popV/tabula_muris_All

Popular Vote (popV) model for automated cell type annotation of single-cell RNA-seq data. We provide here pretrained models for plug-in use in your own analysis. Follow our tutorial to learn how to use the model for cell type annotation.

Model description

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood. To gain a better insight into these processes, here we generate a single-cell transcriptomic atlas across the lifespan of Mus musculus that includes data from 23 tissues and organs. We found cell-specific changes occurring across multiple cell types and organs, as well as age-related changes in the cellular composition of different organs. Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing—such as senescence, genomic instability and changes in the immune system. This transcriptomic atlas—which we denote Tabula Muris Senis, or ‘Mouse Ageing Cell Atlas’—provides molecular information about how the most important hallmarks of ageing are reflected in a broad range of tissues and cell types.

Link to CELLxGENE: Link to the data in the CELLxGENE browser for interactive exploration of the data and download of the source data.

Training Code URL: Not provided by uploader.

Metrics

We provide here accuracies for each of the experts and the ensemble model. The validation set accuracies are computed on a 10% random subset of the data that was not used for training.

Cell Type	N cells	celltypist	knn bbknn	knn harmony	knn on scvi	onclass	scanvi	svm	xgboost	Consensus Prediction
B cell	3640	0.86	0.90	0.86	0.87	0.00	0.87	0.72	0.79	0.91
mesenchymal stem cell	1646	0.87	0.88	0.87	0.75	0.00	0.66	0.91	0.86	0.93
basal cell of epidermis	1572	0.86	0.87	0.82	0.87	0.00	0.83	0.86	0.83	0.91
granulocyte	1651	0.82	0.86	0.82	0.80	0.00	0.82	0.74	0.85	0.89
endothelial cell	1404	0.87	0.88	0.82	0.71	0.00	0.70	0.90	0.86	0.91
microglial cell	1326	0.99	0.99	0.95	0.98	0.00	0.97	0.98	0.99	0.99
T cell	1244	0.78	0.80	0.66	0.63	0.00	0.73	0.65	0.74	0.81
keratinocyte	1231	0.85	0.88	0.80	0.86	0.00	0.81	0.88	0.86	0.91
macrophage	979	0.41	0.67	0.61	0.53	0.00	0.42	0.51	0.55	0.71
classical monocyte	795	0.81	0.61	0.62	0.65	0.00	0.77	0.80	0.82	0.90
granulocytopoietic cell	806	0.65	0.80	0.66	0.67	0.00	0.63	0.68	0.80	0.82
bladder urothelial cell	634	0.98	0.98	0.94	0.92	0.00	0.83	0.99	0.98	0.98
mesenchymal stem cell of adipose tissue	610	0.85	0.85	0.69	0.60	0.00	0.59	0.90	0.80	0.89
fibroblast of cardiac tissue	616	0.96	0.95	0.80	0.67	0.00	0.58	0.96	0.92	0.97
endothelial cell of coronary artery	583	0.85	0.88	0.64	0.50	0.00	0.37	0.89	0.85	0.92
skeletal muscle satellite cell	420	0.97	0.97	0.93	0.97	0.00	0.96	0.96	0.94	0.97
proerythroblast	442	0.50	0.53	0.45	0.26	0.00	0.62	0.45	0.65	0.64
kidney proximal convoluted tubule epithelial cell	436	0.86	0.87	0.28	0.81	0.00	0.75	0.87	0.87	0.88
bronchial smooth muscle cell	430	0.93	0.95	0.85	0.84	0.00	0.88	0.95	0.94	0.95
myeloid cell	440	0.51	0.62	0.46	0.51	0.00	0.38	0.70	0.67	0.74
hepatocyte	382	0.99	0.98	0.99	0.98	0.00	0.96	0.99	0.99	0.99
