halved
4 ounces [115 g] Persian or English cucumber, quartered lengthwise and thinly sliced crosswise
2 green onions, cut into 1-inch [2.5-cm] batons
1 small red bell pepper, seeded and thinly sliced
2 ounces [55 g] spinach leaves
4 dill fronds, fine leaves coarsely chopped and thick stems discarded
12 fresh basil leaves, cut into ¼-inch [6-mm] ribbons
12 fresh mint leaves, cut into ¼-inch [6-mm] ribbons
3 sprigs oregano, leaves removed and tougher stems discarded
2 ounces [55 g] feta cheese, finely crumbled
Fine sea salt
Sumac vinaigrette
Preheat the oven to 350°F [180°C].
Spread the challah pieces on a sheet pan. Bake until mostly dried and lightly golden, about 15 minutes. Remove from the oven and cool completely.
Combine the tomatoes, cucumber, green onions, bell pepper, spinach, dill, basil, mint, oregano, and feta in a large bowl. Season with salt and dress with the vinaigrette. Add the challah and toss until evenly coated, then divide among plates and serve immediately.
OTHER GREENS TO TRY arugula, tatsoi
ASPARAGUS AND SPINACH HUMMUS
Sometimes spinach can be essential to a dish without being the spotlight ingredient. This recipe is the perfect example of using spinach for color and nutrition but not the dominant flavor. It was inspired by an asparagus soup that I make: I cool it down and then add pureed spinach to brighten the color. I use that same approach with this hummus recipe, which tastes like asparagus and is a beautiful green because of the spinach.
MAKES 3 PINTS [1.5 L]
1 rounded cup [230 g] dried chickpeas
6 cups [1.4 L] water
8-inch [20-cm] sprig rosemary
2 bay leaves
14 ounces [400 g] tender parts asparagus or trim from peeling asparagus (after woody bottoms are discarded)
½ cup plus 3 tablespoons [170 g] tahini
3 cloves garlic
5 ounces [140 g] spinach
1 cup [240 ml] olive oil
6 tablespoons [90 ml] fresh lemon juice
1½ tablespoons kosher salt
Put the chickpeas in a large bowl and add water to cover by 3 inches [7.5 cm]. Soak overnight at room temperature.
The following day, drain the beans and transfer to a saucepan. Add the water, rosemary, and bay leaves; bring to a simmer; and cook until the chickpeas are very tender, about 45 minutes. Add the asparagus and continue to cook, stirring often, until the asparagus is tender, about 10 minutes. Remove from the heat and cool completely at room temperature.
Drain the chickpeas and asparagus. Working in batches, transfer the chickpea mixture to a high-powered blender (such as a Vitamix Vita-Prep) and puree with the tahini, garlic, spinach, and olive oil. When each batch is smooth, pass it through a fine-mesh sieve into a large bowl. When all of the batches have been strained, add the lemon juice and salt and stir well to blend the seasonings evenly.
Serve immediately or store in one or more airtight containers in the refrigerator for up to 1 week.
OTHER GREENS TO TRY mâche, New Zealand spinach
SUCCULENTS
A familiar sight throughout the American Southwest, succulents such as various cacti, aloe, and others are not only beautiful natives of the landscape but also lovely additions to a dinner plate. Cacti, for example, are thought to have been part of the terrain for as long as seven thousand years, as evidenced by fossils found in Mexico. The Spaniards, likely thanks to Christopher Columbus, started eating succulents in the late fifteenth or early sixteenth century and then spread the wealth to the Middle East via trade. Today, succulents such as cactus paddles, agave, aloe, and dragonfruit are becoming more common at farmers' markets and groceries. Succulents are distinguished by their fleshy stems and/or leaves, and when cooked, they release a sap much the way okra does. High in vitamin C, fiber, and magnesium, succulents may also contain a fair amount of potassium and calcium.
VARIETIES AGAVE, ALOE, BARREL, DRAGONFRUIT, HENS AND CHICKS, NOPALES, ORCHID, ORGAN PIPE, PRICKLY PEAR, PURSLANE, SAGUARO, SEDUM
SEASON Spring
HOW TO CHOOSE Look for plants that are vibrant green and sturdy, with no black spots. Though the texture will be pliant when squeezed, succulents should not be mushy or limp.
HOW TO CLEAN Wear plastic gloves when handling thorny succulents to prevent being pricked! Rinse thoroughly under cold water. Then, with a vegetable peeler or knife, peel away bumps and thorns. Trim off about one-quarter of the border around the edges, then rinse again. (Thorns are usually, but not always, removed before sold.)
HOW TO STORE Store in an airtight plastic bin or ziplock bag or wrap in plastic wrap. In the crisper drawer of the refrigerator, succulents will keep for 1 week.
HOW TO REFRESH Use as soon as possible after purchase and preparation because most succulents really can't be refreshed once dehydrated.
COOKING METHODS Serve raw in salads or cook by boiling, broiling, roasting, sautéing, grilling, or poaching.
PAIRINGS Citrus, lime, tomatillos, tomatoes, chiles, tropical fruits, meats, poultry, firm-fleshed fish such as tuna.
P.S. I LOVE YOU
I grew up in southern California and we always had aloe growing in a pot. We mostly used the juice in the leaves to quell the pain from sunburns and small cuts or sores. My family spent a lot of time in the desert close to Palm Springs (aka PS), and if it was sunny, I was probably sunburned. Sometimes my mom would buy a large jar of aloe juice and keep it in the fridge. We never really cooked with it then, but today, I like to use it in cocktails. This one is a favorite because I love tequila, and it happens to be made from agave (as is mezcal). Combining tequila with aloe, which is in the same family, is always a good idea. The result is a clean, bright, drink with a little texture thanks to the heft of the aloe vera juice, which also boasts antioxidants is good for digestion.
SERVES 1
2 sprigs cilantro
2 ounces [60 ml] blanco tequila
1 ounce [30 ml] aloe vera juice (recipe follows)
¾ ounce [20 ml] fresh lime juice
½ ounce 15 ml] [simple syrup
Pinch of kosher salt
Ice
3 ounces [90 ml] celery soda
½ ounce [15 ml] grapefruit juice
Thin strips of young aloe, to garnish
Thinly sliced lime, for garnish
Combine the cilantro, tequila, aloe vera juice, lime juice, simple syrup, and salt in a shaker filled with ice. Shake well and strain into a highball glass filled with ice. Top with the celery soda |
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] |
While Taylor has now broken records in the pop genre, Little Big Town insists she hasn’t completely parted with her country roots.
“She’s a Nashville songwriter,” Little Big Town‘s Karen Fairchild told USA Today. “When you write a song like “Better Man” top to bottom on your own with your acoustic guitar, that’s Nashville. She’s a storyteller. She loves country music. Her last record was more poppy but who knows? Taylor can do anything she wants to. And she will forever be a Nashville girl.”Q:
How to extract text data in a table created in a docx document
I would like to extract text from docx document, I come up with a script extracting text from docx document but I noticed that some document have table and the script do not work on them, How can I improve the above script :
import glob
import os
import docx
with open('your_file.txt', 'w') as f:
for directory in glob.glob('fi*'):
for filename in glob.glob(os.path.join(directory, "*")):
if filename.endswith((".docx", ".doc")):
document = docx.Document(filename)
for paragraph in document.paragraphs:
if paragraph.text:
#docText.append(paragraph.text)
f.write("%s\n" % paragraph.text)
docx with table
A:
Try using python-docx module instead
pip install python-docx
import docx
doc = docx.Document("document.docx")
for table in doc.tables:
for row in table.rows:
for cell in row.cells:
print(cell.text)
Promoting Health and Behavioral Health Equity in California.
Behavioral health disparities are not usually considered part of the same system of health disparities. However, the California Department of Public Health focused its health equity strategies on reducing behavioral health disparities through its California Statewide Plan to Promote Health and Mental Health Equity. This statewide plan was developed through a community-wide stakeholder engagement and outreach process. In addition, the California Reducing Disparities Project is a prevention and early intervention effort to reduce mental health disparities in underserved populations. This strategic plan represents the voice of several racial/ethnic communities, such as African American, Asian and Pacific Islander, Latino, Native American, as well as lesbian, gay, bisexual, transgender, and queer and questioning communities in California, through 5 strategic planning workgroups. The workgroups were composed of a broad range of stakeholders, including community leaders, mental health care providers, consumer and family members, individuals with lived experience, and academia. This case example highlights the various efforts of California's Office of Health Equity in eliminating behavioral health disparities and promoting mental health equity, as well as discusses the unique statutory and regulatory role of the Office of Health Equity's deputy director.@import "~styles/variables";
thead {
font-size: 14px;
letter-spacing: 0.2px;
color: $chef-primary-dark;
}
th {
text-align: left;
padding: 0px;
}
tbody > .detail-row {
padding-top: 0px;
padding-bottom: 15px;
}
chef-table-new {
.controls {
text-align: right;
}
a {
cursor: pointer;
text-decoration: underline;
}
}
chef-loading-spinner {
display: block;
margin: 100px auto;
width: 100px;
z-index: 199;
}
Q:
Laravel 7.0 MySQL SQLSTATE[HY000]: General error: 1824 Failed to open the referenced table
System Info:
OS: Ubuntu 19.10
Laravel Version: 7.0
PHP Version: 7.3.11-0ubuntu0.19.10.4
MySQL Version: mysql Ver 8.0.19-0ubuntu0.19.10.3 for Linux on x86_64 ((Ubuntu))
I am building a small Laravel application and am having an issue with MySQL and relationships. When I try to run my migrations, this is the error I get:
SQLSTATE[HY000]: General error: 1824 Failed to open the referenced table 'customers_table' (SQL: alter table `customer_contacts` add constraint `customer_contacts_customer_id_foreign` foreign key (`customer_id`) references `customers_table` (`id`))
And these are the two migration files in question.
customer table and migration:
<?php
use Illuminate\Database\Migrations\Migration;
use Illuminate\Database\Schema\Blueprint;
use Illuminate\Support\Facades\Schema;
class CreateCustomersTable extends Migration
{
/**
* Run the migrations.
*
* @return void
*/
public function up()
{
Schema::create('customers', function (Blueprint $table) {
$table->id();
$table->string('company_name', 50);
$table->string('phone_number', 20)->nullable();
$table->string('fax_number', 20)->nullable();
$table->string('address_line_1', 75)->nullable();
$table->string('address_line_2', 75)->nullable();
$table->string('city', 75)->nullable();
$table->string('state', 30)->nullable();
$table->string('zip', 11)->nullable();
$table->string('industry', 100)->nullable();
$table->text('notes')->nullable();
$table->timestamps();
});
}
/**
* Reverse the migrations.
*
* @return void
*/
public function down()
{
Schema::dropIfExists('customers');
}
}
And the customer_contacts table and migration:
<?php
use Illuminate\Database\Migrations\Migration;
use Illuminate\Database\Schema\Blueprint;
use Illuminate\Support\Facades\Schema;
class CreateCustomerContactsTable extends Migration
{
/**
* Run the migrations.
*
* @return void
*/
public function up()
{
Schema::create('customer_contacts', function (Blueprint $table) {
$table->id();
$table->foreignId('customer_id')->constrained('customers_table');
$table->string('name', 50);
$table->string('title', 50);
$table->string('project', 50);
$table->string('email', 50);
$table->string('mobile_phone', 20);
$table->string('work_phone', 20);
$table->timestamps();
});
}
/**
* Reverse the migrations.
*
* @return void
*/
public function down()
{
Schema::dropIfExists('customer_contacts');
}
}
And this is the relevant section from my database.php file:
...
'mysql' => [
'driver' => 'mysql',
'url' => env('DATABASE_URL'),
'host' => env('DB_HOST', '127.0.0.1'),
'port' => env('DB_PORT', '3306'),
'database' => env('DB_DATABASE', 'forge'),
'username' => env('DB_USERNAME', 'forge'),
'password' => env('DB_PASSWORD', ''),
'unix_socket' => env('DB_SOCKET', ''),
'charset' => 'utf8mb4',
'collation' => 'utf8mb4_unicode_ci',
'prefix' => '',
'prefix_indexes' => true,
'strict' => true,
'engine' => 'InnoDB',
'options' => extension_loaded('pdo_mysql') ? array_filter([
PDO::MYSQL_ATTR_SSL_CA => env('MYSQL_ATTR_SSL_CA'),
]) : [],
],
...
I tried changing my database to SQLite to see if I get the same error and I do not, only MySQL creates this error.
A:
Use
$table->foreignId('customer_id')->constrained('customers')
Instead of
$table->foreignId('customer_id')->constrained('customers_table');
Cheers Dave – the short answer is I don’t I fire everything up, open up the aperture and then retire indoors to the study to drive everything from the warm. |
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] |
"Fuck you, too, David. I'm out of here." Sasha was sick of all of them. She'd seen where the bullets were buried and that was all she needed to know. She turned on her heel and started up the hill, breaking into a jog.
"Sasha!" Julian called after her. "Catch you later?"
"Forget it!" Sasha called back, charging up the hill.
## CHAPTER 14
■
## Julian Browne
Julian's mother entered the room with a tray holding a bowl of popcorn and root beer floats. She had gone to a lot of trouble, but all he could think about was Sasha. It was already past eight o'clock at night, and Sasha hadn't been home since they buried the gun and bullets. He'd been watching the house, and her room was completely dark. The only lights on were in Bonnie and Clyde's suite and the family room downstairs, which they kept on when Sasha wasn't home. Julian didn't know where she was, and it was driving him crazy.
"Movie night!" his mother said, setting down the tray. "How much fun is this?"
"Fun." Julian smiled, hoping it looked convincing. "Real butter and everything?"
"Nothing but the best for my baby!" His mother put a napkin in front of him, then a root beer float with a special long spoon. His parents used to entertain all the time, and his mother had shrimp forks, mother-of-pearl caviar spoons, and cake knives. She even had special ice cream dishes, gravy boats, soup tureens, and ramekins; Julian knew the names because she took the time to educate him. Now the only person she was entertaining was him.
"I just love that we get to spend this time together, truly quality time."
"Right." Julian glanced out the window, keeping an eye on Sasha's house. Their family room was cavernous with brown leather sectionals arranged opposite the fireplace and entertainment center, and on the left side of the room, they had huge Palladian windows. It gave Julian a great view of the street, and from this angle, Sasha's house. The light over her front door was on. He sensed she was punishing him for what happened with Allie.
"Have some root beer float. It's going to melt."
"Good point." Julian picked up the spoon and slurped some root beer float, which tasted absolutely delicious. "This is perfect, Mom. Thanks."
"I love that you still drink it with the spoon. You used to do that when you were little."
"This spoon seemed bigger then."
"I'm sure." His mother grinned broadly, so excited on these weeknights, when it was _her night_ as opposed to _his father's night_ , since Julian went to his dad's house on alternating Tuesdays and Thursdays, depending on if he had been there the weekend. His mother always tried to plan something special for them, which they had never done when his father lived at home. He secretly wondered if she felt she had to, in order to win him over in the battle of who he liked better, mommy versus daddy. Of course she won hands-down, but he could never convince her of that and he understood why. His father offered motorboats, blondes, and no adult supervision. Because his father wasn't an adult.
"Which movie do you want to watch first?" His mother held up the two VHS tapes, her pick, _You've Got Mail,_ and his pick, _The Big Lebowski_.
"We can watch yours first, Mom."
"No, we can do yours."
"Please, you love chick flicks." Julian glanced out the window, but the Barrow house was still dark and quiet. One of their neighbors was walking his malamute, but nobody else was on the street.
"No, we watched mine first last time, remember? I love a double feature!"
"What's a double feature?"
"Oh my, I'm dating myself. Oh well, somebody has to these days!" His mother laughed as she crossed the room, slid the tape into the VHS player, and picked up the remote, hitting a few buttons to get the tape running. She eyed _The Big Lebowski_ box. "What's this about again?"
"It's great, I love it."
"Wait, you saw it already?"
"Yeah, I told you at the store."
"I didn't hear you. Don't tell me my hearing's going now, too."
"I saw it with Dad." Julian didn't add that his father hadn't seen the movie with him, just dropped him off. "It doesn't matter. I want to see it again."
"I didn't want you to have to sit through something you saw already."
"But I love it. I want to."
"Okay." His mother returned her attention to the movie, which was starting. "So is that man the big Lebowski? He wears a bathrobe to the grocery store?"
"Yeah, he's a stoner."
His mother frowned. "You mean he smokes dope?"
"Weed."
"We called it dope, in my day."
"People call it weed now." Julian didn't explain that his father called it weed, even though he was from the same day. Nor did he tell her that his father smoked weed on the boat.
"But _you_ would never smoke dope, er, weed." His mother shot him a look.
"No, I wouldn't." Julian didn't say that he'd tried weed for the first time when his father gave him some on a trip to Cape May. Julian had liked smoking with his dad and the blonde _du jour_. His father let him have beer, too, but Julian took it easy because beer made him fart, which would not be cool.
"Don't even experiment with it, okay?" His mother sat down on the couch. "They tell you that in school, right?"
"Yeah, in D.A.R.E., since middle school." Julian didn't add that the weed-and-beer combination made him throw up over the side of the boat. His father had laughed, and the blonde hadn't known what to do, though his mom would have brought him a ginger ale.
His mother frowned at the TV screen. "Does this glorify drug use?"
"It's a comedy; he's funny." Julian was so preoccupied he couldn't think straight. Sasha still wasn't home. She dated seniors like Jake Myers, Malcolm Hobb-Jacobs, and Zachary Pearlstein, major competition. Julian knew their cars, so when one of them dropped her off, he would know who.
"Jeff Bridges used to be so handsome! He really let himself go for this role!"
"He drinks White Russians. That's his thing. He drinks them all the time. He calls them his 'beverage.'" Julian didn't remind his mother that she had drunk plenty in her entertaining days, and she fell silent, watching the movie with growing disapproval.
"There are a lot of f-words in this movie, honey." His mother shook her head, clucking. "Why would your father take you to a movie that's so inappropriate?"
"I asked."
"It's not on you, it's on him. What's it rated?"
"Don't worry about it, Mom." Julian rolled his eyes, restless. This was going to end up with his mother calling her lawyer, then her lawyer calling his father's lawyer, who would talk to his father, which sucked. The movie went on without Julian seeing it, thinking of Sasha.
"Oh no, who are those guys?"
"Bad guys."
"Why are they hurting him?"
"They have him mixed up with another Lebowski. He's Jeffrey Lebowski, the Dude. They think he's a millionaire."
"Wait, are they _peeing on the rug_?" His mother threw up her manicured hands. "Julian, how can you like this movie? It doesn't make any sense."
"Let's watch yours then, okay?" Julian couldn't enjoy it anyway. Where the hell was Sasha? Who was she with? Was she having sex with one of those seniors? Seniors got it all the time, didn't they? They expected it! It made Julian crazy because he had loved her for forever.
"You mean stop watching it? Are you sure you don't mind?" His mother pouted prettily, like the cheerleader she'd been, and Julian realized that beautiful women always got what they wanted. Sasha sure did.
"I saw it already. See, it turned out fine."
"You sure?"
"Please put on your chick flick, Mom."
"Don't call it a chick flick. It's a love story. Men can enjoy love stories, don't you think?"
"Yes," Julian said, ironically in the circumstances. Suddenly he noticed a car pulling up in front of Sasha's house. Zachary Pearlstein's red BMW 325.
"Here we go! Oh, I love Tom Hanks. Isn't he just the best? I think he's so cute |
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] | a catalog. When it came, no lie, my kids fought daily over who would get to read it on the bus, and how long each was allowed to have it, and whether or not the others were taking good care of it during their turns.
Even the neighbor boys were in awe of this treasure. It didn't take me long to realize what I needed to do.
I needed to call LEGO. After I explained that just one was not going to do it for us, I signed ALL THREE of my boys up to receive their very OWN catalog.
They have anxiously anticipated them from that moment onward.
Like I said, they "read" them on the bus. They read them in the car. They read them while we're waiting--just about anywhere. They read them in their bedrooms, and at the kitchen counter. They read them in the bathroom and even under blankets with a flashlight. Yes, boys, I know about that.
So order. It's FREE! The boys in your life will think you rock. And that doesn't happen nearly enough!
We've not tried this one, but LEGO also has a program called BrickMaster. It costs $39.99 and comes with six BrickMaster Edition LEGO magazines (one every two months), Six surprise LEGO toys (mailed out one every two months), two LEGO Shop at Home Coupons, and a free LEGOLAND California Admission ticket. If any of you have tried this, I'd love to hear your thoughts on it!
11 comments:
You also need to sign the boys up for the Lego and Bionicle MAGAZINES! My son thinks they are the greatest things ever produced, and they both are completely free - he has been getting them for a few years now! Have fun!!
Augh -- I tried to do it, and saw that it asked about age ranges. I didn't read and just assumed they were asking the age of my kids. Oops -- must have been asking my age, because now it won't let me ask for a catalog. D'oh!
We signed up for the magazine a few months ago and my son kept asking whether or not the magazine had come in the mail and if it didn't he thought I ought to call them and remind them or see what was happening - he was so eager to get it. And then - just b/c of the timing of our subscription we got 2 or 3 in a very short time - so he was happy.
All three of my kids loved LEGOS when they were younger. And LEGO land was the ultimate play place for them! Now that they're older, I'm just waiting for them to have kids so I can start stocking up on LEGOS again!
We love Lego mags at our house! In fact, I have to hide them so they don't discover them until AFTER homework is done. I've also been thinking about the Brickmaster thing. My guys have told me it would be "hard to share," so I'm looking at 2 - which means $80 - not that it doesn't seem worth it. I'm thinking Brickmaster may be birthday presents in 2009.
"Let's raise our children up in prayer. . . . . . as we raise them up to serve our God!"Here, you'll find food for thought, helpful tips, DIY tricks, and stories from everyday life, all posted with the hope of encouraging and strengthening families in every aspect of life.
Followers
Great Resources
Product ReviewsDo you have a family friendly product you think my readers would like? I give honest and informative reviews of family friendly products. Please feel free to drop me an email and we can discuss the possiblity of sharing your product with my readers! Be sure to include "review" in the subject line.5 tablespoons (1/3rd cup) bleach per gallon of water
OR
OR 4 teaspoons bleach per quart of water
Follow manufacturer’s instructions for application and proper ventilation. Check to ensure the product is not past its expiration date. Never mix household bleach with ammonia or any other cleanser. Unexpired household bleach will be effective against coronaviruses when properly diluted.Cannabis industry exploding with growth here, says top pot exec
The cannabis business is growing like a weed, even as pot stocks see wild swings. With Smoke Wallin, Vertical Companies, CNBC's Scott Wapner and the Fast Money traders, Pete Najarian, Tim Seymour, Karen Finerman and Guy Adami.Shifts of system performance and microbial community structure in a constructed wetland after exposing silver nanoparticles.
The increasing utilization of silver nanoparticles (Ag NPs) in industry and commerce inevitably raises its release into wastewater. In this work, effects of Ag NPs on system performance and microbial community along the way of a vertical flow constructed wetland (VFCW) were investigated, along with the removal and fate of Ag NPs within the system. Results showed that the performance of control wetland kept stable during the experimental period, and the top substrate layer (soil layer) of wetland could remove most of pollutants in the influent. The study also suggested that addition of Ag NPs did not significantly affect organic matters removal. However, adverse effects were observed on the nitrogen and phosphorus removal. Removal efficiencies of TN, NH4+-N and TP approximately obviously reduced by approximately 10.10%, 8.42% and 28.35% respectively in contrast to before dosing after exposing 100 μg/L Ag NPs for 94 d, while the no dosing wetland with the stable performance. It was found that Ag NPs accumulated in the upper soil layer more than in the lower soil layer, and Ag NPs could enter into the plant tissues. After continuous input of Ag NPs, removal efficiency of Ag NPs was measured as 95.72%, which showed that the CW could effectively remove Ag NPs from the wastewater. The high-throughput sequencing results revealed that Ag NPs caused the shifts in microbial community structures and changed the relative abundances of key functional bacteria, which finally resulted in a lower efficiency of biological nitrogen and phosphorus removal.John Vorster Square in central Johannesburg is a building as cold and formidable as the man it was named after: South Africa's prime minister from 1966 to 1978.
Created as a detention centre for mainly political prisoners, the forbidding grey-and-blue, 10-storey cement building, now known as the Johannesburg Central Police Station, was described in 1971 as the "last word in security" by the liberal South African newspaper, the Rand Daily Mail.
In his book, Timol: A Quest for Justice, Imtiaz Cajee, nephew of anti-apartheid activist Ahmed Timol, wrote of the "paranoia of its turnstiles clamping together like metal teeth".
To Cajee, whose uncle died at John Vorster Square, it was "the ultimate symbol of the bureaucratisation of fear and horror under apartheid".
Former Minister of Health and of Public Enterprises Barbara Hogan, who - as the first South African woman to be found guilty of high treason - was detained there, described it as an "iconic institution" that symbolised "the reign of the mad forces".
The ninth and 10th floors of the building were where the headquarters of the Security Branch was located. They could be accessed by two special lifts that ran straight from the basement to the headquarters.
The Security Branch offices contained special soundproof rooms. Direct-line telephones were connected to the Security Branch headquarters in the capital, Pretoria. The detainee cells were on the lower floors.
The Johannesburg Central Police Station, formerly known as John Vorster Square, was the site of the death of political activist and detainee Ahmed Timol [GULSHAN KHAN/AFP]
Detention without trial
John Vorster Square was one of the architectural symbols of apartheid. But the real pillars of apartheid were the draconian security legislation passed to segregate and intimidate.
One of the most chilling laws passed during Vorster's leadership was the Terrorism Act of 1967 which allowed the police to detain indefinitely and in solitary confinement anyone suspected of "terrorism" - defined as anyone who might "endanger the maintenance of law and order" - or having information about terrorism. No court could intervene, and no one had access to the detainees.
According to George Bizos, a celebrated human rights lawyer who represented many families of apartheid-era detainees, John Vorster's name became associated with detention without trial. "The name John Vorster inspired fears among detainees," said Bizos.
One of the most common methods of torture used in John Vorster Square was "standing torture", during which detainees were prevented from sleeping or sitting down for many hours on end.
At least 73 political activists are thought to have died in South African police detention between 1963 and 1990 - eight of them during or as a result of their detention at John Vorster Square.
In spite of the work of the Truth and Reconciliation Commission (TRC) between 1996 and 1999, most of these cases remained shrouded in secrecy.
That was until inquests into the deaths began to be reopened in 2017, in large part thanks to the tireless efforts of Imtiaz Cajee.
"Imtiaz has been waging a long campaign for truth and justice," said Howard Varney, lawyer for the Timol family.
The first inquest to be reopened was that of Ahmed Timol, the first activist who died at John Vorster Square.
Ahmed Timol
Born in 1941, Ahmed Timol, who was of Indian heritage |
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] | they
are moot, irrelevant, or without merit.
To reflect the foregoing,
Decision will be entered
under Rule 155.
Beta (20-28 Hz) and delta (0.3-3 Hz) EEGs oscillate reciprocally across NREM and REM sleep.
Across-night oscillations of beta (20-28 Hz) and delta (0.3-3 Hz) electroencephalograms (EEGs) were examined with spectral analysis in 10 normal young adult subjects (Ss). In each S, power densities of beta were found to oscillate reciprocally with delta power density across both nonrapid eye movement (NREM) and rapid eye movement (REM) sleep. Linear correlation coefficients between log power density of delta vs. beta were significant (p less than 0.0001) for each S. An incidental observation was that beta power within REM was reliably lower in epochs with more eye movement activity. The reciprocal relationship between beta and delta holds implications for sleep physiology and supplements our earlier finding that sigma (12-15 Hz) oscillates reciprocally with delta within NREM sleep. These descriptions of the continuously varying EEG across sleep provide information not available when EEG measures are tabulated by discrete NREM periods and REM periods.As the legislation matures and more directives are formulated, more issues will undoubtedly come to light. To the credit of the office of the Information Regulator, there is a commitment to adopt privacy best practices from around the world. This should provide a solid basis from which to move forward with efforts to protect personal information in South Africa.
The practical implications of PoPIA certainly needs considering. Our PoPIA Team has put together answers to a few of the questions being asked on PoPIA forums.
How will POPIA protect my personal information collected by the security guards when visiting a complex/residential building?
All responsible parties who collect PI for security reasons must ensure the prevention of loss, damage or unlawful processing of PI given for this purpose. In other words, if the PI you have given to gain access to a building is lost, processed unlawfully by another party or damaged in any way that would constitute a breach and as the data subject you would have recourse to the regulator.
Does government get held to the same standard as private sector in the event of a breach?
Yes, indeed. POPIA applies to all public institutions except for PI processed during a criminal investigation or investigation of any activities related to the financing of terrorism or money laundering. The exception also applies in cases considered sensitive for national security reasons as well as PI processed by the judiciary and the Cabinet. (See section 6 of POPIA)
Would a General Practitioner (GP) need to disclose to all patients that they had a data breach, even if only one patient has been compromised?
The GP would only have to disclose to the affected patients, unless the GP is ordered to publicise the breach by the information regulator.
Who will be responsible if government departments share citizens’ personal information with companies e.g. sharing with SANRAL?
I assume this question relates to SANRAL and e-tolling in South Africa. The lawfulness of e-tolling is being challenged by OUTA and is far more complex than the processing of PI. Exactly how sharing of PI across government agencies and different levels of government (i.e. municipal, provincial and national) will apply, I would suggest, will only be known once the Act is in force, regulation has been published and case law exists. The Act does specifically allow for the sharing of PI from private organisations with the South African Revenue Service.
How are employees of companies affected by this law if they have access to client information on their mobile devices?
Any personal information belonging to clients and stored on mobile devices must meet the security safeguards of prevention of loss, damage or unlawful processing. In practical terms, encryption of all mobile devices is the reasonable control to meet the minimum standards.
How would an individual, like a family GP, be ‘punished’ for a data breach?
Contravention of POPIA in South Africa will be a criminal offence. Any GP contravening the Act will face administrative penalties (fines) and/ or a prison sentence not exceeding 10 years. See chapter 11, sections 107 and 109 of POPIA.
What are the POPIA directives for IT and processing environments?
In terms of POPIA and the definition of processing, which includes the collection, storage, retrieval and dissemination of PI for lawful processing, any IT service provider would be deemed to be operators.
The responsible party (that is, for example, GP practices) must ensure that all operators, including IT service providers, meet the minimum-security safeguards as contained in condition 7 of POPIA.
Like this:
Related
Pétanque NXT
We partner with companies who want to understand and integrate the new 4IR–driven possibilities to reduce cost, improve how they serve their customers and ensure their leadership position in the new business landscape.Utility Planet is the official blog for the column of the same name in The Spectrum Monitor. It replaces Utility World in the discontinued Monitoring Times magazine. Utilities are all VLF/LF/MF/HF (and sometimes low-band VHF) radio communications except broadcasting, CB, and non-emergency amateur. If you understood the last sentence, you know enough to read this blog.
Friday, July 28, 2017
More broadcasters are making use of the 9400 kHz frequency from
Space Line in Bulgaria. If you have ever considered producing your own radio program,
either digital text or traditional voice, contact Space Line via spaceline.bg
(I think Saturday 1630-1700 UTC is available!), or Radio Miami International via
wrmi.net.
(I do not work for or derive income from either transmission company.)
This weekend, most of Shortwave Radiogram is in our usual MFSK32
mode, with five images. If reception is difficult, there is also one brief item
from Radio Prague in Olivia 64-2000.
Here is the lineup for Shortwave Radiogram, program 6,
29-30 July 2017, all in MFSK32 except where noted:
The Mighty
KBC transmits to Europe
Saturdays at 1500-1600 UTC on 9400 kHz (via Bulgaria), with the minute of MFSK at
about 1530 UTC (if you are outside of Europe, listen via websdr.ewi.utwente.nl:8901/ ).And to North America Sundays at 0000-0200 UTC (Saturday 8-10 pm EDT) on 9925
kHz, via Germany. The minute of MFSK is at about 0130 UTC. Reports to Eric: [email protected] . See also http://www.kbcradio.eu/ and https://www.facebook.com/TheMightyKbc/.
Italian Broadcasting
Corporation (IBC)For the complete IBC transmission schedule visithttp://ibcradio.webs.com/Five minutes of MFSK32 is at the end of the 30-minute English-language “Shortwave
Panorama,” per the schedule below:
WEDNESDAY18.55 UTC6070 KHZ TO EUROPE
19.55 UTC1584 KHZ TO EUROPE
THURSDAY02.55 UTC1584 KHZ TO EUROPE
FRIDAY01.25 UTC9955 KHZ TO CENTRAL/SOUTH AMERICA
SATURDAY01.55 UTC 11580 KHZ TO NORTH AMERICA
20.25 UTC1584 KHZ TO SOUTH EUROPE
SUNDAY00.55 UTC7730 KHZ TO NORTH AMERICA
10.55 UTC6070 KHZ TO EUROPE
Thanks for your reports.I will begin sending replies and QSLs for SWRG program 4 this weekend.And I hope eventually to catch up!
I was amazed how well the MFSK64 (240 wpm) performed last
week, even under some marginal conditions. You can see videos of reception and
decoding via this link: https://twitter.com/SWRadiogram/status/885863588677791746
. It would be tempting to use MFSK64 as our “default” mode, except that there would
be enough instances of difficult reception that the number of errors would be
unacceptable.
Did anyone experience reception bad enough that only the
MFSK16 provided a perfect decode?
This weekend, let’s hope for bad reception – well, at least
somewhere – because we will include some Olivia 64-2000 in show. This is a slow
mode, only about 25 wpm. And it makes use of the entire 2000 Hz available to us,
so you probably don’t want to use an extremely narrow filter. Also, for best
results with Olivia 64-2000, turn the squelch (SQL at the bottom right of
Fldigi) off.
Here is the lineup
for Shortwave Radiogram, program 4, 15-16 July 2017, all in MFSK32 except
where noted:
The Mighty KBC
transmits
to Europe Saturdays at 1500-1600 UTC on 9400 kHz (via Bulgaria), with the
minute of MFSK at about 1530 UTC (if you are outside of Europe, listen via websdr.ewi.utwente.nl:8901/ ). And to North
America Sundays at 0000-0200 UTC ( |
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] | education and orientation programs. This should be considered carefully when planning the contents and educational methods for the programs.
There are approximately 30 intensive care units (ICUs) in Finland in which over 28,000 patients are cared for annually \[[@B1]\]. It is estimated that by the year 2030 the need for intensive and critical care will grow by 25%, for example, due to the fact that the Finnish population is getting older \[[@B2]\]. Multifactorial reasons increase the need of critical care beds in Finland and also in other countries in Europe.
Intensive care unit nurses (ICU nurses) are the largest professional group working in the ICUs. Severely ill patients and families benefit from the attention of highly trained and skilled personnel \[[@B3], [@B4]\]. ICU nurses contribute to patient safety, such as improved patient outcomes, reduced morbidity and mortality, and decreased complications, errors, and overall costs \[[@B5]--[@B10]\]. Competent ICU nurses have a significant impact on ICU patient\'s physiological and psychological outcomes, for example, evidence based nursing interventions and ethical activity.
Critical care nursing is an own nursing speciality \[[@B11]\] whereas technology is integrated with psychosocial challenges and ethical conflicts associated with critical illness \[[@B12]\]. Generally, critical care nursing education is a special postqualification education \[[@B13]\] and is described in the European Qualifications Framework for Lifelong Learning as level 6 (of eight) \[[@B14], [@B15]\]. Currently no postqualification education in intensive and critical care nursing leading to a degree exists in Finland.
We know that there is a worldwide need for competent nurses \[[@B16]\]. In nursing practice, nurses get to demonstrate on a regular basis clinical competence as well as a sound theoretical knowledge base according to nationally recognized frameworks \[[@B4], [@B17], [@B18]\]. There is a need for valid specific instruments (e.g., for intensive and critical care nursing) for competence evaluation purposes. Competence evaluation can be performed in various ways, for example, using self-assessment, knowledge tests, peer evaluation (colleague), observation (mentor, supervisor), OSCE (objective structured clinical examination), or portfolios. The best way to perform competence evaluation is to combine different evaluation methods. Self-assessment is an essential ability that can be learned and developed during education and nursing career.
