jeffreygwang/pythia_dedupe_mia_0-50000_50010-50025

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As another Berry, the late Chuck Berry, once sang, “C’est la vie, say the old folks, it goes to show you never can tell.” PG-13? The sometimes earthy nature of coach-to-player communication led to a playful question for former UK players arriving for the preview screening of ESPN’s 30 for 30 film on John Calipari: What rating should be given the film if it accurately portrays how the UK coach communicates? “An honest portrayal would give it a PG-13,” Mark Krebs said with a smile. Kentucky coach John Calipari spoke after the preview screening of his new ESPN documentary, "One and Not Done." The film will air on April 13 at 9 p.m. on ESPN. Caitlyn [email protected] One and not done One viewing of the ESPN 30 for 30 film on UK Coach John Calipari wasn’t enough for UK fan Barry Britton. A Lexington native and UK graduate in the class of 1968, Britton wrote an email asking if and how the film could be purchased. Britten said he wanted copies for two friends who forgot to tape the show. He also wants to add it to his library of UK tapes and books. ESPN said that DVDs will be available at Amazon.com beginning on May 30. A digital version can be bought on iTunes. Heshimu Evans? Heshimu Evans, who played for Kentucky in 1996-97, 1997-98 and 1998-99, attended the ESPN 30 for 30 preview. Although Rick Pitino and Tubby Smith were his UK coaches, Evans said he had a connection to John Calipari. Son also rises Shareef O’Neal, a four-star prospect and the son of Shaquille O’Neal, committed to Arizona last week. Listed as 6-9 and 204 pounds, the younger O’Neal isn’t nearly as physically imposing as his father. Shareef O’Neal was not the only son of a former NBA player on his California-based AAU team. One of his teammates was Bol Bol, the son of Manute Bol. The younger Bol is ranked No. 16 by 247 Sports and has a scholarship offer from Arizona. From the just-wondering file: Has Bol Bol spent any time in Walla Walla? Ex-Cat’s camp Dale Brown (the ex-UK player, not the former LSU coach) plans to stage a basketball camp in Lexington on June 9-10. The camp is for boys and girls ages 6 through 17. Brown, a regular on the UK team that lost the Christian Laettner game and a starter on the 1993 Final Four team, will hold the camp at Calvary Baptist Church. Entry fee is $70. Registration is at Calvary Baptist Church or by calling 404-998-2412 or at [email protected]. Belated birthday wishes To Isaiah Briscoe. He turned 21 on April 13. … To Derrick Jasper. He turned 29 on April 13. … To Mark Soderberg. He turned 67 on April 14. … To Dwane Casey. He turned 60 on April 17. … To Michael Bradley. He turned 38 on April 18. … To Derrick Millar. He turned 49 on April 18. … To Nate Knight. He turned 39 on April 18. … To former UK baseball player Doug Flynn. He turned 66 on April 18. … To Scott Padgett. He turned 41 on April 19. … To Ashley Judd. She turned 49 on April 19. Happy birthday To Ryan Harrow. He turned 26 on Saturday. … To Fred Cowan. He turns 59 on Sunday (today). … To Father Ed Bradley. He turns 74 on Monday. … To Dillon Pulliam. He turns 22 on Tuesday. … To former UK assistant David Hobbs. He turns 68 on Tuesday. … To Bob Tallent. He turns 71 on Wednesday.Customers don’t just buy a product — they switch from something else. And customers don’t just leave a product — they switch to something else. The first workshop sold out in just 5 days, so if you‘d like to attend, register now. It’s in these switching moments that the deepest customer insights can be found. On the 2nd of November, a select group of 24 people will attend a unique, hands-on, full-day workshop to learn about “The Switch”. Most businesses don’t know the real reasons why people switch to — or from — their products. We’ll teach you how to find out. The workshop will be at the 37signals office in Chicago. The cost to attend is $1000. The workshop will be led by 37signals and The Rewired Group. You’ll participate in live customer interviews. You’ll learn new techniques for unearthing the deep insights that most companies never bother to dig up. You’ll understand why people switch from one product to another and how you can increase the odds that the switch goes your way. And you’ll be able to put everything you learned to immediate use. There’s only one simple requirement: You’ll be asked to bring something with you. It won’t be a big deal. Details will be provided one week before the workshop. Spots are limited. Only 24 people will be able to attend and participate. Want to be one of the 24? Register now. We will see you on November 2. George M. This is a very very interesting idea. So many SASS catagories have been multiple competing webapps (accounting or project managment for instance)—switching for MVP feels like a worthwhile strategy. Would like hear more on your thoughts guys! JF on 15 Oct 12 George: Because this isn’t what The Starter League currently teaches. The Starter League teaches Rails, HTML/CSS, and User Experience Design. Further, The Starter League classes are taught on a quarterly system, while this particular workshop is one day. Entirely different topics and teaching methods. George M. on 15 Oct 12 @JF “Further, The Starter League classes are taught on a quarterly system, while this particular workshop is one day.” That statement just plain sounds like your unwillingness to be flexible, because it doesn’t fix the “typical” schedule already in place. That’s really sad to hear, given how much you preach about being flexible and providing a great customer acquisition experience (e.g. Nuts.com great experience, and many-many more..) This doesn’t provide any of that. Maybe that should be lesson #1 of this class. Just a thought. Alex on 15 Oct 12 Would these be relevant for offline/local business (e.g. real estate) or is this only relevant for online? JF on 15 Oct 12 Alex: Highly relevant for offline/local. One of the teachers used to sell houses, in fact. That’s where he learned many of these lessons. Phil C. on 15 Oct 12 I actually went to the last seminar, and would gladly bring my entire marketing and product teams to do it again if I could. What you’ll learn: a simple way of interviewing your customers and clients that will yield insight into what really matters to them. (Importantly, you’ll learn what actually matters to them, not what they say matters, which are two different things entirely. This style of interviewing clients focuses on their actual behaviors and decisions, not on their after-the-fact rationalizations for those decisions or on what they would do in hypothetical situations, as focus groups - and even feature requests - often do.) With that insight, you can then engineer specific solutions to the real, felt problems your customers are looking to solve—and willing to spend their hard earned money to address. Rewired is doing this with some of the largest brands in the world already. Tech companies have some ground to make up in this department. But to Alex: it would be equally valuable for offline businesses. In fact, one of the best case studies we learned about was a hilariously counter-intuitive story of a real estate developer using this technique to increase its sales 20% while the rest of the market plummeted 60%. And making its clients happier in the process. I’d be shocked if they didn’t share that exact case study again, because it’s a classic. In short, this is like usability testing for marketers. Or marketing for engineers, as one person put it. If you like testing, you’ll love this. If you like winging it with your marketing or taking a more intuitive or purely creative approach, you won’t. Roger W. on 16 Oct 12 Jason . . . would this be good for someone offering a service like software training? JF on 16 Oct 12 Roger: Definitely. This is for anyone who wants to understand their customers’ motivations at a much deeper level. If you sell anything, these interview techniques will be very useful. DB on 16 Oct 12 They irony in how many people are confused in what this workshop is for and why they should pay for it … given the topic of the class
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3718, 187, 50273, 395, 323, 2717, 15, 496, 253, 1083, 273, 247, 33437, 2419, 13, 627, 310, 187, 50273, 7483, 271, 6431, 273, 5113, 273, 6021, 15, 380, 1436, 281, 5207, 352, 187, 50273, 261, 33437, 4245, 598, 247, 5110, 273, 521, 13, 285, 253 ]	is what we find: Top Spending Districts: average $17,221 per student with scores of 10% readiness in reading and 3% in math. Lowest Spending Districts: average $9,926 per student with scores of 27% in readiness in reading and 22% in math. Clearly there are lots of other factors related to performance other than how much is spent, but the pattern of false choices is clear. Instead of doing real work to figure this out, it’s a lot easier to revert to false choices. Option A – increase education spending or Option B spend less on education. The outcome, we get spending that is unrelated to outcomes. State Government Spending, False Choice #3: There is probably no policy issue that is a better example of false choices than overall government spending. Option A: traditional liberals/Democrats say we need more government spending because we have so many problems in the state that need fixing. Option B: traditional conservatives/Republicans say we need less government spending so people can keep more of their tax money and spend it on what they want, not what the government wants. The outcome is across the board spending cuts or increases. The real issue should be what is effective, what provides the most return on investment or what issues are most pressing. Instead, either side wants to raise or cut spending and so they take the simplistic way out – they split the difference by raising or lowering spending. This principle of split the difference applies not only to overall state spending but it filters down to the political horse trading of spending on individual agencies and programs. This same false choices problem extends to a myriad of other issues: more or less regulation, shorter or longer sentences for criminals, corporate or individual taxes … it goes on and on. It does not have to be this way. What’s needed is a basic common-sense approach not distorted by ideology or special interest lobbyists. We need to ask: does it work, is it effective, is it really important, will it save money in the long run, what is the cost if we do nothing? There is no Democratic or Republican way to fill a pot hole. We need to insist that more is not better, less is not better – but better is better. We will only find solutions to our problem when we realize it’s really about change vs. status quo, about openness vs. closed government, about reformers vs. political insiders, about the people’s interest vs. the special interest, about new innovative leaders vs. corrupt career politicians. We are a great state and we can do great things – with big change and real reform. Phil Noble has a technology firm in Charleston, is founder of World Class Scholars and writes a weekly column for the S.C. Press Association. Reach him at This email address is being protected from spambots. You need JavaScript enabled to view it. and get his columns at www.PhilNoble.com. Produced by Frank van Drogen, Carol Brown, Gwen Adams, Elizabeth Oscanyan, and the Online Distributed Proofreading Team at http://www.pgdp.net. Transcriber's Note: A monospaced font will display the tables in this book better than a variable-spaced font. PRINCIPLES OF POLITICAL ECONOMY BY WILLIAM ROSCHER, PROFESSOR OF POLITICAL ECONOMY AT THE UNIVERSITY OF LEIPZIG, CORRESPONDING MEMBER OF THE INSTITUTE OF FRANCE, PRIVY COUNSELLOR TO HIS MAJESTY, THE KING OF SAXONY. FROM THE THIRTEENTH (1877) GERMAN EDITION. WITH ADDITIONAL CHAPTERS, FURNISHED BY THE AUTHOR, FOR THIS FIRST ENGLISH AND AMERICAN EDITION, ON PAPER MONEY, INTERNATIONAL TRADE, AND THE PROTECTIVE SYSTEM; AND A PRELIMINARY ESSAY ON THE HISTORICAL METHOD IN POLITICAL ECONOMY (From the French) BY L. WOLOWSKI, THE WHOLE TRANSLATED BY JOHN J. LALOR, A. M. VOL. II. [Illustration: Printer's Logo] NEW YORK: HENRY HOLT & CO. 1878. Entered according to Act of Congress, in the year eighteen hundred and seventy-eight, BY CALLAGHAN & CO., In the office of the Librarian of Congress, at Washington, D. C. DAVID ATWOOD, STEREOTYPER AND PRINTER, MADISON, WIS. TO WILLIAM H. GAYLORD, ESQ., _COUNSELOR AT LAW_, OF CLEVELAND, OHIO, TO WHOSE BROTHERLY CARE IT IS LARGELY DUE THAT I LIVED TO TRANSLATE THEM, THESE VOLUMES ARE AFFECTIONATELY INSCRIBED. BOOK III. DISTRIBUTION OF GOODS. CHAPTER 1. INCOME IN GENERAL. SECTION CXLIV. RECEIPTS.--INCOME.--PRODUCE. The idea covered by the word receipts (_Einnahme_) embraces all the new additions successively made to one's resources within a given period of time.[144-1] Income, on the other hand, embraces only such receipts as are the results of economic activity. (See Secs. 2, 11.) Produce (_Ertrag_, _produit_) is income, but not from the point of view of the person or _subject_ engaged in a business of any kind, but from that of the business itself, or of the _object_ with which the business is concerned, and on which it, so to speak, acts. Income is made up of products, the results of labor and of the employment and use of resources. These products, the producer may either consume himself or exchange against other products, to satisfy a more urgent want.[144-2] Hence, spite of the frequency with which we hear such expressions as these: "the laborer eats the bread of his employer;" "the capitalist lives by the sweat of the brow of labor;" or, again, a manufacturer or business man "lives from the income of his customers,"[144-3] they are entirely unwarranted. No man who manages his own affairs well, or those of a household, lives on the capital or income of another man; but every one lives on his own income, by the things he has himself produced; although with every further development of the division of labor, it becomes rarer that any one puts the finishing stroke to his own products, and can satisfy himself by their immediate consumption alone. Hence we should call nothing diverted or derived income except that which has been gratuitously obtained from another.[144-4] [Footnote 144-1: Including of course, gifts, inheritances, lottery prizes, etc.] [Footnote 144-2: Thus the original income of the peasant consists in his corn, of the miller in his flour, of the baker in his bread, of the shoemaker in his shoes. The money which circulates among all these and the purchaser, is only the means of exchanging that part of their products which they cannot themselves use, for other goods. Money, on the other hand, was the original income of the producers of the gold or silver it contains. Compare _Mirabeau_, Philosophie rurale, 1763, ch. 3. _Adam Smith_, II, ch. 2. But especially, see _J. B. Say_, Traite II, ch. 1, 5; and _Sismondi_, N. P., I, 90, 376, in which it is correctly said, that the quality which constitutes anything capital or income does not inhere in the thing itself, but depends on the person. Compare, however, I, 148; _Hermann_, Staatsw. Untersuch. 297 ff., 33 seq.] [Footnote 144-3: A fundamental thought in _St. Chamans_, Du Systeme d'Impot, 1820. Nouvel Essai sur la Richesse des Nations, 1824.] [Footnote 144-4: Thus, for instance, the support given by the head of a family to the members thereof; also gifts, alms, thefts. Even _A. L. Schloezer_, St. A., II, 487, will allow that no one "eats the bread of another," but the person who has received it from the latter by way of favor and for nothing. In the case of a rented house, there is only an exchange of objects of income. The person to whom it is rented gives up a portion of his, and the
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14, 84, 7551, 253, 12020, 17578, 14, 5993, 46, 1341, 281, 4044, 247, 894, 3072, 342, 247, 2406 ]	inetochore-chromatin' or '[K]{.ul}-chromatin' (Fig. [4e](#Fig4){ref-type="fig"}). The K-chromatin localisation finding is consistent with our notion that centromeric chromatin is probably targeted by the UFB-binding complex after PLK1 inhibition. If the increased formation of RPA foci at K-chromatin reflects aberrant DNA unwinding, this may weaken centromere rigidity to counteract spindle pulling forces. Notably, we observed detachments of KT complex in a small population of centromeres (\<4%) in metaphase(-like) cells prior to collapse. Intriguingly, some of the KTs remained connected by a short thread, as labelled by PICH or RPA staining (Fig. [5a, b](#Fig5){ref-type="fig"}; arrows). Centromere staining was sometimes evident along the short thread (Fig. [5a](#Fig5){ref-type="fig"}; arrows), implying a protrusion of centromeric DNA. We postulated that this might be the early sign of centromere disintegration. Further analysis of the centromere-KT integrity revealed that there was a large percentage of centromeres losing one of the two sister KTs after metaphase collapse (Fig. [5b--d](#Fig5){ref-type="fig"}). The side of the centromere where a KT was missing was concomitant with the formation of DNA thread linkages (Fig. [5c](#Fig5){ref-type="fig"}; connecting arrows). Therefore, there are apparent alterations on the centromere-KT configuration prior to and during centromere disintegration.Fig. 5Loss of kinetochore attachment at centromeres after dislocation. a Representative images showing the kinetochore complex detaches from the core centromere, whilst remaining connected by PICH- or RPA-coated DNA threads (arrows) in BI2536-treated metaphase-like RPE1 cells. Inner and outer kinetochores were labelled by CENPA and NUF2, respectively. b Examples showing the majority of centromeres retain two kinetochores in pre-collapsed mitotic populations (prometaphase and metaphase-like cells) after BI2536 treatment. c Representative image showing the metaphase-collapse cells losing kinetochore complex at one side of the centromere. Note: the side without the kinetochore is concomitant with the formation of PICH-associated DNA linkages (arrows). Enlarged images (1 and 2) highlight the loss of CENPA signal at regions of where PICH-decorated DNA linkages form (arrows). d Quantification of the numbers of CENPA- and NUF2-labelled kinetochores at centromeres in prometaphase, metaphase-like and collapse stages after BI2536 treatment (n = 3 independent experiments analysing a total of 3020 CENPA-labelled centromeres and 3625 NUF2-labelled centromeres; mean ± S.D. is shown). Note: all RPE1 cells analysed were pre-synchronised at G1/S by single thymidine block. Drugs were added at 6 h post-release. After 2 h treatment, cells were subject to immunofluorescence staining. Scale bars = 5 μm BLM helicase activity mediates centromere disintegration {#Sec10} -------------------------------------------------------- Next, we examined whether centromere disintegration is mediated by BLM and PICH. We knocked down BLM by RNAi before BI2536 treatment (Fig. [6a](#Fig6){ref-type="fig"}). Silencing BLM for longer than 48 h in RPE1 cells reduced the efficiency of thymidine release, therefore we treated cells with siBLM oligos for only 24 h prior to G1/S release (Supplementary Fig. [12a](#MOESM1){ref-type="media"}). Despite partial depletion (Supplementary Fig. [12b--d](#MOESM1){ref-type="media"}), we found that first, BLM knockdown significantly reduced the formation of RPA foci at K-chromatin induced by BI2536 (Fig. [6b](#Fig6){ref-type="fig"}); second, it also diminished both centromere DNA thread formation and centromere dislocation (Supplementary Fig. [12e, f](#MOESM1){ref-type="media"}). BLM depletion did not impair PICH centromeric localisation (Supplementary Fig. [12g](#MOESM1){ref-type="media"}), suggesting that, without BLM, PICH alone is not sufficient to drive centromere disintegration. To confirm the specificity of BLM knockdown, we performed our analyses on HAP1 cells in which the endogenous BLM was knocked out by CRISPR genome editing^[@CR38]^ (Supplementary Fig. [1](#MOESM1){ref-type="media"}3[a, b](#MOESM1){ref-type="media"}). Consistently, BLM knockout abolished centromere DNA thread formation and centromere dislocations (Fig. [6c](#Fig6){ref-type="fig"}, d). Though, occasionally, chromatid breaks were observed in ΔBLM HAP1 cells, the breakpoint was not at the centromere (Fig. [6d](#Fig6){ref-type="fig"}, arrow). Therefore, in addition to the bipolar spindle pulling forces, BLM is a key driver of centromere disintegration after the loss of PLK1 activity.Fig. 6BLM helicase activity triggers centromere disintegration. a Western blot showing BLM depletion after RNAi treatment in RPE1 cells. Ku80 is used as a loading control. b BLM depletion reduced centromeric RPA foci formation induced by BI2536 in pre-collapsed metaphase(-like) cells. Representative images showing the loss of RPA, but not PICH foci, at centromeres in siBLM cells. Right: quantification of centromeric RPA foci in metaphase(-like) cells (n = 3 independent experiments analysing 60 cells per condition; mean ± S.D. is shown). c Representative images and quantification of DNA thread formation in wild-type (HAP1) cells, BLM knockout cells (ΔBLM), and ΔBLM HAP1 cells complemented with a wild-type GFP-BLM (WT) and a BLM-helicase mutant (Q672R) protein under BI2536 treatment (n = 3 independent experiments analysing a total of 291, 218, 204 and 184 cells in HAP1, ΔBLM, WT and Q672R cell lines; mean ± S.D. is shown). d Representative chromosome images of 'centromere dislocations' (yellow asterisks) in the indicated HAP1 cells shown in (c). Note: occasional arm breaks (arrow) were observed in ΔBLM cells. Quantification of centromere dislocation is shown below (n = 3 independent experiments analysing a total of 60, 60, 51 and 51 spreads in HAP1, ΔBLM, WT and Q672R cell lines; means of each experiment are shown). e Centromeric RPA foci formation in ΔBLM HAP1 cells expressing wild-type GFP-BLM (WT) and a BLM helicase-dead mutant (GFP-Q672R) following BI2536 treatment. Representative images showing the lack of RPA foci at centromeres in the GFP-Q672R cells. Right: bar graphs showing the average fluorescence intensities of centromere GFP and RPA foci, respectively, in GFP-BLM and GFP-Q672R cells (mean + S.E.M. is shown). A scatter plot of RPA foci intensity by GFP foci intensity at centromeres (total numbers of centromere foci analysed: GFP-BLM, n = 582; and GFP-Q672, n = 481). All RPE1 and HAP1 cells, including their derivatives, were pre-synchronised at G1/S by single thymidine block. Drugs were added at 6 h post-release. After 2 h treatment, cells were subject to immunofluorescence staining. RNAi treatment of RPE1 cells was performed for 23 h before G1/S release. Scale bars = 5 μm Centromere disintegration might be initiated through unlawful DNA unwinding by BLM. Thus, we determined if BLM's helicase activity is required. We generated polyclonal cell lines from the ΔBLM HAP1 cells, which stably express either a GFP-tagged WT or a helicase-dead (Q672R) BLM protein. The expression of the GFP-Q672R protein was similar to the endogenous BLM level in HAP1 cells; whereas, the GFP-WT was over-expressed (Supplementary Fig. [13b](#MOESM1){ref-type="media"}). In agreement with our notion, the helicase-dead (Q672R) BLM failed to induce centromere DNA threads and dislocations caused by BI2536 treatments (Fig. [6c, d](#Fig6){ref-type="fig"}). However, as the expression level of the GFP-Q672R mutant was lower than the WT control; to perform a better comparison, we re-sorted the WT GFP-BLM cells to obtain a cell population with a lower
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3680, 1010, 2251, 186, 20, 187, 19882, 746, 186, 1099, 43784, 1717, 186, 21553, 2537, 27571, 186, 21, 187, 19882, 746, 186, 21553, 1438, 34307, 186, 1099, 3141, 1093, 805, 186, 19, 187, 19882, 746, 186, 1731, 2251, 2055, 3832, 186, 1731, 38518, 13210, 186, 21, 187, 19882, 746, 186, 1630, 1717, 740, 1449, 186, 22818, 11838, 3156, 186, 20, 187, 19882, 746, 186, 1619, 19443, 31254, 186, 1619, 22981, 18950, 186, 18, 187, 19882, 746, 186, 1619, 1671, 938, 2597, 186, 1619, 1671, 1731, 3439, 186 ]	IsNonExpandable="False"> <toolkit:ExpanderView.HeaderTemplate> <DataTemplate> <TextBlock Text="{Binding LocationName}" FontFamily="{StaticResource PhoneFontFamilySemiBold}" LineHeight="{StaticResource LongListSelectorGroupHeaderFontSize}" /> </DataTemplate> </toolkit:ExpanderView.HeaderTemplate> <toolkit:ExpanderView.ExpanderTemplate> <DataTemplate> <TextBlock Text="test" /> </DataTemplate> </toolkit:ExpanderView.ExpanderTemplate> <toolkit:ExpanderView.ItemTemplate> <DataTemplate> <TextBlock Text="{Binding Information}" /> </DataTemplate> </toolkit:ExpanderView.ItemTemplate> </toolkit:ExpanderView> </DataTemplate> </ListBox.ItemTemplate> </ListBox> The ContactViewModel-Class: public class ContactDeViewModel : INotifyPropertyChanged { private string _locationName; public string LocationName { get { return _locationName; } set { if (value != _locationName) { _locationName = value; NotifyPropertyChanged("LocationName"); } } } private List<string> _information; public List<string> Information { get { return _information; } set { if (value != _information) { _information = value; NotifyPropertyChanged("Information"); } } } } And this is where I fill the ContactViewModel: this.ContactDe.Add(new ContactDeViewModel() { LocationName = "Stuttgart", Information = new List<string> { "some text" } } ); this.ContactDe.Add(new ContactDeViewModel() { LocationName = "Böblingen", Information = new List<string> { "more text" } } ); I made a SampleViewModel-File where I have: <vm:MainViewModel.ContactDe> <vm:ContactDeViewModel LocationName="Location 1" /> <vm:ContactDeViewModel LocationName="Location 2" /> </vm:MainViewModel.ContactDe> In the preview-window it shows me 2 ExpanderViews with Location 1 and 2. But the same code doesn't work with the emulator or a real device. I don't really understand which Binding-Acces does what. It would already help me a lot if I could see a full example. I googled many tutorials but most only show 1 side, like a xaml without seing how the data is stored. edit: Now I edited the viewModel, so it's not a List<string> but a List<Info> with Info only containing string Text. So now I can say ItemsSource="{Binding Text}" which should be only 1 string at a time, right? A: As stated in comment to @dellywheel's answer, that you set DataContext this way : d:DataContext="{d:DesignData SampleData/MainViewModelSampleData.xaml}" that set DataContext for use in design-time only, hence it doesn't work in run-time. To set DataContext with similar approach for use in run-time, you can try this way : <ListBox ItemsSource="{Binding ContactDe}"> <ListBox.DataContext> <vm:MainViewModel/> </ListBox.DataContext> ........ ........ </ListBox> or this way to set DataContext in page level : <phone:PhoneApplicationPage> <phone:PhoneApplicationPage.DataContext> <vm:MainViewModel/> </phone:PhoneApplicationPage.DataContext> ........ ........ </phone:PhoneApplicationPage> Another suggestion, prefer ObservableCollection rather than List for use along with data binding. ObservableCollection automatically notify view to refresh whenever item added to or removed from collection. Prevalence and risk factors of osteoporosis in patients with ankylosing spondylitis: a 5-year follow-up study of 504 cases. The objective of this study was to assess the prevalence and risk factors of osteoporosis (OP) in patients with ankylosing spondylitis (AS). Demographic and clinical data of 504 AS patients were collected. Bone mineral density (BMD) measurements of the lumbar spine, proximal femur and forearm were performed by dual-energy x-ray absorptiometry at baseline and follow-up. 106 cases of sex- and age-matched healthy volunteers were enrolled as normal controls. In contrast to normal controls, AS patients displayed a higher prevalence of both OP (9.7% vs. 0%) and osteopenia (57.5% vs. 34.9%). The prevalence of OP was significantly higher and the BMD were significantly lower in patients with elevated erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) than patients with normal ESR and CRP. Juvenile onset, morning stiffness lasting over 0.5 hours and elevated ESR levels were risk factors for bone loss at the lumbar spine; Male gender, older age, hip involvement and lack of regular treatment were risk factors for bone loss at the femur. 173 cases were followed up for 1 to 5 years, BMD changes per year at the lumbar spine, femur and forearm were 4.8%, 2.7%, and 2.6% respectively. There was no significant difference in annual BMD change between patients treated with or without low dose glucocorticoids (GCs). Hip involvement and persistent elevated ESR levels, but not GCs treatment, were associated with decreased BMD at both the lumbar spine and the femur during follow-up in longitudinal regression analysis. High disease activity and hip involvement are risk factors of bone loss in patients with AS. Low-dose GCs treatment in AS does not increase the risk of OP.chr17 1 100 0 chr19 -50 1000 0 chr19 3372152 4121576 1 chr19 4214363 4477570 4 chr19 4709030 4709411 2 chr19 4711183 5069515 3 chr19 5081241 5449223 2 chr19 5535477 5536121 1 chr19 5559281 5561813 4 chr19 5592723 5742913 2 chr19 5861815 5862460 1 chr19 6021539 6022179 2 chr19 6248108 6249473 3 chr19 6427431 6429057 2 chr19 6496595 6497258 1 chr19 6497316 6499591 3 chr19 6530969 6532621 4 chr19 6904460 6905659 2 chr19 6913637 6915725 1 chr19 7000038 7009252 3 chr19 7238983 7241901 4 chr19 7496474 7497832 1 chr19 9063034 10532111 2 chr19 10955709 10956457 1 chr19 11467143 11467813 3 chr19 11874452 11875165 2 chr19 12575094 12576646 4 chr19 12670174 12671551 2 chr19 15868427 15869091 3 chr19 16509957 16511637 1 chr19 16521332 16522096 2 chr19 16841217 16842101 1 chr19 16944579 17912386 4 chr19 19184357 20628964 3 chr19 21546489 21547340 2 chr19 23347635 23464586 1 chr19 23832852 23834404 3 chr19 23966885 23968713 4 chr19 24104526 24105945 2 chr19 24629837 24675579 1 chr19 24935646 24936745 2 chr19 24971366 24973039 3 chr19 24973379 24975947 4 chr19 25073511 25074595 2 chr19 25222902 25223595 1 chr19 25579641 25581567 3 chr19 25678929 25749281 4 chr19 25780994 25781812 2 chr19 26678861 26683116 4 chr19 27291040 27614541 3 chr19 28217754 28218306 1 chr19 28352087 28352654
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3914, 16983, 558, 535, 50270, 338, 4816, 6275, 25016, 11013, 3221, 2785, 370, 6275, 25016, 10, 551, 187, 50266, 338, 313, 33915, 3914, 27641, 5013, 292, 356, 47916, 551, 187, 50262, 5, 6275, 25016, 426, 3781, 2073, 2025, 356, 8, 3001, 370, 27641, 5013, 292, 356, 34419, 187, 50266, 94, 535, 50266, 338, 313, 33915, 3914, 27641, 5013, 6275, 14, 25016, 47916, 551, 187, 50262, 338, 313, 261, 64, 3728, 3914, 6275, 25016, 1228, 551, 187, 50258, 5, 6275 ]	); return PEAR::raiseError("Could not write $file."); } } else { fclose($cachefile_fp); $link = function_exists('readlink') ? readlink($file) : $file; return PEAR::raiseError('SECURITY ERROR: Will not write to ' . $file . ' as it is symlinked to ' . $link . ' - Possible symlink attack'); } } fclose($cachefile_fp); return true; } /** * Efficiently Download a file through HTTP. Returns downloaded file as a string in-memory * This is best used for small files * * If an HTTP proxy has been configured (http_proxy PEAR_Config * setting), the proxy will be used. * * @param string $url the URL to download * @param string $save_dir directory to save file in * @param false\|string\|array $lastmodified header values to check against for caching * use false to return the header values from this download * @param false\|array $accept Accept headers to send * @return string\|array Returns the contents of the downloaded file or a PEAR * error on failure. If the error is caused by * socket-related errors, the error object will * have the fsockopen error code available through * getCode(). If caching is requested, then return the header * values. * * @access public / function downloadHttp($url, $lastmodified = null, $accept = false, $channel = false) { static $redirect = 0; // always reset , so we are clean case of error $wasredirect = $redirect; $redirect = 0; $info = parse_url($url); if (!isset($info['scheme']) \|\| !in_array($info['scheme'], array('http', 'https'))) { return PEAR::raiseError('Cannot download non-http URL "' . $url . '"'); } if (!isset($info['host'])) { return PEAR::raiseError('Cannot download from non-URL "' . $url . '"'); } $host = isset($info['host']) ? $info['host'] : null; $port = isset($info['port']) ? $info['port'] : null; $path = isset($info['path']) ? $info['path'] : null; $schema = (isset($info['scheme']) && $info['scheme'] == 'https') ? 'https' : 'http'; $proxy_host = $proxy_port = $proxy_user = $proxy_pass = ''; if ($this->config->get('http_proxy')&& $proxy = parse_url($this->config->get('http_proxy')) ) { $proxy_host = isset($proxy['host']) ? $proxy['host'] : null; if ($schema === 'https') { $proxy_host = 'ssl://' . $proxy_host; } $proxy_port = isset($proxy['port']) ? $proxy['port'] : 8080; $proxy_user = isset($proxy['user']) ? urldecode($proxy['user']) : null; $proxy_pass = isset($proxy['pass']) ? urldecode($proxy['pass']) : null; $proxy_schema = (isset($proxy['scheme']) && $proxy['scheme'] == 'https') ? 'https' : 'http'; } if (empty($port)) { $port = (isset($info['scheme']) && $info['scheme'] == 'https') ? 443 : 80; } if (isset($proxy['host'])) { $request = "GET $url HTTP/1.1\r\n"; } else { $request = "GET $path HTTP/1.1\r\n"; } $request .= "Host: $host\r\n"; $ifmodifiedsince = ''; if (is_array($lastmodified)) { if (isset($lastmodified['Last-Modified'])) { $ifmodifiedsince = 'If-Modified-Since: ' . $lastmodified['Last-Modified'] . "\r\n"; } if (isset($lastmodified['ETag'])) { $ifmodifiedsince .= "If-None-Match: $lastmodified[ETag]\r\n"; } } else { $ifmodifiedsince = ($lastmodified ? "If-Modified-Since: $lastmodified\r\n" : ''); } $request .= $ifmodifiedsince . "User-Agent: PEAR/1.9.1/PHP/" . PHP_VERSION . "\r\n"; $username = $this->config->get('username', null, $channel); $password = $this->config->get('password', null, $channel); if ($username && $password) { $tmp = base64_encode("$username:$password"); $request .= "Authorization: Basic $tmp\r\n"; } if ($proxy_host != '' && $proxy_user != '') { $request .= 'Proxy-Authorization: Basic ' . base64_encode($proxy_user . ':' . $proxy_pass) . "\r\n"; } if ($accept) { $request .= 'Accept: ' . implode(', ', $accept) . "\r\n"; } $request .= "Accept-Encoding:\r\n"; $request .= "Connection: close\r\n"; $request .= "\r\n"; if ($proxy_host != '') { $fp = @fsockopen($proxy_host, $proxy_port, $errno, $errstr, 15); if (!$fp) { return PEAR::raiseError("Connection to `$proxy_host:$proxy_port' failed: $errstr", -9276); } } else { if ($schema === 'https') { $host = 'ssl://' . $host; } $fp = @fsockopen($host, $port, $errno, $errstr); if (!$fp) { return PEAR::raiseError("Connection to `$host:$port' failed: $errstr", $errno); } } fwrite($fp, $request); $headers = array(); $reply = 0; while ($line = trim(fgets($fp, 1024))) { if (preg_match('/^([^:]+):\s+(.)\s*\\z/', $line, $matches)) { $headers[strtolower($matches[1])] = trim($matches[2]); } elseif (preg_match('\|^HTTP/1.[01] ([0-9]{3}) \|', $line, $matches)) { $reply = (int)$matches[1]; if ($reply == 304 && ($lastmodified \|\| ($lastmodified === false))) { return false; } if (!in_array($reply, array(200, 301, 302, 303, 305, 307))) { return PEAR::raiseError("File $schema://$host:$port$path not valid (received: $line)"); } } } if ($reply != 200) { if (!isset($headers['location'])) { return PEAR::raiseError("File $schema://$host:$port$path not valid (redirected but no location)"); } if ($wasredirect > 4) { return PEAR::raiseError("File $schema://$host:$port$path not valid (redirection looped more than 5 times)"); } $redirect = $wasredirect + 1; return $this->downloadHttp($headers['location'], $lastmodified, $accept, $channel); } $length = isset($headers['content-length']) ? $headers['content-length'] : -1; $data = ''; while ($chunk = @fread($fp, 8192)) { $data .= $chunk; } fclose($fp); if ($lastmodified === false \|\| $lastmodified) { if (isset($headers['etag'])) { $lastmodified = array('ETag' => $headers['etag']); } if (isset($headers['last-modified'])) { if (is_array($lastmodified)) { $last
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281, 1908, 32, 187, 187, 7673, 273, 619, 1679 ]	media literates, to stop using Facebook like the 500 million other people out there and find some blocked political blog or something? 5. Who exactly is arguing that satisfaction with the CCP means they “have to stay ignorant about things concerning China”? Why do you even think that? What, caring about Liu and Charter 08 is the key indicator of how much someone knows about things concerning China?” Are you serious? 6. And trotting out the “single source of information” line? Are you serious? How do you know that? You don’t, you assume it. It fits with the brainwashed narrative that is so convenient to slap onto them, doesn’t it? Sure, some, even many, could be guilty of it, but do you really know? There is less know and more eagerness to believe because it reaffirms you of your identity as being different, more “literate”, even “better” than them. Look, there are reasons behind them not sharing your position on and enthusiasm for something you care about. For some, it may very well be the reasons you’re ascribing to them, but how is that conclusion going to help you? How is it going to “help” them? That was a sorry excuse of a reply Kai Pan, really. You replied at lenght without actually saying one thing, and you obviously did not properly read my post either. 1) It’s an English speaking Western University in China, not a Chinese university. They can speak openly about subjects and challenge official viewpoints, neither the students or professors have to self-censor themselves (too much). Point in case: there are lectures about media censorship in China.. 2) being media literate and knowledgeable about world affairs is part of their studies, so there’s no excuse for not knowing such things. 3) Having an opinion (that of the CCP) without secondary sources of information is inexcusable for students of International Business Communications taking courses in Political Economy. That is the whole point, they have an opinion which exactly mirrors the official viewpoint without actually bothering to inform themselves or even read the primary sources (Chapter 08). I clearly stated that having this opinion is no problem nor is it objectionable, what is bad is that they don’t know what they’re talking about. The rest of your reply is just silly so I won’t go into that, judging from the votes some others would probably agree. Simon, I said plenty but I can’t force you to acknowledge them. Oh well. 1) You said “best English speaking University in China”, not “Western University in China”. I don’t think my understanding was unreasonable. Even so, they’re still under the jurisdiction of the Chinese government. You’d be naive to think otherwise. My point still stands. 2) Of course there is. It’s the same excuse as everywhere else, for university students everywhere. All of them have curriculum that advocates becoming media literate and knowledgeable about world affairs but how many are and about all world affairs? You said you attend that university as well, right? I’m certain I can find a topic for which I can apply the same criticism to you. If you haven’t understood yet, my point is that you’re jumping to unreasonable characterizations. 3) How do you know they don’t have secondary sources of information? You’re assuming so based upon your prejudice of their disagreement with you as only possibly coming from one source. You’re operating on the mistaken assumption that “if only they knew this or if only they read this, they would certainly think like me instead of how they think now.” You’re making an arrogant assumption of how compelling the information on “your” side is. Ever consider that they might genuinely disagree with you and for any number of reasons? This is again a symptom of the “they’re brainwashed” narrative you clutch to in order to make sense of their possible disagreement with you. You have to avoid that. I’m not arguing against reading primary sources, Simon. I’m arguing against your eagerness to jump to certain trite conclusions about your peers. I don’t think judging them on what they’re going to say publicly within China is enough to damn them as not being “interested with truly informing themselves.” There are confounding factors that may influence their expression in China that you have to account for. You need to win their confidence and they have to feel safe in opening up to you. Think of it as an experiment and how you control for other factors to get the real data you need to arrive at scientifically rigorous conclusions. You’re jumping to conclusions. Have they read it? Why not? Why won’t they? If they have, what do they think? would they tell you the truth? Why or why not? If they haven’t, again, why not? Do the reasons then suggest that they’re not interested in informing themselves or does it suggest something else? The rest of your reply is just silly so I won’t go into that, judg ing from the votes some oth ers would prob a bly agree. Kai Pan, you’re still not reading what I wrote. I explicitly said it’s ok and perfectly valid to disagree, but you need to know what you’re talking about. I also stated that it’s they themselves who said that they didn’t inform themselves from secondary sources nor read the primary source, I am not “assuming so based on my prejudice”, that’s your own fabrication. The rest of your arguments go along the same lines, you’re attacking a strawman. If you reread what I initially wrote you can clearly see that it’s not the disagreement with their opinions that disheartened the professor (and us Internationals) but their blissful ignorance on the topic, despite being so outspoken in their criticism of the person. Not a single one of them could answer inquisitive questions from the prof to find out why exactly they think so. Blindly following the governments’ official line without a clue is pretty brainwashed I think. And mind, I had many good discussions with Chinese scholars and students, I just tried to highlight that those students who should know the most about these issues often have no clue, if my University is any indication, and that this is exactly the problem as others have highlighted. What “opinion” are you referring to? Note that I’m not accusing you of disagreeing with Chinese people feeling that it is not THAT bad to live in China. I’m disagreeing with your generalizations that Chinese people “aren’t interested in truly informing themselves” simply because they didn’t seem to share your opinions on Liu and Charter 08 when asked in a university class in China. Second, I already addressed the confounding factors with their responses on whether or not they read from non-Chinese sources. As I said, given the sensitivity surrounding the issue, that someone is in JAIL for it, I’m not surprised. You’re taking it at face value. I already warranted that some, even many, of them may indeed be guilty of what you accuse (did I not?), but you’re not that stupid. Consider the circumstances. I never said that you or the professor or other “internationals” were “disheartened” by their disagreement, did I? I disagreed with your rush to jump to the conclusion that they are “brainwashed media illiterates”. Who is the one that needs to reread what who wrote and who is the one attacking a straw man? their blissful ignorance on the topic, despite being so outspoken in their criticism of the person. How were they outspoken? Did they bring up the subject? No, the professor did, to a group of young Chinese nationals inside China with a vested interest in protecting their futures. They’re not like you, Simon. Like Fauna, they don’t have a foreign passport and government to protect them from getting mixed up with Liu and Charter 08. So yet again, I’m not surprised by their responses. And really, what characterizes their public “ignorance” as “blissful” anyway? How do you know they are “blindly” following the government’s line versus toeing the government’s line in self-interest and self-preservation? I brought all of this up already. It is your eagerness to assume brainwashing over self-interest that leads me to accuse you of assuming based upon your own prejudice. You are making faulty assumptions about the students who “should know the most about these issues” based upon how they respond in uncontrolled situations. It’s like asking a husband if he’s ever cheated right in front of his wife. Even if he has, there’s a high probability that he’s not going to admit it. A more nuanced situation is breaching contentious political subjects with people who are distrustful of your motives and intent. You know this, don’t you? Or do you really think people are always going to say what they really think? That they don’t tailor their answers to the circumstances or to how they feel about the other person? I’m asking you to consider these factors before jumping to generalizations about how “interested” they are in “truly informing themselves”. The “they’re brainwashed” narrative is such a cop-out. There is enough evidence of Chinese people, especially educated Chinese people, being capable of thinking critically about politics. No one is denying that there is plenty of evidence that there are plenty of educated Chinese people who aren’t, but why the rush to judge when there are so many confounding factors to consider? More of my less
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329, 2264, 273, 608, 13, 24341, 28833, 11640, 1119, 2439, 1722, 8837, 14278, 273, 495, 13, 20487, 2985, 1215, 13, 337, 13, 29185, 11561, 13, 19593, 25333, 13, 13620, 801, 1241, 285, 12708, 37690, 2670, 9197, 15, 322, 8977, 9197, 275, 3608, 3786, 2361, 281, 320, 12059, 275, 9391, 1559, 14630, 2923, 13, 1690, 18902, 9197, 275, 475, 12261, 3357, 11, 313, 1671, 15, 19, 2673 ]	SDS‐PAGE gel, the transfer was verified using Ponceau S (Sigma), transferred to nitrocellulose membrane and blocked in Tris‐buffered saline containing 5% BSA (Sigma) and 0.05% Tween‐20(Sigma). The primary antibody against Total HER2 (sc‐33,684 Dilution 1:500), Total EGFR (1005) (sc‐03 Dilution 1:500), Total ERK2(C‐14) (sc‐ 154 Dilution 1:500) and β‐Actin(I‐19)‐R (sc‐1,616‐R Dilution 1:3000) were obtained from Santa Cruz biotechnology. The primary antibodies Phospho‐HER2 (Tyr1248) (AP0152 Dilution 1:500) from Abclonal and Phospho‐p44/42 (T202/Y204) MAPK (\#4370) Dilution 1:1000), Phospho‐EGFR (Y1068) (\#2234 Dilution 1:500) were obtained from Cell signaling technology respectively. Thiazolyl blue tetrazolium bromide (MTT, TC191) was obtained from Hi‐Media. Receptor tyrosine kinase proteome array {#ijc31916-sec-0015} --------------------------------------- The relative amount of 49 tyrosine kinases were evaluated using Proteome Profiler Human Phospho‐ RTK array kit (ARY001B -- Proteome Profiler, R&D systems) and the protocols were followed as per manufacturer\'s recommendation. Briefly, cells were harvested, washed with 1X PBS and lysed after which 400 μg of protein was mixed with a buffer and incubated with preblocked nitrocellulose membrane at 4 °C. Subsequently, the membranes were probed using detection antibodies and probed using streptavidin‐HRP, after which signals were developed using the chemi‐reagents provided with the kit. The Pixel density of each spot in the array in duplicate was quantified using Image J macro‐Protein array analyzer plug in. The average pixel density of the duplicate spots for each of the kinases was subtracted from the negative density and was plotted, as detailed earlier.[35](#ijc31916-bib-0035){ref-type="ref"} Invasion assay {#ijc31916-sec-0016} -------------- Invasion ability of the cells was assessed in Transwell system using cell culture inserts for 24 well plates with 8 μm pores (BD Biosciences, NJ). The upper side of the cell culture insert was coated with Matrigel (BD Biosciences, San Jose, CA). GBC cells were seeded at a density of 2 × 10^4^ on the upper side of the coated Matrigel in presence of serum free DMEM. Complete DMEM media with 10% FBS was added to the lower side of the insert and were incubated at 37 °C in 5% CO~2~ incubator for 12‐14 h. Post incubation the non‐migratory cells on the lower side of the cell culture insert were removed using a cotton swab. The transwell chambers were fixed and stained with 0.1% crystal violet. The invasion ability was estimated by counting the cells that have migrated to the lower side of the cell culture insert. Cells in visual field with a magnification of 20X were counted in each Transwell chamber in triplicates. Wound healing assay {#ijc31916-sec-0017} ------------------- Confluent monolayers in 6‐well plate were subjected to scratch with a sterile pipette tip. After this, cells were washed with 1× PBS to remove debris and subsequently incubated with media. Cell migration at the wound surface was measured during a period of 20 h under an inverted microscope. The quantification of cell migration was done using Cell Profiler[36](#ijc31916-bib-0036){ref-type="ref"} wound healing pipeline for three independent wounds in three independent experiments. Immunohistochemistry {#ijc31916-sec-0018} -------------------- Immunohistochemical analysis was done using the standard protocol of Vectastatin Universal kit. Briefly, antigen retrieval was performed by incubating the slides in preheated citrate buffer (pH 6) using a pressure cooker for 10 min. The slides were allowed to cool at room temperature before rinsing with TBST (Tris‐Buffered saline‐ Tween 20 (1%). The endogenous peroxidase activity was blocked by incubating the slides in 3% hydrogen peroxide. The slides were blocked by horse serum for 1 h before incubating with the primary antibody (HER2 DAKO A0485, Phospho‐p44/42 (T202/Y204) MAPK \#4370, Total ERK2(C‐14) sc‐154) for overnight at 4 °C in moist chamber. Post incubation the slides were rinsed with TBST and incubated with universal secondary antibody (Vectastatin). The chromogenic reaction was performed using 3′‐3′‐ diaminobenzidine chromogen solution for 5 min which results in brown signal. The slides were rinsed in deionized water and counterstained with hemotoxylin. Finally, the slides were dehydrated and mounted with a mounting medium and cover slip. Coimmunopreciptation assay {#ijc31916-sec-0019} -------------------------- For immunoprecipitation, cells were harvested in NP‐40 lysis buffer (50 mM Tris pH 7.4, 150 mM NaCl, 0.5% NP‐40, 1 mM EDTA along with protease and phosphatase inhibitors), Protein lysate supernatant were combined with the anti‐EGFR antibody and incubated overnight on a rotator at 4 °C. Protein G‐Sepharose beads (50 μL) were added to the cell lysates the next day and were on a rotator at 4 °C for 4 h. The Protein G‐Sepharose beads were isolated by centrifugation at 2000g for 2 min. Further, these beads were washed three times with NP‐40 lysis buffer and heated for 10 min at 100 °C in loading buffer. Samples were run on SDS‐PAGE and then probed by immunoblot for HER2. In vivo study {#ijc31916-sec-0020} --------------- Five‐ to six‐week old female NOD‐SCID mice were injected subcutaneously with 3 × 10^6^ cells/mL in 100--200 μL PBS G415 (N = 13), NOZ (N = 10) and OCUG1(N = 10). After injecting the cells, the size of the resulting tumors was determined every third day using calipers. Afatinib inhibitor was administered to the randomized group of mice by oral gavage at 15 mg/kg body weight along with vehicle control (1% Tween 80) for a period of 15 days after the tumor volume has reached between 100 and 150 mm^3^. micro PET‐CT scan was performed at the end of drug treatment. The tumor volume was calculated using the formula -- (Width^2^ \* Length) /2. After 15 days, the mice were euthanized with CO~2~. Tumors were excised and tissues were stored for molecular and histopathological analysis. Statistical analysis {#ijc31916-sec-0021} -------------------- Prism software (GraphPad) was used to analyze proliferation and drug sensitivity of cells to inhibitors, and to determine the statistical significance of differences between the groups by applying an unpaired Student\'s t test. p Values \<0.05 were considered significant. The Kaplan--Meier estimation of patient survival and correlation analysis were assessed using R packages survival (<http://cran.r-project.org/package=survival>), and IBM SPSS v20. Study approval {#ijc31916-sec-0022} -------------- The study protocols were approved by ACTREC‐TMC Institutional Review Board, Project \#104. The animal study protocols were approved by Institutional Ethics Animal Committee of ACTREC. Availability of Supporting Information {#ijc31916-sec-0023} -------------------------------------- The datasets supporting the results of this article are available from the ArrayExpress database (accession number E‐MTAB‐6619). Results {#ijc31916-sec-0024} ======= Integrated genomics and proteomics approach identify aberrant alterations in members of the EGFR family in gallbladder cancer {#ijc31916-sec-0025} ------------------------------------------------------------------------------------------------------------------------------- We performed whole‐exome sequencing on paired tumor and germline DNA samples from 17 patients with gallbladder cancer and 5 gallbladder cancer cell lines (Supporting Information Table [S1](#ijc31916-supitem-0001){ref-type="supplementary-material"} and [S2](#ijc31916-supitem-0001){ref-type="supplementary-material"}). We achieved \>100‐fold mean sequence coverage of targeted exonic regions. The average nonsynonymous mutation rate was found to be 7.7 mutations per megabase (Supporting Information Table [S3](#ijc31916-supitem-0001){ref-type="supplementary-material"}), which is significantly higher than as reported for other populations.[37](#ijc31916-bib-0037){ref-type="ref"} The nucleotide mutation pattern was observed to be enriched for C\>T transition followed by A\>G transition (Supporting Information Fig. [S1](#ijc31916-supitem-0001){ref-type="supplementary-material"}), consistent with previous reports.[37](#ijc31916-bib-0037){ref-type="ref"} A total of 5,060 somatic variants found across 17 tumors consisted of 3,239 missense, 1,449 silent, 131 nonsense, 135 indels and 106 splice site mutations. Somatic mutations in genes previously reported to be altered in gallbladder cancer, including recurrent mutations in TP53 (35.2%)
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355, 15, 17734, 13, 247, 1029, 14, 14729, 8121, 323, 8109, 3345, 7424, 432, 1894, 18035, 310, 14998, 15, 496, 436, 673, 13, 253, 1643, 1783, 27599, 10256, 407, 247, 3440, 273, 42855, 2586, 20586, 273, 20533, 14846, 13, 285, 247, 27541, 5239, 14, 3169, 1635, 3249, 644, 281, 452, 253, 2570, 4893, 15, 380, 1055, 875, 253, 1027, 3382, 20937, 342, 611, 14, 30799, 13, 3492, 878, 13, 285, 401, 25693, 14, 36, 10722, 556, 1060, 644 ]	interacted while they made relating rigorous treatments. 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18029, 281, 15, 309, 1053, 626, 871, 604, 352, 434, 253, 806, 275, 253, 2962, 390, 417, 13, 533, 352 ]	gotten what he needs, so he moves to the next place, the next job, the next attempt to find something worth staying for, always landing at the top of his game, but never feeling like he belongs. A Restored Man: The Men of Halfway House, Book 3 Cole Renzo thinks his greatest challenge is to behave for the remainder of his term at Halfway House. Until he meets his new boss, Ty Calloway, a man who ticks off every box on Cole's list of interests. A sought-after restorer and customizer of exotic and collectible cars, Ty had enough confidence to command what he wanted in life, until one fateful night changed everything. Almost two years later, he's slowly rebuilding his life with great control. He's defied the odds and works tirelessly to be the man he once was - but he still feels broken. The Truth as He Knows It: Perspectives, Book 1 Officer Noel Carlson isn't out to anyone in small-town Stratton, Pennsylvania, so a relationship is out of the question. That doesn't stop him from wanting one, though. When a night-shift call brings him face-to-thonged-butt with a hired stripper whose girl-party gig went terribly wrong, Noel takes pity on the guy and lets him go. But he can't get the encounter out of his mind. Breakaway: Scoring Chances, Book 1 Drafted to play for the Jacksonville Sea Storm, an NHL affiliate, 20-year-old Lane Courtnall's future looks bright, apart from the awkwardness he feels as a gay man playing on a minor league hockey team. He's put his foot in his mouth a few times and alienated his teammates. Then, during a rivalry game, Lane throws off his gloves against Jared Shore, enforcer for the Savannah Renegades. It's a strange way to begin a relationship. Crossing Borders Tristan knows he's got issues. His latest ex-girlfriend knows it too. He can't blame her for dumping him - even though she gets her brother to do it for her. Since he can't stop staring at said brother's package, he figures it's about time to put a label on those issues. He likes guys. He heads to a local bookstore with what he's sure is a foolproof plan to find someone to show him what he's been missing. But who should crash his little adventure? Officer Michael Truax, who gave him a really expensive ticket back in high school. Publisher's Summary Ten years ago David Worral had plans to go to college and the potential for a beautiful future in front of him. One tragic accident later, he fled to California and reinvented himself as Dex, top porn model of Johnnies. Dex's life is a tangled mess now, but the guys he works with only see the man who makes them believe even porn stars can lead normal lives. When Kane, one of Dex's coworkers, gets kicked out of his house, the least Dex can do is give him a place to stay. Kane may be a hyperactive muscle-bound psycho, but he's also a really nice guy. What could be the harm? Except nothing is simple - not sex, not love, and not the goofy kid with the big dick and bigger heart who moves his life into Dex's guest room. When they start negotiating fractured pasts and broken friends, Dex wonders if Kane's honest nature can untangle the sadness that stalled his once - promising future. With Kane by his side, Dex just might be able to reclaim the boy he once was - and if he can do that, he can give Kane the home and the family he deserves. Loved this book. Amy Lane at her best - I think this will be a great series of books. A particularly sexy instalment. Can't wait for the next one. 3 of 3 people found this review helpful Kindle Customer The Woodlands, TX 21/04/14 Overall Performance Story "Read it already, but bought the audio," Would you listen to Dex in Blue again? Why? Yes, read the book then bought the audio. This is a tie between the first and the second in the series. I love Chase in Dark and I love this one. Sean Crisden is one of my favorite narrators and he does not disappoint in this one. Who was your favorite character and why? ?? I love them all, Dex (David), and Kane (Carlos). I love this relationship, and I love Dex in his role in Johnnies. When he slept with Tommy in the first book, I had a problem with loving him, but quickly got over it. Have you listened to any of Sean Crisden’s other performances before? How does this one compare? Many by this narrator. Great as always. He can turn a bad book into a good listen just due to his narration. Who was the most memorable character of Dex in Blue and why? Dex and Kane, I do love Ethan and cannot wait until his comes out. Any additional comments? Worth the money, now I own the book and audio, I will listen again and again. 3 of 3 people found this review helpful Heather Seattle, WA, United States 18/04/14 Overall Performance Story "More of Johnnies boys falling in love." This story is the 2nd story Amy wrote about the boys from Johnnies. Dex's story starts long before you meet him in Chase in Shadow, giving us his back ground, but it quickly becomes concurrent to Chase and Tommy's timeline. While the title states Dex, the story is about both Dex and Kane falling in love and making it work. You will love Kane's innocence and Dex's strength. Families are what we make them - and Amy makes them amazing! 3 of 3 people found this review helpful Belen United States 17/02/16 Overall Performance Story "Wonderfully narrated by Sean Crisden" Any additional comments? This is wonderfully narrated by Sean Crisden! I enjoyed the character voices, the pacing, the intimate scenes, as well as most of the story. Which is great, because I was really looking forward to David/Dex's story, and getting to see him fall in love with Carlos/Kane was a treat. David "Dex" Worral has been working for Johnnies for nine years and has become the right hand man who keeps everything afloat. It's Dex who schedules and handles most of the business. While his professional life is right on track, and it's true he's doing really well, it seems like the only thing missing from Dex's life is someone to love who loves him back. As it happens in romances, a character sometimes has to be with someone not worthy in order to see the guy who is worthy. After breaking up with his douche-nozzle ex, the "right" guy finally comes along and when Carlos "Kane" Ramirez shows up on Dex's doorstep needing a place to stay, it turns into more between the two quickly, and they fall in love. It was a really sweet thing to witness the two bond and be there for each other through thick and thin. I love these two characters! The only negative for me was I felt like much of the last quarter was unnecessarily over-dramatic. It put me off the flow of the story and jarred me. I really didn't see the need and it felt like a sort of "Oh, things are going too well for the characters, I have to throw some angst in here!" and then a whole bunch of things happen that didn't feel organic to the story. Bottom line: I enjoyed the story, the characters, and especially the narration. I would not hesitate to recommend this to anyone looking for a romance with a medium-level of angst, sweetness, hot sexy times, and likable characters. Recommended. 2 of 2 people found this review helpful Marilyn GLASTONBURY, CT, United States 09/07/14 Overall Performance Story "A well-told, heart-warming story from the get-go" The story is about a young gay man who comes to understand who is he and what it will take to get out of life what he wants and deserves. It is not a heavy or deep story, but accurate and meaningful in terms of the feelings and growth involved. You will come to love both the main characters as well as the background ones, who each have their own book in the series. My only criticism is the reader. His voice seems more mature than the characters' ages are supposed to be. At times he adopts a childish lilt/tone to account for that or differentiate between different character's voices. Also, one of the main characters has an LA Mexican way of talking that the narrator can't quite pull off (mainly to the aforementioned childish lilt, which makes the character sound like a whiny child). I did, however, get used to his voice and found that it didn't detract so much as it left me just wishing it were different/better. This is the first book in this series that I listened to. I don't know if it's the first in the series or not, but it
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"That's the mandate of Spacing, to help make Toronto better," he said of the ideas he's suggested to transit officials. "Each time I present them they say, `This is a great idea,' and that's the end of it." Blackett tried to persuade the TTC to merchandise the station-stop buttons Spacing created. But officials wouldn't listen to his pitch, he said. Now there are about 120,000 buttons in circulation. The panel's recommendations will be based on a review of employee customer service training; the TTC's complaint process; hiring criteria for frontline workers and a customer charter of rights. The Toronto Star and thestar.com, each property of Toronto Star Newspapers Limited, One Yonge Street, 4th Floor, Toronto, ON, M5E 1E6. You can unsubscribe at any time. Please contact us or see our privacy policy for more information. More from the Toronto Star & Partners LOADING Copyright owned or licensed by Toronto Star Newspapers Limited. All rights reserved. Republication or distribution of this content is expressly prohibited without the prior written consent of Toronto Star Newspapers Limited and/or its licensors. To order copies of Toronto Star articles, please go to: www.TorontoStarReprints.comdeprecated: true # moved to stable name: kubewatch version: 0.2.3 appVersion: v0.0.3 description: DEPRECATED Kubewatch notifies your slack rooms when changes to your cluster occur home: https://github.com/skippbox/kubewatch keywords: - kubernetes - slack sources: - https://github.com/skippbox/kubewatch engine: gotpl Introduction {#S1} ============ Essential tremor (ET) is a neurological condition that causes shaking or rhythmic motion in body parts. ET is characterized by a positional and/or volitional 4- to 12-Hz tremor that can affect all body parts ([@B40]) and affects nearly 1% of the world's population, increasing to 4% of those over age 40 ([@B43]). Although the preferred treatment for ET is pharmacology based, medications for ET may decrease in efficacy over time or not be efficacious ([@B7]). It is estimated that pharmacological treatment can improve tremor in only 50% of patients ([@B38]). Therefore, deep brain stimulation (DBS) becomes an alternative treatment option when medication is not effective or not tolerated in patients with disabling tremor ([@B63]; [@B10]). Ventral intermediate nucleus of the thalamus (VIM) is a well-established DBS target for ET ([@B12]), because the VIM is a cerebellar relay nucleus in the ventrolateral (VL) part of the thalamus and is known to be involved in ET ([@B2]; [@B26]; [@B52]). The VIM shows abnormal neuronal discharges in humans with ET ([@B12]). The cerebral cortex is also a part of the tremor-generating neuronal network ([@B25]; [@B50]). The corticothalamic anatomical connections are well established ([@B50]; [@B49]). Thalamic neurons receive robust input from corticothalamic feedback neurons, thereby allowing the cortex to communicate continuously with the thalamus during sensory processing ([@B5]). Corticothalamic feedback neurons reside in cortical layer 6 and give rise to axons that terminate both in the thalamus and in the layers of the cortex receiving thalamic input ([@B54]; [@B58]). Recently, several studies have suggested that cortical thickness could be used as an ET diagnosis with a high accuracy ([@B9]; [@B6]; [@B53]; [@B3]), which may partly reflect a decrease in the amount of corticothalamic connections. In the study of connectivity for the cerebello-thalamo-cortical network in humans, when tremor is severed, M1 has reduced cerebellar functional connectivity, whereas the thalamus has increased cerebellar functional connectivity ([@B33]). Thus, there is evidence for alterations in cerebello-thalamo-cortical circuit activities directly influencing ET. In the neurophysiological view, rhythmic firing patterns such as oscillations and bursts have been considered as a way to process information in the brain ([@B57]; [@B28]). Therefore, we hypothesized that DBS at the VL thalamus (VLT), which is a homolog of VIM in humans, may act through changing neuronal firing patterns in the primary motor cortex (M1). To test our hypothesis, we investigated changes of M1 neuronal activities while high-frequency VL thalamic DBS (130 Hz) was applied in harmaline-induced tremor rats. Here, we demonstrated that four neuronal discharge patterns exist in M1 and VLT and those were changed by harmaline. Our data also show that high-frequency thalamic DBS changed the proportion of four different firing patterns of M1 activities; and these changes have a residual effect, which was maintained even after the termination of DBS in harmaline-administered rats. Materials and Methods {#S2} ===================== Animals {#S2.SS1} ------- Subjects were adult Sprague--Dawley rats weighing 270--350 g (34 rats for behavior only, 8 rats for M1 recording, 15 rats for VLT recording). Animals were maintained under standard laboratory conditions on a 12/12-h light/dark cycle (lights on at 7:00 a.m.), and they had free access to food and water. All experimental procedures were approved by the Mayo Clinic Institutional Animal Care and Use Committee for experimental animals. Tremor Induction and Measurement {#S2.SS2} -------------------------------- Tremor was induced by intraperitoneal (i.p.) injection of harmaline (harmaline HCL, Sigma-Aldrich, St. Louis, MO, United States). Harmaline was dissolved in saline and administered at a dose volume of 5, 7.5, 10, and 20 mg/kg. Tremor was measured with the force-plate actimeter (FPA, BASi, Lawrence, KS). A force-sensing actimeter was confined to a horizontal sensing area by an enclosure suspended a short distance (2 mm) above the upper surface of the force plate (440 mm^2^ × 440 mm^2^) ([@B19]). Four force transducers existing below the corners of the plate recorded the animals' position on a Cartesian plane and measured the force exerted on the plate at each time point. Data were collected and stored in the duration of 10.24 s as 1 frame with 100 points per second as a sampling frequency. Rats were placed on the force plate, and their movements were measured for 4 h 16 min (1,500 frames). Harmaline was injected following 20 min of movement recording for a baseline. The experiment was performed over five consecutive days. DBS Electrode Implantation Surgery and Application {#S2.SS3} -------------------------------------------------- Rats were anesthetized with 2--3% isofluorane and mounted in a stereotactic device (David Kopf Instruments, Tujunga, CA, United States). Two screws were located on the skull for attaching the electrode. Customized concentric bipolar electrodes were 1.07 mm in the diameter of the outer shell, and the inner and outer cores were made with stainless steel wires, 300 and 700 μm in diameter, respectively. The electrode was stereotactically implanted into the VLT \[anterior--posterior (AP) -- 2.3 mm, medial--lateral (ML) ± 1.8 mm from the bregma, and dorsal -- ventral (DV) -- 5.6 mm from the brain surface, according to the [@B48] rat brain atlas. The electrode was attached to the skull with screws using dental cement. After implantation surgery, the animals were placed in a cage for at least 1 week to recuperate. After full recovery from the electrode implantation surgery, the animals were placed in a force-plate actometer. The electrode was connected to a stimulus generator (AM system, World Precision Instruments, Sarasota, FL, United States). After 20 min of baseline movement recording, high-frequency stimulation (130 Hz, rectangular pulse width 100 μs) was applied for 10 min followed by 10 min off stimulation. After that, low-frequency stimulation (10 Hz, rectangular pulse width 10 μs) was applied for 10 min followed by 10 min off stimulation. Then, harmaline was administered intraperitoneally at a dose of 10 mg/kg; and 30 min later, the stimulation procedure described above was repeated. Tremor Analysis {#S2.SS4} --------------- Tremor data were filtered by the Hanning window and converted to power spectra of frequency by a fast Fourier transform (FFT) on each frame of the experiment using MATLAB (MathWorks, Cambridge, MA, United States). For each frame, the total motion power from 0 to 25 Hz (full motion spectrum) and the motion power from 8 to 12 Hz (the harmaline-induced tremor frequency bandwidth) were calculated. Next, the power spectra from 8 to 12 Hz was divided by the power spectra 0--8 Hz for each frame ([@B41]). Then, the resulting motion power ratio (MPR) for each 10-min epoch was generated by averaging the data from 1 frame. Each 10-min MPR was normalized by the averaged 20-min baseline MPR. Electrophysiological Recordings and Stimulation {#S2.SS5} ----------------------------------------------- Electrophysiological experiments were performed in anesthetized rats with urethane (1.5--1.6 g/kg
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326, 629, 273, 521, 1495, 310, 689, 285, 48801, 310, 665, 344 ]	ilogue--I'm a sucker for epilogues anyway but this one was beautiful! BOOK SUMMARY... Nina is 36. She's blonde headed, with hazel eyes and very pretty. She lives in England and is an attorney. She's engaged to a douchbag who doesn't care about her at all. She's very put together, almost to the point of snooty in the beginning. She' was a strong character. She didn't take crap from anyone including Max at times. She had no problem standing up for others or herself. She had a "take on the world" feel to her and I loved her instantly. Max is 37. he's tall with broad shoulders, dark wavy hair, and grey eyes. He is the owner of the house Nina is going to rent while she's on vacation. He's dark and imposing in the beginning, very unapproachable. He's domineering, possessive, and a bit controlling...in and out of the bedroom. He sees something he wants and he goes for it. He was married 10 years before but lost his wife in a car accident and has since played the field thinking he'd never find love again. Nina is taking a break from her life. She's left her fiance, her life, and everything else behind for 2 weeks. Her plans are to get to the house she's rented and sort through her feelings. She's has a fiance named Niles who could care less that she's gone. He doesn't call to make sure she made it safely or anything. It's snowing and she's getting sick. All she can think about is getting to her destination and going to bed. Once at the house, she realizes there is a mix up. The owner is home and the booking was wrong. He's a jerk and sends her own her way. She being the person she is, has no intention of going down with a fight. They fight outside in the snow, he tells her to stay the night, and she's so stubborn she refuses. She ends up in a ditch not far from his house. She's had enough and takes some medicine and falls asleep in the backseat praying someone will find her. The following morning she wakes up in Max's bed in the house she left the following night sick as a dog. Like death flu sick. Over the next several days Max takes care of her. He feeds her, makes sure she's taking medicine, and when she's shivering uncontrollably he gets into his bed with her and holds her until she's calm again. She's out of it but knows some of what's going on. Following her illness she wakes up mortified with one thought...Get far far away. There's just one problem with her plan to leave...Max won't let her. She needs her rest and she's staying, end of story. He's goes so far that he takes her keys and calls the cab company and tells them not to come get her if she calls while he's out. For her nothing has changed but for him, he's spent the last 48 hours taking care of him and now he wants to get to know her. He flirts and lets her know that if she were his... "If you told me you needed a timeout, first, I wouldn't f*in let you have one, second, I wouldn't give you reason to fin want one, last, you took off anyway, I'd f**in phone." He takes her to dinner which ends up being their first date. He's trying to get to know her but she argues with him about everything. Seriously they even argue about the nationality of beer. We meet Shauna, who is a woman Max used to sleep with. She's a horrible person and I couldn't stand her. Once back at the house she goes to bed and wakes up in his arms. When she tries to pull away, he pulls her back to him. She's still set on leaving but he kisses her. The following morning he takes her to his "spot" which is a bluff on his mountain. He doesn't take a lot of people there but he took her only having known her a few days. Following their day together, she sends Niles a "dear John" letter home through an email, ending her 2 year relationship. They begin spending time together, sleeping curled around each other every night. He is constantly calling her "his woman". It's sweet. (Yes, I'm going all swoony on you) We meet Mindy and Becca. Mindy is Max's best friend's (Brody) little sister. Nina gets the wrong idea but Mindy is like his little sister. Becca is Mindy's best friend who is also close to Max. We find out that Nina's brother was hurt in the army. He lost his legs and in coming home lost everything else he valued. He gave up and committed suicide. Having the wrong idea about Mindy, Nina delivers this information rather bluntly and harshly. When she leaves the room, Max lets Nina know who she is and what she means to him. He then tells her she was harsh and that Mindy had been raped 3 weeks prior and didn't need that from her. Her and Mindy get to know each other and end up having a girls night with a few other females in town. Mindy's boyfriend is a total douchebag and blames Mindy for what happened. When he gets ugly with Mindy, Nina jumps in and ends up getting backhanded across the face. Max walked in a the exact moment this happens and beats the crap out of him. Max is trying his best to spend time with her alone but they are constantly interrupted. Max isn't a fan of being interrupted. Nina is fully aware of what Max wants their alone time to consist of. He has no problem letting her know that he wants to be with her. On the way to dinner he tells her he wants her to move to Colorado, live in his house, and start a life with him. (It's not even been a full week!) She isn't quite getting it yet but he has no intention of letting her go now that he has her. She's officially been claimed. We find out about Max's wife when Nina discovers their picture at Bitsy's house (friend of Max and wife of the man who was married earlier in the book...didn't mention it because I really didn't see the point). She can tell how happy they were and how much he loved her. She gets this idea in her head that if he has already been with the love of his life then she can never be that for him. Without even talking to him she makes the decision to not even try. She's trying to run and he's trying to plan their future. He knows somethings up but can't get through to her. At dinner they run into Shauna again. This confrontation was funny. Her dad shows up in town and she gets in a screaming match with him and slaps him. Max has to pull her back. This girl is feisty when she's mad. Her mom and step dad show up and he and Max go to talk to her father. Max finds out at the meeting that Niles is on his way to town and they have to meet with them the following morning. It doesn't go well. Niles shows his true colors and we find out that her dad offered Max $250,000 to walk away. Mindy tries to commit suicide but they get to her in time and Nina takes over showing how strong she is. She rushes into the water and pulls her out then performs CPR. She promises her she'll help her get the help she needs and eventually does. When she and Max are finally alone, he's angry that she jumped in the water. They fight, make up and then finally have sex. It's hot and he's so dominate with her. Now that they have officially done the deed, she's his and he has no intention of letting her walk away. Anna gets the full story about Max and Anna from a very drunk Harry (another friend of Max) and he's none to nice about it. Tells her she'll never be Anna and that he'll never love her the way he loved Anna. She shuts down and won't talk to him. She's planning on getting through the night and leaving the next morning. Max hears a recorded conversation with Bitsy and realizes that Nina already knows about Anna while he's been trying to figure out how to tell her. He's so angry and says some really mean things. He pretty much tells her they are done and walks away. She being Nina packs up her things and takes off to a cabin in the woods. Damon, Mindy's boyfriend she hit, finds her and beats the crap out of her. I mean seriously this girl goes on vacation and it sucks (minus hot, sexy mountain man who claims you)! "I mean, I go on a vacation to try to figure out my life and here I am, my legs's scraped up, my ribs are bruised, I've been backhanded and punched, I've been to a hospital once and a Police Station three times and I've been into it with practically everyone in town and, if you take out the time I've been sick, I've only been here a week!""I need a timeout to deal with my timeout!" Max began tracking her down the minute he realized she was gone (about the moment he cooled off and realized he needed to talk to her) and when he finds her and sees the damage he's angry. After a trip to the hospital he finally talks to her about Anna and then tells her that part of his life is over and Nina is who he
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44, 393, 3442, 393, 1588, 92, 54, 2000, 74, 5709, 1464, 30537, 3124, 16489, 187 ]	flow wake are utilized for the calibration. This work is only one piece in the complete process of calibration and validation of LES models to issue predictions of QoIs with quantified uncertainties, and many open questions remain. We do not attempt to fit the numerical solutions with physical data herein, as the two-dimensional model has been known to show remarkable discrepancy with the experiment results. Applying our framework to the three-dimensional simulation for parameter calibration against real-world data would be the next logical step. [Another important problem is to evaluate and compare the performance of our AHSG with other surrogate methods (including some listed above) in this process. This would be conducted in future research.]{} [Also,]{} characterization and quantification of the structural inadequacy and comparison of different competing LES models are beyond the scope of this study. The rest of the paper is organized as follows. The Bayesian framework and the adaptive hierarchical sparse grid method of constructing the surrogate system are described in §\[sec:surrogate\]. In §\[sec:les\], we give a detailed description of the Smagorinsky model of sub-critical flow around a cylinder. The performance of surrogate modeling approach and results of the Bayesian analysis are presented in §\[sec:result\]. Finally, discussions and conclusions appear in §\[sec:conclusion\]. Adaptive hierarchical sparse grid methods for surrogate modeling in Bayesian inference {#sec:surrogate} ====================================================================================== Bayesian inference ------------------ Consider the Bayesian inference problem for a turbulence model $$\begin{aligned} \label{def} \bm{d} = \bm{f}(\bm{\theta} ) + \bm{\varepsilon},\end{aligned}$$ where $\bm{d} = (d_1,\ldots, d_{N_d})$ is a vector of $N_d$ reference data, $\bm{\theta} = (\theta_1, \ldots,\theta_{N_\theta})$ is a vector of $N_\theta$ model parameters, $\bm{f}(\bm{\theta})$ is the forward model, e.g., Smagorinsky model (see §\[sec:les\]), with $N_{\theta}$ inputs and $N_d$ outputs, and $\bm{\varepsilon}$ is a vector of residuals, including measurement, model parametric and structural errors. [(Nonlinear model $ \bm{d} ={\bm \Xi}(\bm{f},\bm{\theta},\bm{\varepsilon})$ can be considered as well, but leads to more complicated likelihood functions, as $\bm{\varepsilon} = \bm{\Xi}^{-1}(\bm{f},\bm{\theta})(\bm{d})$).]{} The posterior distribution $P(\bm{\theta}\|\bm{d})$ of the model parameters $\bm{\theta}$, given the data $\bm{d}$, can be estimated using the Bayes’ theorem [@BT92] via $$\label{s2:e2} P(\bm{\theta}\|\bm{d}) = \frac {L(\bm{\theta}\|\bm{d})P(\bm{\theta})}{\int L(\bm{\theta}\|\bm{d})P(\bm{\theta})d\bm{\theta}},$$ where $P(\bm{\theta})$ is the prior distribution and $L(\bm{\theta}\|\bm{d})$ is the likelihood function that measure “goodness-of-fit” between model simulations and observations. In parametric uncertainty quantification, the denominator of the Bayes’ formula in equation is a normalization constant that does not affect the shape of the PPDF. As such, in the hereafter discussion concerning building surrogate systems, the notation $P(\bm{\theta}\|\bm{d})$ or the terminology PPDF will only refer to the product $L(\bm{\theta}\|\bm{d})P(\bm{\theta})$. The prior distribution represents knowledge of the parameter values before the data $\bm{d}$ is available. [When prior information is lacking, a common practice is to assume uniform distributions with parameter ranges large enough to contain all plausible values of parameters.]{} Selection of appropriate likelihood functions for a specific turbulence simulation is an open question. A commonly used formal likelihood function is based on the [simplistic]{} assumption that the residual term $\bm{\varepsilon}$ in follows a multivariate Gaussian distribution with mean zero and prescribed standard deviations, which leads to the Gaussian likelihood function: $$\begin{aligned} L(\bm{\theta}\|\bm{d}) = \exp\left[-\frac{1}{2}(\bm{d}-\bm{f}(\bm{\theta}))^{\top} \Sigma^{-1}(\bm{d}-\bm{f}(\bm{\theta})) \right]. \label{MVN} \tag{MVN}\end{aligned}$$ In this paper, we assume that the residual errors are independent, i.e., the covariance matrix $\Sigma$ is diagonal. [To describe the correlation of the errors or the inadequacy of turbulence models, other covariance matrices can also be used (and lead to inconsistent results) [@COP+11; @OM11].]{} In general, the formal approach has been criticized for relying heavily on residual error assumptions that do not hold. Alternatively, informal likelihood functions are proposed as a pragmatic approach to implicitly account for errors in measurements, model inputs and model structure and to avoid over-fitting to reference data [@BB92]. Definition of informal likelihood functions is problem specific in nature, and there has been no consensus on which informal likelihood functions outperforms others. For the sake of illustration, in §\[sec:result\], the exponential informal likelihood function is used for the numerical example (together with ). It reads: $$\begin{aligned} L(\bm{\theta}\|\bm{d}) = \exp\left(-\zeta \cdot \dfrac{\sum_{i=1}^{N_d} \left((d_i-f_i) - (\overline{\bm{d}}-\overline{\bm{f}})\right)^2} {\sum_{i=1}^{N_d} \left(d_i- \overline{\bm{d}}\right)^2}\right), \label{EXP} \tag{EXP}\end{aligned}$$ where $\overline{\bm{d}}$ is the mean of observations, $\overline{\bm{f}}$ is the mean of the outputs of forward model, and $\zeta$ is a scaling constant. For some other widely used informal likelihood functions, see [@SBT08]. Adaptive hierarchical sparse grid methods for construction of the surrogate PPDF -------------------------------------------------------------------------------- The central task of Bayesian inference is to estimate the posterior distribution $P(\bm{\theta}\|\bm{d})$. It is often difficult to draw samples from the PPDF directly, so the MCMC methods, such as the Metropolis-Hastings (M-H) algorithm [@GL06] and its variants, are normally used for the sampling process. In practice, the convergence of MCMC methods is often slow, leading to a large number of model simulations. To tackle this challenge, surrogate modeling approaches seek to build an approximation (called the surrogate system) for $P(\bm{\theta}\|\bm{d})$, then the MCMC algorithm draws samples from it directly without executing the forward model. With this approach, the main computational cost for evaluating the PPDF is now transferred to the surrogate construction step. Naturally, an approximation method which requires minimal number of grid points in the parameter space, while not surrendering much accuracy is desired. The methodology we utilize to construct the surrogate system, presented in this subsection, is similar to the method introduced in [@ZLY+13]. Since the method can be applied to functions governed by partial differential equations, not limited to $P(\bm{\theta}\|\bm{d})$ or $\bm{f}(\bm{\theta})$, a generic notation $\eta(\bm{\theta}):\Omega\to \mathbb{R}$ is used for the description. The following assumptions are needed: 1. The domain $\Omega$ is a rectangle, i.e., $\Omega = \Omega_1 \times \ldots \times \Omega_{N_\theta}, $ where $\Omega_n \subset \mathbb{R},\, n= 1,\ldots, N_\theta.$ 2. The joint probability density function ${ \rho}({\bm \theta})$ is of product-type: $$\begin{aligned} { \rho}({\bm \theta}) = \prod_{n=1}^{N_{\theta}} \rho_n(\theta_n),\end{aligned}$$ where $\rho_n:\Omega_n\to \mathbb{R}$ are univariate density functions. 3. The univariate domains and density functions are identical: $$\begin{aligned} \Omega_1 = \ldots = \Omega_{N_{ \theta}};\ \rho_1 = \ldots = \rho_{N_{ \theta}},\end{aligned}$$ yielding the same $i$-level univariate quadrature rules $$\begin{aligned} \mathcal{Q}_i^{(1)}[\cdot] = \ldots = \mathcal{Q}_i^{(N_\theta)}[\cdot] =: \mathcal{Q}_i[\cdot] . \end{aligned}$$ 4. The univariate quadrature rules are nested. ### Adaptive sparse grid interpolation {#s_1dhintp} The basis of constructing the sparse grid approximation in the multi-dimensional setting is the one-dimensional (1-D) hierarchical interpolation. Consider a function $\eta(\theta): [0,1] \rightarrow \mathbb{R}$. The 1-D hierarchical Lagrange interpolation formula is defined by $$\label{1d_hintp} \mathcal{U}_K[\eta](\theta) := \sum_{i=0}^K \Delta \mathcal{U}_i[\eta](\theta),$$
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10015, 326, 2692, 745, 616, 1211, 13, 2060, 34514, 15744, 15, 5815, 3558, 369, 2104, 281, 6351, 271, 2460, 273, 247, 8142, 10651, 15, 1893, 899, 8235, 13, 29489, 13, 285, 1023, 1368, 90, 328, 3395, 3210, 323, 247, 1133, 22738, 7138, 285, 24071, 17739, 13 ]	through inheritance. Story continues below advertisement It says the average inheritance received by the 50-75 age cohort over the past decade was $180,000. CIBC forecasts the average inheritance will be higher than that, due to the increased value of assets – particularly homes. "This significant wealth transfer could impact important economic variables such as wealth distribution, savings, labour market participation, start-up activity, and real estate markets," writes CIBC economist Benjamin Tal.Tips For How To Successfully Hire A Top It Employee Through A Recruitment Agency As per a recent report published by Jobvite, over 65% of companies claim talent shortage is their biggest challenge when hiring. This is especially true when it comes to specialized jobs in the IT (Information Technology) sector. If you are looking to recruit in this sector, partnering with a reliable recruitment agency is your best bet. – Access to a specialized network: Highly qualified candidates in the IT/technology niche are almost impossible to reach through traditional job boards or advertisements. However, staffing agencies have a wide reach in terms of network and they maintain an updated database of such hard-to-find professionals. Through their years of recruitment experience and personal connections, they can match you with the perfect candidate quickly. – Technical know-how: Your in-house HR department might not have the practical knowledge of the technologies, tools, and applications crucial for determining the right fit for a particlur, specialized IT job opening. Professional agencies work with experienced Tech Recruiters who are well-versed with coding languages, tech platforms, and advanced tools. Clearly, such recruiters can analyze an applicants technical prowess better and more successfully identify the ones most suited for your companys job requirement. – Maximum reach: In the IT sector, job changes can happen quickly. This is mainly because of the growing opportunities in this niche. Recruiters monitor new profiles regularly and can even reach out to candidates who are in what is called, the passive state. A passive candidate is open to new opportunities but not actively looking for a new job. They are unlikely to bother checking job boards and ads. Reaching out to such professionals can get you access to the best talent in the market, so you can find the right fit for a company’s IT needs. Specialist recruitment agencies can be a huge help with filling vacant positions in highly specialised fields. Click for more info. – Temporary or Full-time roles: Information technology is a dynamic field which is why many companies need IT experts on a consulting or temporary basis. This could be for a client-site requirement or development of a specific application for a larger project. Whatever your reason, finding skilled temp workers can be challenging. Working with a staffing firm allows you to find such profiles quickly. Agencies tend to have a dedicated database of technology experts who can help you with your project-based needs. – Access to market data: If you are looking for IT professionals, you need to understand that this is an increasingly talent-driven market and very competitive. Simply stated, if you are not offering competitive wages then you may miss out on having the brightest professionals work for you. Recruitment agencies have exclusive insights of the job market including salary benchmarks for every niche. They can help you determine the right remuneration for your scope of work, so you can get and retain the top talent. Employee recruitment is not just about filling a vacancy in your workplace but it’s also about finding candidates who have the right skills, can merge with your company culture and perform as per expectations. Partnering with recruitment experts can ease this stress for you and help you pick the best talent quickly and more cost-effectively.Detection of sporadic cases of Norovirus infection in hospitalized children in Italy. This study was performed to investigate the role of Noroviruses (NV) in sporadic cases of acute diarrhoea among hospitalized children in Brescia Hospital. NV were the most frequently involved viruses (23.7%) and were more common in children >5 years (23/63) than in children <5 years (6/59). The majority of the NV-positive specimens belonged to genotype II (GII). The frequency of rotavirus, enteric adenovirus and astrovirus was 12.2%, 1.6% and 2.4%, respectively. Results obtained confirm the relevance of NV as a causative agent of pediatric diarrhoea and highlight the need for continued surveillance of NV to prevent and control virus spreading.Voyaging in Strange Seas: The Great Revolution in Science In 1492 Columbus set out across the Atlantic; in 1776 American colonists declared their independence. Between these two events old authorities collapsed and a new, empirical worldview had arrived, focusing now on observation, experiment and mathematical reasoning. This book takes us along on a voyage of discovery that ushered in the modern age.The following is a true story, and this situation supposedly occurred in a real courtroom. At a trial, an attorney was putting witnesses through an exacting cross-examination, and was taking great delight into forcing witnesses to admit that they did not remember every single detail of an automobile accident. While the lawyer knew that no witness has a perfect memory, he had honed a skill in exploiting minor inconsistencies and lapses of memory in order to challenge the credibility of honest witnesses. After a series of scathing cross-examinations, he was looking forward to his examination of yet another witness. "Did you actually see the accident?" he asked. The witness responded with a polite, "Yes, sir." "How far away were you when the accident happened?" "I was Thirty-four feet, seven and three quarters inches away from the point of collision." "Thirty-four feet, seven and three quarter inches?" the lawyer asked, sarcastically, "Do you expect us to believe that your memory is so good, and your sense of distance is so precise, that months after the accident you can come into court and give that type of detail?" The witness was unphased. "Sir, I had a hunch that some obnoxious, know-it-all lawyer would ask me the distance, and would try to make it seem like I was lying if I could not give an exact answer. So I got a tape measure, and measured out the exact distance A man went to a brain store to get some brain to complete a study. He sees a sign remarking on the quality of professional brain offerred at this particular brain store. He begins to question the butcher about the cost of these brains. "How much does it cost for engineer brain?" "Three dollars an ounce." "How much does it cost for programmer brain?" "Four dollars an ounce." "How much for lawyer brain?" "$1,000 an ounce." "Why is lawyer brain so much more?" "Do you know how many lawyers we had to kill to get one ounce of brain?"Girls’ Generation’s stylist, Seo Sookyung, is renowned for her talent, even winning the Style Award at the 2012 Gaon Awards. She took part in an interview with MK Fashion, talking about her life, style, and working with Girls’ Generation. “It’s been exactly 10 years this year.” She became a student under stylist Han Hyeyeon when she was barely in her 20s. She said she felt like crying, walking along the streets where her first photoshoot, which she shot carrying around a pack of clothes larger than herself, was plastered in Myeongdong. And after 10 years, she has become an “executive director”, with six assistants. Also, the celebrity she fastens buttons for with her own hands is Girls’ Generation. “People usually work as an assistant for three to four years, or there are some who don’t go independent becoming an executive director, and become a team leader. Compared to others, I went independent really early. I was lucky.” The opportunity she had to go from a trainee to a stylist, making a full-fledged business card and making her name known, was while she worked on the advertising shoot for the makeup brand, “Etude”. At that time, the official model was being changed from Song Hyegyo to Go Ara, and that was when she got her chance. She showed off all the skills she learned through various brand advertisements to her heart’s content. Even after the model was changed to Park Shinye, she was in charge of the brand’s face for three years. “Good things happened all at once. Jung Hyeyoung, who I was in charge of at the time, was becoming known as a charity angel, causing advertisements to burst in. And Shinhye’s management requested that I become an exclusive stylist, and I worked with them since ‘You’re Beautiful’.” Without measuring it with anything else, the seven years of time she spent only looking towards her job replied to her with the most valuable “Girls’ Generation”. After meeting the girls in 2011 through “The Boys”, she showed off her characteristic bright and happy-feeling styling skills, showing off a vintage, painting-like teaser, resulting in her receiving attention every day. In particular, she also presented Girls’ Generation the “fashionista” look this year. She had the girls, who were the symbols of group outfits, wear vivid jerseys, denim, kitsch, custom jewelry, and other clothes that showed off their own, individual personalities freely. Each member was able to gain an image of a fashion icon. Sooyoung, Jessica, and Seohyun became models for a handbag brand and makeup brands,
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3347, 273, 253 ]	which I dare not send to Eichhof." Bernhard made an impatient gesture, but Lothar went on: "I know what you mean. You mean that I ought to think of the future, when our positions will be so different. I ought to consider that what is all right for the future possessor of Eichhof is supreme folly for a petty lieutenant. All true and just; but why the deuce, then, did our father put me in the same regiment with yourself? and why does every one expect exactly the same from the poor lieutenant as from the eldest son and heir? and why are people so infernally stupid as not to take into account the immense difference between us?" "It was certainly unfortunate," said Bernhard, "that you joined just this regiment; no doubt you are led here into many expenses that can hardly be avoided; but still----" "Well, then, I'd better go to friend Solomon to-morrow, and try my luck with him," Lothar interrupted him. Bernhard stamped his foot impatiently. "Don't talk nonsense!" he exclaimed. "Of course I shall help you out, since, as you justly remark, I may send in extra accounts when I please; but pray listen to reason, Lothar. You know that we shall shortly cease to live here together. When I marry I can no longer place my means at your disposal as at present." "Ah, when Thea is your wife, I shall quarter myself upon you so soon as my money is gone. It usually lasts until the twentieth of the month, and then I shall ensconce myself in your happy home. But I have not thanked you yet. Indeed, old fellow, you are a brick of a brother. Then I need not pay my respects to friend Solomon to-morrow?" Meanwhile they had reached their lodgings, and, as Bernhard was putting his key in the lock, he said, "I will help you through this time, Lothar, but remember it is the last. You must learn prudence, and it is in direct opposition to my principles to encourage this perpetual getting into debt. I did not, as you know, make the laws controlling inheritance, and I cannot alter the fact that our circumstances will be very different in the future. But I say now only just what I should say were you in my place and I in yours. Every man must cut his coat according to his cloth." "And if one is a six-footer and has only a scrap of cloth, he is in a desperate case," thought Lothar; but he kept his thought to himself, and softly whistled an opera air as he entered their apartments with his brother. "It's no end of a pity that we must leave our charming quarters so soon," he sighed, as he threw himself upon a lounge in their joint drawing-room, which was certainly most luxuriously fitted up for a bachelor establishment, while Bernhard opened and read, with a smile, a letter lying upon his table. Lothar watched him for a moment, then folded his arms and raised his eyes to the ceiling, with an expression half resignation and half disdain, while his thoughts ran somewhat thus: "Of course that is a letter from Thea. What under the sun can that little country girl have to say to him? A deuced pretty girl, and she'll make a capital wife. It's very odd that I'm not angry with her, for there's not another creature in the world so confoundedly in my way. If it were not for her, we should keep our comfortable lodgings, and Bernhard, who is certainly a trump, would go on paying my bills; and, besides, he has grown so infernally serious since he has had that little witch's betrothal-ring on his finger; before then we lived a jolly life enough. It is all Thea's fault,--his immense gravity, his ceasing to pay my debts, and our having to give up our delightful rooms. It is, therefore, Thea who prevents my enjoying my youth, as I should do otherwise, and yet, in spite of all this, I am rather fond of her. But it is not my nature to bear malice towards any woman, even although she be such an unformed little country girl as Thea, who certainly might have been content to wait a few years longer." "Bernhard," he suddenly said aloud, "I will withdraw to my inmost apartment, and leave you to your letter and to dreams of future petticoat rule." Bernhard put his letter in his pocket. "I have finished," he said, "and am going to bed. Thea sends her love to you." "Of course," yawned Lothar; "thanks. We'll talk about the other matter to-morrow?" "Yes. Good-night, Lothar." "Good-night, old fellow." CHAPTER II. TWO DISCONTENTED FATHERS. A forest bridle-path. The ground is covered with gnarled, twisted roots, and the way is bordered with dark pines, and firs somewhat lighter in tone, between which only a narrow strip of spring sky shines down upon the two riders pursuing the dim pathway. Their horses, slowly walking abreast, seem by no means content to saunter thus; the chestnut upon which the man is mounted champs its bit impatiently, and the gray by its side pricks its ears, but the girl upon the back of the latter is as interested as her companion in the conversation going on between them, and neither pays any heed to the signs of their steeds' impatience, while the groom riding at some distance behind them is enjoying a huge sandwich that he has produced from his pocket, in full security from observation. "It is too vexatious to know nothing about it all!" the girl exclaimed. "I am almost ashamed never to have been in Berlin." "But, good heavens, you are so young, Adela!" her companion rejoined. "If we are to continue friends, Walter, you will not begin again about my fifteen years, of which there can be no further mention after next month, when I shall be sixteen," was the irritated reply. "I am in reality much, much older, as you know, and I know that I look older. Only the other day Lieutenant Muellheim took me for eighteen; and if papa would only allow me to dress suitably, and if it were not for that stupid Almanach de Gotha that tells everybody our ages----!" She sighed pathetically. Walter laughed. "That sigh would sound more natural from the lips of a lady past her prime than from those of a budding girl in her teens," he said; adding instantly, with a meaning glance at his companion, "You must not look so angry with me, Adela dear. If you refuse to allow me more license in speaking than you accord to the rest of the world, I shall address you as Fraeulein von Hohenstein and think all our good-comradeship at an end. Must I do so? In fact, you certainly are too much of a great lady to be my 'good comrade' any longer." He spoke without irony, and there was a mournful earnestness in his fine eyes. She gave her horse a light cut with her whip, that his sudden start might give her the chance to conceal the bright blush that overspread her face. Then she looked up, half pouting, half in entreaty, and said, "If you want to tease me, Walter, I can't see why you came for me to ride; you might as well have stayed at home." Walter smiled, and saluted with his riding-whip. "Well, then, let us be good comrades for the future, as neighbors' children ought to be," he cried. Her reply was a merry glance from her blue eyes. They had reached the borders of the forest, and before them a well-kept road, bordered by fine old trees, led directly up to an imposing pile of buildings. "Let us have one more canter," said Adela; and away flew the two horses so suddenly that the groom behind them was, in his surprise, nearly choked by his last mouthful of sandwich, and followed his mistress coughing and gasping all the way up the avenue to the court-yard, where the two riders drew rein. "It has really grown so late that I cannot come in with you," said Walter. "I must hurry home; you know we are terribly punctual about our meals at Eichhof." "Well, then, good-by; for only a short time, I hope," said Adela, giving her comrade her hand, and then vanishing with the groom behind the court-yard gate, while Walter took the road to Eichhof. He was the third and youngest son of the
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1603, 85, 14, 84, 7415, 2249, 2461, 1743, 7873, 11326, 9, 67, 12, 18, 1933, 81, 14, 18, 16, 81, 32666, 19, 61, 1637, 889, 1274, 6087 ]	the proof of Theorem \[th-1.7\]. We can also establish the following assertion. \[th-4.3\] Assume that the heat kernel $p_t(\cdot,\cdot)$ satisfies [(A1)]{} and the measure $\mu$ satisfies (\[eq1.3\]). For $b>0$ and $T>0$, let $r_{0}=b\beta^{\star}/2\alpha$, $I=[0,T)$. Assume that $r\geq r_{0}>1$ and that $(q,p,r)$ is a generalized admissible triplet satisfying $p>b+1$. - If $f\in C_{q/(b+1)}(I; L^{p/(b+1)})$, then for $p<r(b+1)$, $$\\|G(f)\\|_{L^{\infty}(I; L^{r})}\leq T^{1-b\beta^{\star}/2r\alpha}\\|f\\|_{C_{q/(b+1)}(I; L^{p/(b+1)})}.$$ For $p\geq r(b+1)$ and $\theta=[p-r(b+1)]/(b+1)(p-r)$, $$\\|G(f)\\|_{L^{\infty}(I; L^{r})}\leq CT^{1-b\beta^{\star}/2r\alpha}\\|\|f\|^{1/(b+1)}\\|^{\theta(b+1)}_{L^{\infty}(I; L^{r})} \\|\|f\|^{1/(b+1)}\\|^{(1-\theta)(b+1)}_{C_{q}(I; L^{p})}.$$ - If $f\in C_{q/(b+1)}(I; L^{p/(b+1)})$, then for $p<r(b+1)$, $$\\|G(f)\\|_{C_{q}(I; L^{p})}\leq T^{1-b\beta^{\star}/2r\alpha}\\|f\\|_{C_{q/(b+1)}(I; L^{p/(b+1)})}.$$ For $p\geq r(b+1)$ and $\theta=[p-r(b+1)]/(b+1)(p-r)$, $$\\|G(f)\\|_{C_{q}(I; L^{p})}\lesssim T^{1-b\beta^{\star}/2r\alpha}\\|\|f\|^{1/(b+1)}\\|^{\theta(b+1)}_{L^{\infty}(I; L^{r})} \\|\|f\|^{1/(b+1)}\\|^{(1-\theta)(b+1)}_{C_{q}(I; L^{p})}.$$ \(i) For the case $p<r(b+1)$, we use Lemma \[le-4.1\] to derive $$\\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\\|_{L^{r}(\mathbb{M})}\lesssim (t-s)^{-\beta^{\star}[(b+1)/p-1/r]/2\alpha}\\|f(s,\cdot)\\|_{L^{p/(b+1)}(\mathbb{M})},$$ thereby getting $$\begin{aligned} &\\|G(f)\\|_{L^{\infty}(I; L^{r})}\\ &\ =\sup_{t\in[0,T)}\\|G(f)\\|_{L^{r}(\mathbb{M})}\\ &\ \leq\sup_{t\in[0,T)}\int^{t}_{0}\\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\\|_{L^{r}(\mathbb{M})}ds\\ &\ \lesssim \sup_{t\in[0,T)}\int^{t}_{0}(t-s)^{-\beta^{\star}[(b+1)/p-1/r]/2\alpha}\\|f(s,\cdot)\\|_{L^{p/(b+1)}(\mathbb{M})}ds\\ &\ \lesssim \\|f\\|_{C_{q/(b+1)}(I; L^{p/(b+1)})}\sup_{t\in[0,T)}\int^{t}_{0}(t-s)^{-\beta^{\star}[(b+1)/p-1/r]/2\alpha}s^{-(b+1)/q}ds\\ &\ \lesssim \\|f\\|_{C_{q/(b+1)}(I; L^{p/(b+1)})}\sup_{t\in[0,T)}t^{1-b\beta^{\star}/2\alpha r}\int^{1}_{0}\frac{u^{-(b+1)/q}}{(1-u)^{\beta^{\star}[(b+1)/p-1/r]}}du\\ &\ \lesssim T^{1-b\beta^{\star}/2\alpha r}\\|f\\|_{C_{q/(b+1)}(I; L^{p/(b+1)})}.\end{aligned}$$ Next we consider the case $p\geq r(b+1)$. Lemma \[le-4.1\] implies $$\\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\\|_{L^{r}(\mathbb{M})}\leq C\\|f(s,\cdot)\\|_{L^{r}(\mathbb{M})}.$$ If $$\begin{cases} &\theta\in (0,1);\\ &r(b+1)\theta p'=r;\\ &r(b+1)(1-\theta)q'=p;\\ &1/p'+1/q'=1, \end{cases}$$ then $$\theta=[p-r(b+1)]/(p-r),$$ and hence Hölder’s inequality is used to derive $$\begin{aligned} &\\|G(f)\\|_{L^{\infty}(I; L^{r})}\\ &\ \leq\sup_{t\in [0,T)}\int^{t}_{0}\\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\\|_{L^{r}(\mathbb{M})}ds\\ &\ \lesssim \sup_{t\in [0,T)}\int^{t}_{0}\\|f(s,\cdot)\\|_{L^{r}(\mathbb{M})}ds\\ &\ =\sup_{t\in [0,T)}\int^{t}_{0}\left\\|\|f(s,\cdot)\|^{1/(b+1)}\right\\|_{L^{r(b+1)}(\mathbb{M})}ds\\ &\ =\sup_{t\in [0,T)}\int^{t}_{0}\left\\|\|f(s,\cdot)\|^{1/(b+1)}\right\\|^{\theta(b+1)}_{L^{r}(\mathbb{M})}\left\\|\|f(s,\cdot)\|^{1/(b+1)}\right\\|^{(b+1)(1-\theta)}_{L^{p}(\mathbb{M})}ds\\ &\ \lesssim \left\\|\|f\|^{1/(b+1)}\right\\|^{\theta(b+1)}_{L^{\infty}(I; L^{r})}\left\\|\|f(s,\cdot)\|^{1/(b+1)}\right\\|^{(b+1)(1-\theta)}_{C_{q}(I;L^{p})}\\ &\ \ \ \times \Big(\sup_{t\in [0,T)}\int^{t}_{0}s^{-(b+1)(1-\theta)/q}ds\Big)\\ &\lesssim T^{1-\beta^{\star} b/2\alpha r}\left\\|\|f\|^{1/(b+1)}\right\\|^{\theta(b+1)}_{L^{\infty}(I; L^{r})}\left\\|\|f(s,\cdot)\|^{1/(b+1)}\right\\|^{(b+1)(1-\theta)}_{C_{q}(I;L^{p})}.\end{aligned}$$ Finally, we begin to prove (ii). Suppose $$f\in C_{q/(b+1)}(I; L^{p/(b+1)}).$$ For the case $p<r(b+1)$, we use Lemma \[le-4.1\] to obtain $$\left\\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\right\\|_{L^{p}(\mathbb{M})}\leq C(t-s)^{-\beta^{\star}[(b+1)/p-1/p]/2\alpha}\left\\|f(s,\cdot)\right\\|_{L^{p/(b+1)}(\mathbb{M})}.$$ Then a direct computation gives $$\begin{aligned} &\\|G(f)\\|_{C_{q}(I; L^{p})}\\ &\ :=\sup_{t\in [0,T)}t^{1/q}\\|G(f)\\|_{L^{p}(\mathbb{M})}\\ &\ \leq\sup_{t\in [0,T)}t^{1/q}\left\\|\int^{t}_{0}e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)ds\right\\|_{L^{p}(\mathbb{M})}\\ &\ \leq\sup_{t\in [0,T)}t^{1/q}\int^{t}_{0}\left\\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\right\\|_{L^{p}(\mathbb{M})}ds\\ &\ \leq\sup_{t\in [0,T)}t^{1/q}\int^{t}_{0}(t-s)^{-\beta^{\star}[(b+1)/p-1/p]/2\alpha}\left\\|
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So, needless to say, she has an impressive resume and a passion for understanding pelvic pain. Just check out her wrap sheet. I’ve chosen a few interesting nuggets from her lecture. Each of these camps have their own combination of modifiers that can lead to sensitization. Pause- so this is where one can get overloaded with information, so I took some creative liberties and decided to draw a picture. As you see from the drawing, there are several areas where our brain and our body can modify signals related to pain. At the “nociceptor sensitization camp” the sensory nerves can become extra excited, and maybe throw too much input into the nervous system. For example, do you remember the last sunburn you had? Remember how sensitive your skin was- even the slightest touch was immensely painful. Well, now imagine that you don’t have a sunburn but your nerves are sending that same intense signal, as if your tissue was still burned. This nervous system mix up is called allodynia, when normally non-painful stimulus is extremely painful. At the “stream of spinal central sensitization” the spinal cord can send information upstream, to the brain, or downstream, to the peripheral nerve, to modify signals related to pain. For example, #1 on the list, prolonged dorsal horn firing, is similar to an echo. This is when your hand-nerve yells “watch out” to your spinal cord, and your spinal cord yells to your brain “watch out….watch out….watch out….watch out….watch out… watch out…watch out….” well you get the idea. A single signal potentiates into multiple. Finally we have the “lake of cortical reorganization”, or in layman’s terms, brain change. Here you can have tidepools of emotional distress or reefs of prior history or insert another water-based metaphor here. Essentially, upcoming signals are then interpreted within the framework of the brain where it decides if it’s enough to produce a pain response. How this all works is a bit murky, pardon the pun, but we do know that our interpretation of nociceptive signals greatly impacts how the brain choose to deal with them. Somatic vs. Visceral: Crosstalk Dr. Farmer also touched on the differences between somatic and visceral pain and the crosstalk that can occur between the two. When comparing sensations from somatic (aka your body) and visceral structures (aka your organs), there are several differences. Somatic pain has a distinct quality, like a sharp or pinching sensation. It correlates specifically to the intensity, duration and location of the stimulus and is caused by tissue injury and inflammation. One easy example of somatic pain is the ankle pain one might experience following a sprain. Conversely, visceral pain is diffuse in quality and generally is found along the midline of the body. It doesn’t have the same on/off switch and tends to correlate very poorly with its stimulus. Just think how you felt the last time you had food poisoning…yah not fun. Okay, that seems reasonable, now we have some ways to separate out different types of pain. However, sometimes messages can get muddled when somatic and visceral structures start to talk to one another – called crosstalk. This can happen when sensory fibers of pelvic organs synapse close by where other somatic or visceral structures synapse at the spinal cord. You can see how it can get confusing when a problem in one organ might feel like a problem in a completely separate organ or body part. One case of this is viscero-somatic pain, when a visceral structure creates body pain. A well-known example of viscero-somatic pain is when during a heart attack someone might report significant left arm pain. In the pelvis however, this would look like a patient complaining of low back pain when the stimulus is actually coming from uterine contractions. This crosstalk can also go the opposite direction, somato-visceral pain. This could happen with vulvar inflammation. A patient may have multiple yeast infections leading to inflammation of the vulva (somato-), but then also experience bladder pain (visceral). And it doesn’t stop there. Viscero-visceral pain, yup that happens. Stimulus from one organ can be confused with stimulus from another organ. This can even lead to changes in how the organs function. This type of viscero-visceral pain is one explanation for the high prevalence of irritable bowel syndrome in women with endometriosis. What does this mean for patients? So now what? All of this can be quite overwhelming. It’s important for both patient and practitioners to educate themselves regarding the different facets of pain. Great resources including Dr. Farmer’s research and books like Explain Pain or Pelvic Pain Explained can be very helpful in help navigating these uncertain waters. Since knowledge is power, the more we understand the cause, the better we can treat pain together. Thank you again for the enlightening presentation Dr. Farmer! If you want to check out the whole presentation, which we recommend, look here.Tri City Rentals Partners with American Red Cross and the City of Albany to Support Swim Program! 7/21/2014 10:06:16 AM On Wednesday, July 9th, 2014 Tri City Rentals, American Red Cross Northeastern New York, and the City of Albany partnered together to kick off this year’s Learn-to-Swim Program at Lincoln Park Pool in Albany, NY.University community turns out to share feedback on draft strategic plan Khaled Keshk, associate professor and chair of Religious Studies, comments during a town hall meeting to discuss a draft of the university's strategic plan. (DePaul University/Jeff Carrion) Two town hall meetings soliciting feedback on the draft strategic plan attracted standing room only crowds, demonstrating the investment faculty, staff and students are making in envisioning DePaul's future. Forum participants affirmed the Board of Trustees' call to give mission strategies their own goal, arguing mission is what distinguishes DePaul and should be seen as what informs all other goals. Requests also were made to elaborate on how DePaul's Catholic and Vincentian identity should be further institutionalized as the number of religious Vincentians available to reinforce that identity diminishes. "The university has discussed catholic with a small c - meaning universal, open and inclusive - but Catholic with a capital C does not mean the opposite," says Mark Laboe, associate vice president for Mission and Ministry. "We have to be more clear about what we mean by Catholic." The intrinsic value of the liberal arts and the organization of technology services to accomplish the university's business and enhance academic programs and student services were among the top topics of conversation. Meanwhile, comments about the student experience were wide-ranging. Several people noted that students suffer by being "bounced around" when there is a lack of knowledge about what individual departments do or poor communication between units. Ensuring appropriate student support services in new programs was another concern. There was a request for more evening and weekend courses for undergraduates and non-traditional students, such as working parents, who cannot take daytime classes. Although online enrollment is growing fast, the university was cautioned about offering certain classes and programs exclusively online because students using veteran benefits cannot be reimbursed for expenses related to online offerings. Jay Braatz, vice president for strategic planning and presidential administration, chairs the representative Strategic Planning Task Force that assembled the draft plan. She noted that it is the board's responsibility to establish the university's strategic direction based on conditions prevailing in the higher education landscape. She also noted that the board does not do its work in a vacuum, but relies on the wisdom and input of the university community. "Once strategic direction is set," she says. "It is the job of the university community to implement the plan. It will be up to us to determine what steps we need to take to reach the plan's goals and objectives." Several applauded the inclusion of an objective to develop students' global citizenry, one participant noting the importance of speaking another language "as a pre-requisite for true cultural agility," and another indicating that religious competency is a critical skill to navigate many cultures around the world. Diversity strategies attracted comments that touched many corners of the university, from the necessity of people in positions of privilege to become more inclusive of historically marginalized communities to ensuring that an increase in diversity among employees should include hiring in positions of power. A number of staff members said they felt the role professional staff needed to be articulated more forcefully, particularly since staff will have a major role in achieving the proposed goals. Faculty requested acknowledgement of the increase in contingent faculty and the roles that different types of faculty play. A summary of themes from the town halls can be found here. "Many times, what the church teaches and believes comes from the ground up. They were practicing it and living it, and it was part of their reality. Then it became formalized in the church structure," he noted in closing the session. "My sense is that you are living the Catholic, Vincentian mission. You are part of this university, and from your experience will come a strategic plan that we can look at and say 'that is who we are' because that's what we are doing."Course Description: In this course, practical experience in solo and ensemble instrumental performance is offered. The required performance level for entry into this course is left to the discretion of the instructor. This course is the second of the sequence: MUS 153, MUS 154, MUS 253, and MUS 254. Course Goals: Upon successful completion of this course, students should be able to do
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Small Material Vibrator Feeder, Wholesale Various High Quality Small Material Vibrator Feeder Products from Global Small Material Vibrator Feeder Suppliers and Small Material Vibrator Feeder Factory,Importer,Exporter at .-- +migrate Up ALTER TABLE hydra_client ADD frontchannel_logout_uri TEXT NULL; ALTER TABLE hydra_client ADD frontchannel_logout_session_required BOOL NOT NULL DEFAULT FALSE; ALTER TABLE hydra_client ADD post_logout_redirect_uris TEXT NULL; ALTER TABLE hydra_client ADD backchannel_logout_uri TEXT NULL; ALTER TABLE hydra_client ADD backchannel_logout_session_required BOOL NOT NULL DEFAULT FALSE; UPDATE hydra_client SET frontchannel_logout_uri='',post_logout_redirect_uris='',backchannel_logout_uri=''; ALTER TABLE hydra_client MODIFY frontchannel_logout_uri TEXT NOT NULL; ALTER TABLE hydra_client MODIFY post_logout_redirect_uris TEXT NOT NULL; ALTER TABLE hydra_client MODIFY backchannel_logout_uri TEXT NOT NULL; -- +migrate Down ALTER TABLE hydra_client DROP COLUMN frontchannel_logout_uri; ALTER TABLE hydra_client DROP COLUMN frontchannel_logout_session_required; ALTER TABLE hydra_client DROP COLUMN post_logout_redirect_uris; ALTER TABLE hydra_client DROP COLUMN backchannel_logout_uri; ALTER TABLE hydra_client DROP COLUMN backchannel_logout_session_required; THIS IS NASA'S RESPONSE TO ANONYMOUS' ALIEN DISCLOSURE CLAIM When the online collectivist group Anonymous released a new video this week claiming that the space agency NASA was imminently about to announce the discovery of extra-terrestrial life in this universe, it generated a huge amount of excitement for space watchers all over the world. Unfortunately, according to the space agency, the claims made by Anonymous in this viral video is simply incorrect. NASA CLAIMS THAT ANONYMOUS’S ALIEN ANNOUNCEMENT VIDEO IS FALSE "Contrary to some reports, there's no pending announcement from NASA regarding extraterrestrial life, "said Robert Zurbuchen, NASA associate administrator for science in a tweet published this week, putting an end to the speculation that the space agency was on the cusp of making a major announcement about the discovery of extra-terrestrial life. “Control oil and you control nations; control food and you control the people.”Henry Kissinger “once a standing army is established, in any country, the people lose their liberty.”George Mason “Military men are dumb, stupid animals to be used as pawns for foreign policy.”Henry Kissinger “If you are an ordinary person, then you can prepare yourself for war by moving to the countryside and building a farm, but you must take guns with you, as the hordes of starving will be roaming. Also, even though the elite will have their safe havens and specialist shelters, they must be just as careful during the war as the ordinary civilians, because their shelters can still be compromised.”Henry Kissinger "We don't let them have ideas. Why would we let them have guns?" Joseph Stalin The people who cast the votes decide nothing. The people who count the votes decide everything.Joseph Stalin Governments keep a lot of secrets from their people . . .Why aren't the people in return allowed to keep secretsfrom the government?PHILIP ZIMMERMAN, DER SPIEGEL“Some call it Communism, I call it Judaism.” Rabbi Stephen Weiss “Anti-Communism is Anti-Semitism.” Jewish Voice, July - August 1941 Taxing People is Punishing SuccessUNKNOWN There's the rich, the poor, and the tax payers...also known as the middle class.Robert Kiyosaki ‏ The Tax you pay is The Bill for Staying StupidStefan Molyneux “The modern banking system manufactures money out of nothing. The process is, perhaps, the most astounding piece of sleight of hand that was ever invented. Banks can in fact inflate, mint and un-mint the modern ledger-entry currency.” Major L L B Angus The few who understand the system will either be so interested in its profits or so dependent on its favours that there will be no opposition from that class, while on the other hand, the great body of the people mentally incapable of comprehending the tremendous advantage that capital derives from the system will bear its burdens without complaint and perhaps without even suspecting that the system is inimical to their interests.The Rothschild Bros "Debts must be collected, bonds and mortgages must be foreclosed as rapidly as possible. When, through a process of law, the common people lose their homes they will become more docile and more easily governed through the influence of the strong arm of government, applied by a central power of wealth under control of leading financiers. This truth is well known among our principal men now engaged in forming an imperialism of Capital to govern the world. By dividing the voters through the political party system, we can get them to expend their energies in fighting over questions of no importance. Thus by discreet action we can secure for ourselves what has been so well planned and so successfully accomplished." USA Banker's Magazine, August 25 1924 Cutting Tax Rates stimulates Economic Growth creates more Profit , more Jobs and therefore The Treasury ends up with more Tax Money UNKNOWN Taxation is legalized Theft UNKNOWN "The Objective of the Bank is not the control of a conflict , it's the control of the debt that a conflict produces . The real value of a conflict , the true value is in the debt that it creates . You control the debt , you control everything . this is THE VERY ESSENCE OF THE BANKING INDUSTRY , to make us all , whether we be nations or individuals , SLAVES TO DEBT " An UNKNOWN Banker Patriotism is the last refuge... to which the scoundrel clings .... Steal a little and they throw you in jail ..steal a lot and they make you king .... Bob Dylan "Corporations are stealing billions in tax breaks, while the confused, screwed citizenry turn on each other. International corporations have no national allegiance, they care only for profit." Robert Reich There is NO political answer to a spiritual problem!Steve Quayle Political Correctness is a Political Stand Point that does not allow Political Opposition , This is actually The Definition of Dictatorship Gilad Atzmon The modern definition of racist is someone who is winning an argument with a liberalPeter Brimelow When People lose everything and have nothing left to lose , They Lose It ! GERALD CELENTE Your Greatest Teacher is Your Last Mistake DAVID ICKE The one who Controls the Education System , Controls PerceptionUNKNOWN "The world will not be destroyed by those who do evil, but by those who watch them without doing anything." Albert Einstein Receive These Posts by Email: Search This Blog Let me tell you why you're here. You're here because you know something. What you know you can't explain, but you feel it. You've felt it your entire life, that there's something wrong with the world. You don't know what it is, but it's there, like a splinter in your mind, driving you mad. It is this feeling that has brought you to me. Do you know what I'm talking about? Morpheus The Matrix 1999 No man escapes when freedom fails; The best men rot in filthy jails. And those that cried 'Appease! Appease!' Are hanged by those they tried to pleaseUNKNOWN Freedom is not FreeUNKNOWN Don't Steal The Government Hates The CompetitionRon Paul "Buy The Rumor , Sell The Fact "Peter Schiff You can love your Country and not your Government Jesse Ventura " The Government Works for ME , I do not answer to them They Answer to ME "Glenn Beck "Tyranny will Come to Your Door in a Uniform "Alex Jones "The Government is not The Solution to our Problems , The Government is The Problem "Ronald Reagan "The price good men pay for indifference to public affairs is to be ruled by evil men."Plato The world is a tragedy to those that feel, and a comedy to those that think...Beppe Grillo "The people should not fear the government for it is the government who should fear the people"UNKNOWN "If You are looking for solutions to the world's problems , look in the Mirror , You Are The Solution , You have the power as a human being on this planet " UNKNOWN "They don't control us , We empower them " UNKNOWN "Serial Killers do on a Small Scale What Governments do on a large one..." Serial Killer Richard Ramirez There is a Class War going on in America, & unfortunately, my class is winning."Warren Buffet
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Hanshaw says she feels both she and her dead son have been unjustly vilified in the press over the last few days. For the first time during our chat, there is an edge of anger in her voice. "I know people are blaming me and I know people are blaming him, but what I say is – you don't know me, and you didn't know my son. I did my best for him, just like any other mother. Yes, his dad and I split up, but we're still friends, he's been down here this week. It wasn't the worst break-up." One of the things that has hurt her most has been that some people have said that it was right that her son wasn't deemed eligible for the liver transplant that might have saved his life. "I've heard people have said that reading about Gal makes them feel like ripping up their donor cards. Well, rip them up! We wouldn't want a liver from anyone like them anyway." She pauses. "At the end of the day, I'm just a mum who was trying to keep her child alive. You'd do anything … I'd do anything …" She had heard that a transplant would have given Gary a 75% chance of recovery. She did all she could for him in what turned out to be his final weeks. "I was at the hospital every day." Now, she says, she'd just like other mothers, and other young people like Gary, to know the reality of heavy drinking. "If they could have seen my Gary lying there, so ill and so swollen … if they could have heard how much he wanted to live. If I'd known then what I know now I'd have done something, anything, to stop him drinking but I didn't know it could turn out this bad. And I didn't know how to stop it." How to stop young alcoholism is the $64,000 question: and according to Sheron the answer, like the problem, is multifactorial. "There isn't one single reason for it, and there isn't one single solution to it," he says. One thing he will be pinned down on is cheap alcohol marketed directly at young people. "We've got to look at the fact that there are almost no controls on this," he says. "It's being pushed through the internet, through mobile phones, through all channels." But for Gary Reinbach, there was to be no second chance. "I'm not saying he was the perfect son," says his mother. "But I'll tell you this: he didn't deserve to die like that, at 22. No one does. And I hope to goodness others learn from it, because I don't want any other mother to go through what I'm going through."Rocky Cut Me, Mick Tee Rocky is in the 15th and final round of his brutal heavyweight championship bout against Apollo Creed. Rocky can't see nuthin'. He tells his trainer, Mickey, "You gotta open my eye". Open your eye in this ring-spun slub jersey. Contenders don't quit!Q: Qt Installer кириллица в пути Сделал инсталятор с Qt Installer, вроде бы всё нормально, но в пути для каталога установки, если попадается кириллица - выводится ошибка. Для меня понятна, а пользователей ввергает в иррациональный ужас и панику, так как пишет, что мол найден символ не относящийся к ANCII, выберите другую папку. Нельзя ли убрать это ограничение или хотя бы изменить текст этой ошибки. A: Простите дурака, не заметил сразу в документации. В одном из примеров сейчас наткнулся на такую строчку в конфиге. <AllowNonAsciiCharacters>true</AllowNonAsciiCharacters> Vicar prays for end to St Thomas’ Church Hall saga HOPING: The Rev Stephen Grey at St Thomas' Church Hall A vicar is praying for an end to a planning wrangle which has held up the creation of a new community hall for at least two years. The Rev Stephen Grey is hoping Wyre planning committee will finally grant full planning permission for St Thomas’ Church Hall to be revamped into four homes, together with the creation of another home on the car park. Once permission is granted, the site, on Church Street, Garstang, can be sold to developers, and the cash can be used to finish the shell of a new church hall down the road in the vicarage garden. “This has been going on for years,” said Rev Grey. “One of the problems has been that there are various parties involved. We want to keep the facade of the hall, and the other plot earmarked for a house would be left for use as a car park. “I understand the full planning application will be considered on March 6 by the planning committee,” said Rev Grey. “I really hope this will be the end of it, and that we can move on and create a new community hall for use by people in Garstang. “The old hall has served the community as school and hall since 1845 and we wish to continue that service with the new. We already have organisations queueing to use it. There has been massive support from local people, with more than 50 letters of support, and I would like to say a big thank you.”Frat raises over $5K in fundraising Hang on for a minute...we're trying to find some more stories you might like. Email This Story Send email to this addressEnter Your NameAdd a comment hereVerification The recent loss of a fraternity brother inspired an idea for Sigma Phi Epsilon, to focus their fall philanthropy event on epilepsy awareness. Epilepsy awareness lasted a full week; SigEp surpassed their goal of raising $3,000 in the first night. Totaling to over $5,000, SigEp raised more than they ever have toward their philanthropy, said junior nursing major and SigEp president, Billy Enderle. Ryan Hall, senior electronic media and broadcasting major and community service and philanthropy chair for the fraternity, headed epilepsy awareness week. The bombshell of the week was the date auction on Oct. 1. “I said we’d be lucky to make $1,000,” Enderle said. “We beat that within the first ten guys which was exciting.” The date auction featured about 30 members of SigEp who were auctioned off based on the credentials they had set for a date to take one woman on. “We didn’t know how well it would work, we were just kind of testing the waters,” Enderle said. “It was surreal. It took a lot of stress off of the remainder of the week,” he said. Hall explained the date auction brought him to tears. “Eric Schuler and I were emceeing the event and I stepped off stage to check the tally of how much we had raised so far, someone stopped me and said, ‘Ryan, we have raised $1,500,’ I teared up and had to get back on stage after that,” he said. Enderle said this event was a real “morale booster” with Chaz Edwards and Holdan Markland being names to mention in terms of bids received. Edwards went up on stage last but he was not least, receiving the highest bid of the night at $370. “I was in shock the bid ending up being that much,” Edwards said. “I didn’t know what to expect at first, I went in flying blind.” Edwards was bought by the women of Phi Sigma Sigma as a chapter. Edwards admitted that unlike the majority of the guys who had planned dates like picnics and taking a woman out to the dinner of her choice, he didn’t have much of a plan going up on stage. His finale on stage was removing his shirt. Other events throughout the week included a Dine to Donate at Applebee’s Sept. 30-Oct. 7, two-week long penny wars, a dodgeball tournament with Theta Phi Alpha, the opportunity to paint a SigEp purple and a vigil. The vigil was held on the Griffin Hall lawn and was held mostly for those who knew Evan Draper, but all those who are affected by epilepsy in some form were invited. Cathy Schragg with the Epilepsy Foundation of Greater Cincinnati played an imperative role throughout epilepsy awareness week, Hall expressed. He said she was very supportive, providing the fraternity with resources to help with fundraising, including purple bracelets that read, “seize hope.” According to the foundation, “Epilepsy is a medical condition that produces seizures affecting a variety of mental and physical functions. When a person has two or more unprovoked seizures, they are considered to have epilepsy.” Draper had been coping with his condition since mid-high school, Hall said. The NKU chapter of Sig Ep hopes to adopt this as their philanth
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The error bars show the standard deviation of these mean values (only 80 values are here presented in order to enhance graphical clearness).](JBP2012-642745.002){#fig2} ![Histogram representation of the mechanical work, both for the system in presence (black bars) and absence (red bars) of the HSA complex. The continuous lines are the Gaussian distributions for the corresponding values of standard deviation and mean value for each histogram population.](JBP2012-642745.003){#fig3} ###### Charge distribution used for every atom in the construction of the Aspirin and Myristic Acid topologies, respectively. ###### \(a\) ------------------------------------------------------ Atom\ Atom\ Name Charge\ Partial\ Mass number Type group Charge -------- ------- ------ --------- ---------- --------- 1 OM OL 1 −0.635 15.9994 2 C CK 1 0.27 12.011 3 OM OM 1 −0.635 15.9994 4 C CJ 2 0 12.011 5 CR1 CI 2 0 13.019 6 CR1 CH 2 0 13.019 7 CR1 CG 3 0 13.019 8 CR1 CF 3 0 13.019 9 C CE 3 0 12.011 10 OA OD 4 0 15.9994 11 C CB 4 0.38 12.011 12 O OC 4 −0.38 15.9994 13 CH3 CA 5 0 15.035 ------------------------------------------------------ ###### \(b\) ------------------------------------------------------ Atom\ Atom\ Name Charge\ Partial\ Mass number Type group Charge -------- ------- ------ --------- ---------- --------- 1 OM OB 1 −0.635 15.9994 2 C CA 1 0.27 12.011 3 OM OC 1 −0.635 15.9994 4 CH2 CD 2 0 14.027 5 CH2 CE 2 0 14.027 6 CH2 CF 2 0 14.027 7 CH2 CG 2 0 14.027 8 CH2 CH 2 0 14.027 9 CH2 CI 2 0 14.027 10 CH2 CJ 2 0 14.027 11 CH2 CK 2 0 14.027 12 CH2 CL 2 0 14.027 13 CH2 CM 2 0 14.027 14 CH2 CN 2 0 14.027 15 CH2 CO 2 0 14.027 16 CH3 CP 2 0 15.035 ------------------------------------------------------ [^1]: Academic Editor: Claudio M. Soares Assessment of trace elements levels in patients with Type 2 diabetes using multivariate statistical analysis. The trace elements metabolism has been reported to possess specific roles in the pathogenesis and progress of diabetes mellitus. Due to the continuous increase in the population of patients with Type 2 diabetes (T2D), this study aims to assess the levels and inter-relationships of fast blood glucose (FBG) and serum trace elements in Type 2 diabetic patients. This study was conducted on 40 Egyptian Type 2 diabetic patients and 36 healthy volunteers (Hospital of Tanta University, Tanta, Egypt). The blood serum was digested and then used to determine the levels of 24 trace elements using an inductive coupled plasma mass spectroscopy (ICP-MS). Multivariate statistical analysis depended on correlation coefficient, cluster analysis (CA) and principal component analysis (PCA), were used to analysis the data. The results exhibited significant changes in FBG and eight of trace elements, Zn, Cu, Se, Fe, Mn, Cr, Mg, and As, levels in the blood serum of Type 2 diabetic patients relative to those of healthy controls. The statistical analyses using multivariate statistical techniques were obvious in the reduction of the experimental variables, and grouping the trace elements in patients into three clusters. The application of PCA revealed a distinct difference in associations of trace elements and their clustering patterns in control and patients group in particular for Mg, Fe, Cu, and Zn that appeared to be the most crucial factors which related with Type 2 diabetes. Therefore, on the basis of this study, the contributors of trace elements content in Type 2 diabetic patients can be determine and specify with correlation relationship and multivariate statistical analysis, which confirm that the alteration of some essential trace metals may play a role in the development of diabetes mellitus.Q: How to analyse LINQ queries I swear I've seen how to do this before, but now that I actually need to do it I can't remember where I saw it at. I need two different things -- 1) to see the actual SQL query that is generated by a LINQ query and 2) when the SQL query actually hits the database to do whatever (CRUD operations) Is there a tool that will allow me to do this? EDIT: Sorry, should have given more detail. -- LINQ to Entities is what I'm using. -- Also, I don't have admin rights on our instance of SQL Server, so I can't use SQL Profiler. I could always call the DBA and have them do it for me, but it's a hassle. I should have mentioned that and I apologize. What I really want is a tool that I can use on my own box that will allow me to see when a LINQ query hits the database while I am in debug mode (debugging and stepping through the code). A: Try using SQL Profiler. It's great for seeing what LINQ to SQL is generating. SQL Profiler is a graphical tool that allows system administrators to monitor events in an instance of Microsoft® SQL Server™. You can capture and save data about each event to a file or SQL Server table to analyze later. For example, you can monitor a production environment to see which stored procedures are hampering performance by executing too slowly. LINQPad is also a great tool for writing linq and sql statements for testing. LINQPad compiles your queries using .NET's CSharpCodeProvider (or VBCodeProvider). Because C# and VB are statically typed, any database objects that you reference need the backing of a typed DataContext. For performance, LINQPad builds typed DataContexts on the fly using Reflection.Emit rather than generating and compiling source code. It uses LINQ to SQL rather than Entity Framework because LINQ to SQL is an order of magnitude faster in building the metamodel when instantiated. A: The .ToString() on the IQueryable for LINQ to SQL will show you the query. var myquery = from x in dbcontext.MyTable where x.Prop1 == someValue select new { value1 = x.prop1, value2 = 5, }; var sqlstring = myquery.ToString(); //<= look in this string Opiate withdrawal during development: are NMDA receptors indispensable? Despite decades of research, the mechanisms that underlie opiate tolerance, dependence and withdrawal remain elusive. Evidence accumulated over the past ten years suggests that the NMDA receptor plays a central role in mediating the neuroplasticity induced by chronic opiate administration in adult animals. Yet, during ontogeny, the NMDA receptor complex undergoes qualitative developmental changes, which renders some of the basic assumptions for a role of the NMDA receptor in opiate withdrawal invalid in infants. Recent data indicate that NMDA receptor antagonists are not effective in blocking morphine tolerance, dependence and withdrawal in the neonatal rat. Roles for other glutamate receptor types (e.g. metabotropic glutamate receptors) have also been proposed recently. In this article, the latest evidence that characterizes the dynamic roles of glutamate receptors in these phenomena during ontogeny will be discussed.Hanger Hill Wood Hanger Hill Wood is a small remnant of ancient woodland to the east of the Hanger Hill Park and North Circular Road at Hanger Lane, in Ealing in the London Borough of Ealing. Named from 'Hangra', the Old English word for wooded slope. There is access from Hanger Lane (at pedestrian crossing by Hillcrest Road), alternative access is at several points on Chatsworth Road. Wildlife This site contains a variety of woodland native plants including Pedunculate oaks (Quercus robur), European beech (Fagus sylvatica), European yew (Taxus baccata), European holly (Ilex aquifolium), European ivy (Hedera helix) and other tree species. Breeding birds include common wood pigeons (Columba palumbus), common blackbirds (Turdus merula), Eurasian blue tits (Cyanistes caeruleus), common starlings (Sturnus vulgaris) and invasive rose-ringed
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2312, 281, 731, 15, 5729, 6881, 547, 671, 2550, 320, 187, 585, 1261, 850, 13, 390, 359, 2779, 7081, 4812, 45611, 359, 1364, 2454, 604, 359, 187, 609, 281, 320 ]	www.kff.org/slideshow/public-opinion-on-single-payer- national-health-plans-and-expanding-access-to-medicare-coverage/) [2] [https://www.pewresearch.org/science/2019/11/25/u-s-public- vi...](https://www.pewresearch.org/science/2019/11/25/u-s-public-views-on- climate-and-energy/) ------ ycombonator Case in point. CNN segment mocking working class people. [https://twitter.com/DailyCaller/status/1221999373829144578](https://twitter.com/DailyCaller/status/1221999373829144578) ------ woodandsteel Conservatives are split about the changes the article discribes. Traditional conservatives are glad the labor movement was destroyed, and see the Knowledge Economy as good because it is the latest product of the unrestrained free market. On the other hand, Trump supporters are very angry, but the problem is that Trump's program won't do anything at all to fix the problems that are making them unhappy. ~~~ DebtDeflation > Trump supporters are very angry, but the problem is that Trump's program > won't do anything at all to fix the problems that are making them unhappy. There's no way around the fact that more education (doesn't necessarily mean college) and greater labor force mobility (providing people with the ability to move where the jobs are) has to be a significant part of the solution. Stating the facts is not condescension, but I guess it can and does cause politicians to lose elections. ------ realtalk_sp I read this and can't help but think that the real fools are the ones buying into the elitism narrative that the far-right has been peddling for years. It's a deliberate red herring exploiting the very human tendency to chafe at any perceived condescension. If people in the US primarily voted the issues (that matter and affect them) instead of on the basis of nonsense, Democrats would win by a landslide. Republican politicians are trading away relatively meaningless concessions (on things they likely don't genuinely care about like guns, LGBT rights, abortion, religion, etc) as a cover for tremendously detrimental policymaking that includes broad spectrum deregulation, huge transfers into the military- industrial complex, and massive cuts to social programs including education, healthcare, welfare, etc. We know that's the game plan. The real fools are the people who continue to fall for this shit. Edit: I should add that I don't necessarily believe everything about the Democratic Party's platform is valid. But they are unquestionably the better choice for the vast majority of voters. ~~~ Consultant32452 I don't understand this predilection for believing that other people can't have genuinely held beliefs and values that are vastly different from our own. I hope we can one day come to understand that it's complete lunacy for Mobile Alabama to force Los Angeles to live by its cultural values or vice versa. But today is apparently not that day. ~~~ realtalk_sp I never argued that the people themselves don't genuinely hold different beliefs about gun rights, abortion, religion, LGBT, etc. I meant two things: 1. in terms of their effect on peoples' lives, these issues pale in comparison to certain other ones AND 2. Republican politicians are using these highly emotionally-charged social issues to induce people to vote against their own interests on dimensions of governance that would meaningfully impact their quality of life. ~~~ Consultant32452 What makes you think you have any insight into what is in their best interest, which of their interests should be most important to them, or how they should measure their quality of life? ~~~ realtalk_sp If you don't have cost-effective access to good healthcare, you could literally die. And if you're poorly educated, you're much more likely to be less financially well off and that could itself lead to all kinds of suffering. But I get the sense that you're aiming for the presentation of being objectively insightful when really you're quite transparently arguing in bad faith for the sake of provocation, so I'll just leave it at that. ~~~ mixmastamyk The democrats didn’t deliver cost-effective healthcare or education or anything they keep trying to subsidize. Prices keep going up. Funny how that works. The smugness is just icing on the cake. ~~~ Consultant32452 I don't think these details about specific policy outcomes is where the battle is. Look at the way he's responding. This isn't about whether your ideas have better outcomes than my ideas. This is about ascribing you with bad motives, disingenuousness, or portraying you as a simpleton who can't understand political manipulation. This is about controlling you, putting you in the bad/stupid box so you can be dismissed and controlled. Their tactic is to call you stupid, liar, racist, sexist... You know the list. If you argue on their terms, if you start arguing you're not stupid for example, you're accepting their framing. This is a losing battle. Instead I find it's more effective to simply draw attention to their tactic. Once the tactic is revealed it loses efficacy. If I genuinely believe you to be stupid, evil, disingenuous, etc. I won't be able to genuinely hear you. You're just making noise. I would encourage you to try this experiment out some time. Instead of arguing specific policy, point out the tactic. It's repeatable and quite telling. ------ lngnmn1 Education (and inflated government) is a new way of signaling a higher social state, similar to scholastic priesthood of the past. It is entirely a social construct (aside from practical, concrete-math-based STEM and engineering). Another real-life aspect is that passing through a really decent schools like MIT or Caltech (or Yale, as an exception) is a proof (by example) that one is capable of self-discipline, concentration, self-improvement, able to do research and learn on by doing. Aside from that a degree is just and merely a social status certificate, a certificate of belonging to a higher social class (no matter actual skills and abilities). I myself am from a third-world social shithole and never went to a high school. I could, however, beat a vast majority of so-called liberal arts majors and even some Stanford grads, which I regularly did on this very site before CoCs and bans for use of an "inappropriate" language. So, there is nothing much to talk about. A crappy degree is a social status certificate, and obsession with language usage, long-words and polit- correctness and fancy abstract terminology is merely a signaling of assumed, self-proclaimed (and almost always absent) virtue. ------ Proven Lost me during the Warren donation paragraph. A learned person wouldn't support Warren so I am certain I've nothing of value to learn from the article. Up to the Warren paragraph I realized socialist-leaning parties suck more than illiberal democracy. No wonder globalists and socialists can no longer win in Europe. College degree is non-essential for most people, unnecessary for at least 50%. ------ whatsmyusername TBH I'm indifferent to the rural working classes plight. I'm LGBT and they've proven time and time again that they aren't my friends (both growing up in flyover country and later after I escaped that wasteland by how they vote and how they treat my brothers and sisters who didn't escape). If they want to vote against our shared interests and suffer the consequences, so be it. Me and mine will keep building without them and I won't spare a moments thought for their self inflicted suffering (except to be glad it isn't me). ~~~ WillDaSilva I completely understand your position, and sympathize with it, but it seems a bit shortsighted given that you have to live with these people, and things won't improve for your "brothers and sisters who didn't escape" if things don't get better for them. They'll happily drag you and yours down with them. This is all to say that we're all in this together, and while your indifference towards their plight may be justified, it is not productive. ~~~ anonsivalley652 In general: Give hate and antipathy no quarter. Where there is pain, it must our pain, or there will inevitably be revolution and chaos. Love without discrimination, even with those you disagree with, because they cannot be moved if we act like impetuous children by refusing to talk to them. Prejudice also cannot be convenient, or we likely possess internal inconsistencies we must face if we are to be
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262, 11158, 11618, 322, 422, 10643, 304, 3358, 2056, 11618, 1889, 5556, 261, 572, 30511, 82, 60, 489, 62, 288, 10441, 316, 708, 22458, 739, 23611, 396, 1291, 74, 17502, 261, 275, 5457, 739, 8032, 2853, 66, 26453, 965, 4977, 6357, 34239, 282, 8960, 3346, 275, 440, 312, 944, 2555, 312, 1865 ]	BF1B25746C00786CE1" BuildableName = "微博@iOS程序犭袁.app" BlueprintName = "微博@iOS程序犭袁" ReferencedContainer = "container:微博@iOS程序犭袁.xcodeproj"> </BuildableReference> </BuildableProductRunnable> </ProfileAction> <AnalyzeAction buildConfiguration = "Debug"> </AnalyzeAction> <ArchiveAction buildConfiguration = "Release" revealArchiveInOrganizer = "YES"> </ArchiveAction> </Scheme> Strategic Impact This project will have impacts in the following six spheres: Development of tools and standards: The publication of the WHO guidelines Ensuring Balance in National Policies on Controlled Substances, guidance for accessibility and availability of controlled medicines in 10 languages, will provide an up-to-date and internationally agreed standard for policy and decision makers in Europe and other countries. This publication is an update of the older guidelines Achieving Balance in National Opioids Control Policy. The development and introduction of the International Opioid Consumption Database will allow national governments, international organisations and the general public to access country specific opioid consumption data, which will promote transparency, benchmarking, measuring, monitoring of and comparison between countries on the current status and future improvements in opioid availability in Europe. National policy-making processes and access to pain medication and substitution treatment: The outcome of the research undertaken in 12 European countries will result in country reports including concrete recommendations for legislative changes. These reports will be presented to relevant ministries, national organisations and health-care professionals in the 12 countries. This is expected to lead to the adoption of policies allowing for improved access to pain medication and national action in the area of substitution therapy. Better treatment of opioid dependence would contribute to decreased mortality rates, most importantly due to decreased HIV and hepatitis C infections, as well as addressing issues related to the prevention of opioid abuse. National capacity building: The six-countries workshops, national follow-up conferences in 12 countries and the review training for national and external lawyers will directly and indirectly build national capacities among civil servants and national lawyers in the area of policies for pain management, palliative care and opioid dependence. In total, 12 civil servants and three attorneys or lawyers will be trained in recognising barriers to opioid access and in analysing controlled drug legislations. Through national symposia and media communications, many more will be informed about the rational use of opioid analgesics and of treatment of heroin dependence with long-acting opioids. Research collaboration and sharing of experiences in Europe: This project will stimulate close collaboration, both among the wide range of health-related professionals in the Country Teams, and among the six Country Teams participating in each of the two workshops. The multi-country workshops will ensure that the applied research (situational analysis, policy and legislative reviews and recommendations) and country specific experiences are shared among participating countries. This project represents a first initiative to undertake research into opioid availability at European level and it is likely to stimulate the creation of a network that will last beyond the duration of the project. Contribution towards the implementation of European policies: The ATOME project has an impact on the implementation of policies. It is elaborated as part of the overall framework of the WHO Access to Controlled Medication Programme. Moreover, it supports the implementation of the goals of the Council of Europe which has established that palliative care is an inalienable element of a citizen's right to health care and that it is therefore a responsibility of the governments to guarantee that palliative care – including adequate pain treatment - is available to all who need it. The Council of Europe also states that the differences in the availability and quality of palliative care throughout Europe need to be addressed through increased co-operation between countries. Impact on the patients and populations themselves: The project is expected to have a positive impact for people in need of pain medication, people with opioid dependence and, related to the latter, populations at risk for attracting HIV and HCV infections. For a wide variety of conditions, patients do not achieve pain relief (analgesia in medical terms) without the use of controlled medicines: for example in cancer pain, HIV neuropathy, diabetic neuropathy, chronic pain, surgery pain (both around and after surgery), traumatic pain and sickle-cell disease. Opioid dependence increases mortality rates due to the poor quality and uncertain strength of heroin on the illicit markets and countries with a high prevalence of untreated illicit opioid use relate to high transmission rates of blood-borne diseases like HIV and HCV, even for the non-opioid dependent part of the population. The ATOME project promotes equal access to opioid medication to millions of patients affected by the above medical conditions in 12 European countries.Abraham Wright (deacon) Abraham Wright (23 December 1611 – 9 May 1690) was an English theological writer and deacon. Life Wright was sent to the Mercers' chapel school in Cheapside, and was afterwards from 1626 at Merchant Taylors' school. He was elected scholar of St John's College, Oxford, on 11 June 1629, and matriculated on 13 November. He was especially favoured by William Juxon for his good elocution. He was elected fellow of his college in 1632, graduated B.A. on 16 May 1633, and M.A. on 22 April 1637. When William Laud received Charles I in St. John's on 30 August 1636, Wright delivered the speech welcoming the king to the new library, and after dinner he acted in the play Love's Hospital, by George Wilde, before the king and queen. St. John's had long been famous for its plays. Wright is said himself to have written a comic interlude called The Reformation, acted at St. John's about 1631. Deaconry On 27 September 1637, Wright was ordained deacon by Francis White (1564?–1638), Bishop of Ely, in the chapel of Ely House. In the same year he published at Oxford a collection of sixteenth and seventeenth century epigrams, which he called ‘Delitiæ Delitiarum.’ On 22 Dec. 1639 he was ordained priest by Bancroft, bishop of Oxford, in Christ Church Cathedral. He soon became a popular preacher, and preached before the king, before the university, and at St. Paul's (Wood, Athenæ Oxon. iv. 275; cf. Hist. MSS. Comm. 2nd Rep. App. i. 79). In August 1645, he was presented to the vicarage of Oakham, Rutland, by Juxon, his constant patron, but he was not inducted, as he refused to take the covenant (cf. his poem to Juxon in Parnassus Biceps). He was expelled from his fellowship by the parliamentary commission (Wilson, Hist. of Merchant Taylors' School, ii. 728), and became tutor to the son of Sir James Grime or Graham at Peckham, and ‘read the common prayer on all Sundays and holy days, and on principal feasts he preached and administered. About 1655 he was prevailed with to leave Peckham and to live in London, where he was chosen by the parishioners of St. Olave in Silver Street to be their minister and to receive the profits of that little parish, of which he was in effect the rector, though formally to take actual possession of the living he would not (as his nearest relation hath told me), because he would avoid oaths and obligations’ (Wood, Athenæ Oxon.) He continued to minister there four years, according to the rites of the church of England, but was obliged to withdraw in 1659. On the Restoration, he was offered a chaplaincy to Elizabeth of Bohemia, but he declined it and took possession of his living of Oakham. He refused several preferments and lived quietly in the country, busy with his parish and his garden (cf. Hist. MSS. Comm. 2nd Rep. i. 396, 398). Personal Wright was the son of Richard Wright, silk-dyer, of London, was born in Black Swan Alley, Thames Street, 23 December 1611; apparently his father was the Richard Wright who was warden of the Merchant Taylors' Company, 1600–1, 1606–7, and master 1611–1612. He died on Friday, 9 May 1690, and was buried in Oakham church. He married, in 1643, Jane, daughter of James Stone of Yarnton, Oxfordshire. His son James (1643–1713) was a noted antiquary and man of letters. Works Wright's works have each some peculiar interest. Besides the ‘Delitiæ Delitiarum’ and some lines in ‘Flos Britannicus,’ Oxford, 1636, he was author of: Delitae Delitiarvm Sive Epigrammatvm Ex optimis quibusq[ue] hujus & novissimi seculi poetis in amplissima illa Bibliotheca Bodleiana ... in unam corollam conne
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595, 247, 11142, 6680, 49010, 9141, 14662, 342, 4430, 2149, 27205, 4859, 285, 24805, 387, 247, 4389, 265, 11714, 281, 9510, 253, 47387, 1612, 273, 253, 3747, 263, 641, 15, 187, 187, 510, 2207, 13853, 830, 253, 2798, 273, 253, 18500, 428, 597, 18536, 327, 616, 2303, 14, 4065, 254, 285, 4647, 4723, 281, 253, 3625, 342, 616, 246, 607, 22267, 20435, 15, 380, 3747, 263, 641, 830, 247, 1729, 5931, 342 ]	and mounds of remains were found dumped on land registered to Hogwood Farm, where shocking conditions were exposed by the Sunday Mirror last month. Campaigners from animal charity VIVA discovered the graveyard near Brian Hobill’s farm. New pictures obtained last week clearly show the 12 skulls – some still with ear tags. VIVA founder Juliet Gellatley said: “We were appalled to find the pig graveyard in Hobill’s wood. Mounds of pig bones were piled high, covered in moss and undergrowth. (Image: Viva) (Image: Viva) “It’s a risk to human health. It also shows a blatant disrespect for these poor pigs who have endured a life of suffering and misery at the hands of the farmer. It’s so unnecessary. “Walking into woods strewn with bodily remains, I felt like I’d walked into the aftermath of a war zone. Unmarked graves for animals who were just a number. I found an ear tag ‘224’ next to the skull of a pig. “We found 12 skulls, jaws, shoulder bones and legs scattered around and a mound filled with rotting remains – like a macabre scene from a horror film. But these victims were alive and suffered and died for nothing.” The Sunday Mirror told last month how pigs crammed into a barn were found chomping on rotting carcasses. Sickening film taken by activists showed another dead hog with a huge wound being eaten by one of the 15,000 pigs packed into the farm. (Image: Viva) The skulls of two more pigs, a jaw bone and a leg that had been devoured in the same pen were a clear breach of DEFRA guidelines. Juliet went on: “Our initial investigation exposed widespread abuse in a disgustingly dirty ‘Red Tractor Approved’ factory farm. “Inside this hell hole we filmed cannibalism, sick dying pigs and wheelbarrows full of dead rotting animals. “Cannibalism is not natural behaviour for pigs and is caused by this bleak environment. “Now this shoddy graveyard shows a total disregard for animals. Government guidelines state the ‘burial or burning of fallen stock in the open is banned to prevent the risk of spreading disease from residues in the soil, groundwater or air pollution’.” (Image: Viva) VIVA campaigners were tipped off by a rambler who spotted the skeletons at the woodland in Warwickshire. Details have been passed to Trading Standards, Environmental Health and the Animal and Plant Health Agency. Juliet added: “Hogwood typifies institutionalised cruelty, sanctioned by government.” It is understood that Tesco officials inspected the farm in recent weeks. (Image: Viva) Tesco said: “We take animal welfare extremely seriously and expect producers to meet recognised standards as well as our own stringent, industry leading requirements. “Our dedicated agriculture team, Red Tractor and the Animal and Plant Health Agency visit farms regularly and any claims standards have not been reached are fully investigated.” Mr Hobill said: “The bones found in the woods are likely to pre-date the burial ban on fallen stock which was introduced in 2003. Before that time farmers were legally permitted to bury fallen stock.”The candle flame gutters. Its little pool of light trembles. Darkness gathers. The demons begin to stir. — Carl Sagan Before I struck out on my own, I was a member of Of Sound Mind, a newbie-oriented alliance primarily targeted at players with 15 million or fewer skill points. One of the alliance’s goals is to provide new players with a good cross-section of the game’s available activities, so we ran alliance fleet operations, small gang roams, solo training, collective industry and mining operations, and so on; any area a new player could hope to experience we had on offer, save one. Silence In The Deep Wormhole space has a well-deserved reputation as a lawless abyss inhabited by silent packs of deadly hunters. The lack of Local chat means an ambush can be prepared at any moment; a dozen enemy ships, often lethal strategic cruisers, can be cloaked and lying in wait. The wormhole-generation mechanic means virtually every entity lives “next door” at least part of the time, including groups you’d really rather not run into. Apart from the material hazards, visitors to Anoikis also have to contend with the Sleepers, a type of NPC unlike those seen anywhere in New Eden. Many sleeper ships field various forms of tackle and powerful, long-ranged energy neutralizers. Some sleeper ships also remote-repair each other, and all of them pack a powerful omni-typed punch. The Coin Of The Realm To match the unique difficulties, wormhole space offers unique rewards: the so-called “blue loot”, which can be sold to NPCs back in New Eden, and salvage, which is used by players to produce Tech 3 ships. Since Sleepers offer no bounties, all sleepers drop items of blue loot when killed, so that each sleeper ship has some payout. The most famous (and by far the most glamorous) form of wormhole PvE is the capital escalation. Sleepers, again unlike other NPCs, will warp in additional heavy battleships in response to a capital ship entering their site, and these battleships drop blue loot and can be salvaged just like all other sleeper ships. Used properly, this mechanic can allow dwellers in high-class wormholes to kill up to 40 extra Sleeper battleships per anomaly, worth a minimum of several hundred million extra ISK in blue loot alone. On The Cheap Profitable though it is, there’s a substantial barrier to entry for capital escalations — namely, having capital pilots and the courage to use them in the depths of wormhole space. In our quest for a group PvE activity we could do in wormhole space, eventually we managed to stumble onto a fleet composition and method that worked for us, but to explain it first I’ll have to set the stage. Home Sweet Home Some time ago, a newly-joining corp member revealed to us that he’d previously lived in J211915, known to those of us with short attention spans as “J”. He also revealed that he still had an alt logged off inside J in a covert ops ship with a probe launcher fitted. Eager to explore, we had him log on and locate the static high-security exit, then jumped a combat fleet in to take a look around. We were unsurprised to find that interlopers had moved into the wormhole. We inspected their towers carefully and decided that attacking them was beyond our capabilities, especially without support from capital ships, so we decided to try the stealthy approach and anchored a small starbase of our own. This tower, Endurance 1, would eventually withstand multiple assaults by the current inhabitants, eventually culminating in their losing an entire fleet of attack battlecruisers to a superb bombing run. This reverse was enough to make the other inhabitants sue for peace, and we formed a mutual defense pact. Conveniently, they were mostly Chinese, and we were mostly American, so we could cover each others’ timers nicely. Taking The Plunge J* actually has two static exits: one B274 exit to high-security space, and one Y683 exit to a class 4 wormhole. After we moved in and made peace with the other inhabitants, we quickly deduced that even two or three of us could trivially handle all the sites available in J* itself. Lured in by the promise of greater rewards, we formed a fleet of combat battlecruisers with shield logistics and jumped into our C4. The result was a disaster. We tried several times, each time grinding through the sites slowly, each time losing at least one ship to overwhelming damage and neuting power from the Sleepers. Determined, we furiously mutated our fleet composition, switching from shield to armor in search of a heavier tank and from combat battlecruisers to attack battlecruisers for greater range and projection. Eventually, we had the key insight that a pair of armor logistics ships could effectively transversal-tank much of the Sleepers’ damage, allowing us to run sites with only two logistics instead of three. Converging At Infinity As we iterated, we eventually derived what seemed to be an ideal fleet composition: A few heavily tanked armor Oracles, for heavy, long-range damage and tank alike; A pair of Augorors using the odd Of Sound Mind standard fit, providing enough repairing power to tank even the most dangerous waves of Sleepers; An armor cruiser (usually a Thorax or a Stabber) filling two roles: webbing and target-painting the primary, and cleaning up any frigates that managed to get too close to the Oracles; A Maller fitted with tractor beams and salvagers, to salvage sites as we went. Optionally a cheap battlecruiser fitted with armored warfare links and parked at a safespot to boost the repairing power of the Augorors. The Oracles form the heart of the fleet - they anchor on their target-caller and apply damage to the primary with their tachyon beams. The Augorors form a cap chain with
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3981, 13, 686, 4045, 16914, 564, 4600, 342, 619, 26283, 13, 253, 2500, 404, 273, 731, 13, 285, 452, 1016, 581, 273, 731, 187 ]	and how enjoyable and delectable!" Quoth she, "And where is this compared with that I would relate to you on the coming night an the Sovran suffer me to survive?" Now when it was the next night and that was The Eight Hundred and Thirty-third Night, Dunyazad said to her, "Allah upon thee, O my sister, an thou be other than sleepy, finish for us thy tale that we may cut short the watching of this our latter night!" She replied, "With love and good will!" It hath reached me, O auspicious King, the director, the right-guiding, lord of the rede which is benefiting and of deeds fair-seeming and worthy celebrating, that the grass- widow came forward beside her stepson and raised her raiment from her behind until the half of her below the waist was stark naked; and she did even as her husband's son had done, and perked up her buttocks, leaning heavily upon her knees and elbows. Now when she acted on this wise the youth addressed her saying, "Thou canst not do it aright." "How so?" "Because the wind passing in through the postern passeth out through thy portal, thy solution of continuity." "Then how shall I do?" "Stopper thy slit wherethrough the air passeth." "How shall I stopper it?" "An thou stopper it not thy toil will be in vain." "Dost thou know how to stopper it?" "Indeed I do!" "Then rise up and stopper it." Hearing these words he arose, because indeed he greeded for her, and came up behind her as she rested upon her elbows and knees and hending in hand his prickle nailed it into her coynte and did manly devoir. And after having his will of her he said, "Thou hast now done thy best for me and thy belly is filled full of the warm breeze." On this wise he continued every day, enjoying the wife of his father for some time during his wayfare, till the traveller returned home, and on his entering the house the bride rose and greeted him and said, "Thou hast been absent overlong!"[FN#589] The man sat with her awhile and presently asked of her case for that he was fearful of his son; so she answered, "I am hale and hearty!" "Did my son ask thee of aught?" "Nay, he asked me not, nor did he ever address me: withal, O Man, he hath admirable and excellent expedients and indeed he is deeply versed in natural philosophy." "What expedients and what natural philosophy?" "He tucketh up his dress and exposeth his backside to the breeze which now passeth into his belly and benefiteth him throughout the cold season, and in winter he doeth exactly what he did in summer with effect as beneficial. And I also have done as he did." Now when the husband heard these her words he knew that the youth had practised upon her and had enjoyed his desire of her; so he asked her, "And what was it thou diddest?" She answered, "I did even as he did. However the breeze would not at first enter into my belly for whatever passed through the back postern passed out of the front portal, and the youth said to me, 'Stopper up thy solution of continuity.' I asked him, 'Dost thou know how to stopper it?' and he answered, 'Indeed I do!' Then he arose and blocked it with his prickle; and every day I continued to do likewise and he to stopper up the peccant part with the wherewithal he hath." All this was said to the husband who listened with his head bowed groundwards; but presently he raised it and cried, "There is no Majesty and there is no might save in Allah, the Glorious, the Great;" and suddenly as they were speaking on that subject the youth came in to them-- And Shahrazad was surprised by the dawn of day and fell silent and ceased to say her permitted say. Then quoth her sister Dunyazad, "How sweet is thy story, O sister mine, and how enjoyable and delectable!" Quoth she, "And where is this compared with that I would relate to you on the coming night an the King suffer me to survive?" Now when it was the next night and that was The Eight Hundred and Thirty-fourth Night, Dunyazad said to her, "Allah upon thee, O my sister, an thou be not sleeping, finish for us thy tale, that we may cut short the watching of this our latter night!" She replied, "With love and good will!" It hath reached me, O auspicious King, the director, the right-guiding, lord of the rede which is benefiting, and of deeds fair-seeming and worth celebrating, that the youth came in to his father and found his stepmother relating to him all they had done whilst he was away and the man said to him, "Wherefore, O youth, hast thou acted on such wise?" Said the son, "What harm have I done? I only dammed the waterway that the warm air might abide in her belly and comfort her in the cold season." So the father knew that his son had played this trick in order to have his will of her. Hereat he flew into a fury[FN#590] and forthright divorced her, giving her the contingent dowry; and she went her ways. Then the man said in his mind, "I shall never get the better of this boy until I marry two wives and ever keep them with each other, so that he may not cozen the twain." Now after a couple of weeks he espoused a fair woman fairer than his former and during the next month he wived with a second and cohabited with the two brides. Then quoth the youth in his mind, "My papa hath wedded two perfect beauties and here am I abiding in single blessedness. By Allah, there is no help but that I play a prank upon both of them!" Then he fell to seeking a contrivance but he could not hit upon aught for that whenever he entered the house he found his two step-mothers sitting together and thus he could not avail to address either. But his father never fared forth from home or returned to it without warning his wives and saying, "Have a care of yourselves against that son of mine. He is a whoremonger and he hath made my life distraught, for whenever I take to myself a wife he serveth some sleight upon her; then he laugheth at her and so manageth that I must divorce her." At such times the two wives would cry, "Walláhi, an he come near us and ask us of amorous mercy we will slap him with our slippers." Still the man would insist, saying, "Be ye on your guard against him," and they would reply, "We are ever on our guard." Now one day the women said to him, "O man, our wheat is finished," and said he, "Be ye watchful while I fare to the Bazar in our market- town which lieth hard by and fetch you the corn." So he left them and made for the town,--And Shahrazad perceived the dawn of day and fell silent and ceased saying her permitted say. Then quoth her sister Dunyazad, "How sweet and tasteful is thy tale, O sister mine, and how enjoyable and delectable!" Quoth she, "And where is this compared with that I would relate to you on the coming night an the Sovran suffer me to survive?" Now when it was the next night and that was The Eight Hundred and Thirty-fifth Night, Dunyazad said to her, "Allah upon thee, O my sister, an thou be other than sleepy, finish for us thy tale that we may cut short the watching of this our latter night!" She replied, "With love and good will!" It hath reached me, O auspicious King, the director, the right-guiding, lord of the rede which is benefiting and of deeds fair-seeming and worth celebrating, that when the father had gone forth and was making for the market-town, his son happened to meet him, and the two wives went up to the terrace wishing to see if their husband be gone or not. Now by the decree of the Decreer the man had in some carelessness forgotten his papooshes so he turned to the youth who was following him and said, "O my son, go back and bring me my shoes." The women still stood looking, and the youth returned in mighty haste and hurry till he stood under the terrace, when he looked up and said, "My father hath just now charged me with a charge saying, 'Do thou go sleep with my wives, the twain of them, and have each one of them
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1084, 926, 20, 910, 709, 14, 881, 568, 926, 986, 50001, 22, 1084, 926, 22, 910, 709, 14, 881, 568, 926, 986 ]	observer in executive functions and ASD using the ad hoc observation instrument. ### Control of the Quality of the Data {#sec10} The quality of the observational data was controlled using two guidelines ([@ref5]): (a) Qualitative: consensual agreement was used in the first session to be coded for each participant (therefore, a total of eight sessions) by three expert observers in observational methodology, ASD and executive functions; (b) Quantitative: (b1) intra-observer reliability was calculated in three sessions for each child: one belonging to task 1, another to task 6 (both sessions randomly chosen) and the post intervention task session. We selected sessions of these three tasks because these tasks were the ones analyzed in this study, as will be explained later; (b2) inter-observer reliability was also calculated in three sessions for each child: one of task 1 and one of task 6 (randomly selected sessions but taking care that they were different from those used for the calculation of intra-observer reliability) and the post intervention task session. Cohen's kappa coefficient ([@ref21]) was calculated using software program GSEQ5, v.5.1. All results obtained are between 0.84 and 1.00, which according to the scale suggested by [@ref47] corresponds to a very good agreement. Therefore, the quality of the observational data obtained was excellent. Data Analysis {#sec11} ------------- ### Lag Sequential Analysis {#sec12} Lag sequential analysis was proposed by [@ref12], and subsequently extended by [@ref13], [@ref14], and [@ref65]. It is a highly effective data analysis technique for analyzing datasets compiled from observation that contain sequences of behaviors that are coded using an ad hoc observation instrument. It allows to detect those patterns of behavior, which occur with greater probability than would be predicted by chance. That is, starting with a behavior considered as a pattern generator (criterion or given behavior), and that tends to be chosen according to the objectives of each study, it looks for which other behaviors appear associated with the same with a probability greater than mere chance (conditional behaviors), both later (positive lag: +1, +2, etc.), and earlier (negative lag: −1, −2, etc.). In this way, prospective and retrospective patterns are obtained. In our investigation, these patterns allowed us to identify the sequential structure of the behaviors that the participants performed in interaction with the adult at the beginning and end of the intervention, as well as 1 month after the end of the intervention. The comparison of the patterns obtained in these three temporary moments allowed us to know their progress in the use of planning skills. This technique has been widely used in studies that analyze sports behavior, but its use in studies in the educational field is somewhat sparse ([@ref39]; [@ref73]; [@ref36]; [@ref31]). Especially, scarce are the studies with ASD students in which this data analysis technique has been used ([@ref18]; [@ref69]). We are unaware of works in which this data analysis technique has been used to evaluate planning skills in ASD children, a novel issue that is addressed in this work. In our study, the records of the participants were joined according to their SL (SL1 or SL2) and the task to which they corresponded. In each group of participants (SL1 and SL2), three tasks were analyzed: task 1 and task 6 (as they were the tasks that best allowed us to know the improvement of each group during the intervention when comparing the planning skills used at the beginning and at the end of the intervention) in addition to the post intervention task (this reflected the possible maintenance of the improvement after 1 month without intervention). To perform lag sequential analysis for each group and task: (1) the same criteria behaviors were chosen: those categories considered most relevant depending on the objective of the study given that they play a central role in planning skills and the resolution of daily activities. Specifically, the following categories---appearing alone or co-occurring with others---were chosen (categories indicated in bold in [Figure 1](#fig1){ref-type="fig"}): (1a) of those referring to participants: (i) all of criterion 4 Execution: No response (NR), Unrelated behavior (Ds), Wrong use of strategy (UesEr), Change to a wrong strategy (CesEr), Correct use of strategy (UesC) and Change to a correct strategy (CesC), as they indicated the accuracy of the response/answer that the participants issued during the execution of the activity as well as their flexibility to change the strategy; (ii) of criterion 5 Control, categories Checking break (Ic) and Regulation (Rg) given that they showed the existence of check behaviors of the participants on their own action and its quality; (iii) of criterion 6 Error detection, categories No error detection (Nde) and Error self-detection (Ade) as they showed the ability of the children to update their own activity during the performance of the task and therefore to detect or not the errors produced; (iv) all categories of criterion 7 Evaluation: Non adjusted evaluation (Ena) and Adjusted evaluation (Eva) because the evaluation informs about the children's ability to distinguish whether an objective has been achieved or not, and examine their execution/result comparatively with the demands of the task; (1b) of those categories referring to the adult, all ones of the observation instrument belonging to criterion 2 Adult help for the child to carry out the activity: Error correction (Adc), Direct help (Adp), Indirect help (Ayi), and Motivating help (Aym). They were chosen because they involved scaffolding strategies that provided support for the children in carrying out the tasks; (2) as given behaviors, all the categories that make up the observation instrument ([Figure 1](#fig1){ref-type="fig"}) were considered; (3) lag sequential analysis were performed prospectively (from +1 to +5 lags) and retrospectively (from −5 to −1 lags); (4) the level significance was set at p \< 0.05. Results {#sec13} ======= Of all the patterns obtained (61 retrospective and 45 prospective patterns in SL1 group, 34 retrospective and 35 prospective patterns in SL2 group), the most relevant for this study are described below. They are the most relevant because: (a) are generated by the children or (b) they are generated by the adult but contain infant's and adult's behaviors. Therefore, these patterns are those allow us to know the use of infant's planning skills. Consequently, the patterns generated by the adult that only contain adult's behaviors are not relevant and they are not described. Hence, the patterns generated by each group of participants in each task analyzed are presented, in addition to the patterns generated by the adult that included behaviors of the participants of each group in each task. Thus, [Figures 3](#fig3){ref-type="fig"}--[5](#fig5){ref-type="fig"} contain the patterns of SL1 group and the patterns of the adult in task 1, task 6, and in the post intervention task, respectively; [Figures 6](#fig6){ref-type="fig"}--[8](#fig8){ref-type="fig"} contain the patterns of SL2 group and the adult's ones in the same tasks. Within each figure, the patterns of the participants appear organized increasingly based on the suitability that the criterion behavior implies for the resolution of the task. Therefore, those patterns of the participants whose criterion behavior is less suitable are presented first and then those in which their criterion behavior is more appropriate. Adult patterns are presented starting with those whose criterion behavior implies more direct adult help to the participants and ending with those who assume less direct adult help. [Figures 9](#fig9){ref-type="fig"}--[11](#fig11){ref-type="fig"} show the comparison of patterns obtained in each task for each group. ![Prospective and retrospective patterns obtained in SL1 group. Task 1.](fpsyg-10-02824-g003){#fig3} ![Prospective and retrospective patterns obtained in SL 1 group. Task 6.](fpsyg-10-02824-g004){#fig4} ![Prospective and retrospective patterns obtained in SL 1 group. Post intervention task.](fpsyg-10-02824-g005){#fig5} ![Prospective and retrospective patterns obtained in SL2 group. Task 1.](fpsyg-10-02824-g006){#fig6} ![Prospective and retrospective patterns obtained in SL2 group. Task 6.](fpsyg-10-02824-g007){#fig7} ![Prospective and retrospective patterns obtained in SL2 group. Post intervention task.](fpsyg-10-02824-g008){#fig8} ![Comparison of the patterns obtained in each group in task 1.](fpsyg-10-02824-g009){#fig9} ![Comparison of the patterns obtained in each group in task 6.](fpsyg-10-02824-g010){#fig10} ![Comparison of the patterns obtained in each group in the post intervention task.](fpsyg-10-02824-g011){#fig11} To facilitate the jointly reading of the patterns described and its representation in the Figures we indicate at the beginning of each paragraph the code and name of the criterion behavior that generated the patterns described. [Figures 3](#fig3){ref-type="fig"}--[5](#fig5){ref-type="fig"}
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22, 13, 470, 13, 470, 10, 187, 187, 1147, 434, 253, 1072, 347, 1214, 43, 28024, 5125, 13, 816, 247, 1027, 13, 625, 34025, 281, 479, 13, 16144, 187, 187, 34, 27, 187, 187, 1909, 1214, 53, 333, 1099, 740, 20503, 13, 48703, 64, 17037, 310, 8884 ]	* Dropped Laravel <6 support * Dropped Symfony <4.4 support * Dropped PHP <7.2 support 1.1.0 ----- * Added Laravel 5.6, 5.7 and 5.8 support * Dropped Symfony 2.8 support * Dropped PHP 7.0 support 1.0.2 ----- * Added `Schema::connection()` to allow multiple connections 1.0.1 ----- * Added support for env variable usage in connection settings 1.0.0 ----- * Added Symfony 4.0 support * Added form type guesser * Added Var Dumper caster for Eloquent models * Added the `eloquent:make:seeder` command * Added the `eloquent:migrate:fresh` command * Added discovery of `App\Seed\DatabaseSeeder` when using Symfony Flex * Added Laravel 5.5 support 0.5.0 ----- * Fixed not creating the migrations directory on `eloquent:migrate:make` * Added Data collector * Added Laravel 5.4 support 0.4.0 ----- * Added `@internal` and `@final` PHPdoc annotations * Added model events integration * Deprecated `postgres` and `sql server` driver names in favor of `pgsql` and `sqlsrv`. The old names will be unsupported as of 1.0. 0.3.0 ----- * Added `wouterj_eloquent.migration_path` parameter to store the migration path * Added incompatibility for Laravel 5.3+ packages ([37aceab](https://github.com/wouterj/WouterJEloquentBundle/commit/37aceab0ede2af755b96c7d7356b8698a8efcca2) - theofidry) * Refactored booting of eloquent and facades to use `Bundle#boot()` ([669e9f4](https://github.com/wouterj/WouterJEloquentBundle/commit/669e9f4e05a6d6179e046c80af5e606878d413ce) - wouterj) * Required at least one connection ([7228be3](https://github.com/wouterj/WouterJEloquentBundle/commit/7228be36e1827bc75690c970a3390e1b32f69467) - wouterj) New Election Fraud Task Force November 3, 2014: Philadelphia District Attorney Seth Williams has created a new task force that will investigate and prosecute all allegations of criminal activity during elections. The new Election Fraud Task Force is part of the office’s Special Investigations Unit (SIU), and is comprised of ADAs and detectives who will be specially assigned to Election Day allegations. In the past the investigation and prosecution of Election Day crimes were assigned based on where and when the complaints came into the office. “This Task Force is another tool for my office to ensure that all crime in Philadelphia is investigated thoroughly, and prosecuted swiftly,” said District Attorney Seth Williams. “For far too long it has been assumed that Election Day in Philadelphia involves inappropriate actions at the polls. I want those assumptions to end now. The new Election Fraud Task Force helps guarantee that my office will not only thoroughly investigate Election Day complaints, we arrest and prosecute the culprits.” “No eligible Philadelphia voter should be impeded from casting a ballot,” said Ellen Mattleman Kaplan Interim President and CEO of the Committee of Seventy. “The Committee of Seventy applauds the District Attorney’s Office for taking aggressive and prompt action to investigate and, if appropriate, prosecute anyone who engages in elections-related criminal conduct.” “The District Attorney has shown a real commitment to making the integrity of elections a priority,” added City Commissioner Al Schmidt. “The creation of the Election Fraud Task Force will help Philadelphians be confident that elections in our city are conducted in a fair manner.” Today, the Election Fraud Task Force charged 64-year-old Oxana Turetsky of the 1200 block of Unruh Avenue with Tampering with Records, Criminal Mischief and Tampering with Voting Machines. Ms. Turetsky is scheduled to turn herself in to authorities later today. On May 20, 2014, police responded to a complaint at the polling location for the 53rd Ward, 13th Division of Philadelphia on the 6900 block of Summerdale Avenue. The Judge of Elections there notified police that Oxana Turetsky had written her name in ink on the voting machine at that location. Upon inspection, the officer confirmed that the name “Oxana Turetsky” was handwritten on the machine next to the box for “write in” candidates. Turetsky, a write-in candidate for committeeman, later admitted to writing her name on the voting machine. In February of this year, the Election Fraud Task Force charged 65-year-old Dianah Gregory with Fraud by Election Officers, Tampering with Records, Criminal Mischief, and Tampering with Voting Machines for her actions during the November 5, 2013 election. Dianah Gregory pleaded guilty to Tampering with a Voting Machine in an open plea on May 27, 2014. She was sentenced by the Honorable Michael Erdos to fifteen (15) months of probation. The investigation into Dianah Gregory began when the Philadelphia District Attorney’s Office received a complaint on Election Day at the Ethel Allen School polling site located at 31st & Lehigh Avenue. On location, a candidate for “Judge of Election,” William Thompson, explained that a voter left the polling site visibly upset after Dianah Gregory reportedly entered the voting booth and attempted to make a “write in” vote on the voter’s behalf. The voting booth was then examined as part of the investigation. The detective observed the name “Dianah Gregory” was written in marker on the voting booth. The name was scrawled next to the button to select a “write in” candidate. Still on location, Dianah Gregory admitted that she wrote her name on the voting machines, as she explained, for voters to know how to spell her name. Share this: Like this: LikeLoading... Related This entry was posted on November 3, 2014 at 5:48 am and is filed under Press Release. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.The author was not comparing the levels of violence, the author was comparing the levels of extremism. I think this paragraph says it pretty well. "So, just as Christianity and Islam have their extremist groups doing whatever they please in the name of “the greater good,” so does the hacker community. These people are nothing more than self-absorbed, self-righteous, immature, spoiled rotten, egotistical cyber-bullies. They’re terrorists of the internet... #5.1.2Frank Gifford's family reveals former NFL star suffered from CTE USA TODAY Sports \| USA TODAY The late Frank Gifford, the former New York Giants star and 1956 NFL MVP, suffered from the degenerative brain disease Chronic Traumatic Encephalopathy at the time of his death in August, his family said in a statement Wednesday. Gifford's family had decided to have his brain studied following his death to study the link between football and brain injuries from repeated head trauma. "During the last years of his life Frank dedicated himself to understanding the recent revelations concerning the connection between repetitive head trauma and its associated cognitive and behavioral symptoms—which he experienced firsthand," Gifford's family said in the statement. "We miss him every day, now more than ever, but find comfort in knowing that by disclosing his condition we might contribute positively to the ongoing conversation that needs to be had; that he might be an inspiration for others suffering with this disease that needs to be addressed in the present; and that we might be a small part of the solution to an urgent problem concerning anyone involved with football, at any level. "The Gifford family will continue to support the National Football League and its recent on-field rule changes and procedures to make the game Frank loved so dearly—and the players he advocated so tirelessly for—as safe as possible." Gifford was inducted into the Pro Football Hall of Fame in 1977 in honor of his 12-year career with the Giants. He also spent 27 years as an announcer for Monday Night Football.Q: how to check QT_VERSION to include different header? Qt4 and Qt5 have different organization of header files. So I need to check the qt version to include different things, for example: #if QT_VERSION >= 0x050000 #include <QtMultimedia> #endif however, this seems does not work. The QT_VERSION has not been defined. How can I solve this problem? A: As soon as you include <QtGlobal> you can check that with macros: #if QT_VERSION < QT_VERSION_CHECK(5, 0, 0) It's the same as @Javier suggested, just a different, more readable to me, syntax A: As @Tay2510 commented, QT_VERSION is declared