type B pancreatic cell	418	0.97	0.97	0.95	0.97	0.00	0.98	0.98	0.97	0.98
bladder cell	383	0.97	0.96	0.93	0.67	0.00	0.78	0.99	0.95	0.99
promonocyte	387	0.71	0.74	0.73	0.59	0.00	0.67	0.74	0.79	0.84
DN4 thymocyte	338	0.38	0.51	0.32	0.33	0.00	0.17	0.54	0.63	0.53
basal cell	360	0.98	0.97	0.98	0.95	0.00	0.92	0.98	0.96	0.98
monocyte	393	0.64	0.58	0.56	0.33	0.00	0.56	0.76	0.75	0.82
enterocyte of epithelium of large intestine	403	0.90	0.93	0.84	0.91	0.00	0.90	0.93	0.92	0.94
thymocyte	372	0.74	0.74	0.65	0.83	0.00	0.80	0.88	0.91	0.86
epithelial cell of proximal tubule	298	0.82	0.81	0.73	0.71	0.00	0.76	0.80	0.80	0.83
natural killer cell	330	0.85	0.85	0.72	0.74	0.00	0.79	0.78	0.83	0.85
naive B cell	342	0.46	0.25	0.55	0.47	0.00	0.48	0.49	0.51	0.61
hematopoietic stem cell	342	0.90	0.93	0.89	0.90	0.00	0.88	0.94	0.93	0.94
mature NK T cell	324	0.63	0.66	0.49	0.18	0.00	0.52	0.56	0.68	0.71
fibroblast	307	0.45	0.24	0.46	0.47	0.00	0.26	0.62	0.60	0.64
stromal cell	340	0.74	0.53	0.70	0.32	0.00	0.35	0.89	0.73	0.87
keratinocyte stem cell	301	0.94	0.92	0.86	0.90	0.00	0.85	0.93	0.91	0.94
erythroblast	266	0.65	0.69	0.68	0.56	0.00	0.62	0.69	0.74	0.80
Kupffer cell	292	0.97	0.93	0.73	0.56	0.00	0.90	0.97	0.97	0.98
megakaryocyte-erythroid progenitor cell	250	0.57	0.63	0.56	0.52	0.00	0.62	0.61	0.69	0.75
pancreatic acinar cell	280	0.95	0.93	0.95	0.97	0.00	0.98	0.99	0.97	0.99
luminal epithelial cell of mammary gland	261	0.93	0.93	0.94	0.79	0.00	0.89	0.95	0.93	0.97
professional antigen presenting cell	221	0.03	0.01	0.08	0.00	0.00	0.00	0.35	0.35	0.05
epidermal cell	249	0.87	0.87	0.81	0.81	0.00	0.85	0.89	0.85	0.90
hematopoietic precursor cell	217	0.64	0.76	0.42	0.34	0.00	0.40	0.69	0.75	0.82
oligodendrocyte	201	0.97	0.97	0.95	0.97	0.00	0.98	0.99	0.98	0.98
fibroblast of lung	188	0.96	0.96	0.93	0.92	0.00	0.95	0.98	0.95	0.97
CD8-positive, alpha-beta T cell	201	0.43	0.50	0.31	0.31	0.00	0.44	0.45	0.58	0.59
epithelial cell of large intestine	214	0.82	0.83	0.56	0.78	0.00	0.79	0.85	0.84	0.87
intestinal crypt stem cell	192	0.84	0.88	0.65	0.83	0.00	0.83	0.87	0.84	0.90
chondrocyte	185	0.72	0.62	0.75	0.63	0.00	0.73	0.83	0.78	0.78
immature T cell	187	0.72	0.00	0.13	0.61	0.00	0.53	0.83	0.86	0.72
precursor B cell	170	0.71	0.83	0.67	0.72	0.00	0.57	0.79	0.81	0.88
intermediate monocyte	193	0.23	0.03	0.31	0.33	0.00	0.61	0.53	0.56	0.65
large intestine goblet cell	171	0.80	0.85	0.76	0.79	0.00	0.83	0.92	0.86	0.88
CD4-positive, alpha-beta T cell	172	0.00	0.46	0.19	0.27	0.00	0.37	0.39	0.43	0.50
smooth muscle cell	184	0.64	0.80	0.73	0.66	0.00	0.75	0.86	0.82	0.78
leukocyte	167	0.49	0.57	0.31	0.31	0.00	0.27	0.57	0.64	0.73
plasma cell	160	0.51	0.65	0.53	0.40	0.00	0.58	0.52	0.63	0.67
lymphocyte	164	0.26	0.29	0.26	0.12	0.00	0.06	0.23	0.39	0.36
naive T cell	160	0.79	0.86	0.86	0.82	0.00	0.77	0.87	0.85	0.87
kidney loop of Henle thick ascending limb epithelial cell	162	0.91	0.93	0.67	0.76	0.00	0.46	0.92	0.92	0.96
immature B cell	126	0.76	0.73	0.65	0.73	0.00	0.68	0.52	0.60	0.80
alveolar macrophage	132	0.92	0.92	0.82	0.91	0.00	0.95	0.97	0.94	0.96