Intensive and Critical Care Nursing Competence Scale research is scarce. Only three scales (Basic Knowledge Assessment Tool \[BKAT\], Intensive Care Hundred Item Test \[I-HIT\], and multilevelled critical care competency statements) of competence in intensive and critical care nursing are reported in nursing literature \[[@B19]\]. Of these scales, two are knowledge tests (BKAT + I-HIT) while the third one is based on nurses\' self-assessment; however, we are well aware that it has not been properly tested for reliability and validity and is still in its early phases. The need for a basic competence self-assessment scale in intensive and critical care nursing is therefore also evident, for example, for undergraduate education for beginning registered nurses practice standards. The systematic literature review conducted for this study in PubMed and search from critical care nursing organizations over the last ten years found 21 studies or documents of competence in intensive and critical care nursing (see the appendix).
As a summary of the literature, competence concept is very multidimensional (e.g., focusing on clinical practice \[nursing process\], ethics, collaboration, leadership, education, and development work) and strongly related to, for example, age, work experience, and frequency of using specific competencies. Competence is studied worldwide (10 documents from Europe, 7 documents from Australia and New Zealand, and 4 documents from USA, Canada, and Brazil); thus, there is lacking systematic competence evaluation research. Evaluation is often performed by self-assessment \[[@B20]--[@B22]\] or knowledge test \[[@B23]\]. ICU nurses\' self-assessed competence was evaluated as ranging from moderate to excellent: from moderate to good (sample consisting of newly registered ICU nurses) \[[@B22]\], good (sample consisting of ICU nurses with varying work experience) \[[@B20]\], and from good to excellent (sample consisting of ICU nurses with varying work experience) \[[@B21]\]. European ICU nurses\' overall knowledge score was 66% of 100 points (min 22, max 91, and SD 12); the main factor that contributed to variance in scores is length of nurses\' intensive care experience. The knowledge category with the lowest score was respiration and ventilation \[[@B23]\].
The purpose of this empirical study was to describe and evaluate the self-assessed basic competence of intensive care unit nurses and related factors using a scale, Intensive and Critical Care Nursing Competence Scale version 1 (ICCN-CS-1) \[[@B11]\]. The related factors were divided into the following areas: (i) age and gender, (ii) education, (iii) work experience, (iv) information retrieval, (v) knowledge test, and (vi) others. The hypothesis was that the basic competence can be explained with these. This empirical study is part of a larger project where the scale was developed \[[@B19]\]. This study was conducted to facilitate establishment of the psychometric properties (reliability and construct validity) of the scale being used \[[@B24]\]. The project from which this study is a part aimed to define competence in intensive and critical care nursing (ICCN), to develop a basic self-assessment based measurement scale for competence evaluation in ICCN, and to describe graduating nursing students\' basic competence in ICCN by seeking reference basis from ICU nurses.
ICU nurse is a registered nurse who practises in an ICU and whose nurse education is Bachelor of Health Care, specialist nurse, or nurse. In this ICU nurses basic competence study was used also the experience base of the ICU nurses in data analysis which were not analysed in graduating nursing students\' basic competence study. The students had no experience base enough in ICCN and therefore in data analysis only three bases of four were analysed knowledge, skill, and attitude and value bases. A novel issue in this study is that it highlights the multidimensionality of the concept of competence. Four bases of competence in intensive and critical care nursing were analysed in ICU nurses\' data: knowledge base, skill base, attitude and value base, and experience base \[[@B19]\].
ICCN-CS-1 measures basic competence and it refers to preliminary competence to practice in an ICU. It is comparable to step 1 competencies of the National Competency Framework for Adult Critical Care Nurses \[[@B25]\] and Critical Care Nurse Education Practice Standards \[[@B26]\]. ICCN-CS-1 is useful in planning supervision in preregistration nursing students\' clinical practice and during orientation programmes, for example, to identify learning gaps, define learning goals, and discuss competence in a comprehensive manner. The content of the scale is in line with postgraduate education standards and the competence standards of critical care nurses, also at specialist level. The scale measures the basic competence in intensive and critical care nursing and can be used as a starting point for the transition process from preregistration education to postgraduation education. The scale was developed for intensive and critical care education purposes, for example, for preregistration education and in orientation programmes. The results of this study can be useful in nursing education, especially in basic education and when planning continuous education. In clinical practice the results can also be helpful in professional performance appraisals in ICUs.
2. Materials and Methods {#sec2}
========================
2.1. Aim {#sec2.1}
--------
The aim of the study was to describe and evaluate the self-assessed basic competence of intensive care unit nurses and related factors. The results of this study will help educators, clinicians, and researchers to develop basic nursing education and orientation in the ICUs.
2.2. Research Questions {#sec2.2}
-----------------------
The research questions for this study were as follows:What is the level of intensive care unit nurses\' self-assessed basic competence?What are factors related to the basic competence?
2.3. Design {#sec2.3}
-----------
A cross-sectional survey design was employed using questionnaires among Finnish ICU nurses in university hospitals.
2.4. Sample/Participants {#sec2.4}
------------------------
Total sampling was used for ICU nurses in five Finnish university hospitals (*n* = 431 participants, response rate 54%). In one of the five university hospitals, a convenience sample of ICU nurses (*n* = 82 participants, response rate 37%) also completed a biological and physiological knowledge test. In 2008, a pilot study had been conducted in one university hospital; this organization was therefore not included in this data gathering in 2010. The final number of hospitals taking part in this study was thus four.
2.5. Data Collection {#sec2.5}
--------------------
Data were collected using a questionnaire with the support of contact persons in the ICUs. The instruments used in this study were the Intensive and Critical Care Nursing Competence Scale (ICCN-CS-1) \[[@B24]\] and a knowledge test, the Basic Knowledge Assessment Tool version 7 (=BKAT-7) \[[@B27]\], which was used as the background factor in the convenience sample. Background factors (12) integral to the ICCN-CS-1 were asked and they formed the first page of the questionnaire.
ICCN-CS-1 is a self-assessment tool consisting of 144 items (six sum variables). The scale measures basic competence in intensive and critical care nursing. Theoretically, basic competence is divided into clinical competence and professional competence. Clinical competence consists of three subdomains: principles of nursing care, clinical guidelines, and nursing interventions. Professional competence consists of four subdomains: ethical activity and familiarity with health care laws, decision-making, development work, and collaboration. |
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] | or other factors.
So now let’s look at the average movement under different wind conditions, compared to those inside the dome. Pitch f/x movement is always measured in comparison to a spinless pitch, so the average for a knuckleball averages around 0 for both x (horizontal movement in inches, with positive values representing movement towards a left-handed batter) and y (vertical movement), since the random movement in all directions that the knuckleball takes on from there cancels out.
(Keep in mind that this is simply a measure of where the pitches tend to end up crossing the plate compared to where they would have if nothing was happening at all. This doesn’t have anything to say about when or how they flutter on the way to the plate.)
Effect of wind on Knuckleball movement and results Wind PFX PFZ In Zone % Miss % None (Dome) 1.18 1.61 0.49 0.39 Right to Left 0.05 0.03 0.50 0.30 Left to Right -0.26 0.57 0.49 0.33 In 0.17 1.27 0.48 0.37 Out 0.20
0.32
0.50
0.33
So while a crosswind seems to have no particular (at least consistent) effect, on average Dickey’s knuckleball is more likely to have almost two inches more of up-and-away movement with the dome closed than in other wind conditions (the results are even more compelling if we only look at Dickey’s 76+ mph knuckleballs again: [pfx: -0.24 pfz: 1.35 with the dome open vs. pfx: 0.80 pfz: 2.15 with it closed]. As I showed in a previous article, that direction of movement is by far the most deadly: “Hitters swing through them almost twice as often as ones that sink down and in, and get fewer hits when they do make contact.”
There may be other reasons, but that makes sense considering that it’s a type of movement that is not seen in any other pitch. Sometimes Dickey’s knuckleball ends up having similar action to a changeup, or a slider, or even a rising fastball. But no other pitch in the world moves in that direction (Mariano Rivera’s cutter came the closest)
Theory 3: Higher humidity (with the dome closed) is good for the knuckleball.
Dickey has mentioned humidity as a factor several times, and In an interview with Michael Morrissey, Dickey gives his theory on how it helps the knuckle:
As expected, Dickey noted that domes and places with high humidity are good environments for his knuckleball. Domes are good because of the lack of wind. High humidity is good because “the seams grip the air better.”
But then in another interview, Dickey seems to suggest that it has an adverse effect (although he could be referring to overly humid conditions making it hard for him to get the proper grip, as most pitchers see their K rates drop at very high temperatures, most likely due to sweat):
Yes, a controlled climate is (desirable) and a dome offers you that,” Dickey said. “But if it’s been open all day and then it’s closed at game time, all that humidity (gets) stuck there and that’s not good (for a knuckleball).”
Anyway, humid air is actually less dense than normal air (seems backwards but is true), so I don’t buy the idea that it would grip the seams more. And if anything, less drag should make the knuckleball have less movement (imagine pushing a beachball through water compared to air). But another thing that would cause less resistance on the ball is having the wind at Dickey’s back — which is the other number that pops out from the above movement table as causing Dickey’s knuckleball to rise. (Wind “in” on the above table, which is a combination of in from right, left, and centre field — if we isolate down to wind coming straight in from CF, pfz rises even higher to 2.16).
This supports the idea that higher humidity inside the dome makes Dickey’s knuckleball rise and become harder to hit, in much the same way that wind at his back does — but there’s something else with the dome closed that gives it sideways movement as well, away from right-handed batters. Or that’s my theory, anyway — for a much more rigorous look at the physics behind what makes the knuckleball do its thing, check out Alan Nathan’s site.
Verdict: Highly probable, but best left to real physicists.
In conclusion:
While it might have some kind of subtle effect, Dickey’s knuckleball is not more ‘accurate’ in any meaningful way with the roof closed.
Dickey’s knuckleball gets far more swings and misses when it rises/floats, especially up and away from right-handed batters.
He can throw it harder to make that happen but also gets more lift if he has the wind at his back, and more lift + movement away from right-handed batters with the roof closed.
The effect is much more pronounced on Dickey’s upper-70’s knuckleball than his lower-70’s offering, or his 65mph floater.
The results are significant enough that if Dickey was starting for the Jays in a critical game there is a strong argument to be made in favour of closing the dome. (Or maybe a humidifier promotion? Hand fans for everyone in centre field? Starting the “hurricane” instead of the “wave”? The possibilities are endless…)Hazel Ying Lee, who was born and educated in Oregon, was the first Chinese American woman to fly for the U.S. military, one of two Chinese Americans in the Women Airforce Service Pilots (WASPs)—the other was Margaret “Maggie” Gee from California—and one of thirty-eight WASPs who died in service. Known for her skill and courage, her peers considered her to be an excellent pilot.
Lee was born in Portland on August 24, 1912. Her parents, Yuet Lee and Ssiu Lan Lee, were Chinese immigrants who met and married in the United States, and then raised eight children in Portland at a time when anti-Chinese sentiment was prevalent. Hazel Ying Lee graduated from Commerce High School (now Cleveland High School).
Hazel Ying Lee was drawn to flying while still a teenager. She took a job as an elevator operator at Liebes Department Store in downtown Portland and saved money for private flying lessons. She later enrolled in the flying program sponsored by the Portland Chinese Benevolent Society and was flying by the time she was nineteen.
In 1932, Japanese military forces invaded and occupied Manchuria, China. The League of Nations demanded their withdrawal, but Japan refused, and by 1933 occupied the northern province of Jehol. Lee, like many Chinese Americans, traveled to China in hopes of joining the Chinese Air Force to oppose the Japanese invasion, but they did not accept women pilots. She worked a military desk job for a time and flew on occasion for a commercial outfit out of Nanjing before returning to the United States in 1938. In the Fall of 1942, she heard about and applied for the Women’s Flying Training Detachment (WFTD)—which became the Women’s Airforce Service Pilots (WASP) in 1943. She was accepted into the program, and during a six-month training regimen in Texas learned to fly a variety of military planes.
Lee graduated from the program in 1943. Shortly thereafter, the Women's Air Ferrying Service (WAFS) merged with the WFTD and was renamed WASPs. Lee was stationed at the Air Transport Command’s 3rd Ferrying Squadron at Romulus Army Air Base in Michigan, where she flew ferrying and administrative flights in Stearman Pt-17s, North American T-6 Texans, and the Boeing C-47, which could transport up to 6,000 pounds of cargo. In 1944, Lee attended Pursuit School in Brownsville, Texas, becoming one of a select group of women qualified to fly high-powered, single-engine, fighter aircraft, including the P-51 Mustang.
Known for her humor and fearlessness, Lee had only two forced landings in her career, one of which was in a Kansas farmer’s field. The farmer mistook her for Japanese and chased her around her plane with a pitchfork until she was able to convince him otherwise.
Hazel Ying Lee died on November 25, 1944, as a result of injuries sustained in a collision on a runway in Great Falls, Montana. Three days after hearing of her death, her family received a telegram informing them that her brother Victor had been killed in combat in France. The two are buried alongside each other at Riverview Cemetery in Portland.
Lee’s service was typical of the over one thousand women who joined the WASPs. On average, they were paid less than men, had to pay for their own room and board and even their own uniforms. They did not receive military benefits; and for those thirty-eight who died in service, the U.S. Air Force did not pay for funeral expenses. In 1977, President Jimmy Carter gave WASPs veteran status. President Barack Obama awarded the WASPs the Congressional Gold Medal in 2010.
Map It |
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] | so far.
<TJ-> Bercik: more details please ... kernel version, what you've tried, etc.
<Bercik> 3.13.0-19-generic, well.. I managed to mount bcache, make filesystem on it.. but when saving/reading from filesystem I don't see expected speeds.
<TJ-> Bercik: Was this a fresh new install with new block devices, or conversion of existing file-system(s)
<Bercik> It was a fresh install in VM, just to try out how bcache works.
<Bercik> I added 2 disk after I finished installing OS.
<TJ-> Bercik: If it's in a VM then performance would be dictated by the VM to some extent
<interweb> hello
<interweb> How do I can gpg a folder ?
<oldchinaphone> ++
<Bercik> TJ-, sure, but I can cleary tell that it's not working properly. HDD gets 40MB/s SSD around 220MB/s
<Bercik> even in benchmerks inside VM.
<licnep> trying to install 14.04, I already freed some 170GB on my HD. What would the install side by side with windows button do? Should I just click that or partition manually?
<kupo_> doesnt it ask you how much you want to use?like 8 gigs or whatever
<licnep> forget it i think i'll do it manually just to be sure. What about just a single ext4 / partition and a swap partition? (how much swap do i need for hibernation if i have 4 gigs of ram?
<licnep> kupo_: i already reduced the win partition by 170GB so all that space is empty and i will use it all for ubuntu
<kupo_> swap.i think 500 Mb or 750
<kupo_> i did too much on mine on accident and did like 3 gigs. but oh well
<licnep> if i recall correctly you needed swap to be at least as much as the ram for hibernation to work. But maybe that changed, i'm not sure
<kupo_> 500 or under is enough easily
<kupo_> you may be right
<kupo_> which is why mine is 3.50
<kupo_> i have hibernation issues . and since i use SSD i just shutdown now
<licnep> makes sense
<licnep> yea i never managed to get hibernation to work on my old laptop
<licnep> hopefully it will work on this one, but i know there are still a lot of problems about hibernation on linux
<kupo_> yeah. it worked perfectly for me before. but since i reinstalled Os. i have to do it via terminal. then it works fine
<TJ-> Bercik: Does "lsblk" show the bcache devices correctly configured?
<Bercik> give me a moment plz. I clread configuration and starting over..
<levo> any idea about how to convert a text searchable pdf file to a pdf image file? (formulas in the former aren't readable in e-reader)
<ningu> I'm getting some weird locale errors on a new server. I've installed language-pack-en-base, /etc/default/locale is set to en_US.UTF-8, and my env vars are set properly I believe. however I get errors like
<ningu> perl: warning: Setting locale failed.
<ningu> to make it stranger these errors occur for one user on the server but not another.
<ningu> any idea what's going on or how to debug it?
<drfoo_> greetings , doing a dist-upgrade ran into a snag
<drfoo_> Processing triggers for man-db ...
<Bercik> TJ-, sorry I just got a call and have to go. Are u available here most of the time? I'd like to continue with you if possible.
<drfoo_> ...usr/lib/man-db/manconv -f UTF-8:ISO-8859-1 -t UTF-8//IGNORE -q: Segmentation fault (core dumped)
<drfoo_> process is hung
<drfoo_> whats the best way to get out of this?
<drfoo_> kill process and reboot
<Scotty__> Hello, Yesterday I updated my Compat drivers on kernel 3.8 After that My screen resolution is all messed up. Xrandr shows that the current resolution (incorrect one) is the only resolution this supports. I tried to add my normal resolution on xrandr but got nothing. I tried install fglrx drivers, but that didnt help either. Does anyone have any suggestions?
<trism> ningu: try a: sudo locale-gen en_US.UTF-8;
<Scotty__> It should be noted, that previous kernel versions without this driver and patch work fine.
<ningu> trism: already did that :(
<trism> ningu: what is the output you are getting from running: locale;
<wieczorek1990> Handwritten music recognition survey. Still need some more replies. Please aid me: https://docs.google.com/forms/d/1wKc1yrfM4pwytpPDU91s5U14KxemtRUFtG7YOtgK7LQ/viewform
<ningu> trism: it generates a bunch of locales including en_US.UTF-8
<ningu> trism: sorry, I ran locale-gen with no args
<ningu> and the output was for that
<blind> Is there a way to do an apt-get install and specify certificate and private key? I know I can put it in apt.conf.d/45rulesname but that's not working so i'd like to try it manually.
<kane77> hi, what may be the reason that I cannot kill process?
<TJ-> blind: See "man apt-get" and "--option"
<kane77> I ran a game via Steam, but it was unresponsive so I used xkill to kill the window, but now I have a process that I'm not able to kill with kill -9
<ningu> trism: when I run "locale" I get: locale: Cannot set LC_CTYPE to default locale: No such file or directory
<ningu> what is the default locale?
<ningu> oh, wait. I think I see what's going on.
<semak> Hello
<Scotty__> It should be noted, that previous kernel versions without this driver and patch work fine. It should be noted that previous kernel verisons w/out the driver or patch work fine. Any suggestions?
<blind> TJ-: have you done apt-get -o for ssl information before? maybe my syntax is wrong?: '' apt-get update -o "Acquire::https::example.com={Verify-Peer \"true\"; Verify-Host \"true\"; CaInfo \"/etc/apt/ssl/CA.crt\"; SslCert \"/etc/apt/ssl/user.crt\"; SslKey \"/etc/apt/ssl/user.key\";};" ''
<TJ-> blind: ouch!!!
<limac> hi I'm getting this error after installing bumblebee with nvidia-331 in ubuntu 13.10: ... the class has no package named 'primus-libs-ia32' ...
<limac> anyone know what to do?
<TJ-> blind: For that I'd use "--config-file"
<blind> do you know, though, is that syntax correct? It's not working in a case where the conf file WAS working.
<blind> hm using -c did work. so syntax must be incorrect..
<blind> everybody on google is only doing this for proxy info :|
<TJ-> blind: enable the Debug::* options
<HelloWorld321> I like Empathy, but I don't notice it's notifications if I'm afk. I'm really only worried about my Momma, who's listed as my only "Favorite" contact. But its very normal for me to shut down my computer at the end of the day and see tray messages like "Are you there? Are you there?", and I'd like my Momma to think I'm not ignoring her. :(
<HelloWorld321> So the question is: should I change IMs, or is there a way to get Empathy to do more to grab my attention?
<cjae> Does ubuntu still use hdparm?
<cjae> In /etc/hdparm.conf there is literally no settings that are not uncommented
<g1_> My friend typed some "umask 000" command and lost root access. Cannot login to his own account. Recovery mode is also not showing on ubuntu. Any methods to get back root access via guest account or try ubuntu?
<majorhat> g1_: hey
<majorhat> Hey
<blind> TJ-: i got it. i had to do -o Acquire::https::example.com::Verify-Peer="true" -o Acquire:: |
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187,
187,
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605
] | ._tprefix(paths, term, true);
if (file) return file;
// Not found.
throw new Error('Terminfo directory not found.');
};
Tput._tprefix =
Tput.prototype._tprefix = function(prefix, term, soft) {
if (!prefix) return;
var file
, dir
, i
, sdiff
, sfile
, list;
if (Array.isArray(prefix)) {
for (i = 0; i < prefix.length; i++) {
file = this._tprefix(prefix[i], term, soft);
if (file) return file;
}
return;
}
var find = function(word) {
var file, ch;
file = path.resolve(prefix, word[0]);
try {
fs.statSync(file);
return file;
} catch (e) {
;
}
ch = word[0].charCodeAt(0).toString(16);
if (ch.length < 2) ch = '0' + ch;
file = path.resolve(prefix, ch);
try {
fs.statSync(file);
return file;
} catch (e) {
;
}
};
if (!term) {
// Make sure the directory's sub-directories
// are all one-letter, or hex digits.
// return find('x') ? prefix : null;
try {
dir = fs.readdirSync(prefix).filter(function(file) {
return file.length !== 1 && !/^[0-9a-fA-F]{2}$/.test(file);
});
if (!dir.length) {
return prefix;
}
} catch (e) {
;
}
return;
}
term = path.basename(term);
dir = find(term);
if (!dir) return;
if (soft) {
try {
list = fs.readdirSync(dir);
} catch (e) {
return;
}
list.forEach(function(file) {
if (file.indexOf(term) === 0) {
var diff = file.length - term.length;
if (!sfile || diff < sdiff) {
sdiff = diff;
sfile = file;
}
}
});
return sfile && (soft || sdiff === 0)
? path.resolve(dir, sfile)
: null;
}
file = path.resolve(dir, term);
try {
fs.statSync(file);
return file;
} catch (e) {
;
}
};
/**
* Terminfo Parser
* All shorts are little-endian
*/
Tput.prototype.parseTerminfo = function(data, file) {
var info = {}
, extended
, l = data.length
, i = 0
, v
, o;
var h = info.header = {
dataSize: data.length,
headerSize: 12,
magicNumber: (data[1] << 8) | data[0],
namesSize: (data[3] << 8) | data[2],
boolCount: (data[5] << 8) | data[4],
numCount: (data[7] << 8) | data[6],
strCount: (data[9] << 8) | data[8],
strTableSize: (data[11] << 8) | data[10]
};
h.total = h.headerSize
+ h.namesSize
+ h.boolCount
+ h.numCount * 2
+ h.strCount * 2
+ h.strTableSize;
i += h.headerSize;
// Names Section
var names = data.toString('ascii', i, i + h.namesSize - 1)
, parts = names.split('|')
, name = parts[0]
, desc = parts.pop();
info.name = name;
info.names = parts;
info.desc = desc;
info.dir = path.resolve(file, '..', '..');
info.file = file;
i += h.namesSize - 1;
// Names is nul-terminated.
assert.equal(data[i], 0);
i++;
// Booleans Section
// One byte for each flag
// Same order as <term.h>
info.bools = {};
l = i + h.boolCount;
o = 0;
for (; i < l; i++) {
v = Tput.bools[o++];
info.bools[v] = data[i] === 1;
}
// Null byte in between to make sure numbers begin on an even byte.
if (i % 2) {
assert.equal(data[i], 0);
i++;
}
// Numbers Section
info.numbers = {};
l = i + h.numCount * 2;
o = 0;
for (; i < l; i += 2) {
v = Tput.numbers[o++];
if (data[i + 1] === 0xff && data[i] === 0xff) {
info.numbers[v] = -1;
} else {
info.numbers[v] = (data[i + 1] << 8) | data[i];
}
}
// Strings Section
info.strings = {};
l = i + h.strCount * 2;
o = 0;
for (; i < l; i += 2) {
v = Tput.strings[o++];
if (data[i + 1] === 0xff && data[i] === 0xff) {
info.strings[v] = -1;
} else {
info.strings[v] = (data[i + 1] << 8) | data[i];
}
}
// String Table
Object.keys(info.strings).forEach(function(key) {
if (info.strings[key] === -1) {
delete info.strings[key];
return;
}
// Workaround: fix an odd bug in the screen-256color terminfo where it tries
// to set -1, but it appears to have {0xfe, 0xff} instead of {0xff, 0xff}.
// TODO: Possibly handle errors gracefully below, as well as in the
// extended info. Also possibly do: `if (info.strings[key] >= data.length)`.
if (info.strings[key] === 65534) {
delete info.strings[key];
return;
}
var s = i + info.strings[key]
, j = s;
while (data[j]) j++;
assert(j < data.length);
info.strings[key] = data.toString('ascii', s, j);
});
// Extended Header
if (this.extended !== false) {
i--;
i += h.strTableSize;
if (i % 2) {
assert.equal(data[i], 0);
i++;
}
l = data.length;
if (i < l - 1) {
try {
extended = this.parseExtended(data.slice(i));
} catch (e) {
if (this.debug) {
throw e;
}
return info;
}
info.header.extended = extended.header;
['bools', 'numbers', 'strings'].forEach(function(key) {
merge(info[key], extended[key]);
});
}
}
return info;
};
/**
* Extended Parsing
*/
// Some data to help understand:
// For xterm, non-extended header:
// { dataSize: 3270,
// headerSize: 12,
// magicNumber: 282,
// namesSize: 48,
// boolCount: 38,
// numCount: 15,
// strCount: 413,
// strTableSize: 1388,
// total: 2342 }
// For xterm, header:
// Offset: 2342
// { header:
// { dataSize: 928,
// headerSize: 10,
// |
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] | various public figures they meet. I honestly believe you can learn quite a lot about a person by watching the way he or she interacts with a person with a disability. In that sense I have found that the conversations which take place before our cameras are often more revealing than the supposedly hard hitting interviews we see on major networks. What I particularly like about this latest film is the chance to watch the way political figures, and the many handlers surrounding them, work so hard to manipulate the way they are portrayed in the media. Often the most interesting part of the interview for us is not the actual interview at all. It's the slightly uncomfortable negotiation which takes place beforehand as we ask them if they will speak with us. I liked being able to include those discussions in this new film. In the past we didn't have the freedom, or good sense, to do that.
Arthur Bradford: Over the years we have endeavored to produce How's Your News in many different ways, as a film festival entry, a DVD, an HBO documentary, and even an MTV series. This latest version, a completely independent, pay-per-view online stream/download, is truly the best form of distribution yet. For those of you who feel frustrated by commercial news media, I really urge you to support this kind of thing. Not to get on a high horse, but hey, this is It's the future of independent media. It's a very good thing.
Boing Boing/XJ: What's it like working with the correspondents?
Arthur Bradford: I've known all of them for so long now, they are some of my oldest friendships. And I do mean friendships. I first met Jeremy when he was just a kid, seven or eight years old. He was a crazy little ball of energy and we all wondered what he was going to be like when he grew up. Would people still think he was cute and charming? He's grown up now and, well, you can decide. Sue calls me up at least once a week, usually more. She is relentless when she's got something on her mind. This latest "How's Your News?" project came about in part because of her prodding. She was leaving messages on my phone saying, "Is this How's Your News horse dead or what? Come on!" Bobby is like an uncle to me. He was an usher at my wedding and plays with my children. I honestly don't know of anyone who can so easily mix and mingle with such a wide array of people. You could take him to a Hell's Angles rally in the morning and he'd have everyone hugging him and then attend a formal White House luncheon an hour later and he'd be cozying up the the Secretary of State. He'd know just how to behave immediately. It's a skill few of us have.
I hold our reporters to a high standard. I often feel like I'm the coach and they are my team. I have to assess who is feeling good and who will interact in the most interesting way with a given interviewee. I sometimes get frustrated with the reporters if they ask banal questions or act shy. I let them know it when I think they can do better. But I never feed them questions. That doesn't come off well. The questions need to come from them. If they are not having a good time and showing genuine curiosity then it's not enjoyable to watch. I find directing How's Your News to be exhausting and draining and usually after each one is done I swear I'll never do it again. But then Sue and Jeremy starting calling me up and we end up hitting the road. And in the end I'm glad we do it.
Download the documentary.
(All images courtesy Arthur Bradford)Sidraž
Sidraž () is a settlement in the Municipality of Cerklje na Gorenjskem in the Upper Carniola region of Slovenia.
Geography
Sidraž is a hill settlement in a shady location east of Šenturška Gora on a saddle between Doblič and Tunjščica creeks. The soil is loamy and there is a spring near the village.
Name
Sidraž was mentioned in historical sources in 1421 as Schydrachs (and as Sidras in 1449, Sydrasch in 1458, and Schidrass in 1475). The name is of unclear origin. A proposed derivation from *suhi draž is very unlikely for phonological reasons, and the village name is more likely based on a truncated personal name.
References
External links
Sidraž at Geopedia
Category:Populated places in the Municipality of Cerklje na GorenjskemThis application is related to co-pending U.S. application Ser. No. 09/429,519 for A METHOD AND APPARATUS FOR COMMUNICATION USING PULSE DECODING, filed Oct. 28, 1999 and to co-pending and co-owned U.S. application Ser. No. 09/805,854 for METHOD AND APPARATUS TO RECOVER DATA FROM PULSES, filed Mar. 13, 2001, both of which are owned by the Assignee of the present invention and are herein incorporated by reference for all purposes.
This invention relates generally to a communication technique and more specifically to techniques for communication by converting arbitrary analog waveforms to sequences of pulses.
In co-pending, commonly owned U.S. application Ser. No. 09/429,519, the communication system illustrated in FIG. 1 shows that groups of pulses are supplied to a decoding (decision) device 14. The decoder disclosed therein recovers data from the pulses; for example, by counting pulses. Additional recovery techniques are disclosed in co-pending, commonly owned U.S. application Ser. No. 09/805,854.
It is desirable to increase the robustness of systems which employ the techniques disclosed in the foregoing identified applications. The utility of such systems can be further increased by increasing their information carrying capacity.
According to the invention, a method and apparatus for a communication circuit is provided to recover information in a received signal. The communication circuit comprises at least two receiver circuits. The received signal is fed to each receiver circuit. Each receiver circuit is configured in accordance with the invention to produce output comprising a group of one or more pulses in response to detecting some portion of the received signal. The output of each receiver is fed to a decision device, which produces one or more symbols.
In one embodiment of the invention, the groups of pulses from each receiver are processed by the decision device to produce a single symbol. In this embodiment of the invention, information transmission is more robust due to the redundancy of the information.
In another embodiment of the invention, the groups of pulses from each receiver are processed to produce a symbol from each such group, thereby enhancing information carrying capacity.Sn Ag Solder
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alternative of lead solders. Generally, commercial tin/silver alloy contains 3%
to 5% silver. The Sn/Ag series solders are widely used in soldering electronic
assemblies; besides, it is applicable for soldering of jewelry due to its
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lead free solder is featured with high melting point and strong thermal
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Sn-Ag solders. The typical product is Sn95Ag5 tin silver
solder wires and bars.Q:
Content Search and Azure how to move items to the bottom of search results with boosting
Similar to my earlier question, I need a way to move certain items to the end of my search results, without using ordering.
I have a checkbox field (currently indexed as a string, containing "1" or "0"). I need the checked items ("1") to be at the bottom of the results.
Normally, it would be possible to do this with ordering, but since I am boosting certain fields, applying ordering operations screws up the result relevancy.
I have a method which adds predicates to my IQueryable object containing:
queryable.Where(item => item["discontinued"].Equals("1").Boost(1.0f)
|| item["discontinued"].Equals("0").Boost(4.0f));
I found from my earlier question that you cannot use negative boost values with Azure search, so I instead tried to give a higher boost for the unchecked items than the checked ones. Is this even possible?: to use two different boost values against the same field depending on the value?. My current testing seems to show that this does not work.
A:
I found this article which shows a similar approach to boosting (see the end of last code sample, toward the bottom) which confirms that my logic was correct.
The error was my choice of boost values.
I am boosting around 15 other fields with values in the range of 24 to 50. I guess that in order for this boost rule to have greater influence than the other ones it needs to be orders of magnitude greater (probably) than the other boost values (this must depend on the number of boosted fields and the frequency of occurrences of search terms). What I found was that upping the boost for non-discontinued items to 1000 fixed the problem. Not a very scientific way to fix the problem, but it seems to work. Note that in my case, I need the discontinued boosting to be used like sorting i.e. to take higher precedence than any of the |
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1975,
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45,
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923,
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281,
253,
12207,
3739,
14,
71,
3178,
474
] | .
The heavy warm gear is turning in my stomach. My hand is the hand of a stranger. Music is still playing. I must have swayed to the music because Winnie Gunn has seized my forearm with both hands.
"Are you all right, Doctor?" she whispers.
"Fine."
"We are still waiting for your diagnosis, Dr. More," says Buddy with the gentleness of victory.
"I found no significant pathology."
"Louder!" from the back benches. The Director cups his ear.
"I said I found no significant pathology."
"No significant pathology," says Buddy as gently as Perry Mason beating Hamilton Burger for the thousandth time. "And what is your recommendation, Doctor?"
"Discharge him."
"Discharge him," repeats Buddy. "He can't walk or talk, and if he could, he would presumably return to his former atrocious behavior. And yet you want to discharge him. As cured, Doctor?"
"If indeed there was nothing wrong with him."
"You think there was nothing wrong with him?"
"No. That is, yes."
"Then what's he doing here in a wheelchair?"
Titters.
I shrug.
"Dr. More, what do you think his chances are of recovering from his stroke?"
"You mean, assuming he's had one."
"Very well. Assuming he's had one."
"Very small."
"And if he did recover, what are the chances he'd return to his former mode of behavior?"
"Very large."
"Do you recall his former behavior?"
I am silent.
"Allow me to refresh your memory, Doctor." Again Buddy flips through the chart. "These," he explains to the amphitheater, "are progress reports during the last year of the patient's residence at the Golden Years Senior Citizen Settlement in Tampa. I quote:
"'The subject has not only refused to participate in the various recreational, educational, creative, and group activities but has on occasion engaged in antisocial and disruptive behavior. He refused shuffleboard tournament, senior softball, Golden Years gymkhana, papa putt-putt, donkey baseball, Guys and Gals à go-go, the redfish rodeo, and granddaddy golf. He refused: free trip to Los Angeles to participate in Art Linkletter III's "the young olds," even though chosen for this trip by his own community.
"'Did on two occasions defecate on Flirtation Walk during the Merry Widow's promenade.
"'Did on the occasion of the Ohio Day breakfast during the period of well-wishing and when the microphone was passed to him utter gross insults and obscenities to Ohioans, among the mildest of which was the expression, repeated many times: piss on all Ohioans!
"'Did in fact urinate on Ohio in the Garden of the Fifty States.
"'Was observed by his neighbors on Bide-a-wee Bayou to be digging furiously with a spade on the patio putt-putt, defacing same. When asked what he was digging for, he replied: the fountain of youth.'"
More titters from the student roosts.
Buddy goes on:
"'Despite extensive reconditioning in the Skinner box, the patient continued to exhibit antisocial behavior. This behavior,'" Buddy hastens to add, "'Occurred before his stroke last month.'"
"If he had a stroke," I say.
"If he had a stroke," Buddy allows gravely. "Well, Doctor?"
"Well what?"
"What would you do with him?"
"Discharge _him_."
"To suffer another thirty years?" asks Buddy, smiling. "To cause other people suffering?"
"At least he'd have a sporting chance."
"A sporting chance to do what?"
"To avoid your packing him off to Georgia, where they'd sink electrodes in his head, plant him like a carrot in that hothouse which is nothing more than an anteroom to the funeral parlor. Then throw the Euphoric Switch—"
"Doctor!" interrupts the Director sternly.
"Aaah!" The students blush at the word _funeral_. Girls try to pull their dresses down over their knees.
Buddy flushes angrily.
The Director is angrier still.
"Doctor!" He levels a quivering finger at me, then crooks it, summoning me. Craning down, he croaks into my ear. "You know very well that the patient is present and that there is no guarantee that he cannot understand you."
"Excuse me, sir, but I hope—indeed I have reason to believe—that he does understand me."
The Director goes off into a fit of coughing. His eyes bulge glassily. Handkerchiefs fly in and out of plackets in his coat. The students are in an uproar. Cheers from the Knotheads, boos from the Lefts.
"This is too much!" The Director throws up both hands. Now he's grabbed me, hooked me with his claws like the ancient mariner. "It's my mistake, Doctor," he croaks. "My putting you on patient-staff status. I beg your pardon. It is only too clear that your illness does not yet permit you to function."
