diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index ceb534d..71e4ce4 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -1,6 +1,14 @@
 Changelog
 ---------
 
+6.0.0b6 (Unreleased)
+********************
+
+Refactoring:
+
+* Remove the cache attached to webargs parsers. Due to changes between webargs
+  v5 and v6, the cache is no longer considered useful.
+
 6.0.0b5 (2020-01-30)
 ********************
 
diff --git a/src/webargs/aiohttpparser.py b/src/webargs/aiohttpparser.py
index 47ac1bc..c41cbe4 100644
--- a/src/webargs/aiohttpparser.py
+++ b/src/webargs/aiohttpparser.py
@@ -84,10 +84,8 @@ class AIOHTTPParser(AsyncParser):
 
     async def load_form(self, req: Request, schema: Schema) -> MultiDictProxy:
         """Return form values from the request as a MultiDictProxy."""
-        post_data = self._cache.get("post")
-        if post_data is None:
-            self._cache["post"] = await req.post()
-        return MultiDictProxy(self._cache["post"], schema)
+        post_data = await req.post()
+        return MultiDictProxy(post_data, schema)
 
     async def load_json_or_form(
         self, req: Request, schema: Schema
@@ -99,22 +97,17 @@ class AIOHTTPParser(AsyncParser):
 
     async def load_json(self, req: Request, schema: Schema) -> typing.Dict:
         """Return a parsed json payload from the request."""
-        json_data = self._cache.get("json")
-        if json_data is None:
-            if not (req.body_exists and is_json_request(req)):
+        if not (req.body_exists and is_json_request(req)):
+            return core.missing
+        try:
+            return await req.json(loads=json.loads)
+        except json.JSONDecodeError as e:
+            if e.doc == "":
                 return core.missing
-            try:
-                json_data = await req.json(loads=json.loads)
-            except json.JSONDecodeError as e:
-                if e.doc == "":
-                    return core.missing
-                else:
-                    return self._handle_invalid_json_error(e, req)
-            except UnicodeDecodeError as e:
+            else:
                 return self._handle_invalid_json_error(e, req)
-
-            self._cache["json"] = json_data
-        return json_data
+        except UnicodeDecodeError as e:
+            return self._handle_invalid_json_error(e, req)
 
     def load_headers(self, req: Request, schema: Schema) -> MultiDictProxy:
         """Return headers from the request as a MultiDictProxy."""
diff --git a/src/webargs/asyncparser.py b/src/webargs/asyncparser.py
index f67dc57..0eb6037 100644
--- a/src/webargs/asyncparser.py
+++ b/src/webargs/asyncparser.py
@@ -35,7 +35,6 @@ class AsyncParser(core.Parser):
 
         Receives the same arguments as `webargs.core.Parser.parse`.
         """
-        self.clear_cache()  # in case someone used `location_load_*()`
         req = req if req is not None else self.get_default_request()
         if req is None:
             raise ValueError("Must pass req object")
diff --git a/src/webargs/core.py b/src/webargs/core.py
index fbe1983..b5fe2f9 100644
--- a/src/webargs/core.py
+++ b/src/webargs/core.py
@@ -2,7 +2,6 @@ import functools
 import inspect
 import logging
 import warnings
-from copy import copy
 from collections.abc import Mapping
 import json
 
@@ -130,8 +129,6 @@ class Parser:
         self.location = location or self.DEFAULT_LOCATION
         self.error_callback = _callable_or_raise(error_handler)
         self.schema_class = schema_class or self.DEFAULT_SCHEMA_CLASS
-        #: A short-lived cache to store results from processing request bodies.
-        self._cache = {}
 
     def _get_loader(self, location):
         """Get the loader function for the given location.
@@ -207,15 +204,6 @@ class Parser:
             )
         return schema
 
-    def _clone(self):
-        """Clone the current parser in order to ensure that it has a fresh and
-        independent cache. This is used whenever `Parser.parse` is called, so
-        that these methods always have separate caches.
-        """
-        clone = copy(self)
-        clone.clear_cache()
-        return clone
-
     def parse(
         self,
         argmap,
@@ -250,32 +238,20 @@ class Parser:
             raise ValueError("Must pass req object")
         data = None
         validators = _ensure_list_of_callables(validate)
-        parser = self._clone()
         schema = self._get_schema(argmap, req)
         try:
-            location_data = parser._load_location_data(
+            location_data = self._load_location_data(
                 schema=schema, req=req, location=location or self.location
             )
             result = schema.load(location_data)
             data = result.data if MARSHMALLOW_VERSION_INFO[0] < 3 else result
-            parser._validate_arguments(data, validators)
+            self._validate_arguments(data, validators)
         except ma.exceptions.ValidationError as error:
-            parser._on_validation_error(
+            self._on_validation_error(
                 error, req, schema, error_status_code, error_headers
             )
         return data
 