endothelial cell of hepatic sinusoid	134	0.97	0.96	0.95	0.72	0.00	0.83	0.97	0.96	0.98
lung macrophage	120	0.84	0.08	0.46	0.20	0.00	0.84	0.85	0.78	0.93
non-classical monocyte	140	0.59	0.69	0.58	0.58	0.00	0.71	0.80	0.74	0.77
endocardial cell	100	0.93	0.93	0.92	0.82	0.00	0.87	0.87	0.84	0.91
double negative thymocyte	92	0.62	0.00	0.26	0.13	0.00	0.37	0.69	0.73	0.75
late pro-B cell	91	0.71	0.74	0.46	0.63	0.00	0.49	0.54	0.79	0.83
kidney collecting duct principal cell	114	0.74	0.91	0.81	0.81	0.00	0.88	0.95	0.90	0.95
basal epithelial cell of tracheobronchial tree	87	0.91	0.73	0.84	0.70	0.00	0.57	0.89	0.82	0.95
mesenchymal cell	98	0.31	0.00	0.04	0.06	0.00	0.04	0.48	0.52	0.46
pancreatic A cell	84	0.66	0.72	0.56	0.77	0.00	0.85	0.87	0.86	0.85
adventitial cell	86	0.69	0.62	0.57	0.20	0.00	0.14	0.85	0.54	0.78
epithelial cell	83	0.41	0.12	0.58	0.52	0.00	0.20	0.52	0.63	0.67
kidney distal convoluted tubule epithelial cell	62	0.74	0.85	0.71	0.31	0.00	0.86	0.89	0.82	0.89
neutrophil	78	0.57	0.66	0.39	0.50	0.00	0.47	0.71	0.65	0.74
pancreatic ductal cell	72	0.92	0.76	0.83	0.86	0.00	0.88	0.94	0.88	0.92
myeloid dendritic cell	48	0.36	0.48	0.40	0.40	0.00	0.44	0.63	0.45	0.62
astrocyte	61	0.90	0.94	0.94	0.95	0.00	0.94	0.96	0.89	0.97
secretory cell	56	0.25	0.51	0.37	0.42	0.00	0.69	0.86	0.82	0.73
myeloid leukocyte	57	0.62	0.41	0.46	0.18	0.00	0.27	0.54	0.58	0.78
plasmatocyte	42	0.75	0.78	0.48	0.64	0.00	0.61	0.83	0.77	0.87
neuron	47	0.62	0.64	0.82	0.78	0.00	0.85	0.87	0.79	0.86
brain pericyte	41	0.44	0.79	0.57	0.70	0.00	0.82	0.93	0.87	0.83
vein endothelial cell	57	0.48	0.80	0.62	0.51	0.00	0.79	0.85	0.76	0.86
pancreatic D cell	39	0.00	0.56	0.48	0.86	0.00	0.88	0.91	0.93	0.91
kidney collecting duct epithelial cell	33	0.37	0.60	0.17	0.70	0.00	0.54	0.84	0.77	0.88
aortic endothelial cell	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
brush cell	43	0.84	0.72	0.24	0.79	0.00	0.72	0.81	0.81	0.87
erythroid progenitor cell, mammalian	38	0.49	0.00	0.70	0.16	0.00	0.19	0.69	0.55	0.83
regular atrial cardiac myocyte	32	0.32	0.47	0.32	0.41	0.00	0.38	0.52	0.53	0.62
kidney cortex artery cell	42	0.77	0.85	0.65	0.26	0.00	0.32	0.71	0.61	0.82
erythrocyte	44	0.82	0.64	0.60	0.79	0.00	0.70	0.81	0.86	0.89
mesangial cell	38	0.00	0.79	0.45	0.22	0.00	0.30	0.78	0.63	0.80
kidney loop of Henle ascending limb epithelial cell	23	0.27	0.49	0.29	0.13	0.00	0.27	0.54	0.54	0.69
cardiac muscle cell	42	0.81	0.81	0.72	0.91	0.00	0.89	1.00	0.97	0.99
mature alpha-beta T cell	37	0.00	0.20	0.10	0.38	0.00	0.32	0.38	0.49	0.31
basophil	31	0.54	0.69	0.75	0.58	0.00	0.40	0.67	0.52	0.81
cardiac valve cell	24	0.63	0.71	0.48	0.68	0.00	0.70	0.82	0.73	0.77
oligodendrocyte precursor cell	38	0.97	0.97	0.96	0.97	0.00	0.96	0.99	0.99	0.99
Schwann cell	26	0.74	0.81	0.76	0.75	0.00	0.74	0.80	0.69	0.79
pulmonary interstitial fibroblast	23	0.92	0.85	0.81	0.82	0.00	0.81	0.90	0.94	0.96
smooth muscle cell of trachea	23	0.00	0.29	0.32	0.27	0.00	0.07	0.52	0.52	0.27
granulocyte monocyte progenitor cell	31	0.00	0.63	0.74	0.73	0.00	0.75	0.91	0.85	0.92
interneuron	22	0.51	0.59	0.45	0.68	0.00	0.76	0.89	0.75	0.81