"I can function, sir," I tell him, speaking into his great hairy convoluted ear. "You'll see."
"Be careful, Doctor!" The powerful old hands squeeze my arm by way of warning. "Proceed!"
Mr. Ives's bright monkey eyes have begun to snap again.
"I repeat," I say to the back rows. "If Mr. Ives is going to be referred to Happy Isles of Georgia, which is nothing but a euthanasia facility, he has the right to know it and to prepare himself accordingly. And he has the right to know who his executioner is."
"I warned you, Doctor!" The Director is on his feet and shouting. "Perhaps you'd better go back to the ward, to A-4."
"Yes sir," I say. Perhaps he is right.
The students, struck dumb, gaze at me, gaze at each other.
"Sir!"
It is Buddy, advancing toward me, hands clasped behind his back. He holds one hand up to quiet the uproar. The other hand is still behind him. "Sir!"—to the Director, in a loud voice. "I submit to you, sir, that you are mistaken!"
"Eh?" The Director cups his ear.
"Sir, you do an injustice both to Dr. More as well as to your own clinical judgment!"
"Eh? How's that?"
"Your first decision about Dr. More was quite correct. Your confidence in him is not misplaced. His illness does not in the least interfere with his functioning. In short, sir, I submit to you that his odd behavior today cannot be laid to his illness at all. The truth is—" Buddy, quick as a cat, steps behind me, embraces me with one arm, with the other hidden hand claps a mask over my face. His grip is like iron. There is nothing to do but squirm and, at length, gasp for breath. Three, four, five seconds and Buddy flings one arm up like a cowboy bulldogging a steer. He holds the dial aloft for all to see, presents it to the Director like the bull's ears. "Point three percent ethyl alcohol. The truth is Dr. More is drunk as a lord!"
Relieved laughter from the students—along with the gasps. At least they recognize a familiar note of buffoonery.
Even the Director looks relieved despite himself.
"Fun is fun," he announces to no one in particular. "But The Pit may be getting out of hand."
Moira has shrunk even farther into the tunnel.
Unbuckling my physician's bag, I take out my modified lapsometer. Buddy makes way for me, giving my arm a friendly squeeze, handing me on to the patient with a reassuring smile. _You see,_ his smile tells the students, _it's all in the spirit of The Pit. More and I are not mad at each other._
"Your patient, Doctor." Your witness, Mr. Burger. Twenty years and Ham Burger never won a case.
"Thank you, Doctor, but I don't want the patient. I want you."
A beehive murmur. Buddy holds up both hands.
"It's all right!" he cries, smiling. "Turnabout is fair play. Dr. More is going to diagnose me. Why not? He is going to measure, not my blood alcohol, but my metaphysical status. The device he holds there—correct me if I'm wrong, Doctor—is the More Quantitative-Qualitative Ontological Lapsometer."
Laughter from the left.
"Qualitative-Quantitative," I correct him.
More laughter from the left. Consternation from the right benches. Stony stares from my colleagues. But the Director's glossy eyes bulge amiably—at least he is relieved to see the tone change to the acceptable medical-farcical |
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] | }) complexes.](c6sc00462h-s1){#sch1}
Results
=======
Design and synthesis of ligands and complexes
---------------------------------------------
In previous study, we reported a series of Pd([ii]{.smallcaps}) complexes supported by \[O\^N\^C\^N\] ligands that show an intense green phosphorescence (*Φ*~em~ up to 22%) with a long *τ*~obs~ (up to 122 μs) at room temperature. These \[Pd(O\^N\^C\^N)\] complexes were found to sensitize triplet--triplet annihilation (TTA) of 9,10-diphenylanthracene (DPA) (*Φ*~delayed\ fluorescence~ of up to 21%), catalyse photo-induced aerobic oxidation of secondary amines with up to 1650 turnovers in 2 h, and serve as a phosphorescent dopant in OLEDs with an EQE of up to 7.4%.[@cit9] As the ligand structure has a profound effect on the photophysical and photochemical properties of the metal complex, a new panel of tetradentate ligands have been prepared and used for preparing highly luminescent Pd([ii]{.smallcaps}) complexes. **Pd-G-1** was designed by modification of the reported \[Pd(O\^N\^C\^N)\] complexes by replacing the *n*-butyl with methyl groups.[@cit9] This modification is envisaged to lead to shorter intermolecular contact. **Pd-N-1** features a bridging tertiary amine between the phenyl and terminal pyridine groups of the \[O\^N\^C\^N\] ligand resulting in a 6-5-6-membered metallocycle. Complexes **Pd-B-1**, **Pd-B-3** and **Pd-B-4** have a \[N\^C\^C\^N\] ligand scaffold containing a spiro-fluorene group installed between a phenyl ring and a pyridine ring.
The tetradentate ligands of complexes **Pd-N-1**, **Pd-B-1** and **Pd-B-3** were prepared by the procedures depicted in [Scheme 2](#sch2){ref-type="fig"} (the synthetic procedure for the ligand of **Pd-B-4** can be found in the ESI[†](#fn1){ref-type="fn"}). The Pd([ii]{.smallcaps}) complexes were synthesized by reacting the corresponding ligands with Pd(OAc)~2~ in refluxing CH~3~CO~2~H, and were purified by flash column chromatography on a SiO~2~ column using a hexane--ethyl acetate mixture as eluent. The ^1^H NMR data of all reaction intermediates, ligands and metal complexes are given in the ESI.[†](#fn1){ref-type="fn"} Assignments of the ^1^H signals are based on 2D COSY and NOESY NMR spectra. Complexes **Pd-B-1**, **Pd-B-3** and **Pd-B-4** show a downfield ^1^H signal at ∼10 ppm assignable to protons on the spiro-fluorene unit. The ^1^H NMR spectra of **Pd-B-1** at a temperature of 273--323 K are depicted in Fig. S1 of the ESI.[†](#fn1){ref-type="fn"} All the ^1^H signals retain their chemical shifts except that the protons on the spiro-fluorene become broader at temperatures \>313 K. Thermal stability of **Pd-B-1**, **Pd-B-2**, **Pd-B-4**, **Pd-G-1**, **Pd-G-2** and **Pd-N-1** has been investigated by thermogravimetric analysis (TGA). Except for **Pd-B-4**, all the complexes show a decomposition temperature (*T*~d~) at 315 to 392 °C (Fig. S2 in the ESI[†](#fn1){ref-type="fn"}). High purity samples of **Pd-B-1**, **Pd-B-2**, **Pd-G-1** and **Pd-G-2** were obtained by sublimation at 285 to 300 °C under 4 × 10^--5^ Torr. The structures of **Pd-B-1** and **Pd-B-3** were characterized by X-ray crystallography.
{#sch2}
X-ray crystal structure of **Pd-B-1** and **Pd-B-3**
----------------------------------------------------
Crystals of **Pd-B-1** and **Pd-B-3** were obtained by slow diffusion of Et~2~O into CHCl~3~ solutions of the metal complexes. Their X-ray crystal structures ([Fig. 1](#fig1){ref-type="fig"} and S3[†](#fn1){ref-type="fn"}) reveal a distorted coordination geometry from planarity with C~phenyl~-Pd-N~pyridine~ angles of 165.96(7)--173.74(8)°. The Pd--N distances of 2.0968(19)--2.1441(18) Å are longer than those of the reported \[Pd(O\^N\^C\^N)\] complexes (1.982(1)--2.061(3) Å).[@cit9] The spiro-fluorene moiety forces the pyridine ring nearby to twist at an angle of ∼52.2° (**Pd-B-1**) or ∼54.4° (**Pd-B-3**) to the normal plane of the Pd1--C11--C6--C5--N1 (**Pd-B-1**) or Pd1--C6--C7--C5--N1 (**Pd-B-3**) ring, resulting in a highly distorted, rigid ligand scaffold (inset in [Fig. 1](#fig1){ref-type="fig"} and S3[†](#fn1){ref-type="fn"}). It is noted that the hydrogen atoms residing on C25 (**Pd-B-1**) and C42 (**Pd-B-3**) point toward the Pd1--C11--C6--C5--N1 (**Pd-B-1**) and Pd1--C6--C7--C5--N1 (**Pd-B-3**) chelating rings, respectively, with a distance separation of 2.543--2.556 Å ([Fig. 1](#fig1){ref-type="fig"} and S3[†](#fn1){ref-type="fn"}). There is no close Pd···Pd contact in the crystal structures.
{#fig1}
Electrochemical properties of Pd([ii]{.smallcaps}) complexes
------------------------------------------------------------
The electrochemical data of the Pd([ii]{.smallcaps}) complexes in DMF (0.1 mol dm^--3\ *n*^Bu~4~NPF~6~ as the supporting electrolyte) are summarized in [Table 1](#tab1){ref-type="table"}. Cyclic voltammograms of **Pd-N-1**, **Pd-B-1**, **Pd-B-2**, **Pd-B-4**, **Pd-G-1**, and **Pd-G-2** in DMF show a quasi-reversible reduction couple at *E*~1/2~ of --2.16 to --2.54 V and an irreversible oxidation wave at *E*~pa~ of +0.53 to +0.81 V *versus* Cp~2~Fe^+/0^ ([Fig. 2](#fig2){ref-type="fig"} and S4[†](#fn1){ref-type="fn"}). **Pd-N-1** shows a similar *E*~pa~ value (∼+0.53 V) but a more cathodic *E*red1/2 (*E*red1/2 with a cathodic shift of 260 mV) compared to those of **Pd-G-1** and **Pd-G-2**. The less cathodic *E*red1/2 of **Pd-G-1** and **Pd-G-2** is ascribed to the two electron-withdrawing F substituents on the \[O\^N\^C\^N\] ligand of **Pd-G-1** and **Pd-G-2** which cause lowering of the LUMO of these two complexes when compared to **Pd-N-1**. On the other hand, complexes **Pd-N-1**, **Pd-G-1**, and **Pd-G-2** have similar *E*~pa~ values attributable to their HOMOs being mainly localized on the phenoxide ion of the \[ |
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] | =ints[1]&1;}staticvoid__initramdisk_size(char*str,int*ints){if(ints[0]>0 &&ints[1]>=0)rd_size=ints[1];}#endifstaticint__initchecksetup(char*line){inti,ints[11] ;#ifdefCON FIG _ B L K _ D E V _ I D E/ * i d e d r i v e r n e e ds t he b a s i cs tri n g , r ath e rtha npre-processedvalues*/if(!s trncmp(line,"ide",3)||(!strncmp(line,"hd",2)&&line[2]!='=')){ide_setup(line);re turn1;}#endiffor(i=0;raw_params[i].str;i++){intn=strlen(raw_params[i].str);if(!strncmp (line,raw_ p a r a m s [ i ] . s t r , n ) ){ ra w _ p a ra m s [ i ].setup_ fu nc(li n e + n, N U L L ) ; return1;}}for(i=0;cooked_p arams[i].str;i++){intn=strlen(cooked_params[i].str);if(!strncmp(line,cooked_par ams[i].str,n)){cooked_params[i].setup_func(get_options(line+n,ints),ints);return1;}}re turn0;}/*t h i s s h o u l d b e a p p r o x 2 B o * o M i p st o st a r t ( not e i ni t i a lsh i f t ) , a n d w i llstillworkevenifinitiall ytoolarge,itwilljusttakeslightlylonger*/unsignedlongloops_per_sec=(1<<12);/*Thi sisthenumberofbitsofprecisionfortheloops_per_second.Eachbittakesonaverage1.5/HZseconds .This(lik e t h e o r i g i n a l ) i s a l i tt l e b e t t er tha n 1%* / #d ef ineLPS_PREC 8 v o i d _ _ i nitcalibrate_delay(void ) { unsignedlongticks,loopbit;intlps_precision=LPS_PREC;loops_per_sec=(1<<12);prin tk("Calibratingdelayloop...");while(loops_per_sec<<=1){/*waitfor"startof"clocktick*/ti cks=jiff i e s ; w h i l e (t i c k s= = j if f i e s) / *not h ing * /;/ *G o . . * /t i c k s = ji f f i e s ; _ _ delay(loops_per_sec);tic ks=jiffies-ticks;if(ticks)break;}/*Doabinaryapproximationtogetloops_per_second settoequaloneclock(uptolps_precisionbits)*/loops_per_sec>>=1;loopbit=loops_per_sec;whi le(lps_ p r e c i s i o n -- && ( l o o p b i t> > = 1 ) ) { loo p s _ p er_ s e c| =loo p bit;ti c k s=j i f f i es;while(ticks==jiffies) ;ticks=jiffies;__delay(loops_per_sec);if(jiffies!=ticks)/*longerthan1tick*/loo ps_per_sec&=~loopbit;}/*finally,adjustloopspersecondintermsofsecondsinsteadofclocks*/l oops_p e r _s e c * = H Z ; / * R o u n d t h e va l u e a n d pr int i t*/ p r in tk ( "%lu. % 02 l uB o goM I P S \ n",(loops_per_sec+2500) /500000,((loops_per_sec+2500)/5000)%100);}/**Thisisasimplekernelcommandlinepar singfunction:itparses*thecommandline,andfillsinthearguments/environmenttoinit*asapprop riate. A n y c m d - l i n e o p t i on i s t a k e n t o b eane n v ironm ent *v a ri a bleifitco n t a i n s t h echaracter'='.**Thisro u tinealsochecksforoptionsmeantforthekernel.*Theseoptionsarenotgiventoinit-theya reforinternalkerneluseonly.*/staticvoid__initparse_options(char*line){char*next;intarg s,env s ; if ( ! * l i n e ) r et u r n; a r g s = 0 ; e n vs= 1;/ * TER Mi ssetto'l i n u x'by d e f a u l t * / n ext=line;while((line=ne xt)!=NULL){if((next=strchr(line,''))!=NULL)*next++=0;/**checkforkerneloptionsf irst..*/if(!strcmp(line,"ro")){root_mountflags|=MS_RDONLY;continue;}if(!strcmp(line,"r w")){ r o o t _ mo u n t f l a g s & = ~ M S _ R D O N L Y ; co nt i n u e ; } if(!s t rc m p(line , "d e b u g ") ) { console_loglevel=10;cont inue;}if(!strncmp(line,"init=",5)){line+=5;execute_command=line;/*IncaseLILOis goingtobootuswithdefaultcommandline,*itprepends"auto"beforethewholecmdlinewhichmakes*t heshe l l t h i n k i t s h o u l d e x ecut e a s c ri ptw it h suc hn am e .*S o weigno r e a l l a r g u m e n t s entered_before_init=... [MJ]*/args=0;continue;}if(checksetup(line))continue;/**Thencheckifit'sanenviro nmentvariableor*anoption.*/if(strchr(line,'=')){if(envs>=MAX_INIT_ENVS)break;envp_init [++en v s ] = l i ne ; } e lse { i f ( a r g s > = M A X _ I NI T _A R G S)brea k ;arg v _ i ni t [ + + a r g s ] = l i ne;}}argv_init[args+1]=N ULL;envp_init[envs+1]=NULL;}externvoidsetup_arch(char**,unsignedlong*,unsigned long*);#ifndef__SMP__/**Uniprocessoridlethread*/intcpu_idle(void*unused){for(;;)idle() ;}#de f i n e s m p _ i n it ( ) d o{ } whi l e ( 0 ) #el s e /* *M ul t i p r oces s or i dle t h r ead i s i n a r ch/...*/externintcpu_idle (void*unused);/*Calledbybootprocessortoactivatetherest.*/staticvoid__initsmp_ init(void){/*Getotherprocessorsintotheirbootupholdingpatterns.*/smp_boot_cpus();smp_th reads _ r e a d y = 1 ; s m p _ c o m m e n c e ( ) ; } # e ndifex te rnvoidin i ti a liz e _ s ec o n d a r y ( v o id);/**Activatethefirstpro cessor.*/asmlinkagevoid__initstart_kernel(void){char*command_line;#ifdef__SM P__staticintboot_cpu=1;/*"current"hasbeensetup,weneedtoloaditnow*/if(!boot_cpu)initial ize_s e co n d a r y ( ) ; bo ot _ c p u =0 ; # e n d if/ * * In te r ru p ts a re s t i l l d i s a b l e d . Do n e c e ssarysetups,then*enablethe m*/printk(linux_banner);setup_arch(&command_line,&memory_start,&memory_end); memory_start=paging_init(memory_start,memory_end);trap_init();init_IRQ();sched_init(); time_ i n i t ( ) ; p ar s e _ o p t i o n s( c o m m an d_ l in e) ; /**H A CKA L E R T ! T h i s i s |
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The company may need to set aside funds for a US$16.7 million note maturing in November, apart from as much as US$110 million maturing next April, according Raymond James analyst Andrew Bradford, although lenders are expected to provide debt relief.
“Lenders would be far better off to amend covenants and work with operators through the downturn if for no other reason than equipment liquidated through a receiver could effectively go ‘no-bid’ in today’s market,” Bradford said in a note.
Much-needed cash may be generated with the sale of its Russian and Kazakhstan pressure pumping business, which analysts said could fetch between $50 million and $200 million. The company would not divulge details on the unsolicited offer, nor a timeline of when a possible deal could be concluded.
“We believe the most likely buyer is Rosneft and Trican is likely to realize cash proceeds of $175 million-$200 million in the context of the current market,” CIBC’s Morrison said, based on the assumption that 85 per cent of the $242 million generated from Trican’s international business is estimated to be from the region.
Industry indicators suggest more pain is on the way for oilfield services companies.
“The full impact of throttled back E&P spending was felt in April, with wells drilled and completions down 62 per cent and 74 per cent year-on-year, respectively,” said Dan MacDonald, analyst at RBC Dominion Securities Inc.
Well completions were down 74 per cent in April year-on-year, fracturing-intensive gas well completion activity was down 51 per cent versus last year, and oil well completions were down 80 percent.
Trican peer Ensign Energy Services Inc. recently described the upcoming summer in Canada as “very tough” and said it expects to use only a fourth of its equipment.
Meanwhile, Precision Drilling Corp. has negotiated relief for the two principal covenants of its revolving credit facility.
“We are entering a cyclical downturn that will parallel 2009 and in some cases, will be worse than 2009,” Morrison said. “First quarter was the start and Q2 will be much worse while Q3 and Q4 will be depend on commodity prices getting better.”Responding to Simkulet's objections to the two tragedies argument.
The two tragedies argument (2TA) has been raised as a response to the argument against abortion from spontaneous abortion (or miscarriages). According to this argument against the antiabortion position (AAP), miscarriages should be of great concern for proponents of this position since they result in a greater amount of deaths of human beings than induced abortions do. According to critics of AAP, this fact undermines its plausibility, since proponents of the AAP either must try to prevent miscarriages to the same extent as they try to prevent abortions or abandon their opposition to at least some abortions-which are not acceptable options for proponents of APP. The claim of 2TA is that one can differentiate between induced abortion and miscarriages due to the fact that the former involves the act of killing of another human being. This fact adds a tragedy to the tragedy that both abortions and miscarriages result in - the death of a human being - and contributes to justifying the choice of proponents of AAP to prioritise the prevention of abortions rather than miscarriages. In this response, I defend 2TA against criticism that claims that this argument is: (1) inconsistent with the AAP and (2) trivialises the death of the fetus. My claim is that the first line of criticism rests on a misunderstanding of the premises of 2TA while the second line of criticism rests on a disanalogous thought experiment. I therefore conclude that these objections fail.Q:
Airflow ExternalTaskSensor execution timeout
I'm using airflow.operators.sensors.ExternalTaskSensor to make one Dag wait for another.
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},
template_searchpath="%s/me/resources/" % DAGS_FOLDER,
schedule_interval="{} {} * * *".format(minute, hour),
max_active_runs=1
)
wait_for_dag1 = ExternalTaskSensor(
task_id='wait_for_dag1',
external_dag_id='dag1',
external_task_id='dag1_task1',
dag=dag
)
If something seriously wrong happens with upstream Dag and it fails to complete during the given time period, I want upstream Dag (ExternalTaskSensor operator) crash as well, instead of hanging forever.
How can I add a timeout to ExternalTaskSensor?
I'm looking into documentation, but it does not seem to have a timeout parameter or something similar. What should I do?
https://airflow.readthedocs.io/en/stable/_modules/airflow/sensors/external_task_sensor.html
A:
The ExternalTaskSensor does take a timeout argument in seconds. It inherits the argument from BaseSensorOperator (https://airflow.apache.org/_modules/airflow/sensors/base_sensor_operator.html). If you pass it timeout=60 on instantiation, it will fail after 60 seconds.
/*--------------------------------*- C++ -*----------------------------------*\
| ========= | |
| \\ / F ield | OpenFOAM: The Open Source CFD Toolbox |
| \\ / O peration | Version: 2.3.0 |
| \\ / A nd | Web: www.OpenFOAM.org |
| \\/ M anipulation | |
\*---------------------------------------------------------------------------*/
FoamFile
{
version 2.0;
format ascii;
class volScalarField;
location "0";
object Ydefault;
}
// * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * //
dimensions [0 0 0 0 0 0 0];
internalField uniform 0.0;
boundaryField
{
fuel
{
type fixedValue;
value uniform 0.0;
}
air
{
type fixedValue;
value uniform 0.0;
}
outlet
{
type inletOutlet;
inletValue uniform 0.0;
value uniform 0.0;
}
frontAndBack
{
type empty;
}
}
// ************************************************************************* //
``defined``
===========
``defined`` checks if a variable is defined in the current context. This is very
useful if you use the ``strict_variables`` option:
.. code-block:: twig
{# defined works with variable names #}
{% if foo is defined %}
...
{% endif %}
{# and attributes on variables names #}
{% if foo.bar is defined %}
...
{% endif %}
{% if foo['bar'] is defined %}
...
{% endif %}
When using the ``defined`` test on an expression that uses variables in some
method calls, be sure that they are all defined first:
.. code-block:: twig
{% if var is defined and foo.method(var) is defined %}
...
{% endif %}
Q:
Android : How to stop all threads start in fragment when change fragment
I have an activity with many fragments inside. In one fragment, I run some periodically thread that use some command such as getActivity().runOnUiThread(), so when switch to different fragmemnt, those statement will make NullPointException.
I know how to stop a thread, but don't know which method to put this code inside. (it means: when switch fragment, which method that fragment will always run before switch).
Please help me about this problem.
Thanks :)
A:
Thanks to help of Leco. The best way is put those code into onPause.
You can see more detail in this link: Fragment Lifecycle
Help this post will useful for anyone meets same problem with me.
Q:
Are the total false positives and false negatives of |
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] | \int_{\mathbb{R}}\nabla \rho_{{\varepsilon},r,r_0} \cdot (2\nabla
-({D_+}+ {D_-})\rho_{{\varepsilon},r,r_0}^{{\Delta x}}\,d\zeta.$$ Then there exists a constant $C = C(d,J)$ such that $${\left\|U\right\|}_{L^1(\Pi_T^{r_0})}
\le C\frac{{{\Delta x}}^2}{r^3}\left(1 +
\frac{{{\Delta x}}}{r}\right){\left\|A(u_{{\Delta x}})\right\|}_{L^1([0,T];BV({\mathbb{R}}^d))}.$$
The $BV$ norm may be replaced by the $L^1$ norm at the expense of an extra factor $r^{-1}$.
Clearly, $$\begin{gathered}
{\left\|\int_{\mathbb{R}}\nabla \rho_{{\varepsilon},r,r_0} \cdot
(2\nabla -({D_+}+ {D_-})\rho_{{\varepsilon},r,r_0}^{{\Delta x}}\,d\zeta\right\|}_{L^1(\Pi_T^{r_0})}
\\
\le {\left\|\nabla \rho_{{\varepsilon},r,r_0}\right\|}_{L^\infty(\Pi_T^{r_0} \times
{\mathbb{R}};{\mathbb{R}}^d_\infty)}{\left\|(2\nabla -({D_+}+
{D_-})\rho_{{\varepsilon},r,r_0}^{{\Delta x}}\right\|}_{L^1(\Pi_T^{r_0} \times {\mathbb{R}};{\mathbb{R}}^d_1)}.
\end{gathered}$$ By Young’s inequality for convolutions, $$\begin{aligned}
{\left\|\partial_{x_i}\rho_{{\varepsilon},r,r_0}\right\|}_{L^\infty(\Pi_T^{r_0} \times {\mathbb{R}})}
&\le {\left\|\chi(A(u);\cdot)\right\|}_{L^\infty(\Pi_T \times
{\mathbb{R}})}{\left\|J_{\varepsilon}\otimes \partial_{x_i}J_r \otimes
J_{r_0}\right\|}_{L^1({\mathbb{R}}\times {\mathbb{R}}^d \times {\mathbb{R}})} \notag
\\
&\le {\left\|\partial_{x_i}J_r\right\|}_{L^1({\mathbb{R}}^d)} \le 2{\left\|J'\right\|}_\infty r^{-1}.
\end{aligned}$$ We have $$(2\partial_{x_i} -({D_+}^i + {D_-}^i))\rho_{{\varepsilon},r,r_0}^{{\Delta x}}=
\chi(A(u_{{\Delta x}});\cdot) \star J_{\varepsilon}\otimes
(2\partial_{x_i} -({D_+}^i + {D_-}^i))J_r \otimes J_{r_0}.$$ Using Taylor expansions with remainders, $$\begin{aligned}
\left(({D_+}^i + {D_-}^i)-2\partial_{x_i}\right)J_r(x)
&= \frac{1}{2{{\Delta x}}}
\int_0^{{{\Delta x}}}(z-{{\Delta x}})^2 \partial_{x_i}^3J_r(x_i+z)\,dz
\,\prod_{j \neq i}J_r(x_j)
\\
&\qquad + \frac{1}{2{{\Delta x}}}
\int_{-{{\Delta x}}}^0(z+{{\Delta x}})^2 \partial_{x_i}^3J_r(x_i+z)\,dz
\,\prod_{j \neq i}J_r(x_j)
\\
&=: \partial_{x_i}(\varphi^i_1(x) + \varphi^i_2(x)),
\end{aligned}$$ see for instance [@KRS2014 p. 25]. Hence $$(2\partial_{x_i} -({D_+}^i + {D_-}^i))\rho_{{\varepsilon},r,r_0}^{{\Delta x}}= \partial_{x_i}\left(\chi(A(u_{{\Delta x}});\cdot) \star J_{\varepsilon}\otimes
(\varphi^i_1 + \varphi^i_2) \otimes J_{r_0}\right).$$ By Young’s inequality for convolutions $$\begin{gathered}
{\left\|(2\partial_{x_i} -({D_+}^i +
{D_-}^i))\rho_{{\varepsilon},r,r_0}^{{\Delta x}}\right\|}_{L^1(\Pi_T^{r_0} \times {\mathbb{R}})}
\le {\left\|\chi(A(u_{{\Delta x}});\cdot)\right\|}_{L^1([0,T] \times {\mathbb{R}};BV({\mathbb{R}}^d))}\\
\times {\left\|\varphi^i_1 + \varphi^i_2\right\|}_{L^1({\mathbb{R}}^d)}.
\end{gathered}$$ Note that ${\left\|\chi(A(u_{{\Delta x}});\cdot)\right\|}_{L^1([0,T] \times
{\mathbb{R}};BV({\mathbb{R}}^d))} = {\left\|A(u_{{\Delta x}})\right\|}_{L^1([0,T];BV({\mathbb{R}}^d))}$. Now, as $\partial_{x_i}J_r(x_i + z) \le r^{-3}
{\left\|J''\right\|}_\infty{\mathds{1}_{{\left|x_i+ z\right|} \le r}}$, it follows that $$\begin{aligned}
{\left\|\varphi^i_1\right\|}_{L^1({\mathbb{R}}^d)} &= \frac{1}{2{{\Delta x}}}\int_{\mathbb{R}}\Bigl|\int_0^{{{\Delta x}}}(z-{{\Delta x}})^2 \partial_{x_i}^2J_r(x_i+z)\,dz\Bigr|\, dx_i
\\
&\le \frac{(r + {{\Delta x}})}{{{\Delta x}}r^3}{\left\|J''\right\|}_\infty\int_0^{{{\Delta x}}}(z-{{\Delta x}})^2\,dz
\\
&\le \frac{1}{3}{\left\|J''\right\|}_\infty \frac{{{\Delta x}}^2}{r^2}\left(1 +
\frac{{{\Delta x}}}{r}\right).
\end{aligned}$$ The same estimate applies to $\varphi_2^i$.
\[est:5\] Let ${\mathscr{T}}$ be the term from Lemma \[lemma:ContractionLemma\], that is, $${\mathscr{T}}= \int_R ({\mathrm{sign}_\varepsilon\left(\zeta-A(u)\right)} \star J_{r_0} \otimes
J_r)(\Delta - {D_-}\cdot {D_+})\rho_{{\varepsilon},r,r_0}^{{\Delta x}}\,d\zeta.$$ Then there exists a constant $C = C(d,J)$ such that $${\left\|{\mathscr{T}}\right\|}_{L^1(\Pi_T^{r_0})} \le C\frac{{{\Delta x}}^2}{r^3}\left(1 +
\frac{{{\Delta x}}}{r}\right){\left\|A(u_{{\Delta x}})\right\|}_{L^1([0,T];BV({\mathbb{R}}^d))}.$$
At the cost of an extra factor $r^{-1}$, the $BV$ norm may be replaced by the $L^1$ norm.
First note that ${\left|{\mathrm{sign}_\varepsilon\left(\zeta-A(u)\right)} \star J_{r_0} \otimes J_r\right|}
\le 1$, so $${\left|{\mathscr{T}}\right|} \le {\left\|(\Delta - {D_-}\cdot
{D_+})\rho_{{\varepsilon},r,r_0}^{{\Delta x}}\right\|}_{L^1(\Pi_T \times {\mathbb{R}})}.$$ Now, $$(\partial_{x_i}^2 - {D_-}^i{D_+}^i)\rho_{{\varepsilon},r,r_0}^{{\Delta x}}= \chi(A(u_{{\Delta x}});\cdot) \star J_{\varepsilon}\otimes (\partial_{x_i}^2 -
{D_-}^i{D_+}^i)J_r \otimes J_{r_0}.$$ Using a Taylor expansion [@KRS2014 p.24], $$\begin{aligned}
(\partial_{x_i}^2-{D_-}^i{D_+}^i)J_r(x)
&= \frac{1}{6{{\Delta x}}^2}\int_0^{{\Delta x}}(z-{{\Delta x}})^3\partial_{x_i}^4J_r(x_i +
z)\, |
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] | in order to perform the task by legislation. Moreover, the act sets forth in sufficient exactness the things to be considered by the Department in reaching its determinations. It sets forth just who shall be liable under the act and how the Department shall determine their liability. The act provides for an administrative hearing at the instance of any person affected or aggrieved by the administration of the act, and allows judicial review under the Administrative Review Act of any final decision of the Department. (See Sheldon v. Hoyne, 261 Ill. 222.) The discretion allowed the Department is therefore far from arbitrary, being subject to all these limitations, rules, and provisions of law.
*422 After a careful examination of sections 19 to 25 of article IX, inclusive, of the Mental Health Code, we are of the opinion that none of these sections are vulnerable to the constitutional objections advanced and that the superior court of Cook County erred in holding those sections of the statute unconstitutional and in enjoining their enforcement.
The decree of the superior court of Cook County is therefore reversed and the cause is remanded, with directions to vacate the decree heretofore entered and to dismiss plaintiffs' suit for want of equity.
Reversed and remanded, with directions.
Mr. JUSTICE SCHAEFER took no part in the consideration or decision of this case.
Effect of nonspecific interactions of the hepatitis B surface antigen with the solid phase on its detection by two-site immunoradiometric assay.
Two-site immunoradiometric assay (Austria II-125, procedure B, Abbott) was used to detect hepatitis B surface antigen (HBsAg) in chronic carrier sera from clinically healthy subjects or from kidney transplant or hemodialysis patients. The titration curves of some high-titered sera showed a prozone-like effect; this corresponded in two such sera LB and MA, to congruent to 80% inhibition of HBsAg detection in undiluted serum relative to a 1:800 dilution. The nature of the inhibition in the above two sera was investigated. We found that the inhibition depended on the time of first incubation but not on the affinity of capture antibodies. Nonspecific adsorption of HBsAg to the solid phase during the first incubation with inhibitory sera and elution of the thus adsorbed antigen during the second incubation, with the resulting neutralization of 125I-labeled anti-HBs, appeared to cause the inhibition of detection observed. The inhibition was prevented by addition of the detergent Triton X-100 to serum or by elution of adsorbed antigen prior to the second incubation, thus indicating that further improvements of the HBsAg immunoradiometric assay may be possible.
239 A.2d 215 (1968)
The STATE of Delaware
v.
Willle Lee JACKSON.
Superior Court of Delaware, New Castle.
February 16, 1968.
*216 Francis A. Reardon, Deputy Atty. Gen., for the State.
Henry A. Wise, Jr., Wilmington, for defendant.
OPINION
CHRISTIE, Judge.
The defendant was arrested for the possession and sale of marijuana following the search of his premises pursuant to a search warrant. Thereafter, the defendant was indicted for the sale and possession of "a narcotic drug, to-wit: Marijuana" in violation of 16 Del.C. § 4702(a). Subsequently, the defendant moved to suppress the evidence obtained by the search warrant on the ground that the warrant authorized a search for narcotic drugs and the return showed marijuana had been seized, which defendant contends is not a narcotic drug.
The defendant also moved to dismiss the indictment on two grounds: 1) the statute under which the indictment was brought is unconstitutional in that it includes in the body a subject not set forth in the title of the act in violation of Article 2, Section 16 of the Delaware Constitution, Del. C.Ann. and, 2) the indictment failed to advise the defendant of the offense charged because the statute on which it is based prohibits the sale and possession of many substances the legislature did not intend to prohibit.
The statute under which the defendant was indicted is 16 Del.C. § 4702(a). This Section was originally enacted as a part of the Delaware Narcotic Drug Act adopted on April 18, 1935 as 40 Del.Laws Ch. 225.
The title of the Narcotic Act read in pertinent part: "An Act Defining and Relating to Narcotic Drugs and the use thereof Regulating and Prohibiting the Manufacture, Possession, Control, Sale; * * *." The body of the act when enacted and as reenacted in the Code in 1953 defines marijuana as a narcotic drug.
The defendant contends the above quoted title is unconstitutional because it violates Article 2, Section 16 of the Delaware Constitution which provides that:
"No bill or joint resolution except bills appropriating money for public purposes, shall embrace more than one subject, which shall be expressed in its title."
Defendant's contention is that marijuana is not a narcotic drug, and therefore, is not a subject which can be included within the statute, the title of which indicates that narcotics is the subject dealt with.
The first question is whether the defendant may properly challenge the constitutionality of a title to an act the provisions of which were subsequently reenacted as part of the Delaware Code. Such a challenge has been entertained but only in cases where the significance of the reenactment as part of the Delaware Code was not raised or decided. Randolph v. Wilmington Housing Authority, 37 Del.Ch. 202, 139 A. 2d 476 (1958), State of Delaware v. Chase, 11 Terry 383, 131 A.2d 178 (1957).
The title of the act by which the Delaware Code was adopted in 1953 has been held to be sufficient to meet the constitutional requirements of Article 2, Section 16 of the State Constitution. Monacelli v. Grimes, 9 Terry 122, 99 A.2d 255 (1953). The title of the act adopting the Delaware Code necessarily covers the statutes, acts and laws included therein at the date of its adoption. Since the title of the Delaware Code is adequate for the entire Code and meets constitutional requirements an attack on the validity of a title of an act which was reenacted as part of the Delaware Code is futile. State v. Durham, Del.Super., 191 A.2d 646 (1963).
If the defendant were permitted to attack the title of an act which was enacted prior to the Delaware Code and later reenacted as a part thereof, an issue then might arise as to whether the title was *217 adequate. This in turn might depend on whether or not marijuana is a narcotic drug within the accepted meaning of the term.
Questions similar to this have been raised in other jurisdictions which, like Delaware, have included provisions as to marijuana in their narcotic laws. Wherever the issue has been raised it has been held in effect that marijuana is a narcotic drug for purposes of statutory interpretation. Spence v. Sacks, 173 Ohio St. 419, 183 N. E.2d 363 (1962); People v. Stark, 157 Colo. 59, 400 P.2d 923 (1965); Commonwealth v. Leis and Weiss, Mass.Superior Court No. 28841-1 (1967); Gonzales v. State, 163 Tex.Cr.R. 432, 293 S.W.2d 786 (1956); People v. Rumley, 100 Cal.App.2d 6, 222 P.2d 913 (1950); Escobio v. State, Fla., 64 So.2d 766 (1953).