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346, 32783, 21695, 2726, 7464, 884, 3, 3239, 326, 3797, 4859, 327, 5743, 285, 247, 3167, 273 ]	t appreciate it as much if I didn’t work so hard for it, if I didn’t undergo the challenges of working as a nurse (a career which I love btw). I can’t imagine travelling full-time; even my 2-3 trips a year alone were tough to plan and execute, let alone the money I have to save for it. At the end of the day I want to be in a place I call home, living a life I’ve worked hard for (because that also brings me a sense of joy) and one that makes me happy (and that means being near friends and family, taking up hobbies and such) – even if it’s “normal”. Whilst I agree that advertising is evil and travelling for the sake of bloating ones own ego (and letting everyone know about it) can be seen as equally as horrid, consuming other cultures and expanding ones own experience is a point worth considering. Travelling is not just a form of escapism, it can give one a less insular world view and see humanity as a whole for what it is, what it isn’t, what it could be and what it should be. Great point. It is great to travel to expose yourself to different cultures, and getting out of town every once in awhile is always recommended! Everyone needs this in their life at some point in my opinion, too. Still learning how to make such a life for myself! Most of my travel the past three years has been the result of work, teaching in China, and even during those long stretches of time abroad, I took advantage of every opportunity to “get away” from my responsibilities, by visiting different areas most people outside China had never seen. I can look back on those experiences and consider myself lucky to be there; but I also regard them as periods of struggle, confusion, and anxiety, which have all taught me important things about myself and how I lead my life. One other thing I’ve learned from my travels is that you can be a traveler of your own home. What I mean is, you can experience your hometown like a traveler, approaching this world you’ve grown up in (or spent a great deal of time in) with new eyes. I think one of things that is most lost on us in mainstream living is that sense of awe or appreciation you encounter when you really do see something new, even if it’s right outside your door. Take it upon yourself to see a side of that world you never imagined existed. LOVE this! I see so many new “van lifers” on youtube, and I can tell that some of them are definitely fake and basically showing lots of skin so that they can make some money off of subscribers clicking like, etc. Two years ago, I moved away from my family and have moved about 4 times since. Your comment about how you don’t have those other friends around anymore really hit the nail on the head with me about that. One of the things I miss most about the east coast is my friends. And yes, it was $$$$$ to move! Each time! Great blog and really thoughtful post! I often wonder when people say ‘lucky you’, if they really think about what that means… travelling is something I always wholeheartedly recommend, from the perspective of having the chance to see something more of the world, but it involves working hard beforehand for the money, as well as during the travel, working with your mindset… because the main piece of luggage which you’ll always take with you, no matter how minimally you have packed, is yourself. And sometimes, that can weigh in at quite a few kgs 😉 Also, whilst I like travelling slow and for a long period of time, it always gets to a point where I want to be working and settled somewhere, to let life grow and blossom more slowly over time, have regular meetings with regular friends, and contribute properly to something- building a life from which I don’t want to escape, indeed! But I think the travel can often give you the perspective to appreciate this latter golden nugget 🙂 That was a really elegant way to put it! ” the main piece of luggage which you’ll always take with you. . . , is yourself.” And it is good to become a tourist in your own city every now and then, but also to travel outside your comfort zone.Thanks for commenting! Love it. And you are exactly right in my view. Creating a life you don’t want to run away from is so important. That’s not to say that you shouldn’t want to travel. I do want to travel, and I have travelled. But I have to work to make it happen, and other commitments sometimes hold me back. Such is life, it is not just one big escape. That will catch up with you in the end I think. A really interesting post 🙂 Well said. To which I would add, “don’t pass through a city in a day, give each place time to work its magic on you”. I might travel halfway around the world to visit a country but I won’t whizz through it when I get there, I’ll just do two or three places in maybe two weeks. Enjoying your posts. Sound advice, don’t go travelling for travelling’s sake. I traveled around Europe in 1986 because I got accepted to the University of London and intended to spend a year in England studying, which I did. However that one year has now become 31 years. Wise words. So many discontented people when the answer is in their backyard. It’s why I’ve never drawn up a bucket list – it creates a sense of alienation from your life and loved ones and what happens if you can’t fulfil it? More discontent and a sense of failure. I’ve always followed “It seemed like a good idea at the time” and had lots of adventures including travel but not by design, more by happenstance. The ultimate travel – a loved person once whispered into my ears as I was at the airport, bidding farewell before a long trip “Enjoy the travel within, which is the best of all trips…” – is the trip within ourselves… I am 100% with you when you say “create a life you do not have to escape from”. Know what you are seeking to find when you think of escaping… and bring it into your life for good! Then you can have it everyday AND when you travel. How great would that be? Thank you for the post. Recently, the thought of “creating a life I don’t need to vacation from” came back to me. This post also serves as a reminder of the same. I have been sensing the minimalism call in my life. Again the post is a reminder. Great post. If we never had to work to earn our travel dollars, would we ever fully appreciate the travel? And if we are only travelling to put another notch on our travel belt or complete some bucket list, would we ever be satisfied enough to enjoy the destinations for what they are? As to being nomadic, I moved 28 times in the first 17 years of life and 6 times in the next 3. That knocked the nomadic right out of me. Since then, I have moved only 4 times in 44 years. Much as I love to travel, it is always nice to have a home base to come back toEven though one of Microsoft's goals with Windows 10 seemingly was to simplify its upgrade and deployment processes, the company introduced some new and very different ways with Windows 10 that Microsoft didn't do much to explain. Until now, that is. Over the past couple of days, Microsoft has quietly made available some new web resources providing some much-needed guidance on how product activation and updating work with its new operating system. Microsoft officials had shared a few tidbits in August with ZDNet's Ed Bott around how the company's activation policies had changed with Windows 10. But now there's an official and more fully documented web page that explains the various paths to activation that the company is now enabling with the operating system. (Thanks @WinObs, a k a Richard Hay, for tweeting a link to the new activation page.) In order to decipher the new "Activation in Windows 10" page, a couple of definitions first need to be understood."Activation" is the process via which Microsoft attempts to verify that a copy of Windows is "genuine." And "digital entitlement" is Microsoft's name for the new method of activation in Windows 10 that doesn't require users to enter a product key. more ed bott Troubleshooting and repairing Windows 10 problems The Anniversary Update to Windows 10, version 1607, has been rolling out for the past few weeks, and some early adopters are experiencing issues. Here's Ed Bott's guide to some specific fixes for known issues along with time-tested troubleshooting tools and techniques. Read More "Depending on how you got your copy of Windows 10, activation will use either a digital entitlement or a 25-character product key," Microsoft's new resource page states. The page then goes on to list a handful of different ways users potentially may have gotten Windows 10 -- ranging from upgrading for free from Windows 7 or 8.1, to buying a copy of the product from a retailer or on a new device -- and the required activation method. There are a number of subsections linked from the main page, including how to activate after reinstalling Windows 10; activating the latest Windows 10 Insider Preview; and activating Windows 10 after a hardware configuration change.after a config change. Microsoft also has a "Need Help With Windows 10" page that includes links on activation and a host of
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6755, 3719, 13, 285, 1249, 16, 1229, 16, 6755, 3719, 4745, 1705, 281, 2564, 1108, 253, 1265, 14, 936, 14, 43020, 731, 1420, 2685, 273, 247, 873, 1108, 3782, 247, 6618, 3719, 1108, 369, 581, 273, 253 ]	only is it huge (20×30), but it’s a split perspective of the same image, one from the sky, one from below the waters. On the left there is a boy and a girl sitting high above the water in a patch of flowers, watching sailboats below and fireworks in the distance. On the right side is the image from below the water, with sharks swimming towards a light, deep below the sailboats, next to scuba divers. It’s really a fantastic poster and I’m thankful to have got a copy. Point is, all the posters are beautiful! Wonderful job from all the artists! Thank you! Most Unexpected Part Of Tour The Rain Harpua The Tight Rotation of Songs The end of mkdevo 3 Set Show at Chicago Honorable Mention: Hollywood Harry Hood a.k.a. HollyHOOD Summer 2013 was a unique tour for Phish for a plethora of reasons. There were a lot of unexpected surprises, some good, some bad, but all having an effect on the tour in one way or another. The biggest may be what happened to @mkdevo and all of his videos. For all of 3.0, if there was a song you wanted to check out and watch, everyone knew look no further than mkdevo. If you missed a show, no problem, you could watch it practically through his videos. The videos were arguably Phish’s greatest marketing tool as they were free and they exposed Phish to a generation of fans who never knew of the band before 2009. It’s definitely been a different tour with little to none visual footage as there has been in years past. Another big surprise was the Harry Hood from Hollywood, otherwise known as HollyHood. The last show of a 4 night stand between San Fran->Los Angeles, Hollywood was characterized by no new songs and lots of great, but typical, Phish excellence. All of the sudden, out of nowhere in the second set though comes this beauty. This magnificent mother of god Harry Hood that is instantly an all-timer. The song that started it all off in Bangor and never let down throughout the tour peaked in full capacity that Monday night, and that was a huge unexpected gift. It’s been said a bunch already, but 2012 and 2013 were very different. The chase for 200 songs changed the dynamic of the tour in 2012 and therefore 2013 not only had a much tighter rotation, but it truly felt like a tighter rotation. It made for interesting sets. There was plenty of variety among each jam and development and improvement with each play. The juxtaposition between the two summer tours was evident and unexpected. But by far, the most unexpected part of the tour was the rain. Without the rain you don’t get the Chicago run – Friday’s cancellation, Saturday’s three set speciality, and Sunday’s Harpua. The rain was EASILY the biggest factor throughout the east coast, all the way through Chicago, with everyone jokingly calling it Phish Pours America and Phish Summer Pour 2013. Every night there seemed to be a storm or threats of storms, starting with SPAC having delays and thunderstorms. Jones Beach’s show was caught in the middle of the worst storm of the summer on Long Island, with the wind whipping people in the face and the rain pounding on all of us from above. The rain didn’t stop though, it just continued, down to Merriweather and Atlanta, before finally “peaking” in Chicago. When the show on Friday was cut short, the band was truly devastated, and rewarded us with three sets on Saturday. But when Sunday came and the first set was cut during Antelope, you could really tell how frustrated and annoyed the band was, especially Trey and Page. The rain was just a constant deterrent, but both the band and the fans NEVER let it get in the way. I’ll always remember this tour for the rain as will many, as the rain truly gave life to each and every show in a different, unique way. Show Of The Tour Holmdel, NJ – 07/10/2013 Columbia, MD – 07/14/2013 Chicago, IL – 07/21/2013 George, WA – 07/26/2013 George, WA – 07/27/2013 San Francisco, CA – 08/02/2013 San Francisco, CA – 08/04/2013 Honorable Mention: Saratoga, NY – 07/07/2013 The thing about this 2013 Summer Tour is that there really wasn’t a single bad show played. Seriously, you could throw any of these shows on and find numerous moments of full-band-connectivity. Even on their safest nights – 07/03 and 07/05 – even on the cancelled mess of 07/19, even when they came out with a song-based/energy affair on the second night of BGCA, each of these shows are still worth your time and your ears. Each display a Phish at the top of their game, attacking their shows no matter the style. And yet, for however strong as the tour is as a complete entity, their peak shows are simply based on an even higher level of musical connectivity, advanced experimentation, and evolutionary progression. From 07/10 and 07/14’s dedication to the band’s classics, representing an early peak for the tour, while displaying Phish’s desire to jam as a unified force, to 07/21’s show that – like the above jam segment – absolutely HAD to happen, to the string of shows at the Gorge on 07/26 and 07/27 that display the most consistent peak for the band in 2013, to the first and third night of SF that combined rarities and segues on 08/02, and a second set for the ages on 08/04, there’s just simply SO MUCH music we have to listen to from Phish moving forward. And, one cannot forget to mention the initial high-point of the tour – a show rightly praised when it happened, yet overshadowed now as the tour has unfolded – 07/07. We’ve truly been blessed throughout the entirety of this 2013 Summer Tour. The thought of the band continuing to build upon this at Dick’s and in the Fall is simply mind-boggling. Thankful is simply not enough. Top Run Saratoga Performing Arts Center, Saratoga Springs, New York: 3 Nights Merriweather Post Pavilion, Columbia, Maryland: 2 Nights The Gorge, George, Washington: 2 Nights Lake Tahoe, Stateline, Nevada: 2 Nights Bill Graham Civic Auditorium, San Francisco, California: 3 Nights Top run? How can one even decide…Between the magnificence and glory at Phish’s real life Gamehendge, Saratoga Springs, through the tri state area in New Jersey and Jones Beach, and the weekend run at Merriweather, almost every run was unique and special, loaded with stunning moments and overflowing with highlights. Lake Tahoe had great shows and the most special moment, Tweezer, and Bill Graham was the RIGHT way to end the tour, in the place where the birth of the counter culture happened. But one run stands above the rest — The Gorge. Like Phish’s last trip to the legendary venue, this weekend stand boasted complete shows filled with sick segues, exploratory jams and fantastic first and second sets. Night one at the Gorge had a AC/DC Bag, Timber, Wolfman’s Opener with a closing trio of McGrupp, Curtis Lowe and Melt. The first set was stunning as was the second set, which had an 18 minute Crosseyed and Painless, followed by Twist, Steam, Waves and a jam that has WAY TOO MUCH POTENTIAL, Twenty Years Later. Mango, Bug and Bowie!!! rounded the end, before a symbolic Rocky Top, signifying the awesome set, and then the moon howling Character Zero. The next night opened with a gorgeous Architect, the first Golgi of tour and then the first Curtain With of tour! After that came more great songs with Moma, Maze and the new debut, Say Something, a song I love. After Midnight ended the set with a tribute for J.J. Cale and kept the energy at an all-time high. The second set was even better! The famous Down with Disease->Undermind to start things off before another amazing highlight, Light->Sneaking Sally. A spacey and funky 2001 was nicely placed before a perfect ending trio – Walls of the Cave, Fluffhead and Run Like an Antelope. Talk about a two night stand. There are a few rules of Phish. Never miss a Sunday show. If you have the ability to go to a show, you go. Never miss Dick’s, and of course, Never miss The Gorge. For much of 2009 – 2012, no matter what musical leaps forward were made, Phish continually struggled with conceiving fully-flowing sets. While yes, there are exceptions – 08/07/2009 II, 06/27/2010 II, 10/16/2010 II, 05/28/2011 II, 07/03/2011 I, 08/15/2011 II, 08/19/2012 II, and 12/30/2012 II immediately come to mind – the start-to-finish thematic flow of a set – particularly a Set II – was one of the
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FtsZ inhibition: a promising approach for antistaphylococcal therapy. Staphylococcus causes a large number of animal and human diseases and has been considered as a major health concern. With the emergence of resistant strains of staphylococcus, like methicillin-resistant Staphylococcus aureus and vancomycin-resistant Staphylococcus aureus, the search for novel antibacterial targets has intensified. FtsZ, a bacterial cytoskeleton protein, is involved in cell division. FtsZ assembles into protofilaments in a GTP-dependent manner, and forms a dynamic Z-ring at the mid-cell position. The assembly dynamics of FtsZ in the Z-ring are regulated by the combined actions of several FtsZ-associated proteins. Furthermore, the interaction of FtsZ with accessory proteins is essential for their recruitment to the Zring. A disruption of this interaction perturbs the Z-ring formation. FtsZ inhibitors like PC-190723 have been suggested to inhibit the Staphylococcus cell division by perturbing the assembly and stability of FtsZ polymers. In this review, we discuss the assembly dynamics of Z-ring and its role in cell division. In addition, we highlight recent advances suggesting the potential of FtsZ as a drug target for antistaphylococcal therapy.Ten teenagers have been arrested in relation to a series of armed robberies and aggravated burglaries across Melbourne and Geelong. During one of the armed robberies a 67-year-old woman was struck over the head with a metal pole several times, said Sergeant Cameron Scott of Victoria Police. "She received facial injuries and was taken to hospital." CCTV footage shows one of the alleged thieves at a St Albans milk bar. Credit:Channel Seven That armed robbery was one in a rapidfire series of alleged crimes in four hours from midnight on Tuesday through Melbourne's western and north-western suburbs. Eight teenagers have been charged after alleged aggravated burglaries, armed robberies and attempted armed robberies of milk bars in Derrimut, Newport, St Albans and Deer Park. The males charged are aged between 16 and 18. When arrested on Thursday morning the group were in two cars, one of which was allegedly stolen during one of the raids. CCTV footage from one of the milk bars allegedly shows the youths storm in with their faces obscured. They begin aggressively smashing the glass counters with weapons, including a hammer.Australian bookmaker opens Bitcoin wagering 5th February 2018 / lee There has been some new ground broken in online betting as a new online bookmaker in Australia, called Neds, launched the country’s first Bitcoin-based betting platform. The operator announced last week that they would launch their new betting platform, which has been developed in-house, and is opening with Bitcoin-only trading on the site. There are plans to add other cryptocurrencies this year if there is enough demand to warrant it. Neds explained that they are accepting deposits and are issuing payouts in Bitcoin, but without any options to convert. The odds on the Bitcoin version of the Neds site will be identical those at their regular, main betting site, just instead that the wagers will be traded in milli-Bitcoins (one-thousandth of a Bitcoin). Neds CEO Paul Cherry explained that the drive was there to create something amidst all the of the Bitcoin frenzy, and it afforded people who had bought Bitcoins but didn’t know what to do with them, a chance to use them in a new way. The operator is also offering to cover up to 2.5% of any transaction fees that are incurred by moving Bitcoins to the Ends site. Neds was created by former Ladbrokes Australia CEO Dean Shannon and they launched their operator in October 2017. Mentioned offers may be restricted to new customers, T&C's apply. Older offers may be not valid anymore. See details directly at the bookmaker's website. 18+. Please Gamble Responsibly. * All mentioned odds were valid at the time of writing. Betting odds are subject to fluctuations. Please check the current odds with the respective bookmaker!Fiction publishers complained that 2017 was a difficult year to get attention in a fast-moving media climate that was intensely political. But some of the year’s best novels spoke to current events, whether directly (as in Mohsin Hamid’s refugee story Exit West) or indirectly (George Saunders’s Lincoln in the Bardo is about the Civil War, but its comments on race feel relevant to the present). Other common themes emerge: new parenthood, a search for identity, an obsession with the past. Several of them feature ghosts. But two elements unite every title on the list: compelling writing and fresh storytelling. 10. New People, Danzy Senna Riverhead Books Senna’s latest racial satire focuses on a multiracial couple, Khalil and Maria, in which each half is grappling with complicated feelings about identity. With humor, understanding and a touch of sympathy, Senna’s novel is both knowing and biting. Buy it on Amazon 9. Days Without End, Sebastian Barry Viking In this riff on the American frontier genre, narrator Thomas McNulty and his sweetheart John Cole live through a series of trials: performing as women in a saloon, fighting in the Indian and Civil Wars, escaping random attacks in Postbellum South and avoiding being caught as gay lovers. Their story is both simple and strikingly choreographed. Read the TIME review Buy it on Amazon 8. The Ninth Hour, Alice McDermott Farrar, Straus and Giroux The Little Nursing Sisters of the Sick Poor meet Annie at her lowest point: she’s pregnant, and her husband has just committed suicide. With help from the nuns, Annie and her daughter are spared from destitution—but the intervention has ramifications that echo through generations. McDermott offers up a version of sisterhood that’s both historical and relevant. Read the TIME review Buy it on Amazon 7. The Changeling, Victor LaValle Spiegel & Grau The myth of the bad mom gets the horror-story treatment in this novel, which takes place deep in the boroughs of New York City. Apollo Kagwa and his wife Emma Valentine are thrilled to welcome their first child, but soon after his birth, Emma feels a strange distance from her son—is this the boy she birthed, or some sinister imposter? The story cleverly interrogates parenting norms, racial prejudice and technological quandaries. Read the TIME review Buy it on Amazon Exit West, Mohsin Hamid Riverhead Hamid tells the story of a couple whose love story begins just as war breaks out in their city, which is unnamed but resembles Lahore. The only path to safety is through a series of enchanted doors that lead them, and a surge of other refugees from around the world, to western cities where they face new threats from the residents who’d prefer these migrants went back to where they came from. Read the TIME review Buy it on Amazon 5. Lincoln in the Bardo, George Saunders Random House In his first full novel, Saunders has gained an even wider audience, winning the 2017 Man Booker Prize for this historical ghost story about Abraham Lincoln. The night after his young son is buried, as the Civil War rages, the President visits the cemetery for a final farewell, only to be observed by a ragtag cast of souls who can’t bring themselves to leave their earthly remains behind. Read TIME’s conversation with Saunders Buy it on Amazon 4. Manhattan Beach, Jennifer Egan Scribner The Pulitzer Prize winner’s new novel, seven years after A Visit From the Good Squad, marks a move away from the experimental—this is a straight historical novel, set mainly during World War II. The book’s heroine, Anna Kerrigan, is a character perfectly calibrated for Hollywood, with verve, vulnerability, and a tough-as-nails glamour that transitions from her job as the first female diver to work on war ships to her nights in gangster-filled night clubs. Read the TIME review Buy it on Amazon 3. Transit, Rachel Cusk Farrar, Straus and Giroux Cusk’s second novel in a planned trilogy goes minimal on plot, maximal on observation. The plot structure in the book is the renovation of the narrator’s London flat, and the spirit of transformation is mirrored in her conversations: With her contractors, her friends, her old flame. Through elegant meditations on contemporary life, Cusk’s depiction of her narrator is not so much portrait as a photo negative—mysterious, poetic and in contrast to her world. Read the TIME review Buy it on Amazon 2. White Tears, Hari Kunzru Knopf Publishing Group The British novelist skewers American culture in this treatise on whiteness and cultural appropriation. Two young white men breaking into the music industry find success when they record random noises in a New York City park and discover the voice of a man who wasn’t there. They pass the recording off as a rediscovered blues song—only to learn their lie may be accidentally based in reality. The hunt for the truth takes them on an unnerving journey through
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277, 8, 2948, 569, 546, 7113, 652, 10468, 386, 298, 8, 2966, 21373, 1732, 862, 2271, 13, 14333, 826, 795, 16056, 920, 36097, 64, 1157, 40711, 458, 44189, 1321, 277, 8, 2906, 20168, 918, 13, 7460, 24018, 591, 7373, 624, 277, 8, 10442, 46302, 37762, 820, 24690, 1641, 1162, 372, 372, 40833, 546, 9750, 509, 11524, 262, 27530, 15, 329, 34613, 24241, 14, 251, 3311, 254, 1753, 298, 8, 2843, 29833, 711, 2505, 3205, 801, 44209, 546, 3060, 14484, 7950, 1003, 4057, 298, 8, 28474, 460, 372, 826, 9568, 87, 2241, 3316, 363, 4415, 15, 3035, 562, 250, 13, 402, 400, 386, 298, 8, 35040, 837, 3539, 339, 24241, 14, 29448, 7684, 7678, 277, 8, 34, 15, 416, 15, 308, 15, 44570, 284, 606, 13, 298, 8, 312, 860, 965, 7843, 372, 298, 8, 11524, 255, 372, 256, 386, 860, 1162, 372, 826, 4192, 11272, 372, 46158, 1061, 29324, 269, 2631, 632, 7678, 44583, 3293, 5398, 74, 26444, 33677, 2477, 447, 3443, 34594, 8296, 70, 4927, 3539, 2148, 546, 35896, 14, 35, 1221, 20232, 4057, 826, 772, 297, 78, 318, 7863, 372, 44134, 32142, 1942, 8143, 261, 440, 1774, 756, 287, 16886, 420, 372, 826, 1885, 400, 11272, 15, 31661, 74, 13460, 546, 14078, 6483, 4057, 298, 8, 257, 1987, 250, 711, 2654, 14330, 294, 3314, 955, 919, 298, 8, 580, 593, 372, 298, 8, 18913, 15, 187, 187, 17483, 68, 363, 250, 6987, 1872, 33800, 4684, 7678, 1474, 850, 4057, 826, 36783, 5043, 2969, 1162, 5043, 2570, 70, 40841, 371, 8, 251, 490, 263, 615, 826, 268, 31178, 853, 372, 38767, 21441 ]	éens par milliers, l'historien observe un mouvement inverse d'Asiatiques vers l'Europe quasi insignifiant : le groupe le plus fourni est sans doute constitué des charpentiers indiens, quelques dizaines, qui viennent travailler aux chantiers navals lisboètes, et dont certains font souche localement. Pour des achats européens de marchandises qui s'élargissent des épices vers les tissus, les ventes de vin et de lainages en Asie méridionale demeurent symboliques, obligeant, pour solder les comptes, à d'importantes sorties d'espèces d'Europe ou d'Amérique ibérique. Dans la phase qui précède la colonisation, les contacts directs entre Europe et Asie méridionale restent si limités qu'ils favorisent la persistance de mythes des deux côtés : fantasmes sur la richesse et la cruauté asiatiques, d'un côté, caricatures des « gens à chapeaux » dans les poses parfois les plus ridicules, de l'autre, comme on le voit sur les miniatures ou les parois des temples en Inde. L'effet visible produit par les Européens sur les sociétés sud-asiatiques paraît au total assez infime : en dehors de la naissance de quelques villes coloniales, qui restent des enclaves, et constituent des cités assez modestes en comparaison des capitales autochtones, il se résume pour l'essentiel à l'introduction de plantes américaines dont l'une au moins, le piment, connaîtra un succès extraordinaire, et à quelques cas d'acculturation par conversion au catholicisme parmi les populations côtières (les seules conversions massives concernent les Philippines espagnoles). La connexion entre Europe et Asie demeura donc quantitativement limitée, et discontinue, dans l'espace comme dans le temps — ce jusque dans la période de la colonisation à grande échelle. Entre un Bengale soumis à deux siècles de domination britannique, et certaines îles extérieures de l'archipel indonésien qui connurent tout juste quarante années de règne hollandais, il n'y a pas de commune mesure. Certaines zones virent leur structure productive totalement remaniée par le développement d'une agriculture de plantation : c'est le cas des Moluques méridionales (clou de girofle, noix muscade), de l'Assam et du haut pays de Ceylan (thé), d'une partie de la Malaisie (caoutchouc, palmier à huile), de certaines îles des Philippines (canne à sucre), des hautes terres de Java-Ouest (café). Le développement des plantations s'accompagna de mouvements massifs de main-d'œuvre, de l'Inde centrale vers l'Assam, du Tamilnad vers Ceylan et la Malaisie, de Java vers l' _Oostkust_ de Sumatra, ou du Tonkin vers la Cochinchine. La colonisation signifiait là un bouleversement complet, de nature révolutionnaire. Mais dans de bien plus vastes zones, elle se traduisit par un simple remaniement de structures d'extraction fiscale déjà en place, dont le poids sur les paysanneries s'accrut dans des proportions variables, suivant les lieux et les époques. Ce fut le cas dans la plupart des régions de l'Inde. Si la commercialisation de l'agriculture progressa sans doute globalement, l'essentiel de la production agricole restait destiné à l'autoconsommation paysanne. On ajoutera que dans les zones de montagnes et de grandes forêts, certes peu peuplées, mais couvrant ensemble plusieurs millions de kilomètres carrés, l'ordre étatique de la colonisation ne parvint généralement guère mieux à s'imposer que, précédemment, celui des États antérieurs à cette nouvelle période qui s'ouvrait. Ces populations très diverses, pratiquant l'agriculture sur brûlis, restaient autonomes _de facto_ , recevant tout juste, de temps à autre, la visite d'un explorateur, d'un missionnaire ou d'un ethnographe. L'effet en retour de l'intrusion des Européens en Asie méridionale fut pour sa part moins mesuré qu'on ne le croit généralement. La découverte de sociétés policées n'ayant pas connu la révélation chrétienne contribua au bouleversement des idées qui caractérisa la Renaissance. Par ailleurs, les voyages aidèrent au développement de nouveaux savoirs linguistiques, cartographiques et botaniques en particulier. La compilation du _Hortus Malabaricus Indicus_, réalisée au Kerala à la demande d'un gouverneur hollandais, servit de matériau à Linné pour sa classification des plantes. Outre les épices, déjà familières des tables européennes au moins depuis le XIIe siècle, arrivèrent aussi en Europe les objets divers, aux formes parfois extravagantes, qui remplirent les cabinets de curiosités (comme la collection des Médicis à Florence), ainsi que les animaux « exotiques », comme les éléphants ou les rhinocéros, qui inspirèrent les artistes de la Renaissance, un Dürer ou un Raphaël. L'imaginaire européen fut grandement stimulé par ce contact avec l'Asie méridionale. Mais celle-ci était aussi une grande puissance économique, dont l'expansion dut beaucoup aux navires d'Occident. À partir de la fin du XVIIe siècle, affluèrent en Europe les « indiennes », ou « calicots » (de Calicut), les tissus de coton fabriqués en Inde, utilisés d'abord surtout pour l'ameublement et la décoration. Certains fabricants européens songèrent à mixer coton et lin pour produire des « futaines », faisant ainsi pénétrer les tissus de coton dans le domaine de l'habillement en Europe. À la fin du XVIIe siècle, un directeur de l'East India Company eut l'idée de faire fabriquer en Inde deux cent mille pièces de tissus pour le marché européen, introduisant ainsi le « prêt-à-porter » dans la mode vestimentaire. L'Asie méridionale, entrée d'abord dans les demeures des Européens, commença à parer leurs corps. Les conséquences à long terme pour les économies européenne et asiatique furent considérables. Tandis qu'au XVIIIe siècle la mode des indiennes se répandait à travers toute l'Europe, les fabricants européens, incapables de reproduire la qualité des produits indiens, du fait de la supériorité des Indiens en matière de teinture, tentèrent de se protéger de la concurrence par des mesures douanières. Mais, ne réussissant pas à exclure totalement les indiennes du marché, ils choisirent la voie de la substitution d'importations en développant l'innovation technologique, avec la _spinning Jenny_ , puis le métier d'Arkwright, qui leur permirent d'abaisser leurs coûts et de devenir enfin compétitifs. Ainsi peut-on estimer que l'afflux des textiles indiens en Europe fut largement à l'origine de la révolution industrielle. En outre, suivant l'hypothèse peut-être osée d'A. R. T. Kemasang, l'amélioration de l'état de santé et de la capacité de travail par temps froid liée depuis les premières décennies du XVIIIe siècle en Grande-Bretagne à la consommation massive de thé aurait permis un important accroissement de la productivité. Ceci va en tout cas à l'encontre des idées reçues sur l'avance de l'Europe. Écrire une histoire connectée devient à la fois plus simple et plus complexe lorsqu'on aborde la période de domination colonial
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We think this is really going to change the way you can use the cloud in a lot of ways. With the release of the new model, you can deploy, manage and monitor related services in a resource group. Resource Manager enables deploying complex applications using templates, configures virtual machines using VM extensions, and incorporates access management and tagging. It also includes scalable, parallel deployment for virtual machines into availability sets. In addition, the new model provides lifecycle management of Compute, Network and Storage independently. And there’s a focus of enabling security by default with the enforcement of virtual machines in a Virtual Network. From a feature standpoint, almost all the features are supported for compute, network and storage under Azure Resource Manager with a few exceptions while we've added the ability to create scalable deployments using Virtual Machine Scale Sets. In addition, we are continuously improving the user experience and adding more features to the azure portal to bridge the experiences. Because of this new capability and growing deployment base in the Resource Manager model, we want to enable customers to be able to migrate existing deployments in Classic. Migration of IaaS resources from Classic to Resource Manager Stack The following articles take you through a step-by-step workflows of how to plan the migration and go through the entire process of moving your deployments into the resource manager model. PowerShell community scripts to clone Virtual Machines In addition to offering the platform service in public preview, we’re also releasing community-based PowerShell scripts that allow you to clone the virtual machines from the Classic to Resource Manager Stack. We are also accepting community contributions on the script repository. Next steps We will continually add more features and capabilities to the migration service in an effort to simplify your experience. In the meantime, hope to receive your feedback on the migration experience. Alternatively, you can also comment in our technical articles.Adolescent resilience: an evolutionary concept analysis. Resilience is a concept that has enormous utility in nursing, although there is a need for concept clarity as it relates to adolescence. The purpose of this article is to describe the concept and apply the Evolutionary Model of Concept Analysis to resilience in adolescents. A literature search and an analysis of 22 articles specific to the adolescent population were completed. The literature review revealed adolescent resilience to be a composite of attributes that include the characteristics of the adolescent, sources of social support, and available resources. Implications for nursing and a proposed model of adolescent resilience are presented.Jamie_Harris “Both WASR and UF spent a significant amount of time on academic outreach in 2018” I hadn’t realised this; I thought that Animal Ethics focused more on this, while WASR focused more directly on foundational research. Do you think there will be overloaded between WAI and Animal Ethics or do the organisations have different approaches? Yes, I had thought about this. There was a question in the survey intending to check if people thought this was the case so far, and I didn’t see much evidence for it. But Id guess that those sorts of effects might be less obviously noticeable, or might take longer to become noticeable. “For example, the difference between assigning a 5% probability and a 50% probability is epistemically vast but arguably practically insignificant. It merely affects the amount of expected value represented by invertebrates by one order of magnitude. There are very roughly 10^18 insects in the world, and this number is still multiple orders of magnitude higher than the number of vertebrate animals.” Given this point, and the implications of Jacy’s comment, perhaps it would be preferable to conceptualise the impact of this research/career plan in this area as a form of advocacy, rather than as a form of enhancing our knowledge and affecting cause prioritisation? In some ways, your rough career trajectory might look similar, but it might affect some decisions e.g. how to split your time between focusing on further research and focusing on giving talks to EA groups, academic settings etc. This list has research questions across a number of different themes or categories, e.g. “wider understanding of current animal use” and “evaluations of farmed animal interventions.” To think about which questions are important, I’d suggest categorising the questions, then prioritising the overall categories. Sentience Institute has summarised foundational questions in effective animal advocacy, and we tend to prioritise research that we think will best help to improve our understanding of these questions (see our research agenda). Frankly, there are huge amounts of research questions that could be useful in some shape or form to effective animal advocacy. I’m not aware of anyone having compiled a comprehensive list, although I think that this might be worthwhile doing at some point, especially to coordinate the different organisations and individuals conducting research and to avoid unnecessary duplication of effort. There are also important considerations about the risk that rainforest preservation efforts might indirectly increase suffering. Many in the effective altruism community believe that a large proportion of wild animals, especially invertebrates and other r-selected species, have net negative lives. Recently, this was the conclusion of a recent report by charity entrepreneurship. If you believe that there is a non-trivial chance that these animals can suffer or have morally relevant experiences, then the short- and medium-term effect of rainforest protection might be a counterfactual increase in wild animal suffering (see here for Brian Tomasik’s discussion of a related question). More widely, encouraging concern for habitat protection might encourage people to value non-sentient entities even where the interests of these non-sentient entities conflict with the direct interests of individual animals. In general, this seems to be a step in the wrong direction if you agree that moral circle expansion is desirable. This might encourage the likelihood of future dystopian scenarios which involve astronomical levels of suffering. In a sense, by promoting environmentalism via conservation, you might be reducing the chance of a global catastrophe via climat change but in
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Choosing the most effective antibody therapy to combine with first-line chemotherapy remains an important consideration, but the data informing this choice is conflicting. Traditional meta-analyses are helpful in providing a direct comparison between trials with the same intervention and comparator. However, in settings when few or no direct comparisons of treatments exist, an indirect comparison approach \[[@pone.0140187.ref022]\] allows for the comparison of treatments between groups from different trials, if the studies have a common treatment parameter \[[@pone.0140187.ref023],[@pone.0140187.ref024]\]. The use of a network meta-analysis (NMA) by combining direct evidence with indirect evidence can often increase the precision of the comparison \[[@pone.0140187.ref025]\]. NMAs have been recently conducted in a number of oncology settings including metastatic breast cancer \[[@pone.0140187.ref026]\], metastatic pancreatic cancer \[[@pone.0140187.ref027]\], adjuvant treatment for pancreatic cancer \[[@pone.0140187.ref028]\] and Hodgkins lymphoma \[[@pone.0140187.ref029]\] to simultaneously examine the relative efficacy of multiple treatments by synthesizing both direct and indirect evidence. In this study, we carried out a systematic review of all randomized controlled trials (RCTs) that compared systemic chemotherapy regimens with and without bevacizumab, cetuximab or panitumumab for the first-line treatment of mCRC and conducted both direct meta-analysis, and indirect and combined NMAs to assess the impact of these agents on PFS and OS. Methods {#sec006} ======= Search strategy and selection criteria {#sec007} -------------------------------------- We performed a systematic review to identify studies which examined the survival outcomes of mCRC patients. Under consideration for inclusion were all RCTs which compared chemotherapy treatment alone to either i) chemotherapy treatment in combination with BEV or ii) chemotherapy in combination with EGFRis. RCTs that directly compared chemotherapy treatment with EGFRis against chemotherapy combined with BEV were also considered. Studies were included regardless of the chemotherapy backbone as long as the backbone was identical in both the treatment and control arms. Studies were included only if the patients were being treated with first-line therapy for the treatment of mCRC. Those studies with more than two treatment arms were included if one of more of the arms included an eligible comparison; only arms addressing eligible comparisons were included in the analysis. For EGFRis trials, only data from K-RAS participants with wild-type K-RAS Exon 2 tumors was included. We excluded non-randomized trials, as well as trials involving non-metastatic colorectal cancer patients. Trials that included radiotherapy, hormonal therapy, gene therapy or other immunologic therapy in one of the arms were excluded. Studies with a comparison of chemotherapy and a VEGFi or an EGFRi against no treatment (best supportive care), or against a VEGFi or EGFRi alone were excluded. When several reports discussed the same trial, the report with the most recent data was included. We searched Medline, Embase, and the Central Registry of Controlled Trials of the Cochrane Library. All databases were updated through to the second week of September, 2014. We did not place any language restrictions on the search. The complete search strategy employed has been provided ([S1 Text](#pone.0140187.s009){ref-type="supplementary-material"}). Our review has been reported using the PRISMA reporting guidelines ([S1 PRISMA Checklist](#pone.0140187.s008){ref-type="supplementary-material"}). Data extraction {#sec008} --------------- Data was extracted by two independent reviewers with discrepancies between the reviewers discussed prior to selecting trials for inclusion in the systematic review and prior to inclusion in the meta-analysis. Unresolved discrepencies were reviewed by a third reviewer. We recorded primary author, trial ID, treatment comparison, primary and secondary outcomes studied, location of the trial, recruitment period, number of patients randomized and evaluated in each treatment arm, age, gender, and K-RAS status. The studies were organized into three treatment groups; chemotherapy with BEV against chemotherapy alone, chemotherapy with an EGFRi against chemotherapy alone, and chemotherapy with BEV against chemotherapy with an EGFRi. For our analysis, studies examining cetuximab or panitumumab were grouped together as EGFRi. Studies with different chemotherapy backbones, methods of chemotherapy administration, or methods of antibody therapy administration were grouped according to the type of antibody therapy used. In trials involving a comparison with an EGFRi, only data pertaining to wild-type K-RAS Exon 2 patients was extracted. For each trial, we recorded PFS and/or OS of the treatment and control arms, the hazard ratio (HR), log-rank p-value, and confidence intervals when available. In studies where the HR, p-value, or confidence intervals were not provided, it was calculated from the log-rank p value, the number of events in each arm and the number of randomized patients in each arm using the Parmar method \[[@pone.0140187.ref030]\]. Statistical analysis {#sec009} -------------------- Pairwise meta-analyses were conducted to examine treatment regimens that were directly compared in the studies; chemotherapy vs chemotherapy with EGFRis, chemotherapy vs chemotherapy with BEV, and EGFRis vs BEV with chemotherapy in both arms. The results were combined into forest plots using Review Manager, version 5.2, using the random-effects model. To assess the comparability of included studies, between-study heterogeneity was estimated and reported using the I^2^ statistic; the value of I^2^ lies between 0% and 100%, where 0% indicates no observed heterogeneity and larger values show increasing heterogeneity \[[@pone.0140187.ref031]\]. We conducted a Bayesian NMA to examine the indirect comparison of EGFRis vs. BEV through the intermediate treatment of chemotherapy alone, and to combine the indirect comparison with the direct comparison, using WinBUGS, version 1.4.3. A detailed explanation of the statistical method \[[@pone.0140187.ref032]\] employed for the NMA has been provided ([S2 Text](#pone.0140187.s010){ref-type="supplementary-material"}). Bayesian NMAs were performed at three time points, which included: i) trials published prior to the FIRE-3 trial, \[[@pone.0140187.ref019]\] ii) trials up to and including FIRE-3, and iii) all trials published up to and including the CALGB 80405 trial \[[@pone.0140187.ref020]\], which was the last trial found by the literature search. In addition, a Bayesian NMA was conducted for all trials excluding FIRE-3. Sensitivity analyses were conducted to explore the effect of adjusting for the types of chemotherapy backbone (oxaliplatin-based, irinotecan-based or fluoropyrimidines alone) and the mode of fluoropyrimidines delivery (bolus or infusional). This was performed by including those effects as covariates in the meta-regression of the Bayesian NMA. The results were presented according to the guidelines of the Quality of Reporting of Meta-analyses (QUOROM) and International Society for Pharmacoeconomics and Outcomes Research (ISPOR) \[[@pone.0140187.ref033],[@pone.0140187.ref034]\]. Results {#sec010} ======= Literature Search Results {#sec011} ------------------------- Our electronic search of Medline, Embase and the Cochrane Central Register of Controlled Trials databases yielded 2435 potentially relevant articles. Our manual search through the 2013 and 2014 ASCO General Meeting abstracts produced an additional 62 results. Following a deletion of duplicate results from different databases, there were 1581 records. Ultimately, we identified 17 unique studies for inclusion in the meta-analysis, including 2 ASCO abstracts ([Fig 1](#pone.0140187.g001){ref-type="fig"}). [Fig 2](#pone.0140187.g002){ref-type="fig"} shows the network of available treatment comparisons, along with the number of times each comparison was made in a study. ![PRISMA flow diagram of included and excluded trials identified from the literature search.](pone.0140187.g001){#pone.0140187.g001} ![Network of treatment comparisons.\ The numbers represent the number of studies providing the comparison between the treatment regimens. The solid and dashed lines represent direct and indirect treatment comparisons of studies included in our analysis, respectively.](pone.0140187.g002){#pone.0140187.g002} Study Quality {#sec012} ------------- The quality of studies included in the NMA was evaluated using the Cochrane risk of bias tool \[[@pone.0140187.ref035]\]. A list of biases was summarized ([S1](#pone.0140187.s001){ref-type="supplementary-material"} and [S2](#pone.0140187.s002){ref-type="supplementary-material"} Figs). Publication bias was evaluated by constructing funnel plots for the studies included in each direct comparison for OS ([S3 Fig](#pone.0140187.s003){ref-type="supplementary-material"}). The three plots for OS were all symmetrical and show no evidence of publication bias. All included studies were randomized and followed intention-to-treat analysis for the primary endpoints (PFS and OS). Two of the studies (CALGB 80405, ITACA) were published only in abstract form, and we were unable to judge whether selection, allocation, assessment, attrition and/or reporting bias were present. All of the trials reported median PFS, and all except for one (Kabbinavar et al, 2003), provided extractable data for OS
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575, 1449, 283, 2537, 17605, 313, 1229, 15, 24, 10, 3677, 313, 1423, 15, 1237, 10, 28899, 313, 1619, 15, 1762, 10, 575, 1235, 283, 3046, 28899, 313, 3156, 10, 12347, 313, 1610, 15, 4196, 10, 23850, 313, 1839, 15, 25, 10, 575, 1549, 283, 2090, 16198, 313, 1423, 15, 24, 10, 2222, 313, 1717, 15, 2597, 10, 21451, 313, 1099, 10, 575, 1967, 283, 1976, 1839, 313, 22, 15, 22, 10, 2031, 313, 1012, 15, 25, 10, 3507, 313, 25, 15, 1036, 10, 575, 12515, 2363, 3011, 15, 25, 14808, 3069, 14808, 26, 15, 46027, 15, 21, 14808, 3069, 14808, 25, 15, 25320, 15, 22, 14808, 3069, 14808, 26, 40702, 40702, 30456, 3473, 575, 17151, 8292, 2452, 32960, 313, 3680, 15, 18, 10, 20210, 313, 3655, 15, 23, 10, 35216, 313, 2526, 10, 575, 52, 9207, 3422, 2614, 3473, 14380, 15, 23, 14808, 3069, 14808, 1012, 15, 25, 15220, 15, 21, 14808, 3069, 14808, 1012, 15, 25, 15468, 15, 21, 575, 12558, 28013, 2614, 3473, 3547, 15, 17, 14808, 3069, 14808, 26, 15, 49310, 15, 25, 14808, 3069, 14808, 26, 15, 31408, 15, 19, 575, 15163, 2280, 3605, 1610, 15, 17, 14808, 3069, 14808, 24, 15, 18348, 15, 26, 14808, 3069, 14808, 23, 15, 49268, 15, 520, 40702, 40702, 42902, 301, 6222, 313, 7913, 16, 21087, 10, 575, 12481, 13559, 11395, 15, 22, 14808, 3069, 14808, 1449, 15, 520, 2691, 15, 17, 14808, 3069, 14808, 1671, 15, 520, 2759, 15, 19, 575, 44139, 13559, 1867, 15, 25, 14808, 3069, 14808, 25, 15, 40948, 15, 24, 14808, 3069, 14808, 25, 15, 24, 3079, 15, 25, 575, 44004, 13559, 7749, 15, 22, 14808, 3069, 14808, 1706, 15, 24, 14322, 15, 20, 14808, 3069, 14808, 2405, 15, 3156, 805, 15, 20, 575, 16854, 13559, 2082, 15, 26, 14808, 3069, 14808, 2405, 15, 26422, 15, 24, 14808, 3069, 14808, 1731, 15, 36630, 10605, 10470, 746, 313, 19, 15, 25, 10, 3583, 313, 1036, 15, 21, 10, 3677, 313, 24, 15, 3071, 10, 12558, 24298, 27000, 22341, 313, 2082, 15, 22, 10, 17306, 313, 1706, 15, 22, 10, 36043, 313, 2950, 15, 18, 10, 1785, 32177, 3270, 41537, 3134, 1971, 35630, 313, 3677, 15, 25, 10, 18121, 313, 1619, 15, 19, 10, 22, 2787, 313, 3011, 15, 24, 10, 1785, 32177, 1098, 249, 28333, 313, 2251, 10, 14009, 313, 2082, 15, 24, 10, 19807, 313, 2526, 15, 22, 10, 3378, 13440, 2728, 19105, 313, 1731, 15, 24, 10, 14840, 313, 2417, 10, 24454, 313, 1671, 15, 24, 10, 5180, 18, 48167, 19, 62, 187, 187, 20, 15, 19, 15, 23736, 273, 253, 767, 9600, 1712, 84, 31253, 94, 187, 35000, 187, 187, 23648, 273, 26281, 281, 1098, 249, 4918, 1754, 327, 253, 767, 9600, 310, 2011, 275, 544, 3235, 374, 1084, 85, 17553, 910, 709, 14, 881, 568, 2420, 7129, 10635, 327, 253, 14809, 6490, 29609, 13, 627, 497, 15470, 5086, 313, 3079, 15, 24, 2673, 285, 29226, 5343, 1363, 313, 1449, 15, 23, 2673, 13410, 281, 4763, 1098, 249, 4918, 15, 380, 2264, 1180, 323, 5207, 1971, 369, 8521, 310, 38627, 313, 3156, 15, 23, 10970, 3235, 374, 40189, 12645, 1754, 327, 20413, 16, 34, 10114, 9600, 347, 2429, 281, 14809, 6490, 9600, 2796, 47, 11, 14808, 30, 14808, 38723, 481, 40189, 9050, 15804, 16, 34, 10114, 61, 187, 11, 47, 11, 11767, 25606, 6490, 61, 187, 11, 47, 11, 11767, 11, 81, 11, 60, 66, 1084, 12749, 4174, 18, 910, 709, 14, 881, 568, 2420, 14, 4174, 986, 40953, 1397, 4313, 323, 1971, 8521, 313, 39943, 7726, 10, 12481, 1180, 323, 5207, 1971, 310, 8521, 34384, 313, 2597, 15, 22, 10, 35833, 313, 3156, 15, 23, 48744, 17, 15, 5831, 26, 15, 25, 313, 24, 15, 25, 283, 805, 15, 20, 10, 40702, 40702, 39, 358, 2339, 2796, 47, 11, 14808, 30, 14808, 29868, 48744, 17, 15, 5831, 23, 15, 24, 313, 22, 15, 19, 283, 25, 15, 23, 10, 40189, 8521, 43995, 313, 3507, 15, 18, 10, 23163, 313, 1449, 15, 23, 10, 575, 12412, 7133, 8320, 313, 3680, 15, 19, 10, 1322, 575, 4120, 5034, 7133, 18467, 313, 1508, 15, 26, 10, 35649, 9048, 417, 8521, 10683, 313, 1166, 15, 26, 10, 22488, 313, 3046, 15, 20, 10, 40702, 40702, 46, 2339, 2796, 47, 11, 14808, 30, 14808, 28560, 48744, 17, 15, 5831, 13743, 15, 19, 313, 2945, 15, 22, 283, 34230, 15, 23, 10, 40189, 8521, 23580, 313, 1525, 15, 18, 10, 15270, 313, 3079, 15, 24, 10, 575, 12412, 7133, 19044, 313, 2222, 15, 17, 10, 1322, 575, 4120, 5034, 7133, 1012, 313, 21, 15, 18, 10, 35649, 9048, 417, 8521, 20, 313, 17, 15, 26, 10, 17864, 313, 3208, 15, 20, 10, 5180, 20, 48167, 21, 62, 187, 187, 15545, 327, 253, 20413, 16, 34, 10114, 29609, 13, 1971, 369, 8521, 275, 29117, 10798, 313, 1525, 15, 18, 2673, 285, 45421, 10753, 313, 3507, 15, 18, 10970, 16257, 13, 247, 1029, 14, 38172, 1098, 249, 369, 8521, 275, 29044, 5086, 313, 2222, 2673, 285, 9166, 5343, 1363, 313, 3680, 15, 19, 10970, 17012, 369, 417, 8521, 275, 760, 1264, 5086, 1363, 313, 17, 15, 26, 2673, 285, 15567, 10753, 313, 1166, 15, 26, 2673, 2470, 3235, 374, 1084, 85, 17553, 910, 709, 14, 881, 568, 2420, 2536, 380, 2264, 1180, 273, 4292, 323, 5207, 1971, 369, 8521, 310, 854, 2787, 313, 2597, 15, 22, 481, 187, 187, 11888, 253, 20413, 16, 34, 10114, 29609, 13, 40137, 3081, 1363, 313, 1857, 15, 26, 2673, 651, 320, 13410, 323, 1098, 249, 4918, 15, 380, 2264, 1180, 273, 1363, 13410, 323, 1098, 249, 4918, 310, 374, 15, 18, 2069, 313, 34384, 16, 35833, 10, 326, 275, 253, 1711, 29609, 15, 380, 3064, 875, 253, 767, 9600, 369, 10126, 1534, 2470, 3235, 374, 1084, 85, 17553, 910, 709, 14, 881, 568, 2420, 2536, 380, 13653, 273, 46705, 247, 1098, 249, 1754, 327, 253, 20413, 16, 34, 10114, 310, 1199, 2169, 313, 36344, 884, 2069, 10, 2429, 281, 253, 14809, 6490, 29609, 2470, 3235, 374, 1084, 85, 17553, 910, 709, 14, 881, 568, 2420, 2536, 187, 187, 20, 15, 20, 15, 2006, 11724, 273, 14975, 281, 253, 3332, 20413, 16, 34, 10114, 1971, 29609, 1712, 84, 35173, 94, 187, 43067, 187, 187, 9083, 6876, 15588, 1098, 968, 275, 760, 47633, 313, 3121, 2673, 273, 253, 854, 2787, 13410, 1363, 15, 7214, 10677, 313, 740, 15, 22, 2673, 273, 253, 42444, 13410, 1363, 497, 15588, 1029, 14, 38172, 1098, 249, 15, 187, 187, 20, 15, 21, 15, 9052, 1761, 17888, 273, 1543, 281, 253, 16158, 3072, 1712, 84, 41545, 94, 187, 6154, 7040, 187, 187, 7992, 1761, 311, 839, 253, 1263, 1543, 281, 608, 15, 1036, 3041, 16158, 7747, 10652, 3387, 283, 1976, 14808, 10526, 13, 271, 5998, 374, 15, 16607, 3041, 7747, 313, 3156, 15, 23, 6, 273, 1110, 10652, 3387, 283, 1976, 14808, 10526, 13, 285, 884, 15, 20, 6, 273, 253, 1384, 15, 25, 3041, 16158, 3072, 275, 4104, 10, 651, 320, 13410, 281, 4763, 1098, 249, 4918, 13, 2556, 281, 253, 6752, 14809, 6490, 29609, 15, 496, 4499, 13, 253, 5998, 1180, 273, 1098, 249, 4212, 651, 320, 11848, 281, 577, 15, 40666, 3041, 313, 2597, 15, 22, 6, 273, 1110, 3387, 283, 1976, 14808, 10526, 273, 2363, 13, 285, 3127, 15, 24, 6, 273, 253, 1384, 15, 25, 3041, 16158, 3072, 275, 4104, 10, 2556, 281, 253, 20413, 16, 34, 10114, 29609, 15, 15699, 13, 374, 15, 26673, 3041, 3081, 16158, 1363, 651, 320, 13410, 323, 1098, 249, 4918, 672, 9433, 253, 20413, 16, 34, 10114, 29609, 15, 187, 187, 20, 15, 22, 15, 12805, 12739, 273, 9433, 253, 20413, 16, 34, 10114, 1971, 29609, 1712, 84, 42834, 94, 187, 2518, 283, 187, 187, 510, 2105, 12739, 273, 9433, 253, 20413, 16, 34, 10114, 1971, 29609, 403, 12800, 275, 544, 3235, 495, 1084, 85, 22140, 910, 709, 14, 881, 568, 2420, 7129, 380, 2105, 273, 1098, 968, 897, 651, 320, 2559, 407, 9199, 6, 672, 9433, 253, 747, 29609, 15, 9052, 1761, 311, 839, 253, 906, 281, 253, 2862, 16158, 3072, 13, 9433, 253, 747, 29609, 651, 906, 275, 247, 2105, 2572, 273, 387, 1878, 577, 15, 28560, 6494, 12938, 591, 807, 15, 3235, 495, 25997, 12739, 273, 9433, 253, 20413, 16, 34, 10114, 1971, 29609, 4681, 66, 1084, 12749, 4174, 19, 910, 709, 14, 881, 568, 2420, 14, 4174, 986, 998, 5009, 25997, 1754, 327, 14809, 6490, 29609, 591, 807, 61, 187, 9672, 79, 11, 14808, 30, 14808, 35833, 562, 273, 2233, 22, 10, 25997, 1754, 327, 20413, 16, 34, 10114, 61, 187, 38246, 4115, 591, 807, 61, 187, 9672, 79, 11, 14808, 30, 14808, 34384, 562, 273, 2233, 22, 10, 25800, 511, 275, 2105, 591, 807, 672, 9433, 61, 187, 15804, 16, 34, 10114, 29609, 25997, 2572, 591, 807, 672, 9433, 20413, 16, 34, 10114, 29609, 26480, 35631, 281, 512, 16158, 1363, 10652, 3387, 283, 1976, 340, 61, 187, 9, 1542, 3081, 374, 15, 26673, 3041, 1363, 10, 2042, 512, 13410, 1363, 2959, 2058, 263, 35982, 5009, 3387, 14808, 7913, 40187, 13, 48180, 12938, 18, 13, 31459, 13 ]	aged 40--75 years have similar demographic characteristics as those in the study sample. The percentage of Saudi citizens aged 40--75 years who would be eligible for statins therapy based on the ATP III guideline and the ACC/AHA guidelines was calculated based on the results obtained from the study sample. In April 2015, there were 5.16 million Saudi adults aged 40--75 years, and the total number of the Saudi population was 20.8 million. 2.6. Cost implications of applying the ACC/AHA treatment guideline {#s0040} ------------------------------------------------------------------ The cost implication of applying the ACC/AHA treatment guideline was based on the average cost of 40 mg atorvastatin in the Saudi market. Atorvastatin was selected because it is the most commonly prescribed statins. The cost of a 40 mg tablet was selected as most patients would be eligible for high-intensity statin therapy, which is defined as an atorvastatin dose of 40--80 mg/d. The average cost of 30 tablets of 40 mg atorvastatin in the Saudi market was 151.9 Saudi Riyal (SR) (based on the price of 8 different products). The average cost per patient per year would be 1822.8 SR. One Saudi riyal equals US\$0.27. 3. Results {#s0045} ========== 3.1. Study sample {#s0050} ----------------- A total of 1200 patients were randomly selected from the database of 30,876 eligible patients aged 40--75 years. One hundred and ninety-five patients were excluded from the analysis because of missing lipid profile data. Baseline characteristics of the study patients (1005 patients) are presented in [Table 1](#t0005){ref-type="table"}. The mean age of the sample was 55.4 years (standard deviation = 9 years). Females represented 68.4% of the sample. Among the study participants, there were 359 (35.7%) patients who had a history of CVD. The average age for the study population (age 40--75 years) was similar to that of the randomly selected sample (55.9 years vs. 55.4 years). The sex distribution of the study population was also similar to that of the study sample (females: 67.2% vs. 68.4% of the study sample).Table 1Demographic and clinical characteristics of the study population.VariableFemalesMalesTotalN (%)687 (68.4)318 (31.6)1005 (100)  Age (y) 40--49211 (30.7)71 (22.32)282 (28.05) 50--59282 (41)108 (33.96)390 (38.8) 60--69156 (22.7)95 (29.87)251 (25) 70--7538 (5.5)44 (13.8)82 (8.16) Mean age57.8 ± 9.554.4 ± 8.655.5 ± 9  Blood pressure Hypertension399 (58.1)234 (73.6)663 (66) Systolic blood pressure133.6 ± 13.8136.4 ± 13.8134.4 Diastolic blood pressure72.0 ± 9.775.8 ± 9.473.2 Body mass index33.0 ± 7.029.9 ± 6.632.01  Lipid profile (mg/dL) Total cholesterol180.5 ± 40.0186.0 ± 35.0184.2 HDL cholesterol39.8 ± 8.445.7 ± 8.743.8 LDL cholesterol110.5 ± 34.7113.3 ± 31.4112.3 TG cholesterol65.9 ± 31.358.7 ± 26.661Current smoking19 (2.8)52 (16.4)71 (7.06)Diabetes mellitus355 (65.5)187 (34.5)463 (46.1)Receiving antihypertensive treatment416 (71.8)163 (28.2)579 (57.7)Receiving statin459 (67)209 (65.7)668 (66.5)With cardiovascular disease184 (26.7)175 (55)359 (35.7)[^1][^2] 3.2. Comparison of the two guidelines {#s0055} ------------------------------------- Comparison of eligibility to statin therapy based on the two guidelines is shown in [Table 2](#t0010){ref-type="table"}. Based on the ATP III guideline, there were 139 male (43.7%) and 279 female patients (40.6%) eligible to receive statin therapy. The total number for whom treatment was recommended is 418 (41.6%).Table 2Treatment recommendations based on ACC/AHA guidelines as compared to ATP III guidelines (N = 1005).Treatment categoriesACC/AHA\ N (%)ATP III\ N (%)p[a](#tblfn1){ref-type="table-fn"}Odds ratio for treatment recommended (confidence interval)Total number for whom treatment is recommended879 (87.5)418 (41.6)\<0.00019.8 (7.8--12.3)  Females (N = 687)\<0.00016.7 (5.2--8.6)Treatment recommended564 (82.1)279 (40.6) High intensity400 (58.2)NA Moderate intensity164 (23.9)NATreatment not recommended123 (17.9)408 (59.3)  Males (N = 318)\<0.0001135.2 (42.5--430.6)Treatment recommended315 (99.1)139 (43.7) High intensity302 (95.0)NA Moderate intensity13 (4.1)NATreatment not recommended3 (0.9)179 (56.3)[^3][^4] Based on the ACC/AHA guideline, treatment was recommended in 315 males (99.1%) and 564 females (82.1%). Meanwhile, a high-intensity statin was recommended in 302 male (95%) and 400 female patients (58.2%). Treatment was not recommended in only three male patients (0.9%) and 123 females (17.9%) ([Table 2](#t0010){ref-type="table"}). The total number of individuals for whom treatment was recommended is 879 (87.5). Using the ACC/AHA guideline, 461 additional patients (45.9%) would be eligible for statin therapy. The total number of patients eligible for statin therapy is 2.1 times (879/418) that in the old guideline. The difference between the two guidelines was statistically significant ([Table 2](#t0010){ref-type="table"}). The odds of recommending a statin based on the ACC/AHA is much higher (approximately 10 times) compared to the ATP III guideline ([Table 2](#t0010){ref-type="table"}). 3.3. Adherence of physicians to the recent ACC/AHA treatment guideline {#s0060} ---------------------------------------------------------------------- Physician prescribed statins in only 668 (76%) of the 879 eligible patients. Only 74 (10.5%) of the 702 eligible patients were prescribed high-intensity statin. 3.4. Extrapolation of results to the Saudi population {#s0065} ----------------------------------------------------- Extrapolating the study results to 5.16 million Saudi adults aged 40--75 years, an estimated 2.146 million adults (41.6% of those aged 40--75 years, and 10.3% of the 20.8 million Saudi population in 2015) would be eligible to receive statin therapy, according to the 2002 ATP III guideline. In contrast, the estimated number of statin users would be expanded to 4.515 million (87.5% of those 40--75 years of age, and 21.7% of the 20.8 million Saudi population in 2015) according to the ACC/AHA guideline. Overall, 2.369 million additional Saudi patients would be eligible for statin therapy when applying the ACC/AHA guideline. 3.5. Cost implications of applying the ACC/AHA treatment guideline {#s0070} ------------------------------------------------------------------ The cost implications of applying the ACC/AHA treatment guideline are illustrated in [Table 3](#t0015){ref-type="table"}. The cost of statins use would be increased by 110% when applying the new guideline. Extrapolating the result to the entire Saudi population, applying the new guideline would result in a cost increase of at least 4.318 billion SR per year.Table 3Cost implications of applying the ACC/AHA treatment guideline.[a](#tblfn2){ref-type="table-fn"}StatinCost based on ATP III guideline per year\ (n = 418 out of 1005)Cost based on ACC/AHA\ guideline per year\ (n = 879 out of 1005)Increase in cost per year when applying\ ACC/AHA guidelineCost increase per year when applying ACC/AHA guideline extrapolated to all Saudi patients aged 40--75 y\ (for additional 2.369 million patients)If all eligible patients received Atorvastatin 40 mg761,930 SR1,602,
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2042, 309, 497, 253, 4651, 273, 247, 5816, 1429, 13, 642, 2647, 752, 2363, 13, 285, 309, 369, 12470, 281, 247, 2201, 3668, 2086, 281, 19494, 323, 521, 4999, 1091, 760, 281, 452, 253, 8223, 13444, 13, 309, 1871, 320, 39309, 745, 1512, 15, 733, 434, 10458, 281, 13387, 253, 21009, 257, 17638, 323, 616, 3879, 13, 3782, 342, 247, 5816, 1429, 15 ]	Last Modified: Monday, January 28, 2013 at 11:16 p.m. I am a husband, father, grandfather, local business owner, deacon in my local church and a gun owner/collector. I own an AR-15 style assault rifle along with several other style rifles, pistols and shotguns. I enjoy the sport of shooting and hunting. I am not a threat to society, but do exercise my constitutional right to keep and bear arms. — Tuscaloosa Kudos to Chris Beasley of Northport for his letter to the editor on Dec. 31. He 100 percent nailed it. All the gun laws they could pass would not keep a criminal from obtaining guns, nor keep him from committing a crime. All it would do is make the honest, law-abiding person more vulnerable to the criminal element. <p>I am a husband, father, grandfather, local business owner, deacon in my local church and a gun owner/collector. I own an AR-15 style assault rifle along with several other style rifles, pistols and shotguns. I enjoy the sport of shooting and hunting. I am not a threat to society, but do exercise my constitutional right to keep and bear arms. </p><p>— Tuscaloosa</p><p>Kudos to Chris Beasley of Northport for his letter to the editor on Dec. 31. He 100 percent nailed it. All the gun laws they could pass would not keep a criminal from obtaining guns, nor keep him from committing a crime. All it would do is make the honest, law-abiding person more vulnerable to the criminal element.</p><p>— Berry</p>F-15s begin leaving Montana Guard base Jun. 19, 2013 - 04:24PM \| GREAT FALLS, MONT. — The first of 20 F-15 fighter jets assigned to the Montana Air National Guard has left Great Falls for Fresno, Calif., as the 120th Fighter Wing begins changing its mission. One fighter left Tuesday, four more are scheduled to leave over the next few weeks and seven more will move in September. The final eight will move around October, said Col. Pete Hronek, 120th commander. Equipment related to the F-15s is also being moved to California. MANG also is preparing for eight C-130 cargo planes that are expected to start arriving this fall. Hronek told the Great Falls Tribune that an environmental assessment needs to be completed, crew members need training and some construction needs to be done. The Pentagon has estimated the total cost of the transition at about $48 million, plus construction costs, but Hronek said it could be higher because of training costs. About half of the MANG pilots are leaving the unit to keep flying F-15s or F-16s, said Col. Shane Sanders, operations group commander at the 120th. The unit will be down to 14 pilots but will need about 40 for the C-130 mission. That means the unit will hire pilots over the next few years as well as other flight crew positions such as co-pilot, navigator and loadmaster. Some F-15 pilots will undergo the seven months of training needed to fly a C-130, Sanders said. The transition marks the end of 66 years of flying fighter aircraft in Great Falls.// // InfiniteScrollingHelpView.h // AppDevKit // // Created by Chih Feng Sung on 12/7/15. // Copyright © 2015, Yahoo Inc. // Licensed under the terms of the BSD License. // Please see the LICENSE file in the project root for terms. // #import "PullToRefreshHelpView.h" @interface InfiniteScrollingHelpView : PullToRefreshHelpView <ADKPullToRefreshViewProtocol, ADKInfiniteScrollingViewProtocol> @end Was Libyan dictator Muammar Gaddafi the richest person of all time when he died back in October? New evidence has come to light recently that shows Muammar Gaddafi may have had a personal net worth north of $200 billion. This net worth would have made Gaddafi the richest human in the world by a long shot and perhaps the richest person to have ever lived in history. $200 billion is more than three times the net worth of the current richest person in the world Mexican tele-com tycoon Carlos Slim. It would be four times as much as Warren Buffet. So how did Muammar Gaddafi create such a massive personal fortune? Pretty sure it wasn't from hard work and penny pinching… Related Link: Muammar Gaddafi Net Worth Muammar Gaddafi was able to build his massive personal wealth thanks to a violent and domineering control over Libya's natural resources. Specifically their rich supply of oil. Libya has the largest supply of oil in Africa and the tenth largest in the world. Gaddafi used Libya's oil to print money for 40 years! During that time he spread his money around the globe through family members, Swiss bank accounts, real estate and investments. Estimated at $200 billion, he had enough to give $30,000 to each of Libya's 6.6 million citizens. At the beginning of the Lybian conflict, authorities discovered and seized roughly $67 billion of Gaddafi's wealth hidden in bank accounts around the globe. England, France, Italy and Germany seized another $30 billion and the Obama administration found a staggering $37 billion in the United States. Investigators suspect that Gaddafi hid an additional $30 billion around the world. As more investigations take place, it looks like Gaddafi had money stashed or invested in almost every major country in the world including the United States, Europe, the Middle East and Asia. In addition to bank accounts, Muammar owned a stake in the Italian soccer club Juventus and the car company Fiat. He also was a minority of London's Financial Times. Gaddafi had luxury homes around the world including the huge estate pictured below. Surprisingly this house is located in the United States. In Englewood, New Jersey of all places! His house includes a huge swimming pool, tennis court and even a shooting range… Investigators from U. N. Security are still waiting on many countries to resolve what Gaddafi might have within their borders. Several neighboring African nations refused to freeze Gaddafi's accounts because of their fear and loyalty to the ruthless leader. Now that he's dead, we should see even more money come to light. On top of all this, it's believed that Gaddafi had billions of dollars worth of gold hidden in Libya, which has yet to be discovered. Did Mummar Gaddafi's $200 billion make him the richest person of all time? To find out how he stacks up, click this article: The 25 Richest People Who Ever Lived – Inflation AdjustedIf it's snowing like crazy where you are, the best thing for you to do is sit back and listen to us talk about TV. This week, Jason Hughes and Bob Sassone join me to talk about what's going on in the TV world: More on the Winter Olympics and how bad NBC is messing them up, The latest way the network morning shows are scaring parents (it has to do with the site Chatroulette), The crazy first week of March on TV this year, How most of the pilot casting news you're hearing about right now isn't going to matter in a couple of months, How quickly the Andrew Koenig story spread from Twitter and Facebook to 'Larry King' and other national coverage (we taped this before Koenig's body was found yesterday), Vancouver police and the actor's father, Walter Koenig (best known for playing Lt. Chekov on the original 'Star Trek,' have confirmed the news. Later, during an emotional press conference, Walter Koenig acknowledged, "My son took his own life." For more on the story, visit Popeater.com. TMZ has a sad and heartbreaking update on the ongoing saga of Andrew Koenig. Police have found the actor's body and his father, Walter Koenig, said it appears that his son took his own life. Vancouver police released a statement earlier today that said a body was found in Stanley Park around noon that they believed was Koenig, the 41-year-old actor, activist and photographer who played Boner on the 80's sitcom 'Growing Pains'. Andrew's mother, Judy, and father have just offered a public statement. Through the tears, they thanked the people who reached out to the family and urged people who think they are suffering from depression to seek help through their friends and family. The parents of Andrew Koenig, best known for playing Richard "Boner" Stabone on the television series 'Growing Pains', walked off the set of 'Larry King Live' when their segment was interrupted by a breaking news story. Andrew's father is Walter Koenig, who is best known for playing the character of Pavel Chekov on the original 'Star Trek' series (and is only slightly less known for playing the evil telepath Alfred Bester on 'Babylon 5'). If I were the parents of a missing child, no matter what age, and I was invited to a major news program to plead for his safe return only to have the segment delayed, I'd be pissed off too. It's tough to blame the Koenigs for their behavior, particularly with a missing child.
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253, 9893, 13890, 1416, 27, 247, 9908, 323, 33707, 326, 403, 1160, 342, 247, 44064, 11847, 281, 3290, 15, 187, 187, 510, 572, 1143, 2586, 7773, 273, 5003, 443, 1528, 40635, 247, 418, 19283, 13, 275, 9972, 457, 84, 418, 1370, 900, 2919, 13, 369, 5769, 285, 17100, 9893, 13890, 457, 84, 4201, 5070, 15, 187, 187, 1147, 457, 84, 247, 23420, 7773, 326, 310, 1728, 281, 1142, 13723, 13, 14128, 285, 5101, 33179, 18014, 13, 533, 352, 369, 275, 253, 2919, 457, 84, 19033, 38828, 326, 253, 9893, 13890, 2021, 457, 84, 9908, 323, 8995, 3715, 15, 187, 187, 688, 6157, 13, 253, 9893, 13890, 457, 84, 7156, 273, 247, 2021, 14, 15280, 3330, 1771, 3395, 247, 6612, 672, 13, 2220, 253, 28677, 273, 30480, 1608, 324, 28287, 13, 253, 9893, 13890, 22301, 2867, 369, 9716, 1108, 329, 7346, 36982, 6389, 534, 20621, 84, 10520, 457, 84, 496, 1059, 13, 30480, 15, 12529, 265, 333, 285, 253, 45788, 31504, 1475, 22783, 15, 187, 187, 510, 2867, 369, 9288, 342, 247, 10020, 14, 11984, 3330, 1771, 534, 13, 342, 253, 2021, 457, 84, 9470, 5140, 285, 11369, 2793, 13, 369, 1996, 6312, 275, 5403, 15, 2726, 247, 2266, 11847, 281, 3290, 13, 253, 1735, 13265, 2607, 497, 5262, 8133, 2366 ]	must now accept the page load, as opposed to a seamless redirect, which is undesirable). Anyone have a solution to redirect to a custom url without some arbitrary path? Thanks. A: custom:// is not a URI. You must have something after that or otherwise it's not saying to go anywhere. Try going to http://. That work? No, it's not a URI. Same principle here. EDIT: Apple does some strange stuff so you have to do something with JavaScript. That is not actually a valid URI, Safari just detects it and launches the app. Pioneer, Ohio Pioneer is a village in Williams County, Ohio, United States. The population was 1,369 at the 2010 census. History Pioneer was platted in 1853. A post office has been in operation at Pioneer since 1851. From 1903, the village was the terminus of an electric interurban passenger railroad from Toledo called the Toledo and Western Railway, which was hoping to become a link in an electric rail service from that city to Chicago but which got no further. The line closed to passengers in 1933 but continued freight service until 1943, from 1934 as the Pioneer and Fayette Railroad. This was only formally abandoned in 1991. Geography Pioneer is located at (41.680569, -84.552796). According to the United States Census Bureau, the village has a total area of , of which is land and is water. Demographics As of 2000 the median income for a household in the village was $37,153, and the median income for a family was $46,369. Males had a median income of $32,917 versus $21,466 for females. The per capita income for the village was $18,024. About 5.9% of families and 6.5% of the population were below the poverty line, including 8.0% of those under age 18 and 5.3% of those age 65 or over. 2010 census As of the census of 2010, there were 1,380 people, 583 households, and 375 families residing in the village. The population density was . There were 653 housing units at an average density of . The racial makeup of the village was 96.3% White, 0.8% African American, 0.4% Native American, 0.1% Asian, 0.7% from other races, and 1.7% from two or more races. Hispanic or Latino of any race were 4.6% of the population. There were 583 households of which 32.6% had children under the age of 18 living with them, 45.8% were married couples living together, 11.8% had a female householder with no husband present, 6.7% had a male householder with no wife present, and 35.7% were non-families. 30.9% of all households were made up of individuals and 9.4% had someone living alone who was 65 years of age or older. The average household size was 2.37 and the average family size was 2.89. The median age in the village was 36.6 years. 25% of residents were under the age of 18; 9% were between the ages of 18 and 24; 25.6% were from 25 to 44; 26.7% were from 45 to 64; and 13.7% were 65 years of age or older. The gender makeup of the village was 48.7% male and 51.3% female. Connor Wheeler local SJW was deemed to be the most ignorant citizen in the history of Pioneer, Oh. Education North Central High School is renovated with a new high school in 2016 and is a public high school in Pioneer. A member of the Buckeye Border Conference, it is the only high school in the North Central Local Schools district. The school's sports teams are nicknamed the Eagles. Pioneer has a public library, a branch of the Williams County Public Library. References External links North Central Local Schools Chamber of commerce Category:Villages in Williams County, Ohio Category:Villages in OhioIncreased in vitro migration of human umbilical cord mesenchymal stem cells toward acellular foreskin treated with bacterial derivatives of monophosphoryl lipid A or supernatant of Lactobacillus acidophilus. Migration and homing are known as critical steps toward regeneration of damaged tissues via cell therapies. Among various cellular sources of stem cells, the umbilical cord has been thus recognized as an interesting one endowed with high benefits. Accordingly, the main objective of the present study was to determine whether monophosphoryl lipid A (MPLA) or supernatant of Lactobacillus acidophilus (SLA) could increase migration of human umbilical cord mesenchymal stem cells (hUMSCs) toward acellular foreskin or not. In this study, the hUMSCs were isolated and cultured through acellular MPLA- or SLA-treated foreskin. Expression of some migration genes (i.e., VCAM-1, MMP-2, VLA-4, CXCR-4, and VEGF) was also investigated using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). Moreover; vimentin, cytokeratin 5 (CK5), and matrix metalloproteinases-2 (MMP-2) were detected via immunohistochemistry (IHC) analysis. The hUMSCs in the presence of MPLA- or SLA-treated foreskin showed more tissue tropism compared with those in the control group. Besides, the scanning electron microscopy (SEM) results established that the hUMSCs had more migratory activity in the presence of MPLA- or SLA-treated foreskin than the untreated one. The IHC analysis results correspondingly indicated that expression of vimentin, CK5, and MMP-2 proteins had augmented in both treatments compared with those in the control group. It was concluded that MPLA had revealed more prominent results than SLA, even though both treatments could be regarded as inducing factors in migration. Ultimately, it was suggested to introduce the use of MPLA and probiotic components as a promising approach to improve therapies in regenerative medicine.William Treadwell House The William Treadwell House, also known as the Bruce Coleman House, is a private house located at 446 North Meridian Road in Hudson, Michigan. It was designated a Michigan State Historic Site and listed on the National Register of Historic Places in 1974. History William Treadwell grew up in Hudson, and began his career as a dry goods clerk. He later began working in the People's State Bank in Hudson to learn the business, and in 1859, William and his father Urias purchased the bank, with William providing the management and his father the capital. In 1862 William Treadwell married Mary Hester, and around the same time he began building this house. However, in early 1864, William Treadwell concocted a scheme to embezzle money from the bank, and on January 20, left town with $66,000 in his suitcase. Three weeks later he was caught in Ohio with his wife and in-laws and returned to Michigan, where he was tried and convicted. On the afternoon of his sentencing, Treadwell escaped jail with an accomplice. The accomplice later murdered Treadwell for the money in his pocket; Treadwell's body was found in the woods two weeks later. Treadwell never occupied the house he had built. The William Treadwell House is currently a private residence. Description The William Treadwell House is a two-story brick Italian Villa structure on a cut stone foundation. Two bays balance the main mass of the house, and it is surmounted by a gable roof. External architectural embellishments include elaborate brackets, wrought iron railings, rounded arch windows and doorways, and a two-tiered, square tower. Although the interior has been extensively altered, the exterior remains original. References Category:Houses on the National Register of Historic Places in Michigan Category:Houses in Hillsdale County, Michigan Category:Michigan State Historic Sites Category:National Register of Historic Places in Hillsdale County, Michigan起死回生 From what I've seen and read over the last 4-5 years he's consistently one of the top keepers in Serie B. As I said before, he's fine here for third choice. He doesn't really excel at anything but his fundamentals are good and I've seen the odd fantastic save.History With our name on every bottle, we are proud to bring you what is synonymous with the Castelli name: a passion for wines that are made with a relentless commitment to quality. The quaint country village of San Giorgio a Liri, in Italy’s Lazio region, was Sam and Maria Castelli’s birthplace. It’s a farming village that is home to many grain, corn and sunflower producers, but it was in the region’s vineyards that the Castelli family’s passion for wine developed. In 2004, the Castelli’s dream of a family-owned winery became a reality when, upon the slopes of Mt Shadforth, the Castelli Estate property was purchased – A 120 acre farm which overlooks Wilson’s Inlet, Mt. Lindesay and the lush countryside around Denmark. The property was acquired with a semi-complete winery which, with the family’s extensive construction and engineering experience, was later completed in 2006. With a strong commitment to quality, the next twelve months were spent putting together
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323, 378, 4873, 374, 15, 17, 13, 806, 273, 512, 13, 281, 29966, 253, 1755, 14, 3487, 3753, 273, 253, 378, 4873, 285, 1287, 247, 3282, 273, 1980, 12851, 28, 1273, 13, 281, 3819, 16933, 326, 35162, 1100, 253, 378, 4873, 434, 4156, 4549, 28, 285, 4720, 13, 281, 4684, 7888, 323, 625, 15850, 285, 3687, 32435, 13, 347, 253, 2278, 3389, 3916, 313, 9638, 481, 187, 187, 688, 247, 5825, 17901, 13, 752, 4135, 3133, 281, 452, 17288, 275, 7576, 3647, 275, 8170, 24520, 13411, 275, 1679, 685, 608, 1107, 556, 2668, 253, 444, 11236, 697, 12702, 15, 1244, 2568, 13, 849, 1027, 403, 616, 15824, 3946, 285, 13200, 6973, 31381, 32, 1281, 441, 9186, 253, 3946, 3284, 273, 253, 378, 4873, 15, 187, 187, 510, 3946, 3284, 27, 1199, 519, 80, 670, 2717, 32, 1712, 4538, 740, 94, 187, 4578, 18669, 187, 187, 510, 8215, 2746, 556, 644, 29210, 670, 697, 6024, 13200, 8130, 4715, 281, 2770, 13, 949, 35124, 13, 327, 25145, 272, 1980, 7888, 13, 533, 15586, 281, 12524, 250, 432, 8215, 22429, 13, 285, 8215, 1039, 273, 3811, 15, 24646, 13, 253, 5628, 1566, 3133, 625, 519, 35931, 285, 2283, 35232, 275, 697, 13870, 285, 24280, 13, 3738, 1335, 2444, 1755, 1066, 13, 285, 1919, 1024, 13, 7591, 281, 11377, 342, 5079, 5948, 281, 1287, 247, 625, 18380, 475, 2307, 316, 1444, 38911 ]	sense of exceptionalism. This may be due to its excessively slow operating machinery when it comes to tying its practice to vision. However, if this stems from not understanding complexity and the region, then the EU, as President Macron recently noted, is likely to find itself 'on the edge of a precipice', with no turning back.[14](#Fn14){ref-type="fn"} China's connectivity agenda and its global appeal? {#Sec7} ================================================== China, too, is grappling with the unravelling VUCA-world, but seemingly in a more adept way, even in the times of the global pandemic. In 2013, the Chinese Communist Party articulated its new external strategy of embracing complexity as 'One Belt One Road' or the BRI for external use, which embraces both the Silk Road Economic Belt and the 21st-century Maritime Silk Road (Yang [@CR76]). By 2015, the BRI policy framework consolidated into the 'Vision and Actions', with the State Council's authorisation, and the Leading Group was established to 'build a global community of shared future' ([@CR68], p. 9). We shall now examine the core tenets of this initiative, by looking at China's relations with Central Eurasia, using a 3P framework, to see, as in the EU case, how reflective and relational its engagement with the region is, and projected to be. The power element: cooperative but not relational? {#Sec8} ================================================== The BRI in a sense is China's response to the increasing uncertainty, fragmentation and diminishing control over both the internal and external environment. As Jinny Yan, China's Chief Economist for the BRI, insisted, it is designed to be a non-hierarchical and bottom-up engagement with all-level stakeholders, to develop their resilience and connectedness in the face of future challenges,[15](#Fn15){ref-type="fn"} which is very much in line with the EU's own way of thinking post-EUGS 2016. However, China seems to go about it in a much more concrete and determined way. According to the BRI founding document (Vision and Actions [@CR73], p. 3), it is supposed to:"promote the connectivity of Asian, European and African continents, and their adjacent seas, establish and strengthen partnerships among the countries along the BRI, set all-dimensional, multi-tiered and composite connectivity networks, and realise diversified, independent and sustainable development in these countries."It rests on five principles of peaceful co-existence, in line with the principles of the UN Charter (Ibid), and sets to pursue five specific cooperation priorities to 'boost \[multilateral\] cooperation platforms' for 'increasing mutual understanding, reaching consensus and deepening cooperation' (Ibid, p. 12). Cooperation priorities, as identified in 2015, focus on (1) better policy coordination; (2) development of infrastructural connectivity; (3) promotion of unimpeded trade; (4) enhancement of financial integration for better access to investment and resources; and (5) people-to-people bonds. In 2019 priorities were extended to include (6) industrial cooperation for China's investment in BRI countries. The key 'cooperation mechanisms' initially prioritised bilateral links (through joint committees) with the BRI governments (very similar to the EU governance of pre-2011) and mobilise existing multilateral mechanisms, such as Shanghai Cooperation Organisation, ASEAN Plus China (10+ 1), Asia--Pacific Economic Cooperation, and others (2015, p. 9). These mechanisms were supposed to 'support local authorities & general public of BRI countries to explore their historical and cultural heritage', thus specifically underscoring the salience of bottom-up governance and cooperative initiatives (Ibid p. 10). Having celebrated 5 years since inception, the BRI has enjoyed enormous progress in terms of its expansion and development of international cooperation, seeing some tangible results along the way. By the end of March 2019, Chinese government signed 173 cooperation agreements, with 125 countries and 29 international organisations, having expanded through Asia to Europe and Africa, and also procured new partnerships in Latin America and the South Pacific ([@CR68], p. 6). Every year the progress is monitored through consultation and evaluation discussions for further improvement. This way, once again, it resembles the EU effort to stay reflective over its action in realising its objectives. The scope of consultation, however, is different and fully in line with the Chinese ambition to achieve 'global consensus' (Ibid, p. 7). For example, with the intention to set up international fora, the first extensive consultation was held in May 2017 in Beijing involving over 16000 representatives from over 140 countries, and 80+ IOs, and producing 279 deliverables with 76 major items in five key areas, which as the official review states have now been implemented (Ibid). However, the key to this progress is not just about staying reflective and cooperative. Success undeniably rests on advancing the 'people-to-people' dimension, which admittedly has been the weakest point of the BRI to date and which has become the centrepiece of BRI 2.0, just like the concept of resilience in the EUGS ([@CR21]). In this regard, the key priority for BRI 2.0 lies with 'establishing a track two mechanism for dialogue' ([@CR68], p. 8)---to appeal to the 'hearts and minds' of the people involving civil society and various political organisations---parties, parliaments, think tanks, local authorities, business communities, the media and institutions for higher learning. With this new thinking, Chinese government is clearly on a steep learning curve to understand the workings of civil society which it has never done before, but as one interviewee commented, 'we are very quick and committed learners'.[16](#Fn16){ref-type="fn"} In addition to having bilateral engagement with BRI countries from Central Eurasia, China seems equally open to cooperating both with the EU and Russia as power contestants, vis-à-vis the region, often ceding the agenda-setting initiatives to partners. While the EU response has been cautious, Russia instead chooses to pursue the politics of 'sopryazhenia'---not aligning but moving in parallel[17](#Fn17){ref-type="fn"} (Ryzhkov [@CR83])---in an attempt to establish functioning relations with China (Bossuyt and Bolgova [@CR8]). The principles element: towards a shared or Chinese-led learning? {#Sec9} ================================================================= So, what has worked thus far in terms of developing traction and ensuring shared learning also to include a Chinese 'way of living', which as the official review document suggests, is premised on 'the principles of extensive consultation, joint contribution, and shared benefits' (2019, p. 7)? 'The people-to-people' dimension, while being under-invested, has nevertheless seen some interesting results. Initially, for example, the intention to win 'hearts and minds' of the populations, in Central Eurasia, was intended via school cooperation and student exchange (a strong EU measure). China put aside funds to invest up to 10,000 scholarships per year for BRI countries and provide financial support for Chinese cultural events. This commitment, as the 2019 review reports, has exceeded manifolds. Investment was granted to support diverse forms of cultural exchange, including Chinese and local festivals, bazaars and art fairs. In 2017 alone, about 40,000 scholarships were issued to students from the BRI countries, to study in China, which is about 66% of all students receiving such scholarships ([@CR68], p. 6). Memoranda of understanding were signed with 24 BRI countries on degree recognition; 152 Confucius institutes and about 149 Chinese language classrooms were set up in 54 BRI countries. Chinese Academy of Sciences for the first time opened its doors to 5000 students at the MA and Doctoral levels from BRI countries. China also issued \$2 billion in emergency food assistance; launched 100 Happy Homes projects for the poor and homeless, 100 anti-poverty and 100 health recovery projects across the BRI countries and Central Asia.[18](#Fn18){ref-type="fn"} This is not a small amount by any measure, even though it may seem negligible compared to the levels of investment to the other five BRI priorities (Yang [@CR76]). The people-to-people dimension is tangible for the communities and would normally work towards disseminating Chinese values and legitimising BRI expansion. This dimension is now seen by the Chinese government as a top priority for BRI 2.0, first of all, to mitigate the top-down nature of the BRI and develop a sense of local ownership; second, to fight corruption that undermines the BRI's global appeal; and finally, to connect communities for more cooperation and greater sustainability, as the review document claims (2019). In a nutshell, what China seems to have succeeded in accomplishing in Central Eurasia in less than 5 years has taken the ENP its lifetime. And yet, how different are their ordering practice and governing outcomes comparatively? Let us examine the practice element of the BRI. The practice element: much ado about nothing? {#Sec10} ============================================= The EU approach has been reflective about its external governing strategies learning to focus, through resilience, on empowering local communities, but struggling to decentre from EU norms, and EU way of living. Conversely, the Chinese model seems more adept and practicable in its pace and penetration, although still working top down, and until now, unable to engage with civil society to develop a more sustainable *modus operandi
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521, 1899, 285, 187, 45353, 434, 13 ]	, expediences: the true man is needed to discern even practical truth. Cromwell's advice about the Parliament's Army, early in the contest, How they were to dismiss their city-tapsters, flimsy riotous persons, and choose substantial yeomen, whose heart was in the work, to be soldiers for them: this is advice by a man who _saw_. Fact answers, if you see into Fact! Cromwell's _Ironsides_ were the embodiment of this insight of his; men fearing God; and without any other fear. No more conclusively genuine set of fighters ever trod the soil of England, or of any other land. Neither will we blame greatly that word of Cromwell's to them; which was so blamed: "If the King should meet me in battle, I would kill the King." Why not? These words were spoken to men who stood as before a Higher than Kings. They had set more than their own lives on the cast. The Parliament may call it, in official language, a fighting "_for_ the King;" but we, for our share, cannot understand that. To us it is no dilettante work, no sleek officiality; it is sheer rough death and earnest. They have brought it to the calling forth of _War_; horrid internecine fight, man grappling with man in fire-eyed rage--the _infernal_ element in man called forth, to try it by that! _Do_ that therefore; since that is the thing to be done.--The successes of Cromwell seem to me a very natural thing! Since he was not shot in battle, they were an inevitable thing. That such a man, with the eye to see, with the heart to dare, should advance, from post to post, from victory to victory, till the Huntingdon farmer became, by whatever name you might call him, the acknowledged Strongest Man in England, virtually the King of England, requires no magic to explain it!-- Precisely here, however, lies the rub for Cromwell. His other proceedings have all found advocates, and stand generally justified; but this dismissal of the Rump Parliament and assumption of the Protectorship, is what no one can pardon him. He had fairly grown to be King in England; Chief Man of the victorious party in England: but it seems he could not do without the King's Cloak, and sold himself to perdition in order to get it. Let us see a little how this was. England, Scotland, Ireland, all lying now subdued at the feet of the Puritan Parliament, the practical question arose, What was to be done with it? How will you govern these Nations, which Providence in a wondrous way has given-up to your disposal? Clearly those hundred surviving members of the Long Parliament, who sit there as supreme authority, cannot continue forever to sit. What is to be done?--It was a question which theoretical constitution-builders may find easy to answer; but to Cromwell, looking there into the real practical facts of it, there could be none more complicated. He asked of the Parliament, What it was they would decide upon? It was for the Parliament to say. Yet the Soldiers too, however contrary to Formula, they who had purchased this victory with their blood, it seemed to them that they also should have something to say in it! We will not "For all our fighting have nothing but a little piece of paper." We understand that the Law of God's Gospel, to which He through us has given the victory, shall establish itself, or try to establish itself, in this land! For three years, Cromwell says, this question had been sounded in the ears of the Parliament. They could make no answer; nothing but talk, talk. Perhaps it lies in the nature of parliamentary bodies; perhaps no Parliament could in such case make any answer but even that of talk, talk! Nevertheless the question must and shall be answered. You sixty men there, becoming fast odious, even despicable, to the whole nation, whom the nation already calls "Rump" Parliament, _you_ cannot continue to sit there; who or what, then, is to follow? "Free Parliament," right of election, constitutional formulas of one sort or the other--the thing is a hungry fact coming on us, which we must answer or be devoured by it! And who are you that prate of constitutional formulas, rights of Parliament? You have had to kill your king, to make pride's purges, to expel and banish by the law of the stronger whosoever would not let your cause prosper: there are but fifty or threescore of you left there, debating in these days. Tell us what we shall do; not in the way of formula, but of practicable fact! How they did finally answer, remains obscure to this day. The diligent Godwin himself admits that he cannot make it out. The likeliest is, that this poor Parliament still would not, and indeed could not, dissolve and disperse; that when it came to the point of actually dispersing, they again, for the tenth or twentieth time, adjourned it--and Cromwell's patience failed him. But we will take the favorablest hypothesis ever started for the Parliament; the favorablest, though I believe it is not the true one, but too favorable. According to this version: At the uttermost crisis, when Cromwell and his officers were met on the one hand, and the fifty or sixty Rump Members on the other, it was suddenly told Cromwell that the Rump in its despair _was_ answering in a very singular way; that in their splenetic, envious despair, to keep-out the Army at least, these men were hurrying through the House a kind of Reform Bill--Parliament to be chosen by the whole of England; equable electoral division into districts; free suffrage, and the rest of it! A very questionable, or indeed for _them_ an unquestionable, thing. Reform Bill, free suffrage of Englishmen? Why, the Royalists, themselves, silenced indeed but not exterminated, perhaps out_number_ us; the great numerical majority of England was always indifferent to our cause, merely looked at it and submitted to it. It is in weight and force, not by counting of heads, that we are the majority! And now with your Formulas and Reform Bills, the whole matter sorely won by our swords, shall again launch itself to sea; become a mere hope, and likelihood, _small_ even as a likelihood? And it is not a likelihood; it is a certainty, which we have won, by God's strength and our own right hands, and do now hold _here_. Cromwell walked down to these refractory Members; interrupted them in that rapid speed of their Reform Bill;--ordered them to begone, and talk there no more.--Can we not forgive him? Can we not understand him? John Milton, who looked on it all near at hand, could applaud him. The Reality had swept the Formulas away before it. I fancy, most men who were realities in England might see into the necessity of that. The strong daring man, therefore, has set all manner of Formulas and logical superficialities against him; has dared appeal to the genuine Fact of this England, Whether it will support him or not? It is curious to see how he struggles to govern in some constitutional way; find some Parliament to support him; but cannot. His first Parliament, the one they call "Barebones' Parliament," is, so to speak, a _Convocation of the Notables_. From all quarters of England the leading Ministers and chief Puritan Officials nominate the men most distinguished by religious reputation, influence, and attachment to the true cause: these are assembled to shape-out a plan. They sanctioned what was past; shaped as they could what was to come. They were scornfully called _Barebones' Parliament_, the man's name, it seems, was not _Barebones_, but Barbone--a good enough man. Nor was it a jest, their work; it was a most serious reality--a trial on the part of these Puritan Notables how far the Law of Christ could become the Law of this England. There were men of sense among them, men of some quality; men of deep piety I suppose the most of them were. They failed, it seems, and broke-down, endeavoring to reform the Court of Chancery! They dissolved themselves, as incompetent; delivered up their power again into the hands of the Lord-General Cromwell, to do with it what he liked and could. What _will_ he do with it? The Lord-General Cromwell, "Commander-in-chief of all the Forces raised and to be raised"; he hereby sees himself, at this unexampled juncture, as it were the one available Authority left in England, nothing between England and utter Anarchy but him alone. Such is the undeniable Fact of his position and England's,
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EscreverEsquerda(String, X + Largura - 100, temp - 0EscalaAltura -5, Fonte); sprintf(String,"Abaixar"); EscreverEsquerda(String, X + Largura - 100, temp - 1EscalaAltura -5, Fonte); if(DINO_BRAIN_QTD_OUTPUT == 3) { sprintf(String,"Avião"); EscreverEsquerda(String, X + Largura - 100, temp - 2EscalaAltura -5, Fonte); } /// Desenhar Conexoes for(int i=0; i<qtdNeuroEntrada-1; i++) { NeuroEntradaX[i] = XOrigem; NeuroEntradaY[i] = YOrigem - iEscalaAltura; } for(int i=0; i<qtdEscondidas; i++) { int qtdCamadaAnterior; Camada* CamadaAnterior; double XAnterior, YAnterior; if(i == 0) { qtdCamadaAnterior = qtdNeuroEntrada; CamadaAnterior = &MelhorDinossauro->Cerebro->CamadaEntrada; XAnterior = NeuroEntradaX; YAnterior = NeuroEntradaY; } else { qtdCamadaAnterior = qtdNeuroEscondidas; CamadaAnterior = &MelhorDinossauro->Cerebro->CamadaEscondida[i-1]; XAnterior = NeuroEscondidoX[i-1]; YAnterior = NeuroEscondidoY[i-1]; } for(int j=0; j<qtdNeuroEscondidas-1; j++) { NeuroEscondidoX[i][j] = XOrigem + (i+1)EscalaLargura; NeuroEscondidoY[i][j] = YOrigem - jEscalaAltura; for(int k=0; k<qtdCamadaAnterior-1; k++) { double Peso = MelhorDinossauro->Cerebro->CamadaEscondida[i].Neuronios[j].Peso[k]; double Saida = CamadaAnterior->Neuronios[k].Saida; if(PesoSaida > 0) { DesenharLinhaSimples(XAnterior[k], YAnterior[k], NeuroEscondidoX[i][j], NeuroEscondidoY[i][j], VERMELHO); } else { DesenharLinhaSimples(XAnterior[k], YAnterior[k], NeuroEscondidoX[i][j], NeuroEscondidoY[i][j], CINZA_CLARO); } } } } for(int i=0; i<qtdNeuroSaida; i++) { int UltimaCamada = MelhorDinossauro->Cerebro->QuantidadeEscondidas-1; double temp = YOrigem - (EscalaAltura(qtdNeuroEscondidas-2))/2.0 + (EscalaAltura(qtdNeuroSaida-1))/2.0; NeuroSaidaX[i] = XOrigem + (qtdEscondidas+1)EscalaLargura; NeuroSaidaY[i] = temp - iEscalaAltura; for(int k=0; k<qtdNeuroEscondidas-1; k++) { double Peso = MelhorDinossauro->Cerebro->CamadaSaida.Neuronios[i].Peso[k]; double Saida = MelhorDinossauro->Cerebro->CamadaEscondida[UltimaCamada].Neuronios[k].Saida; if(PesoSaida > 0) { DesenharLinhaSimples(NeuroEscondidoX[UltimaCamada][k], NeuroEscondidoY[UltimaCamada][k], NeuroSaidaX[i], NeuroSaidaY[i], VERMELHO); } else { DesenharLinhaSimples(NeuroEscondidoX[UltimaCamada][k], NeuroEscondidoY[UltimaCamada][k], NeuroSaidaX[i], NeuroSaidaY[i], CINZA_CLARO); } } } /// Desenhar Neuronios for(int i=0; i<qtdNeuroEntrada-1; i++) { PIG_Cor cor; double Opacidade; switch(i) { case 0: { Opacidade = fabs(Entrada[0])/800.0; cor = calcularCor(Opacidade, BRANCO); } break; case 1: { Opacidade = Entrada[1]/73.0; cor = calcularCor(Opacidade, BRANCO); } break; case 2: { Opacidade = Entrada[2]/90.0; cor = calcularCor(Opacidade, BRANCO); } break; case 3: { Opacidade = Entrada[3]/47.0; cor = calcularCor(Opacidade, BRANCO); } break; case 4: { Opacidade = Entrada[4]/8.0; if(Entrada[4] > 8) { Opacidade = 1; } cor = calcularCor(Opacidade, BRANCO); } break; case 5: { Opacidade = Entrada[5]/120.0; cor = calcularCor(Opacidade, BRANCO); } break; } DefinirColoracao(SpriteNeuronAtivado, cor); DefinirOpacidade(SpriteLuz, Opacidade255); DesenharSprite(SpriteLuz, NeuroEntradaX[i], NeuroEntradaY[i], 3.5TamanhoNeuronio, 3.5*TamanhoNeuronio, 0, 0); DesenharSprite(SpriteNeuronAtivado, NeuroEntradaX[i], NeuroEntradaY[i], TamanhoNeuronio, TamanhoNeuronio, 0, 0); DefinirOpacidade(SpriteLuz, 255); DefinirColoracao(SpriteNeuronAtivado, BRANCO); DesenharSprite(SpriteSeta, NeuroEntr
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520, 186, 3122, 4567, 14, 2713, 2245, 1738, 187, 4, 3182, 21628, 64, 9316, 64, 1372, 18, 64, 14364, 37009, 186, 186, 17, 89, 15651 ]	of luxury. But the garrison was too weak for the defence. A heavy cannonade commenced, and when the walls were shaken to their foundations, and eighty of the defenders had fallen, the signal was given and the place taken by assault. The garrison had acted bravely, but compassion was far from the hearts of the Republicans. The survivors were tried by court-martial, found guilty of fighting against the state, and hanged from those walls they had so bravely defended. Monk, on returning to Dublin, left a strong force in the Castle, for, though much shattered, it was still a position of considerable importance. But its days were numbered."Owen Roe O'Neill On his march towards Dublin (1647), finding Castleknock in the hands of the English, he determined to dislodge them. An effort was made to avert the blow. Colonel Trevor appeared at the head of a body of cavalry, but these were quickly routed, and O'Neill commenced another siege. This was too much for the veteran fortress, already tottering to its fall; it surrendered, and breathed its last in the hands of the Irish hero. Present dayThe green plot of ground enclosed within the old walls is used as a burial place for the priests of St. Vincent de Paul, and many zealous missioners, cut off in the bloom of life, are there interred. It was a happy thought. That spot, purpled with the blood of many a hero, and containing within its bosom the relics of the " departed brave", is now a consecrated cemetery. Here rest side by side the soldier and the priest of Erin. The one fought for Ireland's temporal interests, the other for her spiritual welfare..Books Dónal MacPolin and Peter Sobolewski, Blanchardstown, Castleknock and the Park, 2001, Cottage Publications James O'Driscoll, Cnucha: A history of Castleknock and district, 1977, privately issued Jim Lacey, A Candle in the Window, 1999 Marino Publications Tadhg O'Keeffe, Medieval Irish Buildings'', pp 230-231 2015 Four Courts Press References External links History of Castleknock Excerpt from book on Castleknock by Jim Lacey Fort of Cnucha and its Successors Category:Castles in Fingal Category:Castleknock Category:Ruins in the Republic of Ireland/* MIT License http://www.opensource.org/licenses/mit-license.php Author Tobias Koppers @sokra / "use strict"; //文件路径做为moduleID class moduleIDbyFilePath { constructor(options) { } apply(compiler) { compiler.plugin("compilation", (compilation) => { compilation.plugin("module-ids", (modules) => { modules.forEach((module) => { if(module.id === null) { module.id = module.dependencies[0].module.rawRequest } }); }); }); } } module.exports = moduleIDbyFilePath; Blog Your network is growing. You're adding fiber cable like there's no tomorrow ... all to keep up with the non-stop demand for bandwidth. With no end in sight, you have to protect your network and ensure the quality of its signal.Licorice Bridge Mix Bridge mix is the candy version of the everything pizza, the all-the-way cheeseburger, and the ice cream sundae with the works. It's all the good stuff in one spot. This section showcases licorice bridge mix by Jelly Belly, one of the most celebrated American candy manufacturers. Jelly Belly bridge mixes feature all the best bits and pieces of licorice candy mixed up together, perfect for the candy dish and perfect for parties. It's also perfect for black licorice lovers, when you need to give something a little out of the ordinary. Choose from several varieties and sizes below and make somebody, or several somebodies, very, very happy!/ * (C) Copyright 2005 Embedded Alley Solutions, Inc. * Dan Malek <[email protected]> * Copied from STx GP3. * Updates for Silicon Tx GP3 SSA board. * * (C) Copyright 2002,2003 Motorola,Inc. * Xianghua Xiao <[email protected]> * * SPDX-License-Identifier: GPL-2.0+ / / mpc8560ads board configuration file / / please refer to doc/README.mpc85xx for more info / / make sure you change the MAC address and other network params first, * search for CONFIG_ETHADDR,CONFIG_SERVERIP,etc in this file / #ifndef __CONFIG_H #define __CONFIG_H / High Level Configuration Options / #define CONFIG_BOOKE 1 / BOOKE / #define CONFIG_E500 1 / BOOKE e500 family / #define CONFIG_CPM2 1 / has CPM2 / #define CONFIG_STXSSA 1 / Silicon Tx GPPP SSA board specific/ #define CONFIG_MPC8560 1 #define CONFIG_SYS_TEXT_BASE 0xFFF80000 #define CONFIG_PCI / PCI ethernet support / #define CONFIG_PCI_INDIRECT_BRIDGE / indirect PCI bridge support / #define CONFIG_TSEC_ENET / tsec ethernet support/ #undef CONFIG_ETHER_ON_FCC / cpm FCC ethernet support / #define CONFIG_ENV_OVERWRITE #define CONFIG_FSL_LAW 1 / Use common FSL init code / / sysclk for MPC85xx / #define CONFIG_SYS_CLK_FREQ 33000000 / most pci cards are 33Mhz / / Blinkin' LEDs for Robert :-) / #define CONFIG_SHOW_ACTIVITY 1 / * These can be toggled for performance analysis, otherwise use default. / #define CONFIG_L2_CACHE / toggle L2 cache / #define CONFIG_BTB / toggle branch predition / #define CONFIG_BOARD_EARLY_INIT_F 1 / Call board_pre_init / #undef CONFIG_SYS_DRAM_TEST / memory test, takes time / #define CONFIG_SYS_MEMTEST_START 0x00200000 / memtest region / #define CONFIG_SYS_MEMTEST_END 0x00400000 / Localbus connector. There are many options that can be * connected here, including sdram or lots of flash. * This address, however, is used to configure a 256M local bus * window that includes the Config latch below. / #define CONFIG_SYS_LBC_OPTION_BASE 0xF0000000 / Localbus Extension / #define CONFIG_SYS_LBC_OPTION_SIZE 256 / 256MB / / There are various flash options used, we configure for the largest, * which is 64Mbytes. The CFI works fine and will discover the proper * sizes. / #ifdef CONFIG_STXSSA_4M #define CONFIG_SYS_FLASH_BASE 0xFFC00000 / start of 4 MiB flash / #else #define CONFIG_SYS_FLASH_BASE 0xFC000000 / start of 64 MiB flash / #endif #define CONFIG_SYS_BR0_PRELIM (CONFIG_SYS_FLASH_BASE \| 0x1801) / port size 32bit / #define CONFIG_SYS_OR0_PRELIM (CONFIG_SYS_FLASH_BASE \| 0x0FF7) #define CONFIG_SYS_FLASH_CFI 1 #define CONFIG_FLASH_CFI_DRIVER 1 #undef CONFIG_SYS_FLASH_USE_BUFFER_WRITE / use buffered writes (20x faster) / #define CONFIG_SYS_MAX_FLASH_SECT 256 / max number of sectors on one chip / #define CONFIG_SYS_MAX_FLASH_BANKS 1 / max number of memory banks / #define CONFIG_SYS_FLASH_BANKS_LIST { CONFIG_SYS_FLASH_BASE } #define CONFIG_SYS_FLASH_PROTECTION / The configuration latch is Chip Select 1. * It's an 8-bit latch in the lower 8 bits of the word. / #define CONFIG_SYS_LBC_CFGLATCH_BASE 0xFB000000 / Base of config latch / #define CONFIG_SYS_BR1_PRELIM 0xFB001801 / 32-bit port */ #define CONFIG_SYS_OR1_PRELIM 0xFFFF
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\leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx+\sum_{i\in\sigma}\int_{Q_{j}}\left(\exp\left(\left\|b_{i}(x)-\left(b_{i}\right)_{Q_{j}}\right\|^{s_{i}}\right)-1\right)dx\\ & \leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx+c\sum_{i\in\sigma}\|Q_{j}\|\\|b_{i}\\|_{expL^{s_{i}},Q_{j}}\\ & \leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx+c\sum_{i\in\sigma}\|Q_{j}\|\\|b_{i}\\|_{Osc_{expL^{s_{i}}}}\qquad\left[\\|b_{i}\\|_{Osc_{expL^{s_{i}}}}=1\right]\\ & \leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx+ck\|Q_{j}\|\\ & \leq c_k\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx. \end{split} \label{eq:1}$$ In the last step we used properties of the Calderón-Zygmund cubes. Plugging now that estimate, $$\begin{split} & c\sum_{i=1}^{k-1}\sum_{\sigma\in C_{i}^{k}}\sum_{j}\frac{1}{\varepsilon^{\#\sigma+1}}\inf_{z\in Q_{j}}M_{L(\log L)^{\sum_{i\in\sigma'}\frac{1}{s_{i}}+\varepsilon}}(w_{j})(z)\int_{Q_{j}}\Phi_{\sum_{i\in\sigma'}\frac{1}{s_{i}}}\left(\frac{\|f(x)\|}{\lambda}\left(b(x)-b_{Q_{j}}\right)_{\sigma}\right)dx\\ & \leq c_k\sum_{i=1}^{k-1}\sum_{\sigma\in C_{i}^{m}}\sum_{j}\frac{1}{\varepsilon^{\#\sigma+1}}\inf_{z\in Q_{j}}M_{L(\log L)^{\sum_{i\in\sigma'}\frac{1}{s_{i}}+\varepsilon}}(w_{j})(z)\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx\\ & \leq c_{k}\frac{1}{\varepsilon^{k}}\sum_{j}\inf_{z\in Q_{j}}M_{L(\log L)^{\frac{1}{s}+\varepsilon}}(w_{j})(z)\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx\\ & \leq c_{k}\frac{1}{\varepsilon^{k}}\sum_{j}\int_{Q_{j}}M_{L(\log L)^{\frac{1}{s}+\varepsilon}}(w_{j})(x)\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx\\ & \leq c_{k}\frac{1}{\varepsilon^{k}}\int_{\mathbb{R}^{n}}M_{L(\log L)^{\frac{1}{s}+\varepsilon}}(w_{j})(x)\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx \end{split}$$ For $L_{32}$ arguing in the same way we have that $$E_{2}\leq c_{k}\frac{1}{\varepsilon^{k}}\sum_{i=1}^{k-1}\sum_{\sigma\in C_{i}^{k}}\sum_{j}\inf_{z\in Q_{j}}M_{L(\log L)^{\frac{1}{s}+\varepsilon}}w_{j}(z)\int_{Q_{j}}\Phi_{\sum_{i\in\sigma'}\frac{1}{s_{i}}}\left(\frac{\|f_{Q_{j}}\|}{\lambda}\left(b(x)-b_{Q_{j}}\right)_{\sigma}\right)dx$$ The same computation used to obtain yields $$\int_{Q_{j}}\Phi_{\sum_{i\in\sigma'}\frac{1}{s_{i}}}\left(\frac{\|f_{Q_{j}}\|}{\lambda}\left(b(x)-b_{Q_{j}}\right)_{\sigma}\right)dx\leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f_{Q_{j}}\|}{\lambda}\right)dx+ck\|Q_{j}\|.$$ Now we see that using Jensen’s inequality, $$\begin{split} & \int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f_{Q_{j}}\|}{\lambda}\right)dx\leq\|Q_{j}\|\Phi_{\frac{1}{s}}\left(\frac{\|f\|_{Q_{j}}}{\lambda}\right)\\ \text{} & \leq\|Q_{j}\|\frac{1}{\|Q_{j}\|}\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx=\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx. \end{split}$$ Hence $$\int_{Q_{j}}\Phi_{\sum_{i\in\sigma'}\frac{1}{s_{i}}}\left(\frac{\|f_{Q_{j}}\|}{\lambda}\left(b(x)-b_{Q_{j}}\right)_{\sigma}\right)dx\leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{\|f(x)\|}{\lambda}\right)dx+ck\|Q_{j}\|$$ and we finish the estimate arguing as we did for $L_{31}$. [^1]: The first author was supported by Grant MTM2014-53850-P and the second author was supported by Grant MTM2012-30748, Spanish Government alright so this friday me and my boyfriend are having a sleep over party lolHe is always sleeping over at my place but this friday i want to make it cute and fun. So here are the ideas i have so far.Watching cute barbie movies (im obsessed he hates it but will anyways)I want to make dill popcorn and other kind of tea partish food any ideas?Play bored games,Build forts.Ill probably make him shave his beard and give him a cute facial thing and paint his nails black . hes one of them metal heads lol.um so anyways give me ideas ladies? im like the luckeist girl in the world to have a bf whos 27 mind u that will do this with me <3 aw we have the same kinda thingmy bf has long hair tons of tatoos periicngs in a death metal band all that stuff. In his stocking he is ge ttin guitar picks. razors . socks. shampoo a brush cuz he donest have one for his long hair a spiked belt. chocolate and i think im gunna make him some felt monsters and spiders go to like spencers and get your bf some cute cheap belt buckles and shot glassesLinters For a long time, I’ve thought that code linting tools (linters) were a good idea in principle, but too annoying to use on a regular basis. Besides, I’ve always been pretty particular about my coding style, so I felt like I didn’t need a tool to help me do something I already do anyway. I have used SmallLint (a.k.a., the Code Critic) to good effect in my Visualworks Smalltalk projects, even going so far as to write some additional rules and integrating the tool into my automated builds. But even there, some of the rules would produce false positives that I didn’t think needed to change. As our team started working with ES6, React, and Redux, we decided to adopt linters to help us out. I was a bit reluctant, but we all felt like it would be good to have some “training wheels” as we were learning the new tools. I privately felt like we’d probably out-grow the need for linting after a month or two. I have to come right out and say it: I was totally wrong. We adopted ESLint for JavaScript and sass-lint for CSS. We set up initial configurations for both tools that matched the way we wanted to write our code, and we’
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425, 618, 321, 1942, 1296, 343, 4057, 826, 13812, 711, 3510, 277, 8, 1215, 1814, 868, 15, 22955, 298, 8, 66, 1137, 321, 247, 14, 85, 14, 300, 8429, 8097, 343, 4057, 18208, 4743, 3736, 657, 21269, 358, 1559, 494, 420, 48304, 572, 8, 300, 863, 725, 489, 10992, 278, 1502, 1162, 49130, 372, 278, 1502, 2176, 265, 50052, 290, 569, 7113, 20792, 14330, 4057, 8225, 250, 372, 7113, 25604, 15, 3035, 2636, 6483, 13, 4057, 826, 18880, 711, 278, 1502, 7539, 30497, 463, 1162, 826, 298 ]	des extensions de concept est un critère nécessaire et suffisant pour qu'existe entre concepts la relation qui correspond à l'identité pour les objets. J'ajoute que j'emploie le terme « identique », sans autre précision, au sens de « pas différent de », « coïncidant avec », « le même que ». Les logiciens psychologiques ne peuvent pas mieux comprendre l'identité que la définition. Cette relation d'identité ne peut que leur poser une énigme ; si les mots désignaient constamment des représentations, on ne pourrait jamais dire « _A_ est la même chose que _B_ » car il faudrait déjà distinguer _A_ de _B_ , et on aurait des représentations différentes. Cependant, je partage avec l'auteur l'idée que l'explication proposée par Leibniz : _eadem sont quorum unum potest substitui alteri salva veritate_ ne mérite pas d'être appelée définition, mais pour d'autres raisons que lui. On pourrait dire que la proposition de Leibniz est un principe qui exprime l'essence de la relation d'identité ; en tant que tel, son importance est capitale. Quant à l'explication proposée par l'auteur (p. 108), « on dira simplement que deux contenus quelconques sont identiques s'il y a identité des caractères qui constituent le foyer de l'intérêt », je la trouve insipide. Venons-en aux détails. Selon l'auteur, la donnée d'un nombre se rapporte à la totalité (ensemble, multiplicité) des objets comptés (p. 185). Une totalité de ce genre est parfaitement exprimée au moyen de la conjonction « et ». On devrait s'attendre à ce que l'attribution d'un nombre soit toujours de la forme : « _A_ et _B_ et _C_ et... _Q_ sont _n_ », ou puisse être ramenée à cette forme. Mais que peut bien apporter la proposition « Berlin et Dresde et Munich sont trois » ou, ce qui doit revenir au même, « Berlin et Dresde et Munich sont quelque chose et quelque chose et quelque chose » ? Qui se donnerait la peine de poser une question pour obtenir une telle réponse ? En aucun cas, on ne saurait y voir l'affirmation que Berlin est différent de Dresde, Dresde différent de Munich, et Munich de Berlin ; et en fait l'énoncé, au moins sous sa deuxième forme, ne dit pas que Berlin et Dresde sont différents, ni qu'ils sont identiques. Il est remarquable que la langue quotidienne ne donne aucun exemple d'un énoncé de cette forme quand elle attribue un nombre. Et si jamais on rencontre cette forme, elle n'a pas le sens d'une attribution de nombre. Je n'ai trouvé que deux emplois de cette forme : en premier lieu, avec le terme « deux » pour exprimer la diversité : « Des bettes et des raves cela fait deux » ; en second lieu, avec le terme numérique « un » pour exprimer l'identité — « Moi et mon Père sommes un ». Cet exemple est particulièrement gênant car, d'après notre auteur, on devrait avoir « sont quelque chose et quelque chose » ou « sont deux ». En réalité on ne demande pas « combien font César et Pompée et Londres et Edimbourg ? » ni « combien font la Grande-Bretagne et l'Irlande ? » — et je serais curieux de la réponse de l'auteur. Mais on demande, par exemple, « Combien Mars a-t-il de satellites ? » ou « Quel est le nombre des satellites de Mars ? » et la réponse : « Le nombre des satellites de Mars est deux » donne une information qui méritait la question. On remarquera que la question et la réponse comportent un terme conceptuel ou une désignation conceptuelle complexe, au lieu du « et » requis selon notre auteur. Comment se tire-t-il de la difficulté ? En disant que le nombre appartient à l'extension de concept, c'est-à-dire à la totalité. « Mais on dira de manière seulement indirecte que le concept a cette propriété, à savoir que le nombre appartient à son extension » (p. 189). C'est accorder tout ce que j'affirme : l'attribution d'un nombre énonce quelque chose d'un concept. Et je ne disputerai pas si l'énoncé porte directement sur le concept et indirectement sur l'extension, ou directement sur l'extension et indirectement sur le concept ; car l'un va avec l'autre. Il est certain en tout cas que, dans une proposition attribuant un nombre, ne sont désignés directement ni une totalité ni une extension de concept mais un concept. Si l'auteur employait le terme « extension de concept » au sens où je l'entends, nous différerions bien peu sur le sens d'une proposition énonçant un nombre. Tel n'est pas le cas, et l'extension de concept n'est pas une totalité au sens de l'auteur. Un concept sous lequel tombe un seul objet a une extension aussi déterminée qu'un concept sous lequel ne tombe aucun objet ou sous lequel tombent une infinité d'objets. Or, dans ces derniers cas, il n'y a pas, selon M. Husserl, de totalité. Le sens des mots « extension du concept satellite de Mars » est autre que celui des mots « Deimos et Phoebus », et la proposition « le nombre de Deimos et Phoebus est deux », si jamais elle contient une pensée, contient une pensée à coup sûr différente de la pensée exprimée dans « le nombre des satellites de Mars est deux ». Du fait que personne n'emploie une proposition de la première forme pour attribuer un nombre, le sens d'une proposition qui attribue un nombre a échappé à notre auteur. Examinons de plus près la manière dont prend naissance une totalité (p. 77 et s.). J'avoue que je ne suis pas parvenu à construire une totalité en suivant les directives de l'auteur. Dans la liaison collective, les contenus doivent seulement être pensés ou représentés ensemble, sans que soit pensée ou représentée aucune liaison ou relation entre ces contenus (p. 79). Je n'y arrive pas. Je ne peux pas me représenter le rouge, la lune, et Napoléon sans les imaginer dans un certain lieu, par exemple le rouge d'un village en flammes devant lequel se dresse la silhouette de Napoléon dans la lumière du clair de lune. Je me représente comme un tout ce qui m'est simultanément présent, et je ne peux pas faire abstraction du lien sans perdre le tout. Je soupçonne qu'il n'y a pas dans mon âme ce que l'auteur appelle « totalité », « ensemble », « multiplicité », une représentation des parties dont l'unité n'est pas représentée en même temps que les parties, bien qu'elle soit donnée en même temps. Aussi n'y a-t-il pas lieu de s'étonner que l'auteur dise un peu plus loin (p. 242), à propos de l'ensemble, qu'il possède un moment figurai qui le caractérise comme un tout, une articulation. Il parle (p. 235) d'une suite, d'un essaim, d'une chaîne, d'un tas, comme de types particuliers d'ensembles. Il n'y aurait donc aucune unité sensible dans la représentation d'un essaim ? Ou bien cette unité est-elle donnée à côté du lien collectif ? En ce cas, elle n'appartient pas à la totalité, et le moment figurai ne saurait servir à la distinction des types d'ensembles. Comment l'auteur a-t-il pu venir à cette opinion ? Vraisemblablement parce qu'il attribue aux mots et suites de mots certaines représentations déterminées à titre de dénotation. En ce cas, à la suite des mots « rouge et la l
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2652, 471, 12505, 316, 15, 380, 19479, 316, 3, 387, 253, 990, 273, 616, 1416, 310, 271, 10390, 692, 1850, 5341, 29791, 390 ]	was adopted from the Covenant.[1] The Jiralhanae within the Covenant were zealous beings, known for their willingness to cling to ancient, bloody traditions and many among the Jiralhanae, notably Tartarus, held an unwavering belief in the words of the Prophets and in the promise of the Great Journey, however not all Jiralhanae were fanatical adherents to the Covenant religion and many Jiralhanae had soon abandoned the Covenant religion upon the collapse of the Covenant.[2] Their homeworld of Doisac is war-torn, and Jiralhanae are known for their particular joy in vicious activities, complimented by regimented discipline. As part of the Covenant, Jiralhanae were required as a prerequisite to convert to the Prophets' religion of worshipping the Forerunners. Previously, their culture revolved around the worship of totems and idols[1] and their religion was based on the lunar cycles of Doisac's three moons,[2] but they made swift converts due to their search for theological meaning.[14] The Jiralhanae within the Covenant were one of the most fanatical adherents to the Prophets' faith, although they seemed to hold little concept of sanctity, evidenced by Tartarus' improper handling of the "Oracle" 343 Guilty Spark.[17][38] Following the dissolution of the Covenant most Jiralhanae abandoned their belief in the Great Journey.[2] The Jiralhanae fighting style is forceful, utilitarian, and pragmatic.[6] They prefer using weapons from their homeworld rather than the Covenant's standard plasma-based firearms. Jiralhanae weapons are notable for being extremely dangerous, somewhat primitive and brutal, and always featuring a blade attachment such as the Type-25 Spiker, Type-52 Mauler, Type-25 Brute Shot, and the Type-2 gravity hammer. These weapons show their barbaric nature, for example, the fact that all of the weapons are named after ways of injury or causing bodily harm to another being. The many spikes and serrated edges that adorn their race's weapons, vehicles and armor further support this. However, they do have their own type of plasma rifle. The Sangheili abhorred the Jiralhanae weapons due to their primitive nature, but allowed them to be serviced in low numbers.[39] Unlike the Sangheili, the Jiralhanae have no qualms about using human weaponry. Some were seen using human shotguns during the Human-Covenant War.[40] The Jiralhanae are disdainful of every other species except the San'Shyuum.[14] In general, Jiralhanae have a pronounced dislike of the Sangheili because the former believe they are better protectors of the Prophets than the Sangheili, as well as the Sangheili's mistreatment of the species during the Covenant's reign.[41] The High Prophet of Truth took advantage of this to ignite the Great Schism during the Battle of Installation 05.[40] However, some Jiralhanae have surrendered and are willing to labor under the Sangheili after the end of the war.[42] Jiralhanae interpret direct eye contact as a challenge. They have been known to brutally beat to death humans who have boldly dared to stare at them.[43] Jiralhanae society is dominated by a fierce pack culture and a focus on lineage. Familial bonds tie each member to the other, forcing them into states of berserker rage and desperate mourning for their fallen pack mates should one die in battle. Jiralhanae society is an authoritarian dictatorship controlled by the strongest male;[2] dominance is established by the social, martial, and sexual success of the patriarch. Patricide is an common side effect of the patriarchy due to the ambition seeded within many Jiralhanae to rise to the top of a hierarchy.[44] Female Jiralhanae generally serve as mothers and caretakers.[2] No females have been observed in military roles.[45] A Jiralhanae's blood relation to another Jiralhanae did not offer subordinates immunity from discipline.[46] Each pack is led by a prominent chieftain who wields a ceremonial gravity hammer, passed from one leader to another upon his death, to denote his status. A Jiralhanae becomes a pack chieftain by challenging the current chieftain to a mortal duel; the victor claims the title after executing the other. The chieftain rules his pack like his own empire. An individual's rank is measured by success on and off the battlefield, unlike the more martial Sangheili.[1] Interactions among the Jiralhanae are dominated by personal status, which they display through decoration and ornate armor.[45] Jiralhanae exhibit a variety of grooming styles to denote their status and pack affiliation. Jiralhanae typically are either clean shaven or sport mohawks, goatees or beards. However, some Jiralhanae packs do away with shaving altogether. Some Jiralhanae packs also adorn themselves with tattoos over their entire bodies.[47] Due to their combative and aggressive nature, the Jiralhanae lack a single cohesive government. Instead, Jiralhanae society can be viewed as an extension of their pack structure, but with a number of different levels: Skeins are the largest social division of Jiralhanae, "meta-clans" formed out of multiple packs sharing a similar philosophy and interests. A given skein is dominated by the most powerful clan within. During the First Immolation, most Jiralhanae fell into one of two dominant skeins: the Rh'tol and the Vheiloth. The two skeins display stark cultural and political differences: the Rh'tol are considered more primitive and aggressive, while the Vheiloth are generally more sophisticated and open to new ideas.[2] Alpha Tribes[48] and master-packs are seemingly dominant clans or groupings consisting of multiple packs. Prior to contact with the Covenant, rival master-packs reduced Jiralhanae society to a pre-industrial level through warfare.[12] Packs range in size and importance, with less important packs made up largely of Unggoy or Kig-Yar forces and led by a low-ranked Jiralhanae, and more important packs led by War Chieftains and comprised of more experienced veteran Jiralhanae bodyguards.[49] Whereas the Sangheili used to command the Covenant's military and serve as the personal protectors of the San'Shyuum, the Jiralhanae primarily served as the Covenant's shock troops and secret police. This changed with the outbreak of the Great Schism, when the Jiralhanae supplanted the Sangheili in all areas of the Covenant military.[9][36] The Jiralhanae treated all the species under their command as expendable cannon fodder. If a subordinate failed to complete their task in any aspect, the leading Jiralhanae would enact a swift punishment, generally execution.[45] Eager to prove themselves superior over the Sangheili, the Jiralhanae often acted with no respect for the lives of civilians or other races.[6] Sangheili and Jiralhanae fleets were largely segregated, but this was not always the case.[51] Believing that the Jiralhanae posed a threat to both the Sangheili and the Covenant, a union of Sangheili commanders convinced the Covenant High Council to impose restrictions on the technology used by the Jiralhanae. The number of Jiralhanae shipmasters was limited and the weaponry on Jiralhanae ships was mostly disabled.[6][16] Jiralhanae units are typically deployed in packs led by one or more chieftains or captains. Apart from their role as shock troopers, they often fill a similar combat role to the Sangheili, as both typically command groups of lesser infantry. However, Jiralhanae generally were not equipped with energy shields (except for captains and chieftains) until the outbreak of the Great Schism, when power armor saw widespread use among Jiralhanae forces. According to Arbiter Thel 'Vadam, Unggoy serving under the Jiralhanae during the Great Schism exhibited newfound courage due to fear of their masters.[52] The native Jiralhanae language is animalistic, incorporating a wide range of sounds from growls and barks to howls and roars,[53] though Jiralhanae also express emotions through scents and musks. Young Jiralhanae have difficulty controlling the release of these scents, but learn how to moderate them as they grow older.[37] A communal howl is often made by the packchieftain as a sign of celebration, and failure to participate in the howl is a serious sign of disrespect to the Chieftain's authority.[54] Most known Jiralhanae have Latin-sounding names, such as Tartarus and Bracktanus. The "-us" at the end of their name is an honorific denoting maturity or
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Amherst has one that’s bigger than this and I think Temple University has one that’s bigger than these. We had these all cabled up so you could mow underneath this and all, and that same storm that did all the damage just didn’t break the cables but it took the screw eyes and straightened them right out flat and all these limbs came down on the ground. We lifted them up this high just to get some blocks underneath. The biggest problem we’ve had with it is right in the dead center. We’re always losing something out of the center, even the one that’s across the way over there we lost. Any of these clump things, you’re going to lose something in the middle, whether they get crowded out or what, I don’t know. The same thing happened to us on that one over there. PP: We’re sitting on the bench under the Japanese maple. Is this an original bench location? DS: No, this bench is one – there was a bench here, yes. This is not one of the originals. PP: Was the bench like this? DS: Yes. PP: A different design? DS: No, it was like this. PP: So, they did buy some benches that weren’t custom made? DS: Oh yes. Some of them are knockouts, a lot of those around the swimming pool. I bought two batches from Country Casual since then. I bought five here a couple years ago because they were all rotting out. But you notice, most of our benches, we have them up on a brick or on a flagstone, something to get the legs off the ground. That seems to be where they rot. PP: We see a bench over by the Gothic Garden, is that an original bench location? DS: Yes, but there was a Gothic Garden there, that was a complete circle at one time over there. PP: The circle in front of that bench? DS: Yes, you had to walk in right on this upper end here, there’s an opening, that circle came around this way and all that box was terrible. It looked like it had been buried. I’d tell you it was buried, but I don’t want it on that, shut that off. PP: The Gothic Garden was a circular boxwood area about fifteen feet across and there’s a little bench inside and there was only one way in. DS: Yes. PP: And someone piled dirt up around them and caused them to die on one side. DS: That’s what killed them as far as I’m concerned. Also this was landscaped at the time when little secret gardens were the thing for most of the people. This is kind of a little – you had to go in through the hedge to get in there. PP: Interesting idea. We see a stone tub up there towards the Rose Garden. Tell me the history of that, where it was, what it is. DS: I don’t know what, we just always called it the bathtub but originally I think it was on the Bowling Green, on the west end of the Bowling Green. I’ve seen pictures of it there, but it sat right here ever since I’ve been here, sat right over on that spot. PP: Has it ever held water? DS: Not that I know of. PP: Is it made to hold water? DS: There’s a drain in it. A lot of people have had their pictures taken sitting in there like they were taking a bath. PP: Have you ever rebuilt this walk here, this brick walk? DS: About once a week we’re replacing brick in here and you’ll be doing it for the next fifty years, as long as you’ve got tree roots. You can come in here today and replace every single one of these bricks and come back next week and replace some more of them, especially right in this area right through here. PP: Makes it kind of tough for the wheelchairs, doesn’t it? DS: It does, but what’s the worse thing on the brick walks here, they’re not in a concrete base or anything but they’re just laying on the ground, they’re in sand, and in the wintertime they freeze and thaw. [end of tape 4] DS: This is Crab Hill and the only thing that has changed – we only have one more of the big old crabs still here. We had four and two of them have died, and we lost another one right in this spot from a hurricane. They went down and cleaned out a bunch of little ones we had. This one here that we’re talking about now taking down, it’s about ready to go and that one down there are the two oldest. And there’s a couple over back on, not this group in here, but that over in there, they were in here then. The yucca was here, the daylily beds and the iris beds were here, except for those few that are over near the swimming pool, and that’s some of the new hybrids we put in to give more color through the summertime. The [inaudible] are way down at the bottom here on the left hand side, that was something that was put in here many years ago. Mr. Kearney put that in, in fact, in the files there’s a picture of Matt and two or three of the crew bringing that down the hill on a platform and putting it in. The fringe tree, I bought about five of those and we stuck them in various parts of the garden and that one has been knocked down to the ground twice with the cold weather, for some reason, but now it’s come flourishing right back. And also right beside it there’s a little flowering almond, that was in here when I came here and that thing never gets over three foot high and that’s the only one we’ve got on the place and it blooms its head off. It’s straight down beyond the yucca. It’s just a little tiny thing, that blooms its head off. This is a Chinese or Japanese lilac and it blooms real late in the last of the spring shrubs bloom. It doesn’t have a very good fragrance but it’s something that’s been here for years and years and years. The magnolia behind it was in there, the [inaudible], the Canadian cherry behind that, that was in here when I came and all of that planting that’s over in the valley. The forsythia over in there, those were all in here. That tulip poplar in here, which is fifteen–eighteen inches across now, that was a small tree that was put in here just before I came. And the big cherry that’s in there, that was already there. There haven’t been that many changes. We have added some crabs when the old ones went by, but we still kept the crabapples. PP: Have the beds ever been dug or divided? DS: Now we’ve cleaned them out and made them smaller, some of the bigger clumps. In fact, we tightened them and split them up and moved them around, there was just too much of it here anymore. Those iris beds, they were already here. PP: What about the yucca? DS: The yucca was in there. The day I came here that thing was in here then and it’s been here for years. And the daylilies around us, that bed has not changed in here at all. PP: What about the bed of the winter flowering jasmine in the ivy down by – DS: That winter flowering jasmine, that was put in there. When they redid the North Vista walls and redid that end down there where the railing is, after they got that – in fact when I came here they were just finishing the stone carving, they hadn’t even put the walls up – and the jasmine had just gone in there like a year or two before that. And from what Mr. Kearney told me, he said that was put in temporarily and they never changed it so it’s worked out fairly well. It’s a nice show in the middle of the winter, real nice, and we’ve let the ivy come underneath it to give it a green background. But when it is in bloom the jasmine will lose its leaf and it blooms its best on the bare step and with that green background it’s much better. PP: Are these any particular variety of crabapple that you use? DS: I don’t even know the name of this old one. PP: Do you know the names of the younger ones? DS: There’s some red jades in there and the zumi down on that bottom side and I think there’s some coronaria in here and there’s a couple of sargents in here. PP: Are these daylilies, these are the orange lilies and the lemon lilies, or? DS: Yes, all of these are the old orange ones, but that group up in there, there’s a double yellow, there’s some single yellow hybrids up there, and this is that red that has the yellow streak in it, just for variety. I got
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4984, 15, 5595, 15538, 13, 352, 3400, 271, 6714, 6460, 5684, 275, 667, 1511, 273, 5079, 38111, 28, 12401, 378, 1432, 518, 1432, 757, 13, 352, 1057, 417, 12129, 875, 346, 46052, 3, 5079, 24184, 30153, 285, 346, 26944, 3, 5079 ]	, neither official was aware of the complete circumstances surrounding the defendant wood, namely the quantity of wood involved. Regardless, the Court declines to find that a lack of unanimity on the application of the statutory provisions based on incomplete facts is in any manner dispositive of this issue. The Court is inclined however to agree with the Government's position that "it cannot be seriously argued that the common understanding of what would be involved in the movement's of ones' belongings from one household to another would normally include enough building material to replace the floors and doors in an entire house with over 2,000 square feet of living space." (Govt. Opp. Cl. Mot. Summ. J. 35.) It is virtually impossible to believe that a person of ordinary intelligence and understanding would believe that this is typically or appropriately designated as a normal part of a household move. Claimants' weak arguments taken in conjunction with the level of deference and flexibility accorded statutes imposing civil penalties lead the Court to conclude that the statutes indicated by Claimants are not void for vagueness. Therefore, the Court denies Claimants Motion for Summary Judgment based on due process claims grounded in allegations of unconstitutional vagueness because Claimants have made an inadequate showing that someone of ordinary intelligence would be unable to ascertain from the relevant statutory provisions that this quantity of building materials would not qualify as household effects so as to be exempt from CITES's Certificate of Origin requirements. 5. Valuation The Court denies Claimants' Motion for Summary Judgment based on improper valuation because regardless of the value of the property and whether the Government initiated the forfeiture action as an administrative or a judicial forfeiture action, Claimants' decision to contest the forfeiture required the matter to proceed judicially, and therefore the procedural posture of this case and the ultimate outcome would have been the same. Following seizure, the retail value of the property must be ascertained. 7 C.F.R. § 356.2. If the property is valued at less than $10,000 the property must be forfeited administratively, and if it is valued at more than $10,000 it must be referred to the United States Attorney's Office for the institution of forfeiture proceedings in the appropriate United States District Court. 7 C.F.R. § 356.3; 7 C.F.R. § 356.4. If after proper notification of the commencement of an administrative forfeiture, a claim is filed, the action must be converted to a contested judicial forfeiture. 19 U.S.C. § 1608. Claimant devotes significant energy to contesting the manner in which the appraisal of the defendant wood was conducted and finding fault in the disparity in value produced by multiple appraisals. After all of this, Claimants conclude that the "correct" valuation was $6,400, and that therefore this action should have been commenced administratively and because it was not, they are entitled to summary judgment. The Court declines to entertain this dispute over the value of the wood because, if nothing else is clearly ascertainable from the voluminous record in this matter, it is certain that regardless of whether this forfeiture was commenced administratively or judicially, the Thompsons would have filed a claim contesting the forfeiture of their property. The matter would have been automatically transferred to this Court's jurisdiction and would have subsequently proceeded in the exact same manner that it has. 19 U.S.C. § 1608. The Court therefore denies Claimants' Motion for Summary Judgment based on improper valuation of the defendant wood because even if the valuation had been determined as they preferred, their decision to contest the forfeiture would have resulted in the same procedural posture in this matter. 6. Eighth Amendment: Excessive Penalty The Court denies Claimants' Motion for Summary Judgment based on allegations that the forfeiture of the defendant wood constitutes an excessive penalty because Claimants have failed to satisfy their burden of demonstrating that the forfeiture was grossly disproportionate by a preponderance of the evidence. 18 U.S.C. § 983(g) codifies the constitutional proscription against excessive fines and permits claimants in civil forfeiture actions to challenge such forfeitures as constitutionally excessive. In recent years, prior to the promulgation of § 983, the Supreme Court considered the application of the Excessive Fines Clause of the Eighth Amendment to forfeiture actions on two occasionsfirst in 1983 in Austin v. United States and again in United States v. Bajakajian, in 1998. Austin v. United States, 509 U.S. 602, 113 S.Ct. 2801, 125 L.Ed.2d 488 (1993); United States v. Bajakajian, 524 U.S. 321, 118 S.Ct. 2028, 141 L.Ed.2d 314 (1998). Following the issuance of those two opinions, the Fourth Circuit considered the implications of these two cases when read in conjunction with one another in United States v. Ahmad, 213 F.3d 805 (4th Cir.2000). In Austin, the Court "held that the limitations imposed by the Excessive Fines Clause of the Eighth Amendment apply to in rem civil forfeiture proceedings if the forfeiture, at least `in part' constitutes punishment." See Ahmad, 213 F.3d at 812 (summarizing Austin). In distinguishing between punitive and remedial forfeitures, the Austin Court concluded that "forfeiture generally and statutory in rem forfeiture in particular historically have been understood, at least in part, as punishment." Austin, 509 U.S. at 618, 113 S.Ct. 2801. The Court went on to indicate that forfeitures involving the seizures of instrumentalities were more appropriately designated as remedial. Id. at 619, 113 S.Ct. 2801. The Court's analysis stopped short, however, of setting out a test for determining whether a forfeiture is in fact constitutionally excessive. Id. at 622, 113 S.Ct. 2801. Five years later, this issue returned before the Court in Bajakajian, and this time it chose to articulate a test for determining whether a punitive forfeiture violated the Excessive Fines Clause. The Court in Bajakajian, first created an unclear distinction between traditional and modern civil in rem forfeitures, indicating that "[t]raditional in rem forfeitures were... not considered punishment against the individual for an offense" and that "[b]ecause they were viewed as nonpunitive, such forfeitures traditionally were considered to occupy a place outside the domain of the Excessive Fines Clause." Bajakajian, 524 U.S. at 331, 118 S.Ct. 2028. These forfeitures were to be distinguished from more modern forfeiture statutes that have "blurred the traditional distinction between civil in rem and criminal in personam forfeiture." Id. at n. 6.[8] However, the Court gave very little guidance on categorizing forfeitures as traditional versus modern. In Bajakajian the property that was the subject of the forfeiture was money that Bajakajian failed to report upon exportation. The Government urged the Court to designate the cash a instrumentality on the basis that it not only facilitated the violation of the law, but was "the very sine qua non of the crime." Id. at 333, 118 S.Ct. 2028. The Court declined to extend the definition of instrumentality as such, noting that "the currency in question is not an instrumentality in any event.... [It] is merely the subject of the crime of failure to report." Id. at 334 n. 9, 118 S.Ct. 2028. The Fourth Circuit in Ahmad would later read Bajakajian as setting forth the following factors for the next step in the Court's analysisassessing the gravity of the offense: "the nature and extent of the criminal activity, other related illegal activities ..., the extent of the harm caused by the offense, and the maximum penalties a court could have imposed for the offense." Ahmad, 213 F.3d at 816. Ahmad was decided on May 25, 2000. CAFRA became law on August 23, 2000, and included the provisions of 18 U.S.C. § 983(g): (g) Proportionality (1) The claimant under subsection (a)(4) may petition the court to determine whether the forfeiture was constitutionally excessive (2) In making the determination, the court shall compare the forfeiture to the gravity of the offense giving rise to the forfeiture. (3) The claimant shall have the burden of establishing that the forfeiture is grossly disproportional by a preponderance of the evidence at a hearing conducted by the court without a jury. (4) If the court finds that the forfeiture is grossly disproportional to the offense it shall reduce or eliminate the forfeiture as necessary to avoid a violation of the Excessive Fines Clause of the Eighth Amendment. 18 U.S.C. § 983(g). Few federal circuit courts have had the occasion to evaluate Excessive Fines Clause challenges to civil forfeitures under § 983(g).[9] For this reason it is reasonable to look at what has been written regarding reconciling the aforementioned Supreme Court precedent with recent statutory modifications. Congress essentially codified the Bajakajian decision in 18 U.S.C. § 983(g), enacted as part of the CAFRA. Although Bajakajian is a criminal forfeiture case, the codification applies only to civil forfeiture cases. It modifies or goes beyond what the Supreme Court held in several respects. First, it places the burden of establishing gross disproportionality on the claimant, by a preponderance of the evidence. Second, it makes clear that the excessiveness issue is to be decided by the court without a jury. Most importantly, it provides an excessiveness defense in any type of civil forfeiture; unlike Bajakajian, it does not distinguish between "traditional" civil forfeitures and "modern" civil
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Improving outcome in high-grade gliomas requires an emphasis on discovering novel therapies and improving the design of adjuvant trials.For Against Liberty City still little more than a backdrop, story a little too led by the hand There’s absolutely little doubt whatsoever that Grand Theft Auto IV is one of the very best gaming experiences currently available. The tale of Niko Bellic, and his drop into the murky underworld of Liberty City, was enough all on it’s own to be an absolute must buy. But a wide open world and some fantastic online gaming helped urge us to award the game a full 10 score when we reviewed the original. In fact, head over to read our initial review to get caught up on the basics before carrying on. This PC release of Rockstar’s latest epic only reminds of just why all these high scores and awards have been lavished on this multi-million selling title. But, it also gives the opportunity to revisit a game that unfortunately did suffer from a handful of flaws that could just prevent it from being fondly remembered in years to come. Firstly, Niko’s story may be fairly lengthy, packed with detail, and an enjoyable ride. But, there’s little doubt that the freedom we’d all hoped for simply isn’t there. Missions are tightly structured, with anything more than minute deviation from the set path only helping in forcing you to fail this latest task. And the lack of mid-mission checkpoints is still horrifically frustrating. Similarly, the land of Liberty City wasn’t fleshed out as fully as we’d craved. While a stunning backdrop to enjoy as you progress through the games huge storyline, or as you simply cause merry hell for the cities unfortunate inhabitants, there simply wasn’t enough to do. Instead of feeling as if you’re witnessing a huge city just waiting to be explored and tinkered with, GTA IV’s Liberty City is little more than a pretty backdrop. Flaws to the title aside – all of which are still firmly included here as this isn’t much more than a port of the console originals – this is still the Grand Theft Auto IV that millions have loved and enjoyed. And now it’s available for PC owners to see just why all those console owners fell in love. For PC owners, there’s the usual slight nudge upwards in terms of graphical splendour if you’re packing a particularly healthy gaming rig. Ignore the auto settings that the game detects for you as they will inevitably be way too optimistic and have a half hour tinker to get everything running smooth as silk. For us even the perfect settings still seemed to stutter when the action really starts to heat up. Irritating, but even so, Liberty City will still astound as it is such an incredibly beautiful game world. The biggest addition for YouTube fans is the replay editor. Prod your F2 key and the last 30 seconds of GTA action will be stored on your hard drive, just waiting to be edited, set to some kind of horrific rawk soundtrack, and uploaded and pimped around gaming forums the world over. It certainly gives much more scope to the ability to go crazy wild in Liberty City when you can create some stunning clips to show off to your gaming chums. That’s not all. You know that huge mass of music stored on your hard drive? Well you now have your own music station where you can play a selection of your favourites. It might not sound an astounding feature, particularly when the variety of stations, music and banter on offer in game is quite impressive, but it definitely helps the excitement levels when a classic tune drops as you’re cruising the highways. The fantastic multiplayer is much the same as the console versions, with one very noticeable difference. Instead of up to 16 spots for online gamers, that number has now doubled to 32, allowing you the opportunity for much larger, more hectic, and overall far more exciting multiplayer experiences. A fantastic inclusion. Verdict It’s the same old GTA IV, with a few additions tossed into the mix. With a patch now (almost) obliterating the early bugs that stopped a large number of users even initialising the game, this one is absolutely essential for PC gamers. Time has helped show off a few flaws in proceedings – hence the drop to a score of 9 – but this is still worthy of all those awards and high scores it’s been showered with. To echo our original review, buy it, play it, experience it.[Sensitivity of bacteria causing urinary tract infections towards terizidon (author's transl)]. In agar diffusion tests 2603 bacterial strains of species known to cause urinary tract infections were tested routinely in regard to their sensitivity towards Terizidon, a derivative of cycloserine. In order to relate the results which were obtained in terms of the diameter of the inhibiton zone, to the minimal inhibitory concentrations (MIC), 304 of these strains were tested additionally in agar dilution tests. The MICs of the other strains were estimated from the results of these tests. Since it is known that after the oral administration of 500 mg Terizidon the urine contains, on average, more than 128 mug/ml Terizidon for 12 hours and longer, it may be concluded from the results of this investigation that 75% of the strains of E. coli and Citrobacter, 45% of enterobacter, 40% of Proteus mirabilis and enterococci, 35% of the indole-positive Proteus strains and 30% of Pseudomonas aeruginosa would have been successfully attacked by Terizidon in the case or urinary tract infections. By contrast, Klebsiella must be reagarded as being completely resistant to this antibiotic. It follows that the administration of Terizidon is mainly indicated in the treatment of acute urinary tract infections with E. coli as the predominant causative agent.List of Jay Jay the Jet Plane episodes This is a list of episodes of the television series Jay Jay the Jet Plane. Episode consistency depends on the order: one episode says that the character Snuffy has not flown further away from Tarrytown than Lightning Bug Lake, but other episodes show him flying much further; in "Catch the Buzz" Snuffy still has not got rid of his original shyness, but in many other episodes he shows no sign of shyness. Series overview {\| class="wikitable" \|- ! style="padding: 0px 8px" rowspan="2" colspan="2" \| Season ! style="padding: 0px 8px" rowspan="2" \| Episodes ! style="padding: 0px 80px" colspan="2" \| Originally aired (U.S. dates) ! style="padding: 0px 8px" rowspan="2" \| Original network \|- ! First aired ! Last aired \|- \| style="background-color: #f03; color: #100; text-align: center; top" \| \| style="text-align: center; top" \| [[List of Jay Jay the Jet Plane episodes#Season 1 (1998)\|1]] \| style="text-align: center; top" \| 12 \| style="text-align: center; top" \| \| style="text-align: center; top" \| \| style="text-align: center; top" rowspan="2" \| TLC \|- \| style="background-color: #90b; color: #100; text-align: center; top" \| \| style="text-align: center; top" \| [[List of Jay Jay the Jet Plane episodes#Season 2 (1999–2000)\|2]] \| style="text-align: center; top" \| 14 \| style="text-align: center; top" \| \| style="text-align: center; top" \| \|- \| style="background-color: #FFD200; color: #100; text-align: center; top" \| \| style="text-align: center; top" \| [[List of Jay Jay the Jet Plane episodes#Season 3 (2001)\|3]] \| style="text-align: center; top" \| 14 \| style="text-align: center; top" \| \| style="text-align: center; top" \| \| style="text-align: center; top" rowspan="2" \| PBS Kids \|- \| style="background-color: #ffffff; color: #100; text-align: center; top" \| \| style="text-align: center; top" \| [[List of Jay Jay the Jet Plane episodes#Jay Jay's Mysteries series\|4]] \| style="text-align: center; top" \| 10 \| style="text-align: center; top" \| \| style="text-align: center; top" \| \|} Pilot series Television series Main series Season 1 (1998) Season 2 (1999–2000) Season 3 (2001) Jay Jay's Mysteries series The Mystery of Plants The Mystery of Weather The Mystery of Size and Shape The Mystery of Flight The Mystery of the Five Senses The Mystery of Water The Mystery of Bugs The Mystery of Time The Mystery of Stars and Planets The Mystery of Dinosaurs Jay Jay The Jet Plane episodes list ofMr. Perry introduced the following
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34, 15, 3015, 32835, 31238, 253, 1180, 273, 3038, 591, 2129, 326, 247, 11214 ]	and 402 of the Pharmacy Act place limitations on pharmacies, but they do not specify which pharmacies. A reading of these statutes to hold that the Puerto Rico Secretary of Health may inspect out-of-state pharmacies or that a pharmacist in another state must reside in the town where he is practicing or that an out-of-state pharmacist may only be absent from his pharmacy during the times set forth in section 402 would read these sections to be an unconstitutional attempt to regulate commerce outside the borders of Puerto Rico. See Healy, 491 U.S. at 336, 109 S.Ct. at 2499; Brown-Forman Distillers, 476 U.S. at 582-85, 106 S.Ct. at 2086-87; Edgar, 457 U.S. at 641-43, 102 S.Ct. at 2640-41; K-S Pharmacies, 962 F.2d at 730-31. The Puerto Rico Supreme Court has recognized that a state may exercise jurisdiction only over persons and things located within its territory. Pueblo v. Contreras, 95 J.T.S. 161, 402 n. 1 (1995); Toro Ruiz v. Junta de Libertad Bajo Palabra, 93 J.T.S. 120, 11033 n. 2 (1993); Medina v. Tribunal Superior, 104 P.R.Dec. 346, 348, 4 Official Translations 483, 486 (1975). Therefore, this Court concludes that the Puerto Rico Supreme Court would read the provision in section 396 on inspections by the Secretary of Health, in section 401 on the pharmacist's town of residence, and in section 402 on hours when the pharmacist must be present at the pharmacy to refer only to "establishments" or "pharmacies" in Puerto Rico. Accordingly, the Court holds that these provisions are not applicable to the management and operation of National's business in New Jersey. These provisions cannot be used to prevent National from servicing customers in Puerto Rico. Because the Court holds that these provisions, as construed in this opinion, do not apply to National, the Court need not address at this time National's argument that the provisions constitute an undue burden on interstate commerce. Accordingly, this argument is denied without prejudice. The conclusion that these laws should only apply to pharmacies in Puerto Rico and not to National's operations is supported by a second reason. The Pharmacy Act was enacted in 1945; the statutes which created the Colegio took effect in 1938. See 1945 Laws of Puerto Rico No. 282, at 998-1034, May 15, 1945; 1938 Laws of Puerto Rico No. 243, at 458-63, May 15, 1938. Although the laws have been amended over the years, they have not been substantially changed, at least not in any way relevant to the present controversy. It is evident from the language of the statutes that they were not enacted with mail-order pharmacies in mind: nowhere is there any mention of them. This is not surprising, given the fact that mail-order 60 pharmacies a la National's operations did not exist at the time these statutes were originally enacted.[24] Based on a reading of the laws as a whole and on their historical context, it is apparent that Puerto Rico's pharmacy laws were drafted with the intention of regulating and licensing only those pharmacies that were operated and located in Puerto Rico. National's recourse, then, is to seek a license from the Secretary of Health and to register with the Board of Pharmacy. The Court recognizes that the Puerto Rico pharmacy laws do not specifically provide for mail-order pharmacies. This is an oversight which can be readily corrected. The statutes and regulations of a number of states offer a wide range of examples on how to deal with this industry. In all, at least thirty-eight states have enacted measures on mail-order pharmacies. See Ala. Code § 34-23-31; Alaska Stat. § 08.80.158; Ark.Code Ann. § 17-92-401; Cal.Bus. & Prof.Code § 4112; Colo.Rev. Stat.Ann. § 12-22-130; Conn.Gen.Stat. Ann. §§ 20-627 to 20-630; Del.Code Ann. tit. 24, §§ 2538 - 2540; Fla.Stat. ch. 465.0156; Haw.Rev.Stat. § 461-15; Idaho Code §§ 54-1743 to 54-1748; 225 Ill. Comp.Stat. 85/16a; Ind.Code. § 25-26-13-17; Iowa Code § 155A.13A; Kan.Stat.Ann. § 65-1657; Ky.Rev.Stat.Ann. § 315.0351; La.Rev.Stat.Ann. §§ 2702 - 2704; Me.Rev. Stat.Ann. tit. 32, §§ 13721, 13751; Md. Code Ann., Health Occ. § 12-403; Mich. Comp.Laws § 333.17748; Minn.Stat. § 151.19; Miss.Code.Ann. § 73-21-106; Mo.Ann.Stat. § 338.337; Mont.Code Ann. § 37-7-703; Neb.Rev.Stat. § 71-2407; Nev.Rev.Stat. § 639.2328; N.M.Stat.Ann. § 61-11-14.1; N.C.Gen.Stat. § 90-85.21A; N.D.Cent.Code § 43-15-34.1; Or.Admin.R. 855-041-0300; S.C.Code Ann. § 40-43-83; S.D. Codified Laws §§ 36-11-19.2 to 36-11-19.9; Tenn.Code Ann. § 63-10-410; Tex. Health Code Ann. 4542a-1; Utah Code §§ 58-17a-102 & 58-17a-303; Va.Code Ann. § 54.1-3434.1; Wash.Rev.Code §§ 18.64.350 to 18.64.400; W.Va.Code § 30-5-6a; Wyo.Stat.Ann. § 33-24-152. A provision on mail-order pharmacy may be as simple as a single administrative regulation. For example, Oregon's administrative rules require simply that any mail-order pharmacy shall be registered with Oregon's Board of Pharmacy, be registered in good standing in the state where it is located, and designate one of its pharmacists to be responsible for all prescriptions delivered to Oregon residents. Or.Admin.R. 855-041-0300. Missouri has a statute which is similarly concise. It requires only that any out-of-state pharmacy be licensed with Missouri's board of pharmacy. Mo.Ann.Stat. § 338.337. Other states have more complex requirements. Nevada mandates that any mail-order pharmacy be licensed with the state board; that it also be licensed in the state where it is located; that it comply with all federal laws and regulations; and that it submit evidence that its facility and records comply with the laws of the state where it is located. Nev.Rev.Stat. § 639.2328. California requires that every out-of-state mail-order pharmacy register with the California board of pharmacy; provide the names of its agent for service of process in California, its pharmacists, and its corporate officers; comply with the pharmacy laws of the state where it is located; keep records of all controlled substances or potentially dangerous drugs dispensed to California customers; and maintain a tollfree 61 telephone service to allow for communications between California patients and pharmacists at the mail-order pharmacy. Cal.Bus. & Prof.Code § 4112. Delaware, Iowa, and Kansas all have statutes with requirements comparable to those of California's, including that for a toll-free telephone number for customer questions. Del.Code Ann. tit. 24, §§ 2538-2540; Iowa Code § 155A.13A; Kan.Stat.Ann. § 65-1657. The Court, of course, makes no judgment as to which of the variety of state statutes would best enable Puerto Rico to regulate mail-order pharmacy.[25] The Court holds only that the challenged provisions in sections 396, 401, and 402 that a prescription for a Puerto Rico patient may only be filled by a pharmacist residing in the town where his pharmacy is located, that a pharmacist must be present at the pharmacy he manages for a specified number of hours per week, and that any pharmacy be subject to inspections by the Secretary of Health do not apply to pharmacies outside of Puerto Rico and, so construed, do not unconstitutionally burden interstate commerce. Declaratory judgment shall be entered to this effect. National's proper recourse is to seek licensing and registration from the appropriate Puerto Rico authorities. And because the above-mentioned provisions of sections 396, 401, and 402 do not apply to out-of-state pharmacies, National may not be denied a license or registration on the grounds that it does not comply with these provisions.[26] WHEREFORE, the Court denies without prejudice National's challenge to the constitutionality of the above-discussed statutes regulating the practicing of pharmacy in Puerto Rico. Declaratory judgment shall be entered holding that the provision of 20 L.P.R.A. § 396 requiring that a pharmacy be subject to inspections by the Secretary of Health, the provision of 20 L.P.R.A. § 401 requiring that a pharmacist reside in the town where his or her pharmacy is located, and the provision in 20 L.P.R.A. § 402 specifying the number of hours per week that a pharmac
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1665, 49375, 4845, 6043, 434, 29292, 275, 521, 9004, 360, 15, 6043, 2684, 1115, 2825, 327, 23860, 1665, 562, 273, 4709, 344, 651, 320, 44137, 604, 344, 858, 417, 15, 187, 805, 15, 36242, 1264, 3618, 2720 ]	the circuit court and the evidence in the record do not establish a sufficient connection between Tolson's tortious actions and his work for the State. Appellants claim that Tolson's abuse of his authority to coerce Cravens and to sexually assault him cannot be deemed to have arisen out of Tolson's employment or to have been performed in connection with his official duties on behalf of the State. Appellants argue that the sexual assault of Cravens did not serve to benefit the State in any way and, therefore, cannot be deemed related to the employment. Interpreting a statute and determining whether it applies to a given set of facts are questions of law which this court reviews de novo. Boggs ex rel. Boggs v. Lay, 164 S.W.3d 4, 23 (Mo.App. E.D.2005). We must give effect to the language of a statute as written and will not add words or requirements by implication where the statute is not ambiguous. McCormack v. Capital Elec. Constr. Co., 159 S.W.3d 387, 402 (Mo.App. W.D.2004). "The plain language of [§ 105.711] provides coverage for conduct of an employee `arising out of and performed in connection with his or her official duties.'" Betts-Lucas v. Hartmann, 87 S.W.3d 310, 321 (Mo.App. W.D.2002). "The Fund is merely a voluntary assumption of defense and payment of judgments or claims against state employee (sic) sued for their conduct arising out of and performed in connection with official duties on behalf of the state." Dixon v. Holden, 923 S.W.2d 370, 379 (Mo.App. W.D.1996) ("Dixon I"). This Court has "expressly noted that there was no criminal conduct exception and the legislature, if it desired a policy favoring one, should reconsider the Fund statute."[2]Betts-Lucas, 87 448 S.W.3d at 321. Section 105.711 likewise contains no requirement that the employee be acting "in good faith" in performing the acts giving rise the underlying cause of action.[3]Dixon I, 923 S.W.2d at 379. The Legislature has not seen fit to amend the statute to include any such exceptions. Dixon I "made abundantly clear . . . a § 1983 claim for denial of constitutional rights under color of state law is covered in the State Legal Expense Fund, § 105.711.2." Dixon v. Holden, 963 S.W.2d 306, 307 (Mo.App. W.D.1997) ("Dixon II"). In the case at bar, the federal district court found that Tolson had violated Cravens's constitutional rights under color of law. In subsequently issuing its writ, the state circuit court found that Tolson was charged by the State with the care and custody of Cravens and that he had used the authority granted to him by the State to perpetrate the sexual assaults on Cravens. The circuit court even found that Tolson's acts were done, in part, as an official form of punishment for Cravens's violation of prison rules.[4] Under the foregoing findings of fact, Tolson's actions constituted conduct arising out of and performed in connection with his official duties. The circuit court did not misinterpret or misapply the law in concluding that the judgment against Tolson entered in the federal district court was covered by § 105.711. Point denied. In their second point, Appellants claim that the circuit court erroneously concluded that it was bound by the findings of the federal district court because they were not parties to that action and because the issue of whether § 105.711 applied was not fully litigated in that case. Appellants further argue that "[t]he federal court lacked jurisdiction to adjudicate whether an intentional sexual assault was conduct arising out of and performed in connection with an employee's official duties." In its judgment, the circuit court did conclude that the federal judgment was binding as to whether the Tolson's conduct was covered by the Legal Expense Fund. However, the circuit court also independently found that Tolson's conduct arose out of and was performed in connection with his official duties. Since we have already determined that the latter finding was proper, we need not consider whether the circuit court's impression of the binding nature of the federal court's findings was correct. As noted supra, when reviewing the judgment in a court tried case, this court must affirm under any reasonable theory supported by the evidence. Klokkenga, 200 S.W.3d at 152. Point denied. In their third point, Appellants claim that the circuit court erred in ordering them to pay the judgment entered against Tolson because any judgment against them was barred by the doctrine of sovereign immunity. Appellants contend that the language of § 105.726.1, RSMo Cum.Supp. 2005, providing that "Sections 105.711 to 449 105.726 do not waive the sovereign immunity of the State of Missouri," served to bar judgment against them in this case. "Sovereign immunity is a judicial doctrine that precludes bringing suit against the government without its consent. It bars holding the government or its political subdivisions liable for the torts of its officers or agents unless such immunity is expressly waived." State ex rel. Div. of Motor Carrier & R.R. Safety v. Russell, 91 S.W.3d 612, 615 (Mo. banc 2002). "Sovereign immunity, if not waived, bars suits against employees in their official capacity, as such suits are essentially direct claims against the state." Betts-Lucas, 87 S.W.3d at 327. Sovereign immunity is simply not applicable to this case. "The legislative provisions creating the Legal Defense Fund constitute[] `a voluntary assumption of defense and payment of judgments or claims against state employees sued for their conduct arising out of and performed in connection with official duties on behalf of the state.'" Id. at 327-28 (quoting Dixon I, 923 S.W.2d at 379). "[S]overeign immunity [is] not available as a defense by the State to actions seeking recovery from the [Legal Expense] Fund, given that the underlying litigation is against state employees, rather than the state itself." Id. at 320.[5] Nothing in the revised language of § 105.726.1 changes that fact. Point denied. In their final point, Appellants assert that the circuit court erred in awarding Cravens attorney's fees related to his mandamus action. They contend that such an award is not specifically authorized by statute and is, therefore, precluded under the State's sovereign immunity. In making this argument, Appellants ask us to overrule our holding in Dixon v. Holden, 963 S.W.2d 306, 308 (Mo.App. W.D.1997), approving a similar award of attorneys fees that were incurred in bringing a declaratory judgment action to collect payment of a judgment from the Legal Expense Fund. We decline Appellant's invitation to reconsider the reasoning of Dixon II. In Dixon II, the plaintiff obtained a judgment against two state employees under 42 U.S.C. § 1983 and, after the State refused to pay the judgment, filed a declaratory judgment action against the State Treasurer and Commissioner of Administration asking for a declaration that the State was responsible for satisfying that judgment from the Legal Expense Fund. Id. at 307. After obtaining such a declaration, the plaintiff filed an application for attorneys' fees expended in collecting on the judgment from the State. Id. In reversing the trial court's denial of that motion for attorney's fees, this Court noted that "Section 1988(b) of the Civil Rights Attorney's Fees Awards Act specifically allows a court to award the successful party attorney fees as costs in any action or proceeding to enforce rights claimed to have been denied under § 1983" and that "state courts may award attorney fees as costs pursuant to § 1988." Id. at 308. We held that the defendants were subject to an award of attorney's fees under § 1988 and that sovereign immunity did not shield them from such an award. Id. Appellants offer no reason to differentiate Cravens's application for attorney's fees in this mandamus action from *450 the application filed in the declaratory judgment action in Dixon II, and we perceive of no reason to treat them differently. The circuit court had the authority to enter an award of attorney's fees under § 1988, and sovereign immunity does not serve to bar such an award.[6]Id. Point denied. The judgment is affirmed. All concur. NOTES [1] In its judgment, the U.S. District Court found, in relevant part: 4. Defendant Tolson was employed by the Department of Corrections as a food service cook at Algoa, during the time Plaintiff was incarcerated at Algoa. 5. As part of his duties, Tolson, supervised the inmate line cooks that worked in Algoa's bakery. Tolson's supervisory duties allowed him to spend unmonitored time with inmates. 6. Plaintiff worked in the bakery at Algoa in February 2004. 7. Plaintiff was supervised in the bakery by Tolson. 8. On three occasions, Tolson engaged in forcible oral sex with Plaintiff during Plaintiff's work hours in the bakery. 9. Plaintiff did not consent to any of the episodes of oral sex. 10. Tolson used physical force, threats, and coercion in order to engage in oral sex with Plaintiff. 11. On two other occasions, Tolson forcibly placed Plaintiff's penis in his rectum. Plaintiff performed anal sex on Tolson out of fear he would be harmed if he did not. 12. Approximately three weeks prior
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247, 1270, 2968, 359, 1833, 1056, 352, 2464, 187, 187, 8, 8380, 1024, 2, 1422, 8138, 673, 5015, 4117, 2624, 275, 253, 45724, 48834, 15, 686, 4045, 368, 417, 27753, 326, 1110, 322, 15, 37, 15, 45417, 403 ]	worst headache to be faced was that it was still high summer. Aircraft dropping supplies for Resistance groups in Yugoslavia, or even Czechoslovakia, could leave after dark and return before dawn; but a trip to central Poland meant a five-hour flight each way and, allowing an hour for the pick-up, that meant that the aircraft could not leave Brindisi much after seven o'clock; so it would still be light enough for it to be spotted by German fighters when it passed over the northern Adriatic. A Dakota with additional fuel tanks had been laid on for the job, and at a conference next day it was decided to guard against possible interception by sending a Liberator to escort it on the first part of its journey. At the conference Gregory met the crew of the Dakota that was to fly him in. The Captain of the aircraft was Wing Commander Frencombe of No. 267 Squadron, the pilot Flight Lieutenant Culliford, the navigator Flight Lieutenant Williams, the W/T operator Flight Sergeant Appleby, and a Polish Flying Officer, K. Szaajer, from the Polish Flight had been seconded to act as interpreter if necessary. Everything had been made ready to carry out the operation that night but the Met. report was unfavourable, so with keyed-up nerves they waited to see if the next day would bring an improvement. It did, so on the evening of the 25th they made their final preparations. Soon after seven o'clock they went out on to the airfield. A last check-up was made on the Dakota KG.447 then, clad in windproof clothing and wrapped in rugs to keep them as warm as possible during their long cold journey, at 19.37 hours they took off. While over the Adriatic they were spotted by German patrol-boats that carried anti-aircraft guns, but were flying sufficiently high to escape the flak that was loosed off at them. By half past eight they were over Yugoslavia and a little before ten o'clock when they were approaching Budapest, darkness having fallen, their escorting Liberator turned back and left them. With a steady hum the Dakota soughed on over Hungary and Czechoslovakia. For a good part of the flight Gregory slept, then half an hour after midnight Flight Lieutenant Williams roused him to tell him that they were approaching their destination. The aircraft was steadily coming down from the great height at which it had been flying, so he took off his oxygen mask and went forward into the cockpit. To check the features of the country far below with the map was anything but easy, as there were patches of drifting cloud that now and then obscured the moon for up to two minutes at a time, and when the moonlight did glint on water the whole of the area to the north-east of Warsaw was so intersected by the rivers Liwiec, Bug and Narew, with their many tributaries, that Gregory began to fear that he would not be able to identify the two forks between which lay Malacou's cottage. For some fifteen minutes he and Williams peered down, sweeping the landscape with powerful night glasses, then the Flight Lieutenant said, 'We've overshot it. We must have by now,' and told the pilot to turn back. The aircraft heeled over as Culliford brought her round. Just as he straightened out a pair of searchlights suddenly came into action away to the west and in wide arcs began to sweep the sky. As the Captain of the aircraft muttered a curse another pair opened up to the south, then a third pair almost immediately below them. It was evident that the German listening posts had picked up the sound of their engines. The pilot banked the aircraft, then put her into a steep dive. As Gregory righted himself from a lurch Williams shouted to reassure him. 'Our trips over Poland are so infrequent that there's a good chance they'll take us for one of theirs that has got off course. Unless they catch us in a beam and identify us as an enemy they won't shoot.' Culliford had brought the aircraft down to five hundred feet, so it was now well below the angle at which the searchlights were sweeping. Two minutes later Gregory heard Malacou's voice as clearly as though he had been in the 'plane, calling, 'Here! Here! Come down! Come down!' Staring earthward he suddenly recognised the bend in the big river near which the cottage lay, then the road to Rózan some way to the north of it. Putting one hand quickly on the pilot's shoulder, he pointed downward with the other. Culliford nodded, turned the aircraft in a wide sweep and shut off his engine. Slowly she sank, then, bumping only slightly, taxied to a halt on the long straight road that ran through the marshes. Gregory, Williams and Szaajer scrambled out and looked quickly about them. A cloud had just obscured the moon again, but next moment they spotted a torch being flashed at intervals some quarter of a mile away. While the three of them ran towards it the others remained in the aircraft so that if need be it could make a quick getaway. As they approached, the flashes from the torch ceased and they all drew their pistols in case they were walking into a trap. But Gregory went forward confidently, because for several hours past, except during his sleep in the aircraft, he had been concentrating on letting Malacou know that the pick-up was to be that night, and the occultist's clear call to him, only five minutes earlier, confirmed that his telepathic communication had been received. The moon suddenly came out again and two figures emerged from a patch of tall reeds at the roadside. Malacou stepped forward and cried joyfully, 'Mr. Sallust, I knew that I could not be mistaken, and that you were on your way. It is a great relief that you have got here safely.' He then introduced his companion as the Polish engineer Mr. Kocjan. When Gregory had introduced the others Kocjan, also speaking German, pointed at the searchlight beams and said quickly, 'Now that they have lost the sound of your engines they will know that the 'plane must have come down, and may suspect that it is British. It might have landed several miles from here, so there is no cause for panic. But, all the same, we must not lose a moment. Come; follow me.' Turning, he led them at a loping run along a winding path fringed by tall fields of reeds and occasional patches of water. Ten minutes later they reached the cottage. The windows were blacked-out, but an oil lamp was burning in the living room and Gregory saw that two men dressed in rough farm clothes were silently waiting there. As they came to their feet, Kocjan said: 'These are two of my brave fellows. There are many packages to carry to the 'plane so I wish I could have collected more men, but this was the best I could do at such short notice.' Malacou, still breathing heavily from having had to run, stepped over to the stove and said, 'I thought that after your long flight you would be half frozen; so I have here some soup for you.' Pouring the steaming liquid into three bowls, he handed them to Gregory, Williams and Szaajer. 'It's very welcome,' Gregory smiled, and Szaajer broke off a conversation he had started with the two farm workers to bow his thanks. But Kocjan said abruptly, 'Drink quickly, please. We shall need every hand.' Then he signed to his helpers and they followed him out of the room. While Gregory sipped at the scalding soup, Malacou confirmed in words the misfortunes that had befallen him during the past six months, giving a brief version of the thoughts he had conveyed by telepathy. As soon as they had finished he led them outside and round to a woodshed at the back of the cottage. It was lit by another oil lamp and Gregory saw that the two farm workers had already left with a first load. But Kocjan was there and the hunchback Tarik, who was helping him load a packing case on to a low, two-wheeled truck. Beyond them lay a pile of at least a score of roughly made crates and bundles. As Gregory's glance fell on them, he exclaimed uneasily in German: 'Good God, what a mass of stuff! If all that pile contains metal parts they must weigh a ton.' 'No, nothing like it,' grunted the Pole. 'It is the awkward shape of many pieces that makes them appear so bulky, and several of the cases contain documents we succeeded in stealing in a raid we made on a German headquarters. They may prove valuable, although not in the class of the rocket. We managed to prise off the tail, so have the whole works and have reason to be proud of our achievement.' 'You certainly have,' Gregory agreed. 'I'm only wondering if the aircraft can take it all. She's fitted with additional fuel tanks, of course; but she needs every gallon for her fourteen-hundred-mile flight here and back.' Then he turned to Williams and asked him in English what he thought. The Flight Lieutenant shrugged. 'We have room enough for it, but there's more of it than I expected. If he is right about the pieces not weighing a great deal we'll make it.' 'Come now! You waste time talking,' cut in the Pole angrily. 'Do you not realise that those S.D. swine are
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3477, 5487, 15, 418, 20100, 13, 17373, 11736, 253, 7016, 32199, 665, 574, 4962, 285, 1669, 617, 3815, 13, 574, 5262, 247, 1175, 2968, 273, 673, 2403, 2119, 703, 3260, 849, 281, 6016, 5972, 672, 13699, 15, 1500, 1537, 417, 320, 2104 ]	reminded him, sidling toward the armory door. "I'm protected by Anothosia as long as I carry the baby." "You trusted me after the protection was cast," Pol said. "That makes me immune. Now, darling, it's no use looking at the door. You'll never get it unbarred in time, and you might as well forget trying to stab me with a sword. The enjoyable thing about my kind of chameleon is we aren't bothered by steal." Straightening, he lifted the sword. "I wish I could say I'm sorry, but I can't. I like you well enough, but I've a pleasant job to do and no conscience at all. I can't even promise this will be quick since I like playing with my toys." "Me, too," Elise said when she felt the door's bar press into her back. Reaching up, she grasped Wynderfyte and pulled the war hammer down from its supports. She dropped the knife from her left hand and reached up to grasp a shield. Shifting her fingers, she adjusted her grip on the hammer's shaft and wished she had leisure to slide her arm through the shield's arm strap. As it was, she could only grasp the shield by its center handle, making her hold of it awkward. "We never practiced with a hammer," Pol pointed out. His eyes laughed at her naivety, mocked her, and then he lunged in for an attack. He struck high, low, and then tried to slice the artery under her arm. Frightened, Elise ducked and dodged. She twisted free of one blow, caught one on the shield, and another struck Wynderfyte's metal shaft, sending up a rather unimpressive shower of sparks. "I know," Elise replied, and she swung Wynderfyte with all the fear she possessed. The hammer struck Pol's sword, almost sweeping it from his hand. "You should have found yourself a shield," she added helpfully. "This hammer might be a tad bit slow, but your pointed stick is far too light to block me." Nervous sweat ran into her eyes, blurring her vision and making her eyes sting. Risking a quick swipe with her shield arm's sleeve, she wished she had a rag to tie around her head. "I'm still immune to steel," Pol pointed out. His hooded eyes appeared amused and contemptuous. Laughter bubbled lightly on his lips, "Still, you are right. Your hammer is very slow." His arm flickered and fire ran along Elise's ribs. She gasped, stumbled, and prayed to Anothosia for her child's life. Pol struck again and yet once more. He moved with a speed and flexibility he had never shown her before. Elise caught two strikes on her shield, twisted to avoid another, and then the thin steel blade slashed into her left thigh before she could leap away. She cursed, glanced down, and saw she bled from a gash. "Pity you won't live," Pol observed. "The cut would have made a wonderfully ugly scar." "It won't be my first," Elise panted. She hurt in more places than she should, which meant she bore more wounds than she knew. It was only a matter of time before she became too weak to defend herself. Already, her leg trembled and threatened to give way. "Oh?" Pol raised an inquisitive eyebrow. "My father," Elise said, "insists all his children have some taste of war." Stepping forward, she swung Wynderfyte with all her might. Pol moved to block, but Elise slammed her wooden shield into him, and the hammer cracked into Pol's left shoulder. Pol cursed, stumbled, and fell back, his shoulder a ruin. Feeling grim satisfaction, Elise followed. "There's a difference between iron and steel," she said with a grin. "Olnac made himself king with this weapon because he was too poor to afford a sword." She swung again and cursed her weak arm. The hammer was heavy, and she had already lost too much blood. Pol's sword deflected her slow strike, but she slammed into him with her shield once more. The shield shivered in her hand when it hit his defending arm, almost falling from her weak grip, but Elise maintained control. She struck once and then twice with shorter and weaker war hammer blows. The heavy iron glanced off Pol's head to crack into his injured shoulder once more. Crying out, he staggered back, stopped, and lunged forward just in time to meet the hammer once again. Wynderfyte crushed flesh and bone beneath its unforgiving weight. Sweat streaming down his face and blood running from a tear in his scalp. Pol swayed before her, unsteady, broken, one eye fallen free from a crushed socket. Realization and despair bled from his remaining eye as Pol opened his fingers, the sword falling from his slack grip. "I was right when I said you have a warrior's heart," Pol whispered, and then Elise swung Wynderfyte with all the remaining strength she possessed, using her legs and back to amplify its force. Wynderfyte crashed into his face, breaking his jaw, sending jagged shards of broken teeth flying through a mist of blood. He fell, but Elise did not stop swinging. The hammer cracked into Pol again and again, breaking his body beneath its weight until, exhausted, Elise fell to her knees and the hammer slipped from her hand. She stayed there, swaying while she searched within herself for some promise the king's unborn heir still lived. Peace settled over her and warmth. Her mind wandered, opened, and Anothosia's grace momentarily filled her soul. Dripping blood slowed, stopped, and Elise's ripped flesh healed. New strength filled her. A muted and insistent pounding sounded on the thick oak door. Rising, Elise felt no surprise at finding her shredded dress was clean and whole. Not a drop of blood stained it, not a wrinkle showed, but she still had blood on her hands. "Why?" Elise asked the air. "Calto," Anothosia answered within her mind. The pounding stopped and the ring of axes on wood started. Elise listened while watching Pol's features shift. The remnants of his handsome mien became coarse and disjointed. Below the ruin of his inhuman face lay a misshapen body with almost no unbroken bones. Looking down on her work, Elise smiled. Not even the gods of Hell could reform this body. She had made sure of it. If Pol were to live once more, Zorce would have to form him a new body, a spawn's body, for Pol's spirit was not strong enough to claim anything more. Though he had played her for a fool, he had been a fool to believe the gods of Hell would grant him strong life and great strength for dying while failing to fulfill their will. Finally, the crack of weapons and tools on the door ceased when the door broke open. Men bearing weapons poured in, but their weapons lowered among a united sound of startled gasps. King Vere stepped past the gathered guards, stared first with unbelieving eyes at Pol before he turned those eyes on her. "How? How could you do this?" he demanded. "This is murder." "This is justice," Elise lied. "He tried to rape me, and I became angry." She gave her husband a long, studying stare before allowing one corner of her lips to form a partial smile. "I've decided on a name for your heir. We'll call him Olnac, after your grandfather, because he knew iron sometimes has more worth than steel." "Murder," her husband whispered, but his voice shook. They both knew the charge could not stand. Pol Swordbreaker was obviously hellkind. No court in all of Yernden would convict any of its citizens for killing one of Zorce's followers. Not now. Not yet. Knowing this, Queen Elise allowed her smile to become full, bright, and without concern. She leaned over to grasp Wynderfyte's handle, straightened, and lightly rested her other blood smeared hand on her husband's corpulent cheek. "Try to divorce me," she whispered, gently patting him, "and watch me really get mad." Fastening her eyes on Belsac's scowling face, she narrowed her eyes. Then she laughed. Chapter 11— A Matter of Forgiveness Anithia straightened her tunic and grasped Missa's hand tighter while quickstepping her way home from brood-mother Kali's, the only safe place she had found to leave her daughter while she worked. Looking around, she tried to wear her 'don't fuck with me' attitude, but with her feet thudding dully on the cracked boardwalk and her mouth twitching nervously, she knew she failed. They passed a young pickpocket who made a laughing comment to two friends before he leered at her breasts and made an obscene gesture, indicating exactly what he would like to do to her. Mouth dry, Anithia touched her knife's comforting handle before narrowing her eyes and staring back, letting him know she was nobody's easy victim. Larson, gods bless the sorry bastard who had died and left her alone, had spent a good deal of time making sure she knew how to handle herself when threatened. She might not be able
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12583, 50270, 357, 35461, 1099, 187, 50276, 2415, 57, 14, 19, 50266, 51, 12815, 50275, 5902, 50265, 21173, 44348, 50274, 2925, 2222, 2526, 187, 50276, 51, 3246, 2082, 50266, 24431, 50274, 25797, 15, 25, 35, 883, 15, 20, 37, 26, 50275, 21173, 44348, 50274, 46, 2925, 3439, 1619, 187, 50276, 48876, 283, 18, 50266, 51, 12815, 50275, 5902, 50265, 29166 ]	outgrowing cells after plating of sheet 1\. sheet 30,000 BSS, balanced salt solution; CFHE, calcium-free Hank's EDTA; DMEM, Dulbecco's modified Eagle's medium; P, postnatal day; RT, room temperature; N/S, not stated. \ = incubation of the whole eye in protease with subsequent dissection (globe) or dissection of the eye and incubation of sclera, choroid and RPE sheet in proteinase (sheet) with or without retina, or incubation of the RPE layer with or without retina. \\ = yield per eye ball. \\\* = Pinzon-Duarte et al. ([@B66]) did not culture RPE cells but isolated the retina with intact attached sheets of RPE cells. \\\\ = Wang et al. ([@B85]) and Kreppel et al. ([@B48]) did not isolate RPE cells for extensive culturing but to test virus infection or to use the cells for biochemical assays, respectively. To achieve a more reliable method and a higher yield from adult rats, we systematically developed and validated a new way to isolate RPE cells. Our protocol is fast, easy and efficient and would provide a valuable tool for the study of AMD and other diseases involving RPE pathology. Our culture method of rodent adult RPE cells is based on the digestion of the whole eye in papain. We demonstrated the success of the culturing protocol using two-month old rat eyes. However, the method is widely applicable to other animals, such as mice, with slight modifications. The protocol provides a useful RPE cell culture model which can be used to evaluate the behavior of adult RPE cells when subjected to certain stresses in vitro, giving a result more reminiscent to the disease situation. Also, the cultured cells can be transplanted directly in common animal models of retinal degeneration such as the Royal College of Surgeon's (RCS) rat. We assessed our method by comparing cell yield, growth characteristics, the expression of RPE markers and the adhesion of the cells to Bruch's membrane components to previous data reported in the literature. Materials and Methods {#s2} ===================== RPE Cell Culture {#s2-1} ---------------- All animal work was carried out in accordance with the UK Animals (Scientific Procedures) Act 139 (1986) and within UK Home Office regulations. Animal experiments and designs were covered under Project licence 80/2360 approved by the Home Office. Adult Lister Hooded or Sprague Dawley (SD) rats (Charles River; 250--300 g, 8--10 weeks) were used for tissue. The rats were kept in standard housing conditions with 12 h light/dark cycle in a temperature-controlled room (22°C) with free access to food and water. A detailed step-by-step guide to the process is illustrated in Figure [1](#F1){ref-type="fig"} Rats were culled by exposure to rising concentration of CO~2~ followed by dislocation of the neck. Eyes were dissected out, and excess muscle and connective tissue were removed in ice cold phosphate-buffered saline (PBS). The eyes were then incubated in a 20 U/ml papain solution (Worthington PDS Kit) for up to 1 h at 37°C in a 24-well-plate. Four eyes can be placed in one well of the plate, and 1 ml of the papain solution should cover all eyes. Afterwards, eyes were transferred to DMEM supplemented with 10% fetal bovine serum (FBS) to stop the papain digestion. Using a needle (21 gauge, BD Microlance), a hole was introduced close to and an incision was made along the ora serrata to remove the lens and cornea-iris. The earlier digestion with papain allowed the retina to be pulled out readily, leaving the choroid-sclera complex behind. At this point, the RPE cells were still attached to the retina. The retina/RPE complex was further digested in 1 ml of fresh 20 U/ml papain for \~10 min at 37°C. By means of fine forceps, the RPE sheets were peeled off the retina. The sheets were incubated in trypsin (1 mg/ml in PBS, Sigma) and then triturated to achieve smaller patches of RPE cells. The trypsin cell solution was diluted with Dulbeccos modified Eagles medium (DMEM) supplemented with 10% FBS and washed through centrifugation. RPE cells (different cell numbers, see below) were plated on matrigel-coated (BD Biosciences; 1:80 in ice-cold DMEM and then incubated overnight at 37°C) culture dishes in "Miller" medium (DMEM supplemented with 20% FBS, N1 medium supplement, MEM-non-essential amino acids, 2 mM GlutaMAX^™^-I, 250 μg/ml taurine, 20 ng/ml hydrocortisone, 13 ng/ml triiodothyronin and antibiotics; Maminishkis et al., [@B56]; Sonoda et al., [@B74]). The next day, the medium was changed to "Miller" medium supplemented with only 5% FBS. Medium was changed twice a week. ![Dissection of retinal pigment epithelial (RPE) cells using papain.* First, rats were sacrificed using CO~2~ and dislocation of the neck. Then, eyes were dissected out, placed in phosphate-buffered saline (PBS) and excess connective tissue and muscle attachments were removed. Afterwards, the whole eye was incubated in papain (20 U/ml, Worthington PDS Kit) for up to 1 h at 37°C. The papain digestion was stopped by the addition of DMEM supplemented with 10% fetal bovine serum (FBS). Using a needle, a hole was introduced into the globe near the ora serrata, and the anterior part of the eye was cut away (following the red dotted line). Afterwards, the retina was carefully removed, and the choroid-sclera sheet was discarded. The RPE cells were still attached to the retina (pigmented cells in figure). The retina was then incubated for another 10 min in papain (20 U/ml) to loosen the RPE sheets which were then peeled off and incubated in trypsin (1 mg/ml) and triturated to achieve a single cell solution. Finally, the RPE cells were plated in "Miller" medium (DMEM supplemented with 20% FBS, N1 medium supplement, MEM-non-essential amino acids, 2 mM GlutaMAX^™^-I, 250 μg/ml taurine, 20 ng/ml hydrocortisone, 13 ng/ml triiodothyronin and antibiotics) on matrigel (1:80 in DMEM)-coated dishes.](fncel-09-00449-g0001){#F1} Immunochemistry {#s2-2} --------------- Animals were perfused transcardially with 4% paraformaldehyde (PFA, Sigma) in 0.1 M PBS, pH 7.2--7.4, after an overdose of general anesthetic \[Euthatal (200 mg/ml solution, Rhône-Mérieux)\]. Eyes were dissected out, and lens and anterior chamber were carefully removed together with the vitreous humor. Care has to be taken to not destroy or detach the retina. The eyes were immediately post-fixed in 4% PFA overnight at 4°C. The tissue was transferred into 30% sucrose (Sigma) in PBS, for cryoprotection. Sections of 14 μm thickness were cut on a cryostat (Cryostat Leica CM 3050S) and mounted on glass slides (Superfrost^®^ Plus, VWR). The sections were washed three times with PBS. Subsequently, the tissue was permeabilized and blocked using PBS supplemented with 0.3% Triton-X 100 (Vector labs; PBST) and 10% donkey serum (Sigma; PBST-S) for 1 h at room temperature (RT). Afterwards, sections were incubated in primary antibody solution (antibody diluted in 5% PBST-S (Table [2](#T2){ref-type="table"}) overnight (\~14--16 h) at 4°C. The next day, sections were washed three times for 5--10 min each with PBST followed by the addition of secondary antibody solution (Alexa488- or Alexa568-coupled donkey anti-rabbit or donkey anti-mouse (Invitrogen) diluted in PBST-S). After 1--2 h of incubation at RT, the tissue was incubated for 5 min in PBS supplemented with HOECHST-33342 (2 μg/ml, Sigma) to stain for nuclei. Afterwards, the sections were washed again three times for at least 10 min with PBST. Finally, the sections were sealed with a coverslip using Fluorosave^™^ (Calbiochem). ###### Primary antibodies used. Antigen Host Clone Supplier Product Code ---------------- -------- -------------- ------------ -------------- Basigin Rabbit EPR4052 Abcam ab108317 Collagen IV Rabbit pc\* Abcam ab19808 CRALBP Mouse B2 Novus NB100--74392 Cytokeratin 18 Mouse C--04 Abcam ab668 Fibronectin Rabbit pc Sigma F3648 Laminin Rabbit pc Sigma l9393 MERTK Rabbit pc Abcam ab95925 OTX-2 Rabbit pc Millipore AB9566 RPE65 Mouse 401.8B11.3D9 Millipore MAB5428 ZO--1 Rabbit pc Invitrogen