pancreatic PP cell	27	0.00	0.14	0.20	0.59	0.00	0.73	0.75	0.81	0.58
smooth muscle cell of the pulmonary artery	20	0.00	0.62	0.57	0.40	0.00	0.33	0.83	0.77	0.76
cell of skeletal muscle	22	0.89	0.91	0.72	0.93	0.00	0.92	0.89	0.90	0.93
brush cell of epithelium proper of large intestine	15	0.49	0.70	0.22	0.81	0.00	0.67	0.91	0.88	0.83
Langerhans cell	22	0.91	0.86	0.53	0.66	0.00	0.48	0.79	0.83	0.93
stem cell of epidermis	13	0.00	0.00	0.42	0.47	0.00	0.44	0.59	0.42	0.76
regulatory T cell	15	0.00	0.00	0.00	0.00	0.00	0.16	0.17	0.12	0.00
epithelial cell of thymus	19	0.10	0.00	0.23	0.27	0.00	0.06	0.57	0.39	0.25
enteroendocrine cell	13	0.75	0.67	0.56	0.73	0.00	0.86	1.00	0.69	0.83
kidney capillary endothelial cell	16	0.24	0.45	0.48	0.07	0.00	0.34	0.26	0.28	0.34
neuroepithelial stem cell	21	0.25	0.31	0.58	0.52	0.00	0.33	0.87	0.58	0.70
macrophage dendritic cell progenitor	14	0.00	0.38	0.46	0.42	0.00	0.36	0.60	0.47	0.67
DN3 thymocyte	18	0.00	0.10	0.10	0.71	0.00	0.61	0.74	0.67	0.65
regular ventricular cardiac myocyte	6	0.27	0.00	0.36	0.40	0.00	0.71	0.62	0.57	0.67
endothelial cell of lymphatic vessel	6	0.00	0.40	0.91	0.17	0.00	0.16	0.44	0.35	0.62
ciliated columnar cell of tracheobronchial tree	8	0.00	0.76	0.80	0.89	0.00	0.40	1.00	0.93	1.00
plasmacytoid dendritic cell	10	0.00	0.18	0.50	0.00	0.00	0.13	0.55	0.36	0.67
dendritic cell	10	0.00	0.27	0.24	0.18	0.00	0.16	0.41	0.42	0.48
medium spiny neuron	12	0.00	0.59	0.80	0.70	0.00	0.92	1.00	0.92	0.96
pericyte	11	0.88	0.92	0.96	0.73	0.00	0.92	0.85	0.88	0.96
neural stem cell	12	0.29	0.50	0.70	0.91	0.00	0.72	1.00	0.96	0.96
kidney proximal straight tubule epithelial cell	9	0.00	0.00	0.00	0.00	0.00	0.00	0.20	0.26	0.00
blood cell	12	0.31	0.00	0.00	0.00	0.00	0.00	0.36	0.21	0.33
immature NK T cell	11	0.00	0.17	0.25	0.15	0.00	0.15	0.40	0.24	0.53
cardiac neuron	8	0.00	0.00	0.22	0.33	0.00	0.50	0.50	0.44	0.50
mast cell	10	0.00	0.00	0.40	0.27	0.00	0.00	0.56	0.69	0.50
mucus secreting cell	9	0.00	0.40	0.71	0.56	0.00	0.47	0.80	0.84	0.94
early pro-B cell	9	0.00	0.50	0.62	0.50	0.00	0.67	0.63	0.70	0.62
pancreatic stellate cell	12	0.80	0.40	0.50	0.53	0.00	0.13	0.56	0.88	0.86
ependymal cell	8	0.82	0.80	0.93	0.89	0.00	0.76	0.89	0.89	0.94
Bergmann glial cell	6	0.00	0.67	0.67	0.73	0.00	0.71	0.91	0.80	0.91
neuroendocrine cell	4	0.00	0.00	0.00	0.00	0.00	0.00	0.57	0.50	0.00
fibrocyte	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
hepatic stellate cell	2	0.00	1.00	0.67	0.57	0.00	0.22	1.00	0.67	1.00
club cell	2	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
respiratory basal cell	1	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
kidney interstitial fibroblast	2	0.00	0.00	0.00	1.00	0.00	0.15	0.40	0.40	1.00
lymphoid lineage restricted progenitor cell	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
lung neuroendocrine cell	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
kidney cell	0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
duct epithelial cell	1	0.00	0.00	0.00	0.00	0.00	0.00	1.00	0.00	0.00

The train accuracies are computed on the training data.