Under Delaware decisional law, the constitutional provision in question does not require the title of a new statute to go into details or to furnish an abstract, synopsis, or index of the contents of the act. Monacelli v. Grimes, supra. The constitutional requirement is satisfied if the title is sufficiently informative so as to put on notice parties interested in the general matter in such a manner as would lead them to inquire into it. In Re Opinion of the Justices, 4 Storey 366, 177 A.2d 205 (1962).
The portion of the title of the narcotics law, quoted above, was sufficiently informative so as to lead interested persons to inquire into the full details of the act. I am of the opinion that the Delaware Narcotics Law satisfies the requirements of Article 2, Section 16 of the State Constitution even before it was reenacted as part of the Delaware Code.
There is still a third reason why the defendant cannot prevail in his attack on the title of the original act. The title includes notice that the term "narcotic drugs" is defined therein. With such notice in the title the legislature is especially free to define the term differently than might be the usual definition of such term. In this act the legislature went on to provide that "`narcotic drugs' means * * * marihuana, marijuana, and all allied drugs of the same botanical family * * *."
Defendant's motion to dismiss the indictment based on the contention that the title of the underlying act is constitutionally deficient is denied.
The next question is whether the indictment advised the defendant of the offense with which he is charged.
Under Criminal Rule 7(c), Del.C. Ann., an indictment must contain a plain, concise written statement of the essential facts constituting the offense charged. The indictment must apprise the defendant with such detail as to enable him to prepare his defense and to plead the proceeding as a bar to a second prosecution for the same offense. Demonia v. State, Del., 210 A.2d 303 (1965).
The defendant argues that the term "marijuana" is so broad that it covers many substances which the legislature did not intend to cover and, therefore, the indictment alleging the sale and possession of marijuana is so indefinite that it fails to |
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] | :00 PM
Indiana Pacers vs. Boston Celtics
Bankers Life Fieldhouse
Indianapolis, IN
Mon Dec 18 201712/18 07:00 PM
Boston Celtics vs. Miami Heat
TD Garden
Boston, MA
Wed Dec 20 201712/20 07:30 PM
New York Knicks vs. Boston Celtics
Madison Square Garden
New York, NY
Thu Dec 21 201712/21 08:00 PM
Boston Celtics vs. Chicago Bulls
TD Garden
Boston, MA
Sat Dec 23 201712/23 07:30 PM
Boston Celtics vs. Washington Wizards
TD Garden
Boston, MA
Mon Dec 25 201712/25 05:30 PM
Charlotte Hornets vs. Boston Celtics
Spectrum Center
Charlotte, NC
Wed Dec 27 201712/27 07:00 PM
Boston Celtics vs. Houston Rockets
TD Garden
Boston, MA
Thu Dec 28 201712/28 08:00 PM
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] | the district court’s denial of his motion for a
new trial pursuant to Rule 33 of the Federal Rules of Criminal Procedure. We are
not persuaded.
We review a district court’s disposition of a motion for new trial for abuse of
discretion. See United States v. Martinez, 763 F.2d 1297, 1312 (11th Cir. 1985).
“On a motion for a new trial based on the weight of the evidence, the court need
not view the evidence in the light most favorable to the verdict. It may weigh the
evidence and consider the credibility of the witnesses.” Id. Motions for a new trial
11
Case: 15-11695 Date Filed: 04/12/2016 Page: 12 of 13
are granted sparingly and only for an exceptional case. See id. A new trial for
example, may be the appropriate remedy when the government’s witnesses have
been severely impeached and the government’s case has been marked by
discrepancies. See id.
This is not an exceptional case, and the weight of the evidence presented did
not warrant granting Mr. Brooks a new trial. The government’s witnesses were not
impeached. The government’s case was circumstantial, but it was not marred by
discrepancies. Mr. Brooks’ competing theory that his son or someone else
repeatedly downloaded the child pornography and refined the files over time was
heard and rejected by the jury. Mr. Brooks’ alternative theory did not present any
discrepancies in the government’s case; it simply presented a different view of the
facts and attempted to shift the blame to someone else. Although it did provide a
counter weight to the evidence put forward by the government, it did provide
enough weight to warrant a reversal of the district court’s denial of a motion for
new trial.
In sum, the district court did not abuse its discretion in denying Mr. Brooks
a new trial. The evidence presented at trial did not preponderate heavily against the
guilty verdicts, such that to let them stand would be a miscarriage of justice. See
Martinez, 763 F.2d at 1313.
12
Case: 15-11695 Date Filed: 04/12/2016 Page: 13 of 13
VI
We affirm Mr. Brooks’ convictions.
AFFIRMED
13
Photos by Jun Cayas “You have so much here. You just have to come together.” - Charlie Co Who would have thought what three days with multiple artists coming from the different parts of the country could bring? It all…Q:
Moq test passes even when verifying both Times.Once() and Times.Never() on same method call
I'm using Xunit to test the Create method on my CarController and I'm using Moq to mock my CarRepository.
I'm then using mockCarRepository.Verify(m => m.Create(It.IsAny<Car>()), Times.Once()); to check that the Create method on my repository is being called. However the test passes irrespective of whether I call it or not.
Here is a complete example where I verify both that Create is called once AND that it is called never. My test passes when I would have expected it to fail.
using System;
using Moq;
using Xunit;
namespace Test
{
public class CarTest
{
[Fact()]
public async void CreateTest()
{
var mockCarRepository = new Mock<CarRepository>();
var carController = new CarController(mockCarRepository.Object);
carController.Create(new Car
{
Make = "Aston Martin",
Model = "DB5"
});
mockCarRepository.Verify(m => m.Create(It.IsAny<Car>()), Times.Once());
mockCarRepository.Verify(m => m.Create(It.IsAny<Car>()), Times.Never());
}
}
public class CarController
{
private readonly CarRepository _repo;
public CarController(CarRepository repo)
{
_repo = repo;
}
public void Create(Car car)
{
_repo.Create(car);
}
}
public class Car
{
public virtual String Make { get; set; }
public virtual String Model { get; set; }
}
public class CarRepository
{
public virtual void Create(Car car)
{
// DO SOMETHING
}
}
}
When I debug the test, although it still passes, I notice that the following exception is thrown:
A first chance exception of type 'Moq.MockException' occurred in Moq.dll
Additional information:
Expected invocation on the mock should never have been performed, but was 1 times: m => m.Create(It.IsAny<Car>())
No setups configured.
Performed invocations:
CarRepository.Create(Test.Car)
The exception is expected as I am calling Create once and verifying Times.Never() but I would like my test to fail. What do I need to do to achieve this?
Update It turns out that the problem was that I'd marked my test as async - removing that causes it to pass. However the actual code I'm writing will call an async method, so my question is now, how can I verify methods are called when using asynchronous methods?
A:
See the answer here for an explanation of why async void test methods do not work in xUnit.
The solution is to give your test method an async Task signature.
async void functionality has been added ready for version 2.0 of xunit, see here for details.
The series: We look at manufacturing companies that are using technology to create “smart factories” fit for long-term global competitiveness.
Open this photo in gallery Parmalat Canada has retooled its factories to bottle milk in new, recyclable,1.5-litre bottles made of polyethylene terephthalate (PET). They keep milk fresher for a longer period of time. Handout/Lactancia
Regular, unadorned milk remains a staple, and that’s part of a problem.
“Don’t mess with my milk, don’t change it,” said Marco De Palma, lamenting the typical consumer perception in Canada.
Story continues below advertisement
Canadians tend to see milk as fresh, unchanged, sacrosanct, but then they look for other beverages when they get bored with it. So, as general manager of fluid milk and distributor sales at Parmalat’s office in Toronto, Mr. De Palma wants to – in fact needs to – make milk more exciting, as does the rest of the industry.
Innovation means bringing in new manufacturing methods, new milk flavours, new formulas into a sector that’s aging and somewhat stuck in the past. Made all the more difficult by a product that spoils so quickly.
But innovation is happening, because it has to, industry watchers say. Overall milk consumption continues to decline. Almond and soy drinks continue to siphon off customers. The usual link between milk consumption and demographics – that is, when the population rises, overall milk consumption typically rises – has weakened, some note. Many new Canadians may more readily reach for a glass of yogurt-based lassi or a salty, yogurty ayran. And among those consumers buying milk regularly, alternatives such as lactose-free milk are stealing away customers, in this age of growing dietary intolerance.
“There is a mix of what people are buying, but overall consumption is still in decline,” Mr. De Palma said.
To stem this drop, Parmalat Canada, a subsidiary of Parmalat SpA of Italy, has launched a new plastic bottle for its Lactania PurFiltre brand. This may hardly seem revolutionary, but for Parmalat, it’s a step within a larger strategy.
The bottles' size (1.5 litres) is out of the norm, different than regular one- or two-litre cartons, or bags and common milk jugs. They’re made of polyethylene terephthalate (PET) rather than the usual high density polyethylene (HDPE) for plastic jugs, with a bottle shape designed to make it look unlike other milk bottles on the dairy shelf.
This, of course, entailed equipping plants with new machinery and production methods, including equipment that can handle other kinds of milk processing, which can give the milk a longer shelf life. Parmalat hopes that the new-look, PET bottles, which are recyclable and BPA free, are a step in keeping milk fresher, longer, broadening its reach into new markets.
Story continues below advertisement
“Those bottles will have 60 days of shelf life after production, compared to a carton which hovers between 39 to 50 days, depending on the product. That shelf life gives us two things: one, the ability to launch innovation and sell it from coast to coast as much as we can; and two, to introduce new categories of milk in provinces that currently don’t have them,” |
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] | Biography Channel, NBC and more. He also wrote and directed two sold-out 2014 BroadwayWorld charity concert events featuring all-star casts, EVERYTHING'S COMING UP BROADWAYWORLD.COM: A JULE STYNE TRIBUTE and THE LORD & THE MASTER: BROADWAYWORLD.COM SINGS THE MUSIC OF ANDREW LLOYD WEBBER & STEPHEN SONDHEIM.namespace CruiseControl.Common
{
using System.Runtime.Serialization;
/// <summary>
/// The arguments for a query.
/// </summary>
[DataContract]
public class QueryArguments
{
#region Constructors
/// <summary>
/// Initializes a new instance of the <see cref="QueryArguments"/> class.
/// </summary>
public QueryArguments()
{
this.DataToInclude = DataDefinitions.Both;
}
#endregion
#region Public properties
#region FilterPattern
/// <summary>
/// Gets or sets a REGEX pattern for filtering the actions.
/// </summary>
/// <value>
/// The filter pattern.
/// </value>
[DataMember]
public string FilterPattern { get; set; }
#endregion
#region DataToInclude
/// <summary>
/// Gets or sets the data to include.
/// </summary>
/// <value>
/// The data to include.
/// </value>
[DataMember]
public DataDefinitions DataToInclude { get; set; }
#endregion
#endregion
}
}Q:
How can I pass data from another class to a GUI?
How do I pass data/values from one class to another using GUI? I'm trying to pass the message2 array to namesOut label in GUI. I'm stuck and getting an error.
Here's my code:
GUI
package testClassesGUI;
import java.awt.BorderLayout;
public class UI extends JFrame {
private JPanel contentPane;
/**
* Launch the application.
*/
public static void main(String[] args) {
EventQueue.invokeLater(new Runnable() {
public void run() {
try {
UI frame = new UI();
frame.setVisible(true);
} catch (Exception e) {
e.printStackTrace();
}
}
});
}
/**
* Create the frame.
*/
public UI() {
setDefaultCloseOperation(JFrame.EXIT_ON_CLOSE);
setBounds(100, 100, 450, 300);
contentPane = new JPanel();
contentPane.setBorder(new EmptyBorder(5, 5, 5, 5));
setContentPane(contentPane);
contentPane.setLayout(null);
JLabel lblDisplayOutNames = new JLabel("Display out names:");
lblDisplayOutNames.setBounds(32, 25, 121, 16);
contentPane.add(lblDisplayOutNames);
JLabel namesOut = new JLabel(""); //here i need to bring the data
namesOut.setBounds(32, 63, 228, 87);
contentPane.add(namesOut);
}
}
Logic:
Here I'm getting an error.
package testClassesGUI;
public class Logic {
private String[] someArray = { "Great", "World" };
// getter method
public String[] message2(){
return someArray;
}
// setter method
public void setSomeArray(String[] someArray){
this.someArray = someArray;
}
UI logicObject = new UI();
logicObject.namesOut.setText(message2); //here my error misplaced construct(s), variable declaratoridexpected
}
Your help is much appreciated.
A:
Put this in your UI constructor. You should create a Logic object in it
public UI() {
setDefaultCloseOperation(JFrame.EXIT_ON_CLOSE);
setBounds(100, 100, 450, 300);
contentPane = new JPanel();
contentPane.setBorder(new EmptyBorder(5, 5, 5, 5));
setContentPane(contentPane);
contentPane.setLayout(null);
JLabel lblDisplayOutNames = new JLabel("Display out names:");
lblDisplayOutNames.setBounds(32, 25, 121, 16);
contentPane.add(lblDisplayOutNames);
JLabel namesOut = new JLabel(""); //here i need to bring the data
namesOut.setBounds(32, 63, 228, 87);
contentPane.add(namesOut);
Logic logic = new Logic(); <<---
String[] array = logic.message2(); |
|
String s = ""; |
for (String str : array){ |
s += str + " "; |
} |
|
namesOut.setText(s); <<----
}
You can delete this from your Logic class
UI logicObject = new UI();
logicObject.namesOut.setText(message2);
International NGOs are instruments of cultural imperialism
RIO DE JANEIRO, Brazil – In developing or underdeveloped countries (in Latin America, Africa, Asia and parts of Eastern Europe), the participation of NGOs in the provision of basic public services is increasing. They aim to replace weak and/or poor states in various resource-poor sectors. Some of these NGOs are also involved in state oversight, supposedly in favor of “human rights.”
It is easy to point out fundamental problems in these NGOs. States are accountable to their citizens. If their governments fail to live up to the expectations of the masses, they risk being traded or, in more drastic cases, even toppled by an angry population.
Who do NGOs respond to? Just to your donors, usually wealthy citizens, foreign governments or powerful corporations. These NGOs pass on to their donors information (true or otherwise) on the beneficiaries to the donors, who then guarantee the donations. But understand: if NGOs succeed in solving the problems they care about, they simply will not be needed anymore. However, it is clear that NGOs will not disappear, and that they do not exist to solve definitively the problems of their interest.
The phenomenon of NGOs has exploded since the 1980s, being born in the rich countries of the first world, for very clear reasons. In the global capitalist elite there are distinct degrees of intelligence and sensitivity, and among them a more perceptive layer noted that the implementation of neoliberalism was polarizing societies and generating strong social commotion. Neoliberal politicians, entrepreneurs, and bankers then began to finance and promote a “bottom-up” parallel strategy, with organizations driven by an “anti-statist” ideology whose aim was to appease the masses and at the same time , to promote the dismantling of the state and to demobilize serious political and social organizations.
In the 1990s, these NGOs were already thousands and moving around $ 4 billion worldwide every year. One of its main sources of funding has been the World Bank. The point of convergence between interests is clear: NGOs criticize the state from a progressive left-wing perspective, in defense of a supposed civil society, while the right wing does it in defense of the market. In other words, as neo-liberal regimes devastated their own countries and foreign countries, flooding them with cheap imports, crushing them with usurious debts, abolishing labor laws and creating a growing mass of precarious workers, NGOs assumed the role of “self-help” to local communities, deviating from any kind of radical political and social militancy.
NGOs, in this sense, are nothing more than a “communal” face of neoliberalism. They are financed by the same characters that cause the problems they are aiming to fight. In this sense, they play a fundamentally depoliticizing and relieving role. Its aim is not to solve problems, but to try to stifle conflicts and make capitalist exploitation more palatable.
In this way, the very classification they lead is even fallacious. Considering that they receive funding from capitalist governments, and that they usually work with agencies and departments of these governments, it is not true that these institutions are effectively non-governmental. More recently, NGOs have taken an even more prominent role in the imperialist strategies of the globalist elite. “Human rights” NGOs infest countries considered enemies by the Atlantean governments. There, these NGOs work to undermine the institutional solidity of the enemy countries’ system, instilling “civil society” against their rulers in the name of “human rights,” but for the benefit of the Atlantean governments and international corporations. So it was with the Arab Spring or with the Maidan.
NGOs affiliated with George Soros and other financiers and / or funded by the US Department of State have implemented the manuals of |
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] | one on one.
Romney and Obama have one more debate, on Monday at Lynn University in Boca Raton, Fla. Although the focus of the final forum is foreign policy, it will be a time for the candidates to make their closing arguments to try to woo undecided voters and motivate their respective bases, whose enthusiasm becomes crucial in a close contest.
But after what happened at Hofstra, it’s clear that the real competition will be the fight to the finish, a battle for the battleground states where the election will be decided. The most important are Virginia, Florida and Ohio — with Ohio being perhaps first among equals. After that come Iowa, Colorado and New Hampshire, Nevada, North Carolina and Wisconsin.
Few events have changed the race as quickly or dramatically as the first debate. Romney’s clear victory over Obama in Denver turned around the campaign narrative, which was heading toward a premature conclusion that the contest was virtually over. It also shifted polls, both nationally and in the battleground states.
How many minds will be changed by what happened on Tuesday night? There is likely to be a boost in enthusiasm among Obama loyalists, and that’s not insignificant. Given that some parts of his coalition, young voters in particular, are not as motivated as they were four years ago, that jolt of energy could be important. Obama advisers know that turning out their voters will be harder for them than it will be for Romney’s team.
But Romney’s initial performance did much to generate enthusiasm among his supporters. That’s not likely to be diminished by Tuesday’s debate. After Denver, Republicans began to think it was possible to win. Their enthusiasm going forward is unlikely to slacken. The turnout battle from now until Election Day will be as fiercely fought as was the battle at Hofstra.
One of the keys to the outcome will be women, and a big question from Tuesday’s debate is how women will react to what they saw. Romney appeared to be making progress in reducing Obama’s big margins among female voters in the past two weeks. But he may have hurt himself.
Just as Vice President Biden’s smiles and laughs during his debate with GOP vice presidential nominee Paul Ryan (Wis.) last week turned off some voters, Romney’s efforts to push back against CNN’s Candy Crowley, who served as moderator, could alienate some women.
Heading into the second debate, there was little disagreement that a race that had seemed to be slipping away from Romney in September was back to what strategists in both parties had predicted would be a competitive contest to the end.
In the hours before the exchange, the Romney and Obama campaigns offered genuinely conflicting and perhaps self-serving assessments of how things stood — in the battlegrounds and among key demographic groups.
Take the state of play in Ohio. Before Denver, Obama had a clear and, in some polls, big lead. In a pre-debate appearance Tuesday in the spin room, Sen. Rob Portman (R-Ohio) told reporters that the race there was even. “Our own tracking indicates it’s a dead heat,” he said.
Portman, who has played the president in Romney’s debate preparations, said that before Denver, the challenger was behind by “a big gap,” but added that Romney has made steady progress since then. “Frankly, it wasn’t just a bump after the debate.”
Jim Messina, Obama’s campaign manager, offered a counterview. He said the first debate may have tightened the race, but added that the contest always was destined to close in the final month. He also said that Obama was still strong in the Midwest — Ohio, Iowa and Wisconsin.
“We continue to have more pathways to 270 votes than Romney,” he said. “All of our pathways are still there. We are where we need to be.”
What voters saw Tuesday night was just how big the choice will be in November. Romney and Obama painted dire pictures of what will happen if the other is elected in three weeks. Voters may have heard this before, but it was more sharply etched, with the candidates standing only a few feet apart, than in the television commercials or campaign appearances.
Now the campaign turns to fundamentals — one more debate and then a sprint to Nov. 6. The race has been long and hard-fought, but Obama and Romney showed Tuesday night that they have plenty left for the final stretch, and their teams are ready for what comes next.s v prime?
True
Let w(t) = 6 - t**2 - 3 + 0 - 6*t. Let o be w(-6). Suppose o*b - b - 70 = 0. Is b prime?
False
Suppose -5999 + 2486 = -3*n. Is n prime?
True
Suppose -3*z + 13 = -8. Suppose -8 = -3*s + z. Suppose 2*n + s*v - 305 = 0, -3*n - 2*v + 151 = -2*n. Is n a composite number?
True
Suppose 0 = 33*i - 28*i - 2045. Is i composite?
False
Is 807/9 + 4/(-6) prime?
True
Let u(p) = p - 10. Let q be u(8). Is q/8 + (-269)/(-4) composite?
False
Is ((-2)/(-6))/((-23)/(-66171)) a composite number?
True
Let y be (-15)/(-6)*8/10. Suppose 335 = -g + y*g. Suppose -d + 6*d - g = 0. Is d a prime number?
True
Suppose -3*z = -5*y - 64, -12 = -2*z + z - 3*y. Let u = z - -1. Is u prime?
True
Suppose -4*r + 20 = 4. Is r prime?
False
Let c = 8 + -4. Suppose c = -4*q - 0*q. Is 0 + 6*4 + q prime?
True
Suppose 5*z - 33 + 13 = 0, z - 3 = d. Is 2*d/(-5)*-145 composite?
True
Let d(x) = 3*x**3 - 2*x**3 + 0*x - 5*x + 0*x + 4*x**2 + 2. Let z be d(3). Let y = -28 + z. Is y a composite number?
True
Let f = -219 + 364. Is f prime?
False
Let j(d) = -d**3 + 7*d**2 + 10*d - 1. Let r be j(8). Is 522/r + 1/5 a composite number?
True
Suppose -d = -a - 4*a + 23, -d - 5*a = -27. Suppose -530 = -d*i - 0*i. Suppose 0 = -4*h + i - 81. Is h composite?
True
Let r(f) = f**2 - 6*f. Let g be r(6). Let h(t) = t + 4. Let y be h(g). Is 1/y - 210/(-24) prime?
False
Is (-1 - 0)/((-2)/(-53384)*-4) composite?
False
Let c(v) = 9*v**2 - 5*v + 1. Is c(-5) composite?
False
Suppose -7*n + 2*n + 10 = 0. Suppose -n*o + 6 = -0*o. Suppose 0*a + 609 = o*a. Is a prime?
False
Let z(b) = 14*b**2 + b + 1. Is z(-2) composite?
True
Let o = 6 - 2. Is 9177/49 + o/(-14) a prime number?
False
Let v = 244 - 165. Is v composite?
False
Let q = -9 + 14. Suppose 4 = i - m, 5*i - 16 = m - 0. Suppose -267 = -3*r + i*n, -r + q*n = -3*r + 150. Is r composite?
True
Suppose 0 = -4*t - 5*g - 11 + 34, -3 = -3*t + g. Suppose 0 + t = s. Is ((-33)/s)/((-3)/4) composite?
True
Suppose 2*o - m = 9, -3*o + 7*o - 3*m = 19. Suppose -o*r - 68 + 304 = 0. Is r a prime number?
True
Let j be (3 - -15) + (-4)/2. Let w = j + -11. Suppose 147 + 8 = w*z. Is z prime?
True
Let a = 717 + -304. Is a composite?
True
Suppose 0 = -12*g + 16*g - 2140. Is g prime?
False
Let j be 3/(-5) - (-39)/15. Suppose -p - j*i = p - 114, 6 = -3*i. Is p composite?
False
Let q = -4 - -4. Suppose -4*k + k + 45 = q. Is k composite?
True
Suppose 4*h + l - 395 = 3*h, 0 = -4*h + 4*l + 1548. Is h a prime number?
False
Let y(d) = -d |
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] | beijn-K\u00f6\u00df" },
{ "CK", "de Kuuk-Enselle" },
{ "CL", "Schiile" },
{ "CM", "Kammeruhn" },
{ "CN", "Schiina" },
{ "CO", "Kolumbije" },
{ "CP", "de Klipperton-Ensel" },
{ "CR", "Kostarika" },
{ "CU", "Kuba" },
{ "CV", "de kapv\u00e4rdesche Enselle" },
{ "CW", "Cura\u00e7ao" },
{ "CX", "de Weihnaachs-Ensel" },
{ "CY", "Z\u00fcppere" },
{ "CZ", "de Tsch\u00e4schei" },
{ "DE", "Do\u00fctschland" },
{ "DG", "de Diego-Garcia-Ensel" },
{ "DJ", "Dschibutti" },
{ "DK", "D\u00e4nemark" },
{ "DM", "Dominnika" },
{ "DO", "de Dommenekaanesche Reppublik" },
{ "DZ", "Alljeerije" },
{ "EA", "Ze\u2019uta un Meliija" },
{ "EC", "\u00c4kwador" },
{ "EE", "\u00c4\u00dfland" },
{ "EG", "\u00c4j\u00fcpte" },
{ "EH", "W\u00e4\u00df-Sahara" },
{ "ER", "\u00c4ritreja" },
{ "ES", "Schpaanije" },
{ "ET", "\u00c4ttijoopije" },
{ "EU", "de Europ\u00e4jesche Unijon" },
{ "FI", "Finnland" },
{ "FJ", "de Fidschi-Endelle" },
{ "FK", "de Falkland-Enselle" },
{ "FM", "Mikroneesije" },
{ "FO", "de F\u00e4rr\u00f6r-Enselle" },
{ "FR", "Frankrisch" },
{ "GA", "Jabuhn" },
{ "GB", "Jruu\u00dfbrettannije" },
{ "GD", "Jrenaada" },
{ "GE", "Jeorrjije" },
{ "GF", "Franz\u00fc\u00fcsesch Jujaana" },
{ "GG", "J\u00f6\u00f6nsei" },
{ "GH", "Jaana" },
{ "GI", "Jibralltaa" },
{ "GL", "Jr\u00f6hnland" },
{ "GM", "Jambija" },
{ "GN", "Jinneha" },
{ "GP", "Juadelupp" },
{ "GQ", "\u00c4quatorial Jineeja" },
{ "GR", "Jriescheland" },
{ "GS", "S\u00f6d-Jeorjie un de s\u00f6dlijje Botteramms-Enselle" },
{ "GT", "Juwatemaala" },
{ "GU", "Juham" },
{ "GW", "Jinneha_Bi\u00dfau" },
{ "GY", "Jujaana" },
{ "HK", "Hongkong" },
{ "HM", "de Heart Ensel un de McDonald-Enselle" },
{ "HN", "Honduras" },
{ "HR", "Krowazije" },
{ "HT", "Ha\u2019itti" },
{ "HU", "Unjann" },
{ "IC", "de Kannaresche Enselle" },
{ "ID", "Indoneesije" },
{ "IE", "Irrland" },
{ "IL", "I\u00dfra\u00e4l" },
{ "IM", "de Ensel M\u00e4n" },
{ "IN", "Indije" },
{ "IO", "Brettesche Besezunge em indesche Oozejahn" },
{ "IQ", "Irak" },
{ "IR", "Persije" },
{ "IS", "I\u00dfland" },
{ "IT", "Itaalije" },
{ "JE", "J\u00f6\u00f6seh" },
{ "JM", "Jammaika" },
{ "JO", "Jordaanije" },
{ "JP", "Japan" },
{ "KE", "Keenija" },
{ "KG", "Kirrjiisije" },
{ "KH", "Kambodscha" },
{ "KI", "Kiribati" },
{ "KM", "de Kommoore" },
{ "KN", "Zint Kitts un Nevis" },
{ "KP", "Nood-Koreja" },
{ "KR", "S\u00f6d-Koreja" },
{ "KW", "Kuweit" },
{ "KY", "de Kaiman-Enselle" },
{ "KZ", "Kassakstahn" },
{ "LA", "La\u2019os" },
{ "LB", "Lebbannon" },
{ "LC", "de Ensel Zint-Lutscha" },
{ "LI", "Lischteschtein" },
{ "LK", "Sri Lanka" },
{ "LR", "Libeerija" },
{ "LS", "Lesooto" },
{ "LT", "Littaue" },
{ "LU", "Luxembursch" },
{ "LV", "L\u00e4tland" },
{ "LY", "Libbije" },
{ "MA", "Marokko" },
{ "MC", "Monakko" },
{ "MD", "Moldaavije" },
{ "ME", "et Monteneejro" },
{ "MF", "de Zint-M\u00e4\u00e4tes-Ensel" },
{ "MG", "Maddajaska" },
{ "MH", "de Machschall-Enselle" },
{ "MK", "Mazedoonije" },
{ "ML", "Maali" },
{ "MM", "Birma" },
{ "MN", "Mongjolei" },
{ "MO", "Makau" },
{ "MP", "de n\u00f6\u00f6dlijje Marijanne-Enselle" },
{ "MQ", "Machtinik" },
{ "MR", "Mautitaanije" },
{ "MS", "Mong\u00dferrat" },
{ "MT", "Malta" },
{ "MU", "Maurizijus" },
{ "MV", "Mallediive" },
{ "MW", "Malawi" },
{ "MX", "M\u00e4xiko" },
{ "MY", "Malaisije" },
{ "MZ", "Mosambik" },
{ "NA", "Namiibije" },
{ "NC", "Neuschottland" },
{ "NE", "Nijer" },
{ "NF", "de Noofok-Ensel" },
{ "NG", "Nikaraagua" },
{ "NI", "Nikaraaguwa" },
{ "NL", "de Nederl\u00e4ng" },
{ "NO", "Norrweeje" },
{ "NP", "Nepall" },
{ "NR", "Nauru" },
{ "NU", "Niue" },
{ "NZ", "Neuseeland" },
{ "OM", "Oman" },
{ "PA", "Pannama" },
|
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263
] | Isolated trans-acting loci that affect the expression of one or a few genes appear to be uncommon.
Locations of eQTLs in the genome.
(A) Map of local and distant eQTLs. The genomic locations of eQTL peaks (x-axis) are plotted against the genomic locations of the genes whose expression they influence (y-axis). The strong diagonal band corresponds to local eQTLs. The many vertical bands correspond to eQTL hotspots. Point size is scaled as a function of eQTL effect size, measured in fraction of phenotypic variance explained. (B) The number of gene expression traits linking to each of 102 identified eQTL hotspots (Methods) are shown as vertical bars. Text labels identify genes in hotspots referred to in the text.
The 102 hotspots affected a median of 425 genes, ranging from 26 (a newly discovered hotspot at position 166,390 bp on chromosome III) to 4594 at the previously reported MKT1 hotspot (Zhu et al., 2008) (82% of 5629 genes with any signal at a hotspot; Figure 3B). Three additional hotspots each affected more than half of all genes. They include a previously described hotspot at the HAP1 gene (Brem et al., 2002) (3640 genes affected), as well as two newly detected hotspots on chromosome XIV. A hotspot at 372,376 bp affected 4172 genes and is likely caused by a variant that recently arose in the KRE33 gene in the RM parent used in our cross (Jerison et al., 2017). A hotspot at position 267,161 bp affected 3169 genes and spans the genes GCR2, YNL198C, WHI3 and SLZ1. These results indicate that hotspots can have extraordinarily wide-reaching effects on the transcriptome, with some influencing the expression of the majority of all genes.
Widespread effects caused by single loci likely arise from a cascade of effects in which strong primary effects spread through the cellular regulatory network. For example, the BY allele of the transcriptional activator HAP1 carries a transposon insertion that reduces HAP1 function. As expected, the BY allele strongly reduced the expression of known transcriptional targets of HAP1: 26 out of the 69 HAP1 targets present in our data were among the 50 genes with the largest reduction in expression in segregants carrying the BY allele of HAP1 (p<2.2e-16, odds ratio = 138). In total, only 75 direct transcriptional HAP1 targets are known. Unless previous work missed thousands of HAP1 targets, the vast majority of the 3640 trans eQTLs at HAP1 must reflect indirect, secondary consequences of the direct transcriptional effects. HAP1 is an activator of genes involved in cellular respiration. Thus, the many secondary effects of the BY HAP1 allele on gene expression may be mediated by cellular responses to altered metabolism arising from reduced respiration.
Our Supplementary Files and Datasets provide detailed information about each hotspot. Source data 8 contains a table that gives an overview of the hotspots, including their location, genes affected (details in Source data 9), and analyses of function (details in Source data 10) and transcriptional regulation (details in Source data 11) of the target genes of each hotspot. Supplementary file 5 visually represents each hotspot region, and Supplementary file 6 displays gene networks formed by the strongest target genes of each hotspot.
Causal genes underlying hotspots
Functional analysis of eQTL hotspots requires identification of the underlying causal genes, which has been challenging to do systematically. We developed a multivariate fine-mapping algorithm that narrows hotspot positions by leveraging information across the genes that map to each hotspot (Materials and methods). Briefly, we used all genes with an eQTL on a given chromosome and regressed out genetic factors on all other chromosomes and additional non-genetic factors. We reduced the dimensionality of the residual expression levels by singular value decomposition to capture linear combinations of traits that account for most of the variance in residual expression. We scanned the given chromosome for genetic influences on the multivariate distribution of these linear combinations, while controlling FDR via permutations. Finally, we used bootstraps to compute confidence intervals for hotspot locations (Figure 4 and 5).
Genes located in hotspot regions.
(A) Histogram showing the number of genes located in the hotspot regions. (B) A hotspot on chromosome VIII maps to the gene STB5. From top to bottom: the general region on the chromosome, the empirical frequency distribution of hotspot peak locations from 1000 bootstrap samples (Materials and methods), locations of BY/RM sequence variants (red: variants with ‘high’ impact such as premature stop codons (McLaren et al., 2016); orange: ‘moderate’ impact such as nonsynonymous variants; grey: ‘low’ impact such as synonymous or intergenic variants), and gene locations. The light blue area shows the 95% confidence interval of the hotspot location as determined from the bootstraps. The red line shows the position of the most frequent bootstrap marker. (C) Genes for which the BY allele at the STB5 hotspot is linked to lower expression are enriched for STB5 transcription factor (TF) binding sites in their promoter regions. The figure shows enrichment results for all annotated TFs (grey dots), with the strength of enrichment (odds ratio) on the x-axis vs. significance of the enrichment on the y-axis. The STB5 result is highlighted in red.
With this approach, we resolved the locations of 26 hotspots to regions containing three or fewer genes (a total of 58 genes; Figure 4A). Three hotspots contained exactly one gene (GIS1, STB5, and MOT3). We previously identified and experimentally confirmed the causal genes at several major hotspots (MKT1 (Zhu et al., 2008), HAP1 (Brem et al., 2002), IRA2 (Smith and Kruglyak, 2008), GPA1 (Yvert et al., 2003), and the mating-type locus [Brem et al., 2002]). These were all correctly localized by the algorithm, validating this fine-mapping strategy.
The 58 genes at 26 high-resolution hotspots are highly enriched for the causal genes underlying the hotspots, making it possible to systematically study the functions of hotspot regulators. These genes were less likely to be essential or to have a human homolog than other yeast genes but did not differ from other genes in their expression level or the number of physical or genetic interaction partners (Supplementary file 7). The hotspot genes had highly significant enrichments for gene ontology (GO) terms related to transcriptional regulation (e.g. GO:0006357 ‘regulation of transcription from RNA polymerase II promoter’: 19 genes among the 58; 4 expected; p=4e-9; Figure 4—figure supplement 1; Source data 12), as well as weaker enrichments for terms related to response to nutrient levels (GO:0031669; ‘cellular response to nutrient levels’: 8 genes, 1 expected, p=6e-6)
These analyses indicate that causal hotspot genes are disproportionately involved in transcriptional regulation, a signal that was not picked up in an earlier study with fewer, less-well-resolved hotspots (Yvert et al., 2003). For example, we fine-mapped a new hotspot that affected 382 genes to a single gene, the transcription factor STB5 (Figure 4B). STB5 is a transcriptional activator of multidrug resistance genes (Kasten and Stillman, 1997). A previous analysis suggested reduced activity of the STB5 BY allele compared to the RM allele (Lee and Bussemaker, 2010). Consistent with this observation, we found that the promoters of genes whose expression was lower in the presence of the STB5 BY allele were strongly enriched for STB5 binding sites (Figure 4C).
