diff --git a/AUTHORS.rst b/AUTHORS.rst
index f067a45..8f9d29a 100644
--- a/AUTHORS.rst
+++ b/AUTHORS.rst
@@ -24,6 +24,7 @@ Alphabetical list of contributors
 * Mihai Cara (@mcara)
 * James Davenport (@jradavenport)
 * Christoph Deil (@cdeil)
+* Timothy P. Ellsworth-Bowers (@tbowers7)
 * Carlos Gomez (@carlgogo)
 * Hans Moritz Günther (@hamogu)
 * Forrest Gasdia (@EP-Guy)
diff --git a/CHANGES.rst b/CHANGES.rst
index d21f3a1..4205d74 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -4,6 +4,9 @@
 New Features
 ^^^^^^^^^^^^
 
+- Improve integration of ``ImageFileCollection`` with image combination
+  and document that integration [#762]
+
 Other Changes and Additions
 ^^^^^^^^^^^^^^^^^^^^^^^^^^^
 - Add memory_profiler as a test requirement [#739]
@@ -14,10 +17,14 @@ Bug Fixes
 ^^^^^^^^^
 
 - ``test_image_collection.py`` in the test suite no longer produces
- permanent files on disk and cleans up after itself. [#738]
+  permanent files on disk and cleans up after itself. [#738]
 
 - Change ``Combiner`` to allow accepting either a list or a generator [#757]
 
+- ``ImageFileCollection`` now correctly returns an empty collection when
+  an existing collection is filtered restrictively enough to remove all
+  files.  [#750]
+
 2.1.0 (2019-12-24)
 ------------------
 
diff --git a/ccdproc/combiner.py b/ccdproc/combiner.py
index 39f3e28..d85c55e 100644
--- a/ccdproc/combiner.py
+++ b/ccdproc/combiner.py
@@ -676,8 +676,12 @@ def combine(img_list, output_file=None,
         elif isinstance(img_list, str) and (',' in img_list):
             img_list = img_list.split(',')
         else:
-            raise ValueError(
-                "unrecognised input for list of images to combine.")
+            try:
+                # Maybe the input can be made into a list, so try that
+                img_list = list(img_list)
+            except TypeError:
+                raise ValueError(
+                    "unrecognised input for list of images to combine.")
 
     # Select Combine function to call in Combiner
     if method == 'average':
diff --git a/ccdproc/image_collection.py b/ccdproc/image_collection.py
index 6fd9f6b..ff58c46 100644
--- a/ccdproc/image_collection.py
+++ b/ccdproc/image_collection.py
@@ -448,7 +448,9 @@ class ImageFileCollection:
             else:
                 files = self._filenames
         else:
-            files = self._fits_files_in_directory()
+            # Check if self.location is set, otherwise proceed with empty list
+            if self.location != '':
+                files = self._fits_files_in_directory()
 
             if self.glob_include is not None:
                 files = fnmatch.filter(files, self.glob_include)
diff --git a/docs/image_combination.rst b/docs/image_combination.rst
index 0922d21..012fa5b 100644
--- a/docs/image_combination.rst
+++ b/docs/image_combination.rst
@@ -4,9 +4,13 @@ Combining images and generating masks from clipping
 ===================================================
 
 .. note::
-    No attempt has been made yet to optimize memory usage in
-    `~ccdproc.Combiner`. A copy is made, and a mask array
-    constructed, for each input image.
+    There are currently two interfaces to image combination. One is through
+    the `~ccdproc.Combiner` class, the other through the `~ccdproc.combine`
+    function. They offer *almost* identical capabilities. The primary
+    difference is that `~ccdproc.combine` allows you to place an upper
+    limit on the amount of memory used.
+
+    Work to improve the performance of image combination is ongoing.
 
 
 The first step in combining a set of images is creating a
@@ -133,6 +137,48 @@ using `~ccdproc.Combiner.average_combine` or
 `~ccdproc.Combiner.median_combine`).
 