Cell Type	N cells	celltypist	knn bbknn	knn harmony	knn on scvi	onclass	scanvi	svm	xgboost	Consensus Prediction
B cell	32688	0.85	0.90	0.89	0.93	0.00	0.93	0.73	0.79	0.95
mesenchymal stem cell	14492	0.86	0.86	0.92	0.89	0.00	0.91	0.91	0.85	0.95
basal cell of epidermis	14065	0.85	0.87	0.91	0.92	0.00	0.85	0.86	0.84	0.92
granulocyte	13911	0.80	0.84	0.90	0.91	0.00	0.86	0.74	0.85	0.91
endothelial cell	13412	0.86	0.86	0.87	0.86	0.00	0.86	0.90	0.86	0.95
microglial cell	11942	0.99	0.99	0.95	0.99	0.00	0.97	0.99	0.99	0.99
T cell	11498	0.77	0.79	0.77	0.84	0.00	0.89	0.68	0.75	0.88
keratinocyte	11126	0.86	0.87	0.91	0.93	0.00	0.88	0.89	0.86	0.92
macrophage	8645	0.45	0.63	0.83	0.77	0.00	0.74	0.56	0.60	0.82
classical monocyte	7327	0.83	0.54	0.78	0.90	0.00	0.89	0.82	0.84	0.93
granulocytopoietic cell	7276	0.65	0.79	0.85	0.86	0.00	0.76	0.70	0.81	0.88
bladder urothelial cell	5999	0.98	0.98	0.97	0.97	0.00	0.97	0.99	0.98	0.99
mesenchymal stem cell of adipose tissue	6012	0.81	0.81	0.84	0.76	0.00	0.94	0.90	0.81	0.93
fibroblast of cardiac tissue	5705	0.94	0.93	0.86	0.82	0.00	0.94	0.95	0.92	0.97
endothelial cell of coronary artery	5404	0.82	0.83	0.80	0.79	0.00	0.92	0.91	0.86	0.96
skeletal muscle satellite cell	4356	0.98	0.97	0.95	0.98	0.00	0.96	0.97	0.96	0.98
proerythroblast	4235	0.54	0.52	0.73	0.77	0.00	0.76	0.55	0.69	0.75
kidney proximal convoluted tubule epithelial cell	4024	0.84	0.81	0.89	0.89	0.00	0.87	0.90	0.89	0.92
bronchial smooth muscle cell	4024	0.94	0.96	0.82	0.90	0.00	0.93	0.96	0.95	0.97
myeloid cell	3977	0.51	0.56	0.73	0.70	0.00	0.85	0.72	0.72	0.86
hepatocyte	3690	0.99	0.98	0.98	0.98	0.00	0.97	0.99	0.99	0.99
type B pancreatic cell	3598	0.97	0.97	0.97	0.98	0.00	0.98	0.99	0.98	0.99
bladder cell	3627	0.97	0.95	0.98	0.81	0.00	0.96	0.99	0.94	0.99
promonocyte	3455	0.69	0.70	0.85	0.86	0.00	0.87	0.77	0.81	0.88
DN4 thymocyte	3418	0.35	0.46	0.60	0.68	0.00	0.88	0.63	0.69	0.78
basal cell	3366	0.98	0.97	0.98	0.97	0.00	0.97	0.99	0.97	0.99
monocyte	3281	0.66	0.53	0.77	0.81	0.00	0.86	0.80	0.81	0.90
enterocyte of epithelium of large intestine	3264	0.90	0.92	0.94	0.94	0.00	0.93	0.94	0.94	0.96
thymocyte	3145	0.74	0.75	0.86	0.93	0.00	0.91	0.91	0.92	0.96
epithelial cell of proximal tubule	3138	0.81	0.77	0.86	0.84	0.00	0.87	0.87	0.85	0.89
natural killer cell	3029	0.82	0.80	0.74	0.86	0.00	0.87	0.81	0.84	0.88
naive B cell	3015	0.44	0.20	0.89	0.66	0.00	0.76	0.52	0.56	0.83
hematopoietic stem cell	3000	0.92	0.93	0.94	0.94	0.00	0.92	0.95	0.94	0.96
mature NK T cell	2837	0.60	0.61	0.61	0.79	0.00	0.82	0.64	0.71	0.78
fibroblast	2836	0.46	0.26	0.69	0.66	0.00	0.70	0.67	0.65	0.79
stromal cell	2783	0.68	0.35	0.88	0.75	0.00	0.97	0.88	0.70	0.92
keratinocyte stem cell	2755	0.94	0.92	0.92	0.94	0.00	0.94	0.94	0.91	0.96
erythroblast	2652	0.65	0.69	0.83	0.84	0.00	0.83	0.72	0.77	0.85
Kupffer cell	2515	0.97	0.94	0.88	0.94	0.00	0.97	0.98	0.97	0.99
megakaryocyte-erythroid progenitor cell	2542	0.57	0.64	0.77	0.76	0.00	0.79	0.66	0.74	0.81
pancreatic acinar cell	2436	0.96	0.96	0.95	0.99	0.00	0.98	0.99	0.99	0.99
luminal epithelial cell of mammary gland	2410	0.92	0.91	0.98	0.93	0.00	0.97	0.97	0.94	0.98
professional antigen presenting cell	2381	0.06	0.01	0.30	0.53	0.00	0.92	0.39	0.42	0.56
epidermal cell	1978	0.84	0.86	0.89	0.89	0.00	0.82	0.88	0.85	0.91