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15292, 636, 5048, 15, 187, 187, 3220, 2793, 27, 187, 187, 1147, 2335, 479, 374 ]	of Forge. Forge is like gauntlet, except you draft your deck out of a random selection of cards, in a fashion you will feel familiar with if you played Hearthstone’s Arena or Duelyst’s Gauntlet before. A key difference with the above is that in Eternal, you get to keep the cards you pick for your collection! Another important thing you need to know about Forge is that you will only be given choices from two factions, based on the first picks you make. This means that you can “force” the factions you need cards in. I invite you to do just that for Rakano, which also happens to be a strong faction pairing for limited formats anyway! The makings of a solid Rakano deck (regardless of budget) Before we actually start the Forge run, a few words about what the deck we’re aiming for looks like. There is more than one way to build a good Rakano deck. Today we’ll focus on the most common aggro archetype, commonly referred to as “pants” (due to its heavy use of weapons). It’s a relatively simple to play style of deck which is both very effective and easy to build across a wide budget range. Without naming specific cards, and with of course a fair amount of leeway on the numbers in each category to accommodate for specifics and techs, the deck will typically break down like this: 8 to 12 one-cost units 10 to 14 two-cost units 0 to 6 three-cost units 10 to 14 one or two-cost weapons (“cheap pants”) 4 to 8 three+ cost weapons (“fancy pants”) 4 to 10 Removal spells, tricks, or relics 25 or 26 Power As you can see, this is clearly an aggro deck, with a curve very low to the ground. It is built to make sure that you are most likely to fully utilize your mana on turns 1-4, quickly building a board of threats. Your opponent should immediately be on the back foot, and their slow draws will be punished hard. We play almost no cards that cost more than 3, so we can afford to play the minimum amount of power thanks to the mulligan rule (which guarantees you at least 2 power cards if you redraw your starting hand). The power should include as many duals as possible (both seats and banners) as well as Diplomatic Seals when you get them, and possibly a few Monuments to taste. I personally like two copies of Emerald Monument. In each category, there is a fair amount of leeway in what to use; the deck will function whether you have 4 copies of each best in slot rares (when there is even one) or a bunch of disparate commons, which is fortunate because we’ll have to do with the latter for a while. The reason I’m giving you these categories and approximate numbers for them rather than simply decklists is that, while it is entirely possible to craft most of the lower rarity stuff you need early on, it’s inefficient in terms of growing a collection – so we’ll try to avoid it as much as possible. Between the large packs, cards in chests, and limited modes letting you keep cards, Eternal gives out a whole lot of those low rarity cards. You’ll get full playsets of them very quickly! The flip side of that is that the crafting/recycling rates on them is very disadvantageous. With that in mind, I believe the best budget decks are those made out of whatever you have, rather than out of “cheap crafts”, which are actually the worst investment you can make. We will get to crafting eventually, but only after getting as many “free” cards as possible to make a base deck out of. Card rankings per category OK, so now you are ready to start your first forge run to populate that future deck of yours. But what do you pick? You already know to make your first picks either Justice (green) or Fire (red), but which cards are good? Well, here’s a handy table to answer that question! Anything on top of each of these categories should be a priority pick. In Forge, you only get picks of similar rarity at any given time, so you don’t need to “rare-draft”; only go for higher rated stuff. The exception is you’ll sometimes be given the choice of a Legendary over rares; unless the rare is high up in this table and the legendary looks lame, I say take the legendary in that the case. If you’re referring to this table in the context of drafting, it’s better to give some amount of priority to rares over C/Us. Common or Uncommon can be used as a tie-breaker in case you’re unsure between two picks, but should not matter that much otherwise. My experience: I got lucky with being given two Shogun’s Scepter, which are excellent spoils. I also secured a couple of Rakano Outlaw and Brightmace Paladin along with a few usable weapons. I did not manage to go all the way, losing game 4 to mana flood and then game 6 to a crazy series of plays by Vengeance. Still, one gold chest is good enough, especially when you’re lucky like me and it contains a Sparring Partner (another score !). First outing on the ladder! Congratulations on now having a semi decent deck ! It’s time for it to leave the nest now. Click that “ranked” button and battle away ! Don’t worry too much, it’s okay to lose. Maybe you’ll win some too, but even if you don’t you’ll certainly learn some things. Depending on the timing, you might find yourself in “unfair” match-ups with high ranked players rocking well tuned decks, so sweating over losses is really unnecessary. On the other hand, don’t just dismiss those losses as irrelevant either – note what’s killed you and what you maybe could have done better. My experience: The deck I was able to piece together for ladder looked like this: Baby’s First Rakano (example) This ragtag pile managed a very respectable 3-2 record, losing only to a very potent Stonescar curve-out and a Party Hour deck that looked like it belonged in Masters (or possibly in Nerf-land, but that’s another topic). First Draft After you completed your 5 placement games and collected your reward, you should have somewhere around 4,000 gold in the bank. You need 5,000 to buy your way into Draft, which is by far the most efficient way to grow your collection and also your next objective. I advise you to grind the last few gold coins you need in Gauntlet, as it’s an easier, less stressful environment to do so than the ranked ladder. It’s an opportunity to continue practicing with your deck too. Once that’s done, it’s time for you to discover one of the best things about Eternal: drafting! It’s a limited mode somewhat similar to Forge, but PvP, and actual packs being passed along (just like physical MtG drafting but asynchronous so you can take all the time you want) rather than 1-out-of-3 picks. Drafting is an art that is worth a whole series of guides on its own, and I’ll leave that to people more skilled at it than I am. Know that while that’s not always the best option, you can also “force” factions in draft. You can’t actually influence what cards you get passed, but you can decide to pick cards in the factions you want. That’s not always optimal for a bunch of reasons, most notably possible signals that someone up the line is already drafting the same factions, but we can choose to ignore those in the name of strategically advancing our collection. Note that Rakano is a strong choice for draft anyway, so you’re not gimping yourself much either. Just like with forge earlier, I invite you to peruse the previous table as a guideline. Prioritize picks on top of each category. Technically it would be better to use a draft specific picking guide (and you’re welcome to do that if you have one handy) but since we’re also trying to get cards for our deck the above will do just fine. There are however two things not in that table you should look out for : Legendaries or good rares(even off-color) : just pick those. You draft more cards than can fit in your deck, so you can afford to dedicate a pick to scoring a card you want for later. bombs and removal : (yes, BREAD) draft is often a slower format than constructed, so relatively high cost, high impact stuff will definitely win you games. Notably: rares like Rolant’s Honor Guard Silverwing Commander Fourth-Tree Elder Renegade Valkyrie Torch Vanquish Once your picks are done, take the best 28-29 cards out of there, add 16-17 sigils – assuming you went by the above, your curve should be low – and get out there! *Disclaimer : the above does not make a good replacement for a proper drafting guide ! Use one of those for your next run, or ask for help on the ever helpful Discord channel. My experience: It took me 2
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They were asked to clear their schedules until the end of July and would be compensated $12,500 for the adventure — with the opportunity to earn more. Bachelor in Paradise returns later this summer on ABC./* -- Mode: java; tab-width: 8; indent-tabs-mode: nil; c-basic-offset: 4 -- * * *** BEGIN LICENSE BLOCK *** * Version: MPL 1.1/GPL 2.0 * * The contents of this file are subject to the Mozilla Public License Version * 1.1 (the "License"); you may not use this file except in compliance with * the License. You may obtain a copy of the License at * http://www.mozilla.org/MPL/ * * Software distributed under the License is distributed on an "AS IS" basis, * WITHOUT WARRANTY OF ANY KIND, either express or implied. See the License * for the specific language governing rights and limitations under the * License. * * The Original Code is Rhino code, released * May 6, 1999. * * The Initial Developer of the Original Code is * Netscape Communications Corporation. * Portions created by the Initial Developer are Copyright (C) 1997-1999 * the Initial Developer. All Rights Reserved. * * Contributor(s): * Norris Boyd * Igor Bukanov * Bob Jervis * Roger Lawrence * Steve Weiss * * Alternatively, the contents of this file may be used under the terms of * the GNU General Public License Version 2 or later (the "GPL"), in which * case the provisions of the GPL are applicable instead of those above. If * you wish to allow use of your version of this file only under the terms of * the GPL and not to allow others to use your version of this file under the * MPL, indicate your decision by deleting the provisions above and replacing * them with the notice and other provisions required by the GPL. If you do * not delete the provisions above, a recipient may use your version of this * file under either the MPL or the GPL. * * *** END LICENSE BLOCK *** / // API class package org.mozilla.javascript; import java.lang.reflect.; import java.util.Hashtable; import java.io.; import org.mozilla.javascript.debug.DebuggableObject; /* * This is the default implementation of the Scriptable interface. This * class provides convenient default behavior that makes it easier to * define host objects. * <p> * Various properties and methods of JavaScript objects can be conveniently * defined using methods of ScriptableObject. * <p> * Classes extending ScriptableObject must define the getClassName method. * * @see org.mozilla.javascript.Scriptable * @author Norris Boyd / public abstract class ScriptableObject implements Scriptable, Serializable, DebuggableObject, ConstProperties { /* * The empty property attribute. * * Used by getAttributes() and setAttributes(). * * @see org.mozilla.javascript.ScriptableObject#getAttributes(String) * @see org.mozilla.javascript.ScriptableObject#setAttributes(String, int) / public static final int EMPTY = 0x00; /* * Property attribute indicating assignment to this property is ignored. * * @see org.mozilla.javascript.ScriptableObject * #put(String, Scriptable, Object) * @see org.mozilla.javascript.ScriptableObject#getAttributes(String) * @see org.mozilla.javascript.ScriptableObject#setAttributes(String, int) / public static final int READONLY = 0x01; /* * Property attribute indicating property is not enumerated. * * Only enumerated properties will be returned by getIds(). * * @see org.mozilla.javascript.ScriptableObject#getIds() * @see org.mozilla.javascript.ScriptableObject#getAttributes(String) * @see org.mozilla.javascript.ScriptableObject#setAttributes(String, int) / public static final int DONTENUM = 0x02; /* * Property attribute indicating property cannot be deleted. * * @see org.mozilla.javascript.ScriptableObject#delete(String) * @see org.mozilla.javascript.ScriptableObject#getAttributes(String) * @see org.mozilla.javascript.ScriptableObject#setAttributes(String, int) / public static final int PERMANENT = 0x04; /* * Property attribute indicating that this is a const property that has not * been assigned yet. The first 'const' assignment to the property will * clear this bit. / public static final int UNINITIALIZED_CONST = 0x08; public static final int CONST = PERMANENT\|READONLY\|UNINITIALIZED_CONST; /* * The prototype of this object. / private Scriptable prototypeObject; /* * The parent scope of this object. / private Scriptable parentScopeObject; private static final Slot REMOVED = new Slot(null, 0, READONLY); static { REMOVED.wasDeleted = 1; } private transient Slot[] slots; // If count >= 0, it gives number of keys or if count < 0, // it indicates sealed object where ~count gives number of keys private int count; // cache; may be removed for smaller memory footprint private transient Slot lastAccess = REMOVED; // associated values are not serialized private transient volatile Hashtable associatedValues; private static final int SLOT_QUERY = 1; private static final int SLOT_MODIFY = 2; private static final int SLOT_REMOVE = 3; private static final int SLOT_MODIFY_GETTER_SETTER = 4; private static final int SLOT_MODIFY_CONST = 5; private static class Slot implements Serializable { static final long serialVersionUID = -3539051633409902634L; String name; // This can change due to caching int indexOrHash; private volatile short attributes; transient volatile byte wasDeleted; volatile Object value; transient volatile Slot next; Slot(String name, int indexOrHash, int attributes) { this.name = name; this.indexOrHash = indexOrHash; this.attributes = (short)attributes; } private void readObject(ObjectInputStream in) throws IOException, ClassNotFoundException { in.defaultReadObject(); if (name != null) { indexOrHash = name.hashCode(); } } final int getAttributes() { return attributes; } final synchronized void setAttributes(int value) { checkValidAttributes(value); attributes = (short)value; } final void checkNotReadonly() { if ((attributes & READONLY) != 0) { String str = (name != null ? name : Integer.toString(indexOrHash)); throw Context.reportRuntimeError1("msg.modify.readonly", str); } } } private static final class GetterSlot extends Slot { static final long serialVersionUID = -4900574849788797588L; Object getter; Object setter; GetterSlot(String name, int indexOrHash, int attributes) { super(name, indexOrHash, attributes); } } static void checkValidAttributes(int attributes) { final int mask = READONLY \| DONTENUM \| PERMANENT \| UNINITIALIZED_CONST; if ((attributes & ~mask) != 0) { throw new IllegalArgumentException(String.valueOf(attributes)); } } public ScriptableObject() { } public ScriptableObject(Scriptable scope, Scriptable prototype) { if (scope == null) throw new IllegalArgumentException(); parentScopeObject = scope; prototypeObject = prototype; } /* * Return the name of the class. *
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644, 2183, 23499, 2069, 15, 48601, 5946, 45593, 457, 84, 1984, 5841, 281, 2564, 20681, 15319, 457, 84, 41116, 3085, 29219, 313, 12731, 582, 534, 12668, 247, 256, 1851, 615, 24627, 715, 253, 364, 14381, 474, 13, 2516, 24008 ]	or you get material way, way beyond what you already know. It's like a bomb going off, where you have to work very hard, mentally and physically, to absorb what is being taught and to understand the point of view. Then you start thinking about it in the context of what you already know, and you start wondering if you're on the right path... and if you are, how things should be changed to fit the information you've just assimilated. Ultimately, you may or may not end up adopting whatever the "bomb" type seminar showed you, but it does, for a while, impact how you think about your own art. I think that's a good thing - I think we need this sort of challenge once in a while. I usually leave this sort of seminar physically tired but mentally completely fried. THE COAST This is the kind of seminar where you don't learn anything new. You might think this sort of thing is a waste of your time, but really, here's something you can do if you find yourself coasting. I like to use this sort of seminar to work on my instruction skills. If I already know the content, I try my best to make sure I pair up with people who are very new to all of this (for them, this is a "Bomb" session, after all). I am careful to try to show exactly what the teacher at the seminar is showing the way he or she is showing it. It's my opportunity to hone my instructor skills and help a new person feel more welcomed into my art. THE FINE TUNE This camp is where you work on what you already know but in a way where you understand it better. It's comfortable, like coasting, but it's also a challenge and you learn a lot, like the bomb going off. It's like rotating a famous sculpture to see a side you don't normally see, or reading an analysis of a favorite book that points out nuances you haven't noticed before. This is a really important kind of seminar. It's the kind of session where you move beyond the surface of what we're taught in the earlier stages of our training. I usually leave this sort of camp energized and feeling creative. Where did this material come from? Oh yeah, sensei went to a seminar... Are there other kinds of camps or seminars than what I've described? Let me know in the comments!Amidst the hyper-capitalist spectacle of Frieze 2018, the political turmoil of the last year, and on the day before Brett Kavanaugh’s controversial and much-contested confirmation, legendary photographer Nan Goldin took to the stage with veteran arts writer Linda Yablonsky to discuss her career. Goldin is famously one of the most fearless photographers of her generation – with work that examines the deeply nuanced relations between ‘coupling’ of all degrees. From relationships that veer between fear and obsession, to individuals in a complex relationship with their own self-presentation, Goldin’s work has always delved into the rich tapestry of our own humanity. Her appearance forced a re-consideration of her landmark practice, in the context of a modern world that though plagued with political unrest has at least made leaps and bounds in the context of queer representation – of which Goldin was a torch-bearer, realising the vast array of aesthetic and emotional identities that could be caught on camera under the focus of her lens. “The instance of photographing, instead of creating a distance, is a moment of clarity and emotional connection for me.” This was clear in each moment of her conversation with Yablonsky, who carefully guided the conversation through a cast of characters – many of whom are now historically renowned; Robert Mapplethorpe, David Wojnarowicz, Cookie Mueller, and other luminaries of New York on the cusp the AIDS epidemic, which would cut short so many of their brilliant lives. Writing on the iconography and rhetoric of the AIDS epidemic — and the “epidemic of signification” that occurred as result — Susan Sontag assessed that “the catastrophe of AIDS suggests the immediate necessity of limitation.” This accompanied, in part, the observation of multiple socio-cultural breakdowns; the conflation of medical fact and social fiction, the sensationalising impact of moral panic upon the media, the effect of hysteria upon imaging the disease — and how these were fuelled careless reporting, pre-existing homophobia, and governmental complacency. In a time of cultural confusion, ‘fake news’, and the breakdown of public discourse over multiple crises of socio-political injustice, Goldin’s work remains as relevant today as it has ever been. The talk began with Nan Goldin at Frieze 2018 highlighting to the audience the presence of a striking series of medicinal bottles on the table, one for each life that would be lost to the American Opioid crisis during the course of her one-hour talk. This is her latest cri de coeur, and one through which she has suffered directly (as has always been the case with her work.) Writing of her own struggle with opioid addiction, Goldin acknowledges she “narrowly escaped […] I went from the darkness and ran full speed into the world. “I was isolated, but I realised I wasn’t alone. When I got out of treatment I became absorbed in reports of addicts dropping dead from my drug, OxyContin. I decided to make the private public […] my first action is to publish personal photographs from my own history.” As such, she has led an international campaign against the Sackler family – prescription drug dynasty and noted patrons of the arts – described by the New York Times as “the family that built an empire of pain.” In again tying her work to an epidemic of physical injustice and its emotional consequence, Goldin continues to forge ahead with a photographic practice that is deeply entrenched in her own personal politics – and in the bravery it takes to make the personal public in the name of political progression. We should all be grateful for her fearlessness, and the humility and honesty with which she rages on. “Memories of childhood humanize us as adults. With age, our version of that time is deformed then reassembled. What fragments bleed through are tailored to a narrative designed to hide vulnerability.” -P.K., And Every Day Was Overcast If the absence of vulnerability is a hallmark of adult self-retrospection as the first three lines of Paul Kwiatkowski’s debut novel, And Every Day Was Overcast, suggests, then the candid recollections of book’s protagonist, P.K., certainly break the mold. The narrator’s willingness to cast aside vulnerability in the service of brute honesty is all too evident as he recounts the ten years of his youth spent in Loxahatchee, Florida during the 1990s. P.K.’s youthful exploits are told in such nerve-bearing detail that not much is left to the imagination. Take, for example, P.K.’s account of how he willingly exposed himself to a drifter to score alcohol for him and his friends. Another section of the book describes how P.K. witnessed an acquaintance commit a random act of cruel violence against the school outcast, then abandon the victim’s unconscious body outside a 7-Eleven. The friendless, unfortunate boy, named Cobain, is never to be seen or heard from again, leaving the P.K. to ruminate in remorse through the course of his young adult life. “Worse than my guilt and fear was the relief I felt” laments P.K. “I told myself that his evaporation was a small death that had brought him to a better place.” Yet another passage from the book describes the 40 hours of court-ordered community service P.K. spent under the wing of an HIV-positive ex-drag queen named Cody, who introduces him to the secret lives of supposedly straight, well-to-do yuppy men who cruise for sex in drive-in theater parking lots and dingy gas station bathrooms in their off-hours away from work and home. Such are the types of memories many would try to bury as far into the depths of their psyche as possible. Instead, they are brought to light by the narrator in a graphic novel that reads like a yearbook from one of the most dysfunctional high school experiences imaginable. Kwiatkowski’s Florida is more than just the sunny, resort-ladden getaway destination its tourism department would have one believe. Its magic and charm are certainly not lost on the author, though both take a form that is much less that of the Disney variety. The author admits it took him leaving the state to fully realize just how much Florida’s topography influenced his adolescent experiences, though he’d always had it in the back of his mind that the state functioned on a plane quite different from other places. “I grew closer to the Bahamas and Jamaica than I did Georgia” says Kwiatkowski, who is currently based in New York. “So I think when you grow up in that cultural landscape you’re aware that you’re a little bit distant from the rest of America.” Shows like America’s Most Wanted, which Kwiatkowski says never ceased to showcase Florida’s pedophiles, rapists and murders, only helped to validate the author’s suspicions about the Sunshine State. Narratives like the vignettes found in And Every Day Was Overcast have been told countless times. Kwiatkowski’s book calls to mind Larry Clark’s seminal film Kids (1995), which drove a slegde hammer into the whimsical, John Hughes
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254, 15099, 558, 988, 186, 31484, 2946, 15, 53, 522, 32876, 8475, 9, 11707, 60, 17, 1570, 17229, 15, 21972, 57, 13, 4759, 60, 17, 1570, 17229, 15, 58, 559, 1384, 558, 11866, 186, 31484, 2946, 15 ]	members that left the games industry are working on films. Some are at tech companies like Google, Apple, and Tesla. A few have even worked as illustrators for children’s books. After Uncharted 2 shipped, Pope decided to go back to making the experimental games he got started with. He moved to Japan, closer to the family of his wife, fellow developer Keiko Ishizaka. In 2013, Pope released the critically-acclaimed Papers, Please. He has continued to make small games, and in 2018 put out Return of the Obra Dinn, which won grand prize at the Independent Game Festival Awards. A few Uncharted 2 staffers, like lead environmental artist Teagan Morrison, have left the games industry completely. Morrison, born in the UK, got his start making websites before moving to making 3D art and selling it online. Naughty Dog was a “dream job” for Morrison but he couldn’t legally work in the United States yet. The day his family got a green card, he sent in an application. After working constantly for two weeks on an environment test and going through interviews in which he was “sweating buckets,” Morrison was hired in 2006. After working as an environment artist on the first Uncharted, Morrison was made a lead for the sequel. He later became a lead technical artist, where he helped manage the vast amount of artists at Naughty Dog. Once Uncharted 4 released, Morrison decided to leave and help start Sky Castle Studios, which makes products like Hero Forge, a custom miniature service. Film and television have also attracted multiple people from Naughty Dog. Justin Richmond, game designer for Uncharted 2 and director of 3, co-founded the multi-media company Wonderstorm and co-created the Netflix show The Dragon Prince. Another person to go into film was concept artist Andrew Kim. Kim got his start working at game developer Pandemic in 2002, but jumped between films and games over the next few years. Near the end of his work as a concept artist on God of War 3, Kim’s friend Hong Ly told him Naughty Dog was hiring, and in 2008 he joined. After a few years, towards the end of development of Uncharted 3, another friend told him Marvel was looking for concept artists for its movies. “It was one of those opportunities I couldn’t resist,” he said. Kim worked as a senior concept artist for almost 3 years. After having a fourth child in 2014, Kim left and went freelance. Since then he has worked on various projects, including working as a freelancer on Uncharted 4, and on television shows like Star Trek: Discovery. While this article focused on Uncharted 2, these kinds of stories can be seen across the games industry. Thousands and thousands of people work hard to make the games we play, and every one has their own story. AdvertisementQ: Force linking against Python release library in debug mode in Windows/Visual Studio from CMake I'm developing a Python binding for a C++ library using Boost Python, for Linux and Windows (Visual Studio). In Windows, the static Boost Python library has a dependency against Python (this is motive for another thread, here), so, in my CMake config I need to do: if((${CMAKE_SYSTEM_NAME} STREQUAL "Linux") OR APPLE) target_link_libraries(my_python_module ${Boost_LIBRARIES}) elseif(WIN32 AND MSVC) add_definitions(/DBOOST_PYTHON_STATIC_LIB) target_link_libraries(my_python_module ${Boost_LIBRARIES}) #This includes the Boost Python library # Even though Boost Python library is included statically, in Windows it has a dependency to the Python library. target_link_libraries(my_python_module ${Python_LIBRARIES}) endif() This works fine in Linux, but in Windows, it only works in Release mode, not in Debug, in which case I always get a: LINK : fatal error LNK1104: Can't open file 'python37.lib' After some hair pulling I noticed the issue was caused by CMake instructing Visual Studio to link against 'python37_d.lib' instead of 'python37.lib' in the Debug mode. However, as I described in the linked issue, the officially provided Boost Python debug library is linked against the Python release library, not the debug one. So, the solution would be to force the link against the Python release library, regardless of the build type. Unfortunately, ${Python_LIBRARIES} sets the library automatically depending on the mode, and I wouldn't like to explicitly specify python37.lib in my code (since I can upgrade Python and I don't want to have to change my CMake scripts because of that). I found some similar issues here and here, but that doesn't reflect the exact situation I'm facing. Based on those, I tried setting: target_link_libraries(my_python_module optimized ${Python_LIBRARIES}) But that didn't work either. So, the question is: Is there a way to force the usage of the Python release library in Debug mode WITHOUT having to set it explicitly and leaving the Python CMake package to do it automatically instead. By explicit I mean doing: target_link_libraries(my_python_module python37) Thanks a lot for your help. A: It seems that set(Python_FIND_ABI "OFF" "ANY" "ANY") as suggested in the comments by kanstar would be the correct way to do this. However, while Python_FIND_ABI is in CMake master, it hasn't been released yet in the latest version (v3.15.2 as of this writing). In the meantime, there are solutions dependent on the CMake version. CMake 3.12 and above It's possible to link against FindPython's Python_LIBRARY_RELEASE, which isn't meant to be part of the module's public interface, but the variable is set correctly nonetheless. cmake_minimum_required (VERSION 3.12) find_package(Python ..<choose your COMPONENTS; refer to FindPython docs>..) if(WIN32 AND MSVC) target_link_libraries(my_python_module ${Python_LIBRARY_RELEASE}) endif() CMake 3.0.4 to 3.11 Thanks to a comment by @Phil, we can expand the answer to include earlier CMake versions which had the FindPythonLibs module that sets the PYTHON_LIBRARY_RELEASE variable instead. cmake_minimum_required (VERSION 3.0) find_package(PythonLibs ..<refer to FindPythonLibs docs>..) if(WIN32 AND MSVC) target_link_libraries(my_python_module ${PYTHON_LIBRARY_RELEASE}) endif() using System; using System.Collections.Generic; using System.Diagnostics; using System.Linq; using System.Text; using System.Threading.Tasks; using Xamarin.Forms; using Xamarin.Forms.CustomAttributes; using Xamarin.Forms.Internals; using Xamarin.Forms.Xaml; #if UITEST using Xamarin.Forms.Core.UITests; using Xamarin.UITest; using NUnit.Framework; #endif namespace Xamarin.Forms.Controls.Issues { #if UITEST [Category(UITestCategories.InputTransparent)] [Category(UITestCategories.Gestures)] [NUnit.Framework.Category(Core.UITests.UITestCategories.Github5000)] #endif [Preserve(AllMembers = true)] [Issue(IssueTracker.Github, 2858, "Transparency Cascading", PlatformAffected.Android)] public partial class Issue2858 : TestContentPage { const string Success = "Success"; const string Failure = "Fail"; const string InnerGrid = "InnerGrid"; const string OuterGrid = "OuterGrid"; #pragma warning disable CS0414 int _tapCount = 0; #pragma warning restore CS0414 public Issue2858 () { #if APP InitializeComponent (); #endif } #if APP void TapGestureRecognizer_OnTapped(object sender, EventArgs e) { _tapCount += 1; if (_tapCount == 1) { Result.Text = Success; } else { Result.Text = Failure; } } #endif protected override void Init() { } #if UITEST [Test] public void CascadeInputTransparentGrids() { RunningApp.WaitForElement(InnerGrid); RunningApp.Tap(InnerGrid); var green = RunningApp.WaitForElement(OuterGrid); RunningApp.TapCoordinates(green[0].Rect.CenterX, green[0].Rect.Y + 20); RunningApp.
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From the above verse it is substantiated that is nothing but due to illiteracy and ‘knowledgelesness’ of Qur’aan and Hadith. If Allah (Jal…) is conversing with a person it should be understood that He is Waliyullah. Allah (Jal…) has conversed with Imam Shazuli (Razi…) several times through (Ilhaam) mind. Shazzan Lee Named by Allah:Once Hazrath Imam Shazuli (Razi…) was giving lecture to his followers and people at Shazila. A lot of muridheens were gathered around him awaiting for the words which would come out from Imam.Imam’s speech was like the water coming out of a opened sluice. Imam Shazuli (Razi…) was telling about Allah (Jal…)’s favour towards us, our duty towards Allah (Jal…), our gratitude to be shown towards him and the relationship between the universal creator Allah (Jal…) and his human creations. Listening all this from the Imam the people felt as if they were standing before Allah (Jal…). Hazrath Imam Shazuli (Razi…) who gave speech with calmness heard a voice “Antha Shazzan – Lee”. Feeling that this voice is from Allah’s side, Shazuli Imam (Razi…) asked “Ya Allah! I am not from Shazila and then why am I called Shazuli”? “You are my most lovable”. You are with individuality and you are superior among my affectionate and hence the name (Shazzan Lee) replied Allah (Jal…). The number of muslims following Hazrath Imam Shazuli (Razi…) increased day by day. There were 125 thousand followers of Imam when he entered the Cairo city. From this we can know the integrity of Hazrath Sheikh Shazuli (Razi…). Hazrath Imam Shazuli (Razi…) built a madarasa by name “AL MADRASATUL KAMILIYYA” at Cairo city where AL – AZHAR UNIVERSTY is situated today. The knowledge of Imam Shazuli (Razi…) was explainable to the Malayikaths. Once, Imam Shazuli(Razi…) was traveling with Hazrath Abu Muhammadh Abdhullah Al Hasani (Razi…) towards a city Shazila. On the way Imam said “Oh Abu Muhammadh! you be standing there at that point you need not come in search of me”. Few minutes later Imam Shazuli(Razi…) felt uneasy, and he left his friend Hazrath Abdhullah . Suddenly some four large birds came down. That formed a queue and talked something with Imam one by one with reverence. Then a plethora of tiny birds came down and surrounded Imam. Later they all flied off.Imam asked “Oh! Abdhullah! Did you see any wonder?” Yes my Sheikh! I replied and briefed to Sheikh what I saw, and asked for its meaning.Imam replied “The four large birds were the Celestial beings (Malaks). They had a doubt and came to me for explanation and they returned with satisfaction”. The numbers of tiny birds were the soul of Waliyullahs who want to get prosperity by visiting me. Preceptor of Siddiqeens:-Allah (Jal…) ordered Imam Shazuli (Razi…) to go to Cairo to train up some 40 Siddiqeens spiritually. Imam too went and gave those Siddiqeens who are next to Nabis good advices. “An amallahu alaihim minan Nabiyeena Was Siddiqeena wash Shuhadhayi was Sualiheen”. “Whoever follows Allah and his Prophet, will be with those like Nabis (Messengers), Siddiqeens,Shuhadhaas and Sualiheens.Upon him Allah’s mercy is blessed, on the day of judgement. In this order it is found that Siddiqeens are prior to Shuhadhaas (Martyrs who were killed for the sake of Islam) from the above verse. Imam Shazuli (Razi…) had been a teacher to that kind of Siddiqeens! Subhaanallah! Shariath – bridle for foretelling – instance about Sheikh Shamsudheen Hanafi (Razi…):-“If the bridle called Shariath is not locked upon my mouth, I would tell you all, what is to happen till the day of Qiyamah” said the ocean of knowledge Hazrath Imam Shazuli (Razi…). But to prove this his statement He foretold an incident to his followers about the birth of Sheikh Shamsudheen Hanafi (Razi…). Talking to a big gathering at the Cairo city, Imam Shazuli (Razi…) lectured “Oh my people! Listen carefully to what I am conveying today. Exactly 100 years after me, a male child will originate at Egypt. He will be Reddish white in colour. There will be a mole at his right cheek which will beautify him. He will lose his parents at his early stage and his name is “Muhammadh” He will be called “Shamsudheen”, He will be a follower of Hanafi School. He will rejuvenate “Zaviya” my madarasa. This tariqa will be spread all over the world during his tenure as 5th Khaleefa of mine. His praise & familiarity will grow high”. Just as Imam Shazuli (Razi…) had foresaid, everything happened. People wondered and they felt proud about this incident, feeling Shazuli Imam (Razi…) as the real panacea of ever.Introducing coffee to the world:-During his earlier period Imam Shazuli (Razi…) had firm meditation at the Saffron hill. He spent 40 days fasting and 40 nights on prayers. Floral leaves and salt was the only food both for Sahar & Iftar. Sometimes Imam felt very tiresome and he was thinking about how to overcome this? At that time Allah (Jal…) showed coffee to Imam through some birds. Those tiny birds wandering during day time were praying and begging God at the night. But they were brisk anytime. Making note of this Imam Shazuli (Razi…) was very much surprised. He saw those birds sitting at a tree and taking some seeds. After eating the seeds,the birds were refreshed. Suddenly Imam collected those seeds and put it to the water and drank. What a surprise! All his exhausted-ness flied off and Imam Shazuli (Razi…) was fully brisk and refreshed. Historians write that was the first invention of coffee till today and we are using it similarly. So the pride of introducing coffee a good refresher goes to Imam Shazuli (Razi…).Zikr Jahri:-When Imam Shazuli (Razi…) was at the Zawiya of Cairo he introduced the open meditation. Sheikhs of other tariqas introduced a silent way of meditating God. Unlike other Sheikhs Imam Shazuli (Razi…) preached Zikr Jahri and there is an incident behind this. Hazrath Abu Muhammadh Abdullah who was there along with Imam while Sheikh Shazuli Imam (Razi…) was on firm meditation at the saffron hill for 40 days, narrates:I stayed there at the cave of saffron hill with Sheikh Shazuli Imam (Razi…) for 40 days. I could feel the rain of mercy of Allah (Jal…) lashing on Imam Shazuli (Razi…).”Man Kaanallahu kaana lahu kulli shaiyin”, “If a person turns himself for Allah, every matter turns for him”. As Hazrath Imam Shazuli (Razi…) was affectionate towards Allah (Jal…), according to the above Hadith, Allah made everything to turn to our Sheikh’s possession. One day during midnight after praying Tahajjudh, Hazrath Shazuli Imam was reciting Qur’aan. He was reciting surathul An’aam. When he crossed a verse “Wa in tha’dhil kulla Adhlil laa yookhaz minha” means “If Allah were to go ahead to punish all human for their misdeeds, then none will survive. But Allah (Jal…) deals with them with leniency and not catches hold his slaves (Human)”. Hazrath Shazuli Imam (Razi…) was very much joyous feeling the mercy of Allah (Jal…) and so he repeatedly recited the same verse. And his lips started pronouncing “Allah… Allah… Allah…” and as he entered a state of (Jazb) his voice grew and was in the high pitch to the extent the entire mountain shook in the direction his Holy body moved in Jazb. As Hazrath was moving up and down and at the sides, the mountain also moved vertically and horizontally the same way. This situation lasted for a while. Who ever heard that were attracted towards it
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The access to the career of Public Ministry magistrate obeys to the same previous conditions as the access to the careers of judges, also implying the graduation in the Centro de Estudos Judiciários. Barristers and solicitors The barristers (advogados) and solicitors (solicitadores) are the legal practitioners who represent the natural and legal persons before the courts and deal with other legal matters. The legal representation by a barrister is considered an essential element in the administration of Justice and is admissible in any proceedings. It can not be prevented before any jurisdiction, authority, or public or private entity. Both the professions of barrister and solicitor are statutory regulated and represented by public professional associations, respectively the Ordem dos Advogados (Order of the Barristers) and the Câmara dos Solicitadores (Chamber of the Solicitors). Being member of those professional associations is a mandatory condition for the practice of the professions of barrister or solicitor. The admission to the professional associations implies the previous graduation in Law (or alternatively having a solicitor's degree in the case of solicitors candidates), performing an internship and passing in access examinations. Officers of Justice The officers of Justice constitute the special class of public servants that serve in the secretaries of the courts and of the Public Ministry offices. Their roles include the providing of the administrative services of the Judiciary, the execution of warrants, the service of scrivener in the trials and the function of criminal police in the inquiries. The career of officer of Justice of the courts includes the categories of escrivão de direito (scrivener of Law), escrivão-adjunto (deputy scrivener) and escrivão auxiliar (auxiliary scrivener). Regarding the career of officer of Justice of the Public Ministry, it includes the categories of técnico de Justiça principal (principal technician of Justice), técnico de Justiça-adjunto (deputy technician of Justice) and técnico de Justiça auxiliar (auxiliary technician of Justice). See also Public Ministry Law of Portugal Judicial Studies Center Judiciary of Brazil Judiciary of Macau References * Court systemQ: Dataset is 20X slow when adding column heads I'm trying to use Dataset to explore some large data. I notice that the performance decrease more than 20X by adding heads to the columns. Here is an example: We generate some data with integers data = RandomInteger[{1, 100000}, {1000000, 7}]; convert it into a Dataset object ds1 = Dataset[data]; // AbsoluteTiming (* {0.000606, Null} ) and sort it according to the first column ds1[SortBy[#[[1]] &]]; // AbsoluteTiming ( {0.507638, Null} ) Now if we add the heads to the data head = "x" <> ToString[#] & /@ Range[7] ( {"x1", "x2", "x3", "x4", "x5", "x6", "x7"} ) ds2 = Dataset[AssociationThread[head -> #] & /@ data]; // AbsoluteTiming ( {4.57311, Null} ) Now sorting becomes 20X slower ds2[SortBy[#x1 &]]; // AbsoluteTiming ( {10.6259, Null} *) So why does the performance decrease when we add a header to our data? Is there a way to fix that? System information: version 11.1 on mac os 10.12.3 A: Your ds2 is a highly inefficient shape. Using 10 in place of 1000000 in the data code we get something like: (Observations made in Mathematica 10.1) ds2 // InputForm Dataset[{<\|"x1" -> 10, "x2" -> 4, "x3" -> 8, "x4" -> 3, "x5" -> 6, "x6" -> 5, "x7" -> 5\|>, <\|"x1" -> 2, "x2" -> 9, "x3" -> 6, "x4" -> 10, "x5" -> 10, "x6" -> 5, "x7" -> 1\|>, <\|"x1" -> 9, "x2" -> 6, "x3" -> 6, "x4" -> 10, "x5" -> 2, "x6" -> 10, "x7" -> 6\|>, <\|"x1" -> 8, "x2" -> 2, "x3" -> 2, "x4" -> 2, "x5" -> 6, "x6" -> 2, "x7" -> 8\|>, <\|"x1" -> 1, "x2" -> 8, "x3" -> 10, "x4" -> 3, "x5" -> 8, "x6" -> 3, "x7" -> 9\|>, <\|"x1" -> 3, "x2" -> 6, "x3" -> 1, "x4" -> 10, "x5" -> 3, "x6" -> 5, "x7" -> 8\|>, <\|"x1" -> 6, "x2" -> 7, "x3" -> 5, "x4" -> 2, "x5" -> 10, "x6" -> 4, "x7" -> 9\|>, <\|"x1" -> 7, "x2" -> 10, "x3" -> 8, "x4" -> 1, "x5" -> 3, "x6" -> 3, "x7" -> 8\|>, <\|"x1" -> 4, "x2" -> 3, "x3" -> 6, "x4" -> 1, "x5" -> 8, "x6" -> 5, "x7" -> 1\|>, <\|"x1" -> 8, "x2" -> 7, "x3" -> 8, "x4" -> 1, "x5" -> 3, "x6" -> 9, "x7" -> 10\|>}, TypeSystem`Vector[ TypeSystem`Struct[{"x1", "x2", "x3", "x4", "x5", "x6", "x7"}, {TypeSystem`Atom[Integer], TypeSystem`Atom[Integer], TypeSystem`Atom[Integer], TypeSystem`Atom[Integer], TypeSystem`Atom[Integer], TypeSystem`Atom[Integer], TypeSystem`Atom[Integer]}], 10], <\|"ID" -> 127397422492264\|>] Not only is this redundant but its form prohibits packing; every Integer is stored separately. Compare the Transpose of your ds2: ds2\[Transpose] // InputForm Dataset[<\|"x1" -> {10, 2, 9, 8, 1, 3, 6, 7, 4, 8}, "x2" -> {4, 9, 6, 2, 8, 6, 7, 10, 3, 7}, "x3" -> {8, 6, 6, 2, 10, 1, 5, 8, 6, 8}, "x4" -> {3, 10, 10, 2, 3, 10, 2, 1, 1, 1}, "x5" -> {6, 10, 2, 6, 8, 3, 10, 3, 8, 3}, "x6" -> {5, 5, 10, 2, 3, 5, 4, 3, 5, 9}, "x7" -> {5, 1, 6, 8, 9, 8, 9, 8, 1, 10}\|>, TypeSystem`Struct[{"x1", "x2", "x3", "x4", "x5", "x6", "x7"}, {TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10]}], <\|"Origin" -> HoldComplete[AssociationTranspose, Dataset`DatasetHandle[127397422492264]]\|>] Observe that not only is the representation more compact but the data is typed as vector arrays: TypeSystem`Vector[TypeSystem`Atom[Integer], 10]. Create your Dataset in the efficient shape to begin with to avoid a very slow Transpose operation: ds3 = Dataset @ AssociationThread[head -> (data\[Transpose])]; From here you can quickly apply a sort like this: ds3[[All,
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12123, 1302, 13, 347, 2006, 7872, 12121, 1912, 275, 253, 45845, 15, 329, 5266, 812, 320, 2668, 281, 253, 1986, 14726, 8801, 12484, 7039, 13, 533, 253, 7295, 812, 11823, 667, 6454, 432, 326, 1232, 1512, 15, 187, 187, 2773, 6505, 247, 1091, 281, 40140, 13, 534, 2006, 7872, 12121, 574, 3597, 323, 8007, 3786, 13, 1293, 2323, 15 ]	"signers":[{ "name":"signer1", "type":"pkcs12", "algorithms":["SHA256withRSA"], "caCerts":[], "key":"password=1234,keystore=file:keycerts/ocsp1.p12" }], "stores":[{ "name":"store1", "ignoreExpiredCert":true, "ignoreNotYetValidCert":true, "includeArchiveCutoff":true, "includeCrlId":false, "retentionInterval":-1, "minNextUpdatePeriod":"1d", "unknownCertBehaviour":"malformedRequest", "updateInterval":"10m", "source":{ "datasource":"datasource1", "type":"ejbca-db", "conf":{ } } }] } Effects of residual novaluron on reproduction in alfalfa leafcutting bees, Megachile rotundata F. (Megachilidae). The chitin synthesis inhibitor novaluron can suppress pests that affect alfalfa seed production, but can negatively affect reproductive success in the alfalfa pollinator Megachile rotundata. Novaluron is considered to be a reduced-risk insecticide because it disrupts ecdysis and is non-lethal to adult insects, but some exposed adults have fewer eggs and suppressed egg hatch. For this experiment, bees nested in field cages where they were exposed to alfalfa that had never been treated with novaluron, alfalfa that had recently been sprayed or alfalfa that had been sprayed 1 and 2 weeks earlier. Compared with the control, greater proportions of dead eggs and larvae and lower proportions of live prepupae occurred when bees were exposed to recent novaluron sprays as well as one- or two-week old spray residues. Two possible routes of residual pesticide exposure were revealed. Mother bees become contaminated through ingestion or direct contact, or pollen-nectar provisions become contaminated with novaluron (1) on or within leaf pieces that surround provisions or (2) transferred from mother bees' bodies to provisions. We found strong immature mortality effects of novaluron and its residues on M. rotundata. Understanding all possible pesticide exposure routes for pollinating bees enhances decision-making for maintaining bee populations while protecting crops. © 2016 Society of Chemical Industry.// Copyright 2013 The Chromium Authors. All rights reserved. // Use of this source code is governed by a BSD-style license that can be // found in the LICENSE file. #include "extensions/browser/api/system_cpu/cpu_info_provider.h" #include "extensions/shell/test/shell_apitest.h" namespace extensions { using api::system_cpu::CpuInfo; class MockCpuInfoProviderImpl : public CpuInfoProvider { public: MockCpuInfoProviderImpl() {} bool QueryInfo() override { info_.num_of_processors = 4; info_.arch_name = "x86"; info_.model_name = "unknown"; info_.features.clear(); info_.features.push_back("mmx"); info_.features.push_back("avx"); info_.processors.clear(); info_.processors.push_back(api::system_cpu::ProcessorInfo()); info_.processors[0].usage.kernel = 1; info_.processors[0].usage.user = 2; info_.processors[0].usage.idle = 3; info_.processors[0].usage.total = 6; return true; } private: ~MockCpuInfoProviderImpl() override {} }; class SystemCpuApiTest : public ShellApiTest { public: SystemCpuApiTest() {} ~SystemCpuApiTest() override {} void SetUpInProcessBrowserTestFixture() override { ShellApiTest::SetUpInProcessBrowserTestFixture(); } }; IN_PROC_BROWSER_TEST_F(SystemCpuApiTest, Cpu) { CpuInfoProvider* provider = new MockCpuInfoProviderImpl(); // The provider is owned by the single CpuInfoProvider instance. CpuInfoProvider::InitializeForTesting(provider); ASSERT_TRUE(RunAppTest("system/cpu")) << message_; } } // namespace extensions 26 F.3d 123 State Bank of India, New York Branchv.Personal Data Systems, Inc., On-Line Solutions, Inc., Brody(Steven), Szegda (Michael) v. Szegda (Michael),Rosen, Szegda, Preminger & Bloom NO. 93-1767 United States Court of Appeals,Third Circuit. Apr 14, 1994 Appeal From: E.D.Pa., Newcomer, J. 1 AFFIRMED. I support a supreme law, written constitution for Aotearoa New Zealand. The main reason for this is my view that human rights need significantly more legal protection in our country. In their book, A Constitution for Aotearoa New Zealand, Sir Geoffrey and Dr Butler refer to the vulnerability of New Zealand’s human rights law, which may be overridden by a bare Parliamentary majority.1 They also refer to the power of New Zealand’s Human Rights Review Tribunal to declare that a law is inconsistent with the human right to be free from discrimination. As they say, however, even when the Human Rights Review Tribunal makes this type of declaration, Parliament can decide not to change the offending law.2 One of the Human Rights Review Tribunal cases they refer to is Adoption Action Incorporated v Attorney-General.3 I think this case exemplifies why our current legal protections for human rights are insufficient, and why truly constitutional guarantees are necessary. Adoption Action Incorporated advocates for adoption law reform.4 After “years of unsuccessfully lobbying various ministers and government administrations”,5 on 22 July 2011 Adoption Action brought its case in the Tribunal. This was “a last resort to bring about change to the adoption law of New Zealand.”6 Adoption Action claimed that sections of the Adoption Act 1955 and the Adult Adoption Information Act 1985 breached the right to freedom from discrimination on the grounds of sex, marital status, sexual orientation, disability, age, and race. The Tribunal heard the case over a total of 10 days, in late 2013 and in early 2014. Over 2 years later, on 7 March 2016, the Tribunal issued its decision.7 It upheld almost all of Adoption Action’s claims, and declared that six sections of the Adoption Act, and one section of the Adult Adoption Information Act, were inconsistent with the right to freedom from discrimination. The Government could have appealed the Tribunal’s decision, but it did not. Accordingly, the Government had to bring the Tribunal’s declarations to the attention of the House of Representatives, and advise the House of its response to the declarations.8 As set out in the Human Rights Act, the Tribunal’s declarations did not affect the legal validity of the sections of the Adoption Act and Adult Adoption Information Act found to be in breach of the right to freedom from discrimination.9 Any change would have to be made by Parliament. In August 2016, the Minister of Justice Amy Adams tabled the Government’s response to the declarations in the House.10 The Minister advised that the Government did not agree with two of the Tribunal’s declarations, for reasons which had been considered and rejected by the Tribunal in its decision. There was no reference in the response to the five other declarations made by the Tribunal, other than recording that they had been made. The response stated that reforming the Adoption Act would require “significant resource reallocation”11 and referred to Government’s other legislative priorities. Nothing was said about the Adult Adoption Information Act. The response also stated the Government’s view that the Adoption Act is, in practice, interpreted in a rights-consistent manner. This was despite the Government having conceded before the Tribunal that any such practice does not make discriminatory law non-discriminatory.12 The response further advised that the Government will not, “at the present time”,13 rectify the ongoing breaches of fundamental human rights identified by Adoption Action and upheld by the Tribunal. This outcome shows how fragile New Zealand’s domestic human rights framework is. Under it, the Government may ignore declarations made by the statutory body Parliament has empowered to determine whether legislation breaches the human right to freedom from discrimination. The Government may do this after years of hard-fought litigation, which it has lost, in reliance on arguments which failed in that litigation. Despite a fundamental human right being at stake, there is no requirement for the House of Representatives to vote on what should be done, or even to debate it. And where to now for Adoption Action, or people affected by the discrimination? There is no point in going back to a New Zealand court, as Adoption Action won in the Tribunal. A petition could be taken to the United Nations Human Rights Committee, but the Government could ignore any outcome from that process too. That leaves a return to lobbying, which Adoption Action had tried for decades previously, without success.
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Is the tutorial / instruction mistaken? <OerHeks> maybe you need unity-tweak-tool for that, not sure <OerHeks> dbugger, ^^. as the system seetting do give themes, but not icon themes seperate <ycyclist> update-alternatives --set java /usr/local/java/jdk1.8.0_91/jre/bin/java update-alternatives: error: no alternatives for java <saitoh183_> im having a issue importing a 28mb db using phpmyadmin <saitoh183_> http://paste.ubuntu.com/19277184/ <saitoh183_> just get a blank page <joelio> saitoh183_: do you have php max size set or something in php.ini? <joelio> oh, that looks like an actual failure <Jack543> Hello! <soulez> Where in launchpad.net can I request a petition to add a feature in ubiquity installer to make possible install ubuntu in a preencrypted hard disk out of the box like fedora or centos installer, it is a very usefull option <saitoh183_> joelio: yes <dbugger> So I cant set the icons, with Unity? <saitoh183_> joelio: http://paste.ubuntu.com/19278449/ <xangua> dbugger: install unity tweak tool as you were told <dbugger> oh i have it already. let me see <dbugger> Indeed that did it <dbugger> thanks you! <joelio> saitoh183_: not fastcgi timeouts too.. php one part, but perhaps another part has timeouts set too <joelio> looks like it's being disrupted during load <joelio> but that could also be SQL that's making the parser b0rk <joelio> saitoh183_: have you managed to ingest that dataset ok locally <joelio> also, what's wrong with a <joelio> mysql -u blah -p < file.sql ? <joelio> (assuming cli access) <andrzej> joelio: if not CLI he can use this https://www.adminer.org/ one php file with mysql admin <Jack543> Hello! <Jack543> Developer C? <saitoh183_> joelio: i didnt try via CLI but i could <Pici> Jack543: if you're asking about programming in C, the channel is ##C <joelio> saitoh183_: yea, cli all the way, always going to be quicker than using http and interpretted languages to load mysql <saitoh183_> joelio: what would be the proper command? My sql file is in my home folder <joelio> mysql -u {username in database } -p < {path to mysql file} <joelio> the -p prompts for password <paranoidabhi> hi <joelio> the < is a shell redicrection <paranoidabhi> questoin: http://askubuntu.com/questions/795169/kde-slow-boot-on-kubuntu-16-04 <paranoidabhi> *question <paranoidabhi> please have a look. :) <paranoidabhi> I have posted it several times. <joelio> a 5400rpm HD isn't the quicket you know... <paranoidabhi> joelio, yeah but 2:30 is still way long <saitoh183_> joelio: ERROR 1046 (3D000) at line 29: No database selected do i have to create a empty db? <paranoidabhi> joelio, windows on dual boot takes 45 secs. <joelio> saitoh183_: ok, so add the db <joelio> mysql -u blah -p {database} < file.sql <Powerless> i am trying to send this line and it says connection refused. how to allow it? echo "test" \| ssh walluser@IP wall <paranoidabhi> I can't find anyway to fix it. I very tired finding solutions. Please suggest any relevant directions. <joelio> paranoidabhi: have you tried adding that module you say is faully (wifi or ethernet?) to a blacklist and see if it boots quicker <paranoidabhi> joelio, thanks for the suggestion. I haven't, can you suggest how I can do that. <joelio> paranoidabhi: yea, just checking for 16.04.. normall it's in /etc/modprobe.d/blacklist <tahder> good morning, I'm installing ubuntu 16.04 LTS on my lenovo desktop. I'm currently stuck on the partitioning table.I have 16004 MG of free space and i can't seem to get it right. i divide the space up as follows: 7967mb ext4,primary,beg, mount / : 34 efi,logical,beg : 8002 swap,logical,beg. And it keeps switching between errors of: root system not defined, swap area failed, or efi boot needs to be defined (that was before I added <tahder> it. Any help would be much appreciated <joelio> paranoidabhi: yea, /etc/modprobe.d/blacklist is where you can put it 'blacklist r8169' and give that a try <joelio> you won't get any nic - but at least if it goes quick, then you know why it's slwo booting <joelio> and bet a usb nic for cheap if you need or something <saitoh183_> joelio:will i need a new db <paranoidabhi> joelio, is it blacklist.conf in 16.04? <joelio> saitoh183_: well if your SQL doesn't have a CREATE DB func at the top <joelio> yes, also, check the user has perms to create the db.. but just use the same credentials as what you were useing <joelio> that should be fine <joelio> paranoidabhi: I think so, yea, look inside it and check <joelio> paranoidabhi: tbh I don't that that will be it <joelio> as that dmesg spam looks like it runs at all times <joelio> but not my machine :) <paranoidabhi> joelio, the spam occurs on disconnecting the ethernet cable not always. <dutchie> Hi, I'm having some trouble with a custom PAM module I've put into /lib/x86_64-linux-gnu/security (where all the other PAM modules are). auth.log seems to indicate that it's looking in /lib/security, but that doesn't even exist. Do I need to do more than just dropping my .so in place? <dutchie> (this is on 14.04) <gnumonk> Hi <gnumonk> what is the "cgroup 7.7G 0 7.7G 0% /sys/fs/cgroup" in df -kh output <nacc> gnumonk: cgroup filesystem https://www.kernel.org/doc/Documentation/cgroup-v1/cgroups.txt <nacc> gnumonk: it's a virtual file system (like /proc and /sys) <anddam> is there a way to have usb devices belonging to a specific group the same way block devices belong to group disk? <c0ax> Hello there, can someone help me? <gnumonk> nacc: ok its had actully reserved 7.7 GB disk space? <nacc> gnumonk: no <sahil> hello <DJones> c0ax: Ask your question in the channel, until you do that, people won't know if they can help <ducasse> anddam: i guess you could set up a udev rule <nacc> gnumonk: i'm guessing it will look similar to the other tmpfs filesystems in size <gnumonk> nacc: So I have confusion here, lsblk shows hard disk size let say "100GB" but df -kh shows 84G, where 7 GB for tmpfs and 7GB for cgroups. <sahil> i am running ubuntu gnome based on ubuntu 13.10.i would like to know to to upgrade it to latest version. thanks <c0ax> I have problem with my ubuntu 16.04. Ive installed openssh clinet/server and netstat -tulpn says that 22 is running ive added rule to the iptables also ufw allow 22. But im not able to connect to it from other computer on the SAME network. I can ping it, but cant connect <gnumonk> sahil: upgrade to 14.04 first
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1146, 5189, 13, 533, 342, 5233, 4884, 342, 337, 14, 81, 4108, 6771, 281, 830, 31023, 14337, 48427, 84, 15, 496, 253, 1083, 273, 11901, 18054, 1401, 1010, 8200, 253, 4884, 1885, 369, 3413, 281, 320, 1401, 2405, 424, 313, 805, 6, 5043, 1283, 6, 347, 253, 7043, 13, 1401, 1237, 8200, 544, 1470, 15, 577, 1084, 39, 21, 910, 709, 14, 881, 568, 926, 9471, 1223, 546, 311, 38739, 1401, 1012, 424, 285, 1401, 1166, 424, 3534, 1401, 1717, 424, 285, 1401, 2405, 424, 313, 24, 6, 285, 608, 6, 11026, 582, 2975, 13, 2220, 4884, 342, 253, 40299, 3325, 2689, 587, 15, 187, 187, 3138, 49, 6147, 14337, 1885, 1401, 2405, 424, 285, 7043, 1401, 1237, 424, 2797, 432, 4884, 273, 11901, 18054, 1401, 1010, 424, 342, 475, 79, 4842, 21601, 1190, 6771, 5774, 4678, 300, 6339, 64, 43, 64, 43129, 64, 29845, 14, 1047, 14, 1423, 1717, 14, 72, 5523, 4253, 39, 21, 94, 187, 187, 1231, 1735, 6949, 253, 29605, 273, 327, 348, 11421, 5094, 23, 5737, 285, 41222, 1401, 883, 35496, 1012, 424 ]	stein_J_Org_Chem-14-2229-g008){#C1} A mechanism that leads to the formation of diaminated pyrrole adduct 7 starts with amine-induced formation of a 1,4-dialdehyde, which then undergoes Paal--Knorr pyrrole formation to give an azafulvinium intermediate ([Scheme 2](#C2){ref-type="fig"}). This intermediate could then undergo trapping with an additional mole of amine nucleophile to give 7 as a mixture of diastereomers. ![Proposed mechanism for formation of onchidal diaminated adducts.](Beilstein_J_Org_Chem-14-2229-g009){#C2} In an effort to reduce the complexity of the NMR spectra observed for the diastereomeric onchidal--pyrrole adducts, a range of simpler achiral n-pentyl 11--14 and cyclohexylmethyl 15--18 side-chained model compounds, as either the dialdehyde or masked dialdehyde variants, were prepared ([Fig. 2](#F2){ref-type="fig"}). ![Target onchidal model compounds 11--18.](Beilstein_J_Org_Chem-14-2229-g003){#F2} Horner--Wadsworth--Emmons (H.W.E.) reaction of n-hexanal with phosphonoester 19 \[[@R15]\] afforded an E/Z mixture of olefinic diesters, purification of which by silica gel column chromatography afforded a fraction of the desired E diester 20 (60%), a second fraction comprised of a 5:1 E/Z mixture and a third fraction of Z diester 21 (10%, [Scheme 3](#C3){ref-type="fig"}). The reduction of diesters 20 (E) and 21 (Z) with LiAlH~4~ afforded diols 22 and 23 in 63% and 67% yield, respectively. Subsequent oxidation of 22 with DMP afforded dialdehyde 11 in 31% yield. Correspondingly, the reaction of diol 23 with DMP afforded a mixture of dialdehyde 11 with dialdehyde 12 (1:1). Attempts at chromatographic separation of these two isomers resulted in degradation of 12. Final conversion of 11 to enol acetate 13 was achieved by overnight reaction with pyridine and acetic anhydride. Purification by silica gel column chromatography afforded the desired E,E enol acetate 13 in 17% yield. A lack of purified dialdehyde 12 prevented any attempt at the preparation of enolacetate 14. ![Synthesis of n-pentyl dialdehydes 11 and 12 and enol acetate 13. Reagents and conditions: a) n-hexanal (0.8 equiv), LiOH·H~2~O (1.2 equiv), THF, 4 h, 60% (20), 10% (21); b) LiAlH~4~ (2.5 equiv), Et~2~O, 0 °C, 1 h, 63% (22), 67% (23); c) DMP (2.5 equiv), CH~2~Cl~2~, 4 h, 31% (11); d) Ac~2~O (2 equiv), pyridine (4 equiv), overnight, 17% (13).](Beilstein_J_Org_Chem-14-2229-g010){#C3} Having developed a successful synthetic route to n-pentyl side-chain dialdehyde 11 and enol acetate 13, the synthesis of analogues 15--18 with a side-chain more comparable to onchidal (6) were attempted. H.W.E reaction of 2-cyclohexylacetaldehyde (24) \[[@R16]\] with phosphonoester 19 afforded a fraction of the desired E diester 25 in 15% yield, a fraction of Z diester 26 in 1.5% yield and another fraction of a mixture of the two (5:1) ([Scheme 4](#C4){ref-type="fig"}). The reaction of diesters 25 and 26 with LiAlH~4~ afforded the corresponding diols 27 and 28 in 61% and 71% yield, respectively, which upon oxidation (DMP) afforded dialdehydes 15 and 16 in 49% and 73% yield, respectively. The reaction of dialdehyde 15 with Ac~2~O and pyridine afforded enol acetate 17 in 43% yield after purification. Interestingly, the reaction of dialdehyde 16 with Ac~2~O/pyridine only afforded decomposition products, failing to give 18. ![Synthesis of cyclohexylmethyl dialdehydes 15 and 16 and enol acetate 17. Reagents and conditions: a) phosphonate 19 (1.3 equiv), LiOH·H~2~O (1.5 equiv), THF, 4 h, 15% (25), 1.5% (26); b) LiAlH~4~ (2.5 equiv), Et~2~O, 0 °C, 1 h, 61% (27), 71% (28); c) DMP (2.5 equiv), CH~2~Cl~2~, 4 h, 49% (15), 73% (16); d) Ac~2~O (2 equiv), pyridine (4 equiv), overnight, 43% (17).](Beilstein_J_Org_Chem-14-2229-g011){#C4} The electrophilic reactivity of model dialdehydes 11 and 15 and enol acetates 13 and 17 towards 1-pentanethiol and 1-pentylamine were then studied. As found for onchidal, no reaction (NMR tube) between 11/13/15/17 and 1-pentanethiol was detected, even after one week of incubation. In direct contrast, all four model compounds reacted rapidly with 1-pentylamine, forming pyrrole adducts. The reaction of dialdehyde 11 with 1-pentylamine afforded pyrrole adduct 29 almost instantaneously as determined by ^1^H NMR. Purification of the crude reaction product gave 29 as the free base (15% yield) and as the salt, 30 (also 15% yield, [Fig. 3](#F3){ref-type="fig"}). Spectroscopic and spectrometric analysis of 29 confirmed the formation of a diamine adduct, with detection of a protonated molecular ion in the (+)-ESI mass spectrum at m/z 307.3097 (C~20~H~39~N~2~ requires 307.3108) and NMR signals appropriate for a 3-substituted N-alkylpyrrole \[δ~H~ 6.57 dd, J = 2.3, 2.3 Hz, H-4\"; 6.54 br s, H-1\"; 6.04 dd, J = 2.3, 2.3 Hz, H-3\"; δ~C~ 120.8 (C-2\"), 120.3 (C-4\"), 118.4 (C-1\"), 106.2 (C-3\")\]. ![Pyrrole product 29 and salt 30 obtained from the reaction of dialdehyde 11 with n-pentylamine.](Beilstein_J_Org_Chem-14-2229-g004){#F3} As proposed for the onchidal--diamine adduct, the formation of 29 is presumably a consequence of dialdehyde 11 undergoing Paal--Knorr pyrrole formation to form an azafulvenium intermediate which is subsequently quenched with another mole of amine nucleophile to form the observed product ([Scheme 5](#C5){ref-type="fig"}). ![Reaction of dialdehyde 11 with excess 1-pentylamine to form 29. Reagents and conditions: (a) 1-pentylamine (excess), CDCl~3~, overnight.](Beilstein_J_Org_Chem-14-2229-g012){#C5} Similar reactivity profiles were observed for each of cyclohexylmethyl dialdehyde 15, and enol acetates 13 and 17, with no reactivity towards 1-pentanethiol being detected, but with rapid reaction with 1-pentyamine to form pyrrole adducts. In the case of dialdehyde 15, the reaction product was determined to be 31 (12% plus 18% as the salt, 32, [Fig. 4](#F4){ref-type="fig"}), while enol esters 13 and 17 gave 29 and 31 (7% and 5% yields), respectively, upon reaction with the amine nucleophile. ![Pyrrole product 31 and salt 32 obtained from reaction of dialdehyde 15 with n-pentylamine.](Beilstein_J_Org_Chem-14-2229-g005){#F4} We next investigated the reactivity of onchidal (6) and analogues 11--13
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13, 849, 3253, 281, 513, 342, 849, 359, 10196, 310, 16202, 275, 776, 3882, 13, 285, 849, 359, 403, 1335, 2403, 747, 32912, 1046, 1388, 15, 733, 816, 31597, 479, 283, 395, 1335, 1057, 15, 733, 310, 10412, 281, 479, 13, 533, 671, 387, 253, 1072, 673, 3264, 13, 326, 359, 476, 1024, 12921, 3882, 15, 313, 1147, 3133, 751, 352, 651, 320, 1896, 672, 309, 1158, 896, 281, 253, 1039, 3882, 310, 10357, 517, 285, 37221, 326, 387, 690, 1127, 1309, 326, 673, 359, 651, 320, 2104, 281, 564, 275, 627, 285, 12921, 253, 3882, 15, 309, 457, 78, 417, 2119, 326, 457, 84, 672, 436, 3320, 14835, 651, 2686, 5108, 13, 533, 326, 651, 320, 4722, 281, 871, 2698, 309, 369, 12371, 672, 436, 673, 651, 1705, 13 ]	srep30637-f5){#f5} ![Cell cycle phase distribution after exposure to radial extracorporeal shock waves.\ Data show relative numbers (mean ± SEM) of HFFF2 (A) and JEG-3 (B) cells in the G0/G1, S and G2/M phases 24 h after exposure to sham-rESWs (open bars) or to 500 rESWs (closed bars). \*p \< 0.05.](srep30637-f6){#f6} ###### Examples of studies investigating the effects of focused (fESWs) and radial (rESWs) extracorporeal shock waves on musculoskeletal disorders including tendons in clinical settings, animal models, and fibroblast cultures. fESWs rESWs ------------------------ ----------------------------------------------------------------------------- ----------------------------------- --- Clinical setting Reviewed in Schmitz et al.[@b4] Reviewed in Schmitz et al.[@b4] Animal models Reviewed in Visco et al.[@b38] --- Fibroblast culture Viability Kaulesar Johannes et al.[@b22]Berta et al.[@b25]Hausdorf et al.[@b26] --- Growth potential Kaulesar Johannes et al.[@b22]Berta et al.[@b25] --- Gene expression Berta et al.[@b25] (TFG-β1,collagen type I and III) --- Growth factor release Hausdorf et al.[@b26] (FGF-2, TGF-β1) --- Cell cycle changes --- --- ###### Details of the statistical analysis of the quantitative analysis of cell viability after exposure to radial extracorporeal shock waves. Cell type P (ANOVA) P (Bonferroni post hoc tests for pairwise comparisons) ---------------------------- ----------- ---------------------------------------------------------- -------- -------- -------- ---- -------- -------- ---- -------- ---- Trypan blue negative cells HFFF2 \\\* ns \\\* \\\* \\\* ns \\ \\\* ns \* ns JEG-3 \\\* ns ns \\\* \\\* ns \* \\\* \* \\\* \* Trypan blue positive cells HFFF2 \\\* ns \\ \\\* \\\* ns \\\* \\\* ns \\ ns JEG-3 \\\* ns ns \\\* \\\* ns \\ \\\* ns \\ ns Primary effects of rESWs on cell viability were analyzed using one-way ANOVA followed by Bonferroni post hoc tests for pairwise comparisons. \p \< 0.05; \\p \< 0.01; \\\p \< 0.001; ns, not significant. ###### Details of the statistical analysis of the quantitative analysis of cell count. Cell type P (ANOVA) P (Bonferroni post hoc tests for pairwise comparisons) ----------- ----------- ---------------------------------------------------------- -------- -------- ---- ---- -------- -------- HFFF2 \\\* \\\* \\\* 48 hrs ns \* \\\* \\\* 72 hrs \* \\\* \\\* \\\* JEG-3 \\\* \\\* \\\* 48 hrs ns ns ns \\\* 72 hrs ns ns ns \\\* Cell counts were analyzed by two-way ANOVA followed by Bonferoni post hoc tests for pairwise comparisons. The table shows results of comparisons between mean numbers of cells exposed to sham-rESWs and of cells exposed to rESWs at 48 and 72 hours after exposure. \p \< 0.05; \\\p \< 0.001; ns, not significant. ###### Details of the statistical analysis of the quantitative analysis of cell count influenced by conditioned medium (CM). Cell type P (ANOVA) P (Bonferroni post hoc tests for pairwise comparisons) ----------- ----------- ---------------------------------------------------------- -------- -------- ---- ---- -------- HFFF2 \\\* \\\* \\\* 48 hrs ns \* \\\* 72 hrs \* \\\* \\\* Cell counts were analyzed by two-way ANOVA followed by Bonferoni post hoc tests for pairwise comparisons. The table shows results of comparisons between mean numbers of cells exposed to sham-rESWs (cultured either in fresh culture medium or conditioned medium) and of cells exposed to 500 rESWs (cultured either in fresh culture medium or conditioned medium) at 48 and 72 hours after exposure. \p \< 0.05; \\\p \< 0.001; ns, not significant. Amending Kenya draft tricky, say Ministers March 26, 2010 12:00 am Shares By ANTHONY KAGIRI, NAIROBI, Kenya, Mar 26 – The reality of the daunting task of passing amendments to the Proposed Constitution started sinking on Friday with two Cabinet Ministers admitting that there are slim chances of success. Immigration Minister Otieno Kajwang said it was unlikely that the numerous amendments being fronted by Members of Parliament would pass the test of 145 members’ support to sail through. Mr Kajwang said with the battle lines between political parties already drawn, it was almost certain none of the amendments would pass. “Sixty five percent is close to unanimous and one will have to bring a very good amendment which almost all of us agree with,” said Mr Kajwang. The Minister however said there was a shared feeling that the Proposed Constitution is better than the current law, and would sail through the House with or without amendments “Our party (Orange Democratic Movement) had planned to push for the introduction of regions but we have noticed it is going to be a bit difficult to get agreement,” he added. Speaking elsewhere Justice and Constitutional Affairs Minister Mutula Kilonzo concurred with Mr Kajwang but said non-political issues could attract the numbers. He singled out the clause on abortion and the creation of the Parliamentary Fund as some which had support across the political divide. Mr Kilonzo however regretted that the failure by MPs to agree in their retreat early in the week had made the situation more difficult. “I would propose to those seeking amendments to seek support across the board and put the amendments that have considerable consensus in a package then we can vote for them in the House easily,” he told Capital News on phone from his Mbooni constituency. However as Members of Parliament rush to submit amendment proposals, a section were vowing to frustrate any amendments to the Proposed Constitution, saying their colleagues are out to mutilate the draft. Imenti Central MP Gitobu Imanyara on Friday claimed to have mobilised 80 MPs to prevent what he called entrenchment of the views of the status quo. “Those of us who are determined to bring a new Constitution have agreed to block all attempts for amendments,” he told Capital News. “We should not be worried by the sideshows and the narrow considerations that is behind a lot of these new proposed amendments.” MPs are scheduled to debate and vote on the amendments next Wednesday. By Thursday the office of the Clerk had 19 amendments surrounding abortion, Kadhis courts and the tenures of the Attorney General, Chief Justice and the Auditor and Controller General. There were unconfirmed reports that by Friday midday close to two hundred requests for amendments had reached the legal team. The team will however merge most of the proposals since they touch on similar matters. Should any of the amendments pass the document will be sent back to the Committee of Experts to incorporate them. Should the proposed document pass without amendments it will be forwaded to the Attorney General for publication in readiness for the referendum.Monday, August 8, 2016 First of all, just because I thought this was great, I want to share how my dad picked up this article, read it, and then kept asking again and again whether I had read it yet. I guess I know where I get my fascination with biology from! Second of all, CRISPR sounds like something to do with keeping salad greens fresh. It is obviously an acronym for something important and relating to the process, but still. Ok, now down to article. The genetics unit was my favorite; I loved how everything went together, how everything to do with how we operate is encoded in our DNA, and how we are still making new discoveries every day. It just amazed me--and still does. It is crazy to me, but also at the same time expected, that we can now edit DNA. (It seems like it would be possible when I think back to the way DNA is unwound and replicated that at some point during that time we would be able to go in there and edit the DNA. I’m not sure that’s when this gene editing would actually happen, but that would be interesting to know.) I was wondering when this time would come,
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731, 15, 3856, 13, 2305, 15, 7335, 357, 40581, 1052, 12511, 13, 594, 253, 4284, 3722, 310, 2686, 6685, 16592, 15, 35794, 625, 29584, 588, 1361, 779, 247, 2257, 15, 1422, 476, 25464 ]	2 is built: subset1 <- which(merge_stats$Time >= 6 & merge_stats$Time <= 10) p1 <- ggplot(merge_stats[subset1, ], aes(y = weight, x = as.numeric(Time))) + geom_jitter(color="grey", width=0.1)+ geom_errorbar(aes(ymin=SDbelow[subset1], ymax=SDabove[subset1]), width=0.1, size=1)+ stat_summary( geom = "point", fun.y = "mean", col = "blue", size = 2, shape = 19, fill = "blue") inset <- ggplotGrob(p1) ggplot(merge_stats, aes(y = weight, x = as.numeric(Time))) + geom_jitter(color="grey", width=0.1)+ geom_errorbar(aes(ymin=SDbelow, ymax=SDabove), width=0.1, size=1)+ stat_summary( geom = "point", fun.y = "mean", col = "blue", size = 2, shape = 19, fill = "blue") vp <- grid::viewport(width = 0.4, height = 0.4, x = 0.3, y = 0.7) print(p1, vp = vp) import { next } from '@ember/runloop'; import { describe, beforeEach, it } from 'mocha'; import { expect } from 'chai'; export default function(options) { let syncExternalChanges = options.syncExternalChanges \|\| function() {}; let store; // eslint-disable-next-line mocha/no-top-level-hooks beforeEach(function() { store = options.store(); }); // eslint-disable-next-line mocha/no-top-level-hooks afterEach(function() { store.clear(); }); describe('#persist', function() { it('persists an object', async function() { await store.persist({ key: 'value' }); let restoredContent = await store.restore(); expect(restoredContent).to.eql({ key: 'value' }); }); it('overrides existing data', async function() { await store.persist({ key1: 'value1' }); await store.persist({ key2: 'value2' }); let restoredContent = await store.restore(); expect(restoredContent).to.eql({ key2: 'value2' }); }); it('does not trigger the "sessionDataUpdated" event', function(done) { let triggered = false; store.one('sessionDataUpdated', () => (triggered = true)); store.persist({ key: 'other value' }); syncExternalChanges(); next(() => { expect(triggered).to.be.false; done(); }); }); }); describe('#restore', function() { describe('when the store is empty', function() { it('returns an empty object', async function() { await store.clear(); let restoredContent = await store.restore(); expect(restoredContent).to.eql({}); }); }); describe('when the store has data', function() { beforeEach(function() { return store.persist({ key1: 'value1', key2: 'value2' }); }); it('returns all data in the store', async function() { let restoredContent = await store.restore(); expect(restoredContent).to.eql({ key1: 'value1', key2: 'value2' }); }); it('returns a copy of the stored data', async function() { let data = await store.restore(); data.key1 = 'another value!'; let restoredContent = await store.restore(); expect(restoredContent).to.eql({ key1: 'value1', key2: 'value2' }); }); }); }); describe('#clear', function() { it('empties the store', async function() { await store.persist({ key1: 'value1', key2: 'value2' }); await store.clear(); let restoredContent = await store.restore(); expect(restoredContent).to.eql({}); }); }); } Phospholipase A2 and its molecular mechanism after spinal cord injury. Phospholipases A(2) (PLA(2)s) are a diverse family of lipolytic enzymes which hydrolyze the acyl bond at the sn-2 position of glycerophospholipids to produce free fatty acids and lysophospholipids. These products are precursors of bioactive eicosanoids and platelet-activating factor which have been implicated in pathological states of numerous acute and chronic neurological disorders. To date, more than 27 isoforms of PLA(2) have been found in the mammalian system which can be classified into four major categories: secretory PLA(2), cytosolic PLA(2), Ca(2+)-independent PLA(2), and platelet-activating factor acetylhydrolases. Multiple isoforms of PLA(2) are found in the mammalian spinal cord. Under physiological conditions, PLA(2)s are involved in diverse cellular responses, including phospholipid digestion and metabolism, host defense, and signal transduction. However, under pathological situations, increased PLA(2) activity, excessive production of free fatty acids and their metabolites may lead to the loss of membrane integrity, inflammation, oxidative stress, and subsequent neuronal injury. There is emerging evidence that PLA(2) plays a key role in the secondary injury process after traumatic spinal cord injury. This review outlines the current knowledge of the PLA(2) in the spinal cord with an emphasis being placed on the possible roles of PLA(2) in mediating the secondary SCI.Q: Find descendants of a specific node with Xpath Say I have an xml document and want to get the "NodeID" and "Description" element out of each Node, without necessarily knowing whether they're a sub-element of some child, or just a child. <Stuff> <data> <Nodes> <NodeID>1</NodeID> <Name>thingA</Name> <MoreInfo> <Description>Scooter</Description> </MoreInfo> </Nodes> <Nodes> <NodeID>2</NodeID> <Name>thingB</Name> <MoreInfo> <Description>Bike</Description> </MoreInfo> </Nodes> </data> </Stuff> So I'd ideally end up with: 1, Scooter; 2, Bike. NodeList nodes = (NodeList) xpath.evaluate("Nodes", resultXml, XPathConstants.NODESET); for (int i = 0; i < nodes.getLength(); i++) { Node node = nodes.item(i); logger.info("Evaluating: " + node.toString()); String nodeID = xpath.evaluate("//NodeID", node); String description = xpath.evaluate("//DescriptionID", node); System.out.println("Found: " + nodeID + ", " + description); } The output is as follows: Evaluating: <NodeID>1</NodeID><Name>thingA</Name><MoreInfo><Description>Scooter</Description></MoreInfo> Found: 1, Scooter Evaluating: <NodeID>2</NodeID><Name>thingB</Name><MoreInfo><Description>Bike</Description></MoreInfo> Found: 1, Scooter The node is correct, but it keeps "finding" things as if it were looking from the beginning of the xml document. How do I search just for decendents of the node in question? I would think that the node being the source of the evaluation would do the trick... A: //NodeID and //Description are absolute paths which will start searching from the root of the document that contains the context node. The expressions in this case will match all nodes named NodeID (respectively Description) in the whole document, and when you evaluate such an expression as a string this will give you the string value of the first matching node in document order. To look just within the context node itself you need to use relative paths by adding a leading dot, for example .//NodeID. A bed of nails can actually be comfortable, if there are enough nails. A person's weight is divided by the number of nails under them. Here, Mr. Slab weighs 200 pounds, so the default bed is actually extremely painful. Adding more nails will help him a lot. You can replicate
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10362, 275, 3718, 273, 7167, 40, 15, 187, 187, 2214, 247, 5322, 896, 737, 10117, 327, 253, 48423, 13465, 15561, 13, 2451, 562, 436, 5313, 432, 7216, 434, 5625, 31566, 33602, 15, 6930, 187, 475, 8283, 4332, 14, 9638, 1284, 518, 26407, 25780, 10589, 15, 187, 475, 187, 475, 21737, 762, 253, 14325, 4637, 13, 11099, 374, 15, 17, 313, 783, 346, 17736, 3287, 187, 475, 368, 778, 417, 897, 436, 1873, 3707, 275, 10276, 342, 253, 4637, 15, 187 ]	disclosed in Japanese Patent Publication No. 6457/89 is effective for preventing the development of a polarizing toner at an image edge portion, while it appears of substantially no effect on the aforementioned problem. Furthermore, toners having a variety of structures and processes for preparing the toners have been proposed for eliminating the aforementioned problems and improving the functions of toners. For example, there are proposed a toner in which conductive particles are fixed on the surface of a toner in a hot air stream and insulating particles are further fixed thereon in a hot air stream to form a structure having both a conductive layer and an insulating layer on the surface of the toner particles (Japanese Patent Laid-Open Publication No. 257763/88), toners having a multi-layer structure such as microcapsule toners prepared by the polymerization method and used for low-energy fixing (U.S. Pat. 3,080,250, Japanese Patent Publication Nos. 31066/84 and 36934/89), toners of which an external surface is coated with a charge control resin film layer for controlling charge with the use of the high speed impact method in the dry process (Japanese Patent Laid-Open Publication No. 62666/88) or a toner of which the surface has been treated with a resinous finely divided powder in order to obtain anti-blocking properties (Japanese Patent Laid-Open Publication No. 105261/89). These conventional toners, however, still have some points which needs to be improved.FEATURED SPONSORS The Am Law Litigation Daily: Feb. 10, 2009 Posted by Andrew Longstreth IP Obama Poster Case Is Rematch for Ex-Bingham Partner Falzone and O'Melveny's Cendali When an artist creates an iconic poster using a photograph taken by someone else, who owns the work? Shepard Fairey, the artist and guerilla marketer who designed the ubiquitous, two-toned "Hope" poster of President Barack Obama, has an answer: the artist. On Monday, Fairey sued The Associated Press in Manhattan federal district court, seeking a declaratory judgment that his use of an Obama photograph taken by AP photojournalist Mannie Garcia falls within fair use boundaries. On a side note, Fairey was arrested Friday in Boston on his way to an opening party for a retrospective of his work. Not for copyright violations, though: He had two outstanding warrants for cases involving illicit posting of street art featuring Andre the Giant and the word "obey." Jeffrey Wiesner of Boston's Stern Shapiro Weissberg & Garin is representing Fairey in the criminal case. No seismic shocks will come from the documents. The best details, including the names of the parties, have been redacted, reports Reisinger. But White & Case partner J. Mark Gidley, who negotiated the FOIA settlement, told Reisinger that antitrust lawyers can glean good information from the agreements, which he said "show deviations from the model amnesty letter in terms of privilege waivers and coverage of subsidiaries." Other antitrust attorneys, however, wonder if the White & Case FOIA suit may backfire on practitioners. Jones Day partner John Majoras told Reisinger he worries that the release of the agreements may end up stifling prosecutorial discretion. "If DOJ now says, 'We're just using the model letter,' then that's unfortunate for a company," he said. Appellate / Product Liability / Mass Torts Should Chief Justice (and Pfizer Shareholder) John Roberts Recuse Himself in Wyeth Preemption Case? While we anxiously wait for a decision from the Supreme Court in the biggest business case of the term, Wyeth v. Levine, Tony Mauro of Legal Times poses an interesting question: Should Chief Justice John Roberts, Jr., recuse himself from deliberations? After all, Roberts owns stock in Pfizer, which recently agreed to buy Wyeth for $68 billion. Roberts has stepped aside in previous Pfizer cases, according to Mauro. But the Court heard arguments in Levine back in November, and the chief justice may have made up his mind before the Pfizer acquisition was announced. Moreover, Pfizer's Wyeth deal won't be completed until July 31 at the earliest, according to a recent letter submitted by Wyeth's lawyer, Seth Waxman of Wilmer Cutler Pickering Hale and Dorr. In that letter (available here, via the Drug and Device Law blog), Waxman said that the proposed merger did not require Wyeth to update the corporate disclosure statement it made to the Court last year. Mauro speculates that Roberts could shed his Pfizer stock to avoid the recusal issue. Or he could stay on the case. "Either way," Mauro writes, "it will be an interesting test of whether news of an acquisition--even before it occurs--will affect justices' recusal practices." Securities UBS and the Foreign Plaintiffs: An 'F-Cubed' Class Action Story The Litigation Daily admits to an unaccountable (and possibly unhealthy) fascination with the F-cubed issue in securities class actions. So we're closely following the UBS AG case in Manhattan federal district court, in which investors, in the wake of the bank's $48.6 billion write-down on its mortgage-backed securities, claim that UBS issued false and misleading statements about its risk management controls, its exposure to risky assets, and the value of the securities on its books. Last week the plaintiffs filed a response to UBS's motion to dismiss claims brought by foreign plaintiffs who purchased UBS shares on foreign exchanges. In their response, lawyers for the plaintiffs argue that the foreign plaintiffs should be included in the proposed class because, among other things, UBS's alleged activity in the U.S. "directly caused foreign plaintiffs' losses." They also tried to distinguish their case from NAB, arguing that the UBS foreign plaintiffs, unlike their NAB counterparts, did not rely exclusively "on the falsity of financial statements prepared in [a foreign country] by a foreign issuer," they wrote. Securities Kasowitz Benson Files Auction-Rate Securities Suit for American Eagle Against Citigroup Long live the auction-rate securities scandal! Just as state and federal regulators appear to be wrapping up their investigations into banks that promoted the securities as safe and liquid investments even as the market for them had dried up, private litigation continues. The latest entrant is American Eagle Outfitters. The apparel company filed a suit in Pittsburgh federal district court last week against Citigroup, alleging that the bank induced it to buy auction-rate securities when Citigroup knew the market for them was collapsing. American Eagle's complaint cites internal Citigroup e-mails and memos showing that as the market for auction-rate securities imploded in December 2007, Citigroup sought to "offload" them to its customers, including American Eagle. According to the suit, Citigroup allegedly made internal plans to stop supporting the auction-rate securities market at the same time it was promoting the securities to its customers. American Eagle is using Kasowitz, Benson, Torres & Friedman in the ARS suit, proving once again that this is a good time to be a litigation boutique that's free to sue big banks. Appellate / Sports Watch It Live: Barry Ostrager and Maureen Mahoney to Argue America's Cup Case As Litigation Daily readers know, another of our unaccountable passions is the litigation surrounding the 33rd America's Cup. (Click here and here for our previous coverage.) On Tuesday at 2 p.m., we'll be able to watch it unfold live. The New York Court of Appeals (the state's highest court) is planning to Webcast oral arguments in the case of Golden Gate Yacht Club v. Société Nautique De Genève, which will determine the challenger of record for the next America's Cup, scheduled for 2010. Given the legal talent involved, it should be worth watching. Appellate ace Maureen Mahoney of Latham & Watkins will be arguing for the Golden Gate Yacht Club, whose BMW Oracle Racing team claims that it is the rightful challenger for the Cup. Barry Ostrager, head of the litigation department at Simpson Thacher & Bartlett, will be arguing for the current holder of the Cup, Société Nautique de Genève, whose Alinghi syndicate chose Club Nautico Espanol de Vela as the challenger of record for the 2010 race. David Rivkin of Debevoise & Plimpton, who represents Club Nautico Espanol, will also be allotted time during oral arguments at the court of appeals. Right now, Ostrager and Rivkin have the upper hand: In July the New York State Supreme Court issued a 3-to-2 ruling in favor of SNG. For a nice backgrounder on the fiercely fought litigation, check out this piece from Monday's International Herald Tribune./** * Copyright 2011-2019 Asakusa Framework Team. * * Licensed under the Apache License, Version 2.0 (the "License"); * you may not use this file except in compliance with the License.
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2905, 2298, 7299, 1005, 1016, 807, 1008, 2041, 15 ]	garden. Despite my protective clothing, eye mask and rubber gloves I was blantanly not rocking it as Superwoman. Luckily it was not the poo drain just the kitchen one otherwise there would have been more than retching going on. I live in an old house which to be fair is starting to cheese me off a bit now. I don’t even have central heating as there is no gas supply where we live. Yes really, 2017 and no gas supply has made it to some of the villages in this country yet. My drains are prehistoric to say the least and are a crude concrete design which means that most things stick to it on the way down. The poo one is always getting blocked as you can’t make a very good corner out of concrete and anything remotely larger than wee gets stuck on the sharp edge. I do draw the line at clearing that one though, which we usually have to do at least once a year. It is amazing how much they stink, after all the kitchen one is just waste from the washing machine and the sink isn’t it? It was grimy and sludgy and grey and smelly. Urgh! However, I cleaned it and picked out all the sludge and hosed it down and now it’s as good as new, well for a few months anyway. While I was feeling all manly I thought I would chop some logs for the fire. I have an open fire and although the ‘wood guy’ does bring me small stuff there are usually odd ones that could do with chopping in half. Yep, I definitely need a man for that. I gave up quite quickly after nearly losing my toes and instead decide to come indoors and build up my biceps first with a couple of baked bean tins. That lasted about one and half minutes. I have never been a gym bunny and it shows. I have wobbly bits and my arms are about as strong as spaghetti. Is it too late for me to toughen up? I am going to need to think seriously about this as it does not look there will be a man in my life anytime soon and as much as it pains me to admit it, the only thing I am likely to be able to chop is a carrot. Otherwise it has been a quiet weekend, with just me and the kids and I’m a celebrity. Well, I’m almost a celebrity more like but we still love it, if only for Ant and Dec. That is two weekends in a row with no dates and to be fair it has been quite nice. That’s not to say that I haven’t had any action, so to speak. One of the greatest messages I have received to date (apart from Christians offer of dirty sex, which I still dream about, sad as that may be), is below; “Hi, I’m 42, have a 2 bed flat live alone oh apart from a lodger whose rarely in , 3 kids (one grown up), work as a groundwork foreman, a little wild but big heart, impatient, passionate, all or nothing sort of man. Now this is exciting meeting someone you haven’t met before, John ???? look me up on Facebook and my address is 48 ???? and I don’t want to know about you as the excitement is heightened, I am waiting hard for you now.” Excitement, I’m bloody terrified not excited. Why would you give your full address out to a complete stranger and not just to me but probably to a dozen other woman who just happened to be online at that time. Crazy fool… and why don’t you want to know about me. You should want to know about me. You should at least want to know I am who I say I am, shouldn’t you? I know I said I wanted excitement but bloody hell. I would also like to make it to my next birthday. I declined to pop round that night or indeed ever. I don’t know what frightened me more the fact that he was naked and headless in his profile picture or the thought of his lodger who in my mind (I know It’s overactive) was like Jack the Ripper and just came back every now and then to rip out a few organs. Okay, I’m fessing up now, I’m struggling with this. I don’t know what I’m doing wrong but if they are sane they are too sane and if they are nuts they are really fucking nuts. Where do you go to find your average Joe these days. I can’t just loiter around in Waitrose on a daily basis like the papers suggest, fondling the aubergines. Who would look weird then? Two of the guys that are messaging me at the moment are married and blatantly so. They are assuming that honesty is the best policy and so are offering for ME to USE THEM and then if I meet someone who can offer something better then I can ditch them and we both move on. If not I can have NSA with them for as long as I want or they want, as long as I’m discreet. Oh what a lovely lot of humans we are. The others are the thirty somethings who want to have a casual regular sex thing (whatever that may be) or so they say… they talk a good talk at least. They don’t really seem to deliver on it though. I, on the other hand am really fed up with just talking about it. I love a bit of banter. Who doesn’t? I do also love a good bit of chat too though and a nice combination of both works for me. Remember J, he had it right, he talked a lot about all sorts of stuff, made me laugh a lot and was very flirty but not in a ‘any chance of a blow job’ kind of way, but in a sexual, teasing way. This it seems is rare. Luckily (tongue in cheek) there are two, yes just two, out of the 44,468 people currently online that can seem to be able to hold a conversation about something other than what is going on in their trousers and one of them has just asked me on a date. Quick as that. He messaged this morning, said Hi. Simple. Now we are having lunch in Brighton on Saturday. It’s a long way off yet and so I’m not going to start worrying about what to wear as a lot can happen in the virtual world of dating in 24 hours, nevermind 5 whole days. By Saturday I could have been swept of my feet unexpectedly by someone who works around the corner from me. Unlikely, but you never know. He could also have a date every night next week and the same could happen. So although I am looking forward to date number 7 (is it?), let’s not count our chickens. Brighton is a considerable distance from me and so I do hope it is worth the trip and the extortionate parking fees to visit somewhere considered to be so cosmopolitan. I also hope that it actually happens now as I’ve broadcast it to the world. It’s always a bit embarrassing when you announce something out loud and then have to say a few days later… oh, well he changed his mind actually, grass is greener and all that…. and trying to maintain your ‘I’m not really bothered face’ is even harder.Main Navigation Joanne Holden Jo is an accomplished Quality Management professional with over 20 years’ experience across a number of manufacturing and service industries including specialist carbon fibre production, chemical manufacture, printing technology, public sector, local authorities and education. In addition to her degree in Chemistry, she holds a Diploma in Statistical Quality Control and the Advanced Diploma in Human Resource Management. Since joining Equas in 2011, Jo has helped a wide range of manufacturing, construction, business services and social care businesses to achieve certification to ISO 9001, ISO 14001, OHSAS 18001/ISO 45001 and ISO 50001. Jo’s expert grasp of the ISO principles combined with her practical approach ensures that the work she does for our clients is both effective and durable. Joanne's clients Joanne's testimonials Our Consultant Jo Holden has been exceptional from day 1. She has been supportive and encouraging, she has been open and honest and is so approachable and easy to work with. She engages efficiently and confidently at all levels and has literally been a god send for me, going into something like this with no prior experience or knowledge of ISO - I was absolutely terrified and Jo gave myself and our Board of Directors the confidence not only to go for the two standards (9001, 14001) but to add on a 3rd (18001) and transition to 2015 on the first two within 5 months of initial certification. I cannot thank her or praise her enough. I would have no hesitation to recommend your services based on our fantastic experience with Jo. The service, support and experience has been exemplary. Kerry Lambson 27/05/2016 First Rail Support An absolutely outstanding service doing exactly what you said you could do, on budget and on time. I am hugely impressed. Thank you. As part of the Amtivo Group, Equas is a management consultancy that specialises in helping organisations improve their management systems, thereby enabling them to become more efficient and achieve more of their strategic objectives.Introduction {#s1} ============ Many mothers living in developing countries continue to die from pregnancy related morbidities each year [@pone.
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dict:from_list(SortedResults), [dict:fetch(Key, KeyDict) \|\| Key <- Keys]. url_strip_password(Url) -> re:replace(Url, "(http\|https\|socks5)://([^:]+):[^@]+@(.)$", "\\1://\\2:****@\\3", [{return, list}]). encode_doc_id(#doc{id = Id}) -> encode_doc_id(Id); encode_doc_id(Id) when is_list(Id) -> encode_doc_id(?l2b(Id)); encode_doc_id(<<"_design/", Rest/binary>>) -> "_design/" ++ url_encode(Rest); encode_doc_id(<<"_local/", Rest/binary>>) -> "_local/" ++ url_encode(Rest); encode_doc_id(Id) -> url_encode(Id). normalize_ddoc_id(<<"_design/", _/binary>> = DDocId) -> DDocId; normalize_ddoc_id(DDocId) when is_binary(DDocId) -> <<"_design/", DDocId/binary>>. with_db(DbName, Fun) when is_binary(DbName) -> case couch_db:open_int(DbName, [?ADMIN_CTX]) of {ok, Db} -> try Fun(Db) after catch couch_db:close(Db) end; Else -> throw(Else) end; with_db(Db, Fun) -> case couch_db:is_db(Db) of true -> Fun(Db); false -> erlang:error({invalid_db, Db}) end. rfc1123_date() -> {{YYYY,MM,DD},{Hour,Min,Sec}} = calendar:universal_time(), DayNumber = calendar:day_of_the_week({YYYY,MM,DD}), lists:flatten( io_lib:format("~s, ~2.2.0w ~3.s ~4.4.0w ~2.2.0w:~2.2.0w:~2.2.0w GMT", [day(DayNumber),DD,month(MM),YYYY,Hour,Min,Sec])). rfc1123_date(undefined) -> undefined; rfc1123_date(UniversalTime) -> {{YYYY,MM,DD},{Hour,Min,Sec}} = UniversalTime, DayNumber = calendar:day_of_the_week({YYYY,MM,DD}), lists:flatten( io_lib:format("~s, ~2.2.0w ~3.s ~4.4.0w ~2.2.0w:~2.2.0w:~2.2.0w GMT", [day(DayNumber),DD,month(MM),YYYY,Hour,Min,Sec])). %% day day(1) -> "Mon"; day(2) -> "Tue"; day(3) -> "Wed"; day(4) -> "Thu"; day(5) -> "Fri"; day(6) -> "Sat"; day(7) -> "Sun". %% month month(1) -> "Jan"; month(2) -> "Feb"; month(3) -> "Mar"; month(4) -> "Apr"; month(5) -> "May"; month(6) -> "Jun"; month(7) -> "Jul"; month(8) -> "Aug"; month(9) -> "Sep"; month(10) -> "Oct"; month(11) -> "Nov"; month(12) -> "Dec". integer_to_boolean(1) -> true; integer_to_boolean(0) -> false. boolean_to_integer(true) -> 1; boolean_to_integer(false) -> 0. validate_positive_int(N) when is_list(N) -> try I = list_to_integer(N), validate_positive_int(I) catch error:badarg -> false end; validate_positive_int(N) when is_integer(N), N > 0 -> true; validate_positive_int(_) -> false. find_in_binary(_B, <<>>) -> not_found; find_in_binary(B, Data) -> case binary:match(Data, [B], []) of nomatch -> MatchLength = erlang:min(byte_size(B), byte_size(Data)), match_prefix_at_end(binary:part(B, {0, MatchLength}), binary:part(Data, {byte_size(Data), -MatchLength}), MatchLength, byte_size(Data) - MatchLength); {Pos, _Len} -> {exact, Pos} end. match_prefix_at_end(Prefix, Data, PrefixLength, N) -> FirstCharMatches = binary:matches(Data, [binary:part(Prefix, {0, 1})], []), match_rest_of_prefix(FirstCharMatches, Prefix, Data, PrefixLength, N). match_rest_of_prefix([], _Prefix, _Data, _PrefixLength, _N) -> not_found; match_rest_of_prefix([{Pos, _Len} \| Rest], Prefix, Data, PrefixLength, N) -> case binary:match(binary:part(Data, {PrefixLength, Pos - PrefixLength}), [binary:part(Prefix, {0, PrefixLength - Pos})], []) of nomatch -> match_rest_of_prefix(Rest, Prefix, Data, PrefixLength, N); {_Pos, _Len1} -> {partial, N + Pos} end. callback_exists(Module, Function, Arity) -> case ensure_loaded(Module) of true -> InfoList = Module:module_info(exports), lists:member({Function, Arity}, InfoList); false -> false end. validate_callback_exists(Module, Function, Arity) -> case callback_exists(Module, Function, Arity) of true -> ok; false -> CallbackStr = lists:flatten( io_lib:format("~w:~w/~w", [Module, Function, Arity])), throw({error, {undefined_callback, CallbackStr, {Module, Function, Arity}}}) end. check_md5(_NewSig, <<>>) -> ok; check_md5(Sig, Sig) -> ok; check_md5(_, _) -> throw(md5_mismatch). set_mqd_off_heap(Module) -> case config:get_boolean("off_heap_mqd", atom_to_list(Module), true) of true -> try erlang:process_flag(message_queue_data, off_heap), ok catch error:badarg -> ok end; false -> ok end. set_process_priority(Module, Level) -> case config:get_boolean("process_priority", atom_to_list(Module), false) of true -> process_flag(priority, Level), ok; false -> ok end. ensure_loaded(Module) when is_atom(Module) -> case code:ensure_loaded(Module) of {module, Module} -> true; {error, embedded} -> true; {error, _} -> false end; ensure_loaded(_Module) -> false. %% This is especially useful in gen_servers when you need to call %% a function that does a receive as it would hijack incoming messages. with_proc(M, F, A, Timeout) -> {Pid, Ref} = spawn_monitor(fun() -> exit({reply, erlang:apply(M, F, A)}) end), receive {'
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285, 13, 3021, 13, 476, 760, 1329, 253, 4430, 390, 1791, 273, 247, 3110, 275, 247, 3710, 1180, 273, 6887, 15, 5076 ]	y, z; (iii) x, −y+3/2, z−1/2. ###### Hydrogen-bond geometry (Å, °) D---H⋯A* D---H H⋯A D⋯A D---H⋯A ------------------- --------- ------- ----------- ------------- C2---H2⋯O1^i^ 0.93 2.48 3.368 (2) 159 C5---H5⋯O3^ii^ 0.93 2.62 3.539 (2) 169 C13---H13⋯O3^iii^ 0.93 2.67 3.601 (2) 174 Symmetry codes: (i) ; (ii) ; (iii) . Very interesting. New to the site, and have already noticed something quite odd. In Freestyle play order, you cannot go first if went last on the previous round. This is fair so you cannot take countries, and go first to claim the bonuses. The website LOCKS your turn until someone else takes theirs right? WRONG. The website only locks your turn until someone else BEGINS their turn! You can take your turn last, and sit there clicking refresh until someone clicks: "begin turn." At which point, if you are fast enough, you can take your turn(collect units, deploy units and reinforce etc etc) BEFORE anyone else gets to do anything. You can see that this is the reason why the rule was implemented in the first place. Granted (before I go into this any further), I will admit, I know "Freestyle" play is not an original and solid play-style, mainly used for fun. But still, in order to keep the way it was designed balanced, I propose the following: CHANGE NOTHING in the way Freestyle turn order is played, just IMPLEMENT THE RULE that is already described in the Freestyle Rules. Simply LOCK the turn of the player who took the last turn in the previous round until at least one person COMPLETELY finishes his or her turn. A player must hit: "End Reinforcements" in-order for the previous round's Last-Turn-Taker to unlock his/her turn. Is this not the essence of the rule? Making sure someone cannot take two turns in a row? The way it is now, you can. Thanks. kylegraves1 wrote:what you have described would be seq in a 2 player game where the hell did this come from the idea is shit What you have described would be classic asshattery and the instant flaming against a new member(or anyone for that matter) is against forum rules. Don't be a dick... Currently, in Freestyle turn play, you can take TWO TURNS IN A ROW... Take your turn last, and wait until someone STARTS THEIR TURN. Then you take your turn since your "begin turn" button unlocks as soon as someone else "clicks start." You haven't played very many freestyle games either... You can take two turns in a row by simply not ending your turn. If your the last person to go, just let the clock run out and then you can take your turn again. I think that's a bigger issue than what you're talking about. In heaven... Everything is fine, in heaven... Everything is fine, in heaven... Everything is fine... You got your things, and I've got mine. hecter wrote:You haven't played very many freestyle games either... You can take two turns in a row by simply not ending your turn. If your the last person to go, just let the clock run out and then you can take your turn again. I think that's a bigger issue than what you're talking about. Thanks for adding to my side of the argument, in a different way ;p That issue would be fixed along with the one I described by implementing what I proposed. PS, wtf does I haven't played many freestyle games either mean? Is everyone on these forums a dick? Imma go cry now. j35t3r.us wrote:PS, wtf does I haven't played many freestyle games either mean? Well, you just said that kyle hasn't played many freestyle games, but you're complaining about something that's a bit of a non-issue... Part of the fun of speed-freestyle is waiting for your opponent to start their turn so you can go as quickly as you can to get your armies. I really wouldn't like it if I couldn't do that anymore... Getting rid of the "Run out of time and get another turn" thing would be cool though. j35t3r.us wrote: Is everyone on these forums a dick? No, just most of us j35t3r.us wrote:Imma go cry now. Have fun! In heaven... Everything is fine, in heaven... Everything is fine, in heaven... Everything is fine... You got your things, and I've got mine. PS, wtf does I haven't played many freestyle games either mean? Is everyone on these forums a dick? Imma go cry now. Hectar wasn't being a dick, you obviously haven't played many freestyle games, as you are complaining about something that was built into the site in a specific way. There are lots more tricks to Freestyle, try playing a team game in Freestyle and see what happens! Give yourself some time around here, complete 20 or so games, then review what you have learned. Then, review the forum guidelines. If you are struggling to find that link it is on the top of every forum page. Here is an important piece of advice: One: Is my post really necessary or is it just mental diarrhea?Two: Am I trolling or feeding a troll?Three: Really? This last question should be asked at least twice but is often ignored because everyone likes to think that they are saying something ground breaking when in fact “GFYS muthafugging azzhole” and “you suck dick” are in fact not new and the only thing they will break is your reputation. Number three applies here. Are you saying something ground breaking, or is this something almost everyone else here already knows? Now, if we take your suggestion seriously, let's think for a minute: If you can't go until someone else COMPLETES there move, what is to stop them from taking too long for you to complete your own move? Now, going last in a round is basically resigning yourself to missing your next turn entirely. Finally, please use the proper form when posting in this board. Suggs and Bugs (that's this one) has a specific format. So do Cheating and Abuse, and the Create/Join Clan, and the Create/Join Tournaments, and a host of others. You have been treated fairly and generously. Please read the FAQ and Forum Guidelines. People are generally willing to help here, they just don't always use pleasantries. That is what Hectar was doing. Also, if you want to be treated seriously and nicely, do everyone else the favor and following the rules and guidelines. Thank you, and good luck at your games on CC and the Forums.-Snowman *EDIT: Was fastposted by Hectar, but what I said also still applies. Also, I don't count ANY completed Freestyle games on your profile...This invention relates to positioners in general and, more particularly, to adjustable positioners for positioning patients for medical procedures. Many medical procedures require that a patient's body or portion thereof, such as a limb, or limbs, be positioned in a particular manner. One common method for positioning a body part is to simply have an assistant hold the body part in a desired position, and change the position when requested by the physician or surgeon. As can be appreciated this method is tiring for the assistant. In addition, this method may not support the patient's body part in a sufficiently precise and rigid manner for the medical procedure. Moreover, if more than one body part needs to be positioned, several assistants have to be utilized, which is inefficient and crowds the work area around the patient. Other methods for positioning a body part utilize adjustable mechanical positioners. One common adjustable positioner is a sling that is attached to a body part and is connected by cables and pulleys to a ceiling, a free-standing support, or a boom extending from an operating table. These types of positioners are difficult to set up and take down, clumsy to adjust, and often obstruct the work area around the patient. In the field of obstetrics and gynecology, a chair or table with movable leg stirrups is typically used to adjustably position the lower portion of a patient. The stirrups, however, typically have a limited range of movement and, thus, can only support the legs of a patient in a limited number of positions. Moreover, such chairs or tables are specialized and have limited utility in other medical fields. In the field of orthopedics, a limb positioner pivotally attached to a table or chair is often used to position the arm or leg of a patient. Such a limb positioner, however, has a limited range of movement and, thus, can only support the arm or leg of a patient in a limited number of positions. Moreover
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I want to download some static websites. I have begun the process, but it seems that the maximum speed I can set to the GUI is a shade shorter than 1Mbps. My down-link is steady until 54 Mbps, so I was wondering - how do I make HTTrack download, say, at 15MBps? A: You need to put 0 for max transfer rate and add --disable-security-limits in the scan rules box + 2nd screen that William Hilsum posted. A: Unless you are downloading from an office with a hefty internet connection or you have a good fibre connection, it is unlikely (but not impossible) you are connected to the internet at 54MBs, this is infact the speed that your computer is connected to the wireless router. 1Mbps may be the limit of your connection, other than that, I use HTTrack and whilst it is very good, it is slow as it has to index the site and build up a list of files to download. If you want to check for limits, before you start the download, click on Set options... and you should be able to set any limit you want under the Limits or Flow Control tabs. A: I set the follow and am spiking at 17MiB/s on a 100Mb/s connection. Limits: Max transfer rate (B/s) = 0 B/s Max connections / second = Blank Flow Control: Number of connections = 99 Persistent connection (Kepp-Alive) = Check (enabled) enter image description here --- author: - 'A. Kalz, A. Honecker, S. Fuchs' - 'T. Pruschke' date: 'Received: May 7, 2008 / Revised version: July 18, 2008' title: Phase diagram of the Ising square lattice with competing interactions --- Introduction \[intro\] ====================== The search for exotic groundstates in two-dimensional frustrated quantum spin systems is a topic of intense research (see, e.g., Refs. [@P:misguich05; @P:richter04] for recent reviews). In this context, the antiferromagnetic $J_1$-$J_2$ spin-1/2 Heisenberg model on the square lattice has been intensively studied during the past two decades. Nevertheless, the nature of an intermediate non-magnetic phase around $J_2 \approx J_1/2$ has remained under debate until recently (see Refs. [@P:misguich05; @P:mambrini06] and references therein). Among the possible approaches to the antiferromagnetic $J_1$-$J_2$ Heisenberg model, quantum Monte-Carlo (QMC) simulations suffer from a severe sign problem in the region $J_2 \approx J_1/2$. Other approaches include perturbation theory around the Ising limit [@P:oitmaa96; @P:singh03]. A closely related model is given by hard-core bosons on the square lattice with nearest neighbour (NN) and next-nearest neighbour (NNN) hopping and repulsion terms [@P:batrouni00; @P:batrouni01; @P:wessel08; @P:chen08]. In this case, there is no sign problem such that QMC simulations are possible in principle [@P:batrouni00; @P:batrouni01; @P:wessel08; @P:chen08]. However, simple QMC algorithms suffer freezing problems in the intermediate regime at $J_2 = J_1/2$ which can be traced to a groundstate degeneracy of the Ising limit. This motivated us to perform a model study by solving the related freezing problems in Monte-Carlo (MC) simulations of the Ising model. Investigations of the two-dimensional $J_1$-$J_2$ Ising model on the square lattice have an even longer history than of the corresponding Heisenberg model, including in particular MC simulations (see, e.g., [@P:SK79; @P:landau80; @P:landaubinder80; @P:landaubinder85; @P:bloete87; @P:MKT06; @B:landaubinder]). Nevertheless, certain issues have remained controversial also in the case of the Ising model, in particular the nature of the finite-temperature phase transition for $J_2 > J_1/2$: MC simulations [@P:SK79; @P:landaubinder85; @P:MKT06] and an investigation of the Fisher zeros of the partition function [@P:monroe07] have suggested non-universal critical exponents, whereas a variational approach [@P:lopez93] and a differential operator technique [@P:AVS08] predict a first-order transition for $J_1/2 < J_2 \lesssim J_1$. In this paper we resolve this issue in favour of a weak first-order transition at least for not too large $J_2 > J_1/2$ by providing substantially improved MC results for the phase diagram. This paper is organized as follows: in section \[sec:model\] we introduce the $J_1$-$J_2$ Ising model on the square lattice and discuss its $T=0$ groundstates. The MC simulation methods are described in section \[sec:methods\] and results are presented in section \[sec:results\]. We conclude with a summary and outlook in section \[sec:discussion\]. Model \[sec:model\] ------------------- We study the classical Ising model with competing antiferromagnetic interactions $J_1$ on the NN bonds and $J_2$ on the NNN bonds ($J_i > 0$): $$\begin{aligned} H = J_1 \sum_{\text{NN}} S_i S_j + J_2 \sum_{\text{NNN}} S_i S_j \, , \quad S_i =\pm1 \, . \label{eq:En}\end{aligned}$$ We will study square lattices of linear extent $L$ with periodic boundary conditions. For $J_2 = 0$ the groundstate of (\[eq:En\]) is the known antiferromagnetic solution which is a Néel ordered lattice (see Fig. \[fig:degeneracy\], left) with energy $E = -2 J_1 N$ ($N = L^2$ is the number of sites). Switching on the repulsive interaction on the diagonal (NNN) bonds of the square lattice yields an increase of the groundstate energy for the Néel-ordered state: $$\begin{aligned} E_{\text{N\'eel}} = -2 N (J_1-J_2) \, .\end{aligned}$$ For large $J_2$ the system orders in the collinear (or superantiferromagnetic) phase (see Fig. \[fig:degeneracy\], right) where all diagonal bonds are antiferromagnetic, while half of the NN bonds is antiferromagnetic and the other half is ferromagnetic. Thus, the energy in this state depends only on $J_2$: $$\begin{aligned} E_{\text{Coll}} = -2 N J_2 \, .\end{aligned}$$ The critical point separating these two phases lies at $J_2 = J_1/2$, where the transition temperature is suppressed to $T=0$. At this point the groundstate is highly degenerate. More precisely, there are $2^{L+1}-2$ groundstates which can be obtained as follows: flipping a line of antiparallel spins costs no energy at $J_2 = J_1/2$. Thus, one can generate almost $2^{L+1}$ groundstates from a Néel state by flipping either the $L$ horizontal or the $L$ vertical lines independently (the second Néel state can be reached in both ways). In particular, one can reach a collinear state through a series of intermediate groundstates by $L/2$ line flips, as sketched in Fig. \[fig:degeneracy\]. Accordingly, close to the critical point $J_2 = J_1/2$ the energy landscape is characterized by many local minima which are separated by large energy barriers. Therefore, MC simulations using only single-spin flips have problems to reach the configuration with global minimum energy. To solve this problem and to obtain transition temperatures also in the vicinity of $J_2 = J_1/2$ we implemented improved MC algorithms which we will discuss in the next section. Methods \[sec:methods\] ======================= Computational methods \[sec:comp\] ---------------------------------- We first tried to simulate the model with competing interactions using conventional single-spin flip MC simulations [@B:landaubinder]. However, near the critical point this algorithm does not provide proper results and suffers severe freezing problems in the proximity of the critical temperature and below. To overcome these problems we implemented a parallel tempering algorithm [@P:huku96; @P:marinari98; @P:hans97; @P:trebst06]: a number of simulations with the same set of parameters ($J_1$, $J_2$, $L$) but varying temperatures are simulated simultaneously. After a sufficiently large number of sweeps over the complete lattice an additional MC step proposes a configuration swap between neighbouring simulations with an acceptance rate $p(i,i+1)$: $$\begin{aligned} p(i,i
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187, 187, 2377, 4792, 8399, 15, 4923, 1457, 437, 369, 2256, 281, 1097, 8399, 14, 5251, 5459, 13, 253, 187, 187, 3299, 42, 8521, 9433, 253, 2169, 13, 12360, 5249, 6424, 8399, 1268, 273, 5910, 15, 187, 187, 5035, 530, 15, 52, 15, 52, 15, 40, 15, 3015, 577, 35, 18, 15, 21, 9, 67, 10, 313, 249, 2855, 272, 253, 3286, 1302, 281, 4647, 253, 8399, 1268, 187, 187, 3529, 310, 253, 6459, 481, 535, 50271, 4553, 247, 1264, 1268 ]	for species of conservation concern" that represent habitats in a significant state of decline. Recommendation: To improve NRCS's implementation of the Conservation Security Program, the Secretary of Agriculture should direct the Chief of NRCS to include a reference to the national guidance for wildlife habitat assessment criteria in NRCS's Conservation Programs Manual. Agency Affected: Department of Agriculture Status: Closed - Implemented Comments: According to Natural Resources Conservation Service (NRCS) officials, the agency directed its state offices to submit a copy of their wildlife habitat assessment criteria for all proposed Conservation Security Program (CSP) watersheds. These criteria were examined for consistency with NRCS's national CSP guidance [i.e., minimum national eligibility criteria for wildlife habitat] by the Deputy Chief for Science and Technology's National Biology Team in Ft. Worth, Texas. Discrepancies with the national guidance were resolved in cooperation with the relevant NRCS State Conservationists. Recommendation: To improve NRCS's implementation of the Conservation Security Program, the Secretary of Agriculture should direct the Chief of NRCS to review and field check each NRCS state office's wildlife habitat assessment criteria to ensure that states use consistent criteria and achieve the habitat benefits intended by the national guidance. Agency Affected: Department of Agriculture Status: Closed - Implemented Comments: According to the Natural Resources Conservation Service (NRCS), it created an automated system within its ProTracts contracting software to compare existing Wildlife Habitat Incentives Program, Agricultural Management Assessment, and Environmental Quality Incentives Program (EQIP) contracts with existing CSP contracts to reveal potential areas of overlapping conservation practices and payments. Using this system, NRCS officials indicated in March 2009 that they had identified more the 370 duplicate payments between CSP and EQIP totaling about $420,000. NRCS indicated that these cases of duplication were dealt with according to the NRCS contracting manual, although the agency did not identify the amount of duplicate payments recovered. In addition to creating this automated system, NRCS issued National Bulletin 300-7-1, Conservation Security Program (CSP) Potential Duplicative Payments, to enlist the assistance of its state offices to identify potential or actual duplicate payments between CSP and other programs, and to take action to modify contracts to preclude duplicate payments or recover duplicate payments already made. The bulletin notes that despite statutory provisions and previous NRCS actions to prevent CSP from duplicating other programs, GAO found that the potential for duplicate payments still exists and such payments have occurred. Among other things, the bulletin directs the state offices to compare conservation activities under CSP contracts with those under contracts related to other programs to determine whether duplicate payments are planned or have occurred. The bulletin also provides guidance on recognizing situations that constitute duplication, including examples of conservation activities under CSP and another program that would or would not be considered the same. In addition, the bulletin requires each state office to complete a Potential Duplicate Report and submit it to the Director of NRCS's Financial Assistance Programs Division. Recommendation: To improve NRCS's implementation of the Conservation Security Program, the Secretary of Agriculture should direct the Chief of NRCS to develop a process to efficiently review existing CSP contracts to identify cases where CSP payments duplicate payments made under other programs and take action to recover appropriate amounts and to ensure that these duplicate payments are not repeated in fiscal year 2006 and beyond.For Zealong Organic Dark oolong tea, longer roasting gives these leaves a rich, deep taste and a hint of charcoal on the nose, yet no bitterness. Perfect for lovers of whole leaf, these leaves are packed in vacuum-packed foil and housed in a slim, low-profile bookshelf style package designed to protect the integrity of whole leaf. Utmost care has been taken to ensure that leaves arrive intact to deliver exceptional flavours across multiple infusions. You may also like… Perfect for lovers of whole leaf, these leaves are packed in vacuum-packed foil and housed in a slim, low-profile bookshelf style package designed to protect the integrity of whole leaf. Utmost care has been taken to ensure that leaves arrive intact to deliver exceptional flavours across multiple infusions. For Zealong Organic Aromatic oolong tea, leaves are briefly roasted at high temperatures, producing a clear aroma and taste, with a hint of fruit and flowers. Perfect for lovers of whole leaf, these leaves are packed in vacuum-packed foil and housed in a slim, low-profile bookshelf style package designed to protect the integrity of whole leaf. Utmost care has been taken to ensure that leaves arrive intact to deliver exceptional flavours across multiple infusions. The ideal gift for the tea connoisseur! The whole Zealong organic tea range at an attractive price, including Pure, Aromatic, and Dark oolong teas, as well as our extremely popular Green and Black teas. For Zealong Organic Pure oolong tea, these sweet, fresh-tasting leaves are unroasted, bringing out the pure, natural flavour of the tea. Perfect for lovers of whole leaf, these leaves are packed in vacuum-packed foil and housed in a slim, low-profile bookshelf style package designed to protect the integrity of whole leaf. Utmost care has been taken to ensure that leaves arrive intact to deliver exceptional flavours across multiple infusions. Case: 14-11131 Date Filed: 09/30/2014 Page: 1 of 10 [DO NOT PUBLISH] IN THE UNITED STATES COURT OF APPEALS FOR THE ELEVENTH CIRCUIT ________________________ No. 14-11131 Non-Argument Calendar ________________________ D.C. Docket No. 5:13-cr-00009-WTM-JEG-1 UNITED STATES OF AMERICA, Plaintiff-Appellee, versus RUSSELL JAY NEWELL, Defendant-Appellant. ________________________ Appeal from the United States District Court for the Southern District of Georgia ________________________ (September 30, 2014) Before TJOFLAT, HULL and JORDAN, Circuit Judges. PER CURIAM: Case: 14-11131 Date Filed: 09/30/2014 Page: 2 of 10 After pleading guilty, Russell Jay Newell appeals his total 188-month sentence for possession of a firearm by a convicted felon, in violation of 18 U.S.C. § 922(g)(1) (Count 1), and possession with intent to distribute methamphetamine, in violation of 21 U.S.C. § 841(a)(1) and (b)(1)(C) (Count 2). On appeal, Newell contends his sentence is unreasonable. After review, we affirm. I. BACKGROUND On July 18, 2013, Newell pled guilty to both counts. Subsequently, the government discovered that Newell had three qualifying prior convictions under the Armed Career Criminal Act (“ACCA”), 18 U.S.C. § 924(e). The government filed an unopposed motion asking the district court to hold a supplemental plea hearing to advise Newell that he was subject to the ACCA’s increased 15-year mandatory minimum and life maximum penalties. On January 6, 2014, the district court held a supplemental plea hearing, at which Newell re-entered his guilty plea. Newell’s Presentence Investigation Report (“PSI”) listed three juvenile convictions and nine adult convictions in the state of Georgia. Newell’s adult convictions included: (1) a 1997 conviction for theft by receiving stolen property; (2) 1997 convictions for theft by taking and burglary; (3) a 1998 conviction for burglary; (4) a 2005 conviction for possession of methamphetamine; (5) a 2009 conviction for giving false information to a law enforcement officer; (6) a 2009 conviction for manufacturing methamphetamine; (7) a 2011 conviction for 2 Case: 14-11131 Date Filed: 09/30/2014 Page: 3 of 10 criminal damage to property; (8) 2011 convictions for fleeing or attempting to elude, and giving false information to, a law enforcement officer; and (9) a 2012 conviction for theft by receiving stolen property. As to Count 2, the PSI recommended that, based on Newell’s 1998 burglary and 2009 methamphetamine manufacturing convictions, Newell was a career offender, pursuant to U.S.S.G. § 4B1.1(b)(3), with an offense level of 32. As to Count 1, the PSI recommended that, based on those same two convictions and Newell’s 1997 burglary conviction, Newell was an “armed career criminal” under 18 U.S.C. § 924(e) and U.S.S.G. § 4B1.4(b)(3)(A), which resulted in an offense level of 34 because Newell had possessed a firearm in connection with a controlled substance offense. Because Newell was subject to both offense-level increases, the PSI recommended applying the higher, armed career criminal offense level of 34. See U.S.S.G. § 4B1.4(b) (instructing the district court to apply the offense level that is the greatest). After a three level
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731, 13, 6926, 14184, 310, 417, 562, 281, 29254, 390, 4274, 3938, 9596, 15, 187, 187, 4877, 55, 1838, 388, 18174, 1267, 1139, 27, 1422, 871, 13, 309, 1053, 626, 2868, 275, 2656, 15 ]	I don't necessarily have to believe what you believe, but we won't tell you what to believe — you know, props for that. Respect. Total respect for that," Alumit says. This was exactly the intent of Sanderson Jones and Pippa Evans when they started Sunday Assembly in the United Kingdom. "There are loads of people out there who want to live better, help often and wonder more," Jones says in a crowdfunding video pitching their idea for godless congregations. "It's all the best bits of church, but with no religion and awesome pop songs," Evans says. "And it's not a cult," Evans adds. "But that's exactly what we'd say if it were a cult," the pair deadpan. This lighthearted approach seems to be reaching a growing number of nonreligious people. "This is a big boom now of secularity — people not wanting to associate with religion, not wanting to identify as religious," says Phil Zuckerman, who teaches about secularism at Pitzer College in Southern California. Zuckerman says his research shows that 20 percent of Americans say they are nonreligious. And among people younger than 30 years old, that number is 30 percent, he says. "Some people who were raised with religion rejected it for certain reason that leaves them with a bitter taste in their mouth about religion: either they had bad experiences in their church, or they saw hypocrisy in the youth pastor, or they felt that religion was manipulative or all the litany of reasons people might not like religion," Zuckerman says. "Those people are a little bit angry at religion." He says Sunday Assembly appeals to more optimistic atheists — those hoping to re-create what they felt was good about religion. "They miss the community, they miss the music, they miss the multigenerational coming together with people that you might not otherwise be hanging out with," he says. "But they don't want to go to a place where they have to keep their intellect on hold. They don't want to push pause on the skepticism button in their mind." Aiming To Stay Dogma-Free Zuckerman notes that there have been secular organizations for years, like the Ethical Culture Society, American Atheists, Humanist centers, some nondogmatic Unitarian chapters and organizations fighting for political and social causes. But unlike some of these groups, he says, Sunday Assembly is not out to critique or debunk religion. That approach is what drew TV animator David Hernston, 38, and retiree Valerie Stansfield, 75. "I don't believe in God, and so going to church, even with Unitarian church, it's not so explicitly God-y, but there's still some spirituality that just doesn't resonate for me at all, so I've been hoping for this sort of community experience for a long time," Hernston says. "I think it will grow," Stansfield says. "There's a lot of people who feel spiritual, they want the spiritual feelings, they want the celebration. It's natural. All humans love it." Ian Dodd, one of the co-founders of LA's Sunday Assembly chapter, is a camera operator for TV shows like Community and True Blood by day. "I got involved with Sunday Assembly about last February or March when I first started seeing the stories online about the London assembly. And by August we had a website and a YouTube channel, and we had 900 people signed up ahead of time, and here we are at our second assembly. We take our nonbelief as a beginning point, not an end point," he says, "because this is the here and now, and this is all we can count on. What is it we're going to do to make a difference here?" The members in Los Angeles were encouraged to volunteer to read to children at a downtown elementary school, to donate blood and to plant some trees with a local charity organization. In addition to Sunday Assembly, Dodd is a member of the Unitarian church in Santa Monica. He was once a practicing Buddhist who also dabbled in various New Age philosophies. "As a young adult, I went off on my exploration and checked out this and that and tried to find something that was bigger than myself," he says. "And I discovered that the universe in itself is bigger and more fantastic and more awe-inspiring than any story that human beings have ever created for themselves." Dodd does acknowledge that Sunday Assembly is not without its factional schisms, like many religions. He says the newly formed chapter in New York has already split over how much to emphasize atheism. But he says the Los Angeles group is staying away, for now, from any kind of dogma, pro or con. Copyright 2014 NPR. To see more, visit http://www.npr.org/. Transcript RENEE MONTAGNE, HOST: Let's hear now about Sunday Assembly. It's the brainchild of two British comedians who started a church for people who don't believe in God. They launched Sunday Assembly just a year ago and already its spread across the globe. In this country, there are now around 30 Sunday Assembly chapters. MANDALIT DEL BARCO, BYLINE: It sometimes feels like church in the auditorium of the Professional Musicians Union in Hollywood. (SOUNDBITE OF GUITAR MUSIC) BARCO: Hundreds of people are gathered on a Sunday morning to meditate, listen to inspirational poetry and stories, and to sing. UNIDENTIFIED MAN #1: The words going to be on the screen. (SOUNDBITE OF SONG, "REVOLUTION") UNIDENTIFIED MAN #2: (Singing) You say you want a revolution... BARCO: There's a live band performing songs by the Beatles, the Rolling Stones and Jerry Lee Lewis. And instead of a sermon, there's a lecture by experimental psychologist and neuroscientist Jessica Kale about the biology of gender identification and sexual orientation. JESSICA KALE: What I want to get across is gender is a spectrum. It's not a binary thing. We've got manly men, we've got girly girls, and we've got everything in between. And I think we all kind of accept that we're somewhere in between these two. BARCO: Mostly at the Sunday Assembly, there is no God talk. That appealed to divinity student Noel Alumit. NOEL ALUMIT: I don't necessarily have to believe what you believe, but we won't tell you what to believe - you know, props for that, respect. Total respect for that. You know... (LAUGHTER) ALUMIT: ...total respect for that. BARCO: That was exactly the intent of Sanderson Jones and Pippa Evans when they started Sunday Assembly. SANDERSON JONES: It turns out there are loads of people out there who want to live better, help often and wonder more... BARCO: In an online crowd funding campaign video, the two British comedians talk about their idea for gathering self-proclaimed godless congregations. PIPPA EVANS: It's all the best bits of church but with no religion and awesome pop songs. JONES: It's a celebration of life. EVANS: And it's not a cult. SANDERSON JONES AND PIPPA: But that's exactly what we'd say if it were a cult. (SOUNDBITE OF EERIE MUSIC) BARCO: This lighthearted approach seems to be reaching a growing number of nonreligious people. PHIL ZUCKERMAN: This is a big now - a big boom of secularity. People not wanting to associate with religion, not wanting to identify as religious. BARCO: Phil Zuckerman teaches about secularism at Pitzer College in Southern California. He's also the author of the books "Faith No More" and "Society without God." He says his research shows that 20 percent of Americans today report being non-religious. And among Americans younger than 30 years old, that number is 30 percent. ZUCKERMAN: Some people who were raised with religion reject it for certain reasons that leaves them with a bitter taste in their mouth about religion. Either they had bad experiences in their church or they saw hypocrisy in the youth pastor, or they felt that their religion was manipulative - or all the litany of reasons people might not like religion. Those people are a little bit angry at religion. BARCO: But Zuckerman says Sunday Assembly appeals to the more optimistic atheists, those hoping to recreate what they felt was good about religion. ZUCKERMAN: They miss the community. They miss the music. They miss the multi-generational coming together with people that you might not otherwise be hanging out with. But they don't want to go to a place where they have to keep their intellect on hold. They don't want to push pause on the skepticism button, you know, in their mind. BARCO: Zuckerman notes that for years there have been secular organizations, like the Ethical Culture Society, American Atheists and various humanist centers. But he says unlike some of them, Sunday Assembly is not out to critique or debunk religion. DAVID HERNSTON: You know, I don't believe in God.
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1916, 32, 187, 187, 11752, 643, 5989, 13, 436, 651, 2686, 320, 11755, 15, 844, 2080, 1512, 7744, 4763, 16530, 432, 2758, 665, 564, 281, 6832, 3434, 281, 1056, 2119, 597, 452, 2530, 247, 43713, 7000, 8813, 273, 616, 1895, 390, 1953 ]	consistent with a lot of art neuvea and deco touches, hand-painted texture work and a great attention to detail. Double Fine’s previous games have shown the same love, and it’s good to see they haven’t skimped just because it’s a cheaper, lower profile title. Each of the dolls has a lot of personality and the animation is spectacular considering the dolls have no posable arms, legs, or, well.. Anything! The sound is perfectly suited too, from the funny little noises the characters make, the steam and clattering of machinery. Perhaps the game would have benefitted from a little more music during gameplay? That’s probably just a personal preference. The music that IS there is in-fitting with the era and enhances the mood. Gameplay: Charlie is controlled from a standard 3rd person view (right stick pans camera) The game centres around a hub-world like train station, allowing you to revisit any levels to unlock extra rewards and mess around. As you complete each scenario a new platform or train becomes accessible in the station. Cleverly little shrines are built in the station documenting your progress throughout the game, complete with murals and a visual record of the dolls you’ve used. It’s a lovely little touch as it makes your achievements in the game seem much more tangible. I’d like to see this sort of thing in other games. Each level consists of a location, say a cruise ship – with a few main puzzles which can all be solved in multiple (usually 4+) ways. Each of the puzzles depends on clever use of each of the stacking dolls’ abilities. With more than 100 different dolls ranging from rats and mummies to socialites and musicians – each of the dolls has its own specific skill. Charlie can only stack into a doll of the next size up, and so on, so you find yourself shuffling around between different dolls, sometimes needing two dolls’ skills to complete a puzzle. The concept is pretty hard to explain, so here’s some gameplay in an official trailer. For old-timers – the core gameplay is similar to Paradroid, though much more accessible and with no danger of death/failure. As a result – the level of challenge in Stacking is.. Well, there isn’t really much of a challenge. It’s quite a stress free (casual?) experience. Running through the main story will likely not take you more than four hours in a single play-through. Most of the value comes from messing around and trying to think up new ways to solve each of the puzzles. Much of the dialogue and situations that play out as you interact with the dolls is very entertaining and well worth the extra time. There are even mini achievements labelled “hijinks” asking you to do lots of dumb things, rewarding you with prettified dolls. eg; you might have to head-butt 10 different dolls, or shake a lot of people’s hands. Conclusion: All in all as a complete package at a good price Stacking is a gem of a title as long as you don’t expect long term challenge. I enjoyed it thoroughly and it’s actually refreshing to be able to complete a game within a reasonable period of time, knowing I can dip back into it and unlock further stuff. This seems ideal for a downloadable title of this kind. It’s not so long it drags, but it could probably have done with some advanced challenges as an optional aside. Portal is a good example – a short puzzle game with an obvious progression through a pretty easy campaign with the hard challenges unlocked at the end. As it is, Stacking is not going to appeal to some players, though I’d urge you to try it out and support Double Fine’s original efforts. N.B: This month Stacking is FREE to members of PlayStation Plus, so obviously that’s worth downloading.. As for other buyers – if you like the style and think you’d enjoy the gameplay you’re not likely to find such a fun, if short diversion. Notes: Played once through the PS3 version. Still have to 100% all the unlockables and achievements. As far as I’m aware there is no difference between PS3 and ‘360 versions, so count the review as both.Forum and Social Media Guidelines – 2/26/13 The following are the guidelines for this Forum and all NACA social media, including Facebook, Twitter, NACA Radio and Live Chat: The following rules have always been posted near the top of the Forums page on the forum website at http://forums.naca.com, just above the links to the five forum categories: “Welcome to the NACA Forums! Please keep in mind that this is a public forum. Any derogatory, inflammatory or questionable content will be removed by administrators. Also, please DO NOT post any personal information, such as passwords, NACA ID numbers, or Social Security numbers; NACA Staff will never require this information on the Forums.” Disregard for the rules and other abuses of the forum and social media in general is not tolerated. Such activity hinders the effectiveness of the NACA social media efforts as tools for asking questions, sharing information and for those who are seeking help with problems in either the Home Save or Purchase programs. To prevent such abuses, the following rules apply for all NACA social media: F(orum) comes before E(mail): Maybe not in the alphabet, but here in the forum, F comes before E. In other words, please post your question in the Forum rather than circumvent the system and send an Email to an address you happen to find in the forum. The forum exists for several purposes, not the least of which is the sharing of information that may be beneficial to many of our members. Most of the questions we receive are more generic in nature than most people think. By posting a question in the Forum first, it can be most likely answered here in the Forum unless it involves specific information in your file. By handling the question or problem here whenever possible, other members experiencing a similar problem could get the answer and help they need more quickly and without making a single additional keystroke. If your post does require specific information, you will be advised on the best means of contact with us so any personal information can be communicated securely and confidentially. The NACA Live Chat function on the home page of the NACA website can also be used to securely ask specific questions regarding your file. The Forum Does Not Replace NACA Services: This Forum and other social media channels iare in no way a substitute for NACA Counseling and Advocacy services whether in the Home Save or Purchase Programs, and information found here should not be considered a replacement for communicating with a NACA counselor. While much of the information here is general in nature and applicable to most situations, specific questions regarding your file cannot be addressed in this or any other public forum for privacy reasons. Additionally, every file has unique factors and issues of its own. Therefore, you should always attempt to communicate your questions and concerns with your Mortgage Consultant in the Purchase Program and with a Counselor, Negotiator or Member Services rep in the Home Save program. Plus, the new NACA Live Chat function on the home page at www.naca.com allows you to contact a NACA staff member and communicate real-time to seek answers to your questions regarding your file. Our Member Services Department can be reached at 425-602-6222. The Member Services and Live Chat Teams are available from 8am to 10 pm Eastern Time Monday through Friday. Keep it Civil: Another serious issue is the tone used in some messages. We eagerly invite anyone who is having what they perceive to be any sort of problem with the NACA process or on line system to use this Forum and social media channels as a means of reaching out to us with those concerns so we can help solve them in whatever way we can. However, please remember to compose your message in the same manner in which you would like to receive the response. As noted above, “derogatory, inflammatory or questionable content” has always been grounds for posts to simply be deleted. This includes sarcasm as well as insulting and accusatory statements. The NACA Membership Agreement states that you agree to not engage “in any conduct deemed by NACA to be harmful, threatening, demeaning, or contrary to its interests, staff, mission and agents…”. Determination of what content is considered inappropriate is at the sole discretion of the administrators of the NACA Forum and other NACA social media channels. While we are in fact eager to help with any problems that may occur, if you can’t write without being cynical, you may want to hold off a bit until you can be more rational in expressing your concerns. No Personal Information: While this one should be common sense, it is surprising how many people will post their name, NACA ID number and even their telephone number in a forum post or even on Facebook. Please remember that what you write here can be read by anyone on the internet. This is not a membership-restricted site, so please do not post any information about yourself here that you would not announce over a microphone to a crowd of twenty thousand people. Again, that personal information starts with and includes your NACA ID number. Never post it or any other personal information in a public forum, here or anywhere else on the web. Oh, By the Way, Who Am I Talking To? Under other circumstances, this would actually be funny. We far too commonly receive emails from members who go to substantial effort to make sure they have provided a wonderfully detailed explanation of their problem or question
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She understood, more than any of the others, that I could play only the songs I had copied from Kovich. Jewell, to the end, thought I could read music, and Taber even brought me hardcopies from Solfatara. Pearl simply said the names of songs, and I played them if I knew them. She never asked for one I didn't know, and I thought that was because she listened carefully to the tappers' requests and my refusals, and I was grateful. I sat down at the pianoboard and looked at Pearl in the mirror. I had asked Jewell for the mirror so I could see over my shoulder. I had told her I wanted it so she could signal me songs and breaks and sometimes the ropecutter if the men got rough or noisy, but it was really so I could keep Taber from standing there without my knowing it. "'Back Home,'" Pearl said. I could hardly hear her over the nitrogen blowers. I began playing it, and Taber came in. He walked swiftly over to her and then stood quite still, and between my playing and the noise of the blowers, she did not hear him. He stood about half a meter from her, close enough to touch her but just out of reach if she had put her hand out to try to find him. He took the cigar out of his mouth and bent down as if he were going to speak to her, and instead he pursed his lips and blew gently at her. I could almost see the smoke. At first she didn't seem to notice, but then she shivered and drew her shinethread shawl closer about her. He stopped and smiled at her a moment and then reached out and touched her with the tip of his cigar, lightly, on the shoulder, as if he intended to burn her, and then darted it back out of her reach. She swatted at the air, and he repeated the little pantomime again and again, until she stood and put her hands up helplessly against what she could not see. As she did so, he moved swiftly and silently to the door so that when she cried out, "Who is it? Who's there?" he said in his slow drawl, "It's me, Pearl. I've just come in. Did I frighten you?" "No," she said, and sat back down again. But when he took her hand, she flinched away from him as I'd thought she would from me. And all the while I had not missed a beat of the song. "I just came over to see you for a minute," Taber said, "and to hear your pianoboard player. He gets better every day, doesn't he?" Pearl didn't answer. I saw in the mirror that her hands lay crossed in her lap again and didn't move. "Yes," he said, and walked toward me, flicking imaginary ashes from his unlit cigar onto my hands. "Better and better," he said softly. "I can almost see my face in you, Mirror." "What did you say?" Pearl said, frightened. "I said I'd better go see Jewell a minute about some business and then get back next door. Jack found a new hydrogen tap today, a big one." He went back through the card room to the kitchen, and I sat at the pianoboard, watching in the mirror until I saw the kitchen door shut behind him. "Tabar was in the room the whole time," I said. "He was... doing things to you." "I know," she said. "You shouldn't let him. You should stop him," I said violently, and as soon as I said it I knew that she knew that I had not stopped him either. "He's a very bad man," I said. "He has never locked me in," she said after a minute. "He has never tied me up." "He has never known how before," I said, and I knew it was true. "He wants me to find out for him." She bent her head to her hands, which still lay crossed at the wrists, almost relaxed, showing nothing of what she was thinking. "And will you?" she said. "I don't know." "He's trying to get you to copy him, isn't he?" she said. "Yes." "And you think it's working?" "I don't know," I said. "I can't tell when I'm copying. Do I sound like Taber?" "No," she said, so definitely that I was relieved. I had listened to myself with an anxious ear, hoping for Jewell's shortened vowels and tapper slang, waiting in dread for the slow, lazy speech of Taber. I did not think I had heard either of them, but I had been afraid I wouldn't know if I did. "Do you know who I'm copying?" I said. "You walk like Jewell," she said, and smiled a little. "It makes her furious." It was the end of the shift before I realized that, like my uncle, she had not really answered what I had asked. Jack's new tap turned out to be so big that he needed a crew to help put up the compressors, and for several shifts hardly anyone was in the house, including Taber. Because business was so slack, Jewell even let some of the girls go over to the gaming house. Taber didn't go near the tap, but he didn't come over quite so often either, and when he did, he spent his time upstairs or with Carnie, talking to her in a low voice and clicking the speaker over and over again, as if he could not help himself. Then, once the compressors were set up and the sidon working, the men poured back into St. Pierre, and Taber was too busy to come over at all. The one time he came, he found Pearl alone with me, he said, "It's Taber, Pearl," almost before I had banged a loud chord on the keys and said, "Taber's here." He did not have his cigar with him, or his sparker, and he did not even speak to me. Watching Pearl talk to him, her head gracefully turned away from him, her hands in her lap, I could almost believe that he would not succeed, that nothing could hurt her, safe in her blindness. We were so busy that Jewell hardly spoke to me, but when she did, she told me sharply that if I had nothing better to do than copy her, I should tend bar, and set me to passing out the watered liquor she had brought out in honor of the new sidon. She did the boards for the week herself while I ran the body checks. Pearl, naked under the scan, looked serene and unhurt. Carnie had sot-scars under her arms. I did not report her. If Jewell found out, she would send Carnie back to Solfatara, and I wanted Tabor to be working on Carnie, giving her sots and trying to get her to help him, because then I could believe he had given up on me. I did not dare believe that he had given up on Pearl, but I did not think that he and Carnie alone could hurt her, no matter what they did to her. Not without my help. Not so long as I was copying Jewell. I told Pearl about Carnie. "I think she's on sots," I said. We were alone in the music room. Jewell was upstairs, trying to catch up the boards. Carnie was in the kitchen, taking her turn at supper. "I saw what looked like scars." "I know," Pearl said, and I wondered if there was anything she did not see, in spite of her blindness. "I think you should be careful. It's Taber that's giving them to her. He's using her to hurt you. Don't tell her anything." She said nothing, and after a minute I turned back to the pianoboard and waited for her to name a song. "I was born in the happy house. My mother worked there. Did you know that?" she said quietly. "No," I said, keeping my hands spread across the keyboard, as though they could support me. I did not look at her. "I have told myself all these years that as long as no one knew what happened, I was safe." "Doesn't Jewell know?" She shook her head. "Nobody knows. My mother told them he threatened her with the sot-razor, that there was nothing she could do." The nitrogen blowers kicked on just then, and I jumped at the sound and looked into the mirror. I could see the sidon in the mirror, and standing on its red murdered skin, Taber. Carnie had let him in through the kitchen and turned the blowers up, and now he stood between the noisy blowers, smiling and flicking imaginary ash onto the carpet beside Pearl's chair. I took my hands off the keyboard and laid them in my lap. "Carnie's in the kitchen," I said. "I don't know if the door's shut." "There was a tapper who came to the house," Pearl said. "He was a very bad man, but my mother loved
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354, 14, 13901, 285, 45169, 6128, 1254, 51, 1619, 7254, 51, 1229, 5413, 534, 588, 4833, 253, 3167, 2380, 281, 1971, 285, 3021, 2818, 253, 2495, 273, 2471, 285, 2728, 15969, 15, 3774, 6856, 671, 556, 271 ]	-fn"}^ 31/173 1.0 11/173 1.0 23/173 1.0 CC 28/160 0.6 (0.4--1.1) 9/160 0.4 (0.1--1.1) 21/160 0.7 (0.4--1.2) hsa-mir-499 rs3746444 CT + CC 29/154 1.0 12/154 1.0 21/154 1.0 TT 30/179 0.6 (0.3--1.1) 8/179 0.5 (0.2--1.2) 23/179 0.8 (0.4--1.3) Patients treated with chemoradiation (N = 663) hsa-mir-146a rs2910164 CG + CC^[b](#tfn_007){ref-type="table-fn"}^ 103/306 1.0 67/303 1.0 86/306 1.0 GG 132/357 1.0 (0.8--1.3) 65/360 0.8 (0.5--1.1) 94/357 0.9 (0.7--1.2) hsa-mir-196a2 rs11614913 CT + TT^[b](#tfn_007){ref-type="table-fn"}^ 124/369 1.0 70/366 1.0 94/369 1.0 CC 111/294 1.1 (0.9--1.4) 62/297 1.0 (0.8--1.4) 86/294 1.0 (0.8--1.3) hsa-mir-149 rs2292832 CT + TT^[b](#tfn_007){ref-type="table-fn"}^ 136/337 1.0 72/332 1.0 102/337 1.0 CC 99/326 0.6 (0.3--0.8) 60/331 0.7 (0.5--1.0) 78/326 0.6 (0.3--0.9) hsa-mir-499 rs3746444 CT + CC^[b](#tfn_007){ref-type="table-fn"}^ 133/298 1.0 68/293 1.0 94/298 1.0 TT 102/365 0.6 (0.4--0.9) 64/370 0.5 (0.4--0.8) 86/365 0.5 (0.3--0.7) Adjusted for age, sex, ethnicity, smoking status, alcohol use status, stage, and comorbidity. Reference group. DISCUSSION {#s3} ========== Our results demonstrate the association between certain pre-miRNA polymorphisms and survival among patients with SCCNOP. We found that patients with the hsa-mir-149 CC and hsa-mir-499 TT genotypes had a significantly lower risk of death and disease recurrence than did patients with the corresponding variant genotypes. Furthermore, we found that these significant associations were restricted to the patients who were ever smokers and the patients treated with radiation and/or chemotherapy with or without surgery. These results suggest that the hsa-mir-149 and hsa-mir-499 polymorphisms predict prognosis in patients with SCCNOP, particularly in some subgroups, which may help physicians develop individualized treatment plans that improve survival and quality of life for patients with this disease. If the associations between these polymorphisms and SCCNOP death and disease recurrence are confirmed, clinicians could use these functional polymorphisms as biomarkers to identify an important subgroup of patients who are at high risk of death or recurrence. It is likely that future targeted therapies will be designed (in part) to counteract the effects of significant SNPs as well as individualized within the SCCNOP subgroup. Furthermore, it may be possible to intensify treatment for patients in whom the adverse genotypes are identified before treatment begins, add adjuvant therapy for those with such adverse genotypes identified immediately after treatment, and intensify the workup for treatable recurrent disease or in those who are found to have a high risk of death and recurrence in follow-up. However, these potential therapeutic options would each have to be tested in clinical trials. While local or distant recurrent SCCNOP is almost always ultimately fatal, it is hoped that the earlier recurrent disease is detected the greater the chances of successfully treating such disease. Ultimately, the data from studies such as this one will improve prognostication, facilitate more selective use of systemic therapy, and hopefully, improve outcomes. It has been demonstrated that some miRNAs are upregulated in head and neck cancer cell lines and tumors, and high expression levels of these genes may be associated with cancer progression and poor outcomes \[[@R16], [@R17]\]. However, other miRNAs appear to be down-regulated, and their reduced expression may contribute to the development and/or progression of such cancers by coordinating a loss of sensitivity to ionizing radiation \[[@R18]\]. Therefore, miRNA expression patterns could be powerful biomarkers for the diagnosis and prognosis of head and neck cancers \[[@R17]\]. Genetic polymorphisms of miRNAs are one of the most important genetic alterations and are capable of causing reductions or increases in miRNA expression levels, and in turn, individual variations in the regulation of inflammatory and apoptotic responses \[[@R19]\]. Studies have suggested that miRNAs are critical in mediating inflammatory response in vitro and in vivo \[[@R20]\]; and they have both anti-inflammatory and pro-inflammatory actions through the regulation of inflammatory signaling pathways, targeting key elements in the pathways for the regulation of inflammatory responses to cytotoxic therapy, including chemoradiotherapy \[[@R20]\]. Functional analyses also have indicated that miRNAs are involved in the regulation of inflammatory responses and cytokine signaling \[[@R21]\]. On the other hand, miRNAs influence apoptosis through their regulation of both intrinsic and extrinsic apoptotic pathways and oncogenic and tumor suppressor networks \[[@R22]\]. Therefore, genetic alterations of miRNAs may lead to evasion of apoptosis, a mechanism that possibly leads to tumorigenesis by influencing apoptosis and cell-survival pathways through resistance to radiation. Evasion of apoptosis also may dictate the evolution of neoplastic cells. Given the roles of miRNAs as regulators of apoptosis, it is likely that miRNAs modulate sensitivity/resistance to radiation therapy in SCCNOP patients. Several studies have investigated the associations between the 4 miRNA polymorphisms in this study and cancer risk and prognosis \[[@R11], [@R12], [@R23]--[@R26]\], but none have investigated whether these 4 polymorphisms are associated with survival in SCCNOP patients. An association between miRNA polymorphisms and cancer risk and prognosis is well supported by several lines of evidence. First, our previous study suggested that these 4 pre-miRNA polymorphisms may have a joint effect on the risk of SCCHN \[[@R27]\]. The SNPs located within either the pre-miRNAs or the miRNA binding sites are in theory most likely to affect the expression of the miRNA targets contributing to cancer susceptibility and prognosis \[[@R23], [@R24]\]. Studies have evaluated the association between these same 4 SNPs and survival in cancer patients and found that hsa-mir-196a2 rs11614913 CC was significantly associated with decreased survival in non-small cell lung cancer and squamous cell carcinoma of the oropharynx (SCCOP) \[[@R11], [@R13]\]. Our previous study and others also showed that both hsa-mir-146a rs2910164 and hsa-mir-196a2 rs11614913 were significantly associated with survival in SCCOP patients \[[@R13]\]. However, in the current study, such an association was not found in SCCNOP for these 2 SNPs, and we found instead that the hsa-mir-149 and hsa-mir-499 polymorphisms were significantly associated with survival in SCCNOP. The mechanisms by which different pre-miRNAs and their target mRNAs regulate progression in different types of cancer could be different, and the subject warrants further study. For example, SCCOP is mainly driven by HPV infection, whereas SCCNOP is caused by smoking \[[@R13]\]. Although we do not know how these pre-miRNA variants influence the survival of SCCNOP, it is biologically plausible that these variants are either functional or in linkage disequilibrium with other functional variants of miRNAs or alleles at other nearby susceptibility loci. Such functional variants could increase or reduce miRNA expression levels and thus affect the regulation of inflammation and apoptotic responses. The altered regulation in these pathways might enable many cancer cells to escape or counterattack the inflammatory and apoptotic responses, leading to individual variations in inflammatory/apoptotic responses to chemoradiotherapy. The significant association was found in ever smokers but not in never smokers. This finding can be explained by the direct effect of tobacco smoking on both pro-inflammatory and immunosuppressive responses \[[@R28]--[@R30]\], which will influence the host response to treatment and thus affect the risk of death and disease recurrence. Smoking also has an
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1269, 1035, 3124, 7182, 4820, 29468, 1662, 4615, 1222, 2026, 89, 64, 18, 1337, 7718, 13, 89, 64, 47, 94, 393, 2204, 578, 74, 30, 18, 2306, 47, 362, 64, 74, 9, 89, 64, 74, 7405, 3124, 64, 74, 10, 3202, 187, 7, 246, 8048, 12183, 61, 4287, 393, 1991, 92, 51, 2306, 79, 13, 246, 64, 74, 1035, 3124, 7182 ]	(x_1,x_2,p)=1/2x_1^2+1/2x_2^2+p(x_1+x_2-1)$. Assuming that the agent $1$ is the leader in the Stackelberg game and others are followers, reaction curves are given by $x_2(x_1)=1-x_1$ and $p(x_1)=x_1-1$. Hence, suppose that agent $1$ takes a strategy to follow the following update rule instead of (\[ahu\]): $$\label{algleader} \hat{x}_1^k=\hat{x}_1^{k-1}-\gamma \frac{d}{d\hat{x}_1}u_1(\hat{x}_1,p(\hat{x}_1)).$$ With other players remaining to follow (\[ahu\]), the new dynamics leads to a Stackelberg equilibrium $(x_1^,x_2^, p^)=(1/3,2/3,-2/3)$. Notice that player $1$ achieves a smaller augmented cost $u_1^=-1/6$ at the new equilibrium, even though the distributed algorithm as a whole clearly failed to find the solution to the original resource allocation problem. In this sense, the strategy of following (\[ahu\]) by no means constitutes a Nash equilibrium. Faithful implementation of dual decomposition ============================================= We are going to introduce a monetary transfer function $t$ that incentivises followers to implement (\[ahu\]). For a sufficiently large $K$, a social decision $$x:=\hat{x}^K-R^T(RR^{T})^{-1}(R\hat{x}^K-c)$$ approximates the optimal solution of (\[originalprob\]) with an arbitrary accuracy. A natural choice of $t_i$ inspired by the Groves mechanism is then $$\label{grovestax} t_i:=\sum_{j\neq i} v_i(x_i;\theta_i).$$ Throughout the algorithm, we require the followers to report not only $x_i^k$ but also the value $v_i(x_i^k;\theta)$ so that the leader is able to perform a convergence analysis and compute $t_i$. The proposed distributed algorithm is summarized in Algorithm \[distalg\]. Note that the algorithm is parametrized by $n\in \mathbb{N}$, which guarantees the accuracy $1/n$ of the final result. \[distalg\] $\text{Problem data, step size $\gamma$ }$ $\text{Social outputs } \tilde{x}, \tilde{t}_1,\cdots,\tilde{t}_N$ $\text{(F) Initialize } \hat{x}_1, \cdots, \hat{x}_N;$ $\text{(L) Initialize and broadcast } p \text{ and } x;$ $\text{(F) Compute and report } v_i=v_i(x_i; \theta_i);$ $\text{(F) Find } \hat{x}_i=\operatorname{arg\,min}_{x_i}(v_i(x_i;\theta_i)+p^TR_ix_i)$ $\text{ and report } \hat{x}_i \text{ and } \hat{v}_i=v_i(\hat{x}_i;\theta_i);$ $\text{(L) Compute upper bound } \bar{b}=\sum_{i=1}^N v_i;$ $\text{(L) Compute lower bound } \underbar{b}=\sum_{i=1}^N(\hat{v}_i+p\hat{x}_i);$ $\text{(L) Compute constraint violation } e=R\hat{x}-c;$ $\text{(L) Update dual variable } p:=p+\gamma e;$ $\text{(L) Find nearest feasible point } x=\hat{x}-R(RR^T)^{-1}e;$ $\text{(L) Broadcast } p \text{ and } x;$ $\text{(L) Determine social decision } \tilde{x}=x;$ $\text{(L) Determine tax values }\tilde{t}_i=\sum_{j\neq i} v_i;$ Note that Algorithm \[distalg\] suggests followers’ strategies $s^n(\cdot)$ and a social output function $g^n=(\tilde{x}^n,\tilde{t}^n)$. One possible state space description of the follower’s strategy $$s_i(\theta)=\left\{(G_{i,\theta_i}^k, H_{i,\theta_i}^k): k=1,2,\cdots,K(n)\right\}.$$ is obtained by considering $y_L=(p; x)$ as the leader’s output and \[statespace\] $$\begin{aligned} &\underbrace{\left[\begin{array}{c} v_i \\ \hat{x}_i \end{array}\right]}_{z_i^k}= \underbrace{\left[\begin{array}{c} v_i(x_i) \\ \operatorname{arg\,min}_{x_i} \left(v_i(x_i)+p^TR_ix_i\right) \end{array}\right]}_{G_{i,\theta_i}^k(z_i^{k-1},y_L^{k-1})} \\ &\underbrace{\left[\begin{array}{c} v_i \\ \hat{x}_i \\ \hat{v}_i \end{array}\right]}_{y_i^k}= \underbrace{\left[\begin{array}{c} v_i \\ \hat{x}_i \\ v_i(\hat{x}_i;\theta_i) \end{array}\right]}_{H_{i,\theta_i}^k(z_i^k)}.\end{aligned}$$ The number of steps $K(n)$ is not known a priori but is finite. The strategy space $\Sigma_i^n$ for the $i$-th follower is the space of causal mappings from $y_L^0,\cdots,y_L^{K(n)}$ to $y_i^0,\cdots,y_i^{K(n)}$. This way Algorithm \[distalg\] defines a sequence of mechanisms $\{M_n\}_{n\in \mathbb{N}}$, $M_n=(g^n,\Sigma^n,s^n)$. Notice that the payment $t$ obtained in Algorithm \[distalg\] is only an approximation of the correct VCG payment because, as per (\[grovestax\]), it is computed using the final value of $x$, as opposed to the optimal social decision. Hence generally it does not guarantee incentive compatibility in the sense of Definition \[defic\]. Such a fragile aspect of the VCG mechanism is considered in [@RefWorks:108]. \[defaic\] A sequence of mechanisms $\{M_n\}_{n\in\mathbb{N}}$, $M_n=(g^n,\Sigma^n,s^n)$ is said to asymptotically implement a social choice function $f$ in ex-post Nash equilibria if for every $\delta_1>0,\delta_2>0$, there exists $N\in\mathbb{N}$ such that for any $n\geq N$, - $\\|g^n\circ s^n-f\\|<\delta_1$ - $\forall i, \forall \hat{s}_i^n\in\Sigma_i^n, \forall \theta\in \Theta$, $$\begin{aligned} &\hspace{-.2in}v_i\left(\tilde{x}_i^n\circ (s_i^n(\theta_i),s_{-i}^n(\theta_{-i})));\theta_i\right) +\tilde{t}_i^n\circ (s_i^n(\theta_i),s_{-i}^n(\theta_{-i})) \\ &\hspace{-.2in}< v_i\left(\tilde{x}_i^n\circ (\hat{s}_i^n,s_{-i}^n(\theta_{-i}));\theta_i\right) +\tilde{t}_i^n\circ (\hat{s}_i^n,s_{-i}^n(\theta_{-i})) +\delta_2.\end{aligned}$$ In this case, $\{M_n\}_{n\in\mathbb{N}}$ is said to be asymptotically incentive compatible. For a fixed $n\in \mathbb{N}$, $M_n$ is not incentive compatible. However, as $n\rightarrow \infty$, $M_n$ provides every follower a diminishing incentive to deviate from the suggested slave algorithm. \[tho:1\] Assume that $v_i(\cdot;\theta_i), i=1,2,\cdots,N$ are strictly convex for every $\theta_i\in\Theta_i$, and define a social choice function $f=(x,t)$ by $$\begin{aligned} & x:\Theta\rightarrow X, x(\theta)=\operatorname*{arg\,min}_{x_1,\cdots,x_N} \sum_{i=1}^N v_i(x_i;\theta_i) \\ & t:\Theta\rightarrow \mathbb{R}^n, t_i(\theta)=\
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19, 393, 918, 3117, 4880, 6274, 45677, 423, 92, 2132, 2138, 380, 4737, 273, 11506, 275, 18292, 8339, 4518, 2722, 326, 604, 247, 1677, 1375, 28096, 253, 11370, 3891, 3241, 2158, 14, 1206, 9014, 352, 310, 37434, 494, 432, 378, 281, 329, 13, 285, 671, 326, 627, 2226, 247, 873, 273, 30688, 4985, 84, 326, 28096, 253, 11370, 3891, 45, 3322, 14, 3241, 254, 3851, 347, 973, 15, 844, 1918, 690, 4278, 327, 849, 281, 10173, 253, 15355, 2193, 273, 30688, 4985, 84, 323, 247, 1677, 1375, 275, 18292, 8339, 15, 187, 187, 3138, 8486, 2441, 273, 37434, 1430, 323, 247, 2957, 90, 14299, 1375, 1754, 327, 253, 17705, 275, 5150 ]	hat r}_i \rangle \langle \Delta {\hat r}_j \rangle ,$$ with ${\hat r}_i \in \left\{{\hat X}_1,{\hat P}_1,{\hat X}_2,{\hat P}_2,\cdots,{\hat X}_{M+N},{\hat P}_{M+N} \right\}$ and $\Delta {\hat r}_k={\hat r}_k-\langle {\hat r}_k \rangle$. $ \gamma_{A} $ and $\gamma_{B}$ are $2M \times 2M $, $2N \times 2N $ real symmetric positive matrices representing local statistics of $M$- and $N$-modes, respectively. $C$ is a $ 2M \times 2N $ real matrix representing correlation between two subsystems. Due to the uncertainty principle, the covariance matrix must satisfy $\gamma_{AB} \pm i \Omega_{AB} \geq 0$, where $ \Omega_{AB} =\oplus_{i=1}^{M+N} \left( \begin{array}{cc} 0 & 1 \\ -1 & 0 \\ \end{array} \right) $ is the sympletic form [@Simon]. For the case of a two-mode Gaussian state, the covariance matrix can always be brought to a standard form by local Gaussian operations [@Duan00; @Simon00] $$\label{scova} \gamma _{AB} = \left( \begin{array}{cc} \gamma_A & C \\ C^T & \gamma_B \\ \end{array} \right) = \left( \begin{array}{cccc} a & 0 & c_1 & 0 \\ 0 & a & 0 & - c_2 \\ c_1 & 0 & b & 0 \\ 0 & - c_2 & 0 & b \\ \end{array} \right) .$$ Without loss of generality, we may set $ c_1 \geq \left\| c _2 \right\| \geq 0 $.\ Under Gaussian measurements, a Gaussian state $ \rho_{AB} $ is non-steerable from $B$ to $A$ iff $$\label{GC} {\gamma _{AB}} + i{\Omega _A}\oplus{{\bf 0}_B} \ge 0,$$ where $ {\bf 0}_{B} $ is a $ 2N \times 2N $ null matrix [@Wiseman07]. We now introduce our non-Gaussian steering criterion based on a set of local orthogonal observables, which we use to detect the steerability of two-mode Gaussian states. [Lemma]{}: Let us choose a collection of $n^2$ observables $\left\{ A^{(n)} \right\} = \left\{ \lambda_k,\, \lambda_{kl}^{\pm} \right\}$ $\left( k,l=0,1,...,n-1 \right) $ where $$\begin{aligned} \lambda_k&=& \|k\rangle \langle k \|\\ \lambda_{kl}^{+}&=&\frac{\|k \rangle \langle l\| +\|l \rangle \langle k\| }{\sqrt{2}}\,\, \left( k < l \right), \\ \lambda_{kl}^{-}&=&\frac{\|k \rangle \langle l\| -\|l \rangle \langle k\| }{\sqrt{2}i}\,\, \left( k <l \right). \end{aligned}$$ Here $ \|k \rangle $ refers to a Fock state of number $k$. Note that each of $\lambda_k$ and $\lambda_{kl}^{\pm}$ represents a complete projective measurement individually. That is, $\lambda_k$ represents a two-outcome projective measurement, assigning $+1$ if the tested state is detected in $\|k\rangle$ and $0$ otherwise. On the other hand, $\lambda_{kl}^{\pm}$ represents a three-outcome projective measurement, assigning $\pm1$ if detected in the two eigenstates of $\lambda_{kl}$ and 0 otherwise. These observables satisfy the orthogonal relations $ \operatorname{Tr}\left( A_i^{(n)} A_j^{(n)} \right) =\delta_{ij}$ and the sum of variances must satisfy the uncertainty relation, $$\label{LUR1} \sum_j \delta^2\left( A_j^{(n)} \right) \geq \left(n-1 \right) \langle {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n \rangle,$$ where $\delta^2\left(A_j^{(n)}\right)= \langle \left(A_j^{(n)}\right)^2 \rangle-\langle A_j^{(n)} \rangle^2$ represents each variance and $ {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n = \sum_{k=0}^{n-1} \|k \rangle \langle k \| $ the projection to the Hilbert space of truncated $n$-levels. The proof of Lemma is given in Supplementary Information.\ \ Now consider an orthogonal $n^2 \times n^2$ matrix $ O_n $ in the truncated space, satisfying $ O_n^T O_n= O_n O^T_n = {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n$. Then the set of observables $ \left\{ \tilde{A}_j^{(n)} \right\}$ under the transformation $\tilde{A}_j^{(n)} = \sum_l O_{jl} A_l^{(n)}$ also satisfies the uncertainty relation in equation (\[LUR1\]) since $ \sum_{j} \left( \tilde{A}_j^{(n)} \right)^2 = \sum_{j,l,l'} O^T_{lj}O_{jl'} A_l^{(n)}A_{l'}^{(n)}=\sum_l \left(A_l^{(n)}\right)^2 =n {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n$ and $ \sum_j \langle \tilde{A}_j^{(n)} \rangle^2 = \sum_{j,l,l'} O^T_{lj}O_{jl'}\langle A_l^{(n)} \rangle\langle A_{l'}^{(n)} \rangle = \sum_l \langle A_l^{(n)} \rangle^2 $. This invariance property will be used later.\ \ We now obtain a non-steering condition based on these orthogonal observables.\ \ [Theorem]{}: If a two-mode quantum state $\rho_{AB}$ is non-steerable from B to A, it must satisfy the inequality $$\label{LUR-steer} \sum_j \delta^2 \left( A_j^{(n)} \otimes {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}+ g {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}\otimes B_j^{(n')} \right) \geq \left(n-1 \right)\langle {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n^{A} \rangle,$$ for any real $g$, where the observables $ \left\{ A_j^{(n)} \right\} $ satisfy the uncertainty relation in Eq. (\[LUR1\]). Its proof is given in Supplementary Information.\ \ We next introduce a useful criterion originating from the inequality (\[LUR-steer\]) that can be readily computable.\ \ [Proposition]{}: If a two-mode state $ \rho_{AB}$ is non-steerable from $B$ to $A$, the correlation matrix $ C_{nn'}^{TLOOs}$ with elements $\left( C_{nn'}^{TLOOs} \right)_{ij}\equiv\langle A_i^{(n)} \otimes B_j^{(n')} \rangle-\langle A_i^{(n)} \rangle\langle B_j^{(n')} \rangle$ constructed with $n$- and $n'$-level truncated local orthogonal observables (TLOOs) must satisfy ($ \\|\,\cdot\\|_{tr}$: trace norm) $$\begin{aligned} \label{steering-tr} &&\\| C_{nn'}^{TLOOs} \\|_{tr} \nonumber\\ &&\leq \sqrt{ \left( \langle {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n^{A} \rangle -\sum_{j=1}^{n} \langle A_j^{(n)} \rangle^2 \right) \left( n' \langle {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_{n'}^B \rangle - \sum_{j=1}^{n'} \langle B_j^{(n')} \rangle^2 \right)}.\nonumber\\\end{aligned}$$ The proof of Proposition in Supplementary Information clearly shows that if a given state violates the inequality (\[steering-tr\]), it is steerable from B to A, and also that there exist a set of TLOOs that violates the inequality (\[LUR-steer\]) as well. We give some details on how to calculate the expectation values of TLOOs for a given state in Supplementary Information. ![Detection of steerability for a lossy Gaussian state based on the criterion in equation
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4815, 403, 417, 9295, 494, 15, 50276, 510, 10272, 273, 4815, 310, 1512, 8244, 3033, 281, 253, 2589, 273, 253, 2332, 281, 9659, 1273, 29985, 432, 253, 16939, 10955, 15, 50276, 1231, 3103, 12009, 253, 3482, 434, 4831, 323, 3081, 4815, 15, 535, 187, 1706, 187, 510, 3482, 671, 3916, 326, 703, 310, 7429, 281, 3081 ]	if it failed to comply with an applicable government statute or regulation. Id. Sec. 403(2). We assume that a product's failure to conform to the state of the art at the time of its sale is evidence of a defect, although that failure does not rise to a presumption. 18 These provisions set the stage for proof of the state of the art at the time of the sale of the product. In order to prove the state of the art, evidence of what other manufactures are doing is clearly relevant and admissible. Section 13-21-404, the statute at issue in this case, is not addressed to subsequent remedial measures by the manufacturer, but appears instead to cover scientific advancements made by anyone where such advancements were "discovered" subsequent to the time the defendant manufacturer sold the product in issue. Read together with section 13-21-403, the Colorado legislature was merely establishing in section 13-21-404 that subsequent scientific advancements are the flip side of the state of the art at the time of sale, i.e., that if the design change or warning technique was not scientifically known at the time of the sale and therefore not state of the art, it is simply not relevant to whether the product was defective. On the other hand, a subsequent scientific advancement is relevant to a manufacturer's duty to warn its previous purchasers, and therefore it is admissible to show such a duty. 19 Subsequent to the enactment of section 13-21-401 to 405, the Colorado legislature adopted its own identical version of Fed.R.Evid. 407. The Committee Comment states: "The phrase 'culpable conduct' is not deemed to include proof of liability in a 'strict liability' case based on defect, where the subsequent measures are properly admitted as evidence of the original defect. But see Sec. 13-21-404, C.R.S. 1973 (1978 Supp.)." Colorado Rule of Evidence 407, Vol. 7B Colo.Rev.Stat. (1982 Supp.) (emphasis added). Following the two earlier Colorado court decisions in Roberts v. May, 41 Colo.App. 82, 583 P.2d 305 (1978), and Good v. A.B. Chance Co., 39 Colo.App. 70, 565 P.2d 217 (1977), the Colorado legislature chose to make Rule 407 inapplicable to products liability cases. The Comment establishes that the legislature contemplated the admission of some kinds of subsequent remedial measures in products liability cases, the exception being the limitation set out in section 13-21-404. 20 We read section 13-21-404 the way we do in part because it makes no sense that evidence of subsequent remedial measures would be admissible in Colorado to show feasibility in negligence cases, but not admissible in products liability cases under defendant's reading of the section. In our view, feasibility of alternative design is one way of establishing state of the art, proof of which is definitely contemplated by section 13-21-403. 21 Reading section 13-21-404 the way we do, we are of the view that the burden is upon the person who wants to muffle evidence to show that the advancement in question was "discovered" subsequent to the time of the sale. Here defendant argued that the section precluded admission of any subsequent remedial measure except to show duty to warn. Although defendant might have been able to make a case for application of section 13-21-404 to the valve design change that Heil patented, defendant failed to distinguish between that "subsequent discovery" and changes in the length of the shroud or use of a safety brace that were probably within the state of the art in 1972. Since defendant failed to show grounds for the application of the Colorado statute, and since 407 does not exclude this evidence, it is admissible under Rule 402. 22 The Decedent's Possession of Drug Paraphernalia 23 In the course of their investigation, the police inventoried Mr. Meller's personal possessions found at the scene of the accident. They discovered two hashish pipes containing marijuana residue in his rucksack. However, they found no evidence that he had used marijuana immediately before the accident. 24 Heil sought to admit the hashish pipes at trial, claiming that they were probative of the decedent's life expectancy and that they impeached prior testimony by the plaintiff. The district court excluded the pipes, concluding that their probative value was substantially outweighed by the danger of unfair prejudice. See Fed.R.Evid. 403. We agree. Heil provided no medical foundation for its claim that Mr. Meller's life expectancy was diminished by drug use. Furthermore, the pipes were of questionable value as impeachment material. Indeed, the testimony Heil sought to impeach involved statements of questionable admissibility that Heil itself had elicited.9 It appears that Heil sought to introduce the hashish pipes for the specific purpose of arousing juror sentiment against the decedent. The district court clearly acted properly in excluding this evidence. Product Misuse 25 At the close of trial, Heil requested that the jury receive an instruction explaining the defense theory of product misuse. The court denied the request and concluded that the elements of the defense were absent in this case. The court did instruct the jury on the defense theory of assumption of risk; however, Heil argues that it was entitled to an instruction on product misuse as well. 26 Heil's product misuse defense is, in essence, that Mr. Meller caused his own death by choosing to position himself under the dump bed while greasing the truck chassis. As Heil recognizes, the product-misuse defense requires a showing that injury was caused by the dangerous misuse of a product in a manner that could not reasonably have been anticipated by the manufacturer. E.g., Kinard v. Coats Co., 37 Colo.App. 555, 553 P.2d 835, 837 (1976). The defense protects the manufacturer who, in designing a product for a particular use, incorporates safety measures consonant with the full range of foreseeable applications. It recognizes that neither fairness nor the goals of enterprise liability are furthered by assessing liability for injuries arising out of unforeseeable applications of the product. See generally W. Prosser, Torts 641-82 (4th Ed.1971). 27 Viewing the defense in this light, it would be a misapplication of language and law to describe Mr. Meller's accident as a result of product misuse. Mr. Meller was performing routine maintenance on the dump truck. To perform the maintenance, he had to work in close proximity to the dump bed assembly. Heil offered no substantial evidence that it could not reasonably foresee Mr. Meller's contact with a part of the dump bed assembly. Indeed, the record contains abundant evidence that Heil should have anticipated the likelihood that a person might place himself between the chassis and the dump bed and thereby encounter the obvious dangers associated with the trip cable. The court wisely declined to exhibit before the jury a defense theory that was unclothed by supporting facts. See Smith v. Mill Creek Court, Inc., 457 F.2d 589, 592 (10th Cir.1972); Radio Corp. of America v. KYFM, Inc., 424 F.2d 14, 19 (10th Cir.1970). Given the evidence adduced at trial, the court acted within its authority in denying the request for an instruction on product misuse. The district court properly distinguished the defense of assumption of risk, a defense that the jury rejected. 28 Sufficiency of the Evidence to Support the Verdict 29 The jury awarded the plaintiff $400,000 in damages (prior to addition of interest and costs), which represented Mr. Meller's discounted future earnings. Heil claims that this award is excessive, citing "an extremely unstable and irregular work background." Principal Brief for Appellant at 43. 30 At trial, the plaintiff's expert witness, an economist at Colorado State University, testified that the present value of the decedent's future earnings was $580,300.00. Heil had ample opportunity to rebut this testimony and, indeed, argued vigorously to the jury that the estimate was excessive. It appears that the jury, in exercising its duties as a finder of fact, gave substantial credence to the expert testimony. We conclude that the verdict is consistent with the evidence presented and represents a reasonable award of damages. 31 The Bill of Costs and Interest on the Judgment 32 The district court entered a judgment against Heil for $431,024.13 and assessed Heil with the costs of trial. The plaintiff cross-appeals from the judgment, claiming that the court erred in its calculation of the bill of costs and interest on the verdict. 33 The plaintiff claims that the court erred in excluding certain deposition and expert witness fees in the bill of costs. The plaintiff acknowledges that the award of costs is within the trial court's discretion. See True Temper Corp. v. CF & I Steel Corp., 601 F.2d 495, 509 (10th Cir.1979). We might, on occasion, question a court's decision to award no costs to a prevailing party. See id. We will defer broadly, however, to a district court's determination that certain elements of the bill of costs are not recoverable. The calculation of costs is too closely bound to the conduct of the trial to permit second guessing from the appellate bench. We therefore reject the plaintiff's demand for additional costs. 34 The plaintiff also claims that she is entitled to additional
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" I brought your pillow." " Thank you." " Is it hot?" " Yeah, a little." " I'm so happy to see you." " Me, too." "I brought your toothbrush and your phone." " The charger?" " Shoot, I forgot." "It's OK." "So how's your foot?" "It's really swollen." "The nurse said it's normal." "The doctor is coming." "Can you get some crutches?" "We'll walk around." "Good idea." "OK." "See you." "Where are we?" "Luxembourg." "Why'd you leave the highway?" "To fill up." "There's a gas station." " Shit!" "It's closed." " Yes." "We went 10 miles out of our way, and it's closed." "Should I even bother asking if you want me to drive?" "Millions of women drive." "That's the problem." "Still macho, I see." "Should we stop to eat?" "No." "Give me a sandwich." "Thanks." "It's good." "So what's the problem with the insurance?" "It's easy, no one wants to cover the accident." "Not Global, not the supplemental, or the mutual fund." "Because he was abroad over 3 months." "And the snow card?" "It even covers accidents off the slopes." "Guess what, he didn't have one." "That's just great." "Is he dumb?" "Yes..." "Kids think accidents only happen to other people." "OK, but?" "his employer should cover it." "No." "His contract ended 2 days ago." "Well, bravo!" "Water, please." "Thanks." "You think he'll be able to ski?" "I hope." "When he was 12 he said, "I like white, I like snow." ""I'll be a ski instructor."" "That's from you." "I know." " Do you regret it?" " No, he loves what he does." "But I'd worry less if he were a chess master." "OK." "Tell him his mother called." "Thanks." "I don't believe it." "He just had surgery and he's out with friends!" "Your son is insane." "Where does our son get that?" "From me, of course." "That means he can't be too bad." "Hand me some water, please." "Didn't Carroz d'Araches have any rooms?" "I called 3 hotels, everyone's full." "It's the seasonal ski instructor competition." "In Flaine, Pierre et Vacances only does weekly rentals." "I'm a little old to sleep at a youth hostel." "Jack's boss was nice enough to give us a room." "One room?" "Yes." "It's full there, too." "It's for kids, they probably have bunk beds." "What!" "We'll feel young again!" "Especially you." "Ridiculous!" "So, feeling restless?" "I came by and you were out." "I'm not used to sitting around." "Alright." "Let's see." "Does it hurt a lot?" "I'm taking painkillers." "It looks good." "Here are the X-rays." "It's all explained on the file." "Give this to your doctor in Belgium." "Okay." "Good news, you're getting out tomorrow." "Good luck, don't do anything crazy." "Don't walk on it for 4 weeks." "Your fracture needs time to heal." " Thanks, Doctor." " Have a good day." "You're lucky." "I need both arms in the kitchen." "I don't know where to go before I can work again." "And my family is in Algeria." " Where is the old man?" " The ICU." "He couldn't breathe." "Poor old man." "Here, man." "Good luck." " It'll be ok." " Yeah, like always." "I'm locked in!" "Hello?" "I'm locked in!" "Shit!" "No!" "I'm locked in the bathroom." "No one can hear." "Apparently neither can you." " Hello." " The men's room is there." "I know, but?" "I'm waiting for my wife." "Something's wrong." "All the same." "The same story." "That way, pervert!" " What?" " You heard me!" "Leave, now!" "You're going to look now, or I'll get a manager." "We wasted a half-hour and I was called a pervert." "I thought you'd fainted." "It's so typical of you!" "Don't yell at me, I didn't know the door was broken!" "Frans, slow down." "I think there's cops." "Huh?" "Where?" "Behind us, I saw a siren." "I can't see it." "When Jack was little, with his babysitter..." "Locked in the bathroom, he couldn't open the door." "Poor baby." "Where was it?" "Charente-Maritime." "He was 3." "You told me, but I wasn't there." "You were gone a lot." "Well no, no." "I was gone a lot." "You think he missed me?" "At first, yes, definitely." "Just after you left, he said:" ""Daddy's going to build a house, we'll live together."" "It was simple for him." "Later on?" "I don't know." "That music's cool." "What is it?" "No, but it's not bad." "Did you tell your parents?" "I don't have any battery." "I'll call from Flaine." "Room 205, please." "Follow the green line to the end." "Take elevator A to the 2nd floor." "Then the doors to the right to room 205." "What?" "Follow the green line." "OK?" "To the end." "You take the elevator." "Elevator A." "What's that?" "I didn't understand." "I'll take you to the elevator." " Ma'am." "Ma'am." " Sorry, I'll be back." "Not bad." "Recent construction, clean." "Surprising for France." "I hope the surgeon was good." "Hello." "We're here for Jack Vander." "What room number is he in?" "Mr. Vander left this afternoon." " What?" " He left at 4:00." " We'll send the bill to Belgium." " OK." "Thanks." "You're welcome." "What?" "Where is he?" "In Flaine." "Where else?" "It's ringing but no answer." "I'll try again." "Jack, how are you?" "Does it hurt?" "We were scared." " Thanks for the chocolate." " You're welcome." " Your foot is black and blue." " I call it Smurf." " Hey!" " Oh, hey." "And?" "You're back!" "How did you get out?" " Isn't it 5 days minimum?" " I was going crazy." " Hi, Jack." " Hi." "We're glad everything's OK." "Who was the surgeon?" "Dr... "think fables"." "Lafontaine." "He's the best." "Your parents are coming tonight." "They have a room." " Cool, thanks." " No problem." "You should lie down with your leg up, OK?" "Ask if you need anything." "Thanks, boss!" "OK." ""Your leg up", not something else up." "Shut up, Clement." " He could have called." " Maybe he has no battery." "He's not in the hinterlands though." "No." " I think he's in love." " Oh!" "How do you know that?" "He should have come home last week, but he said he wanted to ski." "I asked him if he met someone." "He said:" ""Yes, she's great, Mom."" "That Jack!" "Do you know who it is?" "No." "I just know her name's Alison." " Is she American?" " I don't know." "Why doesn't he ever tell me these things?" "You're both men." "It's weird." "Just concrete." "That's right." "A 1960 construction." "In harmony with the mountain." "It's a unique resort." "A great architect built it, Marcel Breuer." " Were you mad at me?" " Huh?" " Were you mad at me?" " Why?" "For leaving you." "No." "I was mad at myself." "For not trying." "It was a long time ago." "I like being alone now." "Shall we?" "Hi." "You're Jack's mom." "I can see right away." "We have the same expressions." "Do I look like his dad?" "Not as much." "Maybe the accent." "Alright." "Jack is in room 715, at the end." "You are just before his, room 700." "Call if you need anything." "I parked the car by the entrance." "Can I leave it?" "It's OK for an hour, then move it to the lot." "The cheaper one is Flaine forest." " Thank you, Ma'am." " Thanks!" "You know we love your son." "So do we." "Here it is." " Hi, come in." " Hi." "Hi, Mom." "Hi, Dad." "How was your trip?" "How are you, son?" "This is nice." "This is Al
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Ele e seus colaboradores, como tantos liberais classe superior euros, então e agora, foi cego pelas ilusões sociais utópicas encarnado no cristianismo e na democracia, que resultam da 295 psicologia da aptidão inclusiva de intuições coalizões e altruísmo recíproco, que foi eugênico e adaptativo no EEE (ambiente de adaptação evolutiva-i. e., de ca. 50.000 a vários milhões de anos atrás), mas é fatalmente disgênico e maladaptável nos tempos modernos. Note a grande ironia da citação dele que começa o livro, que mostra que mesmo os mais brilhantes são vítimas de seus próprios limites, e não têm nenhuma compreensão da biologia humana, psicologia ou ecologia. Nunca passou pela sua cabeça que o mundo se tornaria horrivelmente superpovoado e que os africanos cresceriam para se tornar um problema social gigante, em casa e para si e para o mundo como a África se expande para mais de 3.000.000.000. Da mesma forma, apesar do desastre agora claro, parece não cruzar Obama que o diverso em casa e no exterior vai destruir a América eo mundo, embora qualquer brilhante de dez anos de idade pode vê-lo. O Presidente Truman poderia ter deixado McArthur usar a bomba atômica para acabar com a guerra coreana, destruir o comunismo e evitar o horror contínuo da China executado por 25 sociopatas (o Politburo) ou realmente apenas sete sociopatas (o Comitê ereto de Politburo) ou talvez realmente apenas um sociopata (Xi Jinping). Johnson poderia ter feito do mesmo modo no Vietnã, Bush no Iraque e Obama no Afeganistão, Síria e Líbia. China e provavelmente muitos países do 3o mundo teriam usado armas nucleares se as situações fossem invertidas. Uma vez que um país muçulmano radical recebe a bomba, um ataque preventivo por eles ou sobre eles provavelmente ocorrerá,, e isso é provável por 2100 e perto de certo por 2200. Se Gaddafi tivesse conseguido os seus esforços para conseguir a bomba, seria muito provável que tivesse acontecido. Os EUA poderiam ter forçado o Japão, a China e a Coréia, o Iraque e a Líbia e todos os países da Europa (e todo o mundo para esse assunto) a pagar pelos custos dos nossos esforços militares em todas as guerras recentes, e entre guerras, em vez de assumir a maior parte do custo e, em seguida, ajudá-los a assumir a maior parte da fabricação da América. É claro que essas decisões, críticas à sobrevivência do país, foram feitas por um punhado de políticos sem consultar os eleitores. Os Kennedy foram uma parte importante da mudança das leis de imigração em meados dos anos 60, então eles têm que contar como traidores e grandes inimigos da América em um par com Obama, G. W Bush os Clintons. Poderíamos ter seguido os fundamentos universais da indústria dos EUA e se recusou a assinar o GATT, que deu acesso livre a todas as nossas patentes anos antes de serem concedidos, embora, naturalmente, os chineses agora hackear e roubar tudo com impunidade de qualquer maneira. Eisenhower poderia ter deixado o Reino Unido manter a posse do canal de Suez, em vez de chantageá-los para sair do Egito, e sobre e sobre. Alguns podem estar interessados em algumas estatísticas para dar uma idéia de onde estamos atualmente na estrada para o inferno. Veja as tabelas no início. Nos EUA, a 296 população de hispânicos vai inchar de cerca de 55 milhões em 2016 (ou tanto quanto 80 milhões se você aceitar algumas estimativas de ilegalidades 25 milhões-é uma marca de quão longe o governo deixou as coisas vão que nós realmente não sabemos) para talvez 140 milhões meio século e 200 milhões como entramos no século 22 , momento em que a população e.u. vai estar subindo passado 500 milhões, e a população mundial será de cerca de 11 bilhão, 3.000.000.000 de que acrescentou a partir de agora para então na África e 1.000.000.000 em Ásia (as estimativas oficiais da ONU no momento). Os hispânicos estão se reproduzindo tão rápido que os euros, agora uma maioria 63%, será uma minoria por meio século e cerca de 40% por 2100. A maior parte do aumento nos EUA a partir de agora será hispânicos, com os negros restantes, asiáticos e muçulmanos, e todo o aumento aqui e no mundo será 100% diverso. Cerca de 500.000 pessoas são naturalizadas anualmente e uma vez que são principalmente do mundo 3 e produzem crianças em cerca de duas vezes a taxa de euros, que irá adicionar talvez 2 milhões meio século e 5 milhões por 2100 para cada ano que continua. Para mostrar o quão rápido as coisas saíram do controle após o "sem impacto demográfico" TKO (técnico nocaute ou Ted Kennedy indignação, embora pudéssemos igualmente chamá-lo de ultraje LBJ, o ultraje Neomarxista, o ultraje liberal etc.) ato de imigração de 1965, há agora mais hispânicos na Califórnia do que há pessoas em 46 outros Estados. Em 1970 logo após o TKO, havia cerca de 4 milhões hispânicos e agora há mais de 55 milhões "legais" (ou seja, não é feito legal pelos eleitores, mas por um punhado de políticos e da Suprema Corte estúpida) e talvez 80 milhões contando ilegais. Nunca atravessa as mentes do bloco democrático-voto pobre diverso que aqueles que sofrerão de longe mais da "diversificação" dos Estados Unidos são eles mesmos. Os E.U. passou de 84 por cento branco, 11 por cento preto, 4 por cento hispânicos e 1 por cento asiáticos em 1965, para 62 por cento branco, 11 por cento preto, 18 por cento hispânicos e 6 por cento asiáticos agora, de acordo com um relatório recente do Pew. Por 2055, nenhum grupo é esperado para ter uma maioriaum cenário perfeito para o caos, mas você pode ver inúmeros da Academia (agora um paraíso para o estado financiado Neomarxisto terceiro mundo supremacismo) elogiando o multipartisanismo. Os asiáticos estão previstos para aumentar mais rápido do que qualquer grupo, dobrando a sua percentagem nas próximas décadas, mas pelo menos eles vão ter ido através de um procedimento de imigração mínima, exceto, naturalmente, para as famílias de bebê âncora (produzindo que agora é uma grande indústria como Os asiáticos voam aqui para dar à luz, embora sejam grandemente ultrapassada pelos hispânicos que só têm de atravessar a fronteira à noite). Naturalmente, os asiáticos são por e grande uma bênção para a América como eles são mais produtivos e menos problemas do que qualquer grupo, incluindo euros. O governo dos E.U. (sozinho dos países principais) empurra a "diversidade" mas nos países pelo mundo inteiro e durante todo a história as tentativas de sold
