diff --git a/CHANGES.rst b/CHANGES.rst
index c5c428a..56c8e76 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -16,6 +16,18 @@ Development version
   worker processes in case of a crash.
   https://github.com/joblib/joblib/pull/1269
 
+- Fix memory alignment bug for pickles containing numpy arrays.
+  This is especially important when loading the pickle with
+  ``mmap_mode != None`` as the resulting ``numpy.memmap`` object
+  would not be able to correct the misalignment without performing
+  a memory copy.
+  This bug would cause invalid computation and segmentation faults
+  with native code that would directly access the underlying data
+  buffer of a numpy array, for instance C/C++/Cython code compiled
+  with older GCC versions or some old OpenBLAS written in platform
+  specific assembly.
+  https://github.com/joblib/joblib/pull/1254
+
 Release 1.1.0
 --------------
 
diff --git a/joblib/numpy_pickle.py b/joblib/numpy_pickle.py
index 881d1f0..fa450fb 100644
--- a/joblib/numpy_pickle.py
+++ b/joblib/numpy_pickle.py
@@ -7,6 +7,7 @@
 import pickle
 import os
 import warnings
+import io
 from pathlib import Path
 
 from .compressor import lz4, LZ4_NOT_INSTALLED_ERROR
@@ -39,6 +40,11 @@ register_compressor('lz4', LZ4CompressorWrapper())
 ###############################################################################
 # Utility objects for persistence.
 
+# For convenience, 16 bytes are used to be sure to cover all the possible
+# dtypes' alignments. For reference, see:
+# https://numpy.org/devdocs/dev/alignment.html
+NUMPY_ARRAY_ALIGNMENT_BYTES = 16
+
 
 class NumpyArrayWrapper(object):
     """An object to be persisted instead of numpy arrays.
@@ -70,13 +76,23 @@ class NumpyArrayWrapper(object):
         Default: False.
     """
 
-    def __init__(self, subclass, shape, order, dtype, allow_mmap=False):
+    def __init__(self, subclass, shape, order, dtype, allow_mmap=False,
+                 numpy_array_alignment_bytes=NUMPY_ARRAY_ALIGNMENT_BYTES):
         """Constructor. Store the useful information for later."""
         self.subclass = subclass
         self.shape = shape
         self.order = order
         self.dtype = dtype
         self.allow_mmap = allow_mmap
+        # We make numpy_array_alignment_bytes an instance attribute to allow us
+        # to change our mind about the default alignment and still load the old
+        # pickles (with the previous alignment) correctly
+        self.numpy_array_alignment_bytes = numpy_array_alignment_bytes
+
+    def safe_get_numpy_array_alignment_bytes(self):
+        # NumpyArrayWrapper instances loaded from joblib <= 1.1 pickles don't
+        # have an numpy_array_alignment_bytes attribute
+        return getattr(self, 'numpy_array_alignment_bytes', None)
 
     def write_array(self, array, pickler):
         """Write array bytes to pickler file handle.
@@ -92,6 +108,23 @@ class NumpyArrayWrapper(object):
             # pickle protocol.
             pickle.dump(array, pickler.file_handle, protocol=2)
         else:
+            numpy_array_alignment_bytes = \
+                self.safe_get_numpy_array_alignment_bytes()
+            if numpy_array_alignment_bytes is not None:
+                current_pos = pickler.file_handle.tell()
+                pos_after_padding_byte = current_pos + 1
+                padding_length = numpy_array_alignment_bytes - (
+                    pos_after_padding_byte % numpy_array_alignment_bytes)
+                # A single byte is written that contains the padding length in
+                # bytes
+                padding_length_byte = int.to_bytes(
+                    padding_length, length=1, byteorder='little')
+                pickler.file_handle.write(padding_length_byte)
+
+                if padding_length != 0:
+                    padding = b'\xff' * padding_length
+                    pickler.file_handle.write(padding)
+
             for chunk in pickler.np.nditer(array,
                                            flags=['external_loop',
                                                   'buffered',
@@ -118,6 +151,15 @@ class NumpyArrayWrapper(object):
             # The array contained Python objects. We need to unpickle the data.
             array = pickle.load(unpickler.file_handle)
         else:
+            numpy_array_alignment_bytes = \
+                self.safe_get_numpy_array_alignment_bytes()
+            if numpy_array_alignment_bytes is not None:
+                padding_byte = unpickler.file_handle.read(1)
+                padding_length = int.from_bytes(
+                    padding_byte, byteorder='little')
+                if padding_length != 0:
+                    unpickler.file_handle.read(padding_length)
+
             # This is not a real file. We have to read it the
             # memory-intensive way.
             # crc32 module fails on reads greater than 2 ** 32 bytes,
@@ -150,7 +192,17 @@ class NumpyArrayWrapper(object):
 