-    def clear_cache(self):
-        """Invalidate the parser's cache.
-
-        This is usually a no-op now since the Parser clone used for parsing a
-        request is discarded afterwards.  It can still be used when manually
-        calling ``parse_*`` methods which would populate the cache on the main
-        Parser instance.
-        """
-        self._cache = {}
-        return None
-
     def get_default_request(self):
         """Optional override. Provides a hook for frameworks that use thread-local
         request objects.
@@ -458,19 +434,14 @@ class Parser:
         # `_handle_invalid_json_error` and `_raw_load_json`
         # these methods are not part of the public API and are used to simplify
         # code sharing amongst the built-in webargs parsers
-        if "json" not in self._cache:
-            try:
-                json_data = self._raw_load_json(req)
-            except json.JSONDecodeError as e:
-                if e.doc == "":
-                    json_data = missing
-                else:
-                    return self._handle_invalid_json_error(e, req)
-            except UnicodeDecodeError as e:
-                return self._handle_invalid_json_error(e, req)
-            self._cache["json"] = json_data
-
-        return self._cache["json"]
+        try:
+            return self._raw_load_json(req)
+        except json.JSONDecodeError as e:
+            if e.doc == "":
+                return missing
+            return self._handle_invalid_json_error(e, req)
+        except UnicodeDecodeError as e:
+            return self._handle_invalid_json_error(e, req)
 
     def load_json_or_form(self, req, schema):
         """Load data from a request, accepting either JSON or form-encoded
diff --git a/src/webargs/falconparser.py b/src/webargs/falconparser.py
index b64a4a3..6b68afb 100644
--- a/src/webargs/falconparser.py
+++ b/src/webargs/falconparser.py
@@ -91,9 +91,7 @@ class FalconParser(core.Parser):
 
             The request stream will be read and left at EOF.
         """
-        form = self._cache.get("form")
-        if form is None:
-            self._cache["form"] = form = parse_form_body(req)
+        form = parse_form_body(req)
         if form is core.missing:
             return form
         return MultiDictProxy(form, schema)

diff --git a/tests/test_flaskparser.py b/tests/test_flaskparser.py
index c00ae11..f5f70e8 100644
--- a/tests/test_flaskparser.py
+++ b/tests/test_flaskparser.py
@@ -1,5 +1,3 @@
-import threading
-
 from werkzeug.exceptions import HTTPException
 import pytest
 
@@ -126,37 +124,3 @@ def test_abort_has_serializable_data():
     error = json.loads(serialized_error)
     assert isinstance(error, dict)
     assert error["message"] == "custom error message"
-
-
-def test_json_cache_race_condition():
-    app = Flask("testapp")
-    lock = threading.Lock()
-    lock.acquire()
-
-    class MyField(fields.Field):
-        def _deserialize(self, value, attr, data, **kwargs):
-            with lock:
-                return value
-
-    argmap = {"value": MyField()}
-    results = {}
-
-    def thread_fn(value):
-        with app.test_request_context(
-            "/foo",
-            method="post",
-            data=json.dumps({"value": value}),
-            content_type="application/json",
-        ):
-            results[value] = parser.parse(argmap)["value"]
-
-    t1 = threading.Thread(target=thread_fn, args=(42,))
-    t2 = threading.Thread(target=thread_fn, args=(23,))
-    t1.start()
-    t2.start()
-    lock.release()
-    t1.join()
-    t2.join()
-    # ensure we didn't get contaminated by a parallel request
-    assert results[42] == 42
-    assert results[23] == 23
diff --git a/tests/test_tornadoparser.py b/tests/test_tornadoparser.py
index 542365e..50e281b 100644
--- a/tests/test_tornadoparser.py
+++ b/tests/test_tornadoparser.py
@@ -51,9 +51,6 @@ def test_tornado_multidictproxy():
 
 
 class TestQueryArgs:
-    def setup_method(self, method):
-        parser.clear_cache()
-
     def test_it_should_get_single_values(self):
         query = [("name", "Aeschylus")]
         request = make_get_request(query)
@@ -75,9 +72,6 @@ class TestQueryArgs:
 
 
 class TestFormArgs:
-    def setup_method(self, method):
-        parser.clear_cache()
-
     def test_it_should_get_single_values(self):
         query = [("name", "Aristophanes")]
         request = make_form_request(query)
@@ -99,9 +93,6 @@ class TestFormArgs:
 
 
 class TestJSONArgs:
-    def setup_method(self, method):
-        parser.clear_cache()
-
     def test_it_should_get_single_values(self):
         query = {"name": "Euripides"}
         request = make_json_request(query)
@@ -162,14 +153,10 @@ class TestJSONArgs:
     def test_it_should_handle_value_error_on_parse_json(self):
         request = make_request("this is json not")
         result = parser.load_json(request, author_schema)
-        assert parser._cache.get("json") == missing
         assert result is missing
 