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1014, 1698, 5212, 1673, 310, 2424, 281, 1566, 253, 5553, 281, 17356, 14 ]	[@acc09].[]{data-label="Fig:IC443"}](IC443.eps "fig:") -0.0 true cm ![Same as Fig.\[Fig:M1\] but for middle-aged SNR W44. Upper panel: the blue dashed-dotted, purple dashed, and red solid lines correspond to $t=\rm 1 kry$, $\rm 5 kyr$, and $\rm 10 kry$, respectively, with $B=\rm 400 \mu G$. Lower panel: the dashed, dotted, and dashed-dotted lines correspond to $B=\rm 400 \mu G$, $\rm 200 \mu G$ and $\rm 100 \mu G$, respectively, at $t=\rm 10 kyr$, and the solid line represents the CBPL spectral fitting model. Also shown are observational data in radio by VLA (red points) [@cas07], and by Sardinia Radio Telescope (green triangles) [@lor18; @egr17], in $>0.1$ GeV gamma-rays by Fermi-LAT (cyan squares) [@ack13], and by AGILE (blue circulars) [@giu11].[]{data-label="Fig:W44"}](W44ED.eps "fig:") ![Same as Fig.\[Fig:M1\] but for middle-aged SNR W44. Upper panel: the blue dashed-dotted, purple dashed, and red solid lines correspond to $t=\rm 1 kry$, $\rm 5 kyr$, and $\rm 10 kry$, respectively, with $B=\rm 400 \mu G$. Lower panel: the dashed, dotted, and dashed-dotted lines correspond to $B=\rm 400 \mu G$, $\rm 200 \mu G$ and $\rm 100 \mu G$, respectively, at $t=\rm 10 kyr$, and the solid line represents the CBPL spectral fitting model. Also shown are observational data in radio by VLA (red points) [@cas07], and by Sardinia Radio Telescope (green triangles) [@lor18; @egr17], in $>0.1$ GeV gamma-rays by Fermi-LAT (cyan squares) [@ack13], and by AGILE (blue circulars) [@giu11].[]{data-label="Fig:W44"}](W44.eps "fig:") SNR IC 443 and W44 are two middle-aged ($\sim \rm 10kyr$) SNRs surrounded with dense molecular clouds (MCs) [@ack13; @car14; @tav10; @fan13; @uch10]. Since they are close (with distances of 1.5 kpc and 2.9 kpc for IC 443 and W44, respectively) and bright in gamma-ray energies, they are the best studied SNRs so far. @ack13 shows that the 4-year observations with Fermi-LAT on IC 443 and W44 reveal the characteristic “pion-decay bump" in the sub-GeV gamma-ray spectra, which tends to exclude a leptonic-only model for the GeV gamma-ray emission from IC 443 and W44. This provides an evidence of CR acceleration in SNRs. If the GeV emission is produced by hadronic interactions, there should be accompanying SEPs which produce synchrotron radiation in the postshock magnetic field. Again we use CBPL spectral model to fit the gamma-ray data of SNRs IC 443 and W44, and then the best fitting parameters are shown in Tab.\[Tab:spectral fitting\]. The results of derived SEPs’ and synchrotron radiation spectra are shown in Figs.\[Fig:IC443\] and \[Fig:W44\] for IC 443 and W44, respectively. We see that the synchrotron flux increases with the magnetic field. Since the predicted flux cannot exceed the observed radio emission, we can give upper limits to the magnetic field, $B\la350\mu$G and $\la400\mu$G for IC 443 and W44, respectively. However, the predicted flux and spectral index are both well consistent with observations, which may implies that the radio emission is mainly produced by the synchrotron radiation of the SEPs. In fact, the observed radio spectral index, if explained by synchrotron radiation, needs a power-law distributed electron population with a spectral index $p=1.75$, which is harder than DSA predicted index $p\approx2$. These facts suggest that the radio emission from IC 443 and W44 is more naturally explained by SEP radiation with magnetic fields $B\simeq350\mu$G and $\simeq400\mu$G, respectively. Discussion ========== In the hadronic model for RX J1713.7-3946, a spectral bump in $10^{-5}-10^{-2}$eV may show up if the magnetic field is the order of mG (Fig.\[Fig:M1\]). Observations in microwave to far-infrared bands are encouraged to confirm if it is there, and test the origin of the gamma-rays. However, an upper limit $B\la2$ mG is constrained in this model by the observed radio flux. @hua08 have obtained comparable result of the magnetic field by carrying out a detailed Monte Carlo particle collision calculation of the SEP production. We here directly use the observed gamma-ray spectrum to derive SEP spectrum analytically, avoiding the complicated numerical calculation of the hadronic interactions. The synchrotron spectrum from radio to X-ray bands from SNRs can be used to constrain the magnetic field $B$ in the SNR shocks, as discussed in [@wangli14]. In the spectrum there is a spectral break $\nu_{\rm cool}$ corresponding to the electrons with a radiative cooling time equal to the SNR age, $h\nu_{\rm cool}\approx3(B/100\unit{\mu G})^{-3}(t/1\unit{kyr})^{-2}$eV, only function of $B$ and $t$ [e.g., @kw08]. If the injected electrons’ index is $p$, then the synchrotron spectral slope changes from $F_\nu\propto\nu^{-(p-1)/2}$ below $\nu_{\rm cool}$ to $F_\nu\propto\nu^{-p/2}$ above $\nu_{\rm cool}$. Given the observed radio flux (below $\nu_{\rm cool}$), and the X-ray flux (maybe above $\nu_{\rm cool}$, we can constrain $\nu_{\rm cool}$ and then $B$. For $p\sim1.8$ [@hes16] derives $B\sim70\mu$G in RX J1713.7-3946. If $p\ga2$ as expected by DSA theory, $\nu_{\rm cool}$ is larger and $B$ becomes smaller, $\sim10$’s $\mu$G. Small $B$ will lead to enhancement of the inverse-Compton (IC) radiation, and favor leptonic model for the gamma-rays from RX J1713.7-3946. If the bulk of gamma-rays from RX J1713.7-3946 is mainly produced by leptonic process, the possible hadronic component should be below the observed flux. A promising flux of pionic gamma-rays is assumed in Fig.\[Fig:M2\]. The corresponding SEP radiation may show up at $\ga100$keV. For synchrotron radiation at 100 keV, the corresponding pionic gamma-ray energy should be $\sim1$ PeV provided the magnetic field strength $B \sim \rm 10 \mu G$ [@wan16]. So a detection of hard X-rays at $100$ keV may provide the evidence of existence of PeV gamma-rays and hence CRs beyond the spectral knee from the SNR. However, a deep observation in the level of $\sim10^{-13}\rm erg\,cm^{-2}s^{-1}$ is required for the future hard X-ray telescopes. As for IC 443 and W44, the derived SEP radiation can well match the radio data with $B=350\mu$G and $400\mu$G, respectively (Figs \[Fig:IC443\] and \[Fig:W44\]). Besides the “pion-decay bump", these results further support the hadronic origin of gamma-rays. The required relatively large magnetic field, $B\sim100$’s $\mu$G, is consistent with the hadronic model but disfavors leptonic one [e.g., @car14]. Moreover, the large $B$ can be well explained by the large density of the surrounding MCs, since the postshock magnetic field is $B\sim\sqrt{8\pi\epsilon_Bnm_pu_s^2}$ (with $\epsilon_B$ being the energy fraction of the postshock internal energy carried by magnetic field). For example, for W44 the CO data obtained from the NANTEN2 telescope imply a dense medium with $n \sim 250 -300 \rm cm^{-3}$ [@car14], then the postshock magnetic field is $B\sim0.4(\epsilon_B/10^{-1})^{1/2}(n/200\unit{cm^{-3}})^{1/2}(u_s/300\unit{km\,s^{-1}})$mG, consistent with the requirement for SEP radiation to account for the radio emission. The measurement of the postshock magnetic field is important for the study of the collisionless shock physics. In any case, by requiring the SEP synchrotron radiation not exceeding the observed radio-to-X-ray flux we can give an upper limit of the magnetic field. This is simply true if the gamma-rays are hadronic origin. If, however, the gamma-rays are leptonic origin, an even low magnetic field is required to model the radio to gamma-
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2581, 13631, 449, 187, 187, 2512, 369, 10837, 323, 247, 1643, 9506, 1223 ]	's photograph in this casual way." "Then it won't perhaps be tactful to give Lady Cantelupe a receipt for it." And Appleby picked up the photograph of Marian Page. "But you can be a witness that I'm making off with it. And now I must go and make some inquiries elsewhere." Diamond seemed surprised that their interview was over. "Well," he said – and his voice was ever so slightly jaunty – "I hope you've learned something here for a start." "As a matter of fact I have. Quite a lot. Good morning." Late that evening, as the two men dined together, the Minister listened moodily to Appleby's account of his investigations during the day. "And the girl – this Marian Page?" he asked. "She has certainly disappeared. The lab got a telephone message on the Monday, saying that she was unwell and would be away some days. And her landlady got a similar message that afternoon, saying that Miss Page had heard that her mother was dangerously ill, and had gone at once to join her in the country. I've checked that the message was false. Miss Page's mother is quite well." "People seem to have been a bit casual about the girl. Do you think it sounds like her running away with Cantelupe? I don't." Appleby shook his head. "I don't believe it for a moment. And I don't believe that he shoved her, or any girl, into a cupboard. It's not the way that a man like Cantelupe makes an ass of himself. And what is suggested to me by the manner in which he left his house is something quite different." "Different?" The Minister waited for a moment. And when Appleby said nothing he added: "But there was that photograph." "There was indeed. It told me quite a lot. For one thing, I recognised it. I'd seen the girl – and with Cantelupe." "Good lord!" "It was about a month ago. I didn't recognise Cantelupe at the time, but I've checked up on my memory since. It was in a rather smart restaurant to which I'd taken my wife. Cantelupe was giving the girl dinner." "I see. And what was she like?" Appleby drained his tankard. "She was all right." "You mean–?" "It was a clear case, on its own high level, of the boss having infatuated himself with a girl about the place. She was handling it as well as she could. I expect she liked her job rather more than she liked him. A capable girl of strong character, I'd say." The Minister considered. "That would explain the photograph, and its decidedly temperate inscription." "Ah – the inscription. That introduces something else. In fact, the villain." "The villain, my dear Appleby?" "Just that. In tragic life, God wot, no villain need be. But this isn't tragic life, Minister – or if it is, it's criminal investigation as well. That photograph, you know, was leaning against a mirror. When I took it up, I saw the reflection of the back. It was blank. But Diamond realised he had made a slip in claiming to be able to identify the thing, and when I was examining the cupboard, he supplied that neat pencilled script himself." "Well, well!" The Minister had to make some effort to take this in his stride. "Would you say, then, that there was some intrigue between Diamond and the girl?" Appleby shook his head impatiently. "No. Consider the sequence of events. Cantelupe, who is impressionable in ways that his wife has learned to discount, starts up this middle-aged man's passion for Miss Page. He turns worried and nervous – which is a normal reaction to such a situation. On Monday Miss Page vanishes, to the accompaniment of those bogus telephone messages. On Tuesday morning Cantelupe goes out and makes a mysterious purchase. That afternoon there is the even more mysterious incident reported by Butt. Cantelupe's worry then turns to desperation, and on Thursday he disappears too. And you remember how he disappears?" The Minister nodded. "He walks out of his house, and straight past his own waiting car and chauffeur." "Precisely. It's not how a man in Cantelupe's position goes off for a lark – or even upon some serious resolution to make a complete break with his whole past life. It bears quite another character – and one, I suppose, that is sufficiently obvious." "Nervous breakdown?" "Just that. Or what they call, technically, hysterical fugue. Complete loss of memory, and disappearance into the blue." The Minister considered for a moment. "When a chap goes right round the bend in that way, isn't he pretty quickly picked up?" "Not always. Sometimes he behaves with a sort of unconscious cunning that defeats even an active hunt for days or weeks. Thanks to Lady Cantelupe's delay – and the obscure and sinister role of Diamond – there's been no hunt for Cantelupe until today." "Oughtn't this Diamond fellow to be locked up – or at least be made to give some account of himself?" The Minister had a recurrence of his mildly sardonic manner. "It's generally regarded as the right line with villains." But Appleby shook his head. "If I'm right in the way I see this case," he said gravely, "then the last thing we want do is to alarm Charles Diamond." Every newspaper next morning carried the story of Lord Cantelupe's disappearance. He was described as having been missing for several days. Scotland Yard believed that he was suffering from loss of memory. Importance was attached to reports that a man answering to his description had been seen in Cambridge, behaving in a dazed manner that had attracted attention. Lord Cantelupe was a Cambridge graduate, and it was thought that he might have returned to familiar ground. The police were conducting an intensive search both in the city and the surrounding countryside. It was in tones of considerable impatience that the Minister spoke to Appleby on the telephone shortly after breakfast. For one thing, there had been some delay in getting him through. "Look here, Appleby, did that news have to break like that? And how did the papers get on to it?" "I put it out myself. You don't disapprove?" Over the wire, Appleby's voice sounded flat and tired. "My dear fellow, you're a pretty sound judge. And it's good that we've got that line on Cambridge. But need that have gone out? There may be less virtuously disposed people than ourselves after him, remember." "There certainly may. But I don't think there's any extra danger in what we've done." Appleby's voice paused. "I think, Minister, you'd better come round and see me." "I come round and see you?" The Minister was startled. "At New Scotland Yard?" "No, no. I'm in Cantelupe's library. They got you through to me here. I think you'll be – well, interested." "I'll take your word for that. Give me ten minutes." And the Minister slapped down the receiver. There were two uniformed inspectors in the book-lined room. The Minister gave them a nod and then turned at once to Appleby. "Well, here I am. What about that fellow Diamond? I'm still uneasy at his being loose. Where is he?" "Not in this house – where I think he's ceased taking his duties very seriously. I rather hope that he's in Cambridge by this time." The Minister stared. "You mean that's all rot?" "Certainly. No more than an attempt at a little diversionary action. We still haven't a notion about Cantelupe's whereabouts. All we've got is his overcoat." "And how on earth–" "On Thursday evening he dined by himself in the very restaurant in which my wife and I saw him entertaining Miss Page. The head waiter thought he looked queer. And when he left he forgot his coat. And in the pocket there was that." Appleby picked up from a table beside him a small cigar-box. "Inside which there was this." He opened the box. It contained a broad, flat spool of metal ribbon. "The sequence is clear. Cantelupe received this by post on Tuesday morning. He didn't, here at home, have the machine to play it back on–" "You mean it's for one of those tape-recorder affairs?" "Of course it is, Minister. And Cantelupe went out, then and there, and bought one. It was, in fact, the large parcel he was seen bringing into this room. It's standing just behind you." The Minister swung round. "And the fellow you were telling me about, who sounds as if he was out of Happy Families–" "Mr Butt the butler? Precisely. But what he heard through the door was not the voice of an actual woman, but the voice of a woman recorded on this." Appleby tapped the cigar-box once more and then handed it to one of his colleagues. "I think, Minister, you'll find what it has to say rather striking." There was silence for a few moments while
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3041, 13, 5093, 14, 19192, 6804, 14, 2327, 2570, 15, 187, 187, 6052, 610, 18953, 15, 9537, 15, 12259, 452, 5907, 281, 19153, 14, 1258, 412, 253, 2199, 434, 806, 767, 12475, 275, 13079, 273, 49625, 253, 41930, 45504, 665, 452, 5439, 7350, 670 ]	invention is useful with all types of memory chips, including DRAM, SRAM (Static Random Access Memory), EEPROM (Electrically Erased Programmable Read Only Memory), and FLASH, a fast EEPROM. A high priority is the progression of DRAM memories, which are currently being redesigned to go from monolithic 16 MEG units to 64 MEG units. In the current redesign of SRAM memory units, the effort is to go from 1 MEG to 4 MEG units. The field of logic devices, e.g., FPGAs, is presently limited by the need for greater density of available gates and transistors, in order to perform more complex tasks.According to my numbering system, I'm up to 125 finished strips, 100 of which have actually been posted. I have about 15 or so that are outside of that I did before that numbering system (some posted, some not), and probably another 30 strips that are written an waiting to be finished up. I have a tablet PC that these have all been drawn on, which makes it go way faster than ink on paper. The downside is I have no hard copies to sell. The upside is that I actually have the time to do the darn thing. I draw them in batches of 10, sketching them all, then inking them all, then shading them all. This assembly line method seems to be working out well. Not sure what the Southland comment is about. I'm still in the Seattle area and loving it. This cartoon is not that much of an exaggeration from reality! My stepdaughter is a nurse, and A LOT of her bedridden patients were this big. When it was necessary to turn the patients over into a different position, she had to summon a special hospital "lift team" to do the job. Remember that great cartoon "Triplets of Belleville" where the city was full of enormously fat people?The Antikythera Mechanism is a primitive ancient computer of sorts, that using gears only, could predict astronomical positions. It was found in 1900 AC in a shipwreck, near the greek island of Antikythera. It is dated back to 150-100 BC. When a date was entered via a crank (now lost), the mechanism calculated the position of the Sun, Moon, or other astronomical information such as the location of other planets. Since the purpose was to position astronomical bodies with respect to the celestial sphere, with reference to the observer's position on the surface of the Earth, the device was based on the geocentric model. Speaking of free time, Facebook staff has free time. There work space have legos,there staff is encouraged to doddle around with all the games and continue thinking all the time. They skate board and use bikes and all kinds transportation. They keep them busy so they will forget about leaving,they feed them at work. The Bomb sights in WW II that used gears for calculation of airspeed, groundspeed, windspeed, and bomb profile were called analog computers, so I suppose that would apply to any mechanical solution. Digital is the realm where any signal or measurement was converted to binary for processing through gates/memory. Analog with electricity example would be op amps which simulate springs, dashpots, and levers in real life. Well, is a divide by 3 circuit using flip-flops analog or digital? Why isn't a divide by 3.xx using gears and an escapement the same? It is the flip-flop that actually got me wondering about modern classifications vs. marketing glitz. For example, Wikipedia describes the first "digital" watch in about 1920's and the Pulsar watches as being digital. The first was done with gears and simply had a digital readout (an escapement mechanism can avoid the matter of in-between states). The Pulsar could be done with gears too. Quartz watches are admittedly much more accurate that spring-loaded clocks, for example and it is nescessary to build a digital circuit to harness the crystall's accuracy. Another matter is that digital circuits consume much less energy and suffer less from degradation and wear. On the downside, it can be very tricky to solve a problem with a digital construct. Think of how many multiplication algorithms exist for the binary algebra. On the analog realm of two gears, you have a set gear ratio and by turning the first gear x times, the other is turned automatically by {x times the ratio}. But at what cost, with what accuracy, in what time and untill when? One question though.... Does Lego actually have those parts as play toys. And I like to know what kinda software is used in the animation. Are they pretty powerful or expensive.. What can I use in my level of work. I like to draw my Engraver Machine before I buy the parts. What kinda software are used to animate/draw those kinda objects. Well, is a divide by 3 circuit using flip-flops analog or digital? Why isn't a divide by 3.xx using gears and an escapement the same? It is the flip-flop that actually got me wondering about modern classifications vs. marketing glitz. For example, Wikipedia describes the first "digital" watch in about 1920's and the Pulsar watches as being digital. The first was done with gears and simply had a digital readout (an escapement mechanism can avoid the matter of in-between states). The Pulsar could be done with gears too. John Click to expand... A "Digital" Display is different than operating in the digital realm. There are clocks that move pieces of wood around to shape numbers, much like a 7 segment display. Making digits through this method could possibly not involve digital electonics at all (though the example I am thinking of does use a uC). Digital systems are essentially systems that use electronic level based (typically binary, but multi-valued logic exists) arithmetic to provide output. Analog systems do not assign values to levels, the measured voltage or current has no discrete steps as digital does. One question though.... Does Lego actually have those parts as play toys. And I like to know what kinda software is used in the animation. Are they pretty powerful or expensive.. What can I use in my level of work. I like to draw my Engraver Machine before I buy the parts. What kinda software are used to animate/draw those kinda objects. Click to expand... Yes, all these parts, even the differential, are official LEGO parts. The olny exception are the printed paper gauges LEGOs are expensive toys, as a general rule, but they never break. You buy them for life. Except if you leave them to rot for 3 years in the mercy of the elements like a friend of mine did. Then yes, the plastic will become brittle and fail. There are a couple of LEGO design softwares. Some are free and supported by LEGO. It makes sense, since they tease you with all those extensive libraries and then you decide to actually buy the parts. However they support only LEGO parts and will be of little use for any other purposes. Last time I checked was 2 years ago, with a software named LEGO Digital Designer. It had some issues though with too many block conflicts in the 3D space.Libertarian White House hopeful Gary Johnson said Tuesday it’s been his stated position that legalizing marijuana will lead to less substance abuse overall. “I took the position I took business-wise to make the world a better place,” Mr. Johnson, the former New Mexico governor, said on CNN’s “New Day.” “On the medicinal side, marijuana products directly compete with legal prescription drugs that statistically kill 100,000 people a year,” he said. “And on the recreational side, I have always maintained that legalizing marijuana will lead to less overall substance abuse.” Mr. Johnson, who won about 1 percent of the popular vote as the Libertarian Party’s presidential nominee in 2012, said there is a “total disconnect between elected politicians and the public.” “Sixty percent of Americans now want to legalize marijuana,” he said. “But the campaign to legalize marijuana in Colorado was a campaign based on marijuana is safer than alcohol, and it is. It’s safer than everything else that’s out there, starting with alcohol.” The Libertarian Party will choose its presidential nominee later this month at a convention in Orlando. Sign up for Daily Newsletters Manage Newsletters Copyright © 2020 The Washington Times, LLC. Click here for reprint permission.Bourne developers will build hotel first In an overture to wary Bourne sewer commissioners, the team behind a proposed Buzzards Bay development has offered to build a "brand name" hotel before tackling a $55 million, seven-story mixed-use complex. Comment By C. Ryan Barber capecodtimes.com By C. Ryan Barber Posted Jul. 10, 2014 at 2:00 AM By C. Ryan Barber Posted Jul. 10, 2014 at 2:00 AM » Social News BUZZARDS BAY — In an overture to wary Bourne sewer commissioners, the team behind a proposed Buzzards Bay development has offered to build a "brand name" hotel before tackling a $55 million, seven-story mixed-use complex. Perry Ave. Corp. developers have offered to flip-flop the project's first two phases in hopes of accommodating the sewer commissioners who have raised concerns about
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4310, 281, 755, 2218, 13, 594, 703, 812, 1091, 281, 617, 2021, 937, 12829, 790, 753, 15, 187, 187, 510, 4310, 7205, 753, 703, 9047, 347, 9221, 413, 14 ]	Series events at TMS in 2009 and 2010, is working on a stretch of six consecutive top-five results at “The Great American Speedway!” “I look forward to Texas anytime,” said Bodine, 47, who posted his first Truck Series win at TMS in October 2004. “Even outside the trucks – in Nationwide and Cup cars – I’ve run really well here. Anytime you have success at a track you enjoy the whole experience. Makes it nice to go back when you’ve got a shot to win.” That was one of Bodine’s selling points to Brendan, who spent the last two seasons in Brendan Gaughan has found a nice, fast home at Germain Racing. (RacinToday/HHP photo by Erik J. Perel) the Nationwide Series at Rusty Wallace Racing with funding largely provided by the Gaughan family’s South Point Hotel & Casino in Las Vegas. That sponsorship is funding the debut of the No. 62 Big Red Tundra this weekend. “I’ve been trying to get Brendan and Mr. Gaughan to race for us for three or four years,” said Bodine, who has finished among the top-five in points in five consecutive NCWTS seasons. “He finally got tired of running 15th and 20th in Nationwide and decided he ought to take a look at it here. “Me and Brendan have been longtime friends anyway. He stood up as a groomsman at my wedding (to Janet Paczkowski) last year. Everybody likes Brendan. Can’t help but like Brendan. He’s a good driver and good people and that fits our program.” Bodine believes his attitude toward the tour’s intermediate tracks has factored into his success at TMS. “I enjoy ‘em. And even with the ‘cookie-cutter’ thing…they all still have their own characteristics,” said Bodine, who trails only Kyle Busch’s seven all-time wins (five Truck/two Nationwide) at TMS. “They‘re not all the same and that’s what I find challenging _ figuring out those challenges and how to make them work to my benefit. Our 1.5-mile program, it’s our strong suit. We’ve won there (TMS) enough that I understand what you need to do; it’s a matter of getting the truck to do it for me.” Beyond Goodyear Racing’s ever-evolving tires, Bodine credited Hillman Jr.’s remarkably consistent setups with being a difference-maker. “We’ve only changed small things in our setup,” said Bodine, who has logged 21 Truck Series wins with Germain Racing and 36 during his NASCAR career. “When you’ve got a book that strong, it’s a great reason to be a part of that team, for sure. And that’s one reason Brendan and Mr. Gaughan wanted to come here. We’re going to run up-front.” Bodine has endured his worst start since joining the Truck Series fulltime in 2005, but a third-place finish in the O’Reilly Auto Parts 250 at Kansas Speedway last Saturday suggests better times are ahead at TMS. Bodine’s six wins in Fort Worth include four of the past five June races. Bodine is ninth in points, 78 behind leader Johnny Sauter. Additionally, Germain Racing has won 13 races on intermediate, or 1.5-mile, layouts like Kansas Speedway and TMS. Bodine also is the co-leader – with Kyle Busch – in intermediate track wins with 12. “It’s about luck,” said Bodine, recapping his uneven 2011 season. “Our performance has been good, just no luck at all. You can’t have a knee-jerk reaction if you’ve finished 14th Todd Bodine has a teammate with his kind of racing blood. (RacinToday/HHP photo by Erik J. Perel) or worse in most of the races. There’s nothing we can really change. We just need some luck. Last week was a great start. Hopefully we can keep it going.” Like the Bodines, the Gaughans boast a long and proud racing history. “My dad – he’s 68 – raced for 30 years in the off-road stuff,” said Gaughan, who followed his father into the desert ranks. “We love racing and love that genre and it’s meant a great deal for our business. It’s in the blood, it’s in the business model and it fits into our customer base. Whether I was driving or not we still have racing built into the budget. We’ll always have something racing with the South Point banner on it.” Gaughan followed-up his four consecutive wins at TMS with a near-championship in 2003, when he went into the NCWTS season-finale at the 1.5-mile Homestead-Miami Speedway with the point lead. Unfortunately, a mid-race accident relegated him to fourth in the final standings. Gaughan graduated to a Sprint Cup Series ride in 2004 in the No. 77 Dodge fielded by Doug Bawell in partnership with Roger Penske. After finishing 28th in points as a Cup rookie with only one-top five, Gaughan returned to the Truck Series in ‘05. Recapturing that “magic” has become Job One. “Anybody that knows me knows this is what I want to do for a living,” said Gaughan, currently 10th in points and 87 behind leader Sauter after a seventh-place finish at Kansas Speedway. “I’ve got a great college education (Georgetown University) and own other businesses. This is what I want to do. My desire is here. That’s why I’m still working my tail off to do it. I’m not going to hang out and run in the back and say, ‘Hey, I’m here’ and use excuses. I want the best equipment to show that I can still win. And the Germans have got one of the top three (organizations) in the Truck Series. “We’ve had great trucks all year. It just seems that bad things happen to me when I’m up front. I got a truck in the top-five, I’ve got to watch for the sky falling on me. We’re hoping to get two top-10s in a row here; I’d be really happy.” To that end, Gaughan is working under a one-year contract with the organization headed by Bob Germain Jr. “It’s a handshake deal with the Hillmans, more of a hug with Hillman Sr.,” said Gaughan, a 36-year-old native of Los Angeles who began the season with eight career NCWTS wins. “It’s a real people relationship and it’s completely an open book. Hillman Jr. is the book I wanted. (Crew chief) Brian Berry, I’m happy with that. But we’re here to take whatever Hillman Jr. puts on Todd Bodine’s truck and run it.” Fittingly, Gaughan held the record for TMS victories until Bodine won his fifth race in 2009. Head-to-head in eight races beginning in 2005, Bodine has come out on top six times. “Texas is a race I’ve been looking forward to with this Germain Racing team,” Gaughan said. “Todd and I are good friends. The Texas thing with all the wins is a decent rivalry. I keep bragging I got four in a row. But I would love to have this come down to me and Todd, and have a shootout between us.”A Connecticut jury today heard a chilling 911 tape from a Bank of America employee who called police in 2007 when Jennifer Hawke-Petit, walked into the branch asking for $15,000 from her account so she could give it to the men who were holding her husband and children hostage. Haunting surveillance video was also shown of Jennifer Hawke-Petit leaving the bank and getting into a car with the man who, within hours, would rape and kill her. It was a grim start to the murder trial of Joshua Komisarjevsky, 31, who is charged with invading the Petit's home along with Steven Hayes. During the seven hour ordeal, the family was battered, sexually assaulted, and the wife and two daughters killed. The ony survivor of the July 23, 2007 attack was Dr. William Petit, who sat in the first row today. The voice of bank manager Mary Lyons filled the courtroom as the 911 tape was played. "We have a lady in our bank right now who says her husband and children are being held at their house," Lyons tells police. She testified that Hawke-Petit only had pictures of her daughters in her wallet instead of the required two forms of ID, but the bank teller gave her the money. She described Hawke-Petit as calm, despite the harrowing circumstances. The Second Petit Murder Trial Begins Grimly At one point she can seen leaning over the counter and whispering in an attempt to save her family. "To me, she was trying to get done what she was sent into the bank to get done, so she could return to her family," Lyons said. The bank manager said she watched as Hawke-
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(-53(sqrt(540)/sqrt(5) + 4 + -5))22. -5400sqrt(3) + 49050 Simplify (-1 + -5 + -3(sqrt(425) + -1) + 2 + sqrt(51)/sqrt(3) + -1sqrt(272))2. 36sqrt(17) + 5509 Simplify 6(sqrt(10)/(-1sqrt(5)) + 5) + 5 + sqrt(450) + 1 + 3. 9sqrt(2) + 39 Simplify 5(2 + (2 + sqrt(80) + (sqrt(5) - sqrt(35)/(sqrt(28)/sqrt(4) + sqrt(7))) - ((sqrt(50)1)/sqrt(10) + -5))). 35sqrt(5)/2 + 45 Simplify 1 + sqrt(3) + ((sqrt(3) + 2)-2)2 + sqrt(12)/(sqrt(4)-1) + 1 + -1 + 4 + -1. 16sqrt(3) + 32 Simplify (-5 + -5(((sqrt(108) + (sqrt(108) - (-5 + sqrt(108))))-4)2 + 4 + sqrt(108) + -3sqrt(108)))-6-2. -127980 - 56880sqrt(3) Simplify (-1 + 5(-4 + -1 + (sqrt(363) - (sqrt(363) + 0))-3)-3)*2. 5476 Simplify (((-2sqrt(198))/sqrt(9) + 2sqrt(22)-2)/(1sqrt(44) + (sqrt(77) + -1sqrt(77))/sqrt(7)))*2. 18 Simplify (-1-2-6(-2sqrt(190) - sqrt(190))-6)/(((sqrt(90) - (sqrt(90) + -2(1sqrt(90) + sqrt(90)))) + (-1sqrt(90) + sqrt(90))-5)-1). 18sqrt(19) Simplify -5((sqrt(171)-2-2 - (-1 + -1sqrt(171) + sqrt(171)))*2 + (((-3sqrt(1900) - sqrt(1900)) + sqrt(1900))5-2)*2). -8563685 - 120sqrt(19) Simplify ((-3 + sqrt(1152) + (2sqrt(1152) + 3 - sqrt(1152)) + 4)-1 + -4)*2-4. -18688 - 3072sqrt(2) Simplify ((-4(sqrt(12) + sqrt(12)2) + sqrt(12))6-1)/((sqrt(396) - (sqrt(396)-2 + sqrt(396)) - sqrt(44))/(-3(sqrt(22)/sqrt(2) + sqrt(11)))). -396sqrt(3)/5 Simplify ((sqrt(425) + 0)*2 + (sqrt(85)-3)/sqrt(5) + -4 + 5)5. -15sqrt(17) + 2130 Simplify 3(((sqrt(416)/sqrt(8))/sqrt(2))/(sqrt(2) - -1sqrt(2)-2)-4 + -3). -9 + 12sqrt(13) Simplify -6((4 + -1*sqThe scene near Askeaton on the Rathkeale road where the bodies of Julia Holmes and Tom Ruttle were located at 3am on Monday Burglars discovered the badly decomposed bodies of an on-the-run fraudster and her partner when they broke into a rural farmhouse. The thieves rang gardaí in a panic after finding the remains of Julia Holmes (63) and Thomas Ruttle (56) side-by-side on a bed. The grandmother had the notorious distinction of being investigated by police on both sides of the Atlantic. Two handwritten notes, dated March 14, were found on the kitchen table of the house near Askeaton, Co Limerick, the Irish Independent can reveal. They were apparently signed by both of the deceased. A gang of well-known criminals stumbled on the bodies while they were ransacking the property looking for valuables. They fled the scene but feared they would be blamed for a double murder and rang gardaí at around 3am yesterday. Post-mortem examinations last night were inconclusive, but gardaí believe this was either a murder-suicide or a suicide pact between the couple. The house where the gruesome discovery was made was the home of Mr Ruttle, who was a separated father of grown children. He was a part-time farmer and mechanic from the area. He was the registered owner of two weapons, a rifle and a double-barrelled shotgun. It is understood a rifle was found on the floor next to the bed. Ms Holmes, who is originally from Ballynahinch, Co Down, had more than 20 convictions and was being sought by the gardaí and the PSNI for fraud offences. In 2006 she was deported from the US after she was arrested in connection with a $500,000 (€440,000) property scam in Texas. Irish IndependentCoffee at the office Quality Flexibility For your house or office, we adapt our services to your various environments. Speed To answer your needs, your order will be delivered directly to you within 48 hours. Coffee and Jeff de Bruges Chocolate Café Liégeois and Jeff de Bruges are partnering for your daily little moments For every Nespresso® compatible capsule bought, get a small chocolate Offer available with a minimum purchase of 30 capsules They trust us Coffee Beans A coffee directly from Europe that is assured to be fresh and meet your highest desires. Café Liégeois Newsletter Receive a 15% discount on your next order and stay up to date with the coffee world and Café Liégeois events."This batch has only been curing three days." "You want to explain that to the boss?" "'Cause I'll lend you the phone." "I'm just saying, it'll be a pretty harsh smoke." "Courier's coming for his two bags full, and that's what he's going away with." "Yes, sir, yes, sir." "Two bags full." "All set." "Did you see that bike?" "I bet that dude gets laid a lot." "I got to get me a bike like that." "Because that's the difference between you and him." "It's the bike." "What was that?" "I don't know." "Where'd my cheese puffs go?" "Where's your piece?" "I left it in the can." "Here." "I used to be a bouncer." "Cover me." "Hey, little guy..." "Hello." "And we thought there was something badass in here." "Primeval New World Angry Birds Original Air Date November 19, 2012" "Look, all I'm saying is, that before you go through another anomaly, at least give me the chance to collect some more data." "I didn't exactly plan it last time, Toby." "It just kind of happened that way." "Yeah, but if that's going to keep happening, then..." "I need to get an up-close look at one of these babies, you know?" "I need to get detailed readings, and start figuring out what really makes these things tick." "I thought your specialty was much more theoretical." "Well, there's something to be said about empirical evidence." "All right, we'll see." "Okay, fine, yes, yes," "I just want to see an anomaly, live and in person." "Well, admitting it is the first step." "Wow, you're sure settling in." "And I brought presents." "Wildlife tasers." "I thought we should have something in our arsenal besides Mac's cannons." "What are these going to do against giant lizards?" "It was designed to drop a charging rhino." "Oh..." "Point taken." "Mm-hmm..." "What do we have?" "Crap." "That's the new west warehouse district, next to the old pier." "There's lots of traffic there." "Okay, check the scanners for any emergency calls, any sightings in the area." "We'll call you from the road." "And..?" "Meet us out there with Mac when he shows up." "Bring those zappers." "You got it." "Yes!" "Uh-oh, where are you going?" "We have a follow-up with Umigen this morning." "I need to push that back." "Please tell me it's not another dinosaur." "We don't know what it is yet." "Dylan, hey, you've filled in the app for employee
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359, 497, 7824, 562, 273, 253, 4657, 13, 309, 2183, 619, 2243, 309, 9829, 37073, 2168, 15, 1500, 2546, 619, 849, 309, 369, 5471, 15, 309, 753, 13, 346, 42, 1928, 4030, 2243, 449, 1500, 753, 1270, 15, 309, 452, 271, 2934, 15, 187, 187, 9301, 2181, 309, 871, 359, 403, 387, 253, 19802, 41117, 15, 1244, 611 ]	IUCN Water and Nature Initiative (WANI) is doing with IUCN Member, the University of the South Pacific, on Kadavu Island in Fiji. The Kadavu project works with local communities to help identify water catchment management challenges, and ways to overcome these which will result in better quantity and quality for water, both in streams and the coastal areas. The meeting took place in Koror, Palau, from 19-23 July 2010. The Pacific Islands Geoscience Commission (SOPAC) is the GEF Executing Agency for the Pacific IWRM Programme which is funded by both the GEF and the EU Water Facility IWRM Planning Programme.Campaigners who want better access at a train station has been recognised at a national awards ceremony for its hard work. The Chinley and Buxworth Transport Group scooped the Best New Group in the Railfuture organisation awards earlier in the month and also took home a commendation in the category Best Campaign. Paul Tattam from the group said: “These awards look at stations up and down the county and the fact we have won in one and been commended in another category is just fantastic and really reflects the hard work of everyone involved.” Railfuture’s annual Awards for Rail User Groups, which started in 2012, aim to recognise and reward local volunteers who come together and work tirelessly to improve their local railway - its stations and services - on behalf of their passengers, efforts which all-too-often would otherwise pass unheralded. Chinley and Buxworth Transport Group has been tackling the issue of access at the station as both platforms can only be reached by using two sets of steps. Paul said: “We want to make the train accessible for all, bet that parents with pushchairs, the disabled and those with bicycles and currently it isn’t. “bieng at the awards has raised our profile and is very good as it maintains interest in what we are doing and why. “I didn’t think we would win outright for our campaign and we lost out to a much bigger station in London but I really pleased with the special recognition.” Awards organiser Roger Blake said: “This new group has achieved a great deal in a short time. They still have a big challenge ahead of them, as small stations such as Chinley are fairly low down the pecking order when it comes to funding priorities, but it’s another example of where access improvements can reap huge benefits for existing passengers, and attract new rail users, this is why we supported the group.”Cardiac vagal tone: a physiological index of stress. Cardiac vagal tone is proposed as a novel index of stress and stress vulnerability in mammals. A model is described that emphasizes the role of the parasympathetic nervous system and particularly the vagus nerve in defining stress. The model details the importance of a branch of the vagus originating in the nucleus ambiguus. In mammals the nucleus ambiguus not only coordinates sucking, swallowing, and breathing, but it also regulates heart rate and vocalizations in response to stressors. In mammals it is possible, by quantifying the amplitude of respiratory sinus arrhythmia, to assess the tonic and phasic regulation of the vagal pathways originating in the nucleus ambiguus. Measurement of this component of vagal tone is proposed as a method to assess, on an individual basis, both stress and the vulnerability to stress.Niam Audio launches NaimUniti Things you might also like Naim Audio has announced the launch of the new "NaimUniti" an all-in-one audio player with an integrated amplifier, CD player, DAB/FM tuner, internet radio player, iPod and MP3 dock, digital to analogue converter, USB and network-stored music file player and network streamer. Offering a 10-input, 50-watt-per-channel integrated amplifier, users can hook up digital sources including games consoles, satellite TV recorders/receivers and DVD players to the audio player. Said to be easy to use, the system's front panel display is said to "ensure real ease of navigation", Naim says "just add a pair of speakers and it's ready to perform". The NaimUniti is available this month for £1995 - plus £95 for an n-link iPod connector, with Naim Audio's n-SAT satellite speakers angled as the "ideal match" priced at £770.Defining optimal therapy for muscle invasive bladder cancer. We defined an optimal curative strategy for muscle invasive bladder cancer and to determine how best to deliver curative therapy. We reviewed published reports from 1985 to 2006 dealing with the treatment of muscle invasive (stage T2-T4a) bladder cancer. We analyzed all cohort, phase II and randomized phase III studies providing level 1 to 3 evidence impacting survival. Cisplatin based chemotherapy combined with high quality radical cystectomy and complete pelvic lymph node dissection improves survival over that of cystectomy alone. Surgery quality is an important predictor of survival even in patients receiving chemotherapy. Neoadjuvant chemotherapy is favored over adjuvant chemotherapy because it is better tolerated and more patients are able to receive effective therapy before rather than after surgery. Neoadjuvant chemotherapy followed by radical cystectomy and complete pelvic lymph node dissection is the optimal curative strategy in most patients presenting with muscle invasive bladder cancer.Although the eighth annual Taste of Blaine at the National Sports Center Feb. 21 did not draw in as many people as it did last year, event organizers and restaurants were very happy with the new venue and how the event turned out....Read More The Coon Rapids Rotary Club invited all of its 2012 community grant recipients to the club’s weekly meeting where President Steve Rice handed out checks and gave the representative of each organization a chance to introduce themselves and their mission....Read MoreMy Name is Sarah MY NAME IS SARAH. I am a quilt designer and the sewcial director of Sarah's Sewcial Lounge. I also have a business called Down Right Charming. I sell my quilts mostly on etsy and I make pillowcases to donate to patients in the hospital in memory of my friend Kristen Kirton. I am a young adult living with Down syndrome. I hope you enjoy reading about my life journey. Monday, August 27, 2012 My Very Special Katie Weekend I had the greatest surprise this weekend. Do you remember when I was collecting coins in a jar for Katie? We were raising money in the store to help bring Katie home from Russia. Guess what? She came to see us this weekend. It was so exciting. Her whole family came all the way from Tennessee to meet me. Look at this. They brought me a shirt. We have a customer who is really going to like it when I wear this because she is from Tennessee too. At first Katie was a little shy. So I just sat in my chair and waited until she got used to me. First, she went to Katrina. She really liked her. Katrina is so nice. She is a nurse. We are so lucky she works with us on Saturdays. I think Katrina really liked Katie too. And then Katie went to my mom. My momma really liked that. They squeezed and hugged and I could tell my mom really loved Katie. Then she took her over in the corner and put a dress on her. We had been waiting for Katie to arrive to see if it would fit. It was made with fabric from our favorite designer Kate Spain. They share a name. Katie went over to the mirror to see herself. She loved the dress. And she loved looking at herself in the mirror. I don't think they had mirrors in the institution Katie lived in. She was so cute making faces at herself. Then we tried another dress on. She loved that one too. It fit perfectly. And then she came and sat in my lap. I melted. We just sat there for a long time. Katie was drawing. And I was holding her. And talking to her. We were having a good time. She liked my dog. We were talking about her being a smart little girl. She is talking a little bit. And she can follow directions. My mom told me she will learn really quick now that she is with her forever family. I am so happy for her. Katie and I started becoming friends. I don't think she knows that we both have Down syndrome. We started playing together. Katie loved drawing with this pencil set. I wished she lived closer to me. I would play with her all the time. I could not forget about Katie's brothers, Henry, Jack and David. They were so good waiting for us. So I gave them each a pillowcase I made. They have two dogs at home so we picked ones with dogs on them. Look at Jack. He is so silly. He put his pillow case on top of his head. I was so happy that Kim made all the plans to come see us. It was such a treat. Before they left, Flat Stanley had to pose with me and my sign. He gets to travel the world!!! On Sunday, I had to get up really early to go to the Apple store. We were signed up for the class. It turned out to be the wrong class. Darn. As we were walking out of the store, I told my mom I missed Katie already. She asked my how I was feeling. I said, "I feel fine mom." She said great. I have an idea. Next thing I know we are at the Cleveland Zoo. And K
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337, 15, 20, 5, 29352, 15, 380, 1263, 273, 8973, 17174, 3400, 2289, 281, 5113, 598, 281, 495, 7367, 273, 9777, 4577, 685, 253, 8004, 24802, 11505, 39398, 23317, 9448, 313, 9180, 1909, 582, 835, 954, 8973, 17174, 403, 1869, 281, 452, 23923, 15, 8973, 17174, 403, 671, 253, 954, 12482, 5113 ]	store and the fact that it tags absolutely everything in its collection, including vintage audio recordings, videos, photos and other media, Schulz explains. The actual content -- which is seldom accessed -- is ideally kept offline and on tape, Schulz says, with perhaps a thumbnail or low-resolution copy on disk. Today, the library holds around 500 million objects per database, but Youkel expects that number to grow to as many as 5 billion. To prepare, Youkel's team has started rethinking the library's namespace system. "We're looking at new file systems that can handle that many objects," he says. Gene Ruth, a storage analyst at Gartner, says that scaling up and out correctly is critical. When a data store grows beyond 10PB, the time and expense of backing up and otherwise handling that much data go quickly skyward. One approach, he says, is to have infrastructure in a primary location that handles most of the data and another facility for secondary, long-term archival storage. 2. Amazon.com E-commerce giant Amazon.com is quickly becoming one of the largest holders of data in the world, with around 450 billion objects stored in its cloud for its customers' and its own storage needs. Alyssa Henry, vice president of storage services at Amazon Web Services, says that translates into about 1,500 objects for every person in the U.S. and one object for every star in the Milky Way galaxy. Some of the objects in the database are fairly massive -- up to 5TB each -- and could be databases in their own right. Henry expects single-object size to get as high as 500TB by 2016. The secret to dealing with massive data, she says, is to split the objects into chunks, a process called parallelization. In its S3 storage service, Amazon uses its own custom code to split files into 1,000MB pieces. This is a common practice, but what makes Amazon's approach unique is how the file-splitting process occurs in real time. "This always-available storage architecture is a contrast with some storage systems which move data between what are known as 'archived' and 'live' states, creating a potential delay for data retrieval," Henry explains. Another problem in handling massive data is corrupt files. Most companies don't worry about the occasional corrupt file. Yet, when dealing with almost 450 billion objects, even low failure rates become challenging to manage. Amazon's custom software analyzes every piece of data for bad memory allocations, calculates the checksums, and analyzes how fast an error can be repaired to deliver the throughput needed for cloud storage. 3. Mazda Mazda Motor Corp., with 900 dealers and 800 employees in the U.S., manages around 90TB of data. Barry Blakeley, infrastructure architect at Mazda's North American operations, says business units and dealers are generating ever-increasing amounts of data analytics files, marketing materials, business intelligence databases, Microsoft SharePoint data and more. "We have virtualized everything, including storage," says Blakeley. The company uses tools from Compellent, now part of Dell, for storage virtualization and Dell PowerVault NX3100 as its SAN, along with VMware systems to host the virtual servers. The key, says Blakeley, is to migrate "stale" data quickly onto tape. He says 80% of Mazda's stored data becomes stale within months, which means the blocks of data are not accessed at all. To accommodate these usage patterns, the virtual storage is set up in a tiered structure. Fast solid-state disks connected by Fibre Channel switches make up the first tier, which handles 20% of the company's data needs. The rest of the data is archived to slower disks running at 15,000 rpm on Fibre Channel in a second tier and to 7,200-rpm disks connected by serial-attached SCSI in a third tier. Blakeley says Mazda is putting less and less data on tape -- about 17TB today -- as it continues to virtualize storage. Overall, the company is moving to a "business continuance model" as opposed to a pure disaster recovery model, he explains. Instead of having backup and offsite storage that would be available to retrieve and restore data in a disaster recovery scenario, "we will instead replicate both live and backed-up data to a colocation facility." In this scenario, Tier 1 applications will be brought online almost immediately in the event of a primary site failure. Other tiers will be restored from backup data that has been replicated to the colocation facility. Adapting the Techniques These organizations are a proving ground for handling a tremendous amount of data. StorageIO's Schulz says other companies can mimic some of their processes, including running checksums against files, monitoring disk failures by using an alert system for IT staff, incorporating metadata and using replication to make sure data is always available. However, the critical decision about massive data is to choose the technology that matches the needs of the organization, not the system that is cheapest or just happens to be popular at the moment, he says. In the end, the biggest lesson may be that while big data poses many challenges, there are also many avenues to success. This story, "Storage tips from heavy-duty users" was originally published by Computerworld.# Setup IDE: All Text Editor (Install as Python module) Tutorial Video is available on YouTube. Thanks @GDquest for creating a great tutorial video! [![](https://img.youtube.com/vi/IQgLBnPO2uo/0.jpg)](https://www.youtube.com/watch?v=IQgLBnPO2uo) #### 1. Check the generated modules location Check the location of the generated modules. #### 2. Install the modules as the Python module 1. Search and go to the directory `Python.exe` binary is installed. 2. Place the generated modules to the `Lib` directory. Note: Be sure the Python version that you are using So what: The company said it would be reporting a loss for the fourth quarter but no one expected an outlook of $0.67-$0.72 per share in losses. The company said that steel prices may fall 5% to drive the loss. To make matters worse, the company is offering $475 million in debt and 25-million shares of stock in new offerings. Now what: The bad outlook isn't positive but the company will add almost 25% to its shares outstanding with the share offering. Considering both factors, I think this is a stock I would stay far away from. Operating trends are heading in the wrong direction and I don't see any value in a company that's continually losing money. Interested in more info on AK Steel? Add it to your watchlist by clicking here.--- abstract: 'The Mission Accessible Near-Earth Object Survey (MANOS) aims to observe and characterize small (mean absolute magnitude H $\sim$ 25 mag) Near-Earth Objects (NEOs) that are accessible by spacecraft (mean $\Delta v \sim 5.7$ km/s) and that make close approaches with the Earth (mean Minimum Orbital Intersection Distance MOID $\sim$ $0.03$ AU). We present here the first results of the MANOS visible spectroscopic survey. The spectra were obtained from August 2013 to March 2018 at Lowell Observatory’s Discovery Channel 4.3 meter telescope, and both Gemini North and South facilities. In total, 210 NEOs have been observed and taxonomically classified. Our taxonomic distribution shows significant variations with respect to surveys of larger objects. We suspect these to be due to a dependence of Main Belt source regions on object size. Compared to previous surveys of larger objects [@Binzel_2019; @Binzel_2004; @Perna_2018], we report a lower fraction of S+Q-complex asteroids of $43.8 \pm 4.6\%$. We associate this decrease with a lack of Phocaea family members at very small size. We also report higher fractions of X-complex and A-type asteroids of $23.8 \pm 3.3\%$ and $3.8 \pm 1.3 \%$ respectively due to an increase of Hungaria family objects at small size. We find a strong correlation between the Q/S ratio and perihelion distance. We suggest this correlation is due to planetary close encounters with Venus playing a major role in turning asteroids from S to Q-type. This hypothesis is supported by a similar correlation between the Q/S ratio and Venus MOID.' author: - Maxime Devogèle - Nicholas Moskovitz - Audrey Thirouin - Annika Gustaffson - Mitchell Magnuson - Cristina Thomas - Mark Willman - Eric Christensen - Michael Person - Richard Binzel - David Polishook - Francesca DeMeo - Mary Hinkle - David Trilling - Michael Mommert - Brian Burt - Brian Skiff bibliography: - 'MANOS1.bib' title: 'Visible spectroscopy from the Mission Accessible Near-Earth Object Survey (MANOS): Taxonomic dependence on asteroid size ' --- Introduction {#sec:intro} ============ Near-Earth Objects (NEOs) are defined by a perihelion distance $q < 1.3$ AU. The study of NEOs provides access to objects up to 3 orders of magnitude smaller than the smallest observable Main Belt asteroids (MBAs), where most NEOs are thought to have originated. NEOs are also the most accessible objects
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three ladies in the course. In what order we would take the events it was for our own judgment to decide, but the Jew's horse was to belong to that one of us who arrived first at Baron Clootz's house after having fulfilled the conditions. "His proposition was a great success, and I was already in my mind arranging the consecutive order of the items, and going through my circle of acquaintances amongst the pretty women of the district, when I found that the day chosen for the contest was the day of my rendezvous with Madame Rosalba. The day had been chosen for both purposes from the same reason: because the élite of the town would be occupied, and not able to poke their noses into our affairs. "I had, however, confidence in myself, and as I walked away arm in arm with young Waldemar I thought it a good joke. He was still worshiping Rosalba from the footstep of her pedestal, so much so as to want to change his religion for her sake, even, I believe, and become a monk. I often had to listen to his panegyrics upon her. Still after some argument we had persuaded him to come into our contest. I think that he meant to show himself to Rosalba on the Spanish horse, for he was a tolerably good horseman. "I was, without vanity, punctual at my rendezvous at the white château of Rosalba on that Friday afternoon. By her own maid—for there was not another soul in the house; they had all gone to the funeral—I was taken to her boudoir in the tower, and at the top of a long stone stair. The shutters were closed, the room was half dark, and, when you came from outside, as cool as a church. There were a great many white lilies, so that the air was heavy with their scent. Upon a table were glasses, and a bottle of the best wine that I have ever tasted, a dry Château Yquem. This made my third bottle of the day. "Rosalba also was there. She was as ever very plainly attired, but she had shaken herself, with one shake, into very great beauty. "If what happened to me in this tower seems somehow wild and fantastical, and more like a fairy tale or a ghost story than a romance, the fault is not mine. It is true that the day was hot; a thunderstorm followed it in the night; and that as I came in from the white road, heavy in my riding boots, I was not too sure of my head. I may even have been more in love with her than I myself knew, for everything seemed to me to turn on her, and my bottles and my wildly galloped races to be only the reasonably fit initiatory ceremonies to this great moment of love-making. But I remember well all that happened. "I had not much time to give away. Light-headed as I was, with the room swinging up and down before my eyes, my words came easily to me, and I had her in my arms pretty soon, her clothes disheveled. She was like a lily in a thunderstorm herself, white and swaying, her face wet. But she held me back with her outstretched arms. 'Listen for one moment,' she said. 'Here we are all alone. There is no one in the house but we and my maid who brought you here, that pretty girl. Are you not afraid? " 'Arvid,' she said, 'have you ever heard the story of Don Giovanni?' She looked at me so intently that I had to answer that I had even heard that opera about him. 'Do you remember, then,' she said, 'the scene in which the statue of the Commandante comes for him? Such a statue there is on the tomb of the General Zumala, in Spain.' I said, 'Oh, let it keep him down in it, then.' " 'Wait,' said Rosalba. 'Rosalba belonged to General Zumala Carregui. When she betrays him, poor Rosalba must disappear. But then, an opera must have a fifth act to it sooner or later. And you, my star of the north, are to be the hero of it. You have your honor in the matter, as if you were a woman. You would have no mercy on St. Mary of Magdala. Rosalba was such a shining bubble, and when you break her, a little bit of wet will be all that you get out of it. But it was time that she went. The people, and her creator even, were becoming too fond of her. You give her her great tragic end. No other man in the world, I think, could have done that so well. You are well worthy of coming in.' " 'Let me come in, then,' I gasped. " 'You have no pity on poor Rosalba at all?' she asked. 'That she should lose her last refuge, and be haunted and doomed forever—that means nothing to you?' " 'You yourself have no pity on me,' I cried. " 'Ah, how much you are mistaken,' she exclaimed. 'For you, Arvid, I am worried, I am terribly sorry. An awful future awaits you—waste, a desert—oh, tortures! If I could help you, I would; but that is impossible to me. The thought of Rosalba will never be any good to you; her example cannot help you. The thought of this hour might, afterward, do you some good, but even that is not certain. Oh, my lover, if to save you I made you a present of a lovely horse, all saddled within my stable, fiery enough to carry you away in a gallop from this terrible fall and the perdition of us both, and if I sent my maid, that pretty girl who showed you up here, with you to find him, would you not go? " 'For soon,' she said, drawing herself up to her full height, her hand still on my breast, as mine in hers, and speaking in the manner of a sibyl, 'it may be too late, and we shall hear the fatal step on the stair, marble upon marble.' "In our agitation her dark hair, which used to hang down in ringlets on both sides of her face, was flung back, and I saw that she had indeed the brand of the witch upon her. From her left ear to her collar bone a deep scar ran, like a little white snake–" At these words of the Baron, Pilot cried out: "What! What are you saying?" "I said," said the Baron patiently, pleased with the impression made by his tale, "that from her left ear to the collar bone ran a scar, like a snake." "I heard it," cried Pilot. "Why are you repeating my words? The milliner of Lucerne, Madame Lola, had on her neck just such a scar, and I have this hour described it to you." "You have not said one word of it," said the Baron. "Have I not?" cried Pilot to me. I said nothing at all. I thought: I am dreaming. By now I am quite sure that I am dreaming. This hotel, Pilot, and the Swedish Baron are all parts of a dream. Good God, what a nightmare! I have at last lost my reason for good and all, and the next thing that will happen will be that Olalla will walk in through that door, swiftly, as she always comes in dreams. With that thought I kept my eyes on the door. From time to time, while we had been talking, new guests had come in from the outside, to sit down or to walk through the room to the inner apartments of the hotel. Now a lady and her maid came in, and passed us quickly and quietly. The lady wore a black cloak, which disguised her face and figure. The maid had her hair wrapped around her head in the Swiss way, and carried the shawls. Both looked so demure that not even the Baron gave them more than one glance. It was not till they were already gone that Pilot, suddenly stopping in his heated debate with the Baron, stood up like a statue, staring in their direction. When we asked him, laughing—for we had drunk enough to think one another ridiculous—what was the matter with him, he turned his big face toward us. "That," he cried, deeply moved, and even more so by the sound of his own voice, "was she. That was Madame Lola of Lucerne." The lightning of madness had struck, then, but it had hit Pilot and not me. Still no one could tell what would happen next; and indeed at his words it seemed to me that there had been something familiar about the lady. Pilot began to pull his hair. "Come, my boy," I said, taking hold of his arm. "It is not necessary to be mad. We will go together and ask the porter, who will know her, if this lady be not the midwife of Andermatt, who will be found to have nothing whatever in common with the Maid of Orléans." Still laughing, I dragged him to the porter's _loge_ and began to question the bald old Swiss about the newcomers. The porter was at first busy counting up various pieces of elegant luggage, and did not pay much attention to us. "Come," I said to him, "here is a
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4564, 273, 1897, 4321, 13, 672, 344, 11372, 253, 4836, 273, 10620, 342, 253, 19423, 13638, 31245, 3988 ]	alley. He stood there for two minutes, at the end of which he walked to the small table on which sat the ten small glasses of vodka. He picked up one of the glasses and knocked back the shot. When he finished he said to everyone, "Onwards to Charleston." Chapter 31: Gone in the Night The fundamental idea was that all of the conspiracy and planning, all the talking and risk-taking, and all of the strange friendships and relationships would result in some great action; this action being, of course, the theft; the heist of a lot of grade C artifacts from the Hermitage Museum in Saint Petersburg, Russia. This was not a Tom Cruise (Mission Impossible), Sean Connery (James Bond) type of action. Maybe it was a tribute to the brainpower employed by the team in its planning. Maybe it was luck. Maybe it was due to soft security by the Hermitage staff. Or maybe it was due to a legacy of bad karma drifting down through the years from the rampages of Lenin and Stalin. Who knows? The fact is, the heist went off without a hitch. The team did have to make one very important change to the plan at this point. After much discussion, mostly between Roger and Plouriva, they realized it simply wouldn't work having Roger describe to Plouriva beforehand the types of artifacts he wanted from the warehouses. He would have to be part of the heist team and choose the goods that were taken. Gwen didn't like this conclusion at all. She had planned on sitting comfortably in the Corinthia, playing with Roger and the towels that came off the heated towel rack she loved so much. Now her husband was walking into the line of fire. And it might turn out to be a withering fire. But she kept her mouth shut when it became clear Roger wanted to do this, and that it was necessary. Roger used their telepathy to tell her it was all right. On D-Day morning Roger went alone to the Hermitage, as usual. Just before lunchtime he left, and met Plouriva outside. She walked him to her office where he spent the remainder of the day, in full view of the grounds staff. Maybe they thought he was the boss' new squeeze, and if that was the case, the staff knew enough not to stick their noses into it. Early that morning Plouriva got a call from Constantine (on a secure line) saying eight large flatbed trucks were waiting at a construction site two miles from the museum. With this confirmed, Plouriva went into the main museum building and found her counterpart, the head hoity-toity guy that ran internal operations. She told him that today was the day to move the crates from Vladivostok out of the basement work areas, to the warehouse areas, where she would store them for the duration of the exhibit. He looked at her like she was crazy, and said, "Are you crazy? Why didn't you give me some notice?" She said, "Look, today is the day the construction guys I know off-loaded their trucks at their site. Today is the day the trucks are available. And so today is the day I can get the crates out of your way and out of your building. What's the problem? You want the crates to stay, fine by me." The hoity guy was exasperated, and looked it, but from past experience he knew enough to not fuck around with Plouriva. The last time he did that, his parking spaces didn't get plowed for two weeks from under a late May storm that dumped two feet of snow on the city. So he bit his lip, called down to the basement level and told the guys down there that today all the crates would be going. This stirred up a hive of activity that Plouriva was pleased to witness. The sixteen huge crates were cleared and lined up ready for loading. Plouriva went back to her office and smiled at Roger, who was looking at a Russian fashion magazine. He couldn't figure out why Plouriva, of all people, would have a magazine like this in her office, but he enjoyed looking at the Russian models. He was pleased to see the Russian fashion world had not succumbed to the disease the western fashion world has succumbed to, which is a population of emaciated, juvenile, stick-figure models. These Russian babes had substance to them. Plouriva called Constantine and spoke one word: "Go." At 2pm eight flatbeds entered the Hermitage compound through one of the service gates and rumbled up to the rear of the building that had 1285 rooms, including one heck of a lot of bathrooms. While the hoitys loaded the crates onto the trucks, Plouriva called the two gay guys and told them to stop by her office when they came on duty that evening at 6pm, because she had the forms they had asked for to apply for jobs in her division. This was the signal that the job was on for that night, as planned. She thought she heard choking at the other end of the phone line, but that could have been her imagination. She, on the other hand, was Cool Hand Luke. She was amazed she was not nervous, not even a little. Excited, maybe, but she had no premonition of disaster. When the head hoity called her and told her the crates were loaded, she jumped in her jeep and zoomed the quarter mile over to the museum. She parked, waved to the hoity, gave him the figure behind her back, and jumped on the running board of the lead truck. She gave the "convoy ho" signal, and the giant diesel engines chugged the trucks into motion. A massive cloud of smoke drifted towards the snow white walls of one of the great museums on the planet. The hoity guy said good riddance to the crates, and the same to the head grounds yahoo. The convoy meandered away from the museum area and disappeared into the surrounding pine forest. Most of the hoitys didn't know what went on out in "the woods", and didn't want to. Warehouses without end, dumpsites, a quarry, maintenance sheds, vehicle garages, water plants, sewage plants, and god knows what else filled these surrounding lands. This was Plouriva's territory. Plouriva's plan was to simulate a breakdown in the lead truck when it got to the warehouse district, when she did by opening the hood of the lead truck. She used an old military forklift to off-load two crates and make it look like they were heading for storage. The eight drivers and eight truck passengers hung around the area looking bored, in case any security patrols happened by, while two guys pretended to work on the lead truck engine. Plouriva had made sure that none of her staff would be working in this area. All was quiet. Plouriva hoofed it back a mile to her office complex and found Roger still looking at the fashion models. She wondered how long he could do this. It was 6pm, and most of the staff had left for the day. She called the security office and told them of the truck breakdown. They had nothing to say. With that, she turned to Roger and said the Russian version of, "Game on." Roger put down the magazine, looked at her, and said, "Now what." She turned off her computer, took a last look around the space that had been her office for twenty years, and with only a twinge of sentiment, flipped off the lights. They walked outside, hopped into another jeep, and disappeared into the forest. Plouriva drove to the warehouse complex and parked near the line of trucks. They got out, and Roger looked around. He counted thirty-one large, one-story, wood buildings within sight. He asked, "Is this all?" Plouriva got the American joke, and told him there were four other warehouse complexes similar to this. He said, "Wow." He looked at her, and she looked at him, and it dawned on them both that from this point forward the job would be shear improvisation. The sixteen guys lounging around showed no emotion; they had been part of heists before, and calmly waited for Plouriva's orders. All of them had paper bags of food, and all of them carried handguns under their shirts or on the floors of the trucks. From her jeep Plouriva grabbed a large pair of bolt-cutters and two flashlights. The warehouses were locked with large, heavy padlocks. Plouriva was solid as a rock as she led the way to the first building, cut the lock, and entered. The lights worked, surprisingly, as this may have been the first time in ten years that anyone had turned them on. Roger entered and looked around. The first thing he saw was a small painting of a Russian factory. The smokestack was billowing and the workers were filing in one doorway and out another. This was Russian realism from the 1950s. The painting was hanging by wires from one of the horizontal ceiling beams. Roger scanned the packed interior, with aisles running in perpendicular directions, and he looked at Plouriva for guidance. Plouriva had no guidance to provide, and shrugged her shoulders. With that as a statement of reality, Roger realized the same thing Jinny had realized a couple of days earlier, when he faced the task of dealing with the Hermitage perimeter security
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1652, 878, 273, 15, 187, 187, 20964, 13, 275, 247, 2791, 6982, 13, 352, 310, 417, 253, 2136, 273, 667, 4849, 273, 4292, 432, 835, 309, 16270, 10229, 285, 10067, 10509, 347, 14905, 275, 247, 1959, 5948, 15, 1198, 1223, 841, 18595, 403, 2223, 32487, 275, 2426, 273, 35857, 23027, 13, 597, 403, 7960, 523, 30487, 1149 ]	)?” Some will probably think Lenski fabricated her depiction of the Puritans from her own imagination. However, in the forward she carefully documents that much of her story is based upon assorted original sources and she includes an ample bibliography at the end. Of her sources, Lenski writes, “I have incorporated in my story many quotations taken from early New England writers. It is these phrases, so rich and suggestive, in the original sources, which give this long-past age a glow of reality and truth. In them we hear our founders speak, think, and act. They are the rightful heritage of American children (page XI).” Lenski also does a service to history by pointing out that, while the Puritans seem unduly harsh to us, in their time Christmas was marked by drunken bawdiness and in terms of severity Puritans were “soft” on crime as they had only ten crimes punishable by death whereas England had nearly thirty. In her trial before town authorities for introducing the children to Christmas, Shrovetide, and May Day, in her defense Charity Cummings says, “We came to this fair land to build a new world, a New England. If I then look back to the Old, if I remind you of the life we lived there, ‘tis because I wish to preserve the best in the old ways for a goodly heritage. So away with Old England’s wrongs, I beg you, but hold fast to its good, and make your new world the richer (215-216).” Likewise, we as their descendants should not dismiss the Puritans in their entirety but rather retain from them those dispositions that have withstood the test of time while guarding against those darker tendencies that in various forms have plagued mankind throughout all of recorded history and not just among the Puritans. Taken by itself, Puritan Adventure does not paint a complete picture of the pivotal contributions to the American way of life made by this sect. However, when studied alongside other introductory sources such as Pilgrims & Puritans by James and Lincoln Collier, the reader will have a good understanding of these complicated Forefathers. While the movement claims to support individuality, one of its leaders, Kevin Swanson, claims you are an materialistic existentialist if one does not follow his exact life-path and produce more than three children. If it is selfish not to have kids, why isn't it selfish to expect everyone else to take care of your offspring? He claims Hispanics have an above average birthrate since they have not been exposed as long to the American public school system. I wonder if this demographic would be as fecund if they were not given all manner of handouts such as WIC and free emergency medical care. Prepare for more coffee bars, electric guitars, and tattooed pastors with rings in their noses in a pulpit near you. From this article on the blog at Light House Publishing, the new head of this organization (Leith Anderson) might talk tolerance, but his minions are anything but as they prevented New Age expert Brian Flynn from discussing a number of mystical practices infiltrating the church. Wednesday, November 01, 2006 According to Dr. Albrecht the plan is essentially a food registration act that will permit the government near total control over the food supply and make it easier to drive the small farmer out of business. Big shots that usually dismiss such concerns who have so much extra money on their hands that they own horses might change their tune upon learning that there are provisions in these regulations that one must inform bureaucrats each time you take Trigger off your property. Furthermore, it is pointed out that those with registered animals will be required to keep a log of all visitors to their property to be turned over to the government encase of "disease outbreak". Why don't you enact a bowel movement and flatulence registration act while you are at it since toxins can be released into the atmosphere through this manner as well. Monday, October 30, 2006 Since a number of the trustees making this decision are members of Congress, does this mean if the American people employ tactics of a similarly seditious nature as the Gallaudet protestors that such members of Congress should be forced to resign? Wednesday, October 25, 2006 Tuesday, October 24, 2006 While Kevin Swanson does a good job of poitning out the failings of the socialistic public school system, frankly, I would not want to live in his brand of utopia either as in this edition of the program he believes girls should be married around 16 years of age and have 16 children over the course of their fecund years. While people did marry at ridiculously young ages years ago, they also died a whole lot earlier on average as well. I have seen pictures of my own great-grandmother who died in her mid 40's and she looked like she was pushing 70. Control by church authorities over matters not definitively spelled out in the Bible is still too much control. Monday, October 23, 2006 In an informative episode of his program dealing with the decline of manliness in our society, Albert Mohler complained that mostly women called in to discuss the issue. However, since his program is recorded at 5 pm, weren't the real men in America out working? Furthermore, isn't it the perceived epitome of feminity to yap one's trap about the inner recesses of one's feelings with someone you don't even know? Frankly, what manly man is going to want to do that on national radio? While a vital topic, at its conclusion, it veered to close towards sterotypical depictions of manhood rather than Biblical ones as it was insinuated hardware stores were a proper place for real men to hangout. Firstly, are those not given over to physical pursuits not to be viewed as manly; why aren't certain parts of the library considered sufficently masculine? For are not war and conflict as much about the mind as the body? Perhaps we should castigate as limpwristed those unfamiliar with sagas of adventure and the intricacies of critical thought if the same kinds of insinuations are going to fly about those lacking fetishes over power tools. Secondly, if someone is manly, frankly, they don't really need to be hanging around a group of men. If that's what one is craving to do, in my opinion that is itself a sign that one might secretly not be as brawny as one tries to lead others to believe and actually a bit of a flake at heart. Saturday, October 21, 2006 Two of comicdom’s most legendary characters are none other than Superman and Captain Marvel, more popularly known as Shazam. To the unfamiliar, at first glance the two heroes seem almost indistinguishable from one another with Captain Marvel wearing the spiffier costume while Superman possesses the more iconic insignia. Superman/Shazam: First Thunder chronicles a contemporary interpretation of the first meeting between the World’s Mightiest Mortal and the Man of Steel. And though not the best-drawn story featuring these characters that have both been around since the early days of comic books, this graphic novel provides a bit of insight into the differences between the two. For example, from a dialogue between these foremost costumed adventurers, the reader learns that while Superman might have superior senses, Captain Marvel is more immune to the effects of magic. It is doubtful Superman/Shazam: First Thunder will be remembered as a graphic novel classic. However, fans will nevertheless get a kick out of seeing these legends team up. Monday, October 16, 2006 In a classic Simpsons’ moment, at their show’s equivalent of Disney World dedicated to the parodies of Tom and Jerry known as Itchy and Scratchy, a giddy Homer is duped into trading his money for the amusement park’s imitation play currency which can’t be spent on anything at the park. The scene is humorous in that only Homer would be among those stupid enough to fall for such a scheme. At one time, it use to be a sign of discernment if the prudent citizen was not taken in by such snake oil. However, if a bunch of grubby beatniks have their way, one’s willingness to fall for such nonsense will serve as a measure of one’s devotion to and support of the COMMUNITY. According to the June 2006 Hyattsville Life And Times, the cities of Hyattsville, Mount Rainier, and Brentwood will be acquiring a local currency to be called the “Anacostia Hour”. Those hoodwinked into accepting this tender can use it to purchase goods from businesses part of the program and even pay employees “willing” to accept this glorified monopoly money. The purpose of this dubious means of exchange as stated in the Hyattsville Life & Times is to “keep people shopping in the local community.” Maybe if a given municipality had stores worth shopping at or free from the dregs of humanity prowling the aisles of such establishments, residents wouldn’t mind spending their regular money in the area. But bigshots in these here parts insist upon either “high end retailers” or idiosyncratic specialty merchants selling novelty junk common folks have little need of. Furthermore, in a market economy, it is not the business of any collection of individuals from where I acquire goods and provisions classified as legitimate in a free society. For while these proposals are often packaged in terms of civic enthusiasm, they are merely contrived gu
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253, 2914, 10175, 326, 253, 2143, 434, 24642, 369, 1754, 327, 4980, 10485, 610, 15, 346, 42, 1642, 326, 368, 513, 417, 11606, 479, 937, 29161, 9577, 15, 346, 42, 871, 752, 309, 717, 3981, 15, 309, 1239, 253, 7211, 273, 247, 5974, 273, 634, 35893, 449, 187, 187, 998, 19337, 16222, 954, 273, 521, 16157, 281, 253, 4410, 8663, 434, 20417, 9261, 15 ]	the past year and a quarter, it had captured 66 German spy handlers and 1,596 German agents, including 1,338 in western Ukraine, Belarus, and the Baltics, with hundreds of incidents of live fire at the border. Over the first four months of 1941, at least 17,000 trains were reported to have ferried German troops and heavy weapons to Soviet frontiers. Was it certain war? Internally, the British had dismissed the intelligence regarding Hitler's preparations for a war against the Soviet Union, but now, thanks to the Enigma decoding, they had discovered that Hitler was ordering more and more of the Luftwaffe transferred eastward, away from bombing sites for the UK. Still, the British attributed the eastern buildup to a "war of nerves" being waged to force concessions from Stalin. Stalin knew that the Germans had ceased using the Trans-Siberian to transport their diplomatic pouches to and from Tokyo, and Sorge reported (April 17) that the Germans would also cease to use the Trans-Siberian for the import of critical rubber from Japan. But Sorge undercut this message, noting that "the tension in relations between Germany and the USSR was decreasing," which meant the Germans might not follow through on their intention to cease using the Trans-Siberian. He also wrote of supposed factionalism within Nazi ruling circles and suggested that the "pro-war faction" had not gained ascendancy. Sorge added: "The German embassy [in Tokyo] received a telegram from Ribbentrop stating that Germany would not launch a war against the USSR if the latter did not provoke it. But if the war turned out to be provoked, then it would be short and end with the severe defeat of the USSR. The German general staff has completed all preparations." On April 22, Sándor Radó ("Dora"), a Hungarian Communist and Soviet military intelligence operative, reported from Geneva a date of June 15 for an attack on Ukraine. On April 23, Stalin and Molotov decreed the formation of large numbers of new artillery and parachute units with forced production of equipment. The next day, Stalin phoned Ilya Ehrenburg to tell him that the second and third parts of his anti-German novel, _The Fall of Paris,_ would now be published. Only four days earlier, Ehrenburg had been informed that the censor had rejected it. Rumors spread that the despot had personally approved the antifascist book. On April 25, Golikov estimated the presence of 100 German divisions on the USSR's western frontiers, an increase from the previous month. On April 25–26, some three and a half months into his work, Tupikov sent a long message to Golikov on Germany's buildup in the east, stating plainly that the Soviets were the "next enemy" in German war planning, and that "the timing for the beginning of a conflict could possibly be near and, for sure, during the course of this year." A worried Schulenburg, in mid-April, had engaged his staff to draft a long memorandum arguing against a titanic war and, with the facilitation of Ribbentrop and Weizsäcker, who also thought the war a mistake, had traveled to Berlin, but Hitler put off seeing him for two weeks. Finally, on April 28, the Führer granted an audience. Schulenburg's memo was sitting on Hitler's desk (he made no mention of it). Schulenburg evidently stated that "Stalin was prepared to make even further concessions to us," including ramping up to 5 million tons of grain the next year. In fact, Mikoyan could barely find, let alone transport, 2.5 million tons of grain, and it was not clear how the Germans could pay for more grain without yielding vital armaments. Hitler, noncommittal and discourteous, said at parting, "Oh, one more thing: I do not intend a war against Russia!" In London, Maisky was effectively paralyzed by Stalin's position vis-à-vis Britain. On April 30, Churchill's private secretary told the Soviet envoy, "In Conservative circles, one hears the following argument. If Germany attacks the Soviet Union (as many now believe will happen), the USSR will come to us of its own accord. If Germany does not attack the USSR, it will do nothing for us anyway. So is it worth courting the USSR?" Maisky burst out laughing. That same day, "Elder" reported to Moscow, based on conversations in Göring's air ministry with the liaison to the foreign ministry, that "the question of the German attack against the USSR has been definitively decided and its onset can be expected any day. Ribbentrop, who until now had not been a supporter of an offensive against the USSR, knowing Hitler's firm resolve on this question, has taken the position of support for an attack on the USSR." "Elder" was spot-on: that very day, Hitler settled on a date fifty-three days hence—June 22. Neither the German invasion of Greece ("Marita") to compensate for Mussolini's failures nor of Yugoslavia (Operation "25") had a material effect on Barbarossa. Many of the divisions earmarked to take part in the Balkans never saw fighting; some were never even sent. Before May was over, all German units that had taken part in the Balkan campaign were back at their positions on the Soviet border. The delay by about five weeks from the original target stemmed mostly from deficits of key equipment in what, after all, was a colossal undertaking. Indeed, "Corsican" had reported (April 28) that Germany was experiencing severe shortages—and therefore would need to expand economic relations with Japan and the Soviet Union, in the latter case "by force." He had heard one top German official state that "the Russians must supply Germany with more raw materials and foodstuffs, without demanding that Germany had to fulfill Soviet orders exactly or by short deadlines." "Elder," too, reported the possibility of Germany engaging in blackmail. The ultimatum canard—which never formed part of Hitler's plans—had contaminated even the best-placed, most reliable Soviet spies. ### NO ARMY IS INVINCIBLE On May 4, Hitler delivered a peroration to the Reichstag detailing how he had smashed Poland, Norway, Belgium, Holland, France, Yugoslavia, and Greece. "The German armed forces have truly surpassed even themselves," he bragged. "Infantry, armored, and mountain divisions, as well as SS formations, battled without rest, in bravery, endurance, and tenacity to achieve their goals. The work of the general staff has been outstanding. The air force has added new heroic deeds to its historic glory. . . . Nothing is impossible for the German soldier!" He concluded: "The German Reich and its allies constitute a power that no coalition in the world can surpass. German armed forces will unremittingly intervene in the course of events whenever and wherever it will be required." The signals were getting even more confounding. In Tokyo, the day after Hitler spoke, Japanese foreign minister Matsuoka reassured German ambassador Ott that "no Japanese prime minister or foreign minister could ever be able to maintain Japan neutrality in the event of a conflict between Germany and the Soviet Union. In such an event, Japan, naturally, would be compelled to attack Russia right behind Germany." That would have violated the Soviet-Japanese Neutrality Pact, and it did not comport with Japan's internal deliberations. That same day, a dispatch from "Corsican" in Berlin went to Moscow indicating that a press person from the German economics ministry had told the staff that Germany wanted peace on its eastern frontiers, for it would soon attack the British-controlled Suez Canal. Germany would demand that the USSR attack Britain on the side of the Axis, and, as a guarantee that Moscow would follow through, Germany was going to occupy Ukraine and possibly the Baltics. Stalin decided to send some signals of his own. Also on May 5, 1941, at 6:00 p.m., Timoshenko opened the graduation ceremony in the Grand Kremlin Palace's combined Andreyev-Alexander hall (the venue for party congresses) for sixteen military academies and nine military departments in civil institutions, with some 1,500 attendees, including professors as well as defense commissariat, government, and Comintern personnel. The graduates had entered the academies in 1937 or 1938. When Timoshenko announced that Stalin would take the dais, the eruption would not die down until the despot glanced at Timoshenko, who quieted the hall. "Comrades, permit me in the name of the Soviet government and the Communist party to congratulate you on the completion of your studies and wish you success in your work," Stalin began, going on to underscore, over the course of forty minutes, the enormous strides in the Red Army's material base. But he criticized the academies' curriculum. "I have an acquaintance who studied at the Artillery Academy," Stalin noted. "I looked over his notes and discovered that a great deal of time is being spent studying cannons that were decommissioned in 1916." This acquaintance was his elder son, Yakov, who was in the audience. "Is it like that, comrade artillerymen?" Shockingly, Lieutenant General Arkady Sivkov, head of the Artillery Academy, shouted from one of the front rows that the school's curriculum was based on modern weaponry. "I ask that you do not interrupt me," Stalin answered. "I know what I am saying. I read the notes of a student of your academy." Stalin devoted most of his remarks to the Red Army's technological transformation.
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24589, 342, 271, 34052, 353, 740, 7368, 285, 30503, 29331, 15, 1284, 2080, 347, 309, 2096, 309, 651, 878, 281, 452, 253, 49535, 406, 7430, 69, 8985, 275, 619, 1854, 534, 15, 1359, 476, 309, 13204, 436, 8985, 342, 29331, 32, 187, 187, 34, 27, 187, 187, 1394, 476, 897, 418, 1836, 35368, 275, 1340, 281, 5522, 634, 21011, 15, 187, 510, 418 ]	string body, string attachment) needs a string type for the argument attachment. Whereas you're passing an object of type StorageFile, which you get by calling await folder.GetFileAsync(name); If you want to pass the file path of the attachment you can do: await kioskclient.sendEmailWithAttachAsync(email_address, "Visit Photo", message, file.Path); Practical Scriptwriter Practical Scriptwriter is screenwriting software supporting various US and UK script formats (Stage, Screen, Television and Radio) as required by the BBC and US Screenwriting industry standards. The software runs on the Windows platform only. The application is notable due to the separation of formatting information from the script itself. This separation is the opposite of a traditional WYSIWYG Word Processor, the data file format does not contain font and layout metadata, this is only applied during the formatting process. The software uses a proprietary file format identified by the .FSC file extension. Originally released in 2005, the software was rewritten using Windows Presentation Foundation in 2012. References Category:Screenwriting software Category:Windows text-related softwareA full duplex radio (FDR) or full duplex communication scheme refers to a communication scheme for simultaneously supporting transmission and reception using the same resource in one user equipment (UE). In this case, the same resource refers to the same time and the same frequency. FDR communication or full duplex communication is referred to as two-way communication. FIG. 1 is a conceptual diagram illustrating a UE and a base station (BS), which support FDR. Referring to FIG. 1, in a network state that supports FDR, there are three types of interferences. First interference is intra-device self-interference. The intra-device self-interference means that signals transmitted from a transmission (Tx) antenna and received by a receiving (Rx) antenna act as interference in one BS or UE. Since the signals transmitted from the Tx antenna are transmitted with high power and a distance between the Tx antenna and the Rx antenna is short, the transmitted signals are received by the Rx antenna without almost of attenuation, and thus, are received with higher power than a desired signal. Second interference is UE to UE inter-link interference. In a network that supports FDR, the UE to UE inter-link interference is increasingly caused. The UE to UE inter-link interference refers to interference caused by uplink signals that are transmitted from a UE and received by a neighboring UE. Third interference is BS to BS inter-link interference. Similarly, in a network state that supports FDR, BS to BS inter-link interference is increasingly caused. The BS to BS inter-link interference refers to interference caused by signals that are transmitted between BSs or heterogeneous BSs (pico, femto, and relay) in a HetNet state and received by an Rx antenna of another BS. Among the three types of interferences, the intra-device self-interference (hereinafter, referred to as self-interference) is influence of interference caused only in FDR. In order to manage FDR, the most serious problem is cancellation of self-interference.Gibson Freezer Parts Need Help? Get Questions Answered Instantly. 1-877-477-7278 The Gibson appliance brand began as a merger between two icebox manufacturing companies in Michigan in 1908. It has evolved mightily since that time, and is currently a well-respected division of Electrolux. From the first upright freezer in 1946 to its current, varied energy efficient models found in homes throughout America, Gibson freezers -- both upright and chest -- continue to be recognized for outstanding capacity, ease of use, and performance. Whether you've lost your freezer lock key, you need a new deodorizer, your door handle is damaged, or an integral component like a defrost thermostat or compressor needs to be replaced so your food stays chilled, we have the Gibson freezer part selection and guidance to help solve your problem.1898–99 Scottish Cup The 1898–99 Scottish Cup was the 26th season of Scotland's most prestigious football knockout competition. The Cup was won by Celtic when they beat Rangers 2-0 in the final. Calendar First round First round replay Second round Second round replay Second round second replay Quarter Final Game Abandoned Quarter Final replay Semi-finals Final See also 1898–99 in Scottish football References RSSF Scottish Cup 98-99 1899-1900 Cup CupTORONTO -- Netflix says it's planning on cracking down on users who use virtual private networks and proxy services to view content not available in their countries. Many of the company's distribution deals with major studios and content providers are negotiated on a regional basis, meaning certain titles are only available to users in certain countries. Some Canadians use VPN services to stream Netflix movies and TV shows available in the United States, which according to the website Netflixable has around twice as many available titles. The U.S. version of Netflix also features more Hollywood blockbusters and recent seasons of popular network shows than its Canadian counterpart. In a blog post, David Fullagar, Netflix's vice-president of content delivery, said the company is making progress in licensing content across borders but is now implementing new measures to end the use of so-called unblockers and other proxy services. The company has always been against the use of such services and has said it takes measure to shut them down, but Fullagar said the company is "evolving" its approach to the problem and the new strategy will be in place in the coming weeks. According to a April 2015 report by Media Technology Monitor, roughly two in five English-speaking Canadians has a subscription to the video-streaming service, with nearly one-third saying they had accessed the American version of the service.Category Archives: QA Some people describe addiction as a spiritual disease as much as it is a mental, emotional or physical one. Just like depression and other mental illnesses, addiction can be seen as being a deep disconnect within us that severs our connection with our higher power as well as the interconnectedness of our different parts. We… For those living with addiction, many of us experience what we often refer to as hitting “rock bottom,” that time and place where we feel we’ve fallen as low as we possibly can. In this place, there are some common things many of us think, feel and experience that are memorable and that stay with… Although depression is a debilitating and paralyzing mental illness, it often goes undiagnosed and therefore untreated. There are a number of reasons why we never reach out for help, many of them having to do with the stigma that still surrounds addiction in our society and in our communities. There is still a common misconception… There are many factors that can contribute to our addictions – our family’s experience with substance abuse, our genetic makeup, our mental illnesses and our lack of healthy emotional coping skills. One factor we often ignore but that can be particularly problematic is boredom. When we think of boredom, we think of it as being… A popular wellness trend is decluttering, clearing away the chaos and confusion in our physical spaces, in our lives, and in our minds. When we declutter, we take mindful steps to simplify both our surroundings and our internal environment. We look at what elements are holding us back, in our daily lives, in our homes,… A huge contributor to our addictions and mental health issues is our lack of self-worth. We feel insecure about who we are, about our illnesses, about where we are in our lives. We feel ashamed of ourselves. Our shame and lack of self-worth make us think we don’t deserve to be happy or experience the… When we’re struggling with addiction, the logical thing would be to want to get help for the illness that is destroying our lives. When we have a broken bone or any other medical issue, we get help. Why do we so often resist getting the help we need to kick our addictions? What is it… As parents, our children’s well-being is of the utmost importance to us and is usually our highest priority. We are responsible for their upbringing and their health, and we take our responsibility very seriously. We feel honored to be their parents. When we’re struggling with addiction, our priorities can become totally skewed. The toxic substances… Those of us living with addiction know just how painful and overpowering addiction can be. We get caught in cycles of using, desperately wanting to quit, feeling remorseful and depressed about our substance use and our inability to stop, quitting for awhile, and then falling right back into using again. This cycle can repeat itself… If you are struggling with thoughts of suicide, PLEASE call the National Suicide Prevention Lifeline: 1-800-273-TALK (8255). Self-medicating is the term used to describe our use of addictive substances and behaviors to relieve our mental and emotional pain. Rather than actual medication or natural remedies that would help us to heal, we’re relying on toxic…Q: MongoDB field level encryption with Lambda and Atlas how to include mongocryptd I try to implement MongoDB client field level encryption with an Atlas M10 cluster and AWS lambda. As far as I understand I would need to have the mongocryptd binary in my path which. How can I bundle this binary with lambda? A: You can use Lambda Layer in order to package your dependencies. The L
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881, 15103, 12038, 5673, 551, 187, 186, 10987, 9, 19350, 5455, 2876, 10, 2228, 187, 94, 187, 187, 881, 40050, 12038, 5673, 551, 187, 186, 10987, 9, 19350, 5455, 13, 36191, 40148, 2876, 10, 2228, 187, 94, 187, 187, 881, 11629, 12038, 5673, 551, 187, 186, 10987, 9, 4896, 4511, 5455, 13, 7212, 5455, 2876, 10, 2228, 187, 94, 187, 187, 881, 11327 ]	addictive FPS fare: Collect power-ups, armor and weapons as quickly as possible, turn your enemies into piles of pixelated goo and repeat. Sounds simple, yes, but also endlessly appealing and difficult to master. The only hitches found currently are the lack of certain features (now that the 30 minute to one hour queues of last week are gone) such as some forms of stat tracking and a few of the achievements that have been taken down temporarily. Other than these few bumps in the road, Quake Live succeeds as a beta because if you missed the word “beta” below the game’s current logo, you would barely notice it’s a beta test at all. There are no words from id Software on an official release, but expect it to be a while before Quake Live moves on from beta as there are plenty more features id Software are planning to add. Can someone say “premium accounts“? Check back for future updates. (Images via Gamers Lab & Games Radar)PALO ALTO — Maryam Mirzakhani was best known for breaking the mold — and for doing it the hard way. As a high school student in her native Iran, Mirzakhani competed for the International Mathematical Olympiad in the 1990s– a competition in which girls seldom participated. Related Articles Stanford professor first woman to win Fields Medal Years later, the world-renowned mathematician, by then a Stanford professor, became the first and only woman to receive the prestigious Fields Medal, often described as the mathematician’s Nobel Prize. Mirzakhani, who lost her long battle with breast cancer on Saturday at age 40, was described by her colleagues as a remarkable mathematician whose skill and passion was unmatched. “Maryam is gone far too soon, but her impact will live on for the thousands of women she inspired to pursue math and science,” said Stanford President Marc Tessier-Lavigne. “Maryam was a brilliant mathematical theorist and also a humble person who accepted honors only with the hope that it might encourage others to follow her path. “Her contributions as both a scholar and a role model are significant and enduring, and she will be dearly missed here at Stanford and around the world.” The eight-decade-old Fields Medal is given every four years to no more than four mathematicians, all of whom are 40 or younger. Mirzakhani, a Palo Alto resident, received the award in 2014 in Seoul, South Korea. “This is a great honor. I will be happy if it encourages young female scientists and mathematicians,” she said at the time. “I am sure there will be many more women winning this kind of award in coming years.” Mirzakhani — known for willingly taking the difficult, complicated path to solve a mathematical problem — studied the symmetry of curved surfaces and other theoretical concepts known as “pure mathematics.” In 2008, she joined Stanford, where she taught mathematics until her death. French mathematician Cédric Villani called Mirzakhani an “emblematic figure for Iran and for women in science.” “Beautiful mind, beautiful soul, wonderful woman,” he said on Twitter Saturday. Mirzakhani gained international recognition after winning a gold medal in Iran’s International Mathematical Olympiad in 1994. The following year she nailed a perfect score and two gold medals. Like our Facebook page for more conversation and news coverage from the Bay Area and beyond. She went on to college at Sharif University in Tehran and then graduate school at Harvard University, where she was guided by Fields Medal winner Curtis McMullen, who once said she was filled with “fearless ambition.” At Harvard, she was known for her persistence and intense questioning, despite a language barrier. “To see the kind of courage she demonstrated in saying, ‘This is cool stuff, I want to do it and I can do it,’ is just amazing to me,” said Dana Mackenzie, a mathematics and science writer who lives in Santa Cruz. “From the very beginning she’s been a star.” Mirzakhani’s 2004 dissertation, in which she solved two longstanding problems and connected the two into a masterful thesis, catapulted her into even greater fame. It yielded papers in each of the top three mathematics journals. “The majority of mathematicians will never produce something as good,” said Benson Farb, a mathematician at the University of Chicago. “And that’s what she did in her thesis.” Most recently, Mirzakhani collaborated with Alex Askin at the University of Chicago on one of the field’s most perplexing problems: the trajectory of a billiards ball around a polygonal table. The resulting work was hailed as “the beginning of a new era” in mathematics. “It’s a day of mourning for mathematics,” Mackenzie said. “She was one of the brightest mathematicians of her generation, and it’s always just a really sad thing when somebody like that leaves too early.” Reading this on your phone? Stay up to date with our free mobile app. Get it from the Apple app store or the Google Play store. Mirzakhani was a professor at Princeton University and a research fellow at the Clay Mathematics Institute before joining the Stanford faculty. She leaves her husband, Jan Vondrák, and a daughter, Anahita./* * Copyright 2020 ZUP IT SERVICOS EM TECNOLOGIA E INOVACAO SA * * Licensed under the Apache License, Version 2.0 (the "License"); * you may not use this file except in compliance with the License. * You may obtain a copy of the License at * * http://www.apache.org/licenses/LICENSE-2.0 * * Unless required by applicable law or agreed to in writing, software * distributed under the License is distributed on an "AS IS" BASIS, * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. * See the License for the specific language governing permissions and * limitations under the License. / package formula import ( "path/filepath" "runtime" "strings" "github.com/google/uuid" "github.com/ZupIT/ritchie-cli/pkg/api" "github.com/ZupIT/ritchie-cli/pkg/os/osutil" ) const ( ReposDir = "repos" TmpDir = "tmp" DefaultConfig = "config.json" PwdEnv = "CURRENT_PWD" CtxEnv = "CONTEXT" VerboseEnv = "VERBOSE_MODE" BinUnix = "run.sh" BinWindows = "run.bat" BinDir = "bin" EnvPattern = "%s=%s" ) type ( Input struct { Name string `json:"name"` Type string `json:"type"` Default string `json:"default"` Label string `json:"label"` Items []string `json:"items"` Cache Cache `json:"cache"` Condition Condition `json:"condition"` Tutorial string `json:"tutorial"` Required bool `json:"required"` } Cache struct { Active bool `json:"active"` Qty int `json:"qty"` NewLabel string `json:"newLabel"` } Condition struct { Variable string `json:"variable"` Operator string `json:"operator"` Value string `json:"value"` } Create struct { FormulaCmd string `json:"formulaCmd"` Lang string `json:"lang"` WorkspacePath string `json:"workspacePath"` FormulaPath string `json:"formulaPath"` } Config struct { DockerIB string `json:"dockerImageBuilder"` Inputs []Input `json:"inputs"` } // Definition type that represents a Formula Definition struct { Path string RepoName string } Setup struct { Pwd string FormulaPath string BinName string BinPath string TmpDir string Config Config ContainerId string } Help struct { Short string `json:"short"` Long string `json:"long"` } ExecuteData struct { Def Definition InType api.TermInputType RunType RunnerType Verbose bool } ) type Creator interface { Create(cf Create) error } type MakeBuilder interface { Build(formulaPath string) error } type ShellBuilder interface { Build(formulaPath string) error } type BatBuilder interface { Build(formulaPath string) error } type DockerBuilder interface { Build(formulaPath, dockerImg string) error } type LocalBuilder interface { Build(workspacePath, formulaPath string) error } type Wat
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11871, 220, 5225, 163, 105, 234, 44002, 18140, 20622, 43251, 12105, 64, 18, 29533, 22975, 5225, 163, 125, 121, 162, 121, 237, 163, 105, 234, 44002, 64, 37542, 64, 162, 121, 228, 37062, 876, 18, 29533, 22975, 876, 5225, 19, 29533, 22975, 162, 121, 228, 37062, 163, 105, 234, 44002, 64, 4340, 187, 11, 50275, 12755, 236, 17576, 39915, 108, 5225, 48584, 17576, 11871, 220, 163, 105, 234, 44002, 5225, 36750, 17783, 216, 36750, 32378, 18140, 64, 25949, 30329 ]	uceFunction<SensorReading> { public SensorReading reduce(SensorReading r1, SensorReading r2) { return r1.value() > r2.value() ? r2 : r1; } } private static class MyProcessWindowFunction extends ProcessWindowFunction<SensorReading, Tuple2<Long, SensorReading>, String, TimeWindow> { public void process(String key, Context context, Iterable<SensorReading> minReadings, Collector<Tuple2<Long, SensorReading>> out) { SensorReading min = minReadings.iterator().next(); out.collect(new Tuple2<Long, SensorReading>(window.getStart(), min)); } } ``` ``` val input: DataStream[SensorReading] = ... input .keyBy(<key selector>) .timeWindow(<duration>) .reduce( (r1: SensorReading, r2: SensorReading) => { if (r1.value > r2.value) r2 else r1 }, ( key: String, window: TimeWindow, minReadings: Iterable[SensorReading], out: Collector[(Long, SensorReading)] ) => { val min = minReadings.iterator.next() out.collect((window.getStart, min)) } ) ``` #### 使用AggregateFunction进行增量窗口聚合以下示例显示如何将增量`AggregateFunction`与a组合`ProcessWindowFunction`以计算平均值，并同时发出键和窗口以及平均值。 * [Java](#tab_java_10) * [Scala](#tab_scala_10) ``` DataStream<Tuple2<String, Long>> input = ...; input .keyBy(<key selector>) .timeWindow(<duration>) .aggregate(new AverageAggregate(), new MyProcessWindowFunction()); // Function definitions /** * The accumulator is used to keep a running sum and a count. The {@code getResult} method * computes the average. / private static class AverageAggregate implements AggregateFunction<Tuple2<String, Long>, Tuple2<Long, Long>, Double> { @Override public Tuple2<Long, Long> createAccumulator() { return new Tuple2<>(0L, 0L); } @Override public Tuple2<Long, Long> add(Tuple2<String, Long> value, Tuple2<Long, Long> accumulator) { return new Tuple2<>(accumulator.f0 + value.f1, accumulator.f1 + 1L); } @Override public Double getResult(Tuple2<Long, Long> accumulator) { return ((double) accumulator.f0) / accumulator.f1; } @Override public Tuple2<Long, Long> merge(Tuple2<Long, Long> a, Tuple2<Long, Long> b) { return new Tuple2<>(a.f0 + b.f0, a.f1 + b.f1); } } private static class MyProcessWindowFunction extends ProcessWindowFunction<Double, Tuple2<String, Double>, String, TimeWindow> { public void process(String key, Context context, Iterable<Double> averages, Collector<Tuple2<String, Double>> out) { Double average = averages.iterator().next(); out.collect(new Tuple2<>(key, average)); } } ``` ``` val input: DataStream[(String, Long)] = ... input .keyBy(<key selector>) .timeWindow(<duration>) .aggregate(new AverageAggregate(), new MyProcessWindowFunction()) // Function definitions /* * The accumulator is used to keep a running sum and a count. The [getResult] method * computes the average. / class AverageAggregate extends AggregateFunction[(String, Long), (Long, Long), Double] { override def createAccumulator() = (0L, 0L) override def add(value: (String, Long), accumulator: (Long, Long)) = (accumulator._1 + value._2, accumulator._2 + 1L) override def getResult(accumulator: (Long, Long)) = accumulator._1 / accumulator._2 override def merge(a: (Long, Long), b: (Long, Long)) = (a._1 + b._1, a._2 + b._2) } class MyProcessWindowFunction extends ProcessWindowFunction[Double, (String, Double), String, TimeWindow] { def process(key: String, context: Context, averages: Iterable[Double], out: Collector[(String, Double]): () = { val average = averages.iterator.next() out.collect((key, average)) } } ``` #### 使用FoldFunction进行增量窗口聚合以下示例显示如何将增量`FoldFunction`与a组合`ProcessWindowFunction`以提取窗口中的事件数，并返回窗口的键和结束时间。 [Java](#tab_java_11) * [Scala](#tab_scala_11) ``` DataStream<SensorReading> input = ...; input .keyBy(<key selector>) .timeWindow(<duration>) .fold(new Tuple3<String, Long, Integer>("",0L, 0), new MyFoldFunction(), new MyProcessWindowFunction()) // Function definitions private static class MyFoldFunction implements FoldFunction<SensorReading, Tuple3<String, Long, Integer> > { public Tuple3<String, Long, Integer> fold(Tuple3<String, Long, Integer> acc, SensorReading s) { Integer cur = acc.getField(2); acc.setField(cur + 1, 2); return acc; } } private static class MyProcessWindowFunction extends ProcessWindowFunction<Tuple3<String, Long, Integer>, Tuple3<String, Long, Integer>, String, TimeWindow> { public void process(String key, Context context, Iterable<Tuple3<String, Long, Integer>> counts, Collector<Tuple3<String, Long, Integer>> out) { Integer count = counts.iterator().next().getField(2); out.collect(new Tuple3<String, Long, Integer>(key, context.window().getEnd(),count)); } } ``` ``` val input: DataStream[SensorReading] = ... input .keyBy(<key selector>) .timeWindow(<duration>) .fold ( ("", 0L, 0), (acc: (String, Long, Int), r: SensorReading) => { ("", 0L, acc._3 + 1) }, ( key: String, window: TimeWindow, counts: Iterable[(String, Long, Int)], out: Collector[(String, Long, Int)] ) => { val count = counts.iterator.next() out.collect((key, window.getEnd, count._3)) } ) ``` ### 在ProcessWindowFunction中使用每窗口状态除了访问被Keys化状态（如任何丰富的函数可以），a `ProcessWindowFunction`还可以使用被Keys化状态，该被Keys化状态的作用域是函数当前正在处理的窗口。在这种情况下，了解_每个窗口_状态所指的窗口是很重要的。涉及不同的“窗口”： * 指定窗口算子操作时定义的窗口：这可能是_1小时的翻滚窗口_或_滑动__1小时__的2小时滑动窗口_。 * 给定键的已定义窗口的实际实例：_对于
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You may need to get a deep enough container or else it may not fit well into smaller containers. Common opinion holds that this circulator is best suited for medium to large sized containers and nothing smaller. Cost The cost of the Chefman Sous Vide is one of its attractive features. It is available on Amazon for $69.99. This is a great price for technology of this sort. Also, there is a gift wrap option available when you buy it from Amazon. This lets you get it as a gift for a newly married couple or a relative who loves cooking. What are customers saying? Customer reviews indicate that this is a popular sous vide immersion circulator. People who have bought this device like its easy usability and consistent results. Another perk is its very affordable price tag compared to other similar products. This immersion circulator offers all the basic functions as many other more expensive models without having to break the bank. However, there have been some serious complaints about getting defective units in the mail. That said, customer service has been quick to replace broken/ defective items. Some customers feel that the final beeping sound when the food is done is barely audible and they’ve had to use other timers instead. Should you get it? The Chefman immersion circulator is suitable for both beginner and professional sous vide cooks. However, you have to remember that sous vide is a slow cooking method. If you’re okay with waiting and letting your food cook for hours, then this is a good investment. The price, ease-of-use and customer support make it worth the wait. But if you don’t have time to wait for your meals, then you could consider another, faster cooking method. Conclusion The Chefman Sous Vide Immersion Circulator is equipped with all the features that a device of this sort should have. Judging from the positive reviews, we can say that this kitchen appliance is a promising one. Keeping things very simply and easy, the Chefman Sous Vide can really help make any recipe better. If you want to get the same delicious results every time with your cooking, then this immersion circulator is a great investment. As sous vide slowly reaches domestic settings from restaurants, a good precision cooker has become the need of the hour. And as more and more people become familiar with the concept of sous vide cooking, the demand for immersion circulators and sous vide cookers is on the rise. Given this demand, many companies have released their best equipment for this cooking technique. Here, we discuss some of the best precision cookers, in terms of effectiveness and popularity that are in the market at the moment. Here’s a quick look at what each one offers before going into details: Do you want to nail a Thanksgiving turkey or steak in your first attempt? Or perhaps you want to make cooking easier than conventional methods? If you wish to do so, then the Anova Precision cooker is your best friend in the kitchen. The manufacturers claim that the results you get with their device cannot be achieved by any other cooking method. Keeping aesthetics and performance in mind, the manufacturers have put together a sous vide device that is highly stylish yet simple to use. With a fairly simple interface, a highly functional clamp and a precision cooking mechanism, you can’t go wrong with this device. With an 800 Watt motor, the Anova precision cooker circulates water in the container at high speed ensuring that the heat seeps into the food from all sides. This also saves energy and a lot of time that would otherwise be wasted on waiting for the water to heat up to the cooking temp. This cooker has a temperature range of 25 Celsius to 99 Celsius. With its high-precision technology, even a 1 degree difference is noticed by the cooker. Pumping 8 liters of water per minute, this cooker has a pump speed of 1 GMP. Since it comes with a tank, you do not have to invest in your own. The capacity for this tank is 15 to 19 liters which is more than enough for a middle sized family. The Anova makes cooking even more fun for you as it comes with an in-app control feature. You can control and program the device using the app. Just select any recipe from the app and the settings on your cooker will get programmed according to the requirements of that recipe. There is no need to worry even if you are new to sous vide cooking. This is because the Anova comes with an app that has over a 1000 recipes. These sous vide recipes have been formulated and tested by top chefs from around the world. When you start cooking with the Anova Precision cooker, you get cook notifications. This is really helpful for people who need to multi task. You can keep yourself busy with other work while the cooker keeps you notified about the progress of your food. The app has a user-friendly interface, letting you share recipes with your friends. So the next time your guests ask you what recipe you use for your top notch steak, you can share it with them too. Also, there are numerous video tutorials on the app to teach you sous vide cooking. The step by step instructions make cooking so much easier even for beginner level home cooks. The different Anova cookers range from $99 to $150. You can go for the Nano version or the bigger sizes, depending on your needs. It has a rating of 4.3 on Amazon, which means it has satisfied many customers. The Joule Sous Vide cooker is another sous vide machine that is popular among customers. It features a minimalist yet highly elegant design staring with its stainless steel body. The cap and base are both made with stainless steel which makes cleaning very easy. Also, the cold-forged body is resistant to corrosion and will last the test of time because of its durability. As compared to some other immersion circulators, this one is smaller in size which makes it easy to store. Just keep it in the knife compartment or the silverware drawer to save space. The supporting app of this cooker is next-level in its features and ease of use. It has a Visual Doneness feature which lets you see how your food will turn out. This lets you see the final results even before you start cooking. The app also has about a 100 cooking guides that will help you excel at sous vide. These recipes have been devised by the in-house chefs at Chef Steps. Just like the Anova Precision Cooker, this one also has connectivity features. You can connect your phone to the cooker via Wi-Fi or Bluetooth. This makes it really easy to control the settings and check on the doneness of the food even when you are not in the kitchen. Since the immersion circulator comes with a magnetic base, it can be attached anywhere easily. The versatile clip makes it compatible to any pot you have in the house. The Joule Sous Vide immersion circulator is way faster than your everyday circulators out there. It has a wattage of 1100 Watts which heats up water in a matter of seconds while cooking your food at a fast pace too. The settings are easy to program and the temperature settings are precise up to 0.1 F or Celsius. If you have Amazon Alexa at home, then you are in luck because the immersion circulator can also be controlled with your voice because of its Alexa skill. Weighing only 1.3 pounds, this immersion circulator might just be the lightest one in the market. Do not let the size or weight fool you because the strength of this device is matchless in terms of wattage and precision. It is available on Amazon for $199 and has a rating of 4.2 The Sansaire Sous Vide immersion circulator has a smart clip which can be hooked to any heat-resistant pot. Just do that and you are ready to start cooking. The 1000 Watt motor heats the water quickly and propels it so that your food does not stay undercooked. Plus, the 360 circulation feature of this immersion circulator has got you covered ensuring that the water bath stays at a consistent temperature. There won’t be any uneven hot/cold spots in the water bath and your food gets exposed to even temperatures during the entire cooking process. The Sansaire sous vide immersion circulator works with a maximum volume of up to 6 gallons so you can easily feed a party of 8. Weighing 5.9 lbs., this immersion circulator is slightly heavier than other ones on our list. Still, it saves you the cost of expensive vacuum sealing bags as it works just fine with any zip lock or food-grade freeze bag that you may have at home. The LED screen lets you read the temperature and time settings in any light all the way from the kitchen door. The manufacturers have equipped this device with the latest and most innovative thermometer which keeps the temperature in 0.1 degrees of the desired temperature for cooking a meal. This is why the Sansaire immersion circulator is extremely precise, giving you best results every single time. It is a model that is most suitable for cooks who want to keep their cooking simple. Unlike the Anova and Joule immersion circulators, the Sanasire does not have connectivity features. However, that does not take anything away from its performance as an exceptional sous vide device. From salmon fillets to soft-boiled eggs, you can cook everything with this cooker. Made with stainless steel, the cooker will last you a long time since it is corrosion resistant. The body material is also very easy to clean. Just wipe with a damp cloth and you
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253, 1390, 2620, 4289, 1107, 15, 831, 6105, 556, 644, 24028, 264, 625, 2069, 685, 479, 15, 187, 187, 510, 806, 581, 15483, 896, 281, 48190, 5446, 13, 533, 1663, 2210 ]	a transferor is absolved of liability when a prior owner altered an odometer, but not where a third party altered an odometer, even though in either scenario the act took place during the transferor’s ownership. Id. We disagree. {¶ 36} As noted above, the rule is that “the intent of the law-makers is to be sought first of all in the language employed, and if the words be free from ambiguity and doubt, and express plainly, clearly and distinctly, the sense of the law-making body, there is no occasion to resort to other means of interpretation.” Slingluff v. Weaver, 66 Ohio St. 621, 64 N.E. 574, at paragraph two of the syllabus. The language employed in the previous-owner exception is plain and unambiguous. There is no temporal requirement for a transferor to qualify for the previous-owner exception. Such a requirement plainly does not exist in the statute. Therefore, there is no occasion for the court to resort to other means of 9 SUPREME COURT OF OHIO interpretation. This court would invade the province of the legislature and violate separation of powers if it rewrote the statute to include a requirement that the previous owner be the owner of the vehicle at the time of the odometer tampering. See Arbino v. Johnson & Johnson, 116 Ohio St.3d 468, 2007-Ohio-6948, 880 N.E.2d 420, ¶ 21. This court will not engage in such a practice and leaves it to the General Assembly to rewrite the statute if it deems it necessary. {¶ 37} We therefore hold that the previous-owner exception found in R.C. 4549.46(A) applies to a transferor regardless of when a previous owner tampered with the odometer. Conclusion {¶ 38} For the foregoing reasons, we hold that R.C. 4549.46(A) incorporates the odometer disclosure requirements set forth in R.C. 4505.06 and is not a strict-liability statute. Liability can be imposed only if it is established that the defendant knowingly violated the statute. {¶ 39} We further hold that the previous-owner exception found in R.C. 4549.46(A) applies to a transferor regardless of when a previous owner tampered with the odometer. {¶ 40} Accordingly, we reverse the judgment of the court of appeals and remand this matter to the trial court for further proceedings consistent with this court’s opinion. Judgment reversed and cause remanded. MOYER, C.J., and PFEIFER, LUNDBERG STRATTON, O’DONNELL, LANZINGER, and CUPP, JJ., concur. __________________ Richard Cordray, Attorney General, Benjamin C. Mizer, Solicitor General, Stephen P. Carney, Deputy Solicitor, and David M. Dembinski and Teresa A. Heffernan, Assistant Attorneys General, for appellee. 10 January Term, 2009 Carpenter, Lipps & Leland, L.L.P., Michael H. Carpenter, Jeffrey A. Lipps, and Angela M. Paul Whitfield, for appellant. Dreher Tomkies Scheiderer, L.L.P., Darrell L. Dreher, and Vanessa A. Nelson, urging reversal for amici curiae American Financial Services Association and Association of Consumer Vehicle Lessors, National Automobile Dealers Association, and Ohio Automobile Dealers Association. ______________________ 11 Rough Passages: A Guest Post by K.M. Herkes Ever wanted to know more about the first time superpowers appeared in my Rough Passages world? Now’s your chance. Read on… Why is it a reblog? Because Em Ray invited me to take over her blog one day this week. How could I refuse? I love the fascinating and action-packed Rothganar stories (and adore the lovely background tidbits that get posted on Menyoral.com.) So I jumped at the chance to write a guest post. And when I finished writing this one, I thought, “Wow, this world-building stuff was was fun! And useful too!” So I’ve continued doing more posts like it here on dawnrigger.com, and I carried this first inspiration home today. Enjoy! Please welcome the second of my guests, K.M. Herkes, to talk about the world in her Rough Passages stories. 🙂 ~*~ I read the instructions as, “Talk about one of your worlds and worldbuilding. Anything you want to share.” Here’s what came out. Some worlds begin in stardust. They burst forth from a writer’s imagination in a glimmer of dreams and a sparkle of imagination. Mine? Mine start as raw ore, get hammered into shape through force of will and tempered in my sweat. The world of my Rough Passages Tales started with the following raw materials: the angry sound of a slammed door, a photograph of a smoking handprint, and the thought, “Damned hot flashes. I am going to burst into flames, I swear.” The final shining result? A world where a mid-life crisis can cause natural disasters. I twisted history one tiny bit and traced the ripples of consequence forward to a present day…On Sat, 2006-01-07 at 22:09 -0800, Michael A. Peters wrote: > If I were modifying Fedora for desktop users I've been a devoted Fedora/Red Hat user since Red Hat 5.2 because I've found it to be the most mature and well thought out distribution for desktop use. (Well, at least since RH 7.0...) My servers run Debian. Attachment: signature.ascDescription: This is a digitally signed message partQ: Move from MIT license to a new one I want to move from MIT license to a new one, with this goals to reach: Leave the project free to use for individuals and small open source companies Let commercial companies pay some money for using my software And I have some questions about this plan: What license type should I choose? What kind of monetization strategy for commercial use should I choose? One time for company with unlimited use? Each time company uses software in its projects? Will the license have power only for new versions of the software? Or for the old versions too? A: When you are looking for a license which forces some people to pay you but not others, you aren't looking for an open source license. The open source definition says: No Discrimination Against Persons or Groups The license must not discriminate against any person or group of persons. No Discrimination Against Fields of Endeavor The license must not restrict anyone from making use of the program in a specific field of endeavor. For example, it may not restrict the program from being used in a business, or from being used for genetic research. That means we can not help you to find a license which does this, because that would be off-topic on this website. But there might be a way to reach the goal you want while still keeping the project open source: dual licensing. This is a business model used by many open source companies. Offer the software under two different licenses: Gratis under a copyleft license like the GPL For money under a proprietary license In theory, both license models are available to anyone. But the commercial deal should include some additional perks which are important for large companies but secondary for private people and small businesses, like: A support contract A warranty Additional components which are not GPL and help to integrate the software in a business IT infrastructure. Permission to use the software in closed-source applications The exact details of the deal (like pricing structure and whether to charge by use, by user, by cpu or whatever) are a business decision we can not really help you with unless we know your product and your market. Look at your potential customers and ask yourself what kind of deal would be acceptable when you were in their shoes. Also look at competing products and try to offer a slightly better deal than them. Regarding your question about older versions: The older versions are out there under the MIT license. The MIT license has no revocation clause. That means the old versions stay out there under MIT and can still be changed and redistributed. There is not much you can do about it. But you will have a great competitive advantage against them: MIT licensed code can be integrated into GPL projects, but not the other way around. That means when anyone adds any new features or bugfixes to the old MIT version, you can take them and integrate them into the GPL version. But the GPL does not allow the opposite, so they can not integrate your updates into their version (unless they also switch to the GPL). If you've ever prayed to God for protection then don't bother. Visit All Hallows by the Tower and witness the destruction that he's rained upon it over the last five hundred years. This church has been wrecked more times than me. The first one dated back to 675 AD, but really came
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24490, 2275, 290, 78, 17291, 1947, 64, 275, 5112, 347, 795, 69, 5069, 565, 695, 318, 64, 390, 795, 69, 5069, 20172, 64, 285, 275, 4383, 347, 686, 1545 ]	this matters, and we are prepared to affirm its fundamental character. 3. We said at the outset that there was an excess of the One-substance over the one-predicate, and that this is what partly prevented us from assimilating the One to science for example. Consequently such a substitution has not been carried out; it has only resulted occasionally from the nature of certain Hypotheses. The danger resided in the concept of unity, which, as a super-eminent essence, risked receiving properties due more to Platonist metaphysics' [72] valorization of essences than to their reduction to the simplest logical expression. We would thus have harvested, along with the wheat of the One, the One as pure formal term, the chaff of the One as value. This danger must be dissipated. To be sure, each Hypothesis secreted several metaphysical excesses over the amount of logic that it contained, relative to those axioms that we used to frame the beginning of its formulation. But if we take account of the integral and circular character of the matrix, we can consider each excess as due only to the fact that in each Hypothesis, the One can retain or foretell the properties that it receives in another. Step by step, then, the axiomatic matrix as a whole will have reabsorbed the excesses of each particular axiomatic. At bottom, in a given Hypothesis, the One-substance only exceeds the one-predicate by the possible number of predicates it is capable of receiving in all the others. Oddly enough, the dialectical exercise in the _Parmenides_ might reduce [ _réduirait_ ] the essentialist metaphysics by making it circulate in the matrix (whereas in the dialogues without matrix, the ethical or political dialogues, Essence retains on the contrary the splendours and privileges of its solitary valorization). The excess of sense is thereby referred to its true cause, the equivocity of the One due to its distribution across opposed Hypotheses. The One is only substance because it is the support common to all predicates, contradictory or not, that the matrix distributes across it. We will add moreover that Plato mostly limits in each Hypothesis the risks of excess and limits his attention to the case in hand. 4. The result is that in order to manifest this distributive circulation we had to reduce the One to its signifier alone, i.e. to introduce the plane of language. This is to restate here with regard to the general dialectic what was verifiable in each Hypothesis wherever we introduced this plane (with the distinctions that it involves: language-metalanguage, and the ontology it implies: being and the existence of non-real objects), without which the game [ _jeu_ ] of the Hypotheses would have been unplayable. The introduction of language is necessary in order _to save truth through the sacrifice of the thinkable_ , which is the sole duty of the logician. 5. The consideration of these aspects or planes [ _plans_ ] can resolve a last difficulty, one that might arise from interrogating the status of 'our own discourse'. Our self-examination might proceed as follows: To use a matrix of epistemologies is already to prejudge epistemology itself. To which we would respond: no doubt, but in which place of the matrix is this presupposition located? One can refuse the question, and so on to infinity, but it is already useful to know that we can arrange the exercise of the matrix in any of its various cases by a process of _metonymization_ that amounts to substituting, for the language used, the plane of its metalanguage – or again, to replace in the whole of the preceding discussion 'science' by 'epistemology', and 'epistemology' by the matrix exercise itself. And so whoever claims that to refer to a matrix of epistemologies is the mark of a flagrant scepticism will have done nothing more than reposition this exercise as part of Hypothesis VIII. [73] We will thus obtain, by generalizing from this discussion, the following dialectics of epistemologies (we have grouped the Hypotheses in pairs): Hyp. I–V The absolute One = One sole epistemology is true, but which one? Impossible to know (absolute idealism). Hyp. II–IV The participated One = One sole epistemology is true, that which communicates to others by division (dogmatism of participation). Hyp. VI–VIII The participated Non-One = All epistemologies are true, none are privileged (relative scepticism). Hyp. VII–IX The absolute Non-One = None are true (absolute scepticism). And finally Hypothesis III, the mediation of all the others, will be no more than the name of the matrix exercise itself. One will thus choose one's place in the matrix and one will be quite glad (or surprised) to discover neighbours that perhaps one did not know – one's neighbours, which is often to say, one's destiny. But one cannot leave the table. The only bad players are to be found among those who have already been dealt their cards. * * * 1 TN: First published as François Regnault, 'Dialectique d'épistémologies', CpA 9.4 (summer 1968): 45–73. Translated by Knox Peden and Peter Hallward. We should draw attention to some of our translation choices here. Although 'meaning' would often be the more natural translation for _sens_ , we generally translate it as 'sense', in order to serve as a reminder of the double meaning (frequently evoked here) of the French term, as both meaning or signification and as direction or orientation. For the sake of consistency, we have translated all instances of _Un_ or _un_ as 'one' (or occasionally 'oneness'), and all instances of _être_ as 'being'. French allows for the distinction between the infinitive _être_ and the participle _étant_ : the first normally translates as 'being as such' (or as to be), the second as being in the sense of 'a being', or as existing; where necessary we will include _étant_ in brackets. We have translated most of Regnault's references to Plato's _Parmenides_ from the French version he usually refers to (Auguste Diès' edition of Plato, _Parménide_ [Paris: Les Belles Lettres], 1923), but where he refers directly to F.M. Cornford's translation we have followed suit (Francis MacDonald Cornford, _Plato and Parmenides_ [London: Routledge & Kegan Paul, 1939]). We have also drawn on Mary Louise Gill and Paul Ryan's translation of _Plato: Parmenides_ (Indianapolis: Hackett, 1996). Wherever one or both of these translations is used it will be signalled in the notes. 2 The reader can easily skip over the preliminaries that follow and pass directly to the application of the Hypotheses. 3 Jean Cavaillès, _Sur la logique et la théorie de la science_ (Paris: PUF, 1946), 27–28. 4 TN: Cornford, _Plato and Parmenides_ , 104–105. 5 TN: Ibid., 108. 6 TN: The French reads ' _il est impossible de rien penser, si l'on ne pense rien d'un._ ' 7 Aristotle, _Metaphysics_ , book IV, 1001a (citing Jules Tricot's translation of Aristotle, _La Métaphysique_ [Paris: Vrin, 1933/1962], II, 156). TN: W.D. Ross' English translation of this passage (in _The Complete Works Of Aristotle: The Revised Oxford Translation_ , vol. 2, ed. Jonathan Barnes [Princeton: Princeton University Press, 1984]) reads: 'If we do not suppose unity and being to be substances, it follows that none of the other universals is a substance; for these are most universal of all. If there is no unity-itself or being-itself, there will scarcely be in any other case anything apart from what are called the individuals.' 8 On this formalism, see Cornford, _Plato and Parmenides_ , 111ff. 9 Ibid., 112. 10 TN: 'VISITOR: Then let's divide them limb by limb, like a sacrificial animal, since we can't do it into two. For we must always cut into the nearest number so far as we can' (Plato, _Statesman_ , 287 _c_ , trans. C.J. Rowe, in Plato, _Complete Works_ ). 11 This point has been established by Victor Goldschmidt, _Les Dialogues de Platon_ (Paris: PUF, 1947); see in particular sections 1, 6, and 13–16. See also, for Plato's _Meno_ , Alexandre Koyré, _Introduction à la lecture de Platon_ [1945] (Paris: Gallimard, 1962). 12 Cornford, _Plato and Parmenides_ , 111. 13 TN: Laplanche and Pontalis present the Freudian concept of _Triebentmischung_ in French as _désintrication_ or _désunion_ and in English as 'def
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323, 625, 187, 50274, 23454, 670, 2840, 3006, 253, 3879, 15, 535, 50274, 9604, 476, 320, 667, 2238, 273, 10040, 494, 390, 2876, 15, 50276, 2042, 352, 434, 247, 2876, 352, 434, 187, 50274, 46779, 1146, 271, 10040, 494, 342, 581, 5382, 534, 310, 253, 2876, 4817, 15, 187, 50274, 31163, 476, 320, 247, 1618, 273, 11737, 1868, 390, 247, 187, 50274, 27, 2437, 30337, 95, 8358, 76, 2721, 814, 15, 8608, 505, 38124, 15, 31163, 65, 1789, 15, 535, 50274, 22166 ]	._load_form_data() return self.form @cached_property def values(self): """Combined multi dict for :attr:`args` and :attr:`form`.""" args = [] for d in self.args, self.form: if not isinstance(d, MultiDict): d = MultiDict(d) args.append(d) return CombinedMultiDict(args) @cached_property def files(self): """:class:`~werkzeug.datastructures.MultiDict` object containing all uploaded files. Each key in :attr:`files` is the name from the ``<input type="file" name="">``. Each value in :attr:`files` is a Werkzeug :class:`~werkzeug.datastructures.FileStorage` object. Note that :attr:`files` will only contain data if the request method was POST, PUT or PATCH and the ``<form>`` that posted to the request had ``enctype="multipart/form-data"``. It will be empty otherwise. See the :class:`~werkzeug.datastructures.MultiDict` / :class:`~werkzeug.datastructures.FileStorage` documentation for more details about the used data structure. """ self._load_form_data() return self.files @cached_property def cookies(self): """Read only access to the retrieved cookie values as dictionary.""" return parse_cookie(self.environ, self.charset, cls=self.dict_storage_class) @cached_property def headers(self): """The headers from the WSGI environ as immutable :class:`~werkzeug.datastructures.EnvironHeaders`. """ return EnvironHeaders(self.environ) @cached_property def path(self): """Requested path as unicode. This works a bit like the regular path info in the WSGI environment but will always include a leading slash, even if the URL root is accessed. """ path = '/' + (self.environ.get('PATH_INFO') or '').lstrip('/') return _decode_unicode(path, self.url_charset, self.encoding_errors) @cached_property def script_root(self): """The root path of the script without the trailing slash.""" path = (self.environ.get('SCRIPT_NAME') or '').rstrip('/') return _decode_unicode(path, self.url_charset, self.encoding_errors) @cached_property def url(self): """The reconstructed current URL""" return get_current_url(self.environ) @cached_property def base_url(self): """Like :attr:`url` but without the querystring""" return get_current_url(self.environ, strip_querystring=True) @cached_property def url_root(self): """The full URL root (with hostname), this is the application root.""" return get_current_url(self.environ, True) @cached_property def host_url(self): """Just the host with scheme.""" return get_current_url(self.environ, host_only=True) @cached_property def host(self): """Just the host including the port if available.""" return get_host(self.environ) query_string = environ_property('QUERY_STRING', '', read_only=True, doc= '''The URL parameters as raw bytestring.''') method = environ_property('REQUEST_METHOD', 'GET', read_only=True, doc= '''The transmission method. (For example ``'GET'`` or ``'POST'``).''') @cached_property def access_route(self): """If a forwarded header exists this is a list of all ip addresses from the client ip to the last proxy server. """ if 'HTTP_X_FORWARDED_FOR' in self.environ: addr = self.environ['HTTP_X_FORWARDED_FOR'].split(',') return self.list_storage_class([x.strip() for x in addr]) elif 'REMOTE_ADDR' in self.environ: return self.list_storage_class([self.environ['REMOTE_ADDR']]) return self.list_storage_class() @property def remote_addr(self): """The remote address of the client.""" return self.environ.get('REMOTE_ADDR') remote_user = environ_property('REMOTE_USER', doc=''' If the server supports user authentication, and the script is protected, this attribute contains the username the user has authenticated as.''') scheme = environ_property('wsgi.url_scheme', doc=''' URL scheme (http or https). .. versionadded:: 0.7''') is_xhr = property(lambda x: x.environ.get('HTTP_X_REQUESTED_WITH', '') .lower() == 'xmlhttprequest', doc=''' True if the request was triggered via a JavaScript XMLHttpRequest. This only works with libraries that support the `X-Requested-With` header and set it to "XMLHttpRequest". Libraries that do that are prototype, jQuery and Mochikit and probably some more.''') is_secure = property(lambda x: x.environ['wsgi.url_scheme'] == 'https', doc='`True` if the request is secure.') is_multithread = environ_property('wsgi.multithread', doc=''' boolean that is `True` if the application is served by a multithreaded WSGI server.''') is_multiprocess = environ_property('wsgi.multiprocess', doc=''' boolean that is `True` if the application is served by a WSGI server that spawns multiple processes.''') is_run_once = environ_property('wsgi.run_once', doc=''' boolean that is `True` if the application will be executed only once in a process lifetime. This is the case for CGI for example, but it's not guaranteed that the exeuction only happens one time.''') class BaseResponse(object): """Base response class. The most important fact about a response object is that it's a regular WSGI application. It's initialized with a couple of response parameters (headers, body, status code etc.) and will start a valid WSGI response when called with the environ and start response callable. Because it's a WSGI application itself processing usually ends before the actual response is sent to the server. This helps debugging systems because they can catch all the exceptions before responses are started. Here a small example WSGI application that takes advantage of the response objects:: from werkzeug.wrappers import BaseResponse as Response def index(): return Response('Index page') def application(environ, start_response): path = environ.get('PATH_INFO') or '/' if path == '/': response = index() else: response = Response('Not Found', status=404) return response(environ, start_response) Like :class:`BaseRequest` which object is lacking a lot of functionality implemented in mixins. This gives you a better control about the actual API of your response objects, so you can create subclasses and add custom functionality. A full featured response object is available as :class:`Response` which implements a couple of useful mixins. To enforce a new type of already existing responses you can use the :meth:`force_type` method. This is useful if you're working with different subclasses of response objects and you want to post process them with a know interface. Per default the request object will assume all the text data is `utf-8` encoded. Please refer to `the unicode chapter <unicode.txt>`_ for more details about customizing the behavior. Response can be any kind of iterable or string. If it's a string it's considered being an iterable with one item which is the string passed. Headers can be a list of tuples or a :class:`~werkzeug.datastructures.Headers` object. Special
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36575, 15, 7280, 15, 900, 481, 187, 187, 817, 20364, 187, 93, 25474, 50270, 93, 20364, 50269, 93, 187, 93, 15369, 1040, 27, 10428, 27 ]	of "grossly mismanaging the storing, handling, and processing of the complainant's reprisal file." In December 2010, the auditor general criticized Dion's predecessor, Christiane Ouimet, who was found to have retaliated against employees and generally acted inappropriately while in office. David Hutton, executive director of Federal Accountability Initiative for Reform, said Tuesday that Dion "has too much discretion" in the handling of complaints, and "he always uses his discretion to protect the government." Hutton said FAIR was kicked out of the integrity commissioner's advisory board for publicly criticizing the office. He said FAIR is in contact with 50 government whistleblowers, many of whom Hutton said have had negative experiences with Dion's office. Edith Lachapelle, spokeswoman for the integrity office, said the misconduct described in the auditor general's report "is almost impossible to happen again." Lachapelle said the problems with the two files started at the beginning of Dion's mandate and the office has "covered all the bases to assure that these isolated incidents do not happen again."# # Copyright 2020-present Facebook. All Rights Reserved. # # This program file is free software; you can redistribute it and/or modify it # under the terms of the GNU General Public License as published by the # Free Software Foundation; version 2 of the License. # # This program is distributed in the hope that it will be useful, but WITHOUT # ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or # FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License # for more details. # # You should have received a copy of the GNU General Public License # along with this program in a file named COPYING; if not, write to the # Free Software Foundation, Inc., # 51 Franklin Street, Fifth Floor, # Boston, MA 02110-1301 USA # FILESEXTRAPATHS_prepend := "${THISDIR}/files:" SRC_URI += " file://setup-ipmbd.sh \ file://run-ipmbd_0.sh \ file://run-ipmbd_4.sh \ " do_install() { dst="${D}/usr/local/fbpackages/${pkgdir}" bin="${D}/usr/local/bin" install -d $dst install -d $bin install -m 755 ipmbd ${dst}/ipmbd ln -snf ../fbpackages/${pkgdir}/ipmbd ${bin}/ipmbd install -d ${D}${sysconfdir}/init.d install -d ${D}${sysconfdir}/rcS.d install -d ${D}${sysconfdir}/sv install -d ${D}${sysconfdir}/sv/ipmbd_0 install -d ${D}${sysconfdir}/ipmbd_0 install -d ${D}${sysconfdir}/sv/ipmbd_4 install -d ${D}${sysconfdir}/ipmbd_4 install -m 755 setup-ipmbd.sh ${D}${sysconfdir}/init.d/setup-ipmbd.sh install -m 755 run-ipmbd_0.sh ${D}${sysconfdir}/sv/ipmbd_0/run install -m 755 run-ipmbd_4.sh ${D}${sysconfdir}/sv/ipmbd_4/run update-rc.d -r ${D} setup-ipmbd.sh start 65 5 . } FBPACKAGEDIR = "${prefix}/local/fbpackages" FILES_${PN} = "${FBPACKAGEDIR}/ipmbd ${prefix}/local/bin ${sysconfdir} " INHIBIT_PACKAGE_DEBUG_SPLIT = "1" INHIBIT_PACKAGE_STRIP = "1" When using relatively generic search terms like "web" or "SMS" in the iOS App Store, users now receive inline "advertisements" for Apple's built-in equivalents before any third-party apps are shown. Each placard is the same size as a normal app page, but features a different design with fewer elements— the app's icon, a small market blurb about its features, and a direct link to the app or to Apple's website. The interstitials were first noticed by MacStories. A search for "web," for instance, returns Safari's familiar compass logo with accompanying text that prods the reader to "see the web the way it was meant to be seen" and a button that switches to Apple's browser. Using the term "SMS" shows a similar format, but swaps the application button for a "Learn More" link to the Messages marketing page on Apple.com. As noted by MacStories, this is not the first time Apple has manually altered results for specific search terms. Searching for "maps" still brings a link to a listing of alternatives to Apple's built-in navigational aide that was first introduced after the disastrous release of Apple Maps in iOS 6. The App Store search and ranking system is often criticized by developers, and Cupertino's latest move will likely add fuel to that long-burning fire. The company has made several efforts to improve discoverability in the store, most notably acquiring cross-platform app indexing startup Chomp in 2012.Cartoonist Bill Ansell had a heart transplant at Harefield Hospital in 1991. Shortly after his treadmill/exercise test he drew this cartoon. 10 years on and they still use this technique. Only now we have Ann who has added an extra torture, she I am sure puts her hands in the freezer for 10 minutes before touching any patients, especially me. So what do they do to you? First of all they attach ecg stickers to your chest, then check your pulse and blood pressure, then to make you feel really comfortable and at ease, call for a doctor to attend while the test takes place in case they are needed. Now you step on to the treadmill, the ecg leads are attached to the stickers on your chest, the blood pressure arm band is left on your arm, then a clip is put on your nose, and then you have to put a mouth piece in your mouth so that the amount of oxygen you breathe in, and the amount of carbon dioxide you breathe out during the test can be monitored. Ok your under starters orders and we're off, not to bad at first on the flat at a steady pace. Three minutes on and suddenly were going up hill, still not so bad ecg and blood pressure being taken, Ann then with a big smile asks if you are feeling ok, I am sure she is enjoying every minute. Another three minutes even higher and a little faster, now I am being to feel tired, this thing in my mouth isn't helping, nine minutes done and up a little higher. 9 minutes 47 seconds and my calf muscles have had enough and the test is stopped, now Ann is almost laughing she I can tell really does enjoy this part of her job. Apparently I didn't do to bad, Ann then tells me I won't have to do this test again, then just as I begin to relax and smile, she adds with the mouth piece. She really is evil, but for some reason I still like her. I may even buy her a Christmas present (a pair of woolen gloves).# [![angular-translate](https://raw.github.com/angular-translate/angular-translate/canary/identity/logo/angular-translate-alternative/angular-translate_alternative_medium2.png)](http://angular-translate.github.io) [![Greenkeeper badge](https://badges.greenkeeper.io/angular-translate/angular-translate.svg)](https://greenkeeper.io/) ![Bower](https://img.shields.io/bower/v/angular-translate.svg) [![NPM](https://img.shields.io/npm/v/angular-translate.svg)](https://www.npmjs.com/package/angular-translate) [![cdnjs](https://img.shields.io/cdnjs/v/angular-translate.svg)](https://cdnjs.com/libraries/angular-translate) [![Build Status](https://img.shields.io/travis/angular-translate/angular-translate.svg)](https://travis-ci.org/angular-translate/angular-translate) ![License](https://img.shields.io/npm/l/angular-translate.svg) ![Code Climate](https://img.shields.io/codeclimate/github/angular-translate/angular-translate.svg) ![Code Coverage](https://img.shields.io/codeclimate/coverage/github/angular-translate/angular-translate.svg) This is the repository for angular-translate. angular-translate is a JavaScript translation library for AngularJS 1.x app. For more information about the angular-translate project, please visit our [website](https://angular-translate.github.io). ## Status \| Branch \| Status \| \| ------------- \|:-------------:
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]	ICESTRIENSIS. [Another work by this author may be found in some of our public libraries, entitled _Poems on various {132} Subjects and different Occasions, chiefly adapted to Rural Entertainment in the United States of America_. 8vo. 1797. The Preface to this work also gives some account of Searson's residence in Ireland, where, he says, "I lived happily for fifteen years, till another king (or agent) arose, who knew not Joseph, who, in the most inhuman, cruel, and tyrannical manner, made use of his interest to have me put out of my place." The work concludes with the following advertisement respecting himself:--"Being unemployed at present, should any of my kind subscribers know of any vacancy as tutor in some gentleman's family, a place in some public office, genteel compting-house, or vacancy for a schoolmaster, the author will be grateful for the favour of acquainting him of it. He may be heard of by applying to Mr. Mathew Carey, of Market Street, bookseller."] * * * * * Minor Queries. _Haberdon, or Habyrdon._--A manor now belonging to the school at Bury St. Edmund's bears this name. Can any meaning be given to the word? The land formerly belonging to the Abbey of St. Edmund, several registers of that monastery, A.D. 1520 and 1533, let the said manor of Habyrdon, on condition the tenant should yearly find one white bull, &c. The leases all describe this manor of Habyrdon and make it specially necessary to find a white bull. The land is contiguous to the town of Bury, and is called Haberdon at the present time, presents a hilly appearance and remains of ancient intrenchments. I have not heard of any other place by this name. C. G. Paddington. _Holles Family._--I am very desirous of obtaining any information that can be procured concerning the Holles family prior to the time of Sir William, who was Lord Mayor of London in 1540. I should also be obliged if any of your numerous correspondents can inform me, whether that member of the family who married a lady named Gelks, I think since 1700, left any posterity; from whom he was descended, and in what county he lived? Also, who the Gelkses were, and whether the family is represented now; and, if so, of what county they are? The arms of the Holleses were--Ermine, two piles conjoining in the points sable. The crest was a boar's head erased, azure, langued gules, pierced with a pheon. The Gelks bore--Ermine, three chevrons azure, charged with nine bezents inter nine annulets gules. M. T. P. Reading. "_To lie at the Catch_" (Vol. vi., p. 56.).--From accidental circumstances I have only lately seen the notice of my Query. Will you excuse my saying that I do not yet understand the meaning of the phrase "To lie at the catch," and that I shall be greatly obliged if you or any of your correspondents will explain it further, or, in other words, give me a paraphrase that will suit the two passages I have quoted. M. D. _Names of Planets--Spade._--Would any of your correspondents give me some information respecting the _names_ of the different planets of our system, whether their titles are coeval with the apotheosis of the various denizens of Olympus whose names they bear; or whether such names were bestowed upon the heavenly bodies at some later date in honour of those divinities? I should also like to hear explained, how the word _spade_, which from its affinities in other languages would appear to have originally meant _sword_, ever came to be transferred from a weapon of war to the useful and harmless implement it now designates. [Greek: Ouden]. _Arms in painted Glass._--The following arms have recently been found in some decorated windows of the early part of the fourteenth century. Information as to whom belonging would be esteemed a favour. 1. Gules, a chevron, or. 2. Quarterly, first and fourth gules, a mullet, or, second and third sable, a cross, or. 3. Argent, on a chevron, or, three bucks' heads caboshed, tincture indistinct, probably sable. QUAERENS. _The Sign of "The Two Chances."_--An inn, at Clun, in this county, bears the unusual sign of "The Two Chances." What can this mean? Mine host is also Registrar of Births and Deaths for the district. Does it refer to _these two chances_? GEORGE S. MASTER. Welsh-Hampton, Salop. _Consecrators of English Bishops._--It may appear a waste of space to insert in your columns my Queries on this subject, but when you consider that I have been an exile in India for the last eleven years, and consequently unable to refer, in this country, to authorities, which are easily accessible at home, I venture to hope that you will not only give a place to this, but also that you, or some clerical reader of "N. & Q.," will afford me the required information. I have continued Mr. Perceval's list of English consecrations, given in his able work, _An Apology for the Doctrine of Apostolical Succession_, 2nd edition of 1841, but have been unable to complete it with the names of the consecrators of the following prelates, the objects of my Query; viz. 1. Bishop Gilbert, of Chichester, on 27th February, 1842; 2. Bishop Field, of Newfoundland, 28th April, 1844; 3, 4, & 5. Bishops Turton of Ely, Medley of Fredericton, and Chapman of {133} Colombo, on 4th May, 1845; 6. Bishop Gobat, 5th July, 1846; 7 & 8. Bishops Smith of Victoria, and Anderson of Rupert's Land, on 29th May, 1849; 9. Bishop Fulford of Montreal, 25th July, 1850; and 10. Bishop Harding of Bombay, on 12th August, 1851. The dates are, I believe, correct, but if not, of course I should like the mistakes to be pointed out. I also desiderate the date of Bishop Binney's (of Nova Scotia) consecration, in March or April, 1851, with names of his consecrators; and finally, the place of Bishop Lonsdale's (of Lichfield) consecration, on 3rd December, 1843. If these data are supplied, the lacunae in my supplemental list of English consecrations, from the Reformation to the present day, will be complete. A. S. A. Punjaub. _A nunting Table._--What is it? The word occurs in a quotation from Dr. Newman in the _Irish Ecclesiastical Journal_ for December, 1852, describing a modern English church. I suppose I shall be snubbed for not giving the passage; but my copy of the journal has vanished. A. A. D. _John Pictones._--Is anything known of John Pictones, or Pyctones, a person mentioned in a MS. as having taught languages to Queen Elizabeth when she was young? C. R. M. _Gospel Place._--In a definition of the boundaries of Bordesley Abbey, dated 1645, given in Nash's _Worcestershire_, there frequently occurs the term "Gospel place," thus: "And so to a Cross or Gospel Place near to Brown's cottage, and from thence to a Gospel Place under a tree near to a mill ... thence to the old Gospel Place oak that standeth on the common." I have heard that at each one of these "Gospel places" there was kept up a mound on which it was usual to rest a corpse on its way to the churchyard, during which time some portion of the gospel was read. Can any of your correspondents say if such a practice was observed in any other part of the country, its origin, its intention, and the period of its discontinuance? And if not, can give any other explanation of the term? G. R. _York Mint._--Can any of your correspondents inform me of the names of the officers
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3034, 11046, 689, 247, 4289, 14, 8938, 5926, 15, 1707, 697, 2553, 3531, 247, 1095, 69, 1070, 14370, 13, 285, 253, 6032, 1255, 273, 253, 5170, 6749, 3395, 23982, 1520, 715, 1424, 87, 30131, 285, 8336, 15, 309, 812, 923, 1289, 12784, 398, 273, 4797, 6749, 2080, 1066, 3304, 253, 2133, 273, 253, 37116, 1321, 15, 2064, 369, 835 ]	devoted an entire treatise – _Creation and Its Mysteries Revealed_ – to showing how the continents had once been united. But in the mid-nineteenth century there was simply no context for such a radical overhaul of geological theory; no other pieces of knowledge with which the theory itself could fit. A mainstay of nineteenth-century geology was a belief in the existence of enormous land-bridges which had at one point joined the world's continents, but had since then crumbled into the oceans. These land-bridges explained the existence of the same species on different landmasses, and seemed far more plausible than mobile continents. In 1912, therefore, Wegener was arguing against the grain of prevailing wisdom: if his theory were correct, it would nullify many of the founding assumptions of nineteenth-century geology. Worse still, Wegener was an intruder, a trespasser on the turf of the geologists. For his main field of research was meteorology – he was a pioneer in weather-balloon study and a specialist in Greenland, where he led several successful, and one fatal, Arctic research expeditions. How could a weatherman presume to dismantle at a single stroke the complex and magnificent edifice of nineteenth-century geology? The opposition to Wegener's theory, as to that of Burnet so many years earlier, was immediate and voluble ('Utter, damned rot!', said the president of the American Philosophical Society, eloquently). But Wegener, a stoic visionary, remained phlegmatic in the face of early antagonism. In 1915 he published _The Origins of Continents and Oceans_ , a careful explanation of his theory, and in its way as apocalyptic a reimagining of the earth's history as Burnet's _The Sacred Theory of the Earth_ or Hutton's _The Theory of the Earth_. Between 1915 and 1929 Wegener revised his _Origin_ three times to take into account advances in geology, but he was still ignored by the geological establishment. In 1930 he led another meteorological expedition to Greenland. Three days after his fiftieth birthday he and his team were caught in a severe Arctic blizzard, in which temperatures dropped to −60°F. Wegener became separated from his companions, and froze to death in the private wilderness of a white-out. His body was found by his colleagues when the storm receded. They entombed Wegener inside a mausoleum built of blocks of ice, topped with a twenty-foot iron cross. Within a year, the structure and its contents had disappeared into the interior of the glacier on which it was built – a means of burial that would no doubt have met with Wegener's approval. It was not until the advent of the so-called New Geology during the 1960s that it was realized that Wegener had been at least half-right. As advances in bathysphere technology permitted the more systematized exploration of the ocean floor, it was discovered that the continents did indeed move and had indeed spun apart from a vast ur-continent. But the continents weren't – as Wegener had thought – independent entities drifting over a sea of basalt, like icebergs in water. In fact, the surface of the globe was discovered to be composed of some twenty crustal segments or plates. The continents were simply the portions of the plates which were sufficiently elevated to protrude from the sea. These plates were named by the New Geologists. There was the African Plate, the Cocos Plate, the North American Plate, the Nazca Plate, the Iran Plate, the Antarctic Plate, the Juan de Fuca Plate, the Australian Plate, the Arabian Plate and the decidedly unfragile China Plates. Driven by convection currents or 'cells' within the semi-liquid mantle of the earth, and pulled by their own weight, these plates move around relative to each other. Where their edges meet beneath the ocean, either a mid-ocean ridge or a subduction zone is formed. At mid-ocean ridges the boundaries of two plates are continually being pushed apart by action in the mantle. Magma rises into the gap, and cools to form sea-floor basalt. Mid-ocean ridges are therefore raised above the surrounding ocean floor, like the seam on a cricket ball. A subduction zone, by contrast, is where the edges of two plates are forced together, and the less buoyant plate slides underneath the other. There, the rock of the subordinate plate is pushed down into the mantle, where it melts and comes bubbling back up in liquid form, causing super-heated wounds in the crust. These subduction zones form the oceanic trenches: the Aleutian Trench, the Java Trench, the Marianas Trench. At the bottom of these trenches – the Marianas Trench is deeper than Mount Everest is high – the atmospheric pressure is so enormous that, were you to materialize at that depth, your body would instantly be compacted to the size of a tin can. Most of the world's mountain ranges have been thrown up by the jostling and collision of the continental plates. Thus, for example, the Alps were created when the Adriatic Plate (which carries Italy on its back) was driven into the Eurasian Plate. The oldest mountains are those which are now the lowest, for erosion has had time to reduce them. The blunted, rubbed-down spine of the Urals, for instance, speaks of great age. So too do the rounded forms of the Scottish Cairngorms. Perhaps surprisingly, among the youngest mountains on earth are the Himalaya, which began to form only 65 million years ago, when the Indian Plate motored northwards and smashed slowly into the Eurasian Plate – ducking underneath it and then butting it five-and-a-half miles upwards into the air. Compared to the earth's venerable ranges, the Himalaya are adolescents, with sharp, punkish ridges instead of the bald and worn-down pates of older ranges. Like adolescents, too, they are still growing. Everest – which became the world's highest mountain less than 200,000 years ago – shoots up by a precocious five millimetres or so a year. Give it a million years – the blink of an eye in geological terms – and the mountain could have almost doubled its height. Except of course that won't happen, because gravity won't tolerate such a structure. Something will give: the mountain will collapse under its own weight, or be shaken apart by one of the huge earthquakes which rack the Himalaya every few centuries. For years now I have gone to the mountains and been astonished by deep time. Once, halfway up the mica-rich peak of Ben Lawers in Scotland on a sunlit day, I found a square chest of sedimentary rock, hinged at its back with an overgrowth of moss and grass. Stepping back and looking at it from the side, I could see it was composed of hundreds of thin layers of grey rock, each one no thicker than a sheet. Each layer, I reckoned, was a paraphrase of 10,000 years – a hundred centuries abbreviated into three millimetres' depth of rock. Between two of the grey layers I noticed a thin silvery stratum. I pushed the adze of my walking axe into the rock, and tried to lever the strata apart. The block cracked open, and I managed to get my fingers beneath the heavy top lid of rock. I lifted, and the rock opened. And there, between two layers of grey rock, was a square yard of silver mica, seething brightly in the sunlight – probably the first sunlight to strike it in millions of years. It was like opening up a chest filled to the brim with silver, like opening a book to find a mirror leafed inside it, or like opening a trapdoor to reveal a vault of time so dizzyingly deep that I might have fallen head-first into it. * Although, as Simon Winchester has recently pointed out, a 1991 poll returned that 100 million Americans believed God to have created man in his own image sometime in the last 10,000 years. The earth is thought by science to be around 5 billion years old; the first humans to have appeared _circa_ 2 million years ago. * Geology remained a driving force in mountaineering until well into the twentieth century – the first three Everest expeditions (1921, 1922 and 1924) were funded in part as scientific expeditions aimed at bringing back geological (and botanical) knowledge of the Everest region. # 3 The Pursuit of Fear That Alpine witchery still onward lures, Upwards, still upwards, till the fatal list Grows longer of the early mourned and missed. FRANCES RIDLEY HAVERGAL, 1884 I looked upwards. A tall, steep face of rock, striped vertically with snow gullies, angled up into the lightening sky. That was our route. My eye followed the face down. Without relenting in angle, it dropped some 600 feet to a small glacier which arced off the bottom of the face. The convex surface of the glacier looked hard, silvered and pitted like old metal, and it was pocked with stones which had fallen from the cliffs above. Further down, the glacier tumbled over a hundred-foot drop. There its surface turned a curdled grey, and the smoothness of the upper ice became ruptured into crevasses and blocks. I could see glimmers of blue ice far down inside the body of the glacier. That was where
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That includes more than 240 redactions from the first volume of the report alone. Howell gave DOJ until Wednesday, Oct. 30, to comply. A Justice Department spokeswoman did not immediately respond to a request for comment. The White House and congressional Republicans have argued that the Democrats' impeachment inquiry, which has expanded to include a probe into whether Trump pressured Ukraine into investigating former Vice President Biden and his son, is illegitimate because it hasn't been authorized by a vote in the House. The DOJ echoed that argument to the district court last month, writing in a filing that “impeachments of Presidents Clinton and Andrew Johnson were investigated in multiple phases with each phase authorized by the House’s adoption of resolutions.” Howell rejected the Justice Department's assertion in her opinion Friday. "Even were this statement accurate, which it is not, the manner in which the House has chosen to conduct impeachment inquiries encompasses more than past Presidents and no sound legal or constitutional reason has been presented to distinguish the House’s exercise of impeachment authority for a President from the exercise of such authority more generally," Howell wrote. The House Judiciary subpoena is part of a legal battle being fought on several fronts between the Trump administration and House Democrats investigating the president. The committee applied for a court order for the grand jury materials in July in order to continue Mueller's probe into Russian interference and possible obstruction of justice by the White House. "Because Department of Justice policies will not allow prosecution of the sitting president, the United States House of Representatives is the only institution of the federal government that can now vote President Trump accountable for these actions,” Rep. Jerrold Nadler Jerrold (Jerry) Lewis NadlerDemocrats shoot down talk of expanding Supreme Court Schumer: 'Nothing is off the table' if GOP moves forward with Ginsburg replacement Top Democrats call for DOJ watchdog to probe Barr over possible 2020 election influence MORE (D-N.Y.), the chairman of the Judiciary Committee, said in a press conference at the time. Nadler said on Friday that he's gratified by the court victory. “The court’s thoughtful ruling recognizes that our impeachment inquiry fully comports with the Constitution and thoroughly rejects the spurious White House claims to the contrary," he said in a statement. "This grand jury information that the Administration has tried to block the House from seeing will be critical to our work.” Trump has also been fighting efforts to obtain his tax returns, other financial records and documents related to his Washington hotel. The president has shown no willingness to compromise on any of the document requests. This week, following an appeals court ruling uphold the House Oversight and Reform Committee's subpoena of the president's accounting firm, Trump's lawyers said they intended to take the case to the Supreme Court. Also this week, in another case that seems destined for the nation's highest court, Trump's personal lawyers doubled down on their assertion that the president is immune from criminal investigation and prosecution while in office — a view that has been endorsed by DOJ. Howell on Friday noted in her opinion that theory of blanket immunity for the president "has never been adopted, sanctioned, or in any way approved by a court." Updated at 5:24 p.m. Order Redacted Mueller Mate... by M Mali on ScribdReuters) - Dutch bioscience company Pantarhei intends to bid for the bulk of U.S. company Merck's (MRK.N) Netherlands-based bioscience research unit Organan, the Dutch Financieele Dagblad reported on Monday.Gavce Gavce (, sometimes misspelled Gavče) is a settlement in the Municipality of Šmartno ob Paki in northern Slovenia. It lies on the left bank of the Paka River north of Šmartno. Traditionally the area was part of the Styria region. The municipality is now included in the Savinja Statistical Region. A small chapel-shrine in the settlement containing a statute of Saint Urban dates to the mid-19th century. References External links Gavce at Geopedia Category:Populated places in the Municipality of Šmartno ob PakiFund seeks to help counties pay bills, fight opioid abuse COLUMBUS >> A veteran Ohio politician called on Wednesday for the creation of a special state fund to help counties boost employment, fight opioid abuse and cover basic expenses. Any of the state’s 88 counties, large or small, would be eligible to draw from the equalization fund proposed Wednesday by Republican Gene Krebs. The former state representative is a farmer and public policy expert from Preble County who’s running for state Senate. Krebs said Ohio originally created county governments to implement the state’s policies and laws, but those without ample retail businesses subject to sales taxes have little way to raise the funds they need in the wake of local government fund cuts. “In short, counties themselves were the original unfunded mandate,” he said. “But due to changes in shopping and lifestyle, many are now unable to fully locally fund their duties.” Advertisement Krebs cited a recent study by the Cleveland-based Center for Community Solutions that found: • 16 percent of working-age adults in small rural towns are disabled, a higher proportion than in big cities or the state as a whole. • 15 percent of those 25 or older in small rural towns hold college degrees, compared to 25 percent in big cities and the state as a whole. • 34 percent of children in small rural towns live in poverty, compared to 23 percent statewide. • 75 percent of school-aged children in small rural towns participate in the federal school lunch program for those below or near poverty, exceeding the statewide rate by more than 25 percent. Krebs said his proposed fund is aimed at beginning to reverse this problem by “equalizing” county revenue based on where residents shop. A county whose residents shop and dine elsewhere would have a greater chance for access to the fund, while a county with a large outlet mall drawing many out-of-county shoppers would have less opportunity. “This is not Robin Hood. We are not proposing to reduce the piggyback sales tax revenue from the rich counties and give to the poor,” he said. “This is also not county welfare. It is meant to help them get back up on their feet.” State funds used to develop the equalization fund could be tapped for one of only three purposes: to combat the opioid and heroin epidemic, for economic development programs that increase sales-tax revenue and workforce development, or to cover general county expenses. The fund is designed to expire after 10 years, with interim assessments built in to see how the plan is doing. Krebs said the state Department of Taxation would prepare new charts annually for disbursement of the money and the fund would be subject to regular state audits.In some cases, pirates get away with the act by exploiting how stores like Amazon manage inventory. They'll let third parties lump their stock in with those of official partners (right down to similar barcodes), making it relatively easy to slip bogus products through the cracks. The RIAA says Amazon was eager to help tackle pirated material after learning of the findings, and Amazon itself says it's "working closely" with both distributors and labels to clamp down on counterfeiters. There's certainly some urgency to improve anti-piracy efforts. Although downloads and streaming thrive in North America, CDs make up just shy of 40 percent of worldwide music industry revenue. Publishers can't count on digital sources to pick up all the financial slack, especially in regions where CDs are either relatively popular (such as Europe) or the only realistic way to listen. Until broadband is both ubiquitous and genuinely affordable for a large chunk of the world, CD piracy is bound to be tempting.The Shirt A basic Latin/Rhythm shirt is usually a long sleeved black or white shirt without patterning or reflective materials. Shirts are often opened to mid-chest or lower, or turtle necked. These shirts aren't really shirts, but leotards. They strap around between the legs, or have built in shorts, so that the shirt doesn't become untucked while dancing. You can always wear a regular dress shirt, but it is likely to become untucked during dancing, and the shoulders will often look scrunched up, distorting your frame. If you don't want to spend the money, you can wear an Under Armour shirt instead, since Latin shirts are expensive. Most shirts cost around $150, but high end custom made shirts can cost as much as $400. Latin/Rhythm pants are solid black pants, sometimes with a satin stripe down the outside of the leg or a satin waistline. They differ from Standard/Smooth pants in that they are tighter at the thighs, but flare out to be wider at the lower legs. They also usually have a sewed in seem down the front to make them look recently ironed. Sometimes they have an elastic band that wraps around the foot so the pants don't slide up and expose the leg during dancing. There is no difference between the pants generally worn by beginners and those worn by advanced dancers. Latin pants start out at around $80 and can cost as much as $400 for a high end custom made pair. Basic Standard/Smooth Shirt Most beginners don't want to spend thousands of dollars on a tail suit, and many prefer a basic Standard shirt. If you aren't wearing tails, you must wear a white dress shirt. It can have any kind of collar and cuffs, but it must be
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747, 18825, 34759, 327, 253, 3216, 285, 253, 3198, 273, 1097, 7123, 15, 187, 187, 1552, 310, 9093, 3968, 7004, 253, 41228, 292, 281, 18883, 9676, 13389, 10858, 2425 ]	, and the extent of Palestinian frustration. The latter could be more fueled by a Palestinian retreat from U.N. action and a return to meaningless negotiations or by a failure at the U.N. to overwhelmingly endorse Palestinian rights than by a successful, symbolic win at the U.N., even if that does not translate the morning after into new freedoms on the ground. Having said all of this, there are ways in which a U.N. resolution could be constructive and help achieve progress toward a better future for both Palestinians and Israelis (of course these prospects will partly depend on the exact wording and nature of any specific resolution). For instance, a U.N. resolution clarifying that a two-state solution would be on the 1967 lines (allowing for modifications to that line only on the basis of agreed, equal, and minor land exchanges) with Jerusalem serving as the capital of both states, could help ground any future negotiations in more realistic terms, establishing that the contours of a two-state arrangement cannot be endlessly flexible while also undermining the time-wasting and obfuscatory special pleading that tends to characterize Israeli negotiation tactics. At the same time, such a resolution would powerfully entrench the two-state solution, guaranteeing a future for both Israel and a Palestinian state. That is the main reason that those preferring a one-state outcome -- from both the more absolutist Palestinian rights camp and from the Greater Israel settler camp -- are opposed to this U.N. move. This should provide a reason for the pro-democracy wing of the pro-Israel camp to attempt to work constructively in this U.N. space. Yet most of the American Jewish establishment groups who by self-definition claim to support a democratic Israel seem more busy taking a victory lap every time another Eastern European or Pacific Island state declares itself against the U.N. vote. In Israeli domestic political terms a strongly endorsed U.N. resolution would administer a kick to the groin of the peace rejectionist policies pursued by the current Netanyahu-Lieberman government. It is hard to see how peace is advanced by rewarding those rejectionist policies, whether at the U.N. or in the constructing of Quartet statement language. For the Palestinians, a U.N. resolution that upgrades their U.N. status to non-member state (similar to the Vatican status), would pave the way to membership in additional institutions including very likely the ability to take cases to the International Criminal Court (ICC). While the asymmetry of Israeli-Palestinian realities and therefore the logic of the Palestinians gaining leverage by utilizing non-violent diplomatic tools of this nature is a powerful one, this is not something that the Palestinian leadership is claiming it will pursue subsequent to any U.N. vote. Given both the legitimacy of the U.N. as a venue for advancing Israeli-Palestinian conflict resolution and this non-exhaustive list of potential benefits that could be derived from such a move, why is it that the U.S. (and in many ways Europe) are so uncomfortable about a U.N. vote and working so hard to prevent it from occurring? The respective reasons for American and European opposition are not exactly the same. Both share a preference to be on the same page when it comes to this issue and it is unlikely that would happen should it come to a U.N. vote. When the Security Council voted on a settlements resolution in February, the EU states supported the resolution while the U.S. was alone in opposing and vetoing it. The U.S. and Europe also share a concern that the U.N. route would signal the beginning of them losing control of this issue (a worry that is more acute for the U.S.). And even if the Palestinians are not planning to go to the ICC or to try to sanction Israel in various ways subsequent to a U.N. vote, that might be the future trajectory for this conflict and a U.N. vote might ultimately encourage that, which is likely to present a series of difficult decisions down the road (in this case especially for the Europeans). The main explanation for U.S. opposition to any U.N. consideration of a Palestine resolution would appear to be rooted in the domestic politics of this issue. With re-election coming up (isn't it always) the president would be unenthusiastic about having to deal with the background noise criticism that many of the so-called pro-Israel lobbying groups would undoubtedly generate in the wake of any U.N. vote. Even a U.S. veto in the Security Council or "no" vote in the General Assembly would not shield the president from being attacked. He will be blamed for encouraging the Palestinians to try this path by stating in his speech last year to the UNGA that "when we come back here next year, we can have an agreement that will lead to a new member of the United Nations -- an independent, sovereign state of Palestine." The president is also likely to be held accountable for failing to sufficiently persuade or pressure any state with whom American maintains bilateral relations and that votes with the Palestinians. Yes, it is ridiculous. Republican congressional leaders have threatened to withhold America's UN payments if such a vote goes ahead, giving the president another horse-trading headache in the already difficult act of managing congressional relations. What's more, members of Congress from both parties are threatening to de-fund all U.S. assistance to the Palestinian Authority if the Palestinians push a U.N. vote. This matters because administration officials understand that de-funding might not only encourage escalation on the ground, but it also removes an important lever of U.S. influence with the Palestinians for managing the conflict in ways that are convenient to Israel. A classically ironic own goal for the pro-Israel community, this one. There is also the small matter of America's own national interests and credibility at the U.N., in the Middle East, and in the broader global community. If there is a U.N. vote and domestic politics dictates a US "no" vote, then while no direct causal line can be drawn between that vote and increased extremist recruitment, terror, and threats against the U.S.,the relationship between those factors is nonetheless one that American leaders and especially military leaders are all too aware of. The distinctly European reasons for also preferring that a U.N. move be avoided mainly revolve around the difficulty that exists in producing a common European position and in the absence of such a position the inability to bring leverage to bear and the exposing of divisions within Europe. Given the shared point of departure on the desirability of producing an alternative to the Palestinian push at the UN it might seem somewhat surprising that the U.S., Europe, and the rest of the Quartet failed to produce a common statement at last week's high level meeting. Surprising, that is, until one considers what was on offer from the U.S. -- which is where the American sophistry comes in. The U.S. presented to its Quartet "partners" a suggested one page text that looked rather like an exercise in cherry picking Obama's recent speeches by the Israeli Prime Minister's office (given the recent traffic between Jerusalem and Washington and the end product it is reasonable to speculate that that is precisely what happened). The American pitch went something like the following: the proposed text is a reflection of the President's speech, the Quartet had encouraged the President to give such a speech, the President had taken some political heat for the speech, the Quartet had even endorsed the speech (which it did in a May 20 statement), therefore the Quartet should now stand united behind the American draft, demonstrate to the Palestinians that they have no alternative but to accept the Quartet position, resume negotiations, and drop the U.N. idea. The text was quite clearly pre-cooked with the Israeli leadership, so no problem of acceptance from Israel. Except that the U.S. text was not a faithful rendition of what the Quartet had endorsed -- namely, the May 19 State Department speech of the president -- but rather a hodgepodge of language from that speech, from the May 22 speech at the AIPAC conference, and of elements never before endorsed by the Quartet and even contradicting the existing positions of the EU and others. Hence the stalemate -- and not altogether a shock given Jerusalem's apparent co-authorship of the text. So here are the details. To recap: President Obama's May 19 speech spent 1,040 words addressing the Israeli-Palestinian conflict. Obama described the conflict, touched on Israeli and Palestinian aspirations, and made a case for a solution being more urgent than ever in the context of the Arab awakening. The President then made news when, in calling for a resumption of negotiations, he stated that "the basis of those negotiations is clear," and then spent 170 words providing the parameters of a borders and security first approach to achieving two-states (his reference of the 1967 lines in particular drew attention). He closed out this part of the speech by saying "these principles provide a foundation for negotiations." The U.S. draft proposal presented to the Quartet did include the President's language from the May 19 speech, but it also included a whole lot more, all of it skewing, extremely uni-directionally, in Israel's favor. To the simple May 19 border language of "based on the 1967 lines with mutually agreed swaps," the U.S. added the following from the May 22 speech: “The parties themselves will negotiate a border between Israel and Palestine that is different than the one that existed on June 4, 1967, to take account of changes that have taken place over the last 44 years, including the new demographic realities on the ground and the needs of both sides. This is essentially America asking the Quartet to endorse illegal Israeli settlement activity
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6684, 13746, 285, 10777, 1632, 342, 12696, 326, 403, 1335, 1663, 12482, 285, 1663, 17319, 13, 533, 671, 1039, 1679, 11742, 13, 285, 13, 973, 1663, 1524, 15, 187, 187, 1992, 1978, 1841, 432, 1146, 581, 3877, 13, 309, 3078, 281, 1973, 13746, 342, 247, 1643, 2969 ]	induced significant (p < 0.05) elevations in cardiac tissue concentrations of nitric oxide and malondialdehyde as well as serum levels of cardiac injury biomarkers (lactate dehydrogenase, creatine kinase, and creatine kinase-MB) and proinflammatory cytokines (interleukin-1β, and tumor necrosis factor-alpha). The histopathological examination showed necrotic and degenerative changes in the cardiac tissue, while immunohistochemical analysis revealed marked myocardial expression of activated caspase-3 and cyclooxygenase-2, following DOX adminstration. Allicin pretreatment significantly improved (p < 0.05) all examined parameters, and restored the cardiac architecture. The current study demonstrated that allicin effectively mitigates cardiac oxidative damage, apoptosis and inflammation, induced by acute DOX intoxication. Therefore, allicin could be a promising cytoprotective agent against DOX cardiotoxicity.Seven years after the last Harry Potter sets were released, LEGO has unveiled a number of exciting new Harry Potter and Fantastic Beasts themed builds. The centrepiece of the new products is an epic 6000+ piece (!) Hogwarts Castle and grounds. The new sets feature iconic scenes from the 8 ‘Potter’ films, as well as two Fantastic Beasts and Where to Find Them sets (including an exciting new Crimes of Grindelwald build). A number of new minifigures are also included with the new releases. The new sets include Aragog’s Lair, the Whomping Willow and castle, The Great Hall, the Hogwarts Express and a Quidditch Match. The Fantastic Beasts sets include Newt’s Case (complete with a number of magical creatures) and Grindelwald’s Escape (in what looks to be a Thestral-and-cart), a new scene we’ll learn more about in the Crimes of Grindelwald film. The epic highlight of the new sets is a 6020-piece Hogwarts Castle, LEGO’s second largest set (behind the Star Wars Millenium Falcon). The castle showcases a number of iconic scenes from the ‘Potter’ films, and includes 4 minifgures (the four Hogwarts founders) and 27 character microfigures.Don’t Worry (or Celebrate?) Rick Santorum will Not be the Next President, by Lawrence Spaulding …even if he wins the Iowa caucuses or comes in second, or third. And Ron Paul won’t be the next president if he wins either. Really. The importance of Iowa is not that it picks the winner, just ask President Pat Robertson or President Mike Huckabee, instead it helps identify the losers (or more gently it “winnows the field.”) Iowa is not about delegates, only a few are at stake, so don’t be distracted by that tally. Instead it can reveal and effect who can keep raising money and who can’t, as well as who has the capacity for campaign organization and who doesn’t. If Michele Bachmann can’t land in the top 3-4 in her neighboring state and where she has been campaigning for the greater part of a year, can she do better in Florida? In South Carolina? If a fire breathing social conservative like Rick Perry can’t end up in the upper tier in Iowa, can he perform well in New Hampshire or Florida? If Newt Gingrich floats like a stone in Iowa, where can he do better? These candidacies may limp on for a few more weeks hoping for an implosion elsewhere in the field. So, is the nomination Romney’s? If yes, it is not because he wins delegates in Iowa or comes out on top in the polls; but showing well in Iowa makes it more difficult for others to close the gap, narrow as it is. He can keep chugging along, slowly gobbling up more and more endorsements and raising more and more money even if he generates little enthusiasm. He can stub his toe here and there, and still do fine so long as doesn’t actually stumble and fall in a way he has shown no inclination to so far. The question for Republicans is what makes their eventual candidate the strongest against President Obama. A bruising nomination fight can certainly hurt and show a candidates’ vulnerability. On the other hand, a hard fought primary season can strengthen a candidate. Senator Obama may have become President Obama even without the hard fought primary battle with Senate Clinton, but it is hard to doubt that those contests made him a much stronger candidate. Mitt Romney has shown himself to be an aggressive, well-disciplined, well organized candidate, but so far the pre-primary period has not shown if he can take a punch. Iowa won’t reveal that neither will New Hampshire. And if not then, it might be fall before we find out. – Lawrence Spaulding Also: Googling ‘Santorum’ Leads to Nationwide EwwwwsSaturday, June 28, 2008 We do more than we think and Sat. Habit I think as moms that we think we dont do much if all the house isnt neat and tidy 24 -7. I have decided we all do more than we think !!!!Yesterday when Angel wanted to go swimming I had to vaccum the pool which wasnt on the list but what about the other things. I mean we make meals and then pick up without realizing it and finally we are responsible for waking the children, tending to their needs or wants all day , driving them places , making snacks, getting them ready for bed , finally tucking them in. I think with all these responsibilities we need to be easier on ourselves. It made me wake up and realize this especially because now I am also activity organizer for the summer and chauffeur too. All the hats we wear doctor, nurse, cook, housecleaner, activity director, chauffeur, hairdresser, personal dresser and finally mommy which encompasses it all.( I am sure I missed a few) Today I started on my backyard by scrubbing down the plastic chairs with the wonderful Mr.Clean sponge and wiping down the table too . I will need to go out and buy some plastic tablecloths for my two tables sometime this week. So for my Sat. habits I was looking around today and noticed there were many spots that dont get cleaned on a regular basis and I want to change that. The spots I was looking at were window sills, doors, windows, baseboards, and door frames. My habit is going to make sure I do at least one of these in a room each day so by the end of the summer it will be all done.Today I wiped down the front door, the framing around our mirror closet door, windexed the front door too. It looks so much better and makes me feel good too to get rid of a lot of dirt.I am going to start working on Anthea Turners book " The Perfect Housewife" so I dont miss anything in each room. I will add to her lists in each room if I have anything to add.I also am going to try three new recipes this week. Maybe by the end of summer I will be doing the menu planning for the week. I want to try and have some homemade baking done every week too.So this weeks will be banana bread.Well off to spend some time with my family.Have a great weekend. 1 comment: Diane - I love this post...especially the part about mom jobs. I totally agree with you. Sometimes I feel like I haven't gotten anything done, when I look around and see a mess everywhere. But in reality, a lot has gotten done, you just can't see it sometimes! Once you get your fridge and freezer done, post a pic! I'll share another simple idea for fridges tomorrow! :) About Me I am a mother to an awesome thirteen year old girl and married to a wonderful husband. I decided to blog to help me get organized and share my life experiences too as we go along so we can motivate and support one another !! Slow and steady wins the race they say. Join me on my journey !!!!!!!!!Mac & Shews Serves 8 Time: 1 hour \|\| Active time: 30 minutes I don’t think vegans ever get sick of Mac & Cheese, or, “Cheeze” or whatever. One of the first recipes I ever tried was from one of my all time favorites, the New Farm Cookbook. It was great for me back then because I always had a ton of people over, and you could make it for a crowd at the drop of a hat. So if you were all sitting around watching Evil Dead 2 on repeat, it was only a matter of time before a magical pot of Mac & Cheese would appear and swallow your soul. That recipe is still the prototype for many a vegan Mac & Cheese recipe: lots of nooch, garlic, onions and, wait, what’s that? Half a cup of margarine?! This was the 80s and so it wasn’t even non-hydrogenated margarine. It was the real deal – a bright yellow log of pure processed fat. Today we have less ungodly ingredients to work with, but still, I can’t shake the feeling that when I eat those types of Mac & Cheese, I’m eating melted margarine. So I’ve been toying with different ingredients for the past few years and I’ll probably continue to mess around with it. It’s all about developing flavor and creaminess with ingredients that are still really accessible and really delicious, but also way less processed, and, well really real. To keep things from being one note, I wanted to build flavor with a few simple