     def read_mmap(self, unpickler):
         """Read an array using numpy memmap."""
-        offset = unpickler.file_handle.tell()
+        current_pos = unpickler.file_handle.tell()
+        offset = current_pos
+        numpy_array_alignment_bytes = \
+            self.safe_get_numpy_array_alignment_bytes()
+
+        if numpy_array_alignment_bytes is not None:
+            padding_byte = unpickler.file_handle.read(1)
+            padding_length = int.from_bytes(padding_byte, byteorder='little')
+            # + 1 is for the padding byte
+            offset += padding_length + 1
+
         if unpickler.mmap_mode == 'w+':
             unpickler.mmap_mode = 'r+'
 
@@ -163,6 +215,20 @@ class NumpyArrayWrapper(object):
         # update the offset so that it corresponds to the end of the read array
         unpickler.file_handle.seek(offset + marray.nbytes)
 
+        if (numpy_array_alignment_bytes is None and
+                current_pos % NUMPY_ARRAY_ALIGNMENT_BYTES != 0):
+            message = (
+                f'The memmapped array {marray} loaded from the file '
+                f'{unpickler.file_handle.name} is not not bytes aligned. '
+                'This may cause segmentation faults if this memmapped array '
+                'is used in some libraries like BLAS or PyTorch. '
+                'To get rid of this warning, regenerate your pickle file '
+                'with joblib >= 1.2.0. '
+                'See https://github.com/joblib/joblib/issues/563 '
+                'for more details'
+            )
+            warnings.warn(message)
+
         return marray
 
     def read(self, unpickler):
@@ -239,9 +305,17 @@ class NumpyPickler(Pickler):
         order = 'F' if (array.flags.f_contiguous and
                         not array.flags.c_contiguous) else 'C'
         allow_mmap = not self.buffered and not array.dtype.hasobject
+
+        kwargs = {}
+        try:
+            self.file_handle.tell()
+        except io.UnsupportedOperation:
+            kwargs = {'numpy_array_alignment_bytes': None}
+
         wrapper = NumpyArrayWrapper(type(array),
                                     array.shape, order, array.dtype,
-                                    allow_mmap=allow_mmap)
+                                    allow_mmap=allow_mmap,
+                                    **kwargs)
 
         return wrapper
 

diff --git a/joblib/test/test_numpy_pickle.py b/joblib/test/test_numpy_pickle.py
index 8019ca5..cce16e3 100644
--- a/joblib/test/test_numpy_pickle.py
+++ b/joblib/test/test_numpy_pickle.py
@@ -370,7 +370,7 @@ def test_compressed_pickle_dump_and_load(tmpdir):
             assert result == expected
 
 
-def _check_pickle(filename, expected_list):
+def _check_pickle(filename, expected_list, mmap_mode=None):
     """Helper function to test joblib pickle content.
 