To further examine the role of sequence variation in transcription factor genes, we focused on transcription factors with variants predicted to be damaging to protein function such as premature stop codons or frameshifts. There are eight such genes in our data. Remarkably, six of these (GAT1, HMS1, PUT3, RFX1, SRD1, TBS1) were located in a hotspot, often very close to the estimated peak location (Figure 4—figure supplement 2). None of these expression hotspots have been reported previously, although variation at GAT1 has been reported to influence traits relevant for wine production (Salinas et al., 2012), and a premature stop codon in the RM allele of RFX1 has been linked to reduced activity of this transcriptional repressor (Lee and Bussemaker, 2010). The remaining two transcription factors with predicted damaging mutations did not overlap a hotspot. Of these, a predicted frameshift in YRM1 is very close to the end of the coding region, while a predicted frameshift in STB4 appears to be an annotation artifact: it resides in a region that is annotated as coding but that does not in fact appear to be transcribed (Figure 4—figure supplement 3, [Albert et al., 2014a]).
Hotspot genes can also influence mRNA levels more indirectly – for instance, by shaping the cellular response to external stimuli such as nutrient availability. For example, we fine-mapped a hotspot, which influenced 645 genes, to an interval on chromosome VIII containing six genes (Figure 4—figure supplement 4A). One of these is ERC1, which encodes a transmembrane transporter. BY but not RM carries a frameshift in this gene, which removes the last two out of 12 predicted transmembrane helices of the protein (Fehrmann et al., 2013). This variant is known to reduce cell-to-cell variability (or |
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] | Ebersberg, Germany) with the following sequence: *MAP-LC3b*: 5′- CGT CCT GGA CAA GAC CA-3′ (forward), 5′-CCA TTC ACC AGG AGG AA-3′ (reverse); *SQSTM1/p62:* 5′-AGG GAA CAC AGC AAG CT-3′ (forward), 5′-GCC AAA GTG TCC ATG TTT CA-3′ (reverse); *GAPDH*: 5′-CCA GAA CAT CAT CCC TGC AT-3′ (forward), 5′-CAG TGA GCT TCC CGT TCA-3′ (reverse). The evaluated efficiency of each set of primers was close to 100% for both target and reference genes. Real-time PCR was performed using the CFX 96 Real-Time System (Bio-Rad, Hercules, CA, USA) in a 10 µl total volume, using the iTaq SYBR Green Supermix (Bio-Rad), and with 500 n[m]{.smallcaps} primers. PCR cycling conditions were as follows: 94°C for 10 min, 40 cycles at 94°C for 15 s and 60°C for 1 min. Melting curve analysis was performed at the end of each PCR assay as a control for specificity. Data were expressed as *C*~t~ values and used for the relative quantification of targets with the ΔΔ*C*~t~ calculation. To exclude potential bias due to averaging data transformed through the equation $2^{- \Delta\Delta C_{t}}$ to give *N*-fold changes in gene expression, all statistics were performed with Δ*C*~t~ values. Each experiment was carried out with four independent samples.
Western blot (WB) analysis and FRA {#s4d}
----------------------------------
NSC34 cells were plated in 12-well multiwell plates at 80 000 cell/ml, transfected as previously described. For dose-dependent analysis, the cells were treated with 10 n[m]{.smallcaps}/100 n[m]{.smallcaps}/1 µ[m]{.smallcaps} Bicalutamide or 10 m[m]{.smallcaps}/100 m[m]{.smallcaps}/1 M trehalose. In the other experiments, the cells were treated with 100 m[m]{.smallcaps} trehalose and/or 100 n[m]{.smallcaps} Bicalutamide and/or 10 n[m]{.smallcaps} testosterone for 48 h. In experiments involving autophagy blockage, 10 m[m]{.smallcaps} 3-MA was added to the cells for the last 48 h. In experiments where proteasome was inhibited, the cells were treated with 10 µ[m]{.smallcaps} MG132 for the last 16 h (overnight treatment).
After 48 h, cells were harvested and centrifuged 5 min at 100 *g* at 4°C; the cell pellets were re-suspended in PBS (added of the protease inhibitors cocktail, Sigma-Aldrich) and homogenized using slight sonication as previously described ([@DDU419C63]). Total proteins were determined with the bicinchoninic acid method (BCA assay, Euroclone).
PC12/AR.Q112 cells were plated in six-well multiwell plates at 80 000 cell/ml, induced with 1 μg/ml of doxycycline and treated with 100 m[m]{.smallcaps} trehalose and/or 100 n[m]{.smallcaps} Bicalutamide and/or 10 n[m]{.smallcaps} testosterone for 48 h. After 48 h, cells were harvested and centrifuged 5 min at 100 *g* at 4°C; the cell pellets were re-suspended in RIPA buffer (added of the protease inhibitors cocktail, Sigma-Aldrich) and homogenized using slight sonication. The samples were centrifuged 15 min at 15 000 *g* at 4°C. The soluble fraction (supernatant) was separated from the insoluble one and the protein concentration was determined by the BCA assay. The pellet fraction was re-suspended in 20 μl of 4x sample buffer, and a relative amount was loaded into the gel, according to the protein assay on the soluble fraction.
WB was performed on 15% SDS--polyacrylamide gel electrophoresis loading 10--15 µg of total proteins. Samples were then electrotransferred to PVDF (polyscreen transfer membrane, PerkinElmer, Waltham, MA, USA) using a semi-dry transfer apparatus (Trans-Blot^®^ Turbo™ Transfer System, Bio-Rad). The membranes were treated with a blocking solution containing 5% nonfat dried milk powder (EuroClone, MI, Italy) in Tris buffered saline with Tween for 1 h and then incubated with the following primary antibodies: (a) rabbit polyclonal AR-H280 (dilution 1 : 3000) to detect wt AR and ARpolyQ; (b) rabbit polyclonal anti-LC3 (dilution 1:4000) to detect LC3; (c) rabbit polyclonal anti-SQSTM1/p62 (dilution 1:4000) to detect SQSTM1/p62; (d) mouse monoclonal anti-α-tubulin (Sigma-Aldrich, dilution 1:4000) to detect total α-tubulin. Immunoreactivity was detected using the following secondary peroxidase-conjugated antibodies: goat anti-rabbit (Santa Cruz, dilution 1:20 000) was used to identify the anti-AR, the anti-LC3 and the anti-SQSTM1/p62 antibodies; goat anti-mouse (sc-2005, Santa Cruz, dilution 1:20 000) was used to identify the anti-α-tubulin antibody. The immunoreactive regions were then visualized using the enhanced chemiluminescence detection kit reagents (ECL prime Western Blotting Substrate, GE Healthcare, Maidstone, UK). The same membranes were subsequently processed with different antibodies to detect the levels of different proteins in the same sample loaded on the gel, after stripping for 10 min at room temperature (StripABlot, EuroClone).
FRA was performed by sample filtration through a 0.2 µm cellulose acetate membrane (Whatman, GE Healthcare) using a Bio-Dot SF Microfiltration Apparatus (Bio-Rad) and loading 9 µg (NSC34 cells) of the total proteins or 1.5 µg (PC12) of the supernatant fraction. Slot-blots were probed as described for WB to detect AR.Q46 or AR.Q112.
A ChemiDoc XRS System (Bio-Rad) was used for the image acquisition of WB and FRA. Optical intensity of samples assayed with WB or FRA was detected and analyzed using the Image Lab software (Bio-Rad).
Fluorescence, IF and microscopy on NSC34 cells {#s4e}
----------------------------------------------
NSC34 cells were plated in 12-well multiwell plates containing coverslips at 70 000 cells/well density, transiently transfected with the plasmid coding for GFP-ARQ48 as previously described and treated with 100 m[m]{.smallcaps} trehalose and/or 100 n[m]{.smallcaps} Bicalutamide and/or 10 n[m]{.smallcaps} testosterone for 48 h. The cells were then fixed and processed as previously described (Sau, 2007). To analyze LC3 and SQSTM1/p62 protein expressions, we used the following primary antibodies: rabbit polyclonal anti-LC3-B antibody 1 : 1000 (Sigma-Aldrich) in 5% nonfat milk, rabbit polyclonal anti-SQSTM1/p62 antibody 1 : 1000 (Abcam, Cambridge, UK) in 5% nonfat milk. Secondary antibodies used were: Alexa 488 anti-rabbit and Alexa 594 anti-rabbit (Life Technologies) 1 : 1000 in milk. Cells were stained with DAPI to visualize the nuclei. An Axiovert 200 microscope (Zeiss Instr., Oberkochen, Germany) equipped with FITC/TRITC/DAPI and combined with a Photometric Cool-Snap CCD camera (Ropper Scientific, Trenton, NJ, USA) was used. Images were processed using the Metamorph software (Universal Imaging, Downingtown, PA, USA).
Statistical analysis {#s4f}
--------------------
Statistical analysis has been performed using one-tailed Student\'s *t*-test for two group comparisons and one- or two-way ANOVA for three or more group comparisons using the PRISM software (GraphPad Software, La Jolla, CA, USA).
*Conflict of Interest statement*. None declared.
FUNDING {#s5}
=======
This work was supported by Telethon---Italy (GGP07063 and GGP14039) to A.P.; AriSLA Foundation Italy (ALS_HSPB8) to A.P.; Italian Ministry of Labour, Health and Social Affairs (Convenzione Fondazione Mondino/UNIMI) to A.P. and (Giovani Ricercatori) to V.C.; Regione Lombardia to A.P.; Universita' degli Studi di Milano to A.P. and P.R.; Fondazione CARIPLO (2008-2307) to A.P.; Fondation Thierry Latran, France (FTL n. AAP091102) to A.P., Association Française contre les Myopathies (project n. 16406) to A.P. Funding to pay the Open Access publication charges for this article was provided by Fondazione Telethon, Italy.
[^1]: E.G. and P.R. equally contributed to this study.
WO 2013/139685 A1 relates to a valve for an inhalation device comprising a base in the form of a ring defining a central opening, as well as an upper surface and a lower |
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] | respect to extended-spectrum beta-lactamase or plasmid-mediated AmpC beta-lactamase phenotypes, 24 *E. coli* (6.9%) were tested positive for extended-spectrum beta-lactamase or plasmid-mediated AmpC beta-lactamase and 322 isolates (93.1%), negative. Comparing the resistance rate of antibiotics according to the ESBL/PABL positivity, resistance rates of TMO, FEP, CIP and SMX were significantly higher in ESBL/PABL-positive than ESBL/PABL-negative isolates: 12.5% vs. 2.5% (*P*= 0.033); 20.8% vs. 0% (*P*\<0.001); 83.3% vs. 17.4% (*P*\<0.001) and 50% vs. 27.6% (*P*=0.02), respectively ([Table 2](#T2){ref-type="table"}). Conversely, the resistance rate of FM and NI did not differ: 0% vs. 0%, *P*=0.143; 0% vs. 0.6%, *P*=0.267. Likewise, MIC~50~ and MIC~90~ values of TMO, FEP, CIP and SMX were higher in ESBL/PABL-positive than ESBL/PABL-negative *E. coli* isolates, but those values of FM and NI did not differ between the 2 groups.
In this study, we evaluated the in vitro susceptibility of *E. coli* isolates from CA-UTI to candidate antibiotics for lower UTI such as FM, NI and TMO, which have a therapeutic efficacy but give a relatively low antibiotic selective pressure. The three antibiotics had an excellent susceptibility profile, mainly because FM is not commonly prescribed, and TMO and NI are not available in Korea. We compared the susceptibility of the three antibiotics with CIP, SMX and FEP which are major antibiotics for the treatment of CA-UTI as well as other serious infections. CIP, SMX and FEP belong to a different family of antibiotics with a different resistance mechanism, but uropathogenic *E. coli* commonly shows a co-resistance against CIP, SMX and FEP. Co-resistance rates of CIP and SMX or CIP, SMX and extended-spectrum cephalosporins were 10.6%-12.8% or 1.3%-3.8% in our previous report ([@B9]). Interestingly, FM and NI did not show a tendency for co-resistance with CIP or FEP, but ESBL/PABL-positive isolates were more resistant to TMO in this study. Temocillin is a narrow-spectrum penicillin and known to be resistant to hydrolysis by penicillinase, extended-spectrum beta-lactamases, and AmpC enzymes ([@B10]). However, 3 of 24 ESBL/PABL-positive isolates, possibly with change of membrane permeability, were resistant to TMO in a previous study ([@B11]). In this study, 11 of 346 *E. coli* were resistant to TMO at the breakpoint of 8 µg/mL, and 6 of the eleven were resistant at the British Society for Antimicrobial Chemotherapy (BSAC) urinary breakpoint (32 mg/L) ([@B12]). In terms of NI and FM, only 1 isolate was resistant to NI, which was resistant to TMO and SMX but susceptible to CIP, FM and FEP, and there was no *E. coli* resistant to FM among 346 isolates from CA-UTI. Based on these findings, FM, NI and TMO are an excellent therapeutic option for lower UTI in Korea. As we described, FQ and extended-spectrum cephalosporins are major antibiotics for treatment of UTI as well as other serious infections, and uropathogens showed a tendency for co-resistance to both major drugs. Therefore, it is mandatory to decrease the use of FQ and extended-spectrum cephalosporins for common but not-serious infections such as lower UTI. Instead, nationwide introduction of TMO, NI in addition to FM for treatment of lower UTI should be considered.
In conclusion, resistance rate of *E. coli* from CA-UTI to CIP and SMX were above 20% in Korea. However, TMO, FM and NI showed an excellent activity to them. Therefore, we propose TMO, FM and NI as the first-line antimicrobial agent for CA-lower UTI.
This work was supported by a grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A084063).
The authors have no conflicts of interest to disclose.
{#F1}
######
Comparison of antimicrobial susceptibility according to ciprofloxacin-resistance in *E. coli* isolates from community-acquired UTI
MIC~50~ and MIC~90~, MIC for 50% and 90% of the isolates respectively. ^\*^*P* value\<0.05 was significant by chi-square test or Fisher\'s exact test. CIP-R, ciprofloxacin resistant; CIP-S, ciprofloxacin-susceptible; FM, fosfomycin; CIP, ciprofloxacin; FEP, cefepime; TMO, temocillin; NI, nitrofurantoin; SMX, Trimethoprim-sulfamethoxazole; MIC, minimal inhibitory concentration.
######
Comparison of antimicrobial susceptibility according to ESBL/PABL-positivity in *E. coli* isolates from community-acquired UTI
MIC~50~ and MIC~90~, MIC for 50% and 90% of the isolates respectively. ^\*^*P* value\<0.05 by chi-square test or Fisher\'s exact test. ESBL, extended-spectrum beta-lactamase; PABL, plasmid-mediated AmpC beta-lactamase; FM, fosfomycin; CIP, ciprofloxacin; FEP, cefepime; TMO, temocillin; NI, nitrofurantoin; SMX, Trimethoprim-sulfamethoxazole; MIC, minimal inhibitory concentration.
[^1]: ^\*^Mi-Ran Seo and Seong-Jong Kim contributed equally to this work.
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187,
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1981,
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187,
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281,
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731,
13,
323,
247,
2129,
15,
2058,
11051,
376
] | a kilo of_ skorpios _, scorpion fish, cleaned but left whole. It was a triumph. If you wish, you may substitute a combination of two red mullet, filleted; six large prawns; and 500 g (1 lb) of mixed mussels and clams – you can still follow the method below._
SERVES 4–6
Cook 3 potatoes, sliced, in a deep frying pan with light olive oil and add a very finely chopped onion; then add a glass of white wine and boil furiously, so that the alcohol evaporates. Add the pulp, minus seeds and skins, of 4 tomatoes, a teaspoon of hot paprika, a tablespoon of chopped parsley with the stalks, some black pepper and, if you wish, a teaspoon of tomato paste. Cover this with a lid and add a little hot water from the kettle, then simmer until the potatoes are completely soft.
In a blender, add a chopped garlic clove to a little olive oil and blend to make a thick, pungent paste. Add this when your sauce is amalgamated and the potatoes are completely soft. Then place the fish on top of this mixture and poach them while the sauce reduces, so that the fish is moist and perfectly cooked, and stands a little proud of the sauce. Serve in deep, warm bowls.
CHAPTER 5
WILD THINGS
THE DEATH OF PAN
_According to the first-century historian Plutarch, one night a boat was sailing through the dark, close to the island of Paxos; most of the passengers were still awake. Suddenly they heard a strange voice, which seemed to be coming over the water from the island. It called, 'Thamus!' 'Thamus!' – which was the name of the captain of the vessel. He remained silent and afraid; but it called again and again. Finally he answered and the voice said, 'Go to the harbour near Butrinto, and announce... that the Great Pan is dead.'_
_Thamus did as he was told (Butrinto is on the Albanian side of the Corfu channel, just north of Paxos) and immediately there was wailing of astonishment and grief from all who heard him. The news travelled fast to Rome, where Tiberius Caesar himself called Thamus to come before him. Pan, the god of animals and all wild things; Pan, the hoof-footed piper at the gates of dawn... all felt shocked and somehow bereft at the death of a god._
_But a hundred years later, when the Roman writer and scholar Pausanias toured Greece, he found that Pan's shrines and sacred caves were still visited and revered. And sometimes, when walking alone over the cliffs in the early morning, the sounds of hidden birds and a rustling through the trees make one fleetingly conscious – like a flash across one's peripheral vision – of the presence of something..._
_HORTA_
_Rumps in the air, bent deeply at the waist, women – from widows to very young girls – are to be seen all over the island of Paxos in March and April, gathering the first luscious green shoots of spring. The Greeks have a passion for all these bitter-sweet weeds, known as_ horta _. Electra and her two friends, both called Nitza, know by sight those which are good for salads or for cooking._
_The ancients loved peppery, bitter leaves and they searched out the bulbs of grape hyacinths, which stud the hillside with miniature patches of blue._ _Today's islanders love them too, adding spinach, chard, lovage and sorrel._
_Famine is within living memory. During the German occupation of Athens in the last war, an estimated 300,000 starved to death; their bodies were collected off the street each morning. So great was the hunger that the hills were stripped bare of wild greens... war-time was tough on the island, too. Today, when you see strapping teenagers towering above their tiny grandparents, you reflect on the dramatic change in diet._ Horta _are still treasured. They are free, growing abundantly on hillsides, at the cost of a little stooping to pick them, with no expensive imports by boat._
Radíkia _encompasses wild chicories, dandelions and all kinds of bitter leaves. Greeks cook the leaves and shoots of mallow; they look out for wood sorrel and field sorrel. They seize upon comfrey leaves, wild fennel and wild beets,_ vlíta.
_Serve your weeds steamed, tossed in some good olive oil, with lemon tears and lemon zest; wilted, with a little minced garlic, or some olives; buttered, especially if you have spinach and chard, with mint; or chopped, ready for stuffing in pasta, in which case a generous grind of nutmeg would be splendid._ _Add chopped drained_ horta _to little pastry tarts, topped with olives, capers anchovies, béchamel or hollandaise... purists select the finest little leaves for a salad, with a few slices of radish or raw carrot, and droplets of cold-pressed extra-virgin olive oil._
WILD GREEN SOUP
_This can be made from a basketful of leafy vegetables; or, very pleasingly, from the three witches that curse our gardens: nettles, dandelions and ground elder. Pick only the dainty young leaves of the nettles, young ground elder leaves and small dandelion leaves._
SERVES 4
150 g (5 oz) young nettle tops, dandelion leaves and ground elder; mixed with spinach or chard (optional)
2 tablespoons basmati rice
1 litre (1¾ pints/4 cups) vegetable or chicken stock
1 onion, peeled and finely chopped
2 leeks, trimmed, washed and finely sliced
2 stalks celery, chopped
50 g (2 oz) butter
Greek yoghurt to serve
fresh mint leaves to garnish
sea salt and black pepper
Wash the greens thoroughly, using rubber gloves when touching the nettles, and discard any tough stalks. Wash the rice to remove the starch and add to a pan with the chicken stock, then simmer until the grains of rice are soft.
Sweat the onion, leek and celery in butter in a large frying pan; cover and allow to cook gently for 10 minutes, stirring occasionally, until soft, but do not allow it to brown.
Add the rice and stock to the pan, bring it to a simmer and cook for a further 10 minutes. Then add the wild greens, stirring them as they wilt; simmer them until the rice and nettles are tender. Season with salt and plenty of pepper. Purée the soup in batches, re-heat – but do not allow it to boil. Serve in warm bowls with a swirl of yoghurt and a little chopped mint on top.
Note: if kept too long, the bright green colour will be lost, so if you need to make this ahead, prepare till just before you add the greens, and cook them when you want to eat.
FORAGING ON THE SHORE
_In February, seemingly without fail, there are ten days of surprising warm weather. The sea is glassily calm; the balmy air suggests, deceptively, that spring has arrived. These are the_ alkionides meres _, the halcyon days – thanks to Alcyone, for whom Zeus had a passion. When his wife Hera found out, she changed Alcyone into a bird – and Zeus compassionately gave Alcyone ten days of calm weather, in which to lay her eggs... The Paxiots take advantage of this by going down to the seashore to gather limpets, snails and seaweeds._ _One seaweed is named_ oneira _– which means dream; these beautiful green and white weeds float just under the water. They use them for a salad with limpets, and some rice._
_The tiniest limpets are_ patales _– a great delicacy. They are pure gellified obstinacy to remove, so use the sharp tip of one shell as a lever to prise out the limpet, and swallow it raw, to taste the sea. There are cone-shaped limpets, too; their raw flesh is blended and eaten on top of fried rice._
SAMPHIRE
_We in Britain are lucky enough to have samphire, as the Greeks do; why do so few appreciate it? It is my favourite wild food. Take a piece of plainly grilled fish, dressed in a little oil, with lemon juice and rock salt in which a few dried fragments of oregano have been pounded. Serve it with a warm dish of_ krìtamo _: tiny green stems of samphire that have been blanched very briefly, then anointed with a little lemon juice, the very best olive oil, and dressed with some 'tears' of lemon segments... a dish with an incredible depth of flavour._ _When preserved in white wine vinegar, samphire can be used in winter salads._
SNAILS
_After winter hibernation, snails come out in the spring showers – and are promptly collected by young and old. They are fed only garden greens, to purge them, for a week. At Electra |
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] | applied to newborn piglets, those receiving the highest score of 4 had lower blood pCO~2~, higher pH and lower lactate and glucose than those with the lowest liveborn score of 2 \[[@B11-animals-09-00885]\], indicating that they had suffered less birth asphyxia. In support of this, piglets with severe meconium staining (\>40% covering of the skin) recorded a lower viability score at birth \[[@B46-animals-09-00885]\]. Viability is important as locating the sow's udder and outcompeting littermates ensures access to colostrum/milk. Time taken for the piglet to reach the udder was reported to increase with increased pCO~2~ and blood lactate as well as with decreased pH \[[@B11-animals-09-00885]\]; meconium-stained piglets took twice as long to contact the sow's udder than unstained piglets \[[@B46-animals-09-00885]\]. Langendijk, et al. \[[@B12-animals-09-00885]\] showed that asphyxia impacted on the time it took a piglet to successfully feed and most importantly, the volume of colostrum ingested. Piglets with high lactate levels were slower to feed and took in less colostrum than those without evidence of asphyxia. The measurement of such behaviours is important given the link between colostrum intake and piglet survival \[[@B47-animals-09-00885]\]. Catecholamines are released to stimulate liver glycogenolysis after asphyxia \[[@B11-animals-09-00885]\]. Because of this, piglets that are asphyxiated \[[@B11-animals-09-00885],[@B32-animals-09-00885]\] and that die during the first ten days \[[@B48-animals-09-00885]\] display elevated blood glucose levels. So, taken collectively, asphyxiated piglets have lower vitality which will compromise feeding and mobilise glycogen stores at a rapid rate, making hypoglycaemia likely. Therefore, it is imperative to restore glucose levels in asphyxiated piglets immediately and employ colostrum management strategies such as those outlined by Alexopoulos, et al. \[[@B47-animals-09-00885]\].
Asphyxiated piglets also struggle with regards to temperature homeostasis. Heavily meconium-stained piglets recorded rectal temperatures 1.7 °C cooler at birth than those with little to no staining \[[@B46-animals-09-00885]\]. Rectal temperature at 24 h of age has also shown to increase with pH and with decreased pCO~2~ and lactate \[[@B11-animals-09-00885]\], and so the negative effect of birth trauma on temperature is maintained in the days following birth. However, Herpin, et al. \[[@B49-animals-09-00885]\] suggested that it is not homeothermy per se that is impaired in asphyxiated piglets, but rather the link between birth trauma, colostrum intake and carbohydrate metabolism (explored in the previous paragraph) that results in the low body temperature. Regardless, with reduced rectal temperature, these piglets are at increased risk of chilling. Thoresen, et al. \[[@B50-animals-09-00885]\] identified that secondary energy failure was reduced when piglets were cooled to 35 °C for 12 h after induced asphyxia, with this finding and others being responsible for the clinical application of therapeutic hypothermia for treatment of human neonatal hypoxic-ischemic encephalopathy. Thus, the commonly reported hypothermia in asphyxiated piglets may have neuroprotective effects. How to manage the rewarming event then becomes contentious. Wang, et al. \[[@B51-animals-09-00885]\] identified increased apoptosis when rewarming was rapid rather than slow (i.e., 2 h versus 8 h), and so a more gradual increase in body temperature of chilled piglets would result in the highest success rate.
Given these impacts on a piglets ability to thermoregulate and ingest colostrum, perhaps it is not surprising that when no additional care is provided, mortality in the first week of life is doubled from 5.5% to almost 11% in asphyxiated piglets \[[@B12-animals-09-00885]\]. In addition to survival being reduced, piglet growth is compromised when birth trauma is experienced. When piglets are exposed to asphyxia, blood flow is reduced to the small and large intestines during the event, which resulted in intestinal lesions at 12 h of age \[[@B52-animals-09-00885]\]. Such damage to the gastro-intestinal tract would have ramifications for milk and colostrum absorption. Indeed, piglets with heavy meconium staining gained 168 g by day 5, compared with 520 g for control piglets \[[@B46-animals-09-00885]\]. By ten days of life, average daily gain (ADG) was shown to be inversely related to blood lactate levels at birth \[[@B11-animals-09-00885]\]. At weaning, ADG was reduced from 259 g/d to 245 g/d in least versus most asphyxiated piglets, respectively; from weaning to 10 weeks ADG was reduced from 721 g/d to 664 g/d in least versus most asphyxiated piglets, respectively \[[@B12-animals-09-00885]\]. From these studies, it is evident that asphyxiated piglets perform poorly with regards to growth not only in the farrowing house, but after the weaning event also. What is less clear is the mechanism behind the reduced growth rates. Is it simply that the less viable pigs ingested low colostrum levels (with colostrum intake influencing growth to six weeks of age \[[@B53-animals-09-00885]\]), or are there longer term impacts of asphyxia on the physiology and development of the pig? Ralph, et al. \[[@B54-animals-09-00885]\] demonstrated behavioural differences at the end of lactation (day 21) in piglets heavily stained with meconium suggestive of neurological shifts that persist outside the perinatal period. Further work examining whether there are long term gastro-intestinal changes in piglets experiencing asphyxia are warranted.
9. Conclusions {#sec9-animals-09-00885}
==============
Using conservative estimates from this review, 10% of piglets are stillborn and 15% of those born alive are at an increased risk of significant morbidity and mortality from birth trauma. Assuming a total litter size of 15, this equates to 3--4 viable piglets per litter that will be affected by asphyxia, a figure that will only rise with increased prolificacy. The parturition process is almost exclusively responsible, with cumulative farrowing duration rather than birth interval explaining most of the damage to piglets. Interestingly, sows at risk of delivering asphyxiated piglets are already compromised before the expulsive phase. This means that interventions that are applied during the second phase when piglets are birthed will have little impact, and in some cases, may actually increase the odds of a dead or low-viability piglet. Asphyxiated piglets require special care immediately after birth as the condition impairs glucose and temperature homeostasis. Identifying ways to correctly manage the sow before parturition leading to a reduction in farrowing duration should be a priority in order to maximise piglet performance.
P.L. and K.P. contributed equally to all aspects of this publication.
This research received no external funding.
The authors declare no conflict of interest.
{#animals-09-00885-f001}
![Effect of birth order on stillbirth (**left panel**) and measures of asphyxia (**right panel**) \[[@B12-animals-09-00885]\].](animals-09-00885-g002){#animals-09-00885-f002}
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] | B5 2 No No 19200 19200 0.0% 474 bytes optiboot_flash_atmega88_UART0_19200_22118400L_B5.hex
20000000L UART0 B5 2 No No 500000 500000 0.0% 474 bytes optiboot_flash_atmega88_UART0_500000_20000000L_B5.hex
20000000L UART0 B5 2 No No 250000 250000 0.0% 474 bytes optiboot_flash_atmega88_UART0_250000_20000000L_B5.hex
20000000L UART0 B5 2 No No 115200 113636 -1.3% 474 bytes optiboot_flash_atmega88_UART0_115200_20000000L_B5.hex
20000000L UART0 B5 2 No No 19200 19230 0.1% 474 bytes optiboot_flash_atmega88_UART0_19200_20000000L_B5.hex
18432000L UART0 B5 2 No No 460800 460800 0.0% 474 bytes optiboot_flash_atmega88_UART0_460800_18432000L_B5.hex
18432000L UART0 B5 2 No No 230400 230400 0.0% 474 bytes optiboot_flash_atmega88_UART0_230400_18432000L_B5.hex
18432000L UART0 B5 2 No No 115200 115200 0.0% 474 bytes optiboot_flash_atmega88_UART0_115200_18432000L_B5.hex
18432000L UART0 B5 2 No No 57600 57600 0.0% 474 bytes optiboot_flash_atmega88_UART0_57600_18432000L_B5.hex
18432000L UART0 B5 2 No No 38400 38400 0.0% 474 bytes optiboot_flash_atmega88_UART0_38400_18432000L_B5.hex
18432000L UART0 B5 2 No No 19200 19200 0.0% 474 bytes optiboot_flash_atmega88_UART0_19200_18432000L_B5.hex
18432000L UART0 B5 2 No No 9600 9600 0.0% 474 bytes optiboot_flash_atmega88_UART0_9600_18432000L_B5.hex
16000000L UART0 B5 2 No No 1000000 1000000 0.0% 474 bytes optiboot_flash_atmega88_UART0_1000000_16000000L_B5.hex
16000000L UART0 B5 2 No No 500000 500000 0.0% 474 bytes optiboot_flash_atmega88_UART0_500000_16000000L_B5.hex
16000000L UART0 B5 2 No No 250000 250000 0.0% 474 bytes optiboot_flash_atmega88_UART0_250000_16000000L_B5.hex
16000000L UART0 B5 2 No No 115200 117647 2.1% 474 bytes optiboot_flash_atmega88_UART0_115200_16000000L_B5.hex
16000000L UART0 B5 2 No No 38400 38461 0.1% 474 bytes optiboot_flash_atmega88_UART0_38400_16000000L_B5.hex
16000000L UART0 B5 2 No No 19200 19230 0.1% 474 bytes optiboot_flash_atmega88_UART0_19200_16000000L_B5.hex
16000000L UART0 B5 2 No No 9600 9615 0.1% 474 bytes optiboot_flash_atmega88_UART0_9600_16000000L_B5.hex
14745600L UART0 B5 2 No No 460800 460800 0.0% 474 bytes optiboot_flash_atmega88_UART0_460800_14745600L_B5.hex
14745600L UART0 B5 2 No No 230400 230400 0.0% 474 bytes optiboot_flash_atmega88_UART0_230400_14745600L_B5.hex
14745600L UART0 B5 2 No No 115200 115200 0.0% 474 bytes optiboot_flash_atmega88_UART0_115200_14745600L_B5.hex
14745600L UART0 B5 2 No No 57600 57600 0.0% 474 bytes optiboot_flash_atmega88_UART0_57600_14745600L_B5.hex
14745600L UART0 B5 2 No No 38400 38400 0.0% 474 bytes optiboot_flash_atmega88_UART0_38400_14745600L_B5.hex
14745600L UART0 B5 2 No No 19200 19200 0.0% 474 bytes optiboot_flash_atmega88_UART0_19200_14745600L_B5.hex
14745600L UART0 B5 2 No No 9600 9600 0.0% 474 bytes optiboot_flash_atmega88_UART0_9600_14745600L_B5.hex
12000000L UART0 B5 2 No No 500000 500000 0.0% 472 bytes optiboot_flash_atmega88_UART0_500000_12000000L_B5.hex
12000000L UART0 B5 2 No No 250000 250000 0.0% 472 bytes optiboot_flash_atmega88_UART0_250000_12000000L_B5.hex
12000000L UART0 B5 2 No No 57600 57692 0.1% 474 bytes optiboot_flash_atmega88_UART0_57600_12000000L_B5.hex
12000000L UART0 B5 2 No No 19200 19230 0.1% 474 bytes optiboot_flash_atmega88_UART0_19200_12000000L_B5.hex
12000000L UART0 B5 2 No No 9600 9615 0.1% 474 bytes optiboot_flash_atmega88_UART0_9600_12000000L_B5.hex
11059200L UART0 B5 2 No No 460800 460800 0.0% 472 bytes optiboot_flash_atmega88_UART0_460800_11059200L_B5.hex
11059200L UART0 B5 2 No No 230400 230400 0.0% 472 bytes |
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559
] | is divided by a.
5
Let u be (-6)/((-5)/(220/8)). Suppose -6*c + u = -63. Calculate the remainder when c is divided by 9.
7
Calculate the remainder when 27 is divided by (-2)/11 + (2 - (-72)/33).
3
Let h = 27 - -31. What is the remainder when h is divided by 12?
10
Suppose -4*i - 14 + 4 = -5*u, -6 = -3*u + 5*i. Suppose 0 = -4*p + u*p + 36. What is the remainder when p is divided by 10?
8
Let m(j) = 19*j - 43. What is the remainder when 119 is divided by m(3)?
7
What is the remainder when -3 - ((-1)/(-5) + 964/(-20)) is divided by 11?
1
Suppose -4 = 5*y - 24. Suppose 4*j - 2 = 3*o + 12, -2*o = -j + 6. Calculate the remainder when 23 is divided by (8 - y)/((-1)/o).
7
Let y = 174 - 305. Let x = y - -188. Calculate the remainder when x is divided by 20.
17
Let p(g) = g**2 + 4. Let m be p(0). Suppose 5*k + m*c = k + 68, 61 = 3*k - 2*c. What is the remainder when 54 is divided by k?
16
Suppose -z - 5 = -41. Let t = z - -21. What is the remainder when t is divided by 20?
17
Let w(g) = -16*g - 29. Let f(o) = -5*o - 10. Let n(r) = 17*f(r) - 6*w(r). What is the remainder when n(5) is divided by 20?
19
Suppose 5*h - 80 = 20. Suppose 0 = -2*f - 2*f + h. What is the remainder when 13 is divided by f?
3
Let w(m) = m**3 + 5*m**2 - 2*m + 1. Calculate the remainder when 98 is divided by w(-4).
23
Let a(t) = 2*t + 2. Let b be a(2). Let n(i) = -i**3 + 5*i**2 + 7*i - 8. Let f be n(b). Calculate the remainder when 32 is divided by 112/10 + f/10.
10
Suppose 4*y = -y + 80. Let a = y + 9. Calculate the remainder when a is divided by 9.
7
Suppose -5*v + 69 = -46. Let f be -4*3/(-9)*3. Suppose -l + f = -4. Calculate the remainder when v is divided by l.
7
Suppose -3*p + 4*p - 15 = 0. What is the remainder when p is divided by 4?
3
Suppose -4*g - 3 = -43. Suppose -v + 6 = 2*v. Suppose -v*b - i = -24, 3*b + g*i - 29 = 5*i. What is the remainder when b is divided by 8?
5
Suppose g + 4*g = 5*w - 105, 3*w = 5*g + 73. Calculate the remainder when 29 is divided by w.
13
Suppose -4*i + 3*i = -5. Suppose 0 = 2*h - 0*h + 3*t - 12, i*t - 4 = 2*h. What is the remainder when h is divided by (-1)/2 - 25/(-10)?
1
Let u = 0 + -2. What is the remainder when 57 is divided by 360/27*(-3)/u?
17
Suppose 0 = -4*r + 6 + 2. Suppose -w + 98 = -5*t, -r*t - 2*t - w - 82 = 0. Let j = t + 33. Calculate the remainder when j is divided by 7.