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happen. As another Berry, the late Chuck Berry, once sang, “C’est la vie, say the old folks, it goes to show you never can tell.” PG-13? The sometimes earthy nature of coach-to-player communication led to a playful question for former UK players arriving for the preview screening of ESPN’s 30 for 30 film on John Calipari: What rating should be given the film if it accurately portrays how the UK coach communicates? “An honest portrayal would give it a PG-13,” Mark Krebs said with a smile. Kentucky coach John Calipari spoke after the preview screening of his new ESPN documentary, "One and Not Done." The film will air on April 13 at 9 p.m. on ESPN. Caitlyn [email protected] One and not done One viewing of the ESPN 30 for 30 film on UK Coach John Calipari wasn’t enough for UK fan Barry Britton. A Lexington native and UK graduate in the class of 1968, Britton wrote an email asking if and how the film could be purchased. Britten said he wanted copies for two friends who forgot to tape the show. He also wants to add it to his library of UK tapes and books. ESPN said that DVDs will be available at Amazon.com beginning on May 30. A digital version can be bought on iTunes. Heshimu Evans? Heshimu Evans, who played for Kentucky in 1996-97, 1997-98 and 1998-99, attended the ESPN 30 for 30 preview. Although Rick Pitino and Tubby Smith were his UK coaches, Evans said he had a connection to John Calipari. Son also rises Shareef O’Neal, a four-star prospect and the son of Shaquille O’Neal, committed to Arizona last week. Listed as 6-9 and 204 pounds, the younger O’Neal isn’t nearly as physically imposing as his father. Shareef O’Neal was not the only son of a former NBA player on his California-based AAU team. One of his teammates was Bol Bol, the son of Manute Bol. The younger Bol is ranked No. 16 by 247 Sports and has a scholarship offer from Arizona. From the just-wondering file: Has Bol Bol spent any time in Walla Walla? Ex-Cat’s camp Dale Brown (the ex-UK player, not the former LSU coach) plans to stage a basketball camp in Lexington on June 9-10. The camp is for boys and girls ages 6 through 17. Brown, a regular on the UK team that lost the Christian Laettner game and a starter on the 1993 Final Four team, will hold the camp at Calvary Baptist Church. Entry fee is $70. Registration is at Calvary Baptist Church or by calling 404-998-2412 or at [email protected]. Belated birthday wishes To Isaiah Briscoe. He turned 21 on April 13. … To Derrick Jasper. He turned 29 on April 13. … To Mark Soderberg. He turned 67 on April 14. … To Dwane Casey. He turned 60 on April 17. … To Michael Bradley. He turned 38 on April 18. … To Derrick Millar. He turned 49 on April 18. … To Nate Knight. He turned 39 on April 18. … To former UK baseball player Doug Flynn. He turned 66 on April 18. … To Scott Padgett. He turned 41 on April 19. … To Ashley Judd. She turned 49 on April 19. Happy birthday To Ryan Harrow. He turned 26 on Saturday. … To Fred Cowan. He turns 59 on Sunday (today). … To Father Ed Bradley. He turns 74 on Monday. … To Dillon Pulliam. He turns 22 on Tuesday. … To former UK assistant David Hobbs. He turns 68 on Tuesday. … To Bob Tallent. He turns 71 on Wednesday.Customers don’t just buy a product — they switch from something else. And customers don’t just leave a product — they switch to something else. The first workshop sold out in just 5 days, so if you‘d like to attend, register now. It’s in these switching moments that the deepest customer insights can be found. On the 2nd of November, a select group of 24 people will attend a unique, hands-on, full-day workshop to learn about “The Switch”. Most businesses don’t know the real reasons why people switch to — or from — their products. We’ll teach you how to find out. The workshop will be at the 37signals office in Chicago. The cost to attend is $1000. The workshop will be led by 37signals and The Rewired Group. You’ll participate in live customer interviews. You’ll learn new techniques for unearthing the deep insights that most companies never bother to dig up. You’ll understand why people switch from one product to another and how you can increase the odds that the switch goes your way. And you’ll be able to put everything you learned to immediate use. There’s only one simple requirement: You’ll be asked to bring something with you. It won’t be a big deal. Details will be provided one week before the workshop. Spots are limited. Only 24 people will be able to attend and participate. Want to be one of the 24? Register now. We will see you on November 2. George M. This is a very very interesting idea. So many SASS catagories have been multiple competing webapps (accounting or project managment for instance)—switching for MVP feels like a worthwhile strategy. Would like hear more on your thoughts guys! JF on 15 Oct 12 George: Because this isn’t what The Starter League currently teaches. The Starter League teaches Rails, HTML/CSS, and User Experience Design. Further, The Starter League classes are taught on a quarterly system, while this particular workshop is one day. Entirely different topics and teaching methods. George M. on 15 Oct 12 @JF “Further, The Starter League classes are taught on a quarterly system, while this particular workshop is one day.” That statement just plain sounds like your unwillingness to be flexible, because it doesn’t fix the “typical” schedule already in place. That’s really sad to hear, given how much you preach about being flexible and providing a great customer acquisition experience (e.g. Nuts.com great experience, and many-many more..) This doesn’t provide any of that. Maybe that should be lesson #1 of this class. Just a thought. Alex on 15 Oct 12 Would these be relevant for offline/local business (e.g. real estate) or is this only relevant for online? JF on 15 Oct 12 Alex: Highly relevant for offline/local. One of the teachers used to sell houses, in fact. That’s where he learned many of these lessons. Phil C. on 15 Oct 12 I actually went to the last seminar, and would gladly bring my entire marketing and product teams to do it again if I could. What you’ll learn: a simple way of interviewing your customers and clients that will yield insight into what really matters to them. (Importantly, you’ll learn what actually matters to them, not what they say matters, which are two different things entirely. This style of interviewing clients focuses on their actual behaviors and decisions, not on their after-the-fact rationalizations for those decisions or on what they would do in hypothetical situations, as focus groups - and even feature requests - often do.) With that insight, you can then engineer specific solutions to the real, felt problems your customers are looking to solve—and willing to spend their hard earned money to address. Rewired is doing this with some of the largest brands in the world already. Tech companies have some ground to make up in this department. But to Alex: it would be equally valuable for offline businesses. In fact, one of the best case studies we learned about was a hilariously counter-intuitive story of a real estate developer using this technique to increase its sales 20% while the rest of the market plummeted 60%. And making its clients happier in the process. I’d be shocked if they didn’t share that exact case study again, because it’s a classic. In short, this is like usability testing for marketers. Or marketing for engineers, as one person put it. If you like testing, you’ll love this. If you like winging it with your marketing or taking a more intuitive or purely creative approach, you won’t. Roger W. on 16 Oct 12 Jason . . . would this be good for someone offering a service like software training? JF on 16 Oct 12 Roger: Definitely. This is for anyone who wants to understand their customers’ motivations at a much deeper level. If you sell anything, these interview techniques will be very useful. DB on 16 Oct 12 They irony in how many people are confused in what this workshop is for and why they should pay for it … given the topic of the class