     Note: currently only pickles containing an iterable are supported
@@ -390,17 +390,36 @@ def _check_pickle(filename, expected_list):
                 warnings.filterwarnings(
                     'ignore', module='numpy',
                     message='The compiler package is deprecated')
-                result_list = numpy_pickle.load(filename)
+                result_list = numpy_pickle.load(filename, mmap_mode=mmap_mode)
             filename_base = os.path.basename(filename)
-            expected_nb_warnings = 1 if ("_0.9" in filename_base or
-                                         "_0.8.4" in filename_base) else 0
+            expected_nb_deprecation_warnings = 1 if (
+                "_0.9" in filename_base or "_0.8.4" in filename_base) else 0
+
+            expected_nb_user_warnings = 3 if (
+                re.search("_0.1.+.pkl$", filename_base) and
+                mmap_mode is not None) else 0
+            expected_nb_warnings = \
+                expected_nb_deprecation_warnings + expected_nb_user_warnings
             assert len(warninfo) == expected_nb_warnings
-            for w in warninfo:
-                assert w.category == DeprecationWarning
+
+            deprecation_warnings = [
+                w for w in warninfo if issubclass(
+                    w.category, DeprecationWarning)]
+            user_warnings = [
+                w for w in warninfo if issubclass(
+                    w.category, UserWarning)]
+            for w in deprecation_warnings:
                 assert (str(w.message) ==
                         "The file '{0}' has been generated with a joblib "
                         "version less than 0.10. Please regenerate this "
                         "pickle file.".format(filename))
+
+            for w in user_warnings:
+                escaped_filename = re.escape(filename)
+                assert re.search(
+                    f"memmapped.+{escaped_filename}.+segmentation fault",
+                    str(w.message))
+
             for result, expected in zip(result_list, expected_list):
                 if isinstance(expected, np.ndarray):
                     expected = _ensure_native_byte_order(expected)
@@ -467,6 +486,27 @@ def test_joblib_pickle_across_python_versions():
         _check_pickle(fname, expected_list)
 
 
+@with_numpy
+def test_joblib_pickle_across_python_versions_with_mmap():
+    expected_list = [np.arange(5, dtype=np.dtype('<i8')),
+                     np.arange(5, dtype=np.dtype('<f8')),
+                     np.array([1, 'abc', {'a': 1, 'b': 2}], dtype='O'),
+                     np.arange(256, dtype=np.uint8).tobytes(),
+                     # np.matrix is a subclass of np.ndarray, here we want
+                     # to verify this type of object is correctly unpickled
+                     # among versions.
+                     np.matrix([0, 1, 2], dtype=np.dtype('<i8')),
+                     u"C'est l'\xe9t\xe9 !"]
+
+    test_data_dir = os.path.dirname(os.path.abspath(data.__file__))
+
+    pickle_filenames = [
+        os.path.join(test_data_dir, fn)
+        for fn in os.listdir(test_data_dir) if fn.endswith('.pkl')]
+    for fname in pickle_filenames:
+        _check_pickle(fname, expected_list, mmap_mode='r')
+
+
 @with_numpy
 def test_numpy_array_byte_order_mismatch_detection():
     # List of numpy arrays with big endian byteorder.
@@ -916,6 +956,17 @@ def test_pickle_in_socket():
 
     np.testing.assert_array_equal(array_reloaded, test_array)
 
+    # Check that a byte-aligned numpy array written in a file can be send over
+    # a socket and then read on the other side
+    bytes_to_send = io.BytesIO()
+    numpy_pickle.dump(test_array, bytes_to_send)
+    server.send(bytes_to_send.getvalue())
+
+    with client.makefile("rb") as cf:
+        array_reloaded = numpy_pickle.load(cf)
+
+    np.testing.assert_array_equal(array_reloaded, test_array)
+
 