 
+.. _combination_with_IFC
+Image combination using `~ccdproc.ImageFileCollection`
+------------------------------------------------------
+
+There are a couple of ways that image combination can be done if you are using
+`~ccdproc.ImageFileCollection` to
+:ref:`manage a folder of images <image_management>`.
+
+For this example, a temporary folder with images in it is created:
+
+    >>> from tempfile import mkdtemp
+    >>> from pathlib import Path
+    >>> import numpy as np
+    >>> from astropy.nddata import CCDData
+    >>> from ccdproc import ImageFileCollection, Combiner, combine
+    >>>
+    >>> ccd = CCDData(np.ones([5, 5]), unit='adu')
+    >>>
+    >>> # Make a temporary folder as a path object
+    >>> image_folder = Path(mkdtemp())
+    >>> # Put several copies ccd in the temporary folder
+    >>> _ = [ccd.write(image_folder / f"ccd-{i}.fits") for i in range(3)]
+    >>> ifc = ImageFileCollection(image_folder)
+
+To combine images using the `~ccdproc.Combiner` class you can use the ``ccds``
+method of the `~ccdproc.ImageFileCollection`:
+
+    >>> c = Combiner(ifc.ccds())
+    >>> avg_combined = c.average_combine()
+
+There two ways combine images using the `~ccdproc.combine` function. If the
+images are large enough to combine in memory, then use the file names as the argument to `~ccdproc.combine`, like this:
+
+    >>> avg_combo_mem_lim = combine(ifc.files_filtered(include_path=True),
+    ...                             mem_limit=1e9)
+
+If memory use is not an issue, then the ``ccds`` method can be used here too:
+
+    >>> avg_combo = combine(ifc.ccds())
+
+
+
 .. _reprojection:
 
 Combination with image transformation and alignment
diff --git a/setup.cfg b/setup.cfg
index fac559b..827bd83 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -4,6 +4,7 @@ minversion = 2.2
 testpaths = "ccdproc" "docs"
 norecursedirs = build docs/_build
 doctest_plus = enabled
+addopts = --doctest-rst
 markers =
     data_size(N): set dimension of square data array for ccd_data fixture
     data_scale(s): set the scale of the normal distribution used to generate data

diff --git a/ccdproc/tests/test_combiner.py b/ccdproc/tests/test_combiner.py
index b758c66..1c158a0 100644
--- a/ccdproc/tests/test_combiner.py
+++ b/ccdproc/tests/test_combiner.py
@@ -10,6 +10,7 @@ from astropy.utils.data import get_pkg_data_filename
 from astropy.nddata import CCDData
 
 from ccdproc.combiner import Combiner, combine, _calculate_step_sizes
+from ccdproc.image_collection import ImageFileCollection
 from ccdproc.tests.pytest_fixtures import ccd_data as ccd_data_func
 
 
@@ -373,6 +374,43 @@ def test_combiner_result_dtype():
     np.testing.assert_array_almost_equal(res.data, ref)
 
 
+def test_combiner_image_file_collection_input(tmp_path):
+    # Regression check for #754
+    ccd = ccd_data_func()
+    for i in range(3):
+        ccd.write(tmp_path / f'ccd-{i}.fits')
+
+    ifc = ImageFileCollection(tmp_path)
+    comb = Combiner(ifc.ccds())
+    np.testing.assert_array_almost_equal(ccd.data,
+                                         comb.average_combine().data)
+
+
+def test_combine_image_file_collection_input(tmp_path):
+    # Another regression check for #754 but this time with the
+    # combine function instead of Combiner
+    ccd = ccd_data_func()
+    for i in range(3):
+        ccd.write(tmp_path / f'ccd-{i}.fits')
+
+    ifc = ImageFileCollection(tmp_path)
+
+    comb_files = combine(ifc.files_filtered(include_path=True),
+                         method='average')
+
+    comb_ccds = combine(ifc.ccds(), method='average')
+
+    np.testing.assert_array_almost_equal(ccd.data,
+                                         comb_files.data)
+    np.testing.assert_array_almost_equal(ccd.data,
+                                         comb_ccds.data)
+
+    with pytest.raises(FileNotFoundError):
+        # This should fail because the test is not running in the
+        # folder where the images are.
+        _ = combine(ifc.files_filtered())
+
+
 # test combiner convenience function works with list of ccddata objects
 def test_combine_average_ccddata():
     fitsfile = get_pkg_data_filename('data/a8280271.fits')

ImageFileCollection not integrated into combine and Combiner
The documentation for ccdproc's ImageFileCollection does not explain how to use ImageFileCollections to combine files. In addition, since ImageFileCollection works on a directory, the results of the method ImageFileCollection.files doesn't have the needed path.  As a result:
- `combine(image_collection.files)` fails with a `FileNotFoundError`.   
- `combine(image_collection.ccds` fails with `ValueError: unrecognised input for list of images to combine.`
- `Combiner(image_collection.ccds())` fails with `TypeError: object of type 'generator' has no len()`