hematopoietic precursor cell	1927	0.60	0.71	0.66	0.81	0.00	0.91	0.73	0.81	0.89
oligodendrocyte	1893	0.98	0.99	0.97	0.99	0.00	0.99	1.00	0.99	0.99
fibroblast of lung	1816	0.96	0.95	0.92	0.94	0.00	0.97	0.99	0.97	0.98
CD8-positive, alpha-beta T cell	1739	0.46	0.49	0.51	0.64	0.00	0.66	0.58	0.65	0.73
epithelial cell of large intestine	1719	0.78	0.78	0.85	0.83	0.00	0.84	0.88	0.87	0.89
intestinal crypt stem cell	1726	0.81	0.85	0.89	0.90	0.00	0.88	0.90	0.88	0.92
chondrocyte	1720	0.75	0.62	0.85	0.84	0.00	0.87	0.89	0.88	0.86
immature T cell	1597	0.71	0.00	0.83	0.94	0.00	0.93	0.87	0.90	0.96
precursor B cell	1601	0.71	0.86	0.93	0.89	0.00	0.89	0.84	0.89	0.93
intermediate monocyte	1568	0.19	0.04	0.48	0.67	0.00	0.68	0.58	0.60	0.75
large intestine goblet cell	1574	0.81	0.84	0.92	0.87	0.00	0.93	0.95	0.92	0.95
CD4-positive, alpha-beta T cell	1549	0.00	0.39	0.47	0.59	0.00	0.64	0.49	0.60	0.74
smooth muscle cell	1520	0.64	0.75	0.83	0.89	0.00	0.87	0.88	0.84	0.84
leukocyte	1491	0.48	0.49	0.70	0.66	0.00	0.79	0.61	0.70	0.91
plasma cell	1486	0.52	0.62	0.81	0.81	0.00	0.80	0.57	0.68	0.80
lymphocyte	1437	0.23	0.22	0.67	0.60	0.00	0.85	0.32	0.49	0.73
naive T cell	1408	0.79	0.86	0.93	0.92	0.00	0.81	0.90	0.88	0.90
kidney loop of Henle thick ascending limb epithelial cell	1392	0.90	0.91	0.93	0.85	0.00	0.92	0.96	0.96	0.96
immature B cell	1289	0.80	0.71	0.82	0.81	0.00	0.82	0.62	0.72	0.90
alveolar macrophage	1234	0.94	0.94	0.93	0.94	0.00	0.96	0.98	0.95	0.98
endothelial cell of hepatic sinusoid	1156	0.95	0.94	0.87	0.85	0.00	0.87	0.97	0.96	0.98
lung macrophage	1046	0.84	0.04	0.72	0.91	0.00	0.94	0.91	0.87	0.96
non-classical monocyte	1018	0.53	0.64	0.83	0.83	0.00	0.91	0.81	0.78	0.83
endocardial cell	953	0.92	0.92	0.94	0.87	0.00	0.92	0.92	0.85	0.96
double negative thymocyte	879	0.61	0.00	0.65	0.79	0.00	0.89	0.77	0.82	0.92
late pro-B cell	852	0.75	0.80	0.85	0.88	0.00	0.79	0.72	0.88	0.94
kidney collecting duct principal cell	826	0.73	0.89	0.91	0.88	0.00	0.89	0.97	0.96	0.97
basal epithelial cell of tracheobronchial tree	838	0.82	0.74	0.94	0.81	0.00	0.84	0.92	0.87	0.96
mesenchymal cell	781	0.23	0.00	0.41	0.30	0.00	0.44	0.56	0.56	0.55
pancreatic A cell	746	0.65	0.75	0.87	0.88	0.00	0.92	0.95	0.94	0.93
adventitial cell	725	0.66	0.59	0.86	0.54	0.00	0.70	0.84	0.65	0.92
epithelial cell	680	0.43	0.03	0.85	0.70	0.00	0.66	0.58	0.67	0.82
kidney distal convoluted tubule epithelial cell	682	0.82	0.88	0.88	0.74	0.00	0.95	0.97	0.96	0.96
neutrophil	626	0.51	0.50	0.76	0.83	0.00	0.76	0.73	0.67	0.88
pancreatic ductal cell	574	0.93	0.80	0.98	0.95	0.00	0.97	0.98	0.97	0.99
myeloid dendritic cell	570	0.47	0.53	0.87	0.65	0.00	0.86	0.75	0.62	0.80
astrocyte	531	0.91	0.93	0.97	0.95	0.00	0.97	1.00	0.99	0.99
secretory cell	507	0.26	0.35	0.82	0.69	0.00	0.90	0.93	0.88	0.93
myeloid leukocyte	458	0.57	0.33	0.86	0.55	0.00	0.69	0.63	0.71	0.94
plasmatocyte	454	0.81	0.78	0.91	0.82	0.00	0.82	0.89	0.88	0.95
neuron	437	0.61	0.57	0.86	0.81	0.00	0.78	0.95	0.91	0.93
brain pericyte	443	0.53	0.73	0.68	0.87	0.00	0.86	0.97	0.93	0.92
vein endothelial cell	414	0.48	0.77	0.80	0.70	0.00	0.78	0.86	0.80	0.93
pancreatic D cell	424	0.00	0.69	0.90	0.91	0.00	0.93	0.98	0.97	0.98
kidney collecting duct epithelial cell	425	0.39	0.51	0.84	0.86	0.00	0.95	0.91	0.87	0.94
aortic endothelial cell	421	0.16	0.00	0.27	0.43	0.00	0.70	0.38	0.32	0.74