 @with_numpy
 def test_load_memmap_with_big_offset(tmpdir):
@@ -1056,3 +1107,65 @@ def test_lz4_compression_without_lz4(tmpdir):
     with raises(ValueError) as excinfo:
         numpy_pickle.dump(data, fname + '.lz4')
     excinfo.match(msg)
+
+
+protocols = [pickle.DEFAULT_PROTOCOL]
+if pickle.HIGHEST_PROTOCOL != pickle.DEFAULT_PROTOCOL:
+    protocols.append(pickle.HIGHEST_PROTOCOL)
+
+
+@with_numpy
+@parametrize('protocol', protocols)
+def test_memmap_alignment_padding(tmpdir, protocol):
+    # Test that memmaped arrays returned by numpy.load are correctly aligned
+    fname = tmpdir.join('test.mmap').strpath
+
+    a = np.random.randn(2)
+    numpy_pickle.dump(a, fname, protocol=protocol)
+    memmap = numpy_pickle.load(fname, mmap_mode='r')
+    assert isinstance(memmap, np.memmap)
+    np.testing.assert_array_equal(a, memmap)
+    assert (
+        memmap.ctypes.data % numpy_pickle.NUMPY_ARRAY_ALIGNMENT_BYTES == 0)
+    assert memmap.flags.aligned
+
+    array_list = [
+        np.random.randn(2), np.random.randn(2),
+        np.random.randn(2), np.random.randn(2)
+    ]
+
+    # On Windows OSError 22 if reusing the same path for memmap ...
+    fname = tmpdir.join('test1.mmap').strpath
+    numpy_pickle.dump(array_list, fname, protocol=protocol)
+    l_reloaded = numpy_pickle.load(fname, mmap_mode='r')
+
+    for idx, memmap in enumerate(l_reloaded):
+        assert isinstance(memmap, np.memmap)
+        np.testing.assert_array_equal(array_list[idx], memmap)
+        assert (
+            memmap.ctypes.data % numpy_pickle.NUMPY_ARRAY_ALIGNMENT_BYTES == 0)
+        assert memmap.flags.aligned
+
+    array_dict = {
+        'a0': np.arange(2, dtype=np.uint8),
+        'a1': np.arange(3, dtype=np.uint8),
+        'a2': np.arange(5, dtype=np.uint8),
+        'a3': np.arange(7, dtype=np.uint8),
+        'a4': np.arange(11, dtype=np.uint8),
+        'a5': np.arange(13, dtype=np.uint8),
+        'a6': np.arange(17, dtype=np.uint8),
+        'a7': np.arange(19, dtype=np.uint8),
+        'a8': np.arange(23, dtype=np.uint8),
+    }
+
+    # On Windows OSError 22 if reusing the same path for memmap ...
+    fname = tmpdir.join('test2.mmap').strpath
+    numpy_pickle.dump(array_dict, fname, protocol=protocol)
+    d_reloaded = numpy_pickle.load(fname, mmap_mode='r')
+
+    for key, memmap in d_reloaded.items():
+        assert isinstance(memmap, np.memmap)
+        np.testing.assert_array_equal(array_dict[key], memmap)
+        assert (
+            memmap.ctypes.data % numpy_pickle.NUMPY_ARRAY_ALIGNMENT_BYTES == 0)
+        assert memmap.flags.aligned

Alignment issue when passing arrays though mmap
Arrays that are transfered to subprocesses though mmap appear not always to be aligned:

```python
import joblib
import numpy as np

def func(x):
    print(type(x))
    print(x.flags)
    print(x.ctypes.data / 8)

if __name__ == '__main__':
    # Make the array larger than 1Mbyte so that mmap is used
    n = 1024 ** 2 // 8 + 1
    x = np.random.randn(n)
    jobs = joblib.Parallel(2)
    print(x.nbytes)
    res = jobs([joblib.delayed(func)(x), joblib.delayed(func)(x)])
```

This returns
```
<class 'numpy.core.memmap.memmap'>
1048584
  C_CONTIGUOUS : True
  F_CONTIGUOUS : True
  OWNDATA : False
  WRITEABLE : False
  ALIGNED : False
  UPDATEIFCOPY : False
570054683.375
```

Note the last line, the address of the first element of the array is indeed not aligned.