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is what we find: Top Spending Districts: average $17,221 per student with scores of 10% readiness in reading and 3% in math. Lowest Spending Districts: average $9,926 per student with scores of 27% in readiness in reading and 22% in math. Clearly there are lots of other factors related to performance other than how much is spent, but the pattern of false choices is clear. Instead of doing real work to figure this out, it’s a lot easier to revert to false choices. Option A – increase education spending or Option B spend less on education. The outcome, we get spending that is unrelated to outcomes. State Government Spending, False Choice #3: There is probably no policy issue that is a better example of false choices than overall government spending. Option A: traditional liberals/Democrats say we need more government spending because we have so many problems in the state that need fixing. Option B: traditional conservatives/Republicans say we need less government spending so people can keep more of their tax money and spend it on what they want, not what the government wants. The outcome is across the board spending cuts or increases. The real issue should be what is effective, what provides the most return on investment or what issues are most pressing. Instead, either side wants to raise or cut spending and so they take the simplistic way out – they split the difference by raising or lowering spending. This principle of split the difference applies not only to overall state spending but it filters down to the political horse trading of spending on individual agencies and programs. This same false choices problem extends to a myriad of other issues: more or less regulation, shorter or longer sentences for criminals, corporate or individual taxes … it goes on and on. It does not have to be this way. What’s needed is a basic common-sense approach not distorted by ideology or special interest lobbyists. We need to ask: does it work, is it effective, is it really important, will it save money in the long run, what is the cost if we do nothing? There is no Democratic or Republican way to fill a pot hole. We need to insist that more is not better, less is not better – but better is better. We will only find solutions to our problem when we realize it’s really about change vs. status quo, about openness vs. closed government, about reformers vs. political insiders, about the people’s interest vs. the special interest, about new innovative leaders vs. corrupt career politicians. We are a great state and we can do great things – with big change and real reform. Phil Noble has a technology firm in Charleston, is founder of World Class Scholars and writes a weekly column for the S.C. Press Association. Reach him at This email address is being protected from spambots. You need JavaScript enabled to view it. and get his columns at www.PhilNoble.com. Produced by Frank van Drogen, Carol Brown, Gwen Adams, Elizabeth Oscanyan, and the Online Distributed Proofreading Team at http://www.pgdp.net. Transcriber's Note: A monospaced font will display the tables in this book better than a variable-spaced font. PRINCIPLES OF POLITICAL ECONOMY BY WILLIAM ROSCHER, PROFESSOR OF POLITICAL ECONOMY AT THE UNIVERSITY OF LEIPZIG, CORRESPONDING MEMBER OF THE INSTITUTE OF FRANCE, PRIVY COUNSELLOR TO HIS MAJESTY, THE KING OF SAXONY. FROM THE THIRTEENTH (1877) GERMAN EDITION. WITH ADDITIONAL CHAPTERS, FURNISHED BY THE AUTHOR, FOR THIS FIRST ENGLISH AND AMERICAN EDITION, ON PAPER MONEY, INTERNATIONAL TRADE, AND THE PROTECTIVE SYSTEM; AND A PRELIMINARY ESSAY ON THE HISTORICAL METHOD IN POLITICAL ECONOMY (From the French) BY L. WOLOWSKI, THE WHOLE TRANSLATED BY JOHN J. LALOR, A. M. VOL. II. [Illustration: Printer's Logo] NEW YORK: HENRY HOLT & CO. 1878. Entered according to Act of Congress, in the year eighteen hundred and seventy-eight, BY CALLAGHAN & CO., In the office of the Librarian of Congress, at Washington, D. C. DAVID ATWOOD, STEREOTYPER AND PRINTER, MADISON, WIS. TO WILLIAM H. GAYLORD, ESQ., _COUNSELOR AT LAW_, OF CLEVELAND, OHIO, TO WHOSE BROTHERLY CARE IT IS LARGELY DUE THAT I LIVED TO TRANSLATE THEM, THESE VOLUMES ARE AFFECTIONATELY INSCRIBED. BOOK III. DISTRIBUTION OF GOODS. CHAPTER 1. INCOME IN GENERAL. SECTION CXLIV. RECEIPTS.--INCOME.--PRODUCE. The idea covered by the word receipts (_Einnahme_) embraces all the new additions successively made to one's resources within a given period of time.[144-1] Income, on the other hand, embraces only such receipts as are the results of economic activity. (See Secs. 2, 11.) Produce (_Ertrag_, _produit_) is income, but not from the point of view of the person or _subject_ engaged in a business of any kind, but from that of the business itself, or of the _object_ with which the business is concerned, and on which it, so to speak, acts. Income is made up of products, the results of labor and of the employment and use of resources. These products, the producer may either consume himself or exchange against other products, to satisfy a more urgent want.[144-2] Hence, spite of the frequency with which we hear such expressions as these: "the laborer eats the bread of his employer;" "the capitalist lives by the sweat of the brow of labor;" or, again, a manufacturer or business man "lives from the income of his customers,"[144-3] they are entirely unwarranted. No man who manages his own affairs well, or those of a household, lives on the capital or income of another man; but every one lives on his own income, by the things he has himself produced; although with every further development of the division of labor, it becomes rarer that any one puts the finishing stroke to his own products, and can satisfy himself by their immediate consumption alone. Hence we should call nothing diverted or derived income except that which has been gratuitously obtained from another.[144-4] [Footnote 144-1: Including of course, gifts, inheritances, lottery prizes, etc.] [Footnote 144-2: Thus the original income of the peasant consists in his corn, of the miller in his flour, of the baker in his bread, of the shoemaker in his shoes. The money which circulates among all these and the purchaser, is only the means of exchanging that part of their products which they cannot themselves use, for other goods. Money, on the other hand, was the original income of the producers of the gold or silver it contains. Compare _Mirabeau_, Philosophie rurale, 1763, ch. 3. _Adam Smith_, II, ch. 2. But especially, see _J. B. Say_, Traite II, ch. 1, 5; and _Sismondi_, N. P., I, 90, 376, in which it is correctly said, that the quality which constitutes anything capital or income does not inhere in the thing itself, but depends on the person. Compare, however, I, 148; _Hermann_, Staatsw. Untersuch. 297 ff., 33 seq.] [Footnote 144-3: A fundamental thought in _St. Chamans_, Du Systeme d'Impot, 1820. Nouvel Essai sur la Richesse des Nations, 1824.] [Footnote 144-4: Thus, for instance, the support given by the head of a family to the members thereof; also gifts, alms, thefts. Even _A. L. Schloezer_, St. A., II, 487, will allow that no one "eats the bread of another," but the person who has received it from the latter by way of favor and for nothing. In the case of a rented house, there is only an exchange of objects of income. The person to whom it is rented gives up a portion of his, and the