 
 class TestHeadersArgs:
-    def setup_method(self, method):
-        parser.clear_cache()
-
     def test_it_should_get_single_values(self):
         query = {"name": "Euphorion"}
         request = make_request(headers=query)
@@ -190,9 +177,6 @@ class TestHeadersArgs:
 
 
 class TestFilesArgs:
-    def setup_method(self, method):
-        parser.clear_cache()
-
     def test_it_should_get_single_values(self):
         query = [("name", "Sappho")]
         request = make_files_request(query)
@@ -221,9 +205,6 @@ class TestErrorHandler:
 
 
 class TestParse:
-    def setup_method(self, method):
-        parser.clear_cache()
-
     def test_it_should_parse_query_arguments(self):
         attrs = {"string": fields.Field(), "integer": fields.List(fields.Int())}
 
@@ -322,9 +303,6 @@ class TestParse:
 
 
 class TestUseArgs:
-    def setup_method(self, method):
-        parser.clear_cache()
-
     def test_it_should_pass_parsed_as_first_argument(self):
         class Handler:
             request = make_json_request({"key": "value"})

Re-factor cache invalidation
https://github.com/marshmallow-code/webargs/issues/371#issuecomment-471578852
tests/test_tornadoparser.py::TestJSONArgs::test_it_should_get_multiple_values tests/test_tornadoparser.py::TestJSONArgs::test_it_should_get_multiple_nested_values tests/test_tornadoparser.py::TestJSONArgs::test_it_should_not_include_fieldnames_if_not_present tests/test_tornadoparser.py::TestJSONArgs::test_it_should_handle_type_error_on_load_json tests/test_tornadoparser.py::TestJSONArgs::test_it_should_handle_value_error_on_parse_json
tests/test_flaskparser.py::TestFlaskParser::test_parse_querystring_args tests/test_flaskparser.py::TestFlaskParser::test_parse_form tests/test_flaskparser.py::TestFlaskParser::test_parse_json tests/test_flaskparser.py::TestFlaskParser::test_parse_json_missing tests/test_flaskparser.py::TestFlaskParser::test_parse_json_or_form tests/test_flaskparser.py::TestFlaskParser::test_parse_querystring_default tests/test_flaskparser.py::TestFlaskParser::test_parse_json_default tests/test_flaskparser.py::TestFlaskParser::test_parse_json_with_charset tests/test_flaskparser.py::TestFlaskParser::test_parse_json_with_vendor_media_type tests/test_flaskparser.py::TestFlaskParser::test_parse_ignore_extra_data tests/test_flaskparser.py::TestFlaskParser::test_parse_json_empty tests/test_flaskparser.py::TestFlaskParser::test_parse_json_error_unexpected_int tests/test_flaskparser.py::TestFlaskParser::test_parse_json_error_unexpected_list tests/test_flaskparser.py::TestFlaskParser::test_parse_json_many_schema_invalid_input tests/test_flaskparser.py::TestFlaskParser::test_parse_json_many_schema tests/test_flaskparser.py::TestFlaskParser::test_parse_json_many_schema_error_malformed_data tests/test_flaskparser.py::TestFlaskParser::test_parsing_form_default tests/test_flaskparser.py::TestFlaskParser::test_parse_querystring_multiple tests/test_flaskparser.py::TestFlaskParser::test_parse_querystring_multiple_single_value tests/test_flaskparser.py::TestFlaskParser::test_parse_form_multiple tests/test_flaskparser.py::TestFlaskParser::test_parse_json_list tests/test_flaskparser.py::TestFlaskParser::test_parse_json_list_error_malformed_data tests/test_flaskparser.py::TestFlaskParser::test_parse_json_with_nonascii_chars tests/test_flaskparser.py::TestFlaskParser::test_parse_json_with_nonutf8_chars tests/test_flaskparser.py::TestFlaskParser::test_validation_error_returns_422_response tests/test_flaskparser.py::TestFlaskParser::test_user_validation_error_returns_422_response_by_default tests/test_flaskparser.py::TestFlaskParser::test_use_args_decorator tests/test_flaskparser.py::TestFlaskParser::test_use_args_with_path_param tests/test_flaskparser.py::TestFlaskParser::test_use_args_with_validation tests/test_flaskparser.py::TestFlaskParser::test_use_kwargs_decorator tests/test_flaskparser.py::TestFlaskParser::test_use_kwargs_with_path_param tests/test_flaskparser.py::TestFlaskParser::test_parsing_headers tests/test_flaskparser.py::TestFlaskParser::test_parsing_cookies tests/test_flaskparser.py::TestFlaskParser::test_parse_nested_json tests/test_flaskparser.py::TestFlaskParser::test_parse_nested_many_json