brush cell	371	0.80	0.53	0.93	0.93	0.00	0.73	0.88	0.85	0.91
erythroid progenitor cell, mammalian	371	0.60	0.00	0.89	0.83	0.00	0.35	0.76	0.64	0.93
regular atrial cardiac myocyte	364	0.40	0.42	0.77	0.71	0.00	0.71	0.77	0.73	0.88
kidney cortex artery cell	339	0.78	0.83	0.75	0.50	0.00	0.40	0.75	0.71	0.79
erythrocyte	312	0.69	0.50	0.84	0.90	0.00	0.81	0.81	0.84	0.92
mesangial cell	316	0.00	0.64	0.67	0.74	0.00	0.69	0.84	0.77	0.94
kidney loop of Henle ascending limb epithelial cell	321	0.41	0.60	0.66	0.48	0.00	0.70	0.86	0.86	0.77
cardiac muscle cell	292	0.69	0.63	0.83	0.96	0.00	0.97	0.99	0.96	0.99
mature alpha-beta T cell	293	0.00	0.12	0.40	0.42	0.00	0.70	0.59	0.63	0.79
basophil	294	0.45	0.67	0.85	0.81	0.00	0.61	0.74	0.75	0.85
cardiac valve cell	291	0.73	0.82	0.75	0.87	0.00	0.85	0.93	0.89	0.91
oligodendrocyte precursor cell	274	0.95	0.97	0.97	0.98	0.00	0.98	0.99	1.00	1.00
Schwann cell	248	0.71	0.71	0.86	0.84	0.00	0.82	0.86	0.84	0.82
pulmonary interstitial fibroblast	248	0.94	0.85	0.91	0.89	0.00	0.94	0.91	0.96	0.96
smooth muscle cell of trachea	229	0.00	0.02	0.53	0.46	0.00	0.81	0.71	0.72	0.84
granulocyte monocyte progenitor cell	219	0.00	0.57	0.86	0.82	0.00	0.59	0.81	0.77	0.87
interneuron	218	0.52	0.56	0.81	0.74	0.00	0.78	0.97	0.91	0.91
pancreatic PP cell	201	0.00	0.05	0.72	0.78	0.00	0.85	0.92	0.93	0.93
smooth muscle cell of the pulmonary artery	189	0.00	0.70	0.79	0.42	0.00	0.48	0.87	0.78	0.88
cell of skeletal muscle	170	0.95	0.90	0.76	0.94	0.00	0.94	0.96	0.96	0.97
brush cell of epithelium proper of large intestine	160	0.66	0.70	0.85	0.87	0.00	0.83	0.97	0.94	0.92
Langerhans cell	153	0.91	0.78	0.91	0.77	0.00	0.68	0.90	0.78	0.96
stem cell of epidermis	158	0.00	0.00	0.74	0.79	0.00	0.37	0.60	0.61	0.89
regulatory T cell	155	0.00	0.06	0.20	0.22	0.00	0.44	0.52	0.35	0.77
epithelial cell of thymus	146	0.23	0.03	0.72	0.54	0.00	0.56	0.86	0.58	0.93
enteroendocrine cell	148	0.86	0.76	0.94	0.84	0.00	0.89	0.98	0.95	0.95
kidney capillary endothelial cell	145	0.24	0.50	0.38	0.32	0.00	0.31	0.31	0.32	0.30
neuroepithelial stem cell	130	0.17	0.08	0.87	0.69	0.00	0.54	0.93	0.69	0.82
macrophage dendritic cell progenitor	134	0.00	0.28	0.80	0.84	0.00	0.66	0.79	0.70	0.89
DN3 thymocyte	128	0.00	0.01	0.42	0.81	0.00	0.67	0.80	0.75	0.87
regular ventricular cardiac myocyte	135	0.46	0.04	0.89	0.79	0.00	0.91	0.95	0.99	0.97
endothelial cell of lymphatic vessel	133	0.00	0.43	0.94	0.66	0.00	0.31	0.64	0.48	0.89
ciliated columnar cell of tracheobronchial tree	119	0.00	0.82	0.76	0.93	0.00	0.67	0.96	0.94	0.97
plasmacytoid dendritic cell	112	0.00	0.23	0.87	0.67	0.00	0.44	0.72	0.70	0.90
dendritic cell	97	0.00	0.36	0.76	0.60	0.00	0.65	0.69	0.55	0.81
medium spiny neuron	91	0.00	0.12	0.93	0.87	0.00	0.94	1.00	0.99	0.99
pericyte	88	0.80	0.86	0.81	0.86	0.00	0.83	0.91	0.91	0.94
neural stem cell	85	0.46	0.53	0.88	0.92	0.00	0.79	0.96	0.94	0.96
kidney proximal straight tubule epithelial cell	86	0.00	0.00	0.09	0.00	0.00	0.25	0.60	0.45	0.41
blood cell	76	0.22	0.00	0.32	0.13	0.00	0.24	0.40	0.29	0.39
immature NK T cell	73	0.00	0.02	0.35	0.47	0.00	0.44	0.63	0.52	0.74
cardiac neuron	73	0.00	0.14	0.80	0.70	0.00	0.79	0.84	0.74	0.92
mast cell	66	0.00	0.00	0.62	0.87	0.00	0.73	0.63	0.67	0.85
mucus secreting cell	64	0.00	0.36	0.89	0.83	0.00	0.88	0.98	0.95	0.99