6
Suppose -2*f + 60 = 2*g, -f + 4*g + 30 = -0*f. Let m = f - 24. What is the remainder when 9 is divided by m?
3
Let x(m) = -10*m - 17*m - 7 + 24*m. Calculate the remainder when 30 is divided by x(-6).
8
Let y be (-16)/88 - (-26)/22. What is the remainder when 4/y*330/40 is divided by 9?
6
Suppose 0*w + t = -4*w + 30, -5*w - t = -37. What is the remainder when 16 is divided by w?
2
Let y(a) = 8*a**2 + 2*a + 1. Let c be y(-1). Let d = c + -4. Suppose 0*h + 3*h - l - 24 = 0, d*h = -l + 30. Calculate the remainder when 16 is divided by h.
7
Suppose -4*i - 1 + 5 = 0. Let s be 4*1*1/i. Suppose -s*p + 16 = -0*p. What is the remainder when 10 is divided by p?
2
Let f = -6 + 4. Let h be (12/8)/((-1)/f). Suppose -h = -3*n + 6, -4*j - 3*n = -77. Calculate the remainder when 49 is divided by j.
15
Suppose 0*o - 3*o = -t, 0 = -o. Suppose -3*a + 4*v + 35 = -2*a, -4*a + 3*v + 192 = t. What is the remainder when a is divided by 13?
12
Suppose 0 = 2*h + h + 99. Let f = 46 + h. Calculate the remainder when f is divided by 8.
5
Let p = -3 + 65. Calculate the remainder when p is divided by 33.
29
Suppose 9*j - 51 = -8*j. Suppose 4*x - 32 = -g - 2*g, 3*g + 5*x - 34 = 0. What is the remainder when g is divided by j?
2
Suppose -2*n + 3*n = 27. Calculate the remainder when n is divided by (((-1)/3)/1)/(3/(-126)).
13
Suppose -3*y + 0*y = -3*i + 24, 0 = 4*y - 3*i + 33. Let z = y + 21. Let s = z + -7. Calculate the remainder when s is divided by 2.
1
Suppose 2*a + 10 = -0*a, -105 = 4*p + 5*a. What is the remainder when p/(-6) - 2/6 is divided by 1?
0
Calculate the remainder when (10/25)/(1/85) is divided by 12.
10
Suppose 8 = -4*t + 5*m, t + 0 = -2*m - 15. Let b = -44 - -123. What is the remainder when 21 is divided by b/7 + 2/t?
10
Let i(f) = -f**3 + 1 + 1 + 1. Let y(j) = -11*j - 36. What is the remainder when y(-4) is divided by i(0)?
2
Suppose 3*r + 46 = 169. What is the remainder when r is divided by 14?
13
Let z = -20 + 44. Calculate the remainder when z is divided by 13.
11
Let w(t) = -4*t - 3. Let k be w(-5). Let g = k + 28. Suppose -4*i + 107 - 15 = 0. What is the remainder when g is divided by i?
22
Suppose -3*r - u + 31 = 0, 5 = -4*r + 5*r - 5*u. What is the remainder when 27 is divided by r?
7
Let k(s) = 2*s - 2. Let i(o) = -3*o - 7. Let c be i(-5). Calculate the remainder when 35/2*c/5 is divided by k(6).
8
Suppose -2*o = -106 - 94. What is the remainder when o is divided by 34?
32
Let p(t) = t**3 + 7*t**2 - 7*t + 5. Let s(z) = 2*z + 6. Let f be s(-7). Let r be p(f). What is the remainder when (-4 - r)/((-1)/23) is divided by 12?
11
Let a(g) = g**3 - 6*g**2 + 2*g - 1. Let d be a(6). Suppose -5 = -5*k - 0. Let j = k + d. What is the remainder when 35 is divided by j?
11
Suppose 3*i + 125 = -2*i. Let c = -16 - i. Let o(x) = -x**3 + |
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] | continent’s north-east.
And to make it even worse, native animal populations drop wherever the cane toad spreads – due to competition for resources and also the fact that most predators who eat them get poisoned.
When threatened, cane toads ooze white poison called bufotoxin from parotid glands on their backs. According to the Global Invasive Species Database, it’s been known to kill cats, dogs, snakes, lizards and even humans.
There are programs to try and train animals away from eating cane toads, but Australian crows (Corvus orru) don’t need any of that.
These birds have figured out how to get a meal and how not to get poisoned – and now an Australian nature photographer has captured a crow in action:
“These clever birds have learnt to roll the toads onto their backs, sometimes doing so repeatedly if the luckless toad tries to hop away. Crows know which bits to eat – fleshy thighs, tongues, intestines – and how to get at these from below without contacting the lethal parts.”
It’s probably more a testament to the crows’ cleverness than a solution to the cane toad conundrum.Customer reviews of our Photo Graduation Announcements
May 11, 2015Take a close look
"We ordered this card for our daughter's High School graduation. The cards printed beautifully, but make sure you look closely at the printed wording side to notice there are markings on the black background. We did not look closely enough and I thought they were smudges. The fault was mine for not looking closely enough, but the rest of the card is beautiful."
January 27, 2014Beautiful Card
"This was the perfect card at the right price! The pictures turned out great,& it was a very stylish more expensive looking card without the high cost. Love it!"
June 12, 2013Great looking
"The card looked great, I loved the layout and was overall happy with the quality. We were proud to send it out to family and friends."So, Here’s the “Why”
In Tableau, we are easily able to slice and dice the data according to our dimensions thanks to the default manner in which Tableau aggregates the data on our behalf. Therefore, I can simply add any measure and trust the view is appropriate at that level; from an overview, down to the finest level of detail, Tableau aggregates accordingly. But what happens when we have aggregate data, and we need to re-aggregate?
For instance, what if I want to categorize and then summarize my sales data at a higher level than what currently exists in my data? As indicated in the picture below, my sales data is actually down to the item level for each customers’ purchase.
Let’s say I would like to classify purchasers based on the overall amount they have spent rather than by each individual transaction. I don’t currently have any dimension in the data set that categorizes these sales, but there are a few ways I can create a solution in Tableau.
I could create a conditional filter, or perhaps a series of sets for each one of these categories, but each would only allow me to view one category at a time. Most likely, I would build a custom calculation to create a new dimension in Tableau. I decided to create the following calculated field.
The following calculation gives me the result I’m looking for; or so I think. This calculation allows me to view the sales classification against the entire data set to see the proportion of all categories at one time, but I wouldn’t be able to view a customer level summary with this calculation because it is performing at the row level, which is per each item sold (added color for emphasis of applied calculation).
Although I can view the classification for each item that was sold, I’m interested in what my customer’s total spending level is. For example, if you view Customer #1, the overall sales total just over $19k, but according to our calculation, the sales classification is being made for each item that Customer #1 has purchased, sometimes multiple items per order. “Just remove the Item and Order levels,” you say. Let’s see what happens as a result.
Thankfully, and unfortunately in this case, Tableau is still properly applying our row level calculation according to each item every customer has purchased. So, why is there only two entries, and why is one entry over $18k and colored orange according to the $9,999 – $5,000 range? If you look carefully at the previous screen shot, Tableau has summed up all like classifications. We had three items for Customer #1, each item in the $9,999 – $5,000 range, totaling $18,624. The rest were all items at or below the $4,999 threshold. Not exactly the result we intended. The calculation is unable to roll up according to the Customer level. But wait…here’s the great news. We can once again utilize the power of extracts to help for this scenario!
So, here’s the “HOW”…
In order to fix this, we can create an extract and aggregate the data according to the level that we’re interested in (I hope now you’re now saying to yourself, “So that’s what that check box is for”). First, we simply hide all of the levels of detail that will interfere, or be of finer grain, than the level we are interested in, which happens to be Customer ID. Therefore, if we hide the Item and Order ID, Tableau will aggregate the sales to a higher level, allowing us to see sales by customer (I am hiding all of the unnecessary dimensions for simplicity of the example).
From this point, we can create our Extract, making sure to “Aggregate data for visible dimensions.”
Now, we can see our calculation applied to the Customer level.
Now that our calculation is being applied in the manner in which we were hoping, we can use it more functionally across the data set to see a summary of our customers (below TOP) versus the Item level (below BOTTOM) which skews our summary results and show us every record (item) instead of looking at our customers.
Please feel free to comment or email with any questions and/or suggestions on this post. Happy extracting!Martin Smith (figure skater)
Martin Smith (born January 14, 1968) is a Canadian former competitive ice dancer. With Jo-Anne Borlase, he is the 1989 NHK Trophy bronze medalist, 1989 Skate America bronze medalist, and 1990 Canadian national champion. With Michelle McDonald, he won the 1991 Canadian national title.
Career
Early in his career, Smith skated in partnership with Melanie Cole. The two placed fourth at the 1986 World Junior Championships, which took place in December 1985 in Sarajevo, and won the Canadian national junior title the same season. The following season, they competed on the senior level, placing 8th at the 1986 Skate America.
In 1987, Smith teamed up with Jo-Anne Borlase. In their second season together, they won bronze at the Canadian Championships. In their third, they took bronze at the 1989 Skate America and 1989 NHK Trophy before winning the national title. They finished 7th at their final event together, the 1990 World Championships in Halifax, Nova Scotia.
Smith competed the next two seasons with Michelle McDonald. The two won the 1991 Canadian national title but dropped to third in 1992 and missed out on the Olympics.
Smith represented the Kitchener-Waterloo Skating Club (1986) and the Granite Club (1990 to 1992).
Competitive highlights
With McDonald
With Borlase
With Cole
References
Category:Living people
Category:Canadian male ice dancers
Category:1968 births--! qt:dataset:alltypesorc
set hive.explain.user=false;
SET hive.vectorized.execution.enabled=true;
SET hive.auto.convert.join=true;
SET hive.vectorized.execution.mapjoin.native.enabled=true;
set hive.fetch.task.conversion=none;
-- Using cint and cstring1 in test queries
create table small_alltypesorc1a_n1 as select * from alltypesorc where cint is not null and cstring1 is not null order by ctinyint, csmallint, cint, cbigint, cfloat, cdouble, cstring1, cstring2, ctimestamp1, ctimestamp2, cboolean1, cboolean2 limit 5;
create table small_alltypesorc2a_n1 as select * from alltypesorc where cint is null and cstring1 is not null order by ctinyint, csmallint, cint, cbigint, cfloat, cdouble, cstring1, cstring2, ctimestamp1, ctimestamp2, cboolean1, cboolean2 limit 5;
create table small_alltypesorc3a_n1 as select * from alltypesorc where cint is not null and cstring1 is null order by ctinyint, csmallint, cint, cbigint, cfloat, cdouble, cstring1, cstring2, ctimestamp1, ctimestamp2, cboolean1, cboolean2 limit 5;
create table small_alltypesorc4a_n1 as select * from alltypesorc where cint is null and cstring1 is null order by ctinyint, csmallint, c |
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] | °C for 40 minutes. After adding 5% serum, the sensory epithelia were removed. The remaining pieces of the stromal tissue were transferred into 50 *μ*L of PBS in a six-well culture plate using forceps, combined with 50 *μ*L of prewarmed 0.25% Trypsin/EDTA (Gibco-BRL), and incubated at 37°C for 7 minutes in a CO~2~ incubator. After adding 100 *μ*L DMEM/F12 media supplemented with 10% FBS, the cells were gently triturated and then cultured in a 10 cm culture dish until 80--90% confluency. At the first passage, cells were collected and filtered through a 70 *μ*m strainer (BD Labware) to remove debris. Cells were expanded twice before using as the stromal cells supporting the differentiation of inner ear hair cells. Prior to performing the inner ear hair cell differentiation experiments, the chicken utricle stromal cells were plated onto gelatin-coated six-well dishes (Corning) and grown until 90% confluency. The cells were then mitotically inactivated with 2 *μ*g/mL mitomycin C in DMEM/F12 with 10% FBS for 3 hours and washed three times with media before use for inner ear hair cell differentiation cultures.
The two-step-induction method was used for inducing hair-cell-like cell differentiation from inner ear multipotent cells. Firstly, the cochlear multipotent cells from the tertiary spheres were plated in 24-well dishes coated with poly-L-lysine and then cultured for 7 days to induce the differentiation of progenitor cells of the inner ear cell lineage. The differentiation medium for the inner ear progenitor cell lineage consisted of DMEM/F12 (Invitrogen, mixed 1 : 1), N2 (1 : 100), B27 (1 : 50) (Invitrogen), FGF3 (50 ng/mL, Invitrogen), and FGF10 (50 ng/mL, Invitrogen). After 7 days of differentiation, most of inner ear multipotent cells have differentiated into progenitor cells. Subsequently, we used two substrates, poly-L-lysine and inactivated embryonic chicken utricle stromal cells, for differentiation of progenitor cells into hair cells. For the differentiation on poly-L-lysine, the progenitor cells were continued to be cultured in 24-well dishes coated with poly-L-lysine for another 7 days. For the differentiation on inactivated embryonic chicken utricle stromal cells, the inner ear progenitor cells were separated by a 7-minute treatment with Accutase (Invitrogen) at 37°C and then cultured in 24-well dishes coated with mitotically inactivated E18 chicken utricle stromal cells for 7 days. The differentiation medium for hair cell differentiation was DMEM/F12 (Invitrogen, mixed 1 : 1) medium supplement with N2 (1 : 100), B27 (1 : 50), and DAPT (5 *μ*M, Sigma). The exhausted medium was replaced every second day. Differentiated cells were analyzed by a combination of total RNA preparation followed by reverse transcription-polymerase chain reaction (RT-PCR), immunocytochemistry, and scanning electron microscopy (SEM) or electrophysiology.
2.3. Analysis of Gene Expression Specific for Inner Ear Multipotent Cells and Inner Ear Hair Cells {#sec2.3}
--------------------------------------------------------------------------------------------------
Cells from tertiary spheres and cells differentiated for 7 and 14 days were analyzed for expression of specific genes using RT-PCR. Total RNA was extracted using Trizol reagent (TaKaRa, Shanghai, China) according to manufacturer\'s instructions. RNA (1 *μ*g) was used to synthesize first-strand cDNA by reverse transcriptase (Fermentas, Shanghai, China), and the expression levels of the Nestin, Abcg2, Pax-2, BMP-4, BMP-7, Myosin VIIA, Espin, Brn3c, and P27^kip1^ genes were determined. GAPDH was used as a housekeeper gene for normalization of all measurements. Individual primers across two or more exons were designed using the Primer Express 1.0a software (Applied Biosystems) to discriminate between cDNA and genomic DNA. The resulting cDNAs were used as templates for PCRs using the following primer pairs (forward, reverse, cDNA product length): GAPDH (5′-AAC GGG AAG CCC ATC ACC-3′, 5′-CAG CCT TGG CAG CAC CAG-3′, 442 bp), Nestin (5′-GGA GAG TCG CTT AGA GGT GC-3′, 5′-CTT GGG GTC AGG AAA GCC AA-3′, 334 bp), Abcg2 (5′-GCT GTG GAG CTG TTC GTA GTG G-3′, 5′-GCT AAA GTA CTG AAG CCA GGA C-3′, 387 bp), Pax-2 (5′-CCA AAG TGG TGG ACA AGA TTG CC-3′, 5′-GGA TAG GAA GGA CGC TCA AAG AC-3′, 475 bp), BMP-4 (5′-TGG TAA CCG AAT GCT GAT GGT CG-3′,5′-GTC CAG TAG TCG TGT GAT GAG GTG-3′, 598 bp), BMP-7 (5′-TGG GCT TCT GAG GAG GGC TGG TTG-3′,5′-TGG CGT GGT TGG TGG CGT TCA T-3′, 484 bp), Myosin VIIA (5′-CTC CCT CTA CAT CGC TCT GTT CG-3′, 5′-AAG CAC CTG CTC CTG CTC GTC CAC G-3′, 628 bp), Espin (5′-CAG CCT GAG TCA CCG CAG CCT C-3′, 5′-TGA CCT GTC GCT GCC AGG GCG CG-3′, 475 bp), Brn3c (5′-GCC ATG CGC CGA GTT TGT C-3′, 5′-ATG GCG CCT AGA TGA TGC-3′, 368 bp), P27^kip1^ (5′-CTG GAG CGG ATG GAC GCC AGA C-3′, 5′-CGT CTG CTC CAC AGT GCC AGC-3′, 525 bp). The PCR conditions were 94°C for 5 min, then 35 cycles of 94°C for 30 s, 58°C (Nestin), 58°C (Abcg2), 60°C (Pax-2), 60°C (BMP-4), 60°C (BMP-7), 62°C (Myosin VIIA), 62°C (Espin), 60°C (Brn3c), 62°C (P27^kip1^), and 58°C (GAPDH) for 30 s, and then 72°C for 30 seconds, finally followed by 72°C for 7 minutes. PCR products were electrophoresed in a 1.2% agarose gel and then stained with ethidium bromide. Each PCR product was resolved three times. Stained bands were visualized under UV light and photographed. Band intensities were analyzed quantitatively in triplicates using the ImageJ software, and the expression level of each gene was normalized to that of GAPDH.
2.4. Immunolabeling {#sec2.4}
-------------------
For immunolabeling, cells were fixed in prechilled PBS with 4% paraformaldehyde for 15 minutes and permeabilized in PBS with 0.25% Triton X-100 for 10 minutes at room temperature. Nonspecific binding sites were blocked for 1 hour by PBS with 1% bovine serum albumin and 0.1% Tween 20. The fixed cells were incubated overnight at 4°C with antibodies specific for BrdU (1 : 200, rabbit polyclonal, Sigma); Nestin (1 : 200, rabbit polyclonal, Abcam, Hangzhou, China); Pax-2 (1 : 100, rabbit polyclonal, Abcam); Pax-8 (1 : 10, mouse monoclonal, Abcam); Atoh1 (1 : 300, rabbit polyclonal, Abcam); Myosin VIIA (1 : 200, rabbit polyclonal, Abcam); Espin (1 : 200, rabbit polyclonal, Santa Cruz, Hangzhou, China); Brn3c (1 : 32, mouse monoclonal, Abcam); P27^kip1^ (1 : 1600, mouse monoclonal, Cell Signaling, Hangzhou, China); *α*-tubulin (1 : 200, mouse monoclonal, Invitrogen); and FITC-conjugated phalloidin complex (50 *μ*g/mL, Sigma). Specific labeling was visualized using secondary donkey anti-mouse, anti-goat, or anti-rabbit antibodies conjugated to either Alexa Fluor 488 or Alexa Fluor 568 (Jackson, Hangzhou, China). Nuclei were visualized by staining with 4′,6-diamidino-2-phenylindole (DAPI).
Hair cells exhibit rapid permeation to FM1-43FX, a dye that passes through open mechanotransduction channels \[[@B12]\]. To test the possibility that the differentiated cells expressed functional mechanotransduction channels, cells differentiated for 14 days were incubated in DMEM-F12 containing FM1-43FX (5 *μ*M; Invitrogen) for 10 seconds at room temperature, washed thoroughly in fresh DMEM/F12 medium, fixed in 4% paraformaldehyde, counterstained with DAPI, and finally observed under the fluorescence microscope. Furthermore, immunostaining for Myosin VIIA was performed following FM1-43FX dye treatment |
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15,
187,
187,
8,
1276,
2427,
327,
275,
253,
24092,
273,
4235,
8912,
434,
34660,
313,
3529,
369,
253,
1416,
273,
634,
1246,
2419,
387,
326,
673,
10,
588,
5604,
320,
2908,
15,
187,
187,
8,
2512,
497,
13584,
1131,
1128,
284,
1900,
627,
403,
13584,
1131,
275,
2069,
273,
2137,
13,
390,
17691,
247,
14051,
15742,
273,
2137,
15,
187,
187,
8,
2512,
497,
13557,
665,
574,
46466,
285,
665,
497,
1869,
273,
1077,
4122,
15,
1707,
497,
581,
390,
767,
4283,
18680,
665,
574,
14779,
4833,
285,
908,
352,
10357,
9299,
15,
1707,
497,
1821,
1014,
1078,
253,
3973,
3645,
3660,
665,
497,
27807,
1411,
616,
1211,
2586,
15,
2732,
326,
2137,
627,
497,
2872,
1821,
665,
20981,
432,
18403,
285,
665,
497,
40372,
290,
35922,
285,
2223,
3939,
2758,
273,
253,
22356,
7021,
1293,
3780,
8958,
273,
326,
958,
15,
1244,
1014,
625,
8312,
13,
47281,
1204,
369,
3551,
715,
9796,
342,
247,
2120,
13439,
13521,
273,
27585,
8083,
342,
18816,
13,
42501,
347,
247,
418,
1189,
273,
20000,
285,
7624,
9745,
670,
247,
3158,
990,
281,
253,
2137,
15,
187,
187,
8,
1898,
594,
327,
15,
329,
48094,
33341,
253,
1810,
24453,
30038,
15,
733,
556,
4592,
1078,
275,
2892,
15,
399,
17290,
1417,
352,
588,
1900,
5108,
27,
247,
17538,
29085,
326,
310,
1097,
3939,
285,
8312,
13,
1408,
407,
1110,
665,
6566,
275,
352,
1128,
284,
973,
347,
1110,
665,
7799,
4832,
6351,
13,
1110,
665,
11205,
387,
27585,
1612,
1146,
4845,
275,
616,
3564,
275,
253,
2852,
15,
3808,
273,
436,
588,
1056,
4722,
4361,
15,
1359,
2223,
556,
253,
1072,
12616,
644,
41856,
275,
512,
1175,
6009,
27,
8937,
378,
50057,
329,
50136,
32,
427,
49235,
15,
9859,
637,
275,
253,
1533,
2,
16508,
24828,
46808,
2,
187,
187,
8,
510,
3426,
7162,
10480,
15,
380,
1711,
13,
1711,
2926,
15,
25728,
327,
253,
1072,
3104,
15,
187,
187,
8,
688,
253,
6264,
1533,
13,
275,
253,
9491,
13,
275,
3569,
1495,
15,
25728,
247,
637,
342,
271,
8274,
2454,
1128,
66,
7715,
368,
476,
626,
1361,
35908,
285,
44895,
15,
23626,
18910,
15,
346,
510,
1390,
637,
275,
253,
1533,
3446,
17218,
68,
904,
3966,
904,
3966,
15,
24955,
665,
434,
247,
3626,
323,
253,
2628,
13,
751,
253,
637,
665,
476,
5580,
368,
247,
5328,
20098,
3345,
253,
416,
5432,
15,
187,
187,
8,
7093,
1246,
7773,
13,
6827,
2325,
373,
4379,
13,
3395,
253,
17929,
273,
247,
2176,
1387,
816,
1078,
253,
3973,
3645,
3660,
15,
733,
369,
824,
247,
5322,
1711,
14,
10186,
7773,
1128,
40199,
952,
574,
1900,
6940,
627,
1128,
455,
50174,
13,
2509,
1027,
9351,
273,
2137,
789,
15,
329,
1175,
25186,
36050,
1128,
66,
1175,
14,
13565,
2872,
29066,
17747,
1128,
34403,
273,
247,
1175,
2021,
13,
3392,
574,
644,
271,
7599,
7411,
15,
329,
1175,
7345,
2283,
2182,
627,
1128,
25914,
7636,
407,
512,
521,
1363,
1128,
9328,
11346,
1461,
2821,
616,
19408,
281,
779,
15,
3771,
275,
2087,
3946,
1128,
10984,
314,
3780,
3260,
326,
344,
574,
574,
247,
2714,
3733,
275,
5793,
27205,
1128,
249,
14537,
14,
72,
1169,
15,
187,
187,
8,
1898,
1996,
13,
1078,
253,
6347,
3645,
3660,
13,
2305,
34780,
1128,
1033,
2585,
342,
247,
611,
1128,
27379,
275,
247,
3965,
326,
2147,
29705,
407,
253,
36050,
285,
574,
247,
1798,
3569,
1424,
264,
1128,
1439,
47281,
382,
1128,
1368,
642,
2,
3771,
20000,
1078,
16942,
281,
5321,
253,
1533,
1128,
66,
1424,
264,
9086,
21896,
247,
1563,
327,
253,
12329,
290,
285,
275,
7418,
643,
4343,
17195,
15,
187,
187,
8,
11336,
273,
326,
310,
752,
368,
1663,
971,
281,
871,
13,
6827,
2325,
373,
4379,
1128,
2858,
368,
1849,
1694,
281,
8968,
253,
4114,
806,
13,
247,
1077,
9257,
523,
30487,
581,
15,
2064,
434,
835,
6393,
13268,
369,
2197,
281,
1089,
562,
13,
604,
703,
812,
13,
816,
752,
369,
1469,
327,
15,
187,
187,
8,
2993,
369,
5686,
1078,
619,
673,
15,
309,
35030,
253,
789,
703,
574,
2218,
323,
441,
672,
309,
3735,
253,
2926,
273,
352,
1128,
395,
309,
651,
452,
10490,
281,
452,
1929,
617,
1128,
6689,
9090,
574,
1894,
285,
13216,
15,
187,
187,
8,
25000,
369,
617,
1211,
6416,
1416,
2167,
703,
369,
1900,
1929,
347,
37921,
15,
1500,
858,
1175,
789,
15,
733,
369,
247,
22820,
703,
943,
3150,
594,
2872,
2464,
187,
187,
53,
1135,
566,
574,
644,
2819,
598,
281,
253,
3402,
387,
247,
5406,
534,
323,
690,
1921,
3261,
7615,
15,
733,
369,
247,
11019,
23211,
273,
247,
5006,
434,
1481,
15,
187,
187,
8,
2513,
326,
1128,
43574,
314,
46823,
187,
187,
8,
4374,
4117,
753,
2305,
17453,
15,
686,
2773,
434,
253,
5006,
13651,
30256,
15,
754,
369,
760,
19525,
840,
15,
754,
369,
247,
39680,
273,
247,
1270,
14,
66,
2084,
273,
7477,
15,
2064,
434,
849,
37921,
2427,
281,
253,
4913,
968,
790,
8,
275,
253,
2554,
273,
247,
42766,
1726,
1255,
15,
733,
4455,
247,
1175,
4999,
8310,
1501,
15,
2596,
5082,
626,
2455,
452,
1869,
46823,
344,
9377,
745,
13,
686,
5371,
651,
1705,
273,
352,
2464,
187,
187,
8,
1147,
3589,
626,
1128,
531,
273,
253,
4913,
968,
790,
5554,
2546,
308,
1135,
566,
15,
187,
187,
8,
4013,
642,
13,
619,
11761,
15,
309,
2096,
326,
253,
4913,
968,
790,
497,
417,
3206,
275,
667,
1039,
15,
1292,
627,
497,
2571,
1128,
4297,
6655,
285,
3858,
1128,
296,
16948,
275,
253,
2419,
326,
2360,
15,
380,
7237,
275,
1953,
369,
253,
3522,
273,
247,
20740,
1091,
15,
380,
4454,
273,
4130,
14343,
762,
326,
10699,
574,
281,
320,
5966,
347,
973,
347,
253,
7312,
42448,
15,
2596,
273,
1110,
4454,
7939,
598,
275,
247,
1534,
5133,
15,
380,
6122,
273,
253,
1980,
7345,
670,
5207,
309,
452,
816,
2183,
368,
2210,
1066,
281,
4143,
617,
3392,
347,
703,
2223,
858,
285,
2546,
253,
4913,
968,
790,
281,
1691,
617,
598,
326,
2360,
347,
703,
574,
3982,
767,
3858,
342,
617,
15,
9240,
3858,
497,
512,
987,
1128,
2858,
1996,
617,
3392,
369,
1119,
281,
320,
11306,
3206,
275,
512,
326,
369,
1469,
327,
275,
326,
629,
273,
253,
1533,
15,
1500,
5972,
13,
352,
4455,
13,
574,
6518,
253,
4913,
968,
790,
275,
10329,
789,
690,
3618,
4321,
285,
369,
5506,
323,
30013,
3129,
11625,
285,
42154,
1146,
23846,
275,
2810,
18326,
15,
733,
369,
703,
665,
574,
2668,
253,
7802,
273,
6505,
281,
253,
8576,
327,
253,
15444,
1388,
15,
380,
9749,
273,
512,
253,
5014,
273,
253,
11484,
4817,
745,
347,
581,
273,
1110,
23293,
16503,
326,
5108,
4536,
15,
380,
7345,
5544,
344,
574,
1929,
824,
247,
2181,
5108,
1078,
15,
3032,
1941,
387,
253,
275,
4557,
7369,
275,
247,
11844,
273,
29056,
324,
2254,
459,
15,
380,
958,
326,
247,
29086,
5253,
574,
644,
22007,
745,
247,
2829,
285,
38737,
407,
7343,
326,
1072,
2360,
17755,
642,
4116,
15,
187,
187,
8,
16830,
13,
6827,
2325,
373,
4379,
13,
368,
651,
320,
6110,
281,
871,
326,
2892,
1537,
452,
6015,
3139,
15,
1422,
497,
5103,
387,
432,
247,
502,
1765,
273,
268,
1301,
284,
10583,
13,
285,
1996,
253,
10692,
6789,
5972,
5767,
29655,
968,
3597,
281,
823,
14537,
281,
634,
8574,
5500,
15,
309,
2096,
703,
310,
2686,
247,
4936,
33475,
390,
1270,
14,
10633,
336,
273,
253,
3236,
6424,
7345,
13,
285,
1078,
253,
6347,
3645,
3660,
703,
369,
247,
1262,
2113,
273,
18985,
34780,
15,
2064,
434,
849,
27936,
9852,
3260,
273,
617,
13,
273,
2282,
15,
1244,
634,
4370,
7964,
31521,
1272,
273,
617,
285,
2335,
8959,
2250,
15,
8079,
359,
1024,
871,
326,
352,
369,
703,
665,
7349,
742,
1711,
29222,
15,
187,
187,
8,
1231,
1024,
452,
281,
1908,
271,
1014,
625,
46189,
1894,
15,
380,
730,
451,
26604,
7345,
369,
36123,
1025,
407,
4130,
275,
253,
1659,
13,
533,
352,
3133,
954,
14051,
327,
253,
1941,
326,
352,
369,
253,
7345,
665,
369,
5506,
323,
6393,
13268,
434,
2471,
13,
2167,
387,
253,
673,
642,
581,
651,
452,
6566,
352,
15,
754,
574,
4618,
8249,
6284,
13,
285,
6485,
3640,
273,
2963,
10047,
285,
858,
45200,
789,
275,
5565,
10537,
15,
733,
556,
2668,
21116,
1107,
1078,
253,
5441,
452,
2489,
1929,
15,
7214,
13651,
30256,
13,
247,
2143,
14889,
387,
253,
673,
13,
3407,
1907,
5697,
2464,
187,
187,
8,
795,
25000,
13268,
858,
417,
3150,
10748,
8291,
686,
15212,
308,
1135,
566,
23727,
15,
686,
795,
1147,
1364,
452,
644,
581,
273,
441,
3333,
686,
1500,
2546,
27,
686,
18412,
352,
253,
7345,
665,
1119,
562,
752,
6393,
369,
2509,
5554,
187,
187,
8,
2302,
15,
380,
7345,
574,
417,
13282,
15,
1292,
11853,
574,
15,
5863,
7357,
840,
703,
574,
644,
4336,
5547,
15,
380,
29066,
17747,
574,
4307,
342,
617,
347,
9355,
15,
380,
1491,
703,
4817,
281,
779,
369,
13241,
285,
344,
1904,
626,
8968,
326,
352,
369,
7194,
5017,
326,
1904,
626,
2647,
1128,
2004,
352,
574,
644,
1160,
281,
3590,
1774,
15,
1893,
14,
8890,
29066,
5827,
285,
20196,
534,
344,
4817,
281,
617,
13,
703,
38597,
8549,
327,
617,
1897,
745,
275,
4693,
13,
20090,
272,
7997,
347,
281,
672,
285,
835,
15,
11628,
6393,
434,
18733,
275,
3667,
290,
434,
4913,
369,
581,
13,
309,
2868,
1128,
395,
253,
7993,
9251,
23957,
275,
611,
13843,
1299,
33892,
369,
1529,
15,
844,
6311,
247,
1175,
2968,
432,
841,
12225,
285,
253,
5884,
6338,
275,
2176,
4443,
515,
447,
7514,
15,
187,
187,
8,
1989,
512,
326,
434,
275,
253,
2469,
13,
6827,
2325,
373,
4379,
13,
1048,
13,
1048,
275,
253,
2469,
2464,
187,
187,
49354,
367,
2804,
12594,
260,
49527,
285,
8423,
2335,
689,
15,
686,
1989,
2892,
24510,
3139,
13,
6827,
2325,
373,
4379,
15,
17814,
33772,
326,
19473,
390,
1996,
15,
329,
13787,
4102,
8460,
264,
275,
40776,
371,
333,
15,
6491,
665,
3260,
670,
352,
873,
1841,
598,
969,
15,
11243,
326,
434,
2139,
5767,
29655,
968,
4895,
15,
35110,
17197,
14,
30345,
497,
908,
969,
15,
7743,
12225,
2335,
1659,
15,
7243,
625,
2583,
3395,
1534,
1128,
2811,
352,
2210,
432,
13,
835,
352,
2427,
281,
15,
2305,
17453,
1060,
369,
1925,
275,
15,
1244,
840,
776,
1711,
3331,
2325,
373,
4379,
2210,
2112,
285,
3053,
4933,
479,
690,
1077,
4722,
1491,
15,
733,
14662,
275,
342,
752,
359,
574,
2168,
13282,
15,
17720,
38811,
13,
1146,
873,
598,
275,
30513,
15,
329,
2852,
1146,
5480,
281,
320,
6537,
285,
1408,
407,
581,
1798,
3569,
4677,
275,
436,
2586,
15,
329,
637,
342,
247,
2176,
12681,
285,
2403,
625,
28472,
285,
18409,
1046,
1388,
15,
380,
11204,
1435,
308,
4662,
275,
2250,
2378,
969,
15,
3083,
273,
6495,
17712,
414,
1128,
45,
1189,
273,
20000,
15,
3105,
47281,
1204,
1128,
1368,
642,
2,
3771,
1633,
326,
4453,
751,
47281,
1204,
15,
20000,
323,
512,
1128,
395,
4832,
23267,
281,
1110,
665,
29406,
2464,
187,
187,
8,
4045,
368,
1599,
352,
434,
1335,
1469,
327,
5554,
308,
1135,
566,
434,
2927,
5485,
4618,
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] | grandmother was a Parkinson. Some things I learnt from her—
'The girl known as Mary Jordan was in our service. She had connections in the Navy—her mother was Austrian and so she herself spoke German fluently.
'As you may know, and as your husband certainly knows already, there are certain documents which will shortly be released for publication.
'The present trend of political thinking is that hush-hush, necessary as it is at certain times, should not be preserved indefinitely. There are things in the records that should be made known as a definite part of our country's past history.
'Three or four volumes are due to be published within the next couple of years authenticated by documentary evidence.
'What went on in the neighbourhood of Swallow's Nest (that was the name of your present house at that time) will certainly be included.
'There were leakages—as always there are leakages in times of war, or preceding a probable outbreak of war.
'There were politicians who had prestige and who were thought of very highly. There were one or two leading journalists who had enormous influence and used it unwisely. There were men even before the First World War who were intriguing against their own country. After that war there were young men who graduated from universities and who were fervent believers and often active members of the Communist Party without anyone knowing of that fact. And even more dangerous, Fascism was coming into favour with a full progressive programme of eventual union with Hitler, posing as a Lover of Peace and thereby bringing about a quick end to the war.
'And so on. A Continuous Behind the Scenes Picture. It has happened before in history. Doubtless it will always happen: a Fifth Column that is both active and dangerous, run by those who believed in it—as well as those who sought financial gain, those who aimed at eventual power being placed in their hands in the future. Some of this will make interesting reading. How often has the same phrase been uttered in all good faith: Old B.? A traitor? Nonsense. Last man in the world! Absolutely trustworthy!
'The complete confidence trick. The old, old story. Always on the same lines.
'In the commercial world, in the Services, in political life. Always a man with an honest face—a fellow you can't help liking and trusting. Beyond suspicion. "The last man in the world". Etc., etc., etc. Someone who's a natural for the job, like the man who can sell you a gold brick outside the Ritz.