tests/test_flaskparser.py::TestFlaskParser::test_parse_nested_many_missing tests/test_flaskparser.py::TestFlaskParser::test_parse_files tests/test_flaskparser.py::TestFlaskParser::test_empty_json tests/test_flaskparser.py::TestFlaskParser::test_empty_json_with_headers tests/test_flaskparser.py::TestFlaskParser::test_invalid_json tests/test_flaskparser.py::TestFlaskParser::test_content_type_mismatch[/echo_json-{"name": tests/test_flaskparser.py::TestFlaskParser::test_content_type_mismatch[/echo_form-payload1-application/json] tests/test_flaskparser.py::TestFlaskParser::test_parsing_view_args tests/test_flaskparser.py::TestFlaskParser::test_parsing_invalid_view_arg tests/test_flaskparser.py::TestFlaskParser::test_use_args_with_view_args_parsing tests/test_flaskparser.py::TestFlaskParser::test_use_args_on_a_method_view tests/test_flaskparser.py::TestFlaskParser::test_use_kwargs_on_a_method_view tests/test_flaskparser.py::TestFlaskParser::test_use_kwargs_with_missing_data tests/test_flaskparser.py::TestFlaskParser::test_nested_many_with_data_key tests/test_flaskparser.py::test_abort_called_on_validation_error tests/test_flaskparser.py::test_load_json_returns_missing_if_no_data[None] tests/test_flaskparser.py::test_load_json_returns_missing_if_no_data[application/json] tests/test_flaskparser.py::test_abort_with_message tests/test_flaskparser.py::test_abort_has_serializable_data tests/test_tornadoparser.py::test_tornado_multidictproxy tests/test_tornadoparser.py::TestQueryArgs::test_it_should_get_single_values tests/test_tornadoparser.py::TestQueryArgs::test_it_should_get_multiple_values tests/test_tornadoparser.py::TestQueryArgs::test_it_should_return_missing_if_not_present tests/test_tornadoparser.py::TestFormArgs::test_it_should_get_single_values tests/test_tornadoparser.py::TestFormArgs::test_it_should_get_multiple_values tests/test_tornadoparser.py::TestFormArgs::test_it_should_return_missing_if_not_present tests/test_tornadoparser.py::TestJSONArgs::test_it_should_get_single_values tests/test_tornadoparser.py::TestJSONArgs::test_parsing_request_with_vendor_content_type tests/test_tornadoparser.py::TestHeadersArgs::test_it_should_get_single_values tests/test_tornadoparser.py::TestHeadersArgs::test_it_should_get_multiple_values tests/test_tornadoparser.py::TestHeadersArgs::test_it_should_return_missing_if_not_present tests/test_tornadoparser.py::TestFilesArgs::test_it_should_get_single_values tests/test_tornadoparser.py::TestFilesArgs::test_it_should_get_multiple_values tests/test_tornadoparser.py::TestFilesArgs::test_it_should_return_missing_if_not_present tests/test_tornadoparser.py::TestErrorHandler::test_it_should_raise_httperror_on_failed_validation tests/test_tornadoparser.py::TestParse::test_it_should_parse_query_arguments tests/test_tornadoparser.py::TestParse::test_it_should_parse_form_arguments tests/test_tornadoparser.py::TestParse::test_it_should_parse_json_arguments tests/test_tornadoparser.py::TestParse::test_it_should_raise_when_json_is_invalid tests/test_tornadoparser.py::TestParse::test_it_should_parse_header_arguments tests/test_tornadoparser.py::TestParse::test_it_should_parse_cookies_arguments tests/test_tornadoparser.py::TestParse::test_it_should_parse_files_arguments tests/test_tornadoparser.py::TestParse::test_it_should_parse_required_arguments tests/test_tornadoparser.py::TestParse::test_it_should_parse_multiple_arg_required tests/test_tornadoparser.py::TestUseArgs::test_it_should_pass_parsed_as_first_argument tests/test_tornadoparser.py::TestUseArgs::test_it_should_pass_parsed_as_kwargs_arguments tests/test_tornadoparser.py::TestUseArgs::test_it_should_be_validate_arguments_when_validator_is_passed tests/test_tornadoparser.py::TestApp::test_get_path_param tests/test_tornadoparser.py::TestApp::test_get_with_no_json_body tests/test_tornadoparser.py::TestApp::test_post tests/test_tornadoparser.py::TestValidateApp::test_missing_required_field_throws_422 tests/test_tornadoparser.py::TestValidateApp::test_required_field_provided tests/test_tornadoparser.py::TestValidateApp::test_use_kwargs_with_error tests/test_tornadoparser.py::TestValidateApp::test_user_validator_returns_422_by_default