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inetochore-chromatin' or '[K]{.ul}-chromatin' (Fig. [4e](#Fig4){ref-type="fig"}). The K-chromatin localisation finding is consistent with our notion that centromeric chromatin is probably targeted by the UFB-binding complex after PLK1 inhibition. If the increased formation of RPA foci at K-chromatin reflects aberrant DNA unwinding, this may weaken centromere rigidity to counteract spindle pulling forces. Notably, we observed detachments of KT complex in a small population of centromeres (\<4%) in metaphase(-like) cells prior to collapse. Intriguingly, some of the KTs remained connected by a short thread, as labelled by PICH or RPA staining (Fig. [5a, b](#Fig5){ref-type="fig"}; arrows). Centromere staining was sometimes evident along the short thread (Fig. [5a](#Fig5){ref-type="fig"}; arrows), implying a protrusion of centromeric DNA. We postulated that this might be the early sign of centromere disintegration. Further analysis of the centromere-KT integrity revealed that there was a large percentage of centromeres losing one of the two sister KTs after metaphase collapse (Fig. [5b--d](#Fig5){ref-type="fig"}). The side of the centromere where a KT was missing was concomitant with the formation of DNA thread linkages (Fig. [5c](#Fig5){ref-type="fig"}; connecting arrows). Therefore, there are apparent alterations on the centromere-KT configuration prior to and during centromere disintegration.Fig. 5Loss of kinetochore attachment at centromeres after dislocation. **a** Representative images showing the kinetochore complex detaches from the core centromere, whilst remaining connected by PICH- or RPA-coated DNA threads (arrows) in BI2536-treated metaphase-like RPE1 cells. Inner and outer kinetochores were labelled by CENPA and NUF2, respectively. **b** Examples showing the majority of centromeres retain two kinetochores in pre-collapsed mitotic populations (prometaphase and metaphase-like cells) after BI2536 treatment. **c** Representative image showing the metaphase-collapse cells losing kinetochore complex at one side of the centromere. Note: the side without the kinetochore is concomitant with the formation of PICH-associated DNA linkages (arrows). Enlarged images (1 and 2) highlight the loss of CENPA signal at regions of where PICH-decorated DNA linkages form (arrows). **d** Quantification of the numbers of CENPA- and NUF2-labelled kinetochores at centromeres in prometaphase, metaphase-like and collapse stages after BI2536 treatment (*n* = 3 independent experiments analysing a total of 3020 CENPA-labelled centromeres and 3625 NUF2-labelled centromeres; mean ± S.D. is shown). Note: all RPE1 cells analysed were pre-synchronised at G1/S by single thymidine block. Drugs were added at 6 h post-release. After 2 h treatment, cells were subject to immunofluorescence staining. Scale bars = 5 μm BLM helicase activity mediates centromere disintegration {#Sec10} -------------------------------------------------------- Next, we examined whether centromere disintegration is mediated by BLM and PICH. We knocked down BLM by RNAi before BI2536 treatment (Fig. [6a](#Fig6){ref-type="fig"}). Silencing BLM for longer than 48 h in RPE1 cells reduced the efficiency of thymidine release, therefore we treated cells with siBLM oligos for only 24 h prior to G1/S release (Supplementary Fig. [12a](#MOESM1){ref-type="media"}). Despite partial depletion (Supplementary Fig. [12b--d](#MOESM1){ref-type="media"}), we found that first, BLM knockdown significantly reduced the formation of RPA foci at K-chromatin induced by BI2536 (Fig. [6b](#Fig6){ref-type="fig"}); second, it also diminished both centromere DNA thread formation and centromere dislocation (Supplementary Fig. [12e, f](#MOESM1){ref-type="media"}). BLM depletion did not impair PICH centromeric localisation (Supplementary Fig. [12g](#MOESM1){ref-type="media"}), suggesting that, without BLM, PICH alone is not sufficient to drive centromere disintegration. To confirm the specificity of BLM knockdown, we performed our analyses on HAP1 cells in which the endogenous BLM was knocked out by CRISPR genome editing^[@CR38]^ (Supplementary Fig. [1](#MOESM1){ref-type="media"}3[a, b](#MOESM1){ref-type="media"}). Consistently, BLM knockout abolished centromere DNA thread formation and centromere dislocations (Fig. [6c](#Fig6){ref-type="fig"}, d). Though, occasionally, chromatid breaks were observed in ΔBLM HAP1 cells, the breakpoint was not at the centromere (Fig. [6d](#Fig6){ref-type="fig"}, arrow). Therefore, in addition to the bipolar spindle pulling forces, BLM is a key driver of centromere disintegration after the loss of PLK1 activity.Fig. 6BLM helicase activity triggers centromere disintegration. **a** Western blot showing BLM depletion after RNAi treatment in RPE1 cells. Ku80 is used as a loading control. **b** BLM depletion reduced centromeric RPA foci formation induced by BI2536 in pre-collapsed metaphase(-like) cells. Representative images showing the loss of RPA, but not PICH foci, at centromeres in siBLM cells. Right: quantification of centromeric RPA foci in metaphase(-like) cells (*n* = 3 independent experiments analysing 60 cells per condition; mean ± S.D. is shown). **c** Representative images and quantification of DNA thread formation in wild-type (HAP1) cells, BLM knockout cells (ΔBLM), and ΔBLM HAP1 cells complemented with a wild-type GFP-BLM (WT) and a BLM-helicase mutant (Q672R) protein under BI2536 treatment (*n* = 3 independent experiments analysing a total of 291, 218, 204 and 184 cells in HAP1, ΔBLM, WT and Q672R cell lines; mean ± S.D. is shown). **d** Representative chromosome images of **'**centromere dislocations' (yellow asterisks) in the indicated HAP1 cells shown in (**c**). Note: occasional arm breaks (arrow) were observed in ΔBLM cells. Quantification of centromere dislocation is shown below (*n* = 3 independent experiments analysing a total of 60, 60, 51 and 51 spreads in HAP1, ΔBLM, WT and Q672R cell lines; means of each experiment are shown). **e** Centromeric RPA foci formation in ΔBLM HAP1 cells expressing wild-type GFP-BLM (WT) and a BLM helicase-dead mutant (GFP-Q672R) following BI2536 treatment. Representative images showing the lack of RPA foci at centromeres in the GFP-Q672R cells. Right: bar graphs showing the average fluorescence intensities of centromere GFP and RPA foci, respectively, in GFP-BLM and GFP-Q672R cells (mean + S.E.M. is shown). A scatter plot of RPA foci intensity by GFP foci intensity at centromeres (total numbers of centromere foci analysed: GFP-BLM, *n* = 582; and GFP-Q672, *n* = 481). All RPE1 and HAP1 cells, including their derivatives, were pre-synchronised at G1/S by single thymidine block. Drugs were added at 6 h post-release. After 2 h treatment, cells were subject to immunofluorescence staining. RNAi treatment of RPE1 cells was performed for 23 h before G1/S release. Scale bars = 5 μm Centromere disintegration might be initiated through unlawful DNA unwinding by BLM. Thus, we determined if BLM's helicase activity is required. We generated polyclonal cell lines from the ΔBLM HAP1 cells, which stably express either a GFP-tagged WT or a helicase-dead (Q672R) BLM protein. The expression of the GFP-Q672R protein was similar to the endogenous BLM level in HAP1 cells; whereas, the GFP-WT was over-expressed (Supplementary Fig. [13b](#MOESM1){ref-type="media"}). In agreement with our notion, the helicase-dead (Q672R) BLM failed to induce centromere DNA threads and dislocations caused by BI2536 treatments (Fig. [6c, d](#Fig6){ref-type="fig"}). However, as the expression level of the GFP-Q672R mutant was lower than the WT control; to perform a better comparison, we re-sorted the WT GFP-BLM cells to obtain a cell population with a lower

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IsNonExpandable="False"> <toolkit:ExpanderView.HeaderTemplate> <DataTemplate> <TextBlock Text="{Binding LocationName}" FontFamily="{StaticResource PhoneFontFamilySemiBold}" LineHeight="{StaticResource LongListSelectorGroupHeaderFontSize}" /> </DataTemplate> </toolkit:ExpanderView.HeaderTemplate> <toolkit:ExpanderView.ExpanderTemplate> <DataTemplate> <TextBlock Text="test" /> </DataTemplate> </toolkit:ExpanderView.ExpanderTemplate> <toolkit:ExpanderView.ItemTemplate> <DataTemplate> <TextBlock Text="{Binding Information}" /> </DataTemplate> </toolkit:ExpanderView.ItemTemplate> </toolkit:ExpanderView> </DataTemplate> </ListBox.ItemTemplate> </ListBox> The ContactViewModel-Class: public class ContactDeViewModel : INotifyPropertyChanged { private string _locationName; public string LocationName { get { return _locationName; } set { if (value != _locationName) { _locationName = value; NotifyPropertyChanged("LocationName"); } } } private List<string> _information; public List<string> Information { get { return _information; } set { if (value != _information) { _information = value; NotifyPropertyChanged("Information"); } } } } And this is where I fill the ContactViewModel: this.ContactDe.Add(new ContactDeViewModel() { LocationName = "Stuttgart", Information = new List<string> { "some text" } } ); this.ContactDe.Add(new ContactDeViewModel() { LocationName = "Böblingen", Information = new List<string> { "more text" } } ); I made a SampleViewModel-File where I have: <vm:MainViewModel.ContactDe> <vm:ContactDeViewModel LocationName="Location 1" /> <vm:ContactDeViewModel LocationName="Location 2" /> </vm:MainViewModel.ContactDe> In the preview-window it shows me 2 ExpanderViews with Location 1 and 2. But the same code doesn't work with the emulator or a real device. I don't really understand which Binding-Acces does what. It would already help me a lot if I could see a full example. I googled many tutorials but most only show 1 side, like a xaml without seing how the data is stored. edit: Now I edited the viewModel, so it's not a List<string> but a List<Info> with Info only containing string Text. So now I can say ItemsSource="{Binding Text}" which should be only 1 string at a time, right? A: As stated in comment to @dellywheel's answer, that you set DataContext this way : d:DataContext="{d:DesignData SampleData/MainViewModelSampleData.xaml}" that set DataContext for use in design-time only, hence it doesn't work in run-time. To set DataContext with similar approach for use in run-time, you can try this way : <ListBox ItemsSource="{Binding ContactDe}"> <ListBox.DataContext> <vm:MainViewModel/> </ListBox.DataContext> ........ ........ </ListBox> or this way to set DataContext in page level : <phone:PhoneApplicationPage> <phone:PhoneApplicationPage.DataContext> <vm:MainViewModel/> </phone:PhoneApplicationPage.DataContext> ........ ........ </phone:PhoneApplicationPage> Another suggestion, prefer ObservableCollection rather than List for use along with data binding. ObservableCollection automatically notify view to refresh whenever item added to or removed from collection. Prevalence and risk factors of osteoporosis in patients with ankylosing spondylitis: a 5-year follow-up study of 504 cases. The objective of this study was to assess the prevalence and risk factors of osteoporosis (OP) in patients with ankylosing spondylitis (AS). Demographic and clinical data of 504 AS patients were collected. Bone mineral density (BMD) measurements of the lumbar spine, proximal femur and forearm were performed by dual-energy x-ray absorptiometry at baseline and follow-up. 106 cases of sex- and age-matched healthy volunteers were enrolled as normal controls. In contrast to normal controls, AS patients displayed a higher prevalence of both OP (9.7% vs. 0%) and osteopenia (57.5% vs. 34.9%). The prevalence of OP was significantly higher and the BMD were significantly lower in patients with elevated erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) than patients with normal ESR and CRP. Juvenile onset, morning stiffness lasting over 0.5 hours and elevated ESR levels were risk factors for bone loss at the lumbar spine; Male gender, older age, hip involvement and lack of regular treatment were risk factors for bone loss at the femur. 173 cases were followed up for 1 to 5 years, BMD changes per year at the lumbar spine, femur and forearm were 4.8%, 2.7%, and 2.6% respectively. There was no significant difference in annual BMD change between patients treated with or without low dose glucocorticoids (GCs). Hip involvement and persistent elevated ESR levels, but not GCs treatment, were associated with decreased BMD at both the lumbar spine and the femur during follow-up in longitudinal regression analysis. High disease activity and hip involvement are risk factors of bone loss in patients with AS. Low-dose GCs treatment in AS does not increase the risk of OP.chr17 1 100 0 chr19 -50 1000 0 chr19 3372152 4121576 1 chr19 4214363 4477570 4 chr19 4709030 4709411 2 chr19 4711183 5069515 3 chr19 5081241 5449223 2 chr19 5535477 5536121 1 chr19 5559281 5561813 4 chr19 5592723 5742913 2 chr19 5861815 5862460 1 chr19 6021539 6022179 2 chr19 6248108 6249473 3 chr19 6427431 6429057 2 chr19 6496595 6497258 1 chr19 6497316 6499591 3 chr19 6530969 6532621 4 chr19 6904460 6905659 2 chr19 6913637 6915725 1 chr19 7000038 7009252 3 chr19 7238983 7241901 4 chr19 7496474 7497832 1 chr19 9063034 10532111 2 chr19 10955709 10956457 1 chr19 11467143 11467813 3 chr19 11874452 11875165 2 chr19 12575094 12576646 4 chr19 12670174 12671551 2 chr19 15868427 15869091 3 chr19 16509957 16511637 1 chr19 16521332 16522096 2 chr19 16841217 16842101 1 chr19 16944579 17912386 4 chr19 19184357 20628964 3 chr19 21546489 21547340 2 chr19 23347635 23464586 1 chr19 23832852 23834404 3 chr19 23966885 23968713 4 chr19 24104526 24105945 2 chr19 24629837 24675579 1 chr19 24935646 24936745 2 chr19 24971366 24973039 3 chr19 24973379 24975947 4 chr19 25073511 25074595 2 chr19 25222902 25223595 1 chr19 25579641 25581567 3 chr19 25678929 25749281 4 chr19 25780994 25781812 2 chr19 26678861 26683116 4 chr19 27291040 27614541 3 chr19 28217754 28218306 1 chr19 28352087 28352654

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); return PEAR::raiseError("Could not write $file."); } } else { fclose($cachefile_fp); $link = function_exists('readlink') ? readlink($file) : $file; return PEAR::raiseError('SECURITY ERROR: Will not write to ' . $file . ' as it is symlinked to ' . $link . ' - Possible symlink attack'); } } fclose($cachefile_fp); return true; } /** * Efficiently Download a file through HTTP. Returns downloaded file as a string in-memory * This is best used for small files * * If an HTTP proxy has been configured (http_proxy PEAR_Config * setting), the proxy will be used. * * @param string $url the URL to download * @param string $save_dir directory to save file in * @param false|string|array $lastmodified header values to check against for caching * use false to return the header values from this download * @param false|array $accept Accept headers to send * @return string|array Returns the contents of the downloaded file or a PEAR * error on failure. If the error is caused by * socket-related errors, the error object will * have the fsockopen error code available through * getCode(). If caching is requested, then return the header * values. * * @access public */ function downloadHttp($url, $lastmodified = null, $accept = false, $channel = false) { static $redirect = 0; // always reset , so we are clean case of error $wasredirect = $redirect; $redirect = 0; $info = parse_url($url); if (!isset($info['scheme']) || !in_array($info['scheme'], array('http', 'https'))) { return PEAR::raiseError('Cannot download non-http URL "' . $url . '"'); } if (!isset($info['host'])) { return PEAR::raiseError('Cannot download from non-URL "' . $url . '"'); } $host = isset($info['host']) ? $info['host'] : null; $port = isset($info['port']) ? $info['port'] : null; $path = isset($info['path']) ? $info['path'] : null; $schema = (isset($info['scheme']) && $info['scheme'] == 'https') ? 'https' : 'http'; $proxy_host = $proxy_port = $proxy_user = $proxy_pass = ''; if ($this->config->get('http_proxy')&& $proxy = parse_url($this->config->get('http_proxy')) ) { $proxy_host = isset($proxy['host']) ? $proxy['host'] : null; if ($schema === 'https') { $proxy_host = 'ssl://' . $proxy_host; } $proxy_port = isset($proxy['port']) ? $proxy['port'] : 8080; $proxy_user = isset($proxy['user']) ? urldecode($proxy['user']) : null; $proxy_pass = isset($proxy['pass']) ? urldecode($proxy['pass']) : null; $proxy_schema = (isset($proxy['scheme']) && $proxy['scheme'] == 'https') ? 'https' : 'http'; } if (empty($port)) { $port = (isset($info['scheme']) && $info['scheme'] == 'https') ? 443 : 80; } if (isset($proxy['host'])) { $request = "GET $url HTTP/1.1\r\n"; } else { $request = "GET $path HTTP/1.1\r\n"; } $request .= "Host: $host\r\n"; $ifmodifiedsince = ''; if (is_array($lastmodified)) { if (isset($lastmodified['Last-Modified'])) { $ifmodifiedsince = 'If-Modified-Since: ' . $lastmodified['Last-Modified'] . "\r\n"; } if (isset($lastmodified['ETag'])) { $ifmodifiedsince .= "If-None-Match: $lastmodified[ETag]\r\n"; } } else { $ifmodifiedsince = ($lastmodified ? "If-Modified-Since: $lastmodified\r\n" : ''); } $request .= $ifmodifiedsince . "User-Agent: PEAR/1.9.1/PHP/" . PHP_VERSION . "\r\n"; $username = $this->config->get('username', null, $channel); $password = $this->config->get('password', null, $channel); if ($username && $password) { $tmp = base64_encode("$username:$password"); $request .= "Authorization: Basic $tmp\r\n"; } if ($proxy_host != '' && $proxy_user != '') { $request .= 'Proxy-Authorization: Basic ' . base64_encode($proxy_user . ':' . $proxy_pass) . "\r\n"; } if ($accept) { $request .= 'Accept: ' . implode(', ', $accept) . "\r\n"; } $request .= "Accept-Encoding:\r\n"; $request .= "Connection: close\r\n"; $request .= "\r\n"; if ($proxy_host != '') { $fp = @fsockopen($proxy_host, $proxy_port, $errno, $errstr, 15); if (!$fp) { return PEAR::raiseError("Connection to `$proxy_host:$proxy_port' failed: $errstr", -9276); } } else { if ($schema === 'https') { $host = 'ssl://' . $host; } $fp = @fsockopen($host, $port, $errno, $errstr); if (!$fp) { return PEAR::raiseError("Connection to `$host:$port' failed: $errstr", $errno); } } fwrite($fp, $request); $headers = array(); $reply = 0; while ($line = trim(fgets($fp, 1024))) { if (preg_match('/^([^:]+):\s+(.*)\s*\\z/', $line, $matches)) { $headers[strtolower($matches[1])] = trim($matches[2]); } elseif (preg_match('|^HTTP/1.[01] ([0-9]{3}) |', $line, $matches)) { $reply = (int)$matches[1]; if ($reply == 304 && ($lastmodified || ($lastmodified === false))) { return false; } if (!in_array($reply, array(200, 301, 302, 303, 305, 307))) { return PEAR::raiseError("File $schema://$host:$port$path not valid (received: $line)"); } } } if ($reply != 200) { if (!isset($headers['location'])) { return PEAR::raiseError("File $schema://$host:$port$path not valid (redirected but no location)"); } if ($wasredirect > 4) { return PEAR::raiseError("File $schema://$host:$port$path not valid (redirection looped more than 5 times)"); } $redirect = $wasredirect + 1; return $this->downloadHttp($headers['location'], $lastmodified, $accept, $channel); } $length = isset($headers['content-length']) ? $headers['content-length'] : -1; $data = ''; while ($chunk = @fread($fp, 8192)) { $data .= $chunk; } fclose($fp); if ($lastmodified === false || $lastmodified) { if (isset($headers['etag'])) { $lastmodified = array('ETag' => $headers['etag']); } if (isset($headers['last-modified'])) { if (is_array($lastmodified)) { $last

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media literates, to stop using Facebook like the 500 million other people out there and find some blocked political blog or something? 5. Who exactly is arguing that satisfaction with the CCP means they “have to stay ignorant about things concerning China”? Why do you even think that? What, caring about Liu and Charter 08 is the key indicator of how much someone knows about things concerning China?” Are you serious? 6. And trotting out the “single source of information” line? Are you serious? How do you know that? You don’t, you assume it. It fits with the brainwashed narrative that is so convenient to slap onto them, doesn’t it? Sure, some, even many, could be guilty of it, but do you really know? There is less know and more eagerness to believe because it reaffirms you of your identity as being different, more “literate”, even “better” than them. Look, there are reasons behind them not sharing your position on and enthusiasm for something you care about. For some, it may very well be the reasons you’re ascribing to them, but how is that conclusion going to help you? How is it going to “help” them? That was a sorry excuse of a reply Kai Pan, really. You replied at lenght without actually saying one thing, and you obviously did not properly read my post either. 1) It’s an English speaking Western University in China, not a Chinese university. They can speak openly about subjects and challenge official viewpoints, neither the students or professors have to self-censor themselves (too much). Point in case: there are lectures about media censorship in China.. 2) being media literate and knowledgeable about world affairs is part of their studies, so there’s no excuse for not knowing such things. 3) Having an opinion (that of the CCP) without secondary sources of information is inexcusable for students of International Business Communications taking courses in Political Economy. That is the whole point, they have an opinion which exactly mirrors the official viewpoint without actually bothering to inform themselves or even read the primary sources (Chapter 08). I clearly stated that having this opinion is no problem nor is it objectionable, what is bad is that they don’t know what they’re talking about. The rest of your reply is just silly so I won’t go into that, judging from the votes some others would probably agree. Simon, I said plenty but I can’t force you to acknowledge them. Oh well. 1) You said “best English speaking University in China”, not “Western University in China”. I don’t think my understanding was unreasonable. Even so, they’re still under the jurisdiction of the Chinese government. You’d be naive to think otherwise. My point still stands. 2) Of course there is. It’s the same excuse as everywhere else, for university students everywhere. All of them have curriculum that advocates becoming media literate and knowledgeable about world affairs but how many are and about all world affairs? You said you attend that university as well, right? I’m certain I can find a topic for which I can apply the same criticism to you. If you haven’t understood yet, my point is that you’re jumping to unreasonable characterizations. 3) How do you know they don’t have secondary sources of information? You’re assuming so based upon your prejudice of their disagreement with you as only possibly coming from one source. You’re operating on the mistaken assumption that “if only they knew this or if only they read this, they would certainly think like me instead of how they think now.” You’re making an arrogant assumption of how compelling the information on “your” side is. Ever consider that they might genuinely disagree with you and for any number of reasons? This is again a symptom of the “they’re brainwashed” narrative you clutch to in order to make sense of their possible disagreement with you. You have to avoid that. I’m not arguing against reading primary sources, Simon. I’m arguing against your eagerness to jump to certain trite conclusions about your peers. I don’t think judging them on what they’re going to say publicly within China is enough to damn them as not being “interested with truly informing themselves.” There are confounding factors that may influence their expression in China that you have to account for. You need to win their confidence and they have to feel safe in opening up to you. Think of it as an experiment and how you control for other factors to get the real data you need to arrive at scientifically rigorous conclusions. You’re jumping to conclusions. Have they read it? Why not? Why won’t they? If they have, what do they think? would they tell you the truth? Why or why not? If they haven’t, again, why not? Do the reasons then suggest that they’re not interested in informing themselves or does it suggest something else? The rest of your reply is just silly so I won’t go into that, judg ing from the votes some oth ers would prob a bly agree. Kai Pan, you’re still not reading what I wrote. I explicitly said it’s ok and perfectly valid to disagree, but you need to know what you’re talking about. I also stated that it’s they themselves who said that they didn’t inform themselves from secondary sources nor read the primary source, I am not “assuming so based on my prejudice”, that’s your own fabrication. The rest of your arguments go along the same lines, you’re attacking a strawman. If you reread what I initially wrote you can clearly see that it’s not the disagreement with their opinions that disheartened the professor (and us Internationals) but their blissful ignorance on the topic, despite being so outspoken in their criticism of the person. Not a single one of them could answer inquisitive questions from the prof to find out why exactly they think so. Blindly following the governments’ official line without a clue is pretty brainwashed I think. And mind, I had many good discussions with Chinese scholars and students, I just tried to highlight that those students who should know the most about these issues often have no clue, if my University is any indication, and that this is exactly the problem as others have highlighted. What “opinion” are you referring to? Note that I’m not accusing you of disagreeing with Chinese people feeling that it is not THAT bad to live in China. I’m disagreeing with your generalizations that Chinese people “aren’t interested in truly informing themselves” simply because they didn’t seem to share your opinions on Liu and Charter 08 when asked in a university class in China. Second, I already addressed the confounding factors with their responses on whether or not they read from non-Chinese sources. As I said, given the sensitivity surrounding the issue, that someone is in JAIL for it, I’m not surprised. You’re taking it at face value. I already warranted that some, even many, of them may indeed be guilty of what you accuse (did I not?), but you’re not that stupid. Consider the circumstances. I never said that you or the professor or other “internationals” were “disheartened” by their disagreement, did I? I disagreed with your rush to jump to the conclusion that they are “brainwashed media illiterates”. Who is the one that needs to reread what who wrote and who is the one attacking a straw man? their blissful ignorance on the topic, despite being so outspoken in their criticism of the person. How were they outspoken? Did they bring up the subject? No, the professor did, to a group of young Chinese nationals inside China with a vested interest in protecting their futures. They’re not like you, Simon. Like Fauna, they don’t have a foreign passport and government to protect them from getting mixed up with Liu and Charter 08. So yet again, I’m not surprised by their responses. And really, what characterizes their public “ignorance” as “blissful” anyway? How do you know they are “blindly” following the government’s line versus toeing the government’s line in self-interest and self-preservation? I brought all of this up already. It is your eagerness to assume brainwashing over self-interest that leads me to accuse you of assuming based upon your own prejudice. You are making faulty assumptions about the students who “should know the most about these issues” based upon how they respond in uncontrolled situations. It’s like asking a husband if he’s ever cheated right in front of his wife. Even if he has, there’s a high probability that he’s not going to admit it. A more nuanced situation is breaching contentious political subjects with people who are distrustful of your motives and intent. You know this, don’t you? Or do you really think people are always going to say what they really think? That they don’t tailor their answers to the circumstances or to how they feel about the other person? I’m asking you to consider these factors before jumping to generalizations about how “interested” they are in “truly informing themselves”. The “they’re brainwashed” narrative is such a cop-out. There is enough evidence of Chinese people, especially educated Chinese people, being capable of thinking critically about politics. No one is denying that there is plenty of evidence that there are plenty of educated Chinese people who aren’t, but why the rush to judge when there are so many confounding factors to consider? More of my less

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SDS‐PAGE gel, the transfer was verified using Ponceau S (Sigma), transferred to nitrocellulose membrane and blocked in Tris‐buffered saline containing 5% BSA (Sigma) and 0.05% Tween‐20(Sigma). The primary antibody against Total HER2 (sc‐33,684 Dilution 1:500), Total EGFR (1005) (sc‐03 Dilution 1:500), Total ERK2(C‐14) (sc‐ 154 Dilution 1:500) and β‐Actin(I‐19)‐R (sc‐1,616‐R Dilution 1:3000) were obtained from Santa Cruz biotechnology. The primary antibodies Phospho‐HER2 (Tyr1248) (AP0152 Dilution 1:500) from Abclonal and Phospho‐p44/42 (T202/Y204) MAPK (\#4370) Dilution 1:1000), Phospho‐*EGFR* (Y1068) (\#2234 Dilution 1:500) were obtained from Cell signaling technology respectively. Thiazolyl blue tetrazolium bromide (MTT, TC191) was obtained from Hi‐Media. Receptor tyrosine kinase proteome array {#ijc31916-sec-0015} --------------------------------------- The relative amount of 49 tyrosine kinases were evaluated using Proteome Profiler Human Phospho‐ RTK array kit (ARY001B -- Proteome Profiler, R&D systems) and the protocols were followed as per manufacturer\'s recommendation. Briefly, cells were harvested, washed with 1X PBS and lysed after which 400 μg of protein was mixed with a buffer and incubated with preblocked nitrocellulose membrane at 4 °C. Subsequently, the membranes were probed using detection antibodies and probed using streptavidin‐HRP, after which signals were developed using the chemi‐reagents provided with the kit. The Pixel density of each spot in the array in duplicate was quantified using Image J macro‐Protein array analyzer plug in. The average pixel density of the duplicate spots for each of the kinases was subtracted from the negative density and was plotted, as detailed earlier.[35](#ijc31916-bib-0035){ref-type="ref"} Invasion assay {#ijc31916-sec-0016} -------------- Invasion ability of the cells was assessed in Transwell system using cell culture inserts for 24 well plates with 8 μm pores (BD Biosciences, NJ). The upper side of the cell culture insert was coated with Matrigel (BD Biosciences, San Jose, CA). GBC cells were seeded at a density of 2 × 10^4^ on the upper side of the coated Matrigel in presence of serum free DMEM. Complete DMEM media with 10% FBS was added to the lower side of the insert and were incubated at 37 °C in 5% CO~2~ incubator for 12‐14 h. Post incubation the non‐migratory cells on the lower side of the cell culture insert were removed using a cotton swab. The transwell chambers were fixed and stained with 0.1% crystal violet. The invasion ability was estimated by counting the cells that have migrated to the lower side of the cell culture insert. Cells in visual field with a magnification of 20X were counted in each Transwell chamber in triplicates. Wound healing assay {#ijc31916-sec-0017} ------------------- Confluent monolayers in 6‐well plate were subjected to scratch with a sterile pipette tip. After this, cells were washed with 1× PBS to remove debris and subsequently incubated with media. Cell migration at the wound surface was measured during a period of 20 h under an inverted microscope. The quantification of cell migration was done using Cell Profiler[36](#ijc31916-bib-0036){ref-type="ref"} wound healing pipeline for three independent wounds in three independent experiments. Immunohistochemistry {#ijc31916-sec-0018} -------------------- Immunohistochemical analysis was done using the standard protocol of Vectastatin Universal kit. Briefly, antigen retrieval was performed by incubating the slides in preheated citrate buffer (pH 6) using a pressure cooker for 10 min. The slides were allowed to cool at room temperature before rinsing with TBST (Tris‐Buffered saline‐ Tween 20 (1%). The endogenous peroxidase activity was blocked by incubating the slides in 3% hydrogen peroxide. The slides were blocked by horse serum for 1 h before incubating with the primary antibody (HER2 DAKO A0485, Phospho‐p44/42 (T202/Y204) MAPK \#4370, Total ERK2(C‐14) sc‐154) for overnight at 4 °C in moist chamber. Post incubation the slides were rinsed with TBST and incubated with universal secondary antibody (Vectastatin). The chromogenic reaction was performed using 3′‐3′‐ diaminobenzidine chromogen solution for 5 min which results in brown signal. The slides were rinsed in deionized water and counterstained with hemotoxylin. Finally, the slides were dehydrated and mounted with a mounting medium and cover slip. Coimmunopreciptation assay {#ijc31916-sec-0019} -------------------------- For immunoprecipitation, cells were harvested in NP‐40 lysis buffer (50 mM Tris pH 7.4, 150 mM NaCl, 0.5% NP‐40, 1 mM EDTA along with protease and phosphatase inhibitors), Protein lysate supernatant were combined with the anti‐EGFR antibody and incubated overnight on a rotator at 4 °C. Protein G‐Sepharose beads (50 μL) were added to the cell lysates the next day and were on a rotator at 4 °C for 4 h. The Protein G‐Sepharose beads were isolated by centrifugation at 2000*g* for 2 min. Further, these beads were washed three times with NP‐40 lysis buffer and heated for 10 min at 100 °C in loading buffer. Samples were run on SDS‐PAGE and then probed by immunoblot for HER2. *In vivo* study {#ijc31916-sec-0020} --------------- Five‐ to six‐week old female NOD‐SCID mice were injected subcutaneously with 3 × 10^6^ cells/mL in 100--200 μL PBS G415 (*N* = 13), NOZ (*N* = 10) and OCUG1(*N* = 10). After injecting the cells, the size of the resulting tumors was determined every third day using calipers. Afatinib inhibitor was administered to the randomized group of mice by oral gavage at 15 mg/kg body weight along with vehicle control (1% Tween 80) for a period of 15 days after the tumor volume has reached between 100 and 150 mm^3^. micro PET‐CT scan was performed at the end of drug treatment. The tumor volume was calculated using the formula -- (Width^2^ \* Length) /2. After 15 days, the mice were euthanized with CO~2~. Tumors were excised and tissues were stored for molecular and histopathological analysis. Statistical analysis {#ijc31916-sec-0021} -------------------- Prism software (GraphPad) was used to analyze proliferation and drug sensitivity of cells to inhibitors, and to determine the statistical significance of differences between the groups by applying an unpaired Student\'s *t* test. *p* Values \<0.05 were considered significant. The Kaplan--Meier estimation of patient survival and correlation analysis were assessed using R packages survival (<http://cran.r-project.org/package=survival>), and IBM SPSS v20. Study approval {#ijc31916-sec-0022} -------------- The study protocols were approved by ACTREC‐TMC Institutional Review Board, Project \#104. The animal study protocols were approved by Institutional Ethics Animal Committee of ACTREC. Availability of Supporting Information {#ijc31916-sec-0023} -------------------------------------- The datasets supporting the results of this article are available from the ArrayExpress database (accession number E‐MTAB‐6619). Results {#ijc31916-sec-0024} ======= Integrated genomics and proteomics approach identify aberrant alterations in members of the *EGFR* family in gallbladder cancer {#ijc31916-sec-0025} ------------------------------------------------------------------------------------------------------------------------------- We performed whole‐exome sequencing on paired tumor and germline DNA samples from 17 patients with gallbladder cancer and 5 gallbladder cancer cell lines (Supporting Information Table [S1](#ijc31916-supitem-0001){ref-type="supplementary-material"} and [S2](#ijc31916-supitem-0001){ref-type="supplementary-material"}). We achieved \>100‐fold mean sequence coverage of targeted exonic regions. The average nonsynonymous mutation rate was found to be 7.7 mutations per megabase (Supporting Information Table [S3](#ijc31916-supitem-0001){ref-type="supplementary-material"}), which is significantly higher than as reported for other populations.[37](#ijc31916-bib-0037){ref-type="ref"} The nucleotide mutation pattern was observed to be enriched for C\>T transition followed by A\>G transition (Supporting Information Fig. [S1](#ijc31916-supitem-0001){ref-type="supplementary-material"}), consistent with previous reports.[37](#ijc31916-bib-0037){ref-type="ref"} A total of 5,060 somatic variants found across 17 tumors consisted of 3,239 missense, 1,449 silent, 131 nonsense, 135 indels and 106 splice site mutations. Somatic mutations in genes previously reported to be altered in gallbladder cancer, including recurrent mutations in *TP53* (35.2%)