I'm using version 0.11, on OSx sierra.

This came up in https://github.com/pymc-devs/pymc3/issues/2640, and seems to happen on several OSs.
joblib/test/test_numpy_pickle.py::test_memmap_alignment_padding[5] joblib/test/test_numpy_pickle.py::test_memmap_alignment_padding[4]
joblib/test/test_numpy_pickle.py::test_file_handle_persistence_in_memory_mmap joblib/test/test_numpy_pickle.py::test_numpy_subclass joblib/test/test_numpy_pickle.py::test_standard_types[member15-0] joblib/test/test_numpy_pickle.py::test_standard_types[type-0] joblib/test/test_numpy_pickle.py::test_pathlib joblib/test/test_numpy_pickle.py::test_compress_level_error[-1] joblib/test/test_numpy_pickle.py::test_compress_mmap_mode_warning joblib/test/test_numpy_pickle.py::test_compress_string_argument[gzip] joblib/test/test_numpy_pickle.py::test_standard_types[1_0-1] joblib/test/test_numpy_pickle.py::test_register_compressor joblib/test/test_numpy_pickle.py::test_compress_level_error[wrong_compress2] joblib/test/test_numpy_pickle.py::test_compress_level_error[10] joblib/test/test_numpy_pickle.py::test_non_contiguous_array_pickling joblib/test/test_numpy_pickle.py::test_compress_string_argument[zlib] joblib/test/test_numpy_pickle.py::test_standard_types[None-0] joblib/test/test_numpy_pickle.py::test_in_memory_persistence joblib/test/test_numpy_pickle.py::test_binary_zlibfile_invalid_modes[x] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[bz2-6] joblib/test/test_numpy_pickle.py::test_compression_using_file_extension[.bz2-bz2] joblib/test/test_numpy_pickle.py::test_compression_using_file_extension[.z-zlib] joblib/test/test_numpy_pickle.py::test_binary_zlibfile_invalid_modes[w] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[bz2-3] joblib/test/test_numpy_pickle.py::test_standard_types[1_1-1] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[gzip-6] joblib/test/test_numpy_pickle.py::test_standard_types[member15-1] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[lzma-1] joblib/test/test_numpy_pickle.py::test_binary_zlibfile[3-a joblib/test/test_numpy_pickle.py::test_standard_types[len-0] joblib/test/test_numpy_pickle.py::test_compress_tuple_argument_exception[compress_tuple1-Non joblib/test/test_numpy_pickle.py::test_binary_zlibfile_bad_compression_levels[-1] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[zlib-6] joblib/test/test_numpy_pickle.py::test_binary_zlibfile_invalid_filename_type[bad_file1] joblib/test/test_numpy_pickle.py::test_binary_zlibfile[1-a joblib/test/test_numpy_pickle.py::test_standard_types[_newclass-1] joblib/test/test_numpy_pickle.py::test_standard_types[type-1] joblib/test/test_numpy_pickle.py::test_standard_types[1_1-0] joblib/test/test_numpy_pickle.py::test_binary_zlibfile_invalid_modes[1] joblib/test/test_numpy_pickle.py::test_compress_tuple_argument[compress_tuple0] joblib/test/test_numpy_pickle.py::test_standard_types[1_0-0] joblib/test/test_numpy_pickle.py::test_standard_types[member8-1] joblib/test/test_numpy_pickle.py::test_binary_zlibfile_invalid_modes[2] joblib/test/test_numpy_pickle.py::test_standard_types[len-1] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[gzip-3] joblib/test/test_numpy_pickle.py::test_memmap_persistence_mixed_dtypes joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[lzma-6] joblib/test/test_numpy_pickle.py::test_file_handle_persistence_mmap joblib/test/test_numpy_pickle.py::test_compress_tuple_argument_exception[compress_tuple0-Compress