'Your present village, Mrs Beresford, became the headquarters of a certain group just before the First World War. It was such a nice old-world village—nice people had always lived there—all patriotic, doing different kinds of war work. A good naval harbour—a good-looking young Naval commander—came of a good family, father had been an admiral. A good doctor practising there—much loved by all his patients—they enjoyed confiding their troubles to him. Just in general practice—hardly anyone knew that he had had a special training in chemical warfare—in poison-gases.
'And later, before the Second World War, Mr Kane—spelt with a K—lived in a pretty thatched cottage by the harbour and had a particular political creed—not Fascist—oh no! Just Peace before Everything to save the world—a creed rapidly gaining a following on the Continent and in numerous other countries abroad.
'None of that is what you really want to know, Mrs Beresford—but you've got to realize the background first, a very carefully contrived one. That's where Mary Jordan was sent to find out, if she could, just what was going on.
'She was born before my time. I admired the work she had done for us when I heard the story of it—and I would have liked to have known her—she obviously had character and personality.
'Mary was her own Christian name though she was always known as Molly. She did good work. It was a tragedy she should die so young.'
Tuppence had been looking up to the wall at a picture which for some reason looked familiar. It was a mere sketch of a boy's head.
'Is that—surely—'
'Yes,' said Mr Robinson. 'That's the boy Alexander Parkinson. He was only eleven then. He was a grandson of a great-aunt of mine. That's how Molly went to the Parkinsons' in the role of a nursery governess. It seemed a good safe observation post. One wouldn't ever have thought—' he broke off, 'what would come of it.'
'It wasn't—one of the Parkinsons?' asked Tuppence.
'Oh no, my dear. I understand that the Parkinsons were not involved in any way. But there were others—guests and friends—staying in the house that night. The evening in question was the date of a census return. The names of everyone sleeping under that roof had to be entered as well as the usual occupants. One of those names linked up in a significant manner. The daughter of the local doctor about whom I have just told you came down to visit her father as she often did and asked the Parkinsons to put her up that night as she had brought two friends with her. Those friends were all right—but later her father was found to be heavily involved in all that was going on in that part of the world. She herself, it seemed, had helped the Parkinsons in garden work some weeks earlier and was responsible for foxgloves and spinach being planted in close proximity. It was she who had taken the mixture of leaves to the kitchen on the fatal day. The illness of all the participants of the meal passed off as one of those unfortunate mistakes that happen sometimes. The doctor explained he had known such a thing happen before. His evidence at the inquest resulted in a verdict of Misadventure. The fact that a cocktail glass had been swept off a table and smashed by accident that same night attracted no attention.
'Perhaps, Mrs Beresford, you would be interested to know that history might have repeated itself. You were shot at from a clump of pampas grass, and later the lady calling herself Miss Mullins tried to add poison to your coffee cup. I understand she is actually a granddaughter or great-niece of the original criminal doctor, and before the Second World War she was a disciple of Jonathan Kane. That's how Crispin knew of her, of course. And your dog definitely disapproved of her and took prompt action. Indeed we now know that it was she who coshed old Isaac.
'We now have to consider an even more sinister character. The genial kindly doctor was idolized by everyone in the place, but it seems most probable on the evidence that it was the doctor who was responsible for Mary Jordan's death, though at the time no one would have believed it. He had wide scientific interests, and expert knowledge of poisons and did pioneering work in bacteriology. It has taken sixty years before the facts have become known. Only Alexander Parkinson, a schoolboy at the time, began having ideas.'
' _Mary Jordan did not die naturally,_ ' quoted Tuppence softly. ' _It must have been one of us._ ' She asked: 'Was it the doctor who found out what Mary was doing?'
'No. The doctor had not suspected. But somebody had. Up till then she had been completely successful. The Naval commander had worked with her as planned. The information she passed to him was genuine and he didn't realize that it was mainly stuff that didn't matter—though it had been made to sound important. So-called Naval plans and secrets which he passed to her, she duly delivered on her days off in London, obeying instructions as to when and where. Queen Mary's Garden in Regent's Park was one, I believe—and the Peter Pan statue in Kensington Gardens was another. We learned a good deal from these meetings and the minor officials in certain embassies concerned.
'But all that's in the past, Mrs Beresford, long, long in the past.'
Colonel Pikeaway coughed and suddenly took over. 'But history repeats itself, Mrs Beresford. Everyone learns that sooner or later. A nucleus recently reformed in Hollowquay. People who knew about it set things up again. Perhaps that's why Miss Mullins returned. Certain hiding-places were used again. Secret meetings took place. Once more money became significant—where it came from, where it went to. Mr Robinson here was called in. And then our old friend Beresford came along and started giving me some very interesting information. It fitted in with what we had already suspected. Background scenery, being set up in anticipation. A future being prepared to be controlled and run by one particular political figure in this country. A man with a certain reputation and making more converts and followers every day. The Confidence Trick in action once again. Man of Great Integrity—Lover of Peace. Not Fascism—oh no! Just something that looks like Fascism. Peace for all—and financial rewards to those who cooperate.'
'Do you mean it's still going on?' Tuppence's eyes opened wide.
'Well, we know more or less all we want and need to know now. And that's partly because of what you two have contributed—the operation of a surgical nature on a rocking-horse was particularly informative—'
'Mathilde!' exclaimed Tuppence. 'I _am_ glad! I can hardly |
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] | Find the second derivative of x(t) wrt t.
60*t**3 - 96*t + 4
Let u(g) = 138 + 0 + 207*g - 440*g. Let m(j) = -228*j + 139. Let h(n) = 3*m(n) - 4*u(n). Differentiate h(s) with respect to s.
248
Let l = 136 - 62. Let t = 76 - l. What is the first derivative of 5*c**t + 10*c**2 - 14 - 2*c**2 + 11*c**2 wrt c?
48*c
Let c = 37 - 35. Find the third derivative of -1330*b**5 + 96*b**c + 672*b**5 + 669*b**5 wrt b.
660*b**2
Let h be 0/((6 - -4)*-1). Let z(o) be the second derivative of -6*o + h - 11/6*o**3 - 11*o**2. What is the first derivative of z(r) wrt r?
-11
Let j = -69 + 74. Suppose 5*o + 25 = j*i, 0 = 8*i - 3*i + 3*o - 1. Find the third derivative of 2*x**6 + 23*x**6 - 10*x**2 - 4*x**2 + x**i wrt x.
3000*x**3
Let v(u) be the first derivative of 47 - 41*u - 1/2*u**2 - 23*u**3. Find the second derivative of v(j) wrt j.
-138
Let p(v) = 5862*v**2 + 3614. Let z(o) = 43966*o**2 + 27113. Let r(a) = -38*p(a) + 5*z(a). Find the first derivative of r(d) wrt d.
-5852*d
Let h(g) be the first derivative of 103*g**6/30 + 15*g**3/2 - 86*g + 11. Let b(a) be the first derivative of h(a). What is the second derivative of b(n) wrt n?
1236*n**2
Suppose 32*d = 31*d. Suppose n + 1 - 19 = d. What is the second derivative of -237*f**4 + 222*f**4 + f - n*f wrt f?
-180*f**2
Suppose -10*p = -19*p + 27. Find the third derivative of 17*o**5 - 15*o**3 - 14*o**2 + 10*o**p + 7*o**3 wrt o.
1020*o**2 + 12
Suppose 0 = v - 2*k - 6, -4*v - k - 4*k = -24. Find the third derivative of 4385*f - 4385*f - v - 3*f**2 - 22*f**5 wrt f.
-1320*f**2
Let r(o) be the first derivative of 4066*o**3/3 - 3*o**2 + 222*o + 7135. What is the second derivative of r(t) wrt t?
8132
Let n(a) be the first derivative of 5063*a**3/3 + 3179*a + 589. What is the derivative of n(w) wrt w?
10126*w
Let x(o) = -o**2 + 11*o + 7. Let y be x(12). Let j be 22/6 + y/((-30)/(-4)). Find the third derivative of 20*k**j + 17*k**3 - 25*k**5 - 37*k**3 - 34*k**2 wrt k.
-1500*k**2
Find the second derivative of -29*p**3 + 45*p**3 - 16*p**3 - 544*p - 253*p**4 - 1908*p wrt p.
-3036*p**2
Let m(z) be the first derivative of -2*z**5/5 - 53*z**4/4 + 10*z**3/3 - 1008*z**2 + 468. Find the second derivative of m(v) wrt v.
-24*v**2 - 318*v + 20
Suppose 0 = -3*r - 3*w, -2*w + 3*w = -5*r. What is the second derivative of 72*g**2 + 34 - 8*g + r*g + 6*g + 0*g wrt g?
144
Let h(v) be the second derivative of -7/2*v**2 - 85*v + 0*v**3 - 2 - 17/3*v**4. Differentiate h(t) wrt t.
-136*t
Let a = 30 + -28. Suppose -7*w + a*w = -5*o - 545, -4*w + 2*o = -438. Find the second derivative of -2 - w*z**4 + 11*z + 2 + 119*z**4 wrt z.
108*z**2
Let l(z) = -33*z**4 - 15*z**2 + 122*z - 54. Let u(p) = -16*p**4 - 6*p**2 + 60*p - 27. Let h(f) = 5*l(f) - 9*u(f). Find the second derivative of h(r) wrt r.
-252*r**2 - 42
What is the third derivative of -646*x**2 + 524*x**2 - 1439*x**2 + 1155*x**5 + 215*x**5 wrt x?
82200*x**2
Let z(r) be the first derivative of -6131*r**5/5 - 5622*r + 4489. Differentiate z(f) with respect to f.
-24524*f**3
Let g be (-1*4/14)/(1/(-49)). Suppose -g = 6*v - 13*v. Differentiate -73*h**2 + 37*h**v + 41 - 39*h**3 + 36*h**2 wrt h.
-117*h**2
Let l(b) be the third derivative of -152*b**7/105 - 131*b**5/60 - b**3 - 691*b**2. Find the third derivative of l(h) wrt h.
-7296*h
Suppose 4*l = y + 27 - 8, 12 = -4*y. Suppose -26 = -l*r - 18. Find the third derivative of 30 + 12*t**r - 7*t**6 - 30 wrt t.
-840*t**3
Let f(i) = -i. Let b(t) = -8*t + 8. Suppose -2*g + 9 = -g + 3*n, 2*g = -4*n + 14. Let q(j) = g*f(j) + b(j). Differentiate q(o) wrt o.
-11
Let p(c) be the third derivative of -989*c**5/60 - c**4/8 - 103*c**3/3 + 1478*c**2. What is the second derivative of p(w) wrt w?
-1978
Let m be -29*2/(-10) + (-117)/(-585). Find the third derivative of -250*q**m - 5*q + 5*q + 290*q**6 + 141*q**2 wrt q.
4800*q**3
Let l = 721 + -595. What is the derivative of -2184*y + 4440*y + l - 2217*y wrt y?
39
Let l(s) = 25*s**2 - 18*s - 1770. Let x(p) = -24*p**2 + 19*p + 1767. Let b(v) = -7*l(v) - 6*x(v). Differentiate b(r) wrt r.
-62*r + 12
Let s(c) be the first derivative of -7/2*c**2 + 11 + 0*c - 2/3*c**3. Let n(g) = g**2. Let x(q) = -3*n(q) + s(q). Find the second derivative of x(d) wrt d.
-10
Let n(x) be the second derivative of -x - 13/4*x**4 - 4 + 0*x**2 - 21/10*x**5 + 0*x**3. What is the third derivative of n(f) wrt f?
-252
Let l(v) be the first derivative of 15*v**5 + 0*v**3 + 120 + 0*v**4 - 39/2*v**2 + 0*v. Find the second derivative of l(m) wrt m.
900*m**2
Let l(r) be the first |
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] | showed aneuploid, the other 4 specimens showed polyploid. Namely, intratumoral heterogeneity was observed in one case. Ther was no relationship between intratumoral heterogeneity tumor size or differentiation. Most lung adenocarcinomas showed DNA stability. Fine needle aspiration specimens obtained from one area of lung adenocarcinoma represent the DNA contents of the entire tumor.Excelにはもともと、クラッシュしたデータを復旧するための自動保存機能が備わっている。Office 2003以前であれば「ツール」−「オプション」から自動保存機能を有効にしておくことで、万一Excelが強制終了するような事態に遭遇しても、ファイルを回復できるのだ。
これはこれで便利な機能だが、基本的に1世代分のバックアップしか取れないため、1世代以上前に消した内容をもう1度確認したい、といった用途には対応できない。こうした場合に便利なのが、今回紹介する「SS自動保存」だ。
Excelのアドインとして利用するこのSS自動保存は、指定した間隔で世代バックアップを自動的に行ってくれる。設定できる項目は、バックアップの間隔(1〜59分)、履歴数(最大で99個)、保存先フォルダ、の3種類だ。初期設定では、10分間隔で3世代までのExcelファイルをバックアップしてくれるようになっている。
アプリケーションが強制終了した場合はもちろんのこと、例えば数分前の内容をもう一度参照したい場合に、バックアップを保存しているフォルダを見れば、以前のファイルがそのままの形で残っている可能性があるわけだ。
単純に等間隔でバックアップを取るだけではなく、しばらく編集が行われなかった場合はバックアップをストップしてくれるなど、細かい操作性にも配慮されている。「こんなこともあろうかと」を実現する便利なアドインであり、手軽に追加できるメリットもあるので、ぜひとも導入しておきたい。
本日のレシピ アドイン名 対応Office 利用料 作者 SS自動保存 Office 2002／2003（編集部で試したところ、Office 2007では利用できなかった） 無料 こけも（.com/fort）氏
Copyright © ITmedia, Inc. All Rights Reserved.Related Articles
He told the BBC: "English language is something that we're pushing very strongly.
"Two things about the English language: You need it to get a job; secondly it brings a community together.
"Public money should be spent encouraging people to speak and learn English. Whenever I raise that with my residents they all agree with that."
Cutting the newspapers, which include publications in Urdu, Gujarati, Bengali and Hindi, would also save the council money, which could be spent on projects to improve residents’ English instead.
Sir Robin added: "Our view is that public money should be spent on building resilience in our community by promoting the use of the English language.
"At a time when the Government is cutting money for English classes as a second language, we are investing in this because we know it will help our residents find employment and bring the community closer together."
Priyonath Singh, 76, of Newham, said: "It's appalling. It's a drastic measure. If you remove the newspapers, my mental age will be reduced completely.”There is a shield gun which is surrounded by the enemies. So you should destroy all the enemies by using that sheildgun. You may attacked by bullets from enemies then you will be lose your life so you will be destroyed by your enemies.Once completed one mission then next level will be there.Use mouse to play this game
Random Games
Match pairs in this cool memory game.The aim of the game is to find all the matching pairs from the set of cards.Click on a card and it will turn face up, then attempt to find its match by selecting another card. If the value of the two cards matches then a pair has been found an [...]
Manage the Cute Pet Restaurant. Serve the food to pets quickly to run the restaurant more successful. Be fast when you are serving or the customer will leave the shop with a bad reputation. Complete the daily goals before the time runs out.Use mouse to play.
Click your mouse to accelerate in this simple but fun racing game! Race your truck and avoid all obstacles in the shortest time possible! Be careful, every level is different and the moving obstacles will make your life that little bit harder soon enough! The longer you hold the [...]
Tourist attractions are designed to be difficult to leave. Do your best to get this poor couple out! In this top-down, isometric action puzzle game, it's your job to use your wits and the teamwork of the tourists to escape the tourist trap. Use bombs to open spaces, but don't blo [...]
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In War Elephant, your goal is to face hordes of the world's most vicious warriors as you lead your army to glory in your quest for the legendary axe! Upgrade your units! Call for reinforcements during battle! Buy as many as it takes to win this awesome game and remember as long a [...]Red Quill Books
Red Quill Books was founded in 2009 by a group of scholars led by professor George S. Rigakos, based out of Carleton University in Ottawa, Canada. The press, however, has no formal association with Carleton University. The primary mission of the press is to create a venue for reanimating classic, radical texts through comic book or manga formats aimed at a new generation of student, faculty and general readers. Red Quill Books has also sought to develop as sizable catalogue of critical academic books. A founding principle of the press is to funnel a portion of its revenues toward student scholarships in order to support future critical research.
Early notoriety
A year after its launch, Red Quill Books earned some early notoriety for its four-part Communist Manifesto Illustrated series which elicited attention in North America. Red Quill Books has followed this with the release of Capital in Manga which is the English translation of the Manga de Dokuha version produced by East Press, and The Last Days of Che Guevara, derived from the Italian comic entitled Que Viva El Che Guevara.
References
Notable releases
Mark, Karl and Frederik Engels. Edited by: George S. Rigakos. Illustrated by Victor Serra. (2010) The Communist Manifesto Illustrated. Chapter One – Historical Materialism. Ottawa: Red Quill Books
Marx, Karl. Edited by: Variety Artworks. Translated by: Guy Yasko. Capital in Manga! Ottawa: Red Quill Books
Rizzo, Marco and Lelio Bonaccorso (Illustrator). (2014) The Last Days of Che Guevara: A Graphic Novel Ottawa: Red Quill Books
External links
Red Quill Books
Che Guevara Biography Illustrated
Category:Comic book publishing companies of Canada
Category:Companies based in Ottawa[NYPD:]
That’s good but the transit authority says that you cannot play down here without a PERMIT!
[Andrew Kalleen:]
No it doesn’t – it says
[NYPD:]
Yes it does.
[Andrew Kalleen:]
No, no it doesn’t
[NYPD:]
It does. I’m not going to argue with you.
[Andrew Kalleen:]
We are arguing.
[NYPD:]
No we aren’t arguing.
[Andrew Kalleen:]
We’ve been arguing the whole time.
[NYPD:]
I’m asking you to put your guitar away.
[Andrew Kalleen:]Source: LYBIO.net
And I’m saying, no.
[NYPD:]
Then you’re gonna be arrested.
[Andrew Kalleen:]
That’s illegal.
[NYPD:]
No (inaudible)
[ |
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] | left(z_1,A_1\cap A^{\ast}_1,D_{1,N\delta_0}\right)+\widetilde{\omega}\Big(z^{'},A_{2,\delta}\times\cdots \times A_{N,\delta},
\widehat{\X}\left(A_2,\ldots,A_N;D_2,\ldots,D_N\right) \Big)\\
\leq
\frac{ \sum\limits_{j=1}^N\widetilde{\omega}( z^0_j,
A_{j} , D_j)+\delta_0 }{1-N\delta_0}<1 .\end{gathered}$$ for $z=(z_1,z^{'})\in U\times V$ and $0<\delta\leq\delta_0 .$ Consequently, we are able to apply Lemma \[limit\_lem\].
We complete the proof as follows. An immediate consequence of Lemma \[limit\_lem\] and formula (\[eq8.1.10\]) is that $\hat{f}\in\mathcal{O}\left(\widehat{X},Z \right).$ Moreover, by (\[eq8.1.2\])–(\[eq8.1.3\]) and (\[eq8.1.7\])–(\[eq8.1.10\]), and using the fact that $D_{1,N\delta}\nearrow D_1$ as $\delta\searrow 0$ (see (\[eq8.1.1\])), we conclude that $\hat{f}=f$ on the following set $$(A_1\cap A^{\ast}_1)\times \X\left(A_2\cap A^{\ast}_2,\ldots,
A_N\cap A^{\ast}_N; D_2,\ldots,D_N \right) \bigcup
D_1\times (A_2\cap A^{\ast}_2)\times \cdots\times
(A_N\cap A^{\ast}_N ) .$$ Since this set is equal to $X\cap
X^{\ast}, $ it follows from Theorem \[unique3\] that the mapping $\hat{f}$ provided by formula (\[eq8.1.10\]) possesses all the desired properties. This completes induction (II) for $k=k_0-1.$ Hence, the proofs of induction (II), induction (I) and then the first part of the theorem are finished. $\square$
Proof of the estimate in Theorem A
----------------------------------
Following the work in [@pn1] we divide this part into two steps.
[**Step 1:**]{} [*Proof of the inequality $\vert \hat{f}\vert_{\widehat{X}}\leq\vert f\vert_X.$*]{}
[*Proof of Step 1.*]{} In order to reach a contradiction assume that there is a point $z^0\in\widehat{X}$ such that $\vert\hat{f}(z^0)\vert>\vert
f\vert_X.$ Put $\alpha:=\hat{f}(z^0)$ and consider the function $$\label{eq8.2.1}
g(z):=\frac{1}{f(z)-\alpha},\qquad z\in X.$$ Using the above assumption, we clearly have that $g\in\mathcal{O}_s(X,\C).$ Hence by Subsection 8.1, there is exactly one function $\hat{g}\in\mathcal{O}(\widehat{X},\C)$ with $\hat{g}=g$ on $X.$ Therefore, by (\[eq8.2.1\]) we have on $X:$ $g(f-\alpha)\equiv 1.$ Thus $\hat{g}(\hat{f}-\alpha)\equiv 1$ on $\widehat{X}.$ In particular, $$0=\hat{g}(z^0 )(\hat{f}(z^0)-\alpha)= 1,$$ which is a contradiction. Hence the inequality $\vert \hat{f}\vert_{\widehat{X}}\leq\vert f\vert_X$ is proved. Thus Step 1 is complete. $\square$
[**Step 2:**]{} [*Proof of the inequality $$\label{eq8.2.2}
\vert \hat{f}(z)\vert\leq\vert f\vert_A^{1-\omega(z)}\vert f\vert_X^{\omega(z)}
.$$*]{} [*Proof of Step 2.*]{} We prove (\[eq8.2.2\]) by induction on $N.$ When $N=1,$ then applying Theorem \[two-constant\] to the plurisubharmonic function $z\in D_1\mapsto \log\vert \hat{f}(z)\vert,$ (\[eq8.2.2\]) follows. Suppose that (\[eq8.2.2\]) is true for $N-1.$ We would like to prove it for $N.$ Fix an arbitrary point $z^0=\left(z^0_1,\ldots,z^0_N\right)\in\widehat{X}.$ Let $$\label{eq8.2.3}
\delta:=\sum\limits_{j=2}^N\widetilde{\omega}(z^0_j,A_j,D_j).$$
For any $a_1\in A_1\cap A^{\ast}_1,$ we apply the hypothesis of induction to the function $\hat{f}_{a_1}$ and obtain the estimate $$\label{eq8.2.4}
\vert \hat{f}_{a_1}\left(z^0_2,\ldots,z^0_N\right)\vert\leq\vert f\vert_A^{1-\delta}\vert f\vert_X^{\delta}
.$$ In virtue of (\[eq8.1.8\])–(\[eq8.1.10\]), we obtain that $$\hat{f}_{a_1}\left(z^0_2,\ldots,z^0_N\right)=\hat{f}\left(a_1,z^0_2,\ldots,z^0_N\right),\qquad
a_1\in A_1\cap A^{\ast}_1.$$ This, combined with (\[eq8.2.4\]), implies that $$\label{eq8.2.5}
\left\vert \hat{f} \left(\cdot,z^0_2,\ldots,z^0_N\right)\right\vert_{A_1\cap A^{\ast}_1}\leq\vert f\vert_A^{1-\delta}\vert f\vert_X^{\delta}
.$$ On the other hand, $$\label{eq8.2.6}
\left\vert \hat{f} \left(\cdot,z^0_2,\ldots,z^0_N\right)\right\vert_{D_{1,\delta}}
\leq\vert \hat{f}\vert_{\widehat{X}}\leq\vert f\vert_X,$$ where the latter estimate follows from Step 1.
Applying Theorem \[two-constant\] to the function $\left.\log{\left\vert \hat{f} \left(\cdot,z^0_2,\ldots,z^0_N\right)\right\vert}\right|_{D_{1,\delta}},$ and taking (\[eq8.2.5\]) and (\[eq8.2.6\]) into account, we obtain $$\begin{aligned}
\vert\hat{f}(z^0)\vert&\leq&
\left\vert \hat{f} \left(\cdot,z^0_2,\ldots,z^0_N\right)\right\vert_{A_1\cap
A^{\ast}_1}^{1- \widetilde{\omega}(z^0_1,A_1\cap A^{\ast}_1, D_{1,\delta})}
\left\vert \hat{f}
\left(\cdot,z^0_2,\ldots,z^0_N\right)\right\vert_{D_{1,\delta}}^{ \widetilde{\omega}(z^0_1,A_1\cap A^{\ast}_1,
D_{1,\delta})}\\
&=& \vert f\vert_A^{1-\omega(z^0)}\vert f\vert_X^{\omega(z^0)}, \end{aligned}$$ where the equality follows from (\[eq8.2.3\]) and the identity $ \widetilde{\omega}(z^0_1,A_1\cap A^{\ast}_1, D_{1,\delta})=\frac{ \widetilde{\omega}(z^0_1,A_1\cap A^{\ast}_1,
D_{1})}{1-\delta}$ (by Part 4) of Proposition \[prop3.5\]). Hence estimate (\[eq8.2.2\]) for the point $z^0$ is proved. Since $z_0$ is an arbitrary point in $\widehat{X},$ (\[eq8.2.2\]) follows, and the proof of the estimate in Theorem A is thereby finished. $\square$
Combining the result of Subsections 7.1 and 7.2, Theorem A follows. $\square$
Finally, we conclude the article by some remarks and open questions.
1\. Recent development in the theory of separately analytic mappings is characterized by cross theorems with pluripolar singularities and boundary cross theorems. The most general results are contained in some articles of Jarnicki and Pflug (see [@jp2; @jp3; @jp4]) and in recent works |
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] | r_+ \Xi}{\left(r_+^2+a^2\right)V}\partial_{\phi}\biggr)\,,\nonumber \\
&& {\bm{m}}^{\mu}\partial_{\mu}=\frac{\sqrt{\Delta_{\theta}}}{\sqrt{2}\left(r_++i a \cos\theta\right)}\biggl(\partial_{\theta}+i\frac{\Xi \,\Sigma_+^2}{\left(r_+^2+a^2\right)\sin\theta\Delta_{\theta}}\partial_{\phi}\biggr)\,.
$$ The NP spin coefficients can be obtained from this tetrad and . The non-vanishing ones are $$\begin{aligned}
{3}\label{NHEKAdS:spinCoef}
\alpha=&-\frac{r_+\cos\theta\bigl(\ell^2+a^2\left(1-2\cos^2\theta\right)\bigr)-ia\bigl(\ell^2\left(2-\cos^2\theta\right)-a^2\cos^2\theta\bigr)}{2\sqrt{2}\,\ell^2\left(r_+\!-i a\cos\theta\right)^2\sin\theta\sqrt{\Delta_{\theta}}}\,, \qquad
\gamma=\frac{r}{2\Sigma_+^2}\,,\nonumber \\
\beta=&\frac{\cos\theta\bigl(\ell^2+a^2(1-2\cos^2\theta)\bigr)}{2\sqrt{2}\,\ell^2\left(r_+\!+i a\cos\theta\right)\sin\theta\sqrt{\Delta_{\theta}}}\,, \qquad
\pi=\frac{i\,a\sin\theta\sqrt{\Delta_{\theta}}}{\sqrt{2}\left(r_+\!-i a \cos\theta\right)^2}\,, \qquad
\tau= -\frac{i \,a\sin\theta\sqrt{\Delta_{\theta}}}{\sqrt{2}\Sigma_+^2}\,.\end{aligned}$$ NHEK-AdS is a Petrov type D geometry since the only non-vanishing complex Weyl scalar is $$\label{NHEKAdS:Psi2}
\Psi_2 =-\frac{(a^2+r_+^2)^2}{r_+(a^2+3r_+^2)(r_+-i a\cos\theta)^3}\,.$$ Inserting the NP spin coefficients and the directional derivatives associated with the basis into the Teukolsky equations and , we get the Teukolsky master equation for spin $s={\pm 2, \pm 1, \pm 3/2, \pm 1/2}$ in the NHEK-AdS background, $$\begin{aligned}
{2}\label{NHgeometry_master eq}
&\frac{V}{1+r^2}\,\partial_t^{\,2}\Psi^{(s)}
-\frac{4a\,r\,r_+\,\Xi}{\left(1+r^2\right)\left(r_+^2+a^2\right)}\,\partial_t\partial_{\phi}\Psi^{(s)}+\frac{\Xi^2}{{\left(r_+^2+a^2\right)}^2}\Biggl[\frac{4a^2r^2r_+^2}{V\left(1+r^2\right)}\nonumber\\
&-\frac{\Sigma_+^{\,4}}{\Delta_{\theta}\sin^2\theta}\Biggr]\partial_{\phi}^{\,2}\Psi^{(s)}-V\left(1+r^2\right)^{-s}\partial_r\left[ \left(1+r^2\right)^{s+1}\,\partial_r\Psi^{(s)}\right]\nonumber\\
&-\frac{1}{\sin\theta}\,\partial_{\theta}\Bigl(\sin\theta\Delta_{\theta}\,\partial_{\theta}\Psi^{(s)}\Bigr)-2s\,\frac{V\,r}{1+r^2}\,\partial_t\Psi^{(s)}-2s\,\frac{\Xi}{r_+^2+a^2}\Biggl[\frac{2a\,r_+}{1+r^2}\nonumber\\
&+i\cos\theta\left(\frac{a^2\left(r_+^2+\ell^2\right)}{\ell^2\Delta_{\theta}}+\frac{r_+^2+a^2}{\sin^2\theta}\right)\Biggr]\partial_{\phi}\Psi^{(s)}+\Biggl\{\left(16\,s^8-120\,s^6+273\,s^4\right)\frac{\Sigma_+^{\,2}}{18\ell^2}\nonumber\\
&+s^2\left[\frac{\Xi}{\sin^2\theta}-\frac{\Xi}{\Delta_{\theta}}-\frac{\left(277\,r_+^2+205\,a^2\cos^2\theta\right)}{18\ell^2}\right]-sV\Biggr\}\Psi^{(s)}=4\pi \mathcal{T}_{(s)}\,.\end{aligned}$$ The relation between the master fields $\Psi^{(s)}$ and the perturbed Weyl scalars is given by , with the background $\Psi_2$ defined in , and the master source terms $\mathcal{T}_{(s)}$ are defined via . Setting $s=0$ in this master equation we get the Klein-Gordon equation for a massless scalar field in the NHEK-AdS geometry.
To solve the above master equation we introduce the separation constant $\Lambda^{(s)}_{lm}$, and make the separation ansatz $$\label{NHgeometry_separation ansatz}
\Psi^{(s)}=e^{-i\omega t}e^{im\phi}\left(1+r^2\right)^{-s/2}\Phi^{(s)}_{lm\omega}(r)S^{(s)}_{lm}(\theta)\,.$$ The resulting angular equation is (with $a$ given by )
$$\begin{aligned}
\label{NHgeometry_angular master eq}
&\frac{1}{\sin\theta}\,\partial_\theta\left(\!\sin\theta\Delta_{\theta}\partial_\theta\,S^{(s)}_{lm}(\theta)\!\right)+\Biggl[-\left(16\,s^8-120\,s^6+273\,s^4\right)\frac{\Sigma_+^{\,2}}{18\ell^2}+s^2\,\biggl(-\frac{a^2\cos^2\theta\,\Xi}{\ell^2\Delta_{\theta}}-\frac{\Xi}{\sin^2\theta}\nonumber\\
&+\frac{\Xi}{\,\,\,\Delta_{\theta}}+\frac{\left(277\,r_+^2+205\,a^2\cos^2\theta\right)}{18\ell^2}\biggr)-\frac{m\left(m+2s\cos\theta\right)\Xi}{\sin^2\theta}
+\frac{16\,m^2a^4}{\ell^2\left(r_+^2-a^2\right)}+\frac{16m^2a^6\left(a^2+7r_+^2\right)}{V\ell^4{\left(r_+^2-a^2\right)}^2}\Biggr) \nonumber\\
&+\frac{\Xi }{\ell^2 \Delta _{\theta}}\left(\frac{2 a \,m \,r_+^2}{\left(r_+^2-a^2\right)}+s\, a \cos \theta\right)^2+V\biggr(\frac{a^2m^2}{\left(r_+^2-a^2\right)}+\underbrace{s-\frac{7m^2}{4}+\Lambda^{(s)}_{lm}}_{-s^2+{\widetilde{\Lambda}}^{(s)}_{lm}}\biggl) \,\Biggr]S^{(s)}_{lm}(\theta)=0\,.\end{aligned}$$
while the radial equation for $\Phi^{(s)}_{lm\omega}(r)$ reads $$\label{NHgeometry_radial master eq}
\frac{d}{dr}\biggl[\left(1+r^2\right)\frac{d}{dr}\Phi^{(s)}_{lm\omega}(r)\biggr]-\biggl[\mu^2-\frac{\left(\omega+qr\right)^2}{1+r^2}\biggr]\Phi^{(s)}_{lm\omega}(r)=0\,,$$ where $$\label{def:muq}
\mu^2=q^2+s^2+s-\frac{7m^2}{4}+\Lambda^{(s)}_{lm}\equiv q^2+{\widetilde{\Lambda}}^{(s)}_{lm}\,,\qquad q=\frac{2a\,m\,r_+\Xi}{\left(r_+^2+a^2\right)V}-i\,s\,.$$ We have introduced the shifted eigenvalues ${\widetilde{\Lambda}}^{(s)}_{lm}$ which have the advantage of having the symmetry ${\widetilde{\Lambda}}^{(s)}_{lm}={\widetilde{\Lambda}}^{(-s)}_{lm}$ (since $\Lambda _{lm}^{(-s)}=\Lambda _{lm}^{(s)}+2s$) that will be useful later. This follows from the property $S^{(s)}_{lm}(\pi-\theta)=S^{(s)}_{lm}(\theta)$. Moreover, when $\ell \to \infty$ one has $q\to m-i\,s$, in agreement with the asymptotically flat limit result [@Dias:2009ex].
An interesting observation, first made in the |
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] | will be compiled into the assembly, and if you're using a shared bin folder, you shouldn't need to do anything more. If they won't be shared, you'll have to attach to the AssemblyResolve and TypeResolve events in the global application (more on this here).
We eventually scrapped this idea because of security concerns, and ended up going with MEF data contracts but if all of your other assemblies are first party, then this should be quick and easy. Hope this helps.
<%= back_link_to admin_budget_groups_path(@budget) %>
<h2><%= @budget.name %></h2>
<h3><%= t("admin.budget_groups.form.#{action}") %></h3>
5. Seems like every time we have worn non traditional uniforms in the past we have lost. So based on that I would say no. Although if they came out in black helmets, jerseys and pants, that would be really cool.Q:
didReceiveMemoryWarning from UITableView with Images created with url data followed by app termination due to memory pressure
I am setting up a UITableview, and on the side of each cell is an image that is 80x80. The TableView works perfectly when the number of cells is less than 8, but any more than this and sometimes the scroll performance can have a minor delay. With a lot more cells (around 50), the scroll performance is fine as long as you dont make a big swipe down quickly. Also, when there are a lot of cells, if you stay on this view for too long and scroll up and down, the app will receive a memory warning, and then will eventually crash. Any tips for helping to save memory? Some of these images are pretty large (5000 x 1000), or how to clear some memory when didReceiveMemoryWarning is called? I'm using ARC if that is relevant. Here is the code I use to set up the cells:
- (UITableViewCell *)tableView:(UITableView *)tableView cellForRowAtIndexPath:(NSIndexPath *)indexPath
{
CustomTableViewCell *cell = [tableView dequeueReusableCellWithIdentifier:@"ArticleCell"];
if(cell == nil){
cell = [[CustomTableViewCell alloc] initWithStyle:UITableViewCellStyleSubtitle reuseIdentifier:@"ArticleCell"];
}
cell.titleLabel.text = nil;
cell.imageRight.image = nil;
Article *article = [self.articles objectAtIndex:indexPath.row];
[cell.titleLabel setText:article.title];
if(!article.pictureData){
dispatch_async(dispatch_get_global_queue(DISPATCH_QUEUE_PRIORITY_DEFAULT,0), ^{
NSData* data = [NSData dataWithContentsOfURL:[NSURL URLWithString:article.image]];
dispatch_sync(dispatch_get_main_queue(), ^{
article.pictureData = data;
UIImage *img = [[UIImage alloc] initWithData:data];
CGSize imgSize = CGSizeMake(80, 80);
img = [img resizeImage:img newSize:imgSize];
[cell.imageRight setImage:img];
[self.tableView beginUpdates];
[self.tableView reloadRowsAtIndexPaths:[NSArray arrayWithObjects:indexPath, nil] withRowAnimation:UITableViewRowAnimationNone];
[self.tableView endUpdates];
});
});
} else
[cell.imageRight setImage:[UIImage imageWithData:article.pictureData]];
return cell;
}
The point is though that this tableView is loading all of the cells perfectly, and it can make it all the way through even 50+ rows. I just need to clear some memory, I'm just unsure how.