How can one gather a bunch of fits files in ImageFileCollection, and then combine them with ccdproc.combine?  It almost seems like ImageFileCollection and combine/Combiner are two different packages that don't talk to each other. 
ccdproc/tests/test_combiner.py::test_combine_image_file_collection_input
ccdproc/tests/test_combiner.py::test_weights ccdproc/tests/test_combiner.py::test_average_combine_uncertainty ccdproc/tests/test_combiner.py::test_combine_numpyndarray ccdproc/tests/test_combiner.py::test_3d_combiner_with_scaling ccdproc/tests/test_combiner.py::test_ccddata_combiner_objects ccdproc/tests/test_combiner.py::test_combiner_sum ccdproc/tests/test_combiner.py::test_combiner_init_with_none ccdproc/tests/test_combiner.py::test_clip_extrema_via_combine ccdproc/tests/test_combiner.py::test_combiner_scaling_fails ccdproc/tests/test_combiner.py::test_ccddata_combiner_size ccdproc/tests/test_combiner.py::test_writeable_after_combine[average_combine] ccdproc/tests/test_combiner.py::test_combiner_sigmaclip_single_pix ccdproc/tests/test_combiner.py::test_combiner_minmax_min ccdproc/tests/test_combiner.py::test_combine_limitedmem_scale_fitsimages ccdproc/tests/test_combiner.py::test_1Dweights ccdproc/tests/test_combiner.py::test_combiner_empty ccdproc/tests/test_combiner.py::test_combiner_mask_sum ccdproc/tests/test_combiner.py::test_combiner_minmax_max ccdproc/tests/test_combiner.py::test_ystep_calculation[10000-expected4] ccdproc/tests/test_combiner.py::test_combiner_sigmaclip_high ccdproc/tests/test_combiner.py::test_ystep_calculation[2999-expected3] ccdproc/tests/test_combiner.py::test_writeable_after_combine[median_combine] ccdproc/tests/test_combiner.py::test_combiner_gen ccdproc/tests/test_combiner.py::test_combiner_minmax ccdproc/tests/test_combiner.py::test_combiner_mask_average ccdproc/tests/test_combiner.py::test_writeable_after_combine[sum_combine] ccdproc/tests/test_combiner.py::test_combiner_result_dtype ccdproc/tests/test_combiner.py::test_combiner_uncertainty_average_mask ccdproc/tests/test_combiner.py::test_combiner_with_scaling ccdproc/tests/test_combiner.py::test_ccddata_combiner_units ccdproc/tests/test_combiner.py::test_weights_shape ccdproc/tests/test_combiner.py::test_median_combine_uncertainty ccdproc/tests/test_combiner.py::test_combiner_sigmaclip_low ccdproc/tests/test_combiner.py::test_combiner_dtype ccdproc/tests/test_combiner.py::test_combiner_create ccdproc/tests/test_combiner.py::test_clip_extrema_with_other_rejection ccdproc/tests/test_combiner.py::test_combiner_average ccdproc/tests/test_combiner.py::test_combine_average_fitsimages ccdproc/tests/test_combiner.py::test_ystep_calculation[2001-expected2] ccdproc/tests/test_combiner.py::test_combiner_mask_median ccdproc/tests/test_combiner.py::test_combiner_uncertainty_sum_mask ccdproc/tests/test_combiner.py::test_combiner_mask ccdproc/tests/test_combiner.py::test_combiner_uncertainty_average ccdproc/tests/test_combiner.py::test_combiner_uncertainty_median_mask ccdproc/tests/test_combiner.py::test_clip_extrema_3d ccdproc/tests/test_combiner.py::test_ystep_calculation[1500-expected1] ccdproc/tests/test_combiner.py::test_combine_limitedmem_fitsimages ccdproc/tests/test_combiner.py::test_ystep_calculation[53-expected0] ccdproc/tests/test_combiner.py::test_sum_combine_uncertainty ccdproc/tests/test_combiner.py::test_combiner_image_file_collection_input ccdproc/tests/test_combiner.py::test_combine_average_ccddata ccdproc/tests/test_combiner.py::test_combiner_median ccdproc/tests/test_combiner.py::test_combiner_3d ccdproc/tests/test_combiner.py::test_clip_extrema