joblib/test/test_numpy_pickle.py::test_register_compressor_invalid_fileobj joblib/test/test_numpy_pickle.py::test_compression_using_file_extension[.xz-xz] joblib/test/test_numpy_pickle.py::test_compress_tuple_argument_exception[compress_tuple2-Non joblib/test/test_numpy_pickle.py::test_pickle_highest_protocol joblib/test/test_numpy_pickle.py::test_standard_types[member7-0] joblib/test/test_numpy_pickle.py::test_standard_types[True-0] joblib/test/test_numpy_pickle.py::test_masked_array_persistence joblib/test/test_numpy_pickle.py::test_file_handle_persistence_compressed_mmap joblib/test/test_numpy_pickle.py::test_standard_types[_function-1] joblib/test/test_numpy_pickle.py::test_standard_types[member14-0] joblib/test/test_numpy_pickle.py::test_numpy_persistence[False] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[xz-1] joblib/test/test_numpy_pickle.py::test_numpy_persistence[3] joblib/test/test_numpy_pickle.py::test_file_handle_persistence joblib/test/test_numpy_pickle.py::test_binary_zlibfile_bad_compression_levels[bad_value5] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[gzip-1] joblib/test/test_numpy_pickle.py::test_compression_using_file_extension[.lzma-lzma] joblib/test/test_numpy_pickle.py::test_binary_zlibfile[9-a joblib/test/test_numpy_pickle.py::test_standard_types[member9-1] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[bz2-1] joblib/test/test_numpy_pickle.py::test_standard_types[member8-0] joblib/test/test_numpy_pickle.py::test_binary_zlibfile_invalid_modes[a] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[zlib-1] joblib/test/test_numpy_pickle.py::test_standard_types[member14-1] joblib/test/test_numpy_pickle.py::test_compress_tuple_argument[compress_tuple1] joblib/test/test_numpy_pickle.py::test_register_compressor_already_registered joblib/test/test_numpy_pickle.py::test_binary_zlibfile_bad_compression_levels[bad_value4] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[zlib-3] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[xz-3] joblib/test/test_numpy_pickle.py::test_binary_zlibfile_invalid_modes[r] joblib/test/test_numpy_pickle.py::test_standard_types[_newclass-0] joblib/test/test_numpy_pickle.py::test_compression_using_file_extension[-not-compressed] joblib/test/test_numpy_pickle.py::test_binary_zlibfile_invalid_filename_type[bad_file2] joblib/test/test_numpy_pickle.py::test_binary_zlibfile_bad_compression_levels[10] joblib/test/test_numpy_pickle.py::test_standard_types[(1+0j)-0] joblib/test/test_numpy_pickle.py::test_standard_types[(1+0j)-1] joblib/test/test_numpy_pickle.py::test_standard_types[_function-0] joblib/test/test_numpy_pickle.py::test_standard_types[1.0-1] joblib/test/test_numpy_pickle.py::test_numpy_persistence_bufferred_array_compression joblib/test/test_numpy_pickle.py::test_pickle_in_socket joblib/test/test_numpy_pickle.py::test_register_compressor_invalid_name[invalid_name2] joblib/test/test_numpy_pickle.py::test_standard_types[member7-1] joblib/test/test_numpy_pickle.py::test_standard_types[member9-0] joblib/test/test_numpy_pickle.py::test_load_memmap_with_big_offset joblib/test/test_numpy_pickle.py::test_compression_using_file_extension[.pkl-not-compressed] joblib/test/test_numpy_pickle.py::test_numpy_persistence[0] joblib/test/test_numpy_pickle.py::test_load_externally_decompressed_files[.gz-_gzip_file_decompress] joblib/test/test_numpy_pickle.py::test_joblib_compression_formats[xz-6] 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