early pro-B cell	63	0.00	0.54	0.76	0.77	0.00	0.81	0.79	0.77	0.93
pancreatic stellate cell	57	0.81	0.69	0.90	0.57	0.00	0.22	0.54	0.85	0.94
ependymal cell	47	0.88	0.49	0.95	0.92	0.00	0.67	1.00	0.96	1.00
Bergmann glial cell	48	0.00	0.54	0.79	0.79	0.00	0.84	1.00	1.00	0.96
neuroendocrine cell	44	0.00	0.00	0.15	0.43	0.00	0.76	0.96	0.81	0.51
fibrocyte	39	0.00	0.00	0.43	0.36	0.00	0.22	0.73	0.57	0.77
hepatic stellate cell	37	0.00	0.10	0.82	0.85	0.00	0.36	0.96	0.86	0.99
club cell	35	0.13	0.41	0.27	0.16	0.00	0.19	0.23	0.22	0.17
respiratory basal cell	33	0.00	0.00	0.95	0.69	0.00	0.39	0.99	0.86	0.91
kidney interstitial fibroblast	14	0.00	0.00	0.78	0.90	0.00	0.36	0.38	0.78	0.93
lymphoid lineage restricted progenitor cell	13	0.96	0.00	0.87	0.78	0.00	0.25	0.09	0.96	0.96
lung neuroendocrine cell	8	0.00	0.00	1.00	0.67	0.00	0.59	0.62	1.00	1.00
kidney cell	3	0.00	0.00	0.00	0.00	0.00	0.32	0.11	0.75	0.50
duct epithelial cell	1	0.00	0.00	0.00	0.00	0.00	0.07	0.25	0.67	0.00

References

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse, The Tabula Muris Consortium, Nicole Almanzar, Jane Antony, Ankit S. Baghel, Isaac Bakerman, Ishita Bansal, Ben A. Barres, Philip A. Beachy, Daniela Berdnik, Biter Bilen, Douglas Brownfield, Corey Cain, Charles K. F. Chan, Michelle B. Chen, Michael F. Clarke, Stephanie D. Conley, Spyros Darmanis, Aaron Demers, Kubilay Demir, Antoine de Morree, Tessa Divita, Haley du Bois, Hamid Ebadi, F. Hernán Espinoza, Matt Fish, Qiang Gan, Benson M. George, Astrid Gillich, Rafael Gòmez-Sjöberg, Foad Green, Geraldine Genetiano, Xueying Gu, Gunsagar S. Gulati, Oliver Hahn, Michael Seamus Haney, Yan Hang, Lincoln Harris, Mu He, Shayan Hosseinzadeh, Albin Huang, Kerwyn Casey Huang, Tal Iram, Taichi Isobe, Feather Ives, Robert C. Jones, Kevin S. Kao, Jim Karkanias, Guruswamy Karnam, Andreas Keller, Aaron M. Kershner, Nathalie Khoury, Seung K. Kim, Bernhard M. Kiss, William Kong, Mark A. Krasnow, Maya E. Kumar, Christin S. Kuo, Jonathan Lam, Davis P. Lee, Song E. Lee, Benoit Lehallier, Olivia Leventhal, Guang Li, Qingyun Li, Ling Liu, Annie Lo, Wan-Jin Lu, Maria F. Lugo-Fagundo, Anoop Manjunath, Andrew P. May, Ashley Maynard, Aaron McGeever, Marina McKay, M. Windy McNerney, Bryan Merrill, Ross J. Metzger, Marco Mignardi, Dullei Min, Ahmad N. Nabhan, Norma F. Neff, Katharine M. Ng, Patricia K. Nguyen, Joseph Noh, Roel Nusse, Róbert Pálovics, Rasika Patkar, Weng Chuan Peng, Lolita Penland, Angela Oliveira Pisco, Katherine Pollard, Robert Puccinelli, Zhen Qi, Stephen R. Quake, Thomas A. Rando, Eric J. Rulifson, Nicholas Schaum, Joe M. Segal, Shaheen S. Sikandar, Rahul Sinha, Rene V. Sit, Justin Sonnenburg, Daniel Staehli, Krzysztof Szade, Michelle Tan, Weilun Tan, Cristina Tato, Krissie Tellez, Laughing Bear Torrez Dulgeroff, Kyle J. Travaglini, Carolina Tropini, Margaret Tsui, Lucas Waldburger, Bruce M. Wang, Linda J. van Weele, Kenneth Weinberg, Irving L. Weissman, Michael N. Wosczyna, Sean M. Wu, Tony Wyss-Coray, Jinyi Xiang, Soso Xue, Kevin A. Yamauchi, Andrew C. Yang, Lakshmi P. Yerra, Justin Youngyunpipatkul, Brian Yu, Fabio Zanini, Macy E. Zardeneta, Alexander Zee, Chunyu Zhao, Fan Zhang, Hui Zhang, Martin Jinye Zhang, Lu Zhou, James Zou; Nature, doi: https://doi.org/10.1038/s41586-020-2496-1