A:
Your cells are set up differently depending on whether the pictureData is available:
If pictureData is not yet available, it will be downloaded & its full resolution data set on the article object; afterwards a smaller thumbnail image is generated and set on cell.imageRight.
However, if the picture has already been downloaded, a full resolution image is created from pictureData and set on the cell's imageRight without resizing it first..
} else
[cell.imageRight setImage:[UIImage imageWithData:article.pictureData]];
This means that as soon as all pictures have been loaded, each time the tableView dequeues a reusable cell it will also set the full res image on cell.imageRight. I suppose this explains the memory issues you are encountering.
My advice would be to add a UIImage *thumbnail property to the articles object, cache the resized image there after it has been generated from the downloaded data and always use this -thumbnail for the cell's imageRight. Additionally, this will reduce the nontrivial system load (both on memory & cpu) caused by re-generating and resizing the images every time the tableView updates a cell.
Another thing: there's actually no need to bother the main thread with the image resize operation, I suspect that's where the hitching comes from when scrolling. It should help to leave that on the global queue and dispatch_async only the table update to the main queue afterwards.
U.S. church attendance is dropping, but Hope Church in Memphis, Tennessee, is packing the pews — or, in Hope’s case, modern theater seats with individual cup holders.
The Evangelical Presbyterian Church affiliate, one of the fastest-growing in the nation, holds four services each weekend to accommodate the nearly 7,000 parishioners who come for the multiethnic community, the coffee kiosks, the mix of contemporary and traditional music, the outreach to non-churchgoers, and the biblically based message.
Hope’s conservative stance on human sexuality — faithfulness in marriage, chastity in singleness, and marriage between one man and one woman — has done little, if anything, to rein in the church’s galloping growth.
“I think what people appreciate, honestly, is do you believe what you say you believe?” said Hope senior pastor Rufus Smith. “If you’re going to be an [LGBTQ] affirming church, be that, and if you’re not, be that, so people will appreciate whatever your position of conscience is. And I think that is what has helped [evangelical] churches not experience a decline because of that particular issue.”
Four years after the Supreme Court legalized same-sex marriage, conservative churches, led by the evangelicals and nondenominationals, still draw enthusiastic crowds each weekend to their megachurches, even as liberal mainline Protestant denominations wilt.
“For evangelicals, being conservative is what has held them to that same level as a share of the population,” said Ryan P. Burge, an assistant professor of political science at Eastern Illinois University who tracks the data.
Yet the future is uncertain as attendance plateaus. Evangelicals made up 22.5% of the U.S. population in 2018, and that share is expected to inch up to only 22.6% by 2030, according to Mr. Burge’s numbers, which are based on the General Social Survey, a trove of sociological data.
A 2016 study led by Wilfrid Laurier University professor David Millard Haskell found that the “recipe for church growth” was conservative theology coupled with worship music featuring drums and guitars, but he said he thinks the growth has hit a wall since then.
He also said cultural upheaval of gender issues and the battles it entails — such as same-sex wedding cakes, public accommodations and transgender athletes — is taking a toll.
“What’s going on in the culture with the greater acceptance of gay marriage will make it harder for churches promoting traditional views,” Mr. Haskell said.
But he added: “If a church stuck with their traditional views and were able to articulate it in a way that met the hearts and minds, the best research shows that keeping to those traditional values will cause your church to grow.”
Religious conservative leaders at the national level see the fight over gender issues as make-or-break.
“The current cultural attack is indeed about our right to live according to our faith and even about what it means to be a man or a woman,” said Mario Diaz, general counsel of Concerned Women for America. “That is why we are engaged there most prominently. When males are entering women’s private spaces and demanding to compete against them in sports, we must speak up.”
‘Culture war is dead’
Blaming same-sex marriage for the decline of Christian churchgoers in America would be too simplistic, religious scholars say, given that the slide can be traced to the turn of the century — the 19th century — and picked up steam during the sexual revolution of the 1960s.
Mainline denominations that flowed with societal changes, such as the Episcopal Church, the Presbyterian Church (USA), the Evangelical Lutheran Church in America, and the United Church of Christ “have all seen dramatic declines in their membership and attendance as they liberalize their teachings on human sexuality,” said Keith Boyette, president of the Wesleyan Covenant Association.
He said the same is true with the United Methodist Church, a mainline denomination grappling with a schism over same-sex marriage that is expected to play out |
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] | gdeventlastseents: details.finding.eventLastSeen
networkinterfaceid: details.resource.instanceDetails.networkInterfaces.networkInterfaceId
privatednsname: details.resource.instanceDetails.networkInterfaces.privateDnsName
privateipaddress: details.resource.instanceDetails.networkInterfaces.privateIpAddress
subnetid: details.resource.instanceDetails.networkInterfaces.subnetId
vpcid: details.resource.instanceDetails.networkInterfaces.vpcId
publicdnsname: details.resource.instanceDetails.networkInterfaces.publicDnsName
publicip: details.resource.instanceDetails.networkInterfaces.publicIp
direction: details.finding.action.networkConnectionAction.connectionDirection
Behavior:EC2/NetworkPortUnusual:
findingid: details.id
arn: details.arn
awsaccountid: details.accountId
awsregion: details.region
resourcetype: details.resource.resourceType
instanceid: details.resource.instanceDetails.instanceId
instancetype: details.resource.instanceDetails.instanceType
launchtime: details.resource.instanceDetails.launchTime
iamprofilearn: details.resource.instanceDetails.iamInstanceProfile.arn
iamprofileid: details.resource.instanceDetails.iamInstanceProfile.id
net: details.resource.instanceDetails.networkInterfaces
tags: details.resource.instanceDetails.tags
state: details.resource.instanceDetails.instanceState
az: details.resource.instanceDetails.availabilityZone
imageid: details.resource.instanceDetails.imageId
imagedesc: details.resource.instanceDetails.imageDescription
detectorid: details.finding.detectorId
sourceipaddress: details.finding.action.networkConnectionAction.localIpDetails.ipAddressV4
destinationipaddress: details.finding.action.networkConnectionAction.remoteIpDetails.ipAddressV4
sourceport: details.finding.action.networkConnectionAction.localPortDetails.port
destinationport: details.finding.action.networkConnectionAction.remotePortDetails.port
proto: details.finding.action.networkConnectionAction.protocol
evidence: details.finding.evidence
miscinfo: details.finding.additionalInfo
platform: details.resource.instanceDetails.platform
gdeventcreatedts: details.createdAt
gdeventupdatedts: details.updatedAt
gdeventfirstseents: details.finding.eventFirstSeen
gdeventlastseents: details.finding.eventLastSeen
networkinterfaceid: details.resource.instanceDetails.networkInterfaces.networkInterfaceId
privatednsname: details.resource.instanceDetails.networkInterfaces.privateDnsName
privateipaddress: details.resource.instanceDetails.networkInterfaces.privateIpAddress
subnetid: details.resource.instanceDetails.networkInterfaces.subnetId
vpcid: details.resource.instanceDetails.networkInterfaces.vpcId
publicdnsname: details.resource.instanceDetails.networkInterfaces.publicDnsName
publicip: details.resource.instanceDetails.networkInterfaces.publicIp
direction: details.finding.action.networkConnectionAction.connectionDirection
Behavior:EC2/TrafficVolumeUnusual:
findingid: details.id
arn: details.arn
awsaccountid: details.accountId
awsregion: details.region
resourcetype: details.resource.resourceType
instanceid: details.resource.instanceDetails.instanceId
instancetype: details.resource.instanceDetails.instanceType
launchtime: details.resource.instanceDetails.launchTime
iamprofilearn: details.resource.instanceDetails.iamInstanceProfile.arn
iamprofileid: details.resource.instanceDetails.iamInstanceProfile.id
net: details.resource.instanceDetails.networkInterfaces
tags: details.resource.instanceDetails.tags
state: details.resource.instanceDetails.instanceState
az: details.resource.instanceDetails.availabilityZone
imageid: details.resource.instanceDetails.imageId
imagedesc: details.resource.instanceDetails.imageDescription
detectorid: details.finding.detectorId
sourceipaddress: details.finding.action.networkConnectionAction.localIpDetails.ipAddressV4
destinationipaddress: details.finding.action.networkConnectionAction.remoteIpDetails.ipAddressV4
sourceport: details.finding.action.networkConnectionAction.localPortDetails.port
destinationport: details.finding.action.networkConnectionAction.remotePortDetails.port
proto: details.finding.action.networkConnectionAction.protocol
evidence: details.finding.evidence
miscinfo: details.finding.additionalInfo
platform: details.resource.instanceDetails.platform
gdeventcreatedts: details.createdAt
gdeventupdatedts: details.updatedAt
gdeventfirstseents: details.finding.eventFirstSeen
gdeventlastseents: details.finding.eventLastSeen
networkinterfaceid: details.resource.instanceDetails.networkInterfaces.networkInterfaceId
privatednsname: details.resource.instanceDetails.networkInterfaces.privateDnsName
privateipaddress: details.resource.instanceDetails.networkInterfaces.privateIpAddress
subnetid: details.resource.instanceDetails.networkInterfaces.subnetId
vpcid: details.resource.instanceDetails.networkInterfaces.vpcId
publicdnsname: details.resource.instanceDetails.networkInterfaces.publicDnsName
publicip: details.resource.instanceDetails.networkInterfaces.publicIp
direction: details.finding.action.networkConnectionAction.connectionDirection
Trojan:EC2/BlackholeTraffic:
findingid: details.id
arn: details.arn
awsaccountid: details.accountId
awsregion: details.region
resourcetype: details.resource.resourceType
instanceid: details.resource.instanceDetails.instanceId
instancetype: details.resource.instanceDetails.instanceType
launchtime: details.resource.instanceDetails.launchTime
iamprofilearn: details.resource.instanceDetails.iamInstanceProfile.arn
iamprofileid: details.resource.instanceDetails.iamInstanceProfile.id
net: details.resource.instanceDetails.networkInterfaces
tags: details.resource.instanceDetails.tags
state: details.resource.instanceDetails.instanceState
az: details.resource.instanceDetails.availabilityZone
imageid: details.resource.instanceDetails.imageId
imagedesc: details.resource.instanceDetails.imageDescription
detectorid: details.finding.detectorId
destinationipaddress: details.finding.action.networkConnectionAction.remoteIpDetails.ipAddressV4
sourceport: details.finding.action.networkConnectionAction.localPortDetails.port
destinationport: details.finding.action.networkConnectionAction.remotePortDetails.port
proto: details.finding.action.networkConnectionAction.protocol
evidence: details.finding.evidence
miscinfo: details.finding.additionalInfo
platform: details.resource.instanceDetails.platform
gdeventcreatedts: details.createdAt
gdeventupdatedts: details.updatedAt
gdeventfirstseents: details.finding.eventFirstSeen
gdeventlastseents: details.finding.eventLastSeen
networkinterfaceid: details.resource.instanceDetails.networkInterfaces.networkInterfaceId
privatednsname: details.resource.instanceDetails.networkInterfaces.privateDnsName
privateipaddress: details.resource.instanceDetails.networkInterfaces.privateIpAddress
subnetid: details.resource.instanceDetails.networkInterfaces.subnetId
vpcid: details.resource.instanceDetails.networkInterfaces.vpcId
publicdnsname: details.resource.instanceDetails.networkInterfaces.publicDnsName
publicip: details.resource.instanceDetails.networkInterfaces.publicIp
direction: details.finding.action.networkConnectionAction.connectionDirection
Trojan:EC2/DropPoint:
findingid: details.id
arn: details.arn
awsaccountid: details.accountId
awsregion: details.region
resourcetype: details.resource.resourceType
instanceid: details.resource.instanceDetails.instanceId
instancetype: details.resource.instanceDetails.instanceType
launchtime: details.resource.instanceDetails.launchTime
iamprofilearn: details.resource.instanceDetails.iamInstanceProfile.arn
iamprofileid: details.resource.instanceDetails.iamInstanceProfile.id
net: details. |
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13
] | be delayed. App. at 24. When it was disclosed in response to a March 3, 1982, oral inquiry that it would take DOJ several months to reach a decision, PLEI filed, on April 30, 1982, an FOIA complaint in the District Court.
3
On July 19, 1982, DOJ filed a motion for summary judgment. Accompanying the motion was the declaration of the Chief of the Freedom of Information Act and Privacy Act Unit within OLP. The declaration (1) released all but three and one-half lines of one of the documents, (2) described the remaining documents, and (3) claimed section 552(b)(2) and (b)(5) exemptions for the undisclosed material. App. at 31-40. On July 29, 1982, PLEI moved for leave to amend its complaint to include documents sought in a separate, later FOIA request, and on August 16, 1982, PLEI filed a motion for summary judgment.
4
On August 17 and 18, 1982, a hearing was held in San Diego in the criminal case United States v. Sasway, Crim. No. 82-0504 (S.D.Cal.1982). See PLEI, supra, 556 F.Supp. at 447. In that hearing, DOJ, in order to refute a defense claim of selective prosecution, publicly disclosed its guidelines for prosecuting Selective Service non-registrants. Id. Those guidelines and the cover letter transmitting the guidelines to United States Attorneys were two of the four documents sought by PLEI. On or about September 3, 1982, after the guidelines became public in Sasway, they and the cover letter were released to PLEI. Id.
5
DOJ continued to defend its position with regard to the withholding of the two remaining documents. On September 21, 1982, the District Court issued an order refusing leave to PLEI to amend its complaint and granting summary judgment for DOJ with regard to the two undisclosed documents, sustaining the claim of exemption under 5 U.S.C. Sec. 552(b)(5). App. at 59-60.
6
Subsequently, PLEI moved for an award of attorney's fees and litigation expenses, pursuant to 5 U.S.C. Sec. 552(a)(4)(E). The District Court denied PLEI's motion, holding that PLEI had not substantially prevailed in the FOIA action, as required under section 552(a)(4)(E), because no causal nexus had been shown between PLEI's action and the release of the two documents PLEI received. Alternatively, the District Court held that even if PLEI had substantially prevailed and was eligible for attorney's fees, an analysis of the factors enumerated in Cox v. United States Department of Justice, 601 F.2d 1, 7 (D.C.Cir.1979), for entitlement to such fees, showed that PLEI was not so entitled.
II
7
An award of attorney's fees and litigation costs incurred in pressing an FOIA claim may be made only if the complainant has substantially prevailed. 5 U.S.C. Sec. 552(a)(4)(E). While it is clear that a court order compelling disclosure is not a prerequisite for an award,1 it is also clear that more than post hoc, ergo propter hoc must be shown.2 An FOIA litigant seeking attorney's fees must show that "prosecution of the action could reasonably be regarded as necessary to obtain the information ... and that a causal nexus exists between that action and the agency's surrender of the information ...." Cox v. United States Department of Justice, supra, 601 F.2d at 6 (citations omitted); see also Sweatt v. United States Navy, supra, 683 F.2d at 423-24; Church of Scientology v. Harris, supra, 653 F.2d at 588.
8
To be sure, the Justice Department's release of the two documents at issue in the attorney's fees motion did occur after the filing of an FOIA complaint. However, the initial release of the documents occurred in an unrelated criminal case. Only then did DOJ release the documents to PLEI, specifically representing to the District Court that "[i]n view of the public disclosure of the guidelines, [DOJ] will discontinue its efforts to withhold these materials." Filing of September 3, 1982, App. at 44. The Justice Department released only those documents which had already been publicly disclosed; it did not release the other documents that were the subject of PLEI's FOIA action. The District Court thus concluded that PLEI failed to show a causal nexus between its FOIA action and DOJ's release of the documents.
9
Our review of the District Court's conclusion that PLEI did not substantially prevail in the litigation, so as to be eligible for attorney's fees, is narrow in scope. The findings of fact underlying a conclusion as to whether an FOIA litigant has substantially prevailed are reviewed under a clearly-erroneous standard. See Sweatt v. United States Navy, supra, 683 F.2d at 425; Crooker v. United States Department of the Treasury, supra, 663 F.2d at 142. In this case, there is no dispute as to the findings of fact. Thus, the District Court's findings of fact are manifestly not clearly erroneous.
10
Nor is there any indication that in reaching its conclusion the District Court applied an improper legal standard to those findings of fact.3 PLEI would have us find legal error by interpreting the causal nexus requirement in significantly weakened form. PLEI argues that an FOIA plaintiff need not show that its suit was a direct cause of the release of the documents sought. Appellant's Brief at 28. However, the cases cited for this proposition fail to support it. In each case, the release of the documents was directly attributable to the plaintiff's FOIA action.4 Alternatively, PLEI invites us to infer causality from the timing of the release of the documents. Appellant's Brief at 32-33. Such an inference, however, would be contrary to the law of this Circuit.5
11
There is no indication in the record or in the District Court's findings of fact that would indicate that the PLEI action influenced the DOJ decision to release the documents in Sasway. Nor is there any indication that DOJ simply abandoned its defenses to PLEI's claim. The District Court appears to have understood, and to have correctly applied, the causal nexus requirement. Accordingly, we must accept the District Court's finding that PLEI was not eligible for an award of attorney's fees.
12
Only movants who have prevailed substantially, and are therefore eligible, may be found entitled to an award of attorney's fees and litigation expenses under section 552(a)(4)(E). See Fund for Constitutional Government v. National Archives & Records Service, supra, 656 F.2d at 870; Church of Scientology v. Harris, supra, 653 F.2d at 587; Nationwide Building Maintenance, Inc. v. Sampson, supra, 559 F.2d at 709. Since PLEI is not eligible for an award of attorney's fees and litigation expenses, we have no occasion to comment on the factors that would bear on PLEI's entitlement.6
13
For the foregoing reasons, the judgment of the District Court is
14
Affirmed.
*
Sitting by designation pursuant to 28 U.S.C. Sec. 294(d)
1
Sweatt v. United States Navy, 683 F.2d 420, 423 (D.C.Cir.1982); Fund for Constitutional Government v. National Archives & Records Service, 656 F.2d 856, 871 (D.C.Cir.1981); Church of Scientology v. Harris, 653 F.2d 584, 587 (D.C.Cir.1981); Crooker v. United States Department of the Treasury, 663 F.2d 140, 141 (D.C.Cir.1980); Cox v. United States Department of Justice, 601 F.2d 1, 6 (D.C.Cir.1979); Nationwide Building Maintenance, Inc. v. Sampson, 559 F.2d 704, 708 (D.C.Cir.1977); Cuneo v. Rumsfeld, 553 F.2d 1360, 1364 (D.C.Cir.1977)
2
Sweatt v. United States Navy, supra, 683 F.2d at 423; Church of Scientology v. Harris, supra, 653 F.2d at 587-88; Cox v. United States Department of Justice, supra, 601 F.2d at 6
3
See generally United States v. Singer Manufacturing Co., 374 U.S. 174, 194 n. 9, 83 S.Ct. 1773, 1784 n. 9, 10 L.Ed.2d 823 (1963); Federal Trade Commission v. Texaco, Inc., 555 F.2d 862, 876 n. 29 (D.C.Cir.), cert. denied sub nom. Standard Oil Co. v. Federal Trade Commission, 431 U.S. 974, 97 S.Ct. 2939, |
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187,
187
] | below the armpit. Spread or overlap the line evenly to achieve the correct back length.
3. Redraw lines if needed by blending the pattern lines at the overlap or spread. For preliminary front adjustments, you need to lengthen or shorten the front bodice the same amount as you did the back bodice.
## BUST ADJUSTMENTS
All standard bodice patterns are made for a B-cup bra size. If you are smaller or larger than a B cup, and/or your bust sits higher or lower than average, then you'll want to adjust your pattern before you start to get a better fit.
1. With the elastic still around your waist, look in a mirror and measure vertically from your shoulder, over the fullest part of your bust, and down to your waist. The bodice front needs to be this long to fit properly. Also note the measurement along that line, where the apex of your bust (or bust point, basically your nipple) sits. You'll need this to mark an accurate bust point on your pattern.
2. Measure from side seam to side seam, across the fullest part of your bust. Add 1" (2.5cm) for wearing ease. Divide in half (because the pattern is half of the front). Also note the distance from the side seam to the bust point.
3. On the front bodice pattern, locate the pattern's bust point by drawing straight lines through the center of each dart. Where they intersect is the pattern's bust point. Mark the bust point on the pattern and mark the dotted lines as pictured. Cut along each of these lines, leaving only a small hinge at the armhole and, for the large bust adjustment, also at the bust point to pivot the pieces. For a small bust adjustment cut through the bust point.
4. Working on a flat surface, spread or overlap the pattern pieces as shown until the length and width measurements you took earlier are achieved. Keep the waistline of the bodice even and the center-front line even. A general rule will be to increase/decrease length and width about ½" (13mm) per change in cup size. For instance, a D cup will add about 1" (2.5cm) in length and width. Tape the altered pattern in place.
5. Mark the correct bust point on the pattern as you measured on yourself earlier, both the height (as measured from your shoulder) and the width (as measured from the side seam). Mark new waist and bust dart points as follows: The point of the waist dart will be 1" (2.5cm) directly below your new bust point. The side dart point will be 1" (2.5cm) away from your bust point, in the direction of the dart (to the side and slightly down). Connect these new points to the end of the legs of the original darts, which have now spread (for larger cups) or overlapped (for smaller cups). Redraw pattern lines smoothing out any bumps or jags caused by the alteration.
6. If the bust point is higher than its original position, redraw the darts to point toward the higher point.
In cases where the corrected bust point is lower than the side dart end points, the side dart end points will also have to be lowered. Measure the distance that the bust point was lowered. Lower the end points of the dart legs the same distance, taking care to lower them vertically. In other words, move the entire side dart downward, not just the tip, on the spread-out or overlapped pattern. This keeps the width of the front bodice consistent. Draw in the new dart legs, lowering the tip of the waist dart the same amount the bust dart was lowered on the spread or overlapped pattern.
7. To complete the pattern, redraw the side seam by connecting the new dart legs with the armhole and the waistline for the spread or overlapped pattern.
## NECK ADJUSTMENTS
If the neckline is too tight or too loose, adjust the pattern accordingly.
1. Measure around your neck where you'd like the finished neckline to sit. Divide the measurement in half as you are working with half the pattern.
2. Mark the stitching lines for the neck and shoulder on both the front and back bodice, ⅝" (1.5cm) in from the cutting edge. Line up the shoulder stitching lines and tape in place. Don't worry about the shoulder dart. Measure the stitching line for the neck by holding a soft, flexible tape measure on its side (that is, standing up on its thin edge), not flat, around the neck stitching line. Hold it so the increments are against the pattern for the most accurate measure.
3. For every 1" (2.5cm) difference between the stitching line and the target measure, move the pattern's neckline ¼" (6mm) at the center front and at the shoulder line, either in, toward the neck to make it smaller, or out, away from the neck to make it bigger. For example, if you want to increase the neck 1" (2.5cm), you'll move the center-front point down ¼" (6mm) and the shoulder line out ¼" (6mm). Keep the center back the same. Redraw the neck stitching line, and double-check the pattern measure. Add the ⅝" (1.5cm) seam allowance to the stitching line. Adjust again if needed.
## SHOULDER ADJUSTMENTS
### SHOULDER SLOPE CORRECTION
This method will correct for wide or narrow shoulders, as well as square or sloping shoulders.
1. Have a friend measure across your back, from shoulder point to shoulder point, where sleeve seams would sit. This is your shoulder width. Divide this by 2, since the pattern is for half of the back. Then, with the elastic around your waist, have a friend measure from your waist at center back, to your shoulder point, where a sleeve seam would sit. This is the shoulder slope.
2. Compare your shoulder width (that you've divided by 2) to the bodice back, omitting the seam allowances. If you're within ¼" (6mm), you'll be fine. If not, you'll want to correct for shoulder width. Do this before correcting for shoulder slope. Draw a horizontal guideline, parallel to the waist, through the shoulder point. Starting at center back, measure along this line to your target shoulder width. Make a mark on the line. Next, draw a vertical line through your mark, keeping it perpendicular to the waistline to mark the wider or narrower shoulder.
3. Starting at the waist at center back, mark where your shoulder-slope measure crosses the vertical line. This is your new shoulder point. Note how far above or below the original shoulder point this is, as you will need to adjust the armhole this same amount. Draw your new shoulder line from this point to the neck.
4. Find the midpoint of your new shoulder line. This will be the center of your shoulder dart. At the midpoint, draw a line perpendicular to your shoulder line that is the same length as the original dart. This is your dart center, and the end is your dart point. Measure the width of the original dart. Mark the dart width on the shoulder line with the perpendicular line in the center. Draw in your dart legs, connecting these marks to the end of the perpendicular line.
5. Correct the armhole as needed:
If your shoulder width was adjusted, but not the shoulder slope, redraw your armhole, starting at the shoulder, and blend back into the existing armhole about midway down the curve for the wider or narrower shoulder.
If your shoulder slope was also changed, draw a vertical guideline at the outer point of the armhole/side seam, perpendicular to the waist. Mark a new point along this guideline up or down—the same amount that you raised or lowered the shoulder point. This keeps the armhole the same size. To redraw this line, try to mimic the bottom of the curve through the midpoint of the curve. Then blend to your new shoulder point for a wider or narrower shoulder.
6. Apply the same changes to the front bodice: Draw a horizontal guideline through the front bodice shoulder point. Move the shoulder point in or out the same amount that you moved the back shoulder. Draw a vertical line through this new point. Now raise or lower the shoulder point the same amount that you raised or lowered it in the back, to correct for shoulder slope. Connect this mark to the original neckline. Redraw the armhole as in step 5.
7. When you change the armhole on the bodice, you then must change the armhole on the sleeve so it still fits into the bodice. For shoulder width adjustments, you may or may not need to adjust the armhole, depending on the changes. Measure the original armhole stitching lines on the back bodice. Now measure your new armhole on your back bodice, along the stitching lines. The difference between the two measurements is the amount that you will raise or lower the sleeve cap. If your new armhole is bigger than the original armhole, you will raise the sleeve cap by that same amount. If your new armhole is smaller than the original armhole, you will lower the sleeve cap by that amount.
### ROUNDED SHOULDERS
For figures with rounded shoulders, there are often gaping armholes in the back, and when viewed from the side, the shoulders are forward from the neck and the back is more prominent than the front.
|
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] | ndigung: Ein Geistergespräch zwischen Lyotard und Habermas_ (Frankfurt: Suhrkamp, 1988). 11 Albrecht Wellmer, "On the Dialectic of Modernism and Postmodernism," trans. D. Roberts, _Praxis International_ , 5.5 (1985): 337–62. 12 Axel Honneth, _Critique of Power: Reflective Stages in a Critical Social Theory_ , trans. K. Baynes (Cambridge, MA: MIT Press), 1993. 13 See J. Habermas, _The Philosophical Discourse of Modernity: Twelve Lectures_ , trans. F. G. Lawrence (Cambridge, MA: MIT Press, 1998), here pp. 83–105. 14 See J.-F. Lyotard, _Des dispositifs pulsionnels_ (Paris: Bourgois, 1973), p. 118. [Translator's note: The chapter on "Adorno as the Devil" is available in English in Robert Hurley's translation in _Telos_ , 19 (1974): 128–37.] 15 Lyotard, _The Postmodern Explained to Children_ , p. 78. 16 The relationship between Adorno and Lyotard is analyzed in all its twists and turns by M. Cohen-Halimi, _Stridence spéculative: Adorno, Lyotard, Derrida_ (Paris: Payot, 2014), through oblique reference to Derrida. At the Cerisy-La-Salle conference – whose proceedings were later collected in the volume _Les Fins de l'homme: À partir du travail de Jacques Derrida_ (Paris: Galilée, 1981) – Lyotard asked Derrida to speak about his relationship with Adorno. The answer came only several years later, in 2001, when Derrida received the Adorno prize and gave a speech later published in _Fichus_ (Paris: Galilée, 2002) in which he accorded Adorno _le mérite indéniable_ of having reopened the question on the meaning of the phrase "after Auschwitz." 17 J.-F. Lyotard, _Discours, Figures_ , trans. A. Hudek and M. Lydon (with introduction by J. Mowitt; (Minneapolis: University of Minnesota Press, 2011 [1971]). 18 As Alain Badiou expresses it in "Custos, quid noctis?" [1983], in idem, _The Adventure of French Philosophy_ , 223–39, here p. 231. 19 See especially J.-F. Lyotard, _The Differend: Phrases in Dispute_ , trans. G. van den Abbeele (Minneapolis: University of Minnesota Press, 1988). 20 Lyotard, _The Postmodern Explained to Children_ , pp. 15–16. 21 Ibid., p. 16. 22 J.-F. Lyotard, _Heidegger and "the Jews,"_ trans. A. Michel and M. Roberts (with foreword by D. Carroll; Minneapolis: University of Minnesota Press, 1990), p. 84. 23 J.-F. Lyotard, _Enthusiasm_ , trans. G. van den Abbeele (Stanford, CA: Stanford University Press, 2009 [1986]), p. 58.
# Part III
French Theory
# 7
Difference and History
Perhaps no definition of French theory hits the mark better than Baudrillard's, according to which "it exists only when our eyes are closed."1 Like a fantasy imprinted in the mind but lacking any correspondence in reality, it is only recognizable by its effects – which radiated out from American campuses onto the global cultural stage over the span of a few years. As François Cusset observes in the most convincing reconstruction of the affair, it involved something different from and bigger than what other waves of cultural importation had brought from France to America. While surrealism, existentialism, and "Annales" historiography were transplanted in their native form before being Americanized, French theory was a product created from scratch by American intellectuals after a small squad of French philosophers arrived in the United States. Cogently defined as "an American interpretation of French readings of German philosophers,"2 it appears to be the result of a dual decontextualization – of German philosophical culture, as operated by the French, and of French philosophical culture, as operated by the Americans. The same liberty that Derrida, Deleuze, and Foucault took in reworking texts by Hegel, Nietzsche, and Heidegger was practiced by American interpreters on French authors. As had already happened the first time round, the effect of this second contamination was twofold. Although it is true that the French texts lost something of their original character by being first denationalized and then reterritorialized, once they came into contact with the new context they acquired a new-found energy, which projected them into the international circuit, in English translation. Certainly a French book arriving in Tokyo or Sydney through American mediation is no longer the same as it was. But, instead of diminishing its impact, this ended up boosting its force, as more meanings came to be layered on top of the original ones.
Without retracing the ambivalent effects of French theory on American culture, which have been thoroughly examined by Cusset, I will stick to the relationship with German philosophy, transplanted in America by intellectuals who fled Nazi Germany. The general turnover in hegemony witnessed by the marginalization of Marcuse's thought was followed by a hybridization that blurred the European contrasts. What in Europe had taken on the features of a genuine _Kulturkampf_ in America became a composite of heterogeneous elements. American authors such as Nancy Fraser, Seyla Benhabib, and Martin Jay introduced Frankfurt School theories into the American context, while others, such as Silvère Lotringer, Judith Butler, and Gayatri Spivak circulated theories from France in a horizon marked by the interweaving of different lexicons. These grafts between French thinkers and German philosophy, already attempted in Europe by Wellmer and Honneth, intensified until among them they fused forms of thought of different origins, in a typically American, transnational model.
Nevertheless, some differences did remain, associated with the different meanings that the term "theory" acquired in the two contexts. With the Frankfurt thinkers it retained a clear philosophical inflection, but in France "theory" tended to express a potential of meaning that, if not contrary to philosophy, was certainly not entirely coincident with it. Incongruent with the traditional meaning of "doctrine" (according to the use deriving from the German term _Lehre_ ), the French version of _théorie_ stemmed partly from the development of the human sciences and partly from the Marxist critique of ideology, as developed chiefly by Althusser, through the notion of "theoretical practice." This meaning, inspired by an ideal of scientificity that is not specifically theoretical in tone, gained currency in the disciplines of linguistics (Saussure), anthropology (Lévi-Strauss), psychoanalysis (Lacan), and literary studies (Barthes), in line with the rationalist cast of history of science (Lecourt).3 Thus, while critical theory in Frankfurt focused on the "criticality" pole from a philosophical angle, in Paris the stress was placed on a notion of "theory" with an antitheoretical leaning.
In an article entitled "Doing Theory," Silvère Lotringer, perhaps the most important mediator of French theory in America, argues that its peculiar trait lies precisely in its lack of theoretical assumptions in favor of a practice of writing that prefers to dictate its own rules. Unlike _Kritische Theorie_ , which was guided by precise doctrinal premises, French theory had as an essential characteristic that it was not "to be something" but "to become everything it is capable of."4 From this point of view, in principle, it eludes any stable definition, taking on the meaning given to it from one time to the next. This explains its attitude of embracing even markedly heterogeneous theoretical presuppositions and semantic vectors, such as those adopted by Derrida, Foucault, Deleuze, Baudrillard, and Lyotard, to name only the major players. For this reason, in an interview "On Theory" – as well as in the talk he gave at the 1966 conference at Johns Hopkins University that effectively inaugurated the American period of French theory – Roland Barthes asserted the structurally "intransitive" pursuit of theory. It has no other object than itself, in all possible versions, including that of its own negation, to the point that even the antitheoretical polemic tends to become a genre within the very theory it aims to refute.5
If the protocols of French theory have been held responsible for both identity and difference politics in American public discourse, inferring a particular political goal from the various deconstructive practices is difficult and somewhat arbitrary. What they aim to challenge on a metapolitical plane is the form of representation – understood as the subject's apparatus for controlling reality. The reason why the structure of signification comes under attack, in all its possible modes, is that it is inevitably partial, and therefore excludes all other possible meanings. Opposed to it is the complete commutability of utterances, which are conveyed in such a way as to neutralize each other. Thus, for example, Baudrillard's argument on the equivalence between use value and exchange value serves to criticize capitalism as well as to overcome Marxism – but also, at the same time, to affirm one and the other |
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---
abstract: 'Quantum algorithms are usually described as monolithic circuits, becoming large at modest input size. Near-term quantum architectures can only manage a small number of qubits. We develop an automated method to distribute quantum circuits over multiple agents, minimising quantum communication between them. We reduce the problem to hypergraph partitioning and then solve it with state-of-the-art optimisers. This makes our approach useful in practice, unlike previous methods. Our implementation is evaluated on five quantum circuits of practical relevance.'
author:
- 'Pablo Andr[é]{}s-Mart[í]{}nez'
- Chris Heunen
bibliography:
- 'Bibliography.bib'
title: Automated distribution of quantum circuits via hypergraph partitioning
---
[^1]
[^2]
Introduction
============
Quantum computation [@feynman; @nielsenchuang; @lloyd:simulators] employs the laws of quantum mechanics to design systems capable of outperforming classical computers in certain problems [@Shor; @Grover; @harrowhassadimlloyd:linear]. Over the past couple of decades, this idea has rapidly developed from theoretical results into actual quantum technology [@obrienfurusawavuckovic:photonic; @devoretschoelkopf:superconducting; @horodecki:entanglement].
Although there are other approaches [@raussendorfbriegel:mbqc], the dominant way to present a quantum algorithm is as a quantum circuit [@deutsch:networks]: a description of how quantum devices, chosen from a fixed finite set, are applied to different parts of the input system; see Figure \[fig:circuit\] for an example. Each of the ‘wires’ that quantum devices act upon typically consist of a two level quantum system called a quantum bit or qubit. The qubit count grows with the input size, and for relevant problems such as the *unique shortest vector* problem (with applications in cryptography [@USV]) the circuit grows large: lattice dimension 3 already requires 842 qubits and 95,624 gates [^3].
Near-term quantum computing architectures are not capable of executing such large circuits. We are currently entering the era of Noisy Intermediate-Scale Quantum (NISQ) technology [@NISQ], being able to fabricate small quantum computing units (QPU for short) ranging from $10$ to almost $100$ qubits. Much effort is being dedicated to further increase the number of qubits that QPUs can manage, but as the number of qubits grows, the challenge of addressing each qubit individually and shielding them from unwanted interactions and decoherence rapidly becomes unmanageable [@vanmeterdevitt:survey]. To scale up beyond this point, researchers are proposing distributed quantum architectures |
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