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gotten what he needs, so he moves to the next place, the next job, the next attempt to find something worth staying for, always landing at the top of his game, but never feeling like he belongs. A Restored Man: The Men of Halfway House, Book 3 Cole Renzo thinks his greatest challenge is to behave for the remainder of his term at Halfway House. Until he meets his new boss, Ty Calloway, a man who ticks off every box on Cole's list of interests. A sought-after restorer and customizer of exotic and collectible cars, Ty had enough confidence to command what he wanted in life, until one fateful night changed everything. Almost two years later, he's slowly rebuilding his life with great control. He's defied the odds and works tirelessly to be the man he once was - but he still feels broken. The Truth as He Knows It: Perspectives, Book 1 Officer Noel Carlson isn't out to anyone in small-town Stratton, Pennsylvania, so a relationship is out of the question. That doesn't stop him from wanting one, though. When a night-shift call brings him face-to-thonged-butt with a hired stripper whose girl-party gig went terribly wrong, Noel takes pity on the guy and lets him go. But he can't get the encounter out of his mind. Breakaway: Scoring Chances, Book 1 Drafted to play for the Jacksonville Sea Storm, an NHL affiliate, 20-year-old Lane Courtnall's future looks bright, apart from the awkwardness he feels as a gay man playing on a minor league hockey team. He's put his foot in his mouth a few times and alienated his teammates. Then, during a rivalry game, Lane throws off his gloves against Jared Shore, enforcer for the Savannah Renegades. It's a strange way to begin a relationship. Crossing Borders Tristan knows he's got issues. His latest ex-girlfriend knows it too. He can't blame her for dumping him - even though she gets her brother to do it for her. Since he can't stop staring at said brother's package, he figures it's about time to put a label on those issues. He likes guys. He heads to a local bookstore with what he's sure is a foolproof plan to find someone to show him what he's been missing. But who should crash his little adventure? Officer Michael Truax, who gave him a really expensive ticket back in high school. Publisher's Summary Ten years ago David Worral had plans to go to college and the potential for a beautiful future in front of him. One tragic accident later, he fled to California and reinvented himself as Dex, top porn model of Johnnies. Dex's life is a tangled mess now, but the guys he works with only see the man who makes them believe even porn stars can lead normal lives. When Kane, one of Dex's coworkers, gets kicked out of his house, the least Dex can do is give him a place to stay. Kane may be a hyperactive muscle-bound psycho, but he's also a really nice guy. What could be the harm? Except nothing is simple - not sex, not love, and not the goofy kid with the big dick and bigger heart who moves his life into Dex's guest room. When they start negotiating fractured pasts and broken friends, Dex wonders if Kane's honest nature can untangle the sadness that stalled his once - promising future. With Kane by his side, Dex just might be able to reclaim the boy he once was - and if he can do that, he can give Kane the home and the family he deserves. Loved this book. Amy Lane at her best - I think this will be a great series of books. A particularly sexy instalment. Can't wait for the next one. 3 of 3 people found this review helpful Kindle Customer The Woodlands, TX 21/04/14 Overall Performance Story "Read it already, but bought the audio," Would you listen to Dex in Blue again? Why? Yes, read the book then bought the audio. This is a tie between the first and the second in the series. I love Chase in Dark and I love this one. Sean Crisden is one of my favorite narrators and he does not disappoint in this one. Who was your favorite character and why? ?? I love them all, Dex (David), and Kane (Carlos). I love this relationship, and I love Dex in his role in Johnnies. When he slept with Tommy in the first book, I had a problem with loving him, but quickly got over it. Have you listened to any of Sean Crisden’s other performances before? How does this one compare? Many by this narrator. Great as always. He can turn a bad book into a good listen just due to his narration. Who was the most memorable character of Dex in Blue and why? Dex and Kane, I do love Ethan and cannot wait until his comes out. Any additional comments? Worth the money, now I own the book and audio, I will listen again and again. 3 of 3 people found this review helpful Heather Seattle, WA, United States 18/04/14 Overall Performance Story "More of Johnnies boys falling in love." This story is the 2nd story Amy wrote about the boys from Johnnies. Dex's story starts long before you meet him in Chase in Shadow, giving us his back ground, but it quickly becomes concurrent to Chase and Tommy's timeline. While the title states Dex, the story is about both Dex and Kane falling in love and making it work. You will love Kane's innocence and Dex's strength. Families are what we make them - and Amy makes them amazing! 3 of 3 people found this review helpful Belen United States 17/02/16 Overall Performance Story "Wonderfully narrated by Sean Crisden" Any additional comments? This is wonderfully narrated by Sean Crisden! I enjoyed the character voices, the pacing, the intimate scenes, as well as most of the story. Which is great, because I was really looking forward to David/Dex's story, and getting to see him fall in love with Carlos/Kane was a treat. David "Dex" Worral has been working for Johnnies for nine years and has become the right hand man who keeps everything afloat. It's Dex who schedules and handles most of the business. While his professional life is right on track, and it's true he's doing really well, it seems like the only thing missing from Dex's life is someone to love who loves him back. As it happens in romances, a character sometimes has to be with someone not worthy in order to see the guy who is worthy. After breaking up with his douche-nozzle ex, the "right" guy finally comes along and when Carlos "Kane" Ramirez shows up on Dex's doorstep needing a place to stay, it turns into more between the two quickly, and they fall in love. It was a really sweet thing to witness the two bond and be there for each other through thick and thin. I love these two characters! The only negative for me was I felt like much of the last quarter was unnecessarily over-dramatic. It put me off the flow of the story and jarred me. I really didn't see the need and it felt like a sort of "Oh, things are going too well for the characters, I have to throw some angst in here!" and then a whole bunch of things happen that didn't feel organic to the story. Bottom line: I enjoyed the story, the characters, and especially the narration. I would not hesitate to recommend this to anyone looking for a romance with a medium-level of angst, sweetness, hot sexy times, and likable characters. Recommended. 2 of 2 people found this review helpful Marilyn GLASTONBURY, CT, United States 09/07/14 Overall Performance Story "A well-told, heart-warming story from the get-go" The story is about a young gay man who comes to understand who is he and what it will take to get out of life what he wants and deserves. It is not a heavy or deep story, but accurate and meaningful in terms of the feelings and growth involved. You will come to love both the main characters as well as the background ones, who each have their own book in the series. My only criticism is the reader. His voice seems more mature than the characters' ages are supposed to be. At times he adopts a childish lilt/tone to account for that or differentiate between different character's voices. Also, one of the main characters has an LA Mexican way of talking that the narrator can't quite pull off (mainly to the aforementioned childish lilt, which makes the character sound like a whiny child). I did, however, get used to his voice and found that it didn't detract so much as it left me just wishing it were different/better. This is the first book in this series that I listened to. I don't know if it's the first in the series or not, but it

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Toronto, said the opportunity to have real input was too good to pass up. "That's the mandate of Spacing, to help make Toronto better," he said of the ideas he's suggested to transit officials. "Each time I present them they say, `This is a great idea,' and that's the end of it." Blackett tried to persuade the TTC to merchandise the station-stop buttons Spacing created. But officials wouldn't listen to his pitch, he said. Now there are about 120,000 buttons in circulation. The panel's recommendations will be based on a review of employee customer service training; the TTC's complaint process; hiring criteria for frontline workers and a customer charter of rights. The Toronto Star and thestar.com, each property of Toronto Star Newspapers Limited, One Yonge Street, 4th Floor, Toronto, ON, M5E 1E6. You can unsubscribe at any time. Please contact us or see our privacy policy for more information. More from the Toronto Star & Partners LOADING Copyright owned or licensed by Toronto Star Newspapers Limited. All rights reserved. Republication or distribution of this content is expressly prohibited without the prior written consent of Toronto Star Newspapers Limited and/or its licensors. To order copies of Toronto Star articles, please go to: www.TorontoStarReprints.comdeprecated: true # moved to stable name: kubewatch version: 0.2.3 appVersion: v0.0.3 description: DEPRECATED Kubewatch notifies your slack rooms when changes to your cluster occur home: https://github.com/skippbox/kubewatch keywords: - kubernetes - slack sources: - https://github.com/skippbox/kubewatch engine: gotpl Introduction {#S1} ============ Essential tremor (ET) is a neurological condition that causes shaking or rhythmic motion in body parts. ET is characterized by a positional and/or volitional 4- to 12-Hz tremor that can affect all body parts ([@B40]) and affects nearly 1% of the world's population, increasing to 4% of those over age 40 ([@B43]). Although the preferred treatment for ET is pharmacology based, medications for ET may decrease in efficacy over time or not be efficacious ([@B7]). It is estimated that pharmacological treatment can improve tremor in only 50% of patients ([@B38]). Therefore, deep brain stimulation (DBS) becomes an alternative treatment option when medication is not effective or not tolerated in patients with disabling tremor ([@B63]; [@B10]). Ventral intermediate nucleus of the thalamus (VIM) is a well-established DBS target for ET ([@B12]), because the VIM is a cerebellar relay nucleus in the ventrolateral (VL) part of the thalamus and is known to be involved in ET ([@B2]; [@B26]; [@B52]). The VIM shows abnormal neuronal discharges in humans with ET ([@B12]). The cerebral cortex is also a part of the tremor-generating neuronal network ([@B25]; [@B50]). The corticothalamic anatomical connections are well established ([@B50]; [@B49]). Thalamic neurons receive robust input from corticothalamic feedback neurons, thereby allowing the cortex to communicate continuously with the thalamus during sensory processing ([@B5]). Corticothalamic feedback neurons reside in cortical layer 6 and give rise to axons that terminate both in the thalamus and in the layers of the cortex receiving thalamic input ([@B54]; [@B58]). Recently, several studies have suggested that cortical thickness could be used as an ET diagnosis with a high accuracy ([@B9]; [@B6]; [@B53]; [@B3]), which may partly reflect a decrease in the amount of corticothalamic connections. In the study of connectivity for the cerebello-thalamo-cortical network in humans, when tremor is severed, M1 has reduced cerebellar functional connectivity, whereas the thalamus has increased cerebellar functional connectivity ([@B33]). Thus, there is evidence for alterations in cerebello-thalamo-cortical circuit activities directly influencing ET. In the neurophysiological view, rhythmic firing patterns such as oscillations and bursts have been considered as a way to process information in the brain ([@B57]; [@B28]). Therefore, we hypothesized that DBS at the VL thalamus (VLT), which is a homolog of VIM in humans, may act through changing neuronal firing patterns in the primary motor cortex (M1). To test our hypothesis, we investigated changes of M1 neuronal activities while high-frequency VL thalamic DBS (130 Hz) was applied in harmaline-induced tremor rats. Here, we demonstrated that four neuronal discharge patterns exist in M1 and VLT and those were changed by harmaline. Our data also show that high-frequency thalamic DBS changed the proportion of four different firing patterns of M1 activities; and these changes have a residual effect, which was maintained even after the termination of DBS in harmaline-administered rats. Materials and Methods {#S2} ===================== Animals {#S2.SS1} ------- Subjects were adult Sprague--Dawley rats weighing 270--350 g (34 rats for behavior only, 8 rats for M1 recording, 15 rats for VLT recording). Animals were maintained under standard laboratory conditions on a 12/12-h light/dark cycle (lights on at 7:00 a.m.), and they had free access to food and water. All experimental procedures were approved by the Mayo Clinic Institutional Animal Care and Use Committee for experimental animals. Tremor Induction and Measurement {#S2.SS2} -------------------------------- Tremor was induced by intraperitoneal (i.p.) injection of harmaline (harmaline HCL, Sigma-Aldrich, St. Louis, MO, United States). Harmaline was dissolved in saline and administered at a dose volume of 5, 7.5, 10, and 20 mg/kg. Tremor was measured with the force-plate actimeter (FPA, BASi, Lawrence, KS). A force-sensing actimeter was confined to a horizontal sensing area by an enclosure suspended a short distance (2 mm) above the upper surface of the force plate (440 mm^2^ × 440 mm^2^) ([@B19]). Four force transducers existing below the corners of the plate recorded the animals' position on a Cartesian plane and measured the force exerted on the plate at each time point. Data were collected and stored in the duration of 10.24 s as 1 frame with 100 points per second as a sampling frequency. Rats were placed on the force plate, and their movements were measured for 4 h 16 min (1,500 frames). Harmaline was injected following 20 min of movement recording for a baseline. The experiment was performed over five consecutive days. DBS Electrode Implantation Surgery and Application {#S2.SS3} -------------------------------------------------- Rats were anesthetized with 2--3% isofluorane and mounted in a stereotactic device (David Kopf Instruments, Tujunga, CA, United States). Two screws were located on the skull for attaching the electrode. Customized concentric bipolar electrodes were 1.07 mm in the diameter of the outer shell, and the inner and outer cores were made with stainless steel wires, 300 and 700 μm in diameter, respectively. The electrode was stereotactically implanted into the VLT \[anterior--posterior (AP) -- 2.3 mm, medial--lateral (ML) ± 1.8 mm from the bregma, and dorsal -- ventral (DV) -- 5.6 mm from the brain surface, according to the [@B48] rat brain atlas. The electrode was attached to the skull with screws using dental cement. After implantation surgery, the animals were placed in a cage for at least 1 week to recuperate. After full recovery from the electrode implantation surgery, the animals were placed in a force-plate actometer. The electrode was connected to a stimulus generator (AM system, World Precision Instruments, Sarasota, FL, United States). After 20 min of baseline movement recording, high-frequency stimulation (130 Hz, rectangular pulse width 100 μs) was applied for 10 min followed by 10 min off stimulation. After that, low-frequency stimulation (10 Hz, rectangular pulse width 10 μs) was applied for 10 min followed by 10 min off stimulation. Then, harmaline was administered intraperitoneally at a dose of 10 mg/kg; and 30 min later, the stimulation procedure described above was repeated. Tremor Analysis {#S2.SS4} --------------- Tremor data were filtered by the Hanning window and converted to power spectra of frequency by a fast Fourier transform (FFT) on each frame of the experiment using MATLAB (MathWorks, Cambridge, MA, United States). For each frame, the total motion power from 0 to 25 Hz (full motion spectrum) and the motion power from 8 to 12 Hz (the harmaline-induced tremor frequency bandwidth) were calculated. Next, the power spectra from 8 to 12 Hz was divided by the power spectra 0--8 Hz for each frame ([@B41]). Then, the resulting motion power ratio (MPR) for each 10-min epoch was generated by averaging the data from 1 frame. Each 10-min MPR was normalized by the averaged 20-min baseline MPR. Electrophysiological Recordings and Stimulation {#S2.SS5} ----------------------------------------------- Electrophysiological experiments were performed in anesthetized rats with urethane (1.5--1.6 g/kg

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ilogue--I'm a sucker for epilogues anyway but this one was beautiful! BOOK SUMMARY... Nina is 36. She's blonde headed, with hazel eyes and very pretty. She lives in England and is an attorney. She's engaged to a douchbag who doesn't care about her at all. She's very put together, almost to the point of snooty in the beginning. She' was a strong character. She didn't take crap from anyone including Max at times. She had no problem standing up for others or herself. She had a "take on the world" feel to her and I loved her instantly. Max is 37. he's tall with broad shoulders, dark wavy hair, and grey eyes. He is the owner of the house Nina is going to rent while she's on vacation. He's dark and imposing in the beginning, very unapproachable. He's domineering, possessive, and a bit controlling...in and out of the bedroom. He sees something he wants and he goes for it. He was married 10 years before but lost his wife in a car accident and has since played the field thinking he'd never find love again. Nina is taking a break from her life. She's left her fiance, her life, and everything else behind for 2 weeks. Her plans are to get to the house she's rented and sort through her feelings. She's has a fiance named Niles who could care less that she's gone. He doesn't call to make sure she made it safely or anything. It's snowing and she's getting sick. All she can think about is getting to her destination and going to bed. Once at the house, she realizes there is a mix up. The owner is home and the booking was wrong. He's a jerk and sends her own her way. She being the person she is, has no intention of going down with a fight. They fight outside in the snow, he tells her to stay the night, and she's so stubborn she refuses. She ends up in a ditch not far from his house. She's had enough and takes some medicine and falls asleep in the backseat praying someone will find her. The following morning she wakes up in Max's bed in the house she left the following night sick as a dog. Like death flu sick. Over the next several days Max takes care of her. He feeds her, makes sure she's taking medicine, and when she's shivering uncontrollably he gets into his bed with her and holds her until she's calm again. She's out of it but knows some of what's going on. Following her illness she wakes up mortified with one thought...Get far far away. There's just one problem with her plan to leave...Max won't let her. She needs her rest and she's staying, end of story. He's goes so far that he takes her keys and calls the cab company and tells them not to come get her if she calls while he's out. For her nothing has changed but for him, he's spent the last 48 hours taking care of him and now he wants to get to know her. He flirts and lets her know that if she were his... "If you told me you needed a timeout, first, I wouldn't f***in let you have one, second, I wouldn't give you reason to f***in want one, last, you took off anyway, I'd f***in phone." He takes her to dinner which ends up being their first date. He's trying to get to know her but she argues with him about everything. Seriously they even argue about the nationality of beer. We meet Shauna, who is a woman Max used to sleep with. She's a horrible person and I couldn't stand her. Once back at the house she goes to bed and wakes up in his arms. When she tries to pull away, he pulls her back to him. She's still set on leaving but he kisses her. The following morning he takes her to his "spot" which is a bluff on his mountain. He doesn't take a lot of people there but he took her only having known her a few days. Following their day together, she sends Niles a "dear John" letter home through an email, ending her 2 year relationship. They begin spending time together, sleeping curled around each other every night. He is constantly calling her "his woman". It's sweet. (Yes, I'm going all swoony on you) We meet Mindy and Becca. Mindy is Max's best friend's (Brody) little sister. Nina gets the wrong idea but Mindy is like his little sister. Becca is Mindy's best friend who is also close to Max. We find out that Nina's brother was hurt in the army. He lost his legs and in coming home lost everything else he valued. He gave up and committed suicide. Having the wrong idea about Mindy, Nina delivers this information rather bluntly and harshly. When she leaves the room, Max lets Nina know who she is and what she means to him. He then tells her she was harsh and that Mindy had been raped 3 weeks prior and didn't need that from her. Her and Mindy get to know each other and end up having a girls night with a few other females in town. Mindy's boyfriend is a total douchebag and blames Mindy for what happened. When he gets ugly with Mindy, Nina jumps in and ends up getting backhanded across the face. Max walked in a the exact moment this happens and beats the crap out of him. Max is trying his best to spend time with her alone but they are constantly interrupted. Max isn't a fan of being interrupted. Nina is fully aware of what Max wants their alone time to consist of. He has no problem letting her know that he wants to be with her. On the way to dinner he tells her he wants her to move to Colorado, live in his house, and start a life with him. (It's not even been a full week!) She isn't quite getting it yet but he has no intention of letting her go now that he has her. She's officially been claimed. We find out about Max's wife when Nina discovers their picture at Bitsy's house (friend of Max and wife of the man who was married earlier in the book...didn't mention it because I really didn't see the point). She can tell how happy they were and how much he loved her. She gets this idea in her head that if he has already been with the love of his life then she can never be that for him. Without even talking to him she makes the decision to not even try. She's trying to run and he's trying to plan their future. He knows somethings up but can't get through to her. At dinner they run into Shauna again. This confrontation was funny. Her dad shows up in town and she gets in a screaming match with him and slaps him. Max has to pull her back. This girl is feisty when she's mad. Her mom and step dad show up and he and Max go to talk to her father. Max finds out at the meeting that Niles is on his way to town and they have to meet with them the following morning. It doesn't go well. Niles shows his true colors and we find out that her dad offered Max $250,000 to walk away. Mindy tries to commit suicide but they get to her in time and Nina takes over showing how strong she is. She rushes into the water and pulls her out then performs CPR. She promises her she'll help her get the help she needs and eventually does. When she and Max are finally alone, he's angry that she jumped in the water. They fight, make up and then finally have sex. It's hot and he's so dominate with her. Now that they have officially done the deed, she's his and he has no intention of letting her walk away. Anna gets the full story about Max and Anna from a very drunk Harry (another friend of Max) and he's none to nice about it. Tells her she'll never be Anna and that he'll never love her the way he loved Anna. She shuts down and won't talk to him. She's planning on getting through the night and leaving the next morning. Max hears a recorded conversation with Bitsy and realizes that Nina already knows about Anna while he's been trying to figure out how to tell her. He's so angry and says some really mean things. He pretty much tells her they are done and walks away. She being Nina packs up her things and takes off to a cabin in the woods. Damon, Mindy's boyfriend she hit, finds her and beats the crap out of her. I mean seriously this girl goes on vacation and it sucks (minus hot, sexy mountain man who claims you)! "I mean, I go on a vacation to try to figure out my life and here I am, my legs's scraped up, my ribs are bruised, I've been backhanded and punched, I've been to a hospital once and a Police Station three times and I've been into it with practically everyone in town and, if you take out the time I've been sick, I've only been here a week!""I need a timeout to deal with my timeout!" Max began tracking her down the minute he realized she was gone (about the moment he cooled off and realized he needed to talk to her) and when he finds her and sees the damage he's angry. After a trip to the hospital he finally talks to her about Anna and then tells her that part of his life is over and Nina is who he

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flow wake are utilized for the calibration. This work is only one piece in the complete process of calibration and validation of LES models to issue predictions of QoIs with quantified uncertainties, and many open questions remain. We do not attempt to fit the numerical solutions with physical data herein, as the two-dimensional model has been known to show remarkable discrepancy with the experiment results. Applying our framework to the three-dimensional simulation for parameter calibration against real-world data would be the next logical step. [Another important problem is to evaluate and compare the performance of our AHSG with other surrogate methods (including some listed above) in this process. This would be conducted in future research.]{} [Also,]{} characterization and quantification of the structural inadequacy and comparison of different competing LES models are beyond the scope of this study. The rest of the paper is organized as follows. The Bayesian framework and the adaptive hierarchical sparse grid method of constructing the surrogate system are described in §\[sec:surrogate\]. In §\[sec:les\], we give a detailed description of the Smagorinsky model of sub-critical flow around a cylinder. The performance of surrogate modeling approach and results of the Bayesian analysis are presented in §\[sec:result\]. Finally, discussions and conclusions appear in §\[sec:conclusion\]. Adaptive hierarchical sparse grid methods for surrogate modeling in Bayesian inference {#sec:surrogate} ====================================================================================== Bayesian inference ------------------ Consider the Bayesian inference problem for a turbulence model $$\begin{aligned} \label{def} \bm{d} = \bm{f}(\bm{\theta} ) + \bm{\varepsilon},\end{aligned}$$ where $\bm{d} = (d_1,\ldots, d_{N_d})$ is a vector of $N_d$ reference data, $\bm{\theta} = (\theta_1, \ldots,\theta_{N_\theta})$ is a vector of $N_\theta$ model parameters, $\bm{f}(\bm{\theta})$ is the forward model, e.g., Smagorinsky model (see §\[sec:les\]), with $N_{\theta}$ inputs and $N_d$ outputs, and $\bm{\varepsilon}$ is a vector of residuals, including measurement, model parametric and structural errors. [(Nonlinear model $ \bm{d} ={\bm \Xi}(\bm{f},\bm{\theta},\bm{\varepsilon})$ can be considered as well, but leads to more complicated likelihood functions, as $\bm{\varepsilon} = \bm{\Xi}^{-1}(\bm{f},\bm{\theta})(\bm{d})$).]{} The posterior distribution $P(\bm{\theta}|\bm{d})$ of the model parameters $\bm{\theta}$, given the data $\bm{d}$, can be estimated using the Bayes’ theorem [@BT92] via $$\label{s2:e2} P(\bm{\theta}|\bm{d}) = \frac {L(\bm{\theta}|\bm{d})P(\bm{\theta})}{\int L(\bm{\theta}|\bm{d})P(\bm{\theta})d\bm{\theta}},$$ where $P(\bm{\theta})$ is the prior distribution and $L(\bm{\theta}|\bm{d})$ is the likelihood function that measure “goodness-of-fit” between model simulations and observations. In parametric uncertainty quantification, the denominator of the Bayes’ formula in equation is a normalization constant that does not affect the shape of the PPDF. As such, in the hereafter discussion concerning building surrogate systems, the notation $P(\bm{\theta}|\bm{d})$ or the terminology PPDF will only refer to the product $L(\bm{\theta}|\bm{d})P(\bm{\theta})$. The prior distribution represents knowledge of the parameter values before the data $\bm{d}$ is available. [When prior information is lacking, a common practice is to assume uniform distributions with parameter ranges large enough to contain all plausible values of parameters.]{} Selection of appropriate likelihood functions for a specific turbulence simulation is an open question. A commonly used *formal* likelihood function is based on the [simplistic]{} assumption that the residual term $\bm{\varepsilon}$ in follows a multivariate Gaussian distribution with mean zero and prescribed standard deviations, which leads to the Gaussian likelihood function: $$\begin{aligned} L(\bm{\theta}|\bm{d}) = \exp\left[-\frac{1}{2}(\bm{d}-\bm{f}(\bm{\theta}))^{\top} \Sigma^{-1}(\bm{d}-\bm{f}(\bm{\theta})) \right]. \label{MVN} \tag{MVN}\end{aligned}$$ In this paper, we assume that the residual errors are independent, i.e., the covariance matrix $\Sigma$ is diagonal. [To describe the correlation of the errors or the inadequacy of turbulence models, other covariance matrices can also be used (and lead to inconsistent results) [@COP+11; @OM11].]{} In general, the formal approach has been criticized for relying heavily on residual error assumptions that do not hold. Alternatively, *informal* likelihood functions are proposed as a pragmatic approach to implicitly account for errors in measurements, model inputs and model structure and to avoid over-fitting to reference data [@BB92]. Definition of informal likelihood functions is problem specific in nature, and there has been no consensus on which informal likelihood functions outperforms others. For the sake of illustration, in §\[sec:result\], the exponential informal likelihood function is used for the numerical example (together with ). It reads: $$\begin{aligned} L(\bm{\theta}|\bm{d}) = \exp\left(-\zeta \cdot \dfrac{\sum_{i=1}^{N_d} \left((d_i-f_i) - (\overline{\bm{d}}-\overline{\bm{f}})\right)^2} {\sum_{i=1}^{N_d} \left(d_i- \overline{\bm{d}}\right)^2}\right), \label{EXP} \tag{EXP}\end{aligned}$$ where $\overline{\bm{d}}$ is the mean of observations, $\overline{\bm{f}}$ is the mean of the outputs of forward model, and $\zeta$ is a scaling constant. For some other widely used informal likelihood functions, see [@SBT08]. Adaptive hierarchical sparse grid methods for construction of the surrogate PPDF -------------------------------------------------------------------------------- The central task of Bayesian inference is to estimate the posterior distribution $P(\bm{\theta}|\bm{d})$. It is often difficult to draw samples from the PPDF directly, so the MCMC methods, such as the Metropolis-Hastings (M-H) algorithm [@GL06] and its variants, are normally used for the sampling process. In practice, the convergence of MCMC methods is often slow, leading to a large number of model simulations. To tackle this challenge, surrogate modeling approaches seek to build an approximation (called the surrogate system) for $P(\bm{\theta}|\bm{d})$, then the MCMC algorithm draws samples from it directly without executing the forward model. With this approach, the main computational cost for evaluating the PPDF is now transferred to the surrogate construction step. Naturally, an approximation method which requires minimal number of grid points in the parameter space, while not surrendering much accuracy is desired. The methodology we utilize to construct the surrogate system, presented in this subsection, is similar to the method introduced in [@ZLY+13]. Since the method can be applied to functions governed by partial differential equations, not limited to $P(\bm{\theta}|\bm{d})$ or $\bm{f}(\bm{\theta})$, a generic notation $\eta(\bm{\theta}):\Omega\to \mathbb{R}$ is used for the description. The following assumptions are needed: 1. The domain $\Omega$ is a rectangle, i.e., $\Omega = \Omega_1 \times \ldots \times \Omega_{N_\theta}, $ where $\Omega_n \subset \mathbb{R},\, n= 1,\ldots, N_\theta.$ 2. The joint probability density function ${ \rho}({\bm \theta})$ is of product-type: $$\begin{aligned} { \rho}({\bm \theta}) = \prod_{n=1}^{N_{\theta}} \rho_n(\theta_n),\end{aligned}$$ where $\rho_n:\Omega_n\to \mathbb{R}$ are univariate density functions. 3. The univariate domains and density functions are identical: $$\begin{aligned} \Omega_1 = \ldots = \Omega_{N_{ \theta}};\ \rho_1 = \ldots = \rho_{N_{ \theta}},\end{aligned}$$ yielding the same $i$-level univariate quadrature rules $$\begin{aligned} \mathcal{Q}_i^{(1)}[\cdot] = \ldots = \mathcal{Q}_i^{(N_\theta)}[\cdot] =: \mathcal{Q}_i[\cdot] . \end{aligned}$$ 4. The univariate quadrature rules are nested. ### Adaptive sparse grid interpolation {#s_1dhintp} The basis of constructing the sparse grid approximation in the multi-dimensional setting is the one-dimensional (1-D) hierarchical interpolation. Consider a function $\eta(\theta): [0,1] \rightarrow \mathbb{R}$. The 1-D hierarchical Lagrange interpolation formula is defined by $$\label{1d_hintp} \mathcal{U}_K[\eta](\theta) := \sum_{i=0}^K \Delta \mathcal{U}_i[\eta](\theta),$$

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through inheritance. Story continues below advertisement It says the average inheritance received by the 50-75 age cohort over the past decade was $180,000. CIBC forecasts the average inheritance will be higher than that, due to the increased value of assets – particularly homes. "This significant wealth transfer could impact important economic variables such as wealth distribution, savings, labour market participation, start-up activity, and real estate markets," writes CIBC economist Benjamin Tal.Tips For How To Successfully Hire A Top It Employee Through A Recruitment Agency As per a recent report published by Jobvite, over 65% of companies claim talent shortage is their biggest challenge when hiring. This is especially true when it comes to specialized jobs in the IT (Information Technology) sector. 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Clearly, such recruiters can analyze an applicants technical prowess better and more successfully identify the ones most suited for your companys job requirement. – Maximum reach: In the IT sector, job changes can happen quickly. This is mainly because of the growing opportunities in this niche. Recruiters monitor new profiles regularly and can even reach out to candidates who are in what is called, the passive state. A passive candidate is open to new opportunities but not actively looking for a new job. They are unlikely to bother checking job boards and ads. Reaching out to such professionals can get you access to the best talent in the market, so you can find the right fit for a company’s IT needs. Specialist recruitment agencies can be a huge help with filling vacant positions in highly specialised fields. Click for more info. – Temporary or Full-time roles: Information technology is a dynamic field which is why many companies need IT experts on a consulting or temporary basis. 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Employee recruitment is not just about filling a vacancy in your workplace but it’s also about finding candidates who have the right skills, can merge with your company culture and perform as per expectations. Partnering with recruitment experts can ease this stress for you and help you pick the best talent quickly and more cost-effectively.Detection of sporadic cases of Norovirus infection in hospitalized children in Italy. This study was performed to investigate the role of Noroviruses (NV) in sporadic cases of acute diarrhoea among hospitalized children in Brescia Hospital. NV were the most frequently involved viruses (23.7%) and were more common in children >5 years (23/63) than in children <5 years (6/59). The majority of the NV-positive specimens belonged to genotype II (GII). The frequency of rotavirus, enteric adenovirus and astrovirus was 12.2%, 1.6% and 2.4%, respectively. Results obtained confirm the relevance of NV as a causative agent of pediatric diarrhoea and highlight the need for continued surveillance of NV to prevent and control virus spreading.Voyaging in Strange Seas: The Great Revolution in Science In 1492 Columbus set out across the Atlantic; in 1776 American colonists declared their independence. Between these two events old authorities collapsed and a new, empirical worldview had arrived, focusing now on observation, experiment and mathematical reasoning. This book takes us along on a voyage of discovery that ushered in the modern age.The following is a true story, and this situation supposedly occurred in a real courtroom. At a trial, an attorney was putting witnesses through an exacting cross-examination, and was taking great delight into forcing witnesses to admit that they did not remember every single detail of an automobile accident. While the lawyer knew that no witness has a perfect memory, he had honed a skill in exploiting minor inconsistencies and lapses of memory in order to challenge the credibility of honest witnesses. After a series of scathing cross-examinations, he was looking forward to his examination of yet another witness. "Did you actually see the accident?" he asked. The witness responded with a polite, "Yes, sir." "How far away were you when the accident happened?" "I was Thirty-four feet, seven and three quarters inches away from the point of collision." "Thirty-four feet, seven and three quarter inches?" the lawyer asked, sarcastically, "Do you expect us to believe that your memory is so good, and your sense of distance is so precise, that months after the accident you can come into court and give that type of detail?" The witness was unphased. "Sir, I had a hunch that some obnoxious, know-it-all lawyer would ask me the distance, and would try to make it seem like I was lying if I could not give an exact answer. So I got a tape measure, and measured out the exact distance A man went to a brain store to get some brain to complete a study. He sees a sign remarking on the quality of professional brain offerred at this particular brain store. He begins to question the butcher about the cost of these brains. "How much does it cost for engineer brain?" "Three dollars an ounce." "How much does it cost for programmer brain?" "Four dollars an ounce." "How much for lawyer brain?" "$1,000 an ounce." "Why is lawyer brain so much more?" "Do you know how many lawyers we had to kill to get one ounce of brain?"Girls’ Generation’s stylist, Seo Sookyung, is renowned for her talent, even winning the Style Award at the 2012 Gaon Awards. She took part in an interview with MK Fashion, talking about her life, style, and working with Girls’ Generation. “It’s been exactly 10 years this year.” She became a student under stylist Han Hyeyeon when she was barely in her 20s. She said she felt like crying, walking along the streets where her first photoshoot, which she shot carrying around a pack of clothes larger than herself, was plastered in Myeongdong. And after 10 years, she has become an “executive director”, with six assistants. Also, the celebrity she fastens buttons for with her own hands is Girls’ Generation. “People usually work as an assistant for three to four years, or there are some who don’t go independent becoming an executive director, and become a team leader. Compared to others, I went independent really early. I was lucky.” The opportunity she had to go from a trainee to a stylist, making a full-fledged business card and making her name known, was while she worked on the advertising shoot for the makeup brand, “Etude”. At that time, the official model was being changed from Song Hyegyo to Go Ara, and that was when she got her chance. She showed off all the skills she learned through various brand advertisements to her heart’s content. Even after the model was changed to Park Shinye, she was in charge of the brand’s face for three years. “Good things happened all at once. Jung Hyeyoung, who I was in charge of at the time, was becoming known as a charity angel, causing advertisements to burst in. And Shinhye’s management requested that I become an exclusive stylist, and I worked with them since ‘You’re Beautiful’.” Without measuring it with anything else, the seven years of time she spent only looking towards her job replied to her with the most valuable “Girls’ Generation”. After meeting the girls in 2011 through “The Boys”, she showed off her characteristic bright and happy-feeling styling skills, showing off a vintage, painting-like teaser, resulting in her receiving attention every day. In particular, she also presented Girls’ Generation the “fashionista” look this year. She had the girls, who were the symbols of group outfits, wear vivid jerseys, denim, kitsch, custom jewelry, and other clothes that showed off their own, individual personalities freely. Each member was able to gain an image of a fashion icon. Sooyoung, Jessica, and Seohyun became models for a handbag brand and makeup brands,

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which I dare not send to Eichhof." Bernhard made an impatient gesture, but Lothar went on: "I know what you mean. You mean that I ought to think of the future, when our positions will be so different. I ought to consider that what is all right for the future possessor of Eichhof is supreme folly for a petty lieutenant. All true and just; but why the deuce, then, did our father put me in the same regiment with yourself? and why does every one expect exactly the same from the poor lieutenant as from the eldest son and heir? and why are people so infernally stupid as not to take into account the immense difference between us?" "It was certainly unfortunate," said Bernhard, "that you joined just this regiment; no doubt you are led here into many expenses that can hardly be avoided; but still----" "Well, then, I'd better go to friend Solomon to-morrow, and try my luck with him," Lothar interrupted him. Bernhard stamped his foot impatiently. "Don't talk nonsense!" he exclaimed. "Of course I shall help you out, since, as you justly remark, I may send in extra accounts when I please; but pray listen to reason, Lothar. You know that we shall shortly cease to live here together. When I marry I can no longer place my means at your disposal as at present." "Ah, when Thea is your wife, I shall quarter myself upon you so soon as my money is gone. It usually lasts until the twentieth of the month, and then I shall ensconce myself in your happy home. But I have not thanked you yet. Indeed, old fellow, you are a brick of a brother. Then I need not pay my respects to friend Solomon to-morrow?" Meanwhile they had reached their lodgings, and, as Bernhard was putting his key in the lock, he said, "I will help you through this time, Lothar, but remember it is the last. You must learn prudence, and it is in direct opposition to my principles to encourage this perpetual getting into debt. I did not, as you know, make the laws controlling inheritance, and I cannot alter the fact that our circumstances will be very different in the future. But I say now only just what I should say were you in my place and I in yours. Every man must cut his coat according to his cloth." "And if one is a six-footer and has only a scrap of cloth, he is in a desperate case," thought Lothar; but he kept his thought to himself, and softly whistled an opera air as he entered their apartments with his brother. "It's no end of a pity that we must leave our charming quarters so soon," he sighed, as he threw himself upon a lounge in their joint drawing-room, which was certainly most luxuriously fitted up for a bachelor establishment, while Bernhard opened and read, with a smile, a letter lying upon his table. Lothar watched him for a moment, then folded his arms and raised his eyes to the ceiling, with an expression half resignation and half disdain, while his thoughts ran somewhat thus: "Of course that is a letter from Thea. What under the sun can that little country girl have to say to him? A deuced pretty girl, and she'll make a capital wife. It's very odd that I'm not angry with her, for there's not another creature in the world so confoundedly in my way. If it were not for her, we should keep our comfortable lodgings, and Bernhard, who is certainly a trump, would go on paying my bills; and, besides, he has grown so infernally serious since he has had that little witch's betrothal-ring on his finger; before then we lived a jolly life enough. It is all Thea's fault,--his immense gravity, his ceasing to pay my debts, and our having to give up our delightful rooms. It is, therefore, Thea who prevents my enjoying my youth, as I should do otherwise, and yet, in spite of all this, I am rather fond of her. But it is not my nature to bear malice towards any woman, even although she be such an unformed little country girl as Thea, who certainly might have been content to wait a few years longer." "Bernhard," he suddenly said aloud, "I will withdraw to my inmost apartment, and leave you to your letter and to dreams of future petticoat rule." Bernhard put his letter in his pocket. "I have finished," he said, "and am going to bed. Thea sends her love to you." "Of course," yawned Lothar; "thanks. We'll talk about the other matter to-morrow?" "Yes. Good-night, Lothar." "Good-night, old fellow." CHAPTER II. TWO DISCONTENTED FATHERS. A forest bridle-path. The ground is covered with gnarled, twisted roots, and the way is bordered with dark pines, and firs somewhat lighter in tone, between which only a narrow strip of spring sky shines down upon the two riders pursuing the dim pathway. Their horses, slowly walking abreast, seem by no means content to saunter thus; the chestnut upon which the man is mounted champs its bit impatiently, and the gray by its side pricks its ears, but the girl upon the back of the latter is as interested as her companion in the conversation going on between them, and neither pays any heed to the signs of their steeds' impatience, while the groom riding at some distance behind them is enjoying a huge sandwich that he has produced from his pocket, in full security from observation. "It is too vexatious to know nothing about it all!" the girl exclaimed. "I am almost ashamed never to have been in Berlin." "But, good heavens, you are so young, Adela!" her companion rejoined. "If we are to continue friends, Walter, you will not begin again about my fifteen years, of which there can be no further mention after next month, when I shall be sixteen," was the irritated reply. "I am in reality much, much older, as you know, and I know that I look older. Only the other day Lieutenant Muellheim took me for eighteen; and if papa would only allow me to dress suitably, and if it were not for that stupid Almanach de Gotha that tells everybody our ages----!" She sighed pathetically. Walter laughed. "That sigh would sound more natural from the lips of a lady past her prime than from those of a budding girl in her teens," he said; adding instantly, with a meaning glance at his companion, "You must not look so angry with me, Adela dear. If you refuse to allow me more license in speaking than you accord to the rest of the world, I shall address you as Fraeulein von Hohenstein and think all our good-comradeship at an end. Must I do so? In fact, you certainly are too much of a great lady to be my 'good comrade' any longer." He spoke without irony, and there was a mournful earnestness in his fine eyes. She gave her horse a light cut with her whip, that his sudden start might give her the chance to conceal the bright blush that overspread her face. Then she looked up, half pouting, half in entreaty, and said, "If you want to tease me, Walter, I can't see why you came for me to ride; you might as well have stayed at home." Walter smiled, and saluted with his riding-whip. "Well, then, let us be good comrades for the future, as neighbors' children ought to be," he cried. Her reply was a merry glance from her blue eyes. They had reached the borders of the forest, and before them a well-kept road, bordered by fine old trees, led directly up to an imposing pile of buildings. "Let us have one more canter," said Adela; and away flew the two horses so suddenly that the groom behind them was, in his surprise, nearly choked by his last mouthful of sandwich, and followed his mistress coughing and gasping all the way up the avenue to the court-yard, where the two riders drew rein. "It has really grown so late that I cannot come in with you," said Walter. "I must hurry home; you know we are terribly punctual about our meals at Eichhof." "Well, then, good-by; for only a short time, I hope," said Adela, giving her comrade her hand, and then vanishing with the groom behind the court-yard gate, while Walter took the road to Eichhof. He was the third and youngest son of the

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the proof of Theorem \[th-1.7\]. We can also establish the following assertion. \[th-4.3\] Assume that the heat kernel $p_t(\cdot,\cdot)$ satisfies [**(A1)**]{} and the measure $\mu$ satisfies (\[eq1.3\]). For $b>0$ and $T>0$, let $r_{0}=b\beta^{\star}/2\alpha$, $I=[0,T)$. Assume that $r\geq r_{0}>1$ and that $(q,p,r)$ is a generalized admissible triplet satisfying $p>b+1$. - If $f\in C_{q/(b+1)}(I; L^{p/(b+1)})$, then for $p<r(b+1)$, $$\|G(f)\|_{L^{\infty}(I; L^{r})}\leq T^{1-b\beta^{\star}/2r\alpha}\|f\|_{C_{q/(b+1)}(I; L^{p/(b+1)})}.$$ For $p\geq r(b+1)$ and $\theta=[p-r(b+1)]/(b+1)(p-r)$, $$\|G(f)\|_{L^{\infty}(I; L^{r})}\leq CT^{1-b\beta^{\star}/2r\alpha}\||f|^{1/(b+1)}\|^{\theta(b+1)}_{L^{\infty}(I; L^{r})} \||f|^{1/(b+1)}\|^{(1-\theta)(b+1)}_{C_{q}(I; L^{p})}.$$ - If $f\in C_{q/(b+1)}(I; L^{p/(b+1)})$, then for $p<r(b+1)$, $$\|G(f)\|_{C_{q}(I; L^{p})}\leq T^{1-b\beta^{\star}/2r\alpha}\|f\|_{C_{q/(b+1)}(I; L^{p/(b+1)})}.$$ For $p\geq r(b+1)$ and $\theta=[p-r(b+1)]/(b+1)(p-r)$, $$\|G(f)\|_{C_{q}(I; L^{p})}\lesssim T^{1-b\beta^{\star}/2r\alpha}\||f|^{1/(b+1)}\|^{\theta(b+1)}_{L^{\infty}(I; L^{r})} \||f|^{1/(b+1)}\|^{(1-\theta)(b+1)}_{C_{q}(I; L^{p})}.$$ \(i) For the case $p<r(b+1)$, we use Lemma \[le-4.1\] to derive $$\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\|_{L^{r}(\mathbb{M})}\lesssim (t-s)^{-\beta^{\star}[(b+1)/p-1/r]/2\alpha}\|f(s,\cdot)\|_{L^{p/(b+1)}(\mathbb{M})},$$ thereby getting $$\begin{aligned} &\|G(f)\|_{L^{\infty}(I; L^{r})}\\ &\ =\sup_{t\in[0,T)}\|G(f)\|_{L^{r}(\mathbb{M})}\\ &\ \leq\sup_{t\in[0,T)}\int^{t}_{0}\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\|_{L^{r}(\mathbb{M})}ds\\ &\ \lesssim \sup_{t\in[0,T)}\int^{t}_{0}(t-s)^{-\beta^{\star}[(b+1)/p-1/r]/2\alpha}\|f(s,\cdot)\|_{L^{p/(b+1)}(\mathbb{M})}ds\\ &\ \lesssim \|f\|_{C_{q/(b+1)}(I; L^{p/(b+1)})}\sup_{t\in[0,T)}\int^{t}_{0}(t-s)^{-\beta^{\star}[(b+1)/p-1/r]/2\alpha}s^{-(b+1)/q}ds\\ &\ \lesssim \|f\|_{C_{q/(b+1)}(I; L^{p/(b+1)})}\sup_{t\in[0,T)}t^{1-b\beta^{\star}/2\alpha r}\int^{1}_{0}\frac{u^{-(b+1)/q}}{(1-u)^{\beta^{\star}[(b+1)/p-1/r]}}du\\ &\ \lesssim T^{1-b\beta^{\star}/2\alpha r}\|f\|_{C_{q/(b+1)}(I; L^{p/(b+1)})}.\end{aligned}$$ Next we consider the case $p\geq r(b+1)$. Lemma \[le-4.1\] implies $$\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\|_{L^{r}(\mathbb{M})}\leq C\|f(s,\cdot)\|_{L^{r}(\mathbb{M})}.$$ If $$\begin{cases} &\theta\in (0,1);\\ &r(b+1)\theta p'=r;\\ &r(b+1)(1-\theta)q'=p;\\ &1/p'+1/q'=1, \end{cases}$$ then $$\theta=[p-r(b+1)]/(p-r),$$ and hence Hölder’s inequality is used to derive $$\begin{aligned} &\|G(f)\|_{L^{\infty}(I; L^{r})}\\ &\ \leq\sup_{t\in [0,T)}\int^{t}_{0}\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\|_{L^{r}(\mathbb{M})}ds\\ &\ \lesssim \sup_{t\in [0,T)}\int^{t}_{0}\|f(s,\cdot)\|_{L^{r}(\mathbb{M})}ds\\ &\ =\sup_{t\in [0,T)}\int^{t}_{0}\left\||f(s,\cdot)|^{1/(b+1)}\right\|_{L^{r(b+1)}(\mathbb{M})}ds\\ &\ =\sup_{t\in [0,T)}\int^{t}_{0}\left\||f(s,\cdot)|^{1/(b+1)}\right\|^{\theta(b+1)}_{L^{r}(\mathbb{M})}\left\||f(s,\cdot)|^{1/(b+1)}\right\|^{(b+1)(1-\theta)}_{L^{p}(\mathbb{M})}ds\\ &\ \lesssim \left\||f|^{1/(b+1)}\right\|^{\theta(b+1)}_{L^{\infty}(I; L^{r})}\left\||f(s,\cdot)|^{1/(b+1)}\right\|^{(b+1)(1-\theta)}_{C_{q}(I;L^{p})}\\ &\ \ \ \times \Big(\sup_{t\in [0,T)}\int^{t}_{0}s^{-(b+1)(1-\theta)/q}ds\Big)\\ &\lesssim T^{1-\beta^{\star} b/2\alpha r}\left\||f|^{1/(b+1)}\right\|^{\theta(b+1)}_{L^{\infty}(I; L^{r})}\left\||f(s,\cdot)|^{1/(b+1)}\right\|^{(b+1)(1-\theta)}_{C_{q}(I;L^{p})}.\end{aligned}$$ Finally, we begin to prove (ii). Suppose $$f\in C_{q/(b+1)}(I; L^{p/(b+1)}).$$ For the case $p<r(b+1)$, we use Lemma \[le-4.1\] to obtain $$\left\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\right\|_{L^{p}(\mathbb{M})}\leq C(t-s)^{-\beta^{\star}[(b+1)/p-1/p]/2\alpha}\left\|f(s,\cdot)\right\|_{L^{p/(b+1)}(\mathbb{M})}.$$ Then a direct computation gives $$\begin{aligned} &\|G(f)\|_{C_{q}(I; L^{p})}\\ &\ :=\sup_{t\in [0,T)}t^{1/q}\|G(f)\|_{L^{p}(\mathbb{M})}\\ &\ \leq\sup_{t\in [0,T)}t^{1/q}\left\|\int^{t}_{0}e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)ds\right\|_{L^{p}(\mathbb{M})}\\ &\ \leq\sup_{t\in [0,T)}t^{1/q}\int^{t}_{0}\left\|e^{-(t-s){\mathcal{L}}^{\alpha}}f(s,\cdot)\right\|_{L^{p}(\mathbb{M})}ds\\ &\ \leq\sup_{t\in [0,T)}t^{1/q}\int^{t}_{0}(t-s)^{-\beta^{\star}[(b+1)/p-1/p]/2\alpha}\left\|

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Pain Society (the organizer for #WCAPP17). So, needless to say, she has an impressive resume and a passion for understanding pelvic pain. Just check out her wrap sheet. I’ve chosen a few interesting nuggets from her lecture. Each of these camps have their own combination of modifiers that can lead to sensitization. Pause- so this is where one can get overloaded with information, so I took some creative liberties and decided to draw a picture. As you see from the drawing, there are several areas where our brain and our body can modify signals related to pain. At the “nociceptor sensitization camp” the sensory nerves can become extra excited, and maybe throw too much input into the nervous system. For example, do you remember the last sunburn you had? Remember how sensitive your skin was- even the slightest touch was immensely painful. Well, now imagine that you don’t have a sunburn but your nerves are sending that same intense signal, as if your tissue was still burned. This nervous system mix up is called allodynia, when normally non-painful stimulus is extremely painful. At the “stream of spinal central sensitization” the spinal cord can send information upstream, to the brain, or downstream, to the peripheral nerve, to modify signals related to pain. For example, #1 on the list, prolonged dorsal horn firing, is similar to an echo. This is when your hand-nerve yells “watch out” to your spinal cord, and your spinal cord yells to your brain “watch out….watch out….watch out….watch out….watch out… watch out…watch out….” well you get the idea. A single signal potentiates into multiple. Finally we have the “lake of cortical reorganization”, or in layman’s terms, brain change. Here you can have tidepools of emotional distress or reefs of prior history or insert another water-based metaphor here. Essentially, upcoming signals are then interpreted within the framework of the brain where it decides if it’s enough to produce a pain response. How this all works is a bit murky, pardon the pun, but we do know that our interpretation of nociceptive signals greatly impacts how the brain choose to deal with them. Somatic vs. Visceral: Crosstalk Dr. Farmer also touched on the differences between somatic and visceral pain and the crosstalk that can occur between the two. When comparing sensations from somatic (aka your body) and visceral structures (aka your organs), there are several differences. Somatic pain has a distinct quality, like a sharp or pinching sensation. It correlates specifically to the intensity, duration and location of the stimulus and is caused by tissue injury and inflammation. One easy example of somatic pain is the ankle pain one might experience following a sprain. Conversely, visceral pain is diffuse in quality and generally is found along the midline of the body. It doesn’t have the same on/off switch and tends to correlate very poorly with its stimulus. Just think how you felt the last time you had food poisoning…yah not fun. Okay, that seems reasonable, now we have some ways to separate out different types of pain. However, sometimes messages can get muddled when somatic and visceral structures start to talk to one another – called crosstalk. This can happen when sensory fibers of pelvic organs synapse close by where other somatic or visceral structures synapse at the spinal cord. You can see how it can get confusing when a problem in one organ might feel like a problem in a completely separate organ or body part. One case of this is viscero-somatic pain, when a visceral structure creates body pain. A well-known example of viscero-somatic pain is when during a heart attack someone might report significant left arm pain. In the pelvis however, this would look like a patient complaining of low back pain when the stimulus is actually coming from uterine contractions. This crosstalk can also go the opposite direction, somato-visceral pain. This could happen with vulvar inflammation. A patient may have multiple yeast infections leading to inflammation of the vulva (somato-), but then also experience bladder pain (visceral). And it doesn’t stop there. Viscero-visceral pain, yup that happens. Stimulus from one organ can be confused with stimulus from another organ. This can even lead to changes in how the organs function. This type of viscero-visceral pain is one explanation for the high prevalence of irritable bowel syndrome in women with endometriosis. What does this mean for patients? So now what? All of this can be quite overwhelming. It’s important for both patient and practitioners to educate themselves regarding the different facets of pain. Great resources including Dr. Farmer’s research and books like Explain Pain or Pelvic Pain Explained can be very helpful in help navigating these uncertain waters. Since knowledge is power, the more we understand the cause, the better we can treat pain together. Thank you again for the enlightening presentation Dr. Farmer! If you want to check out the whole presentation, which we recommend, look here.Tri City Rentals Partners with American Red Cross and the City of Albany to Support Swim Program! 7/21/2014 10:06:16 AM On Wednesday, July 9th, 2014 Tri City Rentals, American Red Cross Northeastern New York, and the City of Albany partnered together to kick off this year’s Learn-to-Swim Program at Lincoln Park Pool in Albany, NY.University community turns out to share feedback on draft strategic plan Khaled Keshk, associate professor and chair of Religious Studies, comments during a town hall meeting to discuss a draft of the university's strategic plan. (DePaul University/Jeff Carrion) Two town hall meetings soliciting feedback on the draft strategic plan attracted standing room only crowds, demonstrating the investment faculty, staff and students are making in envisioning DePaul's future. Forum participants affirmed the Board of Trustees' call to give mission strategies their own goal, arguing mission is what distinguishes DePaul and should be seen as what informs all other goals. Requests also were made to elaborate on how DePaul's Catholic and Vincentian identity should be further institutionalized as the number of religious Vincentians available to reinforce that identity diminishes. "The university has discussed catholic with a small c - meaning universal, open and inclusive - but Catholic with a capital C does not mean the opposite," says Mark Laboe, associate vice president for Mission and Ministry. "We have to be more clear about what we mean by Catholic." The intrinsic value of the liberal arts and the organization of technology services to accomplish the university's business and enhance academic programs and student services were among the top topics of conversation. Meanwhile, comments about the student experience were wide-ranging. Several people noted that students suffer by being "bounced around" when there is a lack of knowledge about what individual departments do or poor communication between units. Ensuring appropriate student support services in new programs was another concern. There was a request for more evening and weekend courses for undergraduates and non-traditional students, such as working parents, who cannot take daytime classes. Although online enrollment is growing fast, the university was cautioned about offering certain classes and programs exclusively online because students using veteran benefits cannot be reimbursed for expenses related to online offerings. Jay Braatz, vice president for strategic planning and presidential administration, chairs the representative Strategic Planning Task Force that assembled the draft plan. She noted that it is the board's responsibility to establish the university's strategic direction based on conditions prevailing in the higher education landscape. She also noted that the board does not do its work in a vacuum, but relies on the wisdom and input of the university community. "Once strategic direction is set," she says. "It is the job of the university community to implement the plan. It will be up to us to determine what steps we need to take to reach the plan's goals and objectives." Several applauded the inclusion of an objective to develop students' global citizenry, one participant noting the importance of speaking another language "as a pre-requisite for true cultural agility," and another indicating that religious competency is a critical skill to navigate many cultures around the world. Diversity strategies attracted comments that touched many corners of the university, from the necessity of people in positions of privilege to become more inclusive of historically marginalized communities to ensuring that an increase in diversity among employees should include hiring in positions of power. A number of staff members said they felt the role professional staff needed to be articulated more forcefully, particularly since staff will have a major role in achieving the proposed goals. Faculty requested acknowledgement of the increase in contingent faculty and the roles that different types of faculty play. A summary of themes from the town halls can be found here. "Many times, what the church teaches and believes comes from the ground up. They were practicing it and living it, and it was part of their reality. Then it became formalized in the church structure," he noted in closing the session. "My sense is that you are living the Catholic, Vincentian mission. You are part of this university, and from your experience will come a strategic plan that we can look at and say 'that is who we are' because that's what we are doing."Course Description: In this course, practical experience in solo and ensemble instrumental performance is offered. The required performance level for entry into this course is left to the discretion of the instructor. This course is the second of the sequence: MUS 153, MUS 154, MUS 253, and MUS 254. Course Goals: Upon successful completion of this course, students should be able to do

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. Small Material Vibrator Feeder, Wholesale Various High Quality Small Material Vibrator Feeder Products from Global Small Material Vibrator Feeder Suppliers and Small Material Vibrator Feeder Factory,Importer,Exporter at .-- +migrate Up ALTER TABLE hydra_client ADD frontchannel_logout_uri TEXT NULL; ALTER TABLE hydra_client ADD frontchannel_logout_session_required BOOL NOT NULL DEFAULT FALSE; ALTER TABLE hydra_client ADD post_logout_redirect_uris TEXT NULL; ALTER TABLE hydra_client ADD backchannel_logout_uri TEXT NULL; ALTER TABLE hydra_client ADD backchannel_logout_session_required BOOL NOT NULL DEFAULT FALSE; UPDATE hydra_client SET frontchannel_logout_uri='',post_logout_redirect_uris='',backchannel_logout_uri=''; ALTER TABLE hydra_client MODIFY frontchannel_logout_uri TEXT NOT NULL; ALTER TABLE hydra_client MODIFY post_logout_redirect_uris TEXT NOT NULL; ALTER TABLE hydra_client MODIFY backchannel_logout_uri TEXT NOT NULL; -- +migrate Down ALTER TABLE hydra_client DROP COLUMN frontchannel_logout_uri; ALTER TABLE hydra_client DROP COLUMN frontchannel_logout_session_required; ALTER TABLE hydra_client DROP COLUMN post_logout_redirect_uris; ALTER TABLE hydra_client DROP COLUMN backchannel_logout_uri; ALTER TABLE hydra_client DROP COLUMN backchannel_logout_session_required; THIS IS NASA'S RESPONSE TO ANONYMOUS' ALIEN DISCLOSURE CLAIM When the online collectivist group Anonymous released a new video this week claiming that the space agency NASA was imminently about to announce the discovery of extra-terrestrial life in this universe, it generated a huge amount of excitement for space watchers all over the world. Unfortunately, according to the space agency, the claims made by Anonymous in this viral video is simply incorrect. NASA CLAIMS THAT ANONYMOUS’S ALIEN ANNOUNCEMENT VIDEO IS FALSE "Contrary to some reports, there's no pending announcement from NASA regarding extraterrestrial life, "said Robert Zurbuchen, NASA associate administrator for science in a tweet published this week, putting an end to the speculation that the space agency was on the cusp of making a major announcement about the discovery of extra-terrestrial life. “Control oil and you control nations; control food and you control the people.”Henry Kissinger “once a standing army is established, in any country, the people lose their liberty.”George Mason “Military men are dumb, stupid animals to be used as pawns for foreign policy.”Henry Kissinger “If you are an ordinary person, then you can prepare yourself for war by moving to the countryside and building a farm, but you must take guns with you, as the hordes of starving will be roaming. Also, even though the elite will have their safe havens and specialist shelters, they must be just as careful during the war as the ordinary civilians, because their shelters can still be compromised.”Henry Kissinger "We don't let them have ideas. Why would we let them have guns?" Joseph Stalin The people who cast the votes decide nothing. The people who count the votes decide everything.Joseph Stalin Governments keep a lot of secrets from their people . . .Why aren't the people in return allowed to keep secretsfrom the government?PHILIP ZIMMERMAN, DER SPIEGEL“Some call it Communism, I call it Judaism.” Rabbi Stephen Weiss “Anti-Communism is Anti-Semitism.” Jewish Voice, July - August 1941 Taxing People is Punishing SuccessUNKNOWN There's the rich, the poor, and the tax payers...also known as the middle class.Robert Kiyosaki ‏ The Tax you pay is The Bill for Staying StupidStefan Molyneux “The modern banking system manufactures money out of nothing. The process is, perhaps, the most astounding piece of sleight of hand that was ever invented. Banks can in fact inflate, mint and un-mint the modern ledger-entry currency.” Major L L B Angus The few who understand the system will either be so interested in its profits or so dependent on its favours that there will be no opposition from that class, while on the other hand, the great body of the people mentally incapable of comprehending the tremendous advantage that capital derives from the system will bear its burdens without complaint and perhaps without even suspecting that the system is inimical to their interests.The Rothschild Bros "Debts must be collected, bonds and mortgages must be foreclosed as rapidly as possible. When, through a process of law, the common people lose their homes they will become more docile and more easily governed through the influence of the strong arm of government, applied by a central power of wealth under control of leading financiers. This truth is well known among our principal men now engaged in forming an imperialism of Capital to govern the world. By dividing the voters through the political party system, we can get them to expend their energies in fighting over questions of no importance. Thus by discreet action we can secure for ourselves what has been so well planned and so successfully accomplished." USA Banker's Magazine, August 25 1924 Cutting Tax Rates stimulates Economic Growth creates more Profit , more Jobs and therefore The Treasury ends up with more Tax Money UNKNOWN Taxation is legalized Theft UNKNOWN "The Objective of the Bank is not the control of a conflict , it's the control of the debt that a conflict produces . The real value of a conflict , the true value is in the debt that it creates . You control the debt , you control everything . this is THE VERY ESSENCE OF THE BANKING INDUSTRY , to make us all , whether we be nations or individuals , SLAVES TO DEBT " An UNKNOWN Banker Patriotism is the last refuge... to which the scoundrel clings .... Steal a little and they throw you in jail ..steal a lot and they make you king .... Bob Dylan "Corporations are stealing billions in tax breaks, while the confused, screwed citizenry turn on each other. International corporations have no national allegiance, they care only for profit." Robert Reich There is NO political answer to a spiritual problem!Steve Quayle Political Correctness is a Political Stand Point that does not allow Political Opposition , This is actually The Definition of Dictatorship Gilad Atzmon The modern definition of racist is someone who is winning an argument with a liberalPeter Brimelow When People lose everything and have nothing left to lose , They Lose It ! GERALD CELENTE Your Greatest Teacher is Your Last Mistake DAVID ICKE The one who Controls the Education System , Controls PerceptionUNKNOWN "The world will not be destroyed by those who do evil, but by those who watch them without doing anything." Albert Einstein Receive These Posts by Email: Search This Blog Let me tell you why you're here. You're here because you know something. What you know you can't explain, but you feel it. You've felt it your entire life, that there's something wrong with the world. You don't know what it is, but it's there, like a splinter in your mind, driving you mad. It is this feeling that has brought you to me. Do you know what I'm talking about? Morpheus The Matrix 1999 No man escapes when freedom fails; The best men rot in filthy jails. And those that cried 'Appease! Appease!' Are hanged by those they tried to pleaseUNKNOWN Freedom is not FreeUNKNOWN Don't Steal The Government Hates The CompetitionRon Paul "Buy The Rumor , Sell The Fact "Peter Schiff You can love your Country and not your Government Jesse Ventura " The Government Works for ME , I do not answer to them They Answer to ME "Glenn Beck "Tyranny will Come to Your Door in a Uniform "Alex Jones "The Government is not The Solution to our Problems , The Government is The Problem "Ronald Reagan "The price good men pay for indifference to public affairs is to be ruled by evil men."Plato The world is a tragedy to those that feel, and a comedy to those that think...Beppe Grillo "The people should not fear the government for it is the government who should fear the people"UNKNOWN "If You are looking for solutions to the world's problems , look in the Mirror , You Are The Solution , You have the power as a human being on this planet " UNKNOWN "They don't control us , We empower them " UNKNOWN "Serial Killers do on a Small Scale What Governments do on a large one..." Serial Killer Richard Ramirez There is a Class War going on in America, & unfortunately, my class is winning."Warren Buffet

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disappointment. Hanshaw says she feels both she and her dead son have been unjustly vilified in the press over the last few days. For the first time during our chat, there is an edge of anger in her voice. "I know people are blaming me and I know people are blaming him, but what I say is – you don't know me, and you didn't know my son. I did my best for him, just like any other mother. Yes, his dad and I split up, but we're still friends, he's been down here this week. It wasn't the worst break-up." One of the things that has hurt her most has been that some people have said that it was right that her son wasn't deemed eligible for the liver transplant that might have saved his life. "I've heard people have said that reading about Gal makes them feel like ripping up their donor cards. Well, rip them up! We wouldn't want a liver from anyone like them anyway." She pauses. "At the end of the day, I'm just a mum who was trying to keep her child alive. You'd do anything … I'd do anything …" She had heard that a transplant would have given Gary a 75% chance of recovery. She did all she could for him in what turned out to be his final weeks. "I was at the hospital every day." Now, she says, she'd just like other mothers, and other young people like Gary, to know the reality of heavy drinking. "If they could have seen my Gary lying there, so ill and so swollen … if they could have heard how much he wanted to live. If I'd known then what I know now I'd have done something, anything, to stop him drinking but I didn't know it could turn out this bad. And I didn't know how to stop it." How to stop young alcoholism is the $64,000 question: and according to Sheron the answer, like the problem, is multifactorial. "There isn't one single reason for it, and there isn't one single solution to it," he says. One thing he will be pinned down on is cheap alcohol marketed directly at young people. "We've got to look at the fact that there are almost no controls on this," he says. "It's being pushed through the internet, through mobile phones, through all channels." But for Gary Reinbach, there was to be no second chance. "I'm not saying he was the perfect son," says his mother. "But I'll tell you this: he didn't deserve to die like that, at 22. No one does. And I hope to goodness others learn from it, because I don't want any other mother to go through what I'm going through."Rocky Cut Me, Mick Tee Rocky is in the 15th and final round of his brutal heavyweight championship bout against Apollo Creed. Rocky can't see nuthin'. He tells his trainer, Mickey, "You gotta open my eye". Open your eye in this ring-spun slub jersey. Contenders don't quit!Q: Qt Installer кириллица в пути Сделал инсталятор с Qt Installer, вроде бы всё нормально, но в пути для каталога установки, если попадается кириллица - выводится ошибка. Для меня понятна, а пользователей ввергает в иррациональный ужас и панику, так как пишет, что мол найден символ не относящийся к ANCII, выберите другую папку. Нельзя ли убрать это ограничение или хотя бы изменить текст этой ошибки. A: Простите дурака, не заметил сразу в документации. В одном из примеров сейчас наткнулся на такую строчку в конфиге. <AllowNonAsciiCharacters>true</AllowNonAsciiCharacters> Vicar prays for end to St Thomas’ Church Hall saga HOPING: The Rev Stephen Grey at St Thomas' Church Hall A vicar is praying for an end to a planning wrangle which has held up the creation of a new community hall for at least two years. The Rev Stephen Grey is hoping Wyre planning committee will finally grant full planning permission for St Thomas’ Church Hall to be revamped into four homes, together with the creation of another home on the car park. Once permission is granted, the site, on Church Street, Garstang, can be sold to developers, and the cash can be used to finish the shell of a new church hall down the road in the vicarage garden. “This has been going on for years,” said Rev Grey. “One of the problems has been that there are various parties involved. We want to keep the facade of the hall, and the other plot earmarked for a house would be left for use as a car park. “I understand the full planning application will be considered on March 6 by the planning committee,” said Rev Grey. “I really hope this will be the end of it, and that we can move on and create a new community hall for use by people in Garstang. “The old hall has served the community as school and hall since 1845 and we wish to continue that service with the new. We already have organisations queueing to use it. There has been massive support from local people, with more than 50 letters of support, and I would like to say a big thank you.”Frat raises over $5K in fundraising Hang on for a minute...we're trying to find some more stories you might like. Email This Story Send email to this addressEnter Your NameAdd a comment hereVerification The recent loss of a fraternity brother inspired an idea for Sigma Phi Epsilon, to focus their fall philanthropy event on epilepsy awareness. Epilepsy awareness lasted a full week; SigEp surpassed their goal of raising $3,000 in the first night. Totaling to over $5,000, SigEp raised more than they ever have toward their philanthropy, said junior nursing major and SigEp president, Billy Enderle. Ryan Hall, senior electronic media and broadcasting major and community service and philanthropy chair for the fraternity, headed epilepsy awareness week. The bombshell of the week was the date auction on Oct. 1. “I said we’d be lucky to make $1,000,” Enderle said. “We beat that within the first ten guys which was exciting.” The date auction featured about 30 members of SigEp who were auctioned off based on the credentials they had set for a date to take one woman on. “We didn’t know how well it would work, we were just kind of testing the waters,” Enderle said. “It was surreal. It took a lot of stress off of the remainder of the week,” he said. Hall explained the date auction brought him to tears. “Eric Schuler and I were emceeing the event and I stepped off stage to check the tally of how much we had raised so far, someone stopped me and said, ‘Ryan, we have raised $1,500,’ I teared up and had to get back on stage after that,” he said. Enderle said this event was a real “morale booster” with Chaz Edwards and Holdan Markland being names to mention in terms of bids received. Edwards went up on stage last but he was not least, receiving the highest bid of the night at $370. “I was in shock the bid ending up being that much,” Edwards said. “I didn’t know what to expect at first, I went in flying blind.” Edwards was bought by the women of Phi Sigma Sigma as a chapter. Edwards admitted that unlike the majority of the guys who had planned dates like picnics and taking a woman out to the dinner of her choice, he didn’t have much of a plan going up on stage. His finale on stage was removing his shirt. Other events throughout the week included a Dine to Donate at Applebee’s Sept. 30-Oct. 7, two-week long penny wars, a dodgeball tournament with Theta Phi Alpha, the opportunity to paint a SigEp purple and a vigil. The vigil was held on the Griffin Hall lawn and was held mostly for those who knew Evan Draper, but all those who are affected by epilepsy in some form were invited. Cathy Schragg with the Epilepsy Foundation of Greater Cincinnati played an imperative role throughout epilepsy awareness week, Hall expressed. He said she was very supportive, providing the fraternity with resources to help with fundraising, including purple bracelets that read, “seize hope.” According to the foundation, “Epilepsy is a medical condition that produces seizures affecting a variety of mental and physical functions. When a person has two or more unprovoked seizures, they are considered to have epilepsy.” Draper had been coping with his condition since mid-high school, Hall said. The NKU chapter of Sig Ep hopes to adopt this as their philanth

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at each step, averaged over the thirty MD runs for both systems. The error bars show the standard deviation of these mean values (only 80 values are here presented in order to enhance graphical clearness).](JBP2012-642745.002){#fig2} ![Histogram representation of the mechanical work, both for the system in presence (black bars) and absence (red bars) of the HSA complex. The continuous lines are the Gaussian distributions for the corresponding values of standard deviation and mean value for each histogram population.](JBP2012-642745.003){#fig3} ###### Charge distribution used for every atom in the construction of the Aspirin and Myristic Acid topologies, respectively. ###### $a$ ------------------------------------------------------ Atom\ Atom\ Name Charge\ Partial\ Mass number Type group Charge -------- ------- ------ --------- ---------- --------- 1 OM OL 1 −0.635 15.9994 2 C CK 1 0.27 12.011 3 OM OM 1 −0.635 15.9994 4 C CJ 2 0 12.011 5 CR1 CI 2 0 13.019 6 CR1 CH 2 0 13.019 7 CR1 CG 3 0 13.019 8 CR1 CF 3 0 13.019 9 C CE 3 0 12.011 10 OA OD 4 0 15.9994 11 C CB 4 0.38 12.011 12 O OC 4 −0.38 15.9994 13 CH3 CA 5 0 15.035 ------------------------------------------------------ ###### $b$ ------------------------------------------------------ Atom\ Atom\ Name Charge\ Partial\ Mass number Type group Charge -------- ------- ------ --------- ---------- --------- 1 OM OB 1 −0.635 15.9994 2 C CA 1 0.27 12.011 3 OM OC 1 −0.635 15.9994 4 CH2 CD 2 0 14.027 5 CH2 CE 2 0 14.027 6 CH2 CF 2 0 14.027 7 CH2 CG 2 0 14.027 8 CH2 CH 2 0 14.027 9 CH2 CI 2 0 14.027 10 CH2 CJ 2 0 14.027 11 CH2 CK 2 0 14.027 12 CH2 CL 2 0 14.027 13 CH2 CM 2 0 14.027 14 CH2 CN 2 0 14.027 15 CH2 CO 2 0 14.027 16 CH3 CP 2 0 15.035 ------------------------------------------------------ [^1]: Academic Editor: Claudio M. Soares Assessment of trace elements levels in patients with Type 2 diabetes using multivariate statistical analysis. The trace elements metabolism has been reported to possess specific roles in the pathogenesis and progress of diabetes mellitus. Due to the continuous increase in the population of patients with Type 2 diabetes (T2D), this study aims to assess the levels and inter-relationships of fast blood glucose (FBG) and serum trace elements in Type 2 diabetic patients. This study was conducted on 40 Egyptian Type 2 diabetic patients and 36 healthy volunteers (Hospital of Tanta University, Tanta, Egypt). The blood serum was digested and then used to determine the levels of 24 trace elements using an inductive coupled plasma mass spectroscopy (ICP-MS). Multivariate statistical analysis depended on correlation coefficient, cluster analysis (CA) and principal component analysis (PCA), were used to analysis the data. The results exhibited significant changes in FBG and eight of trace elements, Zn, Cu, Se, Fe, Mn, Cr, Mg, and As, levels in the blood serum of Type 2 diabetic patients relative to those of healthy controls. The statistical analyses using multivariate statistical techniques were obvious in the reduction of the experimental variables, and grouping the trace elements in patients into three clusters. The application of PCA revealed a distinct difference in associations of trace elements and their clustering patterns in control and patients group in particular for Mg, Fe, Cu, and Zn that appeared to be the most crucial factors which related with Type 2 diabetes. Therefore, on the basis of this study, the contributors of trace elements content in Type 2 diabetic patients can be determine and specify with correlation relationship and multivariate statistical analysis, which confirm that the alteration of some essential trace metals may play a role in the development of diabetes mellitus.Q: How to analyse LINQ queries I swear I've seen how to do this before, but now that I actually need to do it I can't remember where I saw it at. I need two different things -- 1) to see the actual SQL query that is generated by a LINQ query and 2) when the SQL query actually hits the database to do whatever (CRUD operations) Is there a tool that will allow me to do this? EDIT: Sorry, should have given more detail. -- LINQ to Entities is what I'm using. -- Also, I don't have admin rights on our instance of SQL Server, so I can't use SQL Profiler. I could always call the DBA and have them do it for me, but it's a hassle. I should have mentioned that and I apologize. What I really want is a tool that I can use on my own box that will allow me to see when a LINQ query hits the database while I am in debug mode (debugging and stepping through the code). A: Try using SQL Profiler. It's great for seeing what LINQ to SQL is generating. SQL Profiler is a graphical tool that allows system administrators to monitor events in an instance of Microsoft® SQL Server™. You can capture and save data about each event to a file or SQL Server table to analyze later. For example, you can monitor a production environment to see which stored procedures are hampering performance by executing too slowly. LINQPad is also a great tool for writing linq and sql statements for testing. LINQPad compiles your queries using .NET's CSharpCodeProvider (or VBCodeProvider). Because C# and VB are statically typed, any database objects that you reference need the backing of a typed DataContext. For performance, LINQPad builds typed DataContexts on the fly using Reflection.Emit rather than generating and compiling source code. It uses LINQ to SQL rather than Entity Framework because LINQ to SQL is an order of magnitude faster in building the metamodel when instantiated. A: The .ToString() on the IQueryable for LINQ to SQL will show you the query. var myquery = from x in dbcontext.MyTable where x.Prop1 == someValue select new { value1 = x.prop1, value2 = 5, }; var sqlstring = myquery.ToString(); //<= look in this string Opiate withdrawal during development: are NMDA receptors indispensable? Despite decades of research, the mechanisms that underlie opiate tolerance, dependence and withdrawal remain elusive. Evidence accumulated over the past ten years suggests that the NMDA receptor plays a central role in mediating the neuroplasticity induced by chronic opiate administration in adult animals. Yet, during ontogeny, the NMDA receptor complex undergoes qualitative developmental changes, which renders some of the basic assumptions for a role of the NMDA receptor in opiate withdrawal invalid in infants. Recent data indicate that NMDA receptor antagonists are not effective in blocking morphine tolerance, dependence and withdrawal in the neonatal rat. Roles for other glutamate receptor types (e.g. metabotropic glutamate receptors) have also been proposed recently. In this article, the latest evidence that characterizes the dynamic roles of glutamate receptors in these phenomena during ontogeny will be discussed.Hanger Hill Wood Hanger Hill Wood is a small remnant of ancient woodland to the east of the Hanger Hill Park and North Circular Road at Hanger Lane, in Ealing in the London Borough of Ealing. Named from 'Hangra', the Old English word for wooded slope. There is access from Hanger Lane (at pedestrian crossing by Hillcrest Road), alternative access is at several points on Chatsworth Road. Wildlife This site contains a variety of woodland native plants including Pedunculate oaks (Quercus robur), European beech (Fagus sylvatica), European yew (Taxus baccata), European holly (Ilex aquifolium), European ivy (Hedera helix) and other tree species. Breeding birds include common wood pigeons (Columba palumbus), common blackbirds (Turdus merula), Eurasian blue tits (Cyanistes caeruleus), common starlings (Sturnus vulgaris) and invasive rose-ringed

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www.kff.org/slideshow/public-opinion-on-single-payer- national-health-plans-and-expanding-access-to-medicare-coverage/) [2] [https://www.pewresearch.org/science/2019/11/25/u-s-public- vi...](https://www.pewresearch.org/science/2019/11/25/u-s-public-views-on- climate-and-energy/) ------ ycombonator Case in point. CNN segment mocking working class people. [https://twitter.com/DailyCaller/status/1221999373829144578](https://twitter.com/DailyCaller/status/1221999373829144578) ------ woodandsteel Conservatives are split about the changes the article discribes. Traditional conservatives are glad the labor movement was destroyed, and see the Knowledge Economy as good because it is the latest product of the unrestrained free market. On the other hand, Trump supporters are very angry, but the problem is that Trump's program won't do anything at all to fix the problems that are making them unhappy. ~~~ DebtDeflation > Trump supporters are very angry, but the problem is that Trump's program > won't do anything at all to fix the problems that are making them unhappy. There's no way around the fact that more education (doesn't necessarily mean college) and greater labor force mobility (providing people with the ability to move where the jobs are) has to be a significant part of the solution. Stating the facts is not condescension, but I guess it can and does cause politicians to lose elections. ------ realtalk_sp I read this and can't help but think that the real fools are the ones buying into the elitism narrative that the far-right has been peddling for years. It's a deliberate red herring exploiting the very human tendency to chafe at any perceived condescension. If people in the US primarily voted the issues (that matter and affect them) instead of on the basis of nonsense, Democrats would win by a landslide. Republican politicians are trading away relatively meaningless concessions (on things they likely don't genuinely care about like guns, LGBT rights, abortion, religion, etc) as a cover for tremendously detrimental policymaking that includes broad spectrum deregulation, huge transfers into the military- industrial complex, and massive cuts to social programs including education, healthcare, welfare, etc. We know that's the game plan. The real fools are the people who continue to fall for this shit. Edit: I should add that I don't necessarily believe everything about the Democratic Party's platform is valid. But they are unquestionably the better choice for the vast majority of voters. ~~~ Consultant32452 I don't understand this predilection for believing that other people can't have genuinely held beliefs and values that are vastly different from our own. I hope we can one day come to understand that it's complete lunacy for Mobile Alabama to force Los Angeles to live by its cultural values or vice versa. But today is apparently not that day. ~~~ realtalk_sp I never argued that the people themselves don't genuinely hold different beliefs about gun rights, abortion, religion, LGBT, etc. I meant two things: 1. in terms of their effect on peoples' lives, these issues pale in comparison to certain other ones AND 2. Republican politicians are using these highly emotionally-charged social issues to induce people to vote against their own interests on dimensions of governance that would meaningfully impact their quality of life. ~~~ Consultant32452 What makes you think you have any insight into what is in their best interest, which of their interests should be most important to them, or how they should measure their quality of life? ~~~ realtalk_sp If you don't have cost-effective access to good healthcare, you could literally die. And if you're poorly educated, you're much more likely to be less financially well off and that could itself lead to all kinds of suffering. But I get the sense that you're aiming for the presentation of being objectively insightful when really you're quite transparently arguing in bad faith for the sake of provocation, so I'll just leave it at that. ~~~ mixmastamyk The democrats didn’t deliver cost-effective healthcare or education or anything they keep trying to subsidize. Prices keep going up. Funny how that works. The smugness is just icing on the cake. ~~~ Consultant32452 I don't think these details about specific policy outcomes is where the battle is. Look at the way he's responding. This isn't about whether your ideas have better outcomes than my ideas. This is about ascribing you with bad motives, disingenuousness, or portraying you as a simpleton who can't understand political manipulation. This is about controlling you, putting you in the bad/stupid box so you can be dismissed and controlled. Their tactic is to call you stupid, liar, racist, sexist... You know the list. If you argue on their terms, if you start arguing you're not stupid for example, you're accepting their framing. This is a losing battle. Instead I find it's more effective to simply draw attention to their tactic. Once the tactic is revealed it loses efficacy. If I genuinely believe you to be stupid, evil, disingenuous, etc. I won't be able to genuinely hear you. You're just making noise. I would encourage you to try this experiment out some time. Instead of arguing specific policy, point out the tactic. It's repeatable and quite telling. ------ lngnmn1 Education (and inflated government) is a new way of signaling a higher social state, similar to scholastic priesthood of the past. It is entirely a social construct (aside from practical, concrete-math-based STEM and engineering). Another real-life aspect is that passing through a really decent schools like MIT or Caltech (or Yale, as an exception) is a proof (by example) that one is capable of self-discipline, concentration, self-improvement, able to do research and learn on by doing. Aside from that a degree is just and merely a social status certificate, a certificate of belonging to a higher social class (no matter actual skills and abilities). I myself am from a third-world social shithole and never went to a high school. I could, however, beat a vast majority of so-called liberal arts majors and even some Stanford grads, which I regularly did on this very site before CoCs and bans for use of an "inappropriate" language. So, there is nothing much to talk about. A crappy degree is a social status certificate, and obsession with language usage, long-words and polit- correctness and fancy abstract terminology is merely a signaling of assumed, self-proclaimed (and almost always absent) virtue. ------ Proven Lost me during the Warren donation paragraph. A learned person wouldn't support Warren so I am certain I've nothing of value to learn from the article. Up to the Warren paragraph I realized socialist-leaning parties suck more than illiberal democracy. No wonder globalists and socialists can no longer win in Europe. College degree is non-essential for most people, unnecessary for at least 50%. ------ whatsmyusername TBH I'm indifferent to the rural working classes plight. I'm LGBT and they've proven time and time again that they aren't my friends (both growing up in flyover country and later after I escaped that wasteland by how they vote and how they treat my brothers and sisters who didn't escape). If they want to vote against our shared interests and suffer the consequences, so be it. Me and mine will keep building without them and I won't spare a moments thought for their self inflicted suffering (except to be glad it isn't me). ~~~ WillDaSilva I completely understand your position, and sympathize with it, but it seems a bit shortsighted given that you have to live with these people, and things won't improve for your "brothers and sisters who didn't escape" if things don't get better for them. They'll happily drag you and yours down with them. This is all to say that we're all in this together, and while your indifference towards their plight may be justified, it is not productive. ~~~ anonsivalley652 In general: Give hate and antipathy no quarter. Where there is pain, it must our pain, or there will inevitably be revolution and chaos. Love without discrimination, even with those you disagree with, because they cannot be moved if we act like impetuous children by refusing to talk to them. Prejudice also cannot be convenient, or we likely possess internal inconsistencies we must face if we are to be

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BF1B25746C00786CE1" BuildableName = "微博@iOS程序犭袁.app" BlueprintName = "微博@iOS程序犭袁" ReferencedContainer = "container:微博@iOS程序犭袁.xcodeproj"> </BuildableReference> </BuildableProductRunnable> </ProfileAction> <AnalyzeAction buildConfiguration = "Debug"> </AnalyzeAction> <ArchiveAction buildConfiguration = "Release" revealArchiveInOrganizer = "YES"> </ArchiveAction> </Scheme> Strategic Impact This project will have impacts in the following six spheres: Development of tools and standards: The publication of the WHO guidelines Ensuring Balance in National Policies on Controlled Substances, guidance for accessibility and availability of controlled medicines in 10 languages, will provide an up-to-date and internationally agreed standard for policy and decision makers in Europe and other countries. This publication is an update of the older guidelines Achieving Balance in National Opioids Control Policy. The development and introduction of the International Opioid Consumption Database will allow national governments, international organisations and the general public to access country specific opioid consumption data, which will promote transparency, benchmarking, measuring, monitoring of and comparison between countries on the current status and future improvements in opioid availability in Europe. National policy-making processes and access to pain medication and substitution treatment: The outcome of the research undertaken in 12 European countries will result in country reports including concrete recommendations for legislative changes. These reports will be presented to relevant ministries, national organisations and health-care professionals in the 12 countries. This is expected to lead to the adoption of policies allowing for improved access to pain medication and national action in the area of substitution therapy. Better treatment of opioid dependence would contribute to decreased mortality rates, most importantly due to decreased HIV and hepatitis C infections, as well as addressing issues related to the prevention of opioid abuse. National capacity building: The six-countries workshops, national follow-up conferences in 12 countries and the review training for national and external lawyers will directly and indirectly build national capacities among civil servants and national lawyers in the area of policies for pain management, palliative care and opioid dependence. In total, 12 civil servants and three attorneys or lawyers will be trained in recognising barriers to opioid access and in analysing controlled drug legislations. Through national symposia and media communications, many more will be informed about the rational use of opioid analgesics and of treatment of heroin dependence with long-acting opioids. Research collaboration and sharing of experiences in Europe: This project will stimulate close collaboration, both among the wide range of health-related professionals in the Country Teams, and among the six Country Teams participating in each of the two workshops. The multi-country workshops will ensure that the applied research (situational analysis, policy and legislative reviews and recommendations) and country specific experiences are shared among participating countries. This project represents a first initiative to undertake research into opioid availability at European level and it is likely to stimulate the creation of a network that will last beyond the duration of the project. Contribution towards the implementation of European policies: The ATOME project has an impact on the implementation of policies. It is elaborated as part of the overall framework of the WHO Access to Controlled Medication Programme. Moreover, it supports the implementation of the goals of the Council of Europe which has established that palliative care is an inalienable element of a citizen's right to health care and that it is therefore a responsibility of the governments to guarantee that palliative care – including adequate pain treatment - is available to all who need it. The Council of Europe also states that the differences in the availability and quality of palliative care throughout Europe need to be addressed through increased co-operation between countries. Impact on the patients and populations themselves: The project is expected to have a positive impact for people in need of pain medication, people with opioid dependence and, related to the latter, populations at risk for attracting HIV and HCV infections. For a wide variety of conditions, patients do not achieve pain relief (analgesia in medical terms) without the use of controlled medicines: for example in cancer pain, HIV neuropathy, diabetic neuropathy, chronic pain, surgery pain (both around and after surgery), traumatic pain and sickle-cell disease. Opioid dependence increases mortality rates due to the poor quality and uncertain strength of heroin on the illicit markets and countries with a high prevalence of untreated illicit opioid use relate to high transmission rates of blood-borne diseases like HIV and HCV, even for the non-opioid dependent part of the population. The ATOME project promotes equal access to opioid medication to millions of patients affected by the above medical conditions in 12 European countries.Abraham Wright (deacon) Abraham Wright (23 December 1611 – 9 May 1690) was an English theological writer and deacon. Life Wright was sent to the Mercers' chapel school in Cheapside, and was afterwards from 1626 at Merchant Taylors' school. He was elected scholar of St John's College, Oxford, on 11 June 1629, and matriculated on 13 November. He was especially favoured by William Juxon for his good elocution. He was elected fellow of his college in 1632, graduated B.A. on 16 May 1633, and M.A. on 22 April 1637. When William Laud received Charles I in St. John's on 30 August 1636, Wright delivered the speech welcoming the king to the new library, and after dinner he acted in the play Love's Hospital, by George Wilde, before the king and queen. St. John's had long been famous for its plays. Wright is said himself to have written a comic interlude called The Reformation, acted at St. John's about 1631. Deaconry On 27 September 1637, Wright was ordained deacon by Francis White (1564?–1638), Bishop of Ely, in the chapel of Ely House. In the same year he published at Oxford a collection of sixteenth and seventeenth century epigrams, which he called ‘Delitiæ Delitiarum.’ On 22 Dec. 1639 he was ordained priest by Bancroft, bishop of Oxford, in Christ Church Cathedral. He soon became a popular preacher, and preached before the king, before the university, and at St. Paul's (Wood, Athenæ Oxon. iv. 275; cf. Hist. MSS. Comm. 2nd Rep. App. i. 79). In August 1645, he was presented to the vicarage of Oakham, Rutland, by Juxon, his constant patron, but he was not inducted, as he refused to take the covenant (cf. his poem to Juxon in Parnassus Biceps). He was expelled from his fellowship by the parliamentary commission (Wilson, Hist. of Merchant Taylors' School, ii. 728), and became tutor to the son of Sir James Grime or Graham at Peckham, and ‘read the common prayer on all Sundays and holy days, and on principal feasts he preached and administered. About 1655 he was prevailed with to leave Peckham and to live in London, where he was chosen by the parishioners of St. Olave in Silver Street to be their minister and to receive the profits of that little parish, of which he was in effect the rector, though formally to take actual possession of the living he would not (as his nearest relation hath told me), because he would avoid oaths and obligations’ (Wood, Athenæ Oxon.) He continued to minister there four years, according to the rites of the church of England, but was obliged to withdraw in 1659. On the Restoration, he was offered a chaplaincy to Elizabeth of Bohemia, but he declined it and took possession of his living of Oakham. He refused several preferments and lived quietly in the country, busy with his parish and his garden (cf. Hist. MSS. Comm. 2nd Rep. i. 396, 398). Personal Wright was the son of Richard Wright, silk-dyer, of London, was born in Black Swan Alley, Thames Street, 23 December 1611; apparently his father was the Richard Wright who was warden of the Merchant Taylors' Company, 1600–1, 1606–7, and master 1611–1612. He died on Friday, 9 May 1690, and was buried in Oakham church. He married, in 1643, Jane, daughter of James Stone of Yarnton, Oxfordshire. His son James (1643–1713) was a noted antiquary and man of letters. Works Wright's works have each some peculiar interest. Besides the ‘Delitiæ Delitiarum’ and some lines in ‘Flos Britannicus,’ Oxford, 1636, he was author of: Delitae Delitiarvm Sive Epigrammatvm Ex optimis quibusq[ue] hujus & novissimi seculi poetis in amplissima illa Bibliotheca Bodleiana ... in unam corollam conne

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and mounds of remains were found dumped on land registered to Hogwood Farm, where shocking conditions were exposed by the Sunday Mirror last month. Campaigners from animal charity VIVA discovered the graveyard near Brian Hobill’s farm. New pictures obtained last week clearly show the 12 skulls – some still with ear tags. VIVA founder Juliet Gellatley said: “We were appalled to find the pig graveyard in Hobill’s wood. Mounds of pig bones were piled high, covered in moss and undergrowth. (Image: Viva) (Image: Viva) “It’s a risk to human health. It also shows a blatant disrespect for these poor pigs who have endured a life of suffering and misery at the hands of the farmer. It’s so unnecessary. “Walking into woods strewn with bodily remains, I felt like I’d walked into the aftermath of a war zone. Unmarked graves for animals who were just a number. I found an ear tag ‘224’ next to the skull of a pig. “We found 12 skulls, jaws, shoulder bones and legs scattered around and a mound filled with rotting remains – like a macabre scene from a horror film. But these victims were alive and suffered and died for nothing.” The Sunday Mirror told last month how pigs crammed into a barn were found chomping on rotting carcasses. Sickening film taken by activists showed another dead hog with a huge wound being eaten by one of the 15,000 pigs packed into the farm. (Image: Viva) The skulls of two more pigs, a jaw bone and a leg that had been devoured in the same pen were a clear breach of DEFRA guidelines. Juliet went on: “Our initial investigation exposed widespread abuse in a disgustingly dirty ‘Red Tractor Approved’ factory farm. “Inside this hell hole we filmed cannibalism, sick dying pigs and wheelbarrows full of dead rotting animals. “Cannibalism is not natural behaviour for pigs and is caused by this bleak environment. “Now this shoddy graveyard shows a total disregard for animals. Government guidelines state the ‘burial or burning of fallen stock in the open is banned to prevent the risk of spreading disease from residues in the soil, groundwater or air pollution’.” (Image: Viva) VIVA campaigners were tipped off by a rambler who spotted the skeletons at the woodland in Warwickshire. Details have been passed to Trading Standards, Environmental Health and the Animal and Plant Health Agency. Juliet added: “Hogwood typifies institutionalised cruelty, sanctioned by government.” It is understood that Tesco officials inspected the farm in recent weeks. (Image: Viva) Tesco said: “We take animal welfare extremely seriously and expect producers to meet recognised standards as well as our own stringent, industry leading requirements. “Our dedicated agriculture team, Red Tractor and the Animal and Plant Health Agency visit farms regularly and any claims standards have not been reached are fully investigated.” Mr Hobill said: “The bones found in the woods are likely to pre-date the burial ban on fallen stock which was introduced in 2003. Before that time farmers were legally permitted to bury fallen stock.”The candle flame gutters. Its little pool of light trembles. Darkness gathers. The demons begin to stir. — Carl Sagan Before I struck out on my own, I was a member of Of Sound Mind, a newbie-oriented alliance primarily targeted at players with 15 million or fewer skill points. One of the alliance’s goals is to provide new players with a good cross-section of the game’s available activities, so we ran alliance fleet operations, small gang roams, solo training, collective industry and mining operations, and so on; any area a new player could hope to experience we had on offer, save one. Silence In The Deep Wormhole space has a well-deserved reputation as a lawless abyss inhabited by silent packs of deadly hunters. The lack of Local chat means an ambush can be prepared at any moment; a dozen enemy ships, often lethal strategic cruisers, can be cloaked and lying in wait. The wormhole-generation mechanic means virtually every entity lives “next door” at least part of the time, including groups you’d really rather not run into. Apart from the material hazards, visitors to Anoikis also have to contend with the Sleepers, a type of NPC unlike those seen anywhere in New Eden. Many sleeper ships field various forms of tackle and powerful, long-ranged energy neutralizers. Some sleeper ships also remote-repair each other, and all of them pack a powerful omni-typed punch. The Coin Of The Realm To match the unique difficulties, wormhole space offers unique rewards: the so-called “blue loot”, which can be sold to NPCs back in New Eden, and salvage, which is used by players to produce Tech 3 ships. Since Sleepers offer no bounties, all sleepers drop items of blue loot when killed, so that each sleeper ship has some payout. The most famous (and by far the most glamorous) form of wormhole PvE is the capital escalation. Sleepers, again unlike other NPCs, will warp in additional heavy battleships in response to a capital ship entering their site, and these battleships drop blue loot and can be salvaged just like all other sleeper ships. Used properly, this mechanic can allow dwellers in high-class wormholes to kill up to 40 extra Sleeper battleships per anomaly, worth a minimum of several hundred million extra ISK in blue loot alone. On The Cheap Profitable though it is, there’s a substantial barrier to entry for capital escalations — namely, having capital pilots and the courage to use them in the depths of wormhole space. In our quest for a group PvE activity we could do in wormhole space, eventually we managed to stumble onto a fleet composition and method that worked for us, but to explain it first I’ll have to set the stage. Home Sweet Home Some time ago, a newly-joining corp member revealed to us that he’d previously lived in J211915, known to those of us with short attention spans as “J*”. He also revealed that he still had an alt logged off inside J* in a covert ops ship with a probe launcher fitted. Eager to explore, we had him log on and locate the static high-security exit, then jumped a combat fleet in to take a look around. We were unsurprised to find that interlopers had moved into the wormhole. We inspected their towers carefully and decided that attacking them was beyond our capabilities, especially without support from capital ships, so we decided to try the stealthy approach and anchored a small starbase of our own. This tower, Endurance 1, would eventually withstand multiple assaults by the current inhabitants, eventually culminating in their losing an entire fleet of attack battlecruisers to a superb bombing run. This reverse was enough to make the other inhabitants sue for peace, and we formed a mutual defense pact. Conveniently, they were mostly Chinese, and we were mostly American, so we could cover each others’ timers nicely. Taking The Plunge J* actually has two static exits: one B274 exit to high-security space, and one Y683 exit to a class 4 wormhole. After we moved in and made peace with the other inhabitants, we quickly deduced that even two or three of us could trivially handle all the sites available in J* itself. Lured in by the promise of greater rewards, we formed a fleet of combat battlecruisers with shield logistics and jumped into our C4. The result was a disaster. We tried several times, each time grinding through the sites slowly, each time losing at least one ship to overwhelming damage and neuting power from the Sleepers. Determined, we furiously mutated our fleet composition, switching from shield to armor in search of a heavier tank and from combat battlecruisers to attack battlecruisers for greater range and projection. Eventually, we had the key insight that a pair of armor logistics ships could effectively transversal-tank much of the Sleepers’ damage, allowing us to run sites with only two logistics instead of three. Converging At Infinity As we iterated, we eventually derived what seemed to be an ideal fleet composition: A few heavily tanked armor Oracles, for heavy, long-range damage and tank alike; A pair of Augorors using the odd Of Sound Mind standard fit, providing enough repairing power to tank even the most dangerous waves of Sleepers; An armor cruiser (usually a Thorax or a Stabber) filling two roles: webbing and target-painting the primary, and cleaning up any frigates that managed to get too close to the Oracles; A Maller fitted with tractor beams and salvagers, to salvage sites as we went. Optionally a cheap battlecruiser fitted with armored warfare links and parked at a safespot to boost the repairing power of the Augorors. The Oracles form the heart of the fleet - they anchor on their target-caller and apply damage to the primary with their tachyon beams. The Augorors form a cap chain with

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and how enjoyable and delectable!" Quoth she, "And where is this compared with that I would relate to you on the coming night an the Sovran suffer me to survive?" Now when it was the next night and that was The Eight Hundred and Thirty-third Night, Dunyazad said to her, "Allah upon thee, O my sister, an thou be other than sleepy, finish for us thy tale that we may cut short the watching of this our latter night!" She replied, "With love and good will!" It hath reached me, O auspicious King, the director, the right-guiding, lord of the rede which is benefiting and of deeds fair-seeming and worthy celebrating, that the grass- widow came forward beside her stepson and raised her raiment from her behind until the half of her below the waist was stark naked; and she did even as her husband's son had done, and perked up her buttocks, leaning heavily upon her knees and elbows. Now when she acted on this wise the youth addressed her saying, "Thou canst not do it aright." "How so?" "Because the wind passing in through the postern passeth out through thy portal, thy solution of continuity." "Then how shall I do?" "Stopper thy slit wherethrough the air passeth." "How shall I stopper it?" "An thou stopper it not thy toil will be in vain." "Dost thou know how to stopper it?" "Indeed I do!" "Then rise up and stopper it." Hearing these words he arose, because indeed he greeded for her, and came up behind her as she rested upon her elbows and knees and hending in hand his prickle nailed it into her coynte and did manly devoir. And after having his will of her he said, "Thou hast now done thy best for me and thy belly is filled full of the warm breeze." On this wise he continued every day, enjoying the wife of his father for some time during his wayfare, till the traveller returned home, and on his entering the house the bride rose and greeted him and said, "Thou hast been absent overlong!"[FN#589] The man sat with her awhile and presently asked of her case for that he was fearful of his son; so she answered, "I am hale and hearty!" "Did my son ask thee of aught?" "Nay, he asked me not, nor did he ever address me: withal, O Man, he hath admirable and excellent expedients and indeed he is deeply versed in natural philosophy." "What expedients and what natural philosophy?" "He tucketh up his dress and exposeth his backside to the breeze which now passeth into his belly and benefiteth him throughout the cold season, and in winter he doeth exactly what he did in summer with effect as beneficial. And I also have done as he did." Now when the husband heard these her words he knew that the youth had practised upon her and had enjoyed his desire of her; so he asked her, "And what was it thou diddest?" She answered, "I did even as he did. However the breeze would not at first enter into my belly for whatever passed through the back postern passed out of the front portal, and the youth said to me, 'Stopper up thy solution of continuity.' I asked him, 'Dost thou know how to stopper it?' and he answered, 'Indeed I do!' Then he arose and blocked it with his prickle; and every day I continued to do likewise and he to stopper up the peccant part with the wherewithal he hath." All this was said to the husband who listened with his head bowed groundwards; but presently he raised it and cried, "There is no Majesty and there is no might save in Allah, the Glorious, the Great;" and suddenly as they were speaking on that subject the youth came in to them-- And Shahrazad was surprised by the dawn of day and fell silent and ceased to say her permitted say. Then quoth her sister Dunyazad, "How sweet is thy story, O sister mine, and how enjoyable and delectable!" Quoth she, "And where is this compared with that I would relate to you on the coming night an the King suffer me to survive?" Now when it was the next night and that was The Eight Hundred and Thirty-fourth Night, Dunyazad said to her, "Allah upon thee, O my sister, an thou be not sleeping, finish for us thy tale, that we may cut short the watching of this our latter night!" She replied, "With love and good will!" It hath reached me, O auspicious King, the director, the right-guiding, lord of the rede which is benefiting, and of deeds fair-seeming and worth celebrating, that the youth came in to his father and found his stepmother relating to him all they had done whilst he was away and the man said to him, "Wherefore, O youth, hast thou acted on such wise?" Said the son, "What harm have I done? I only dammed the waterway that the warm air might abide in her belly and comfort her in the cold season." So the father knew that his son had played this trick in order to have his will of her. Hereat he flew into a fury[FN#590] and forthright divorced her, giving her the contingent dowry; and she went her ways. Then the man said in his mind, "I shall never get the better of this boy until I marry two wives and ever keep them with each other, so that he may not cozen the twain." Now after a couple of weeks he espoused a fair woman fairer than his former and during the next month he wived with a second and cohabited with the two brides. Then quoth the youth in his mind, "My papa hath wedded two perfect beauties and here am I abiding in single blessedness. By Allah, there is no help but that I play a prank upon both of them!" Then he fell to seeking a contrivance but he could not hit upon aught for that whenever he entered the house he found his two step-mothers sitting together and thus he could not avail to address either. But his father never fared forth from home or returned to it without warning his wives and saying, "Have a care of yourselves against that son of mine. He is a whoremonger and he hath made my life distraught, for whenever I take to myself a wife he serveth some sleight upon her; then he laugheth at her and so manageth that I must divorce her." At such times the two wives would cry, "Walláhi, an he come near us and ask us of amorous mercy we will slap him with our slippers." Still the man would insist, saying, "Be ye on your guard against him," and they would reply, "We are ever on our guard." Now one day the women said to him, "O man, our wheat is finished," and said he, "Be ye watchful while I fare to the Bazar in our market- town which lieth hard by and fetch you the corn." So he left them and made for the town,--And Shahrazad perceived the dawn of day and fell silent and ceased saying her permitted say. Then quoth her sister Dunyazad, "How sweet and tasteful is thy tale, O sister mine, and how enjoyable and delectable!" Quoth she, "And where is this compared with that I would relate to you on the coming night an the Sovran suffer me to survive?" Now when it was the next night and that was The Eight Hundred and Thirty-fifth Night, Dunyazad said to her, "Allah upon thee, O my sister, an thou be other than sleepy, finish for us thy tale that we may cut short the watching of this our latter night!" She replied, "With love and good will!" It hath reached me, O auspicious King, the director, the right-guiding, lord of the rede which is benefiting and of deeds fair-seeming and worth celebrating, that when the father had gone forth and was making for the market-town, his son happened to meet him, and the two wives went up to the terrace wishing to see if their husband be gone or not. Now by the decree of the Decreer the man had in some carelessness forgotten his papooshes so he turned to the youth who was following him and said, "O my son, go back and bring me my shoes." The women still stood looking, and the youth returned in mighty haste and hurry till he stood under the terrace, when he looked up and said, "My father hath just now charged me with a charge saying, 'Do thou go sleep with my wives, the twain of them, and have each one of them

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observer in executive functions and ASD using the *ad hoc* observation instrument. ### Control of the Quality of the Data {#sec10} The quality of the observational data was controlled using two guidelines ([@ref5]): (a) Qualitative: consensual agreement was used in the first session to be coded for each participant (therefore, a total of eight sessions) by three expert observers in observational methodology, ASD and executive functions; (b) Quantitative: (b1) intra-observer reliability was calculated in three sessions for each child: one belonging to task 1, another to task 6 (both sessions randomly chosen) and the post intervention task session. We selected sessions of these three tasks because these tasks were the ones analyzed in this study, as will be explained later; (b2) inter-observer reliability was also calculated in three sessions for each child: one of task 1 and one of task 6 (randomly selected sessions but taking care that they were different from those used for the calculation of intra-observer reliability) and the post intervention task session. Cohen's kappa coefficient ([@ref21]) was calculated using software program GSEQ5, v.5.1. All results obtained are between 0.84 and 1.00, which according to the scale suggested by [@ref47] corresponds to a very good agreement. Therefore, the quality of the observational data obtained was excellent. Data Analysis {#sec11} ------------- ### Lag Sequential Analysis {#sec12} Lag sequential analysis was proposed by [@ref12], and subsequently extended by [@ref13], [@ref14], and [@ref65]. It is a highly effective data analysis technique for analyzing datasets compiled from observation that contain sequences of behaviors that are coded using an *ad hoc* observation instrument. It allows to detect those patterns of behavior, which occur with greater probability than would be predicted by chance. That is, starting with a behavior considered as a pattern generator (criterion or given behavior), and that tends to be chosen according to the objectives of each study, it looks for which other behaviors appear associated with the same with a probability greater than mere chance (conditional behaviors), both later (positive lag: +1, +2, etc.), and earlier (negative lag: −1, −2, etc.). In this way, prospective and retrospective patterns are obtained. In our investigation, these patterns allowed us to identify the sequential structure of the behaviors that the participants performed in interaction with the adult at the beginning and end of the intervention, as well as 1 month after the end of the intervention. The comparison of the patterns obtained in these three temporary moments allowed us to know their progress in the use of planning skills. This technique has been widely used in studies that analyze sports behavior, but its use in studies in the educational field is somewhat sparse ([@ref39]; [@ref73]; [@ref36]; [@ref31]). Especially, scarce are the studies with ASD students in which this data analysis technique has been used ([@ref18]; [@ref69]). We are unaware of works in which this data analysis technique has been used to evaluate planning skills in ASD children, a novel issue that is addressed in this work. In our study, the records of the participants were joined according to their SL (SL1 or SL2) and the task to which they corresponded. In each group of participants (SL1 and SL2), three tasks were analyzed: task 1 and task 6 (as they were the tasks that best allowed us to know the improvement of each group during the intervention when comparing the planning skills used at the beginning and at the end of the intervention) in addition to the post intervention task (this reflected the possible maintenance of the improvement after 1 month without intervention). To perform lag sequential analysis for each group and task: (1) the same criteria behaviors were chosen: those categories considered most relevant depending on the objective of the study given that they play a central role in planning skills and the resolution of daily activities. Specifically, the following categories---appearing alone or co-occurring with others---were chosen (categories indicated in bold in [Figure 1](#fig1){ref-type="fig"}): (1a) of those referring to participants: (i) all of criterion 4 *Execution*: *No response* (*NR*), *Unrelated behavior* (*Ds*), *Wrong use of strategy* (*UesEr*), *Change to a wrong strategy* (*CesEr*), *Correct use of strategy* (*UesC*) and *Change to a correct strategy* (*CesC*), as they indicated the accuracy of the response/answer that the participants issued during the execution of the activity as well as their flexibility to change the strategy; (ii) of criterion 5 *Control*, categories *Checking break* (*Ic*) and *Regulation* (*Rg*) given that they showed the existence of check behaviors of the participants on their own action and its quality; (iii) of criterion 6 *Error detection*, categories *No error detection* (*Nde*) and *Error self-detection* (*Ade*) as they showed the ability of the children to update their own activity during the performance of the task and therefore to detect or not the errors produced; (iv) all categories of criterion 7 *Evaluation*: *Non adjusted evaluation* (*Ena*) and *Adjusted evaluation* (*Eva*) because the evaluation informs about the children's ability to distinguish whether an objective has been achieved or not, and examine their execution/result comparatively with the demands of the task; (1b) of those categories referring to the adult, all ones of the observation instrument belonging to criterion 2 *Adult help for the child to carry out the activity: Error correction* (*Adc*), *Direct help* (*Adp*), *Indirect help* (*Ayi*), and *Motivating help* (*Aym*). They were chosen because they involved scaffolding strategies that provided support for the children in carrying out the tasks; (2) as given behaviors, all the categories that make up the observation instrument ([Figure 1](#fig1){ref-type="fig"}) were considered; (3) lag sequential analysis were performed prospectively (from +1 to +5 lags) and retrospectively (from −5 to −1 lags); (4) the level significance was set at *p* \< 0.05. Results {#sec13} ======= Of all the patterns obtained (61 retrospective and 45 prospective patterns in SL1 group, 34 retrospective and 35 prospective patterns in SL2 group), the most relevant for this study are described below. They are the most relevant because: (a) are generated by the children or (b) they are generated by the adult but contain infant's and adult's behaviors. Therefore, these patterns are those allow us to know the use of infant's planning skills. Consequently, the patterns generated by the adult that only contain adult's behaviors are not relevant and they are not described. Hence, the patterns generated by each group of participants in each task analyzed are presented, in addition to the patterns generated by the adult that included behaviors of the participants of each group in each task. Thus, [Figures 3](#fig3){ref-type="fig"}--[5](#fig5){ref-type="fig"} contain the patterns of SL1 group and the patterns of the adult in task 1, task 6, and in the post intervention task, respectively; [Figures 6](#fig6){ref-type="fig"}--[8](#fig8){ref-type="fig"} contain the patterns of SL2 group and the adult's ones in the same tasks. Within each figure, the patterns of the participants appear organized increasingly based on the suitability that the criterion behavior implies for the resolution of the task. Therefore, those patterns of the participants whose criterion behavior is less suitable are presented first and then those in which their criterion behavior is more appropriate. Adult patterns are presented starting with those whose criterion behavior implies more direct adult help to the participants and ending with those who assume less direct adult help. [Figures 9](#fig9){ref-type="fig"}--[11](#fig11){ref-type="fig"} show the comparison of patterns obtained in each task for each group. ![Prospective and retrospective patterns obtained in SL1 group. Task 1.](fpsyg-10-02824-g003){#fig3} ![Prospective and retrospective patterns obtained in SL 1 group. Task 6.](fpsyg-10-02824-g004){#fig4} ![Prospective and retrospective patterns obtained in SL 1 group. Post intervention task.](fpsyg-10-02824-g005){#fig5} ![Prospective and retrospective patterns obtained in SL2 group. Task 1.](fpsyg-10-02824-g006){#fig6} ![Prospective and retrospective patterns obtained in SL2 group. Task 6.](fpsyg-10-02824-g007){#fig7} ![Prospective and retrospective patterns obtained in SL2 group. Post intervention task.](fpsyg-10-02824-g008){#fig8} ![Comparison of the patterns obtained in each group in task 1.](fpsyg-10-02824-g009){#fig9} ![Comparison of the patterns obtained in each group in task 6.](fpsyg-10-02824-g010){#fig10} ![Comparison of the patterns obtained in each group in the post intervention task.](fpsyg-10-02824-g011){#fig11} To facilitate the jointly reading of the patterns described and its representation in the Figures we indicate at the beginning of each paragraph the code and name of the criterion behavior that generated the patterns described. [Figures 3](#fig3){ref-type="fig"}--[5](#fig5){ref-type="fig"}

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* Dropped Laravel <6 support * Dropped Symfony <4.4 support * Dropped PHP <7.2 support 1.1.0 ----- * Added Laravel 5.6, 5.7 and 5.8 support * Dropped Symfony 2.8 support * Dropped PHP 7.0 support 1.0.2 ----- * Added `Schema::connection()` to allow multiple connections 1.0.1 ----- * Added support for env variable usage in connection settings 1.0.0 ----- * Added Symfony 4.0 support * Added form type guesser * Added Var Dumper caster for Eloquent models * Added the `eloquent:make:seeder` command * Added the `eloquent:migrate:fresh` command * Added discovery of `App\Seed\DatabaseSeeder` when using Symfony Flex * Added Laravel 5.5 support 0.5.0 ----- * Fixed not creating the migrations directory on `eloquent:migrate:make` * Added Data collector * Added Laravel 5.4 support 0.4.0 ----- * Added `@internal` and `@final` PHPdoc annotations * Added model events integration * Deprecated `postgres` and `sql server` driver names in favor of `pgsql` and `sqlsrv`. The old names will be unsupported as of 1.0. 0.3.0 ----- * Added `wouterj_eloquent.migration_path` parameter to store the migration path * Added incompatibility for Laravel 5.3+ packages ([37aceab](https://github.com/wouterj/WouterJEloquentBundle/commit/37aceab0ede2af755b96c7d7356b8698a8efcca2) - theofidry) * Refactored booting of eloquent and facades to use `Bundle#boot()` ([669e9f4](https://github.com/wouterj/WouterJEloquentBundle/commit/669e9f4e05a6d6179e046c80af5e606878d413ce) - wouterj) * Required at least one connection ([7228be3](https://github.com/wouterj/WouterJEloquentBundle/commit/7228be36e1827bc75690c970a3390e1b32f69467) - wouterj) New Election Fraud Task Force November 3, 2014: Philadelphia District Attorney Seth Williams has created a new task force that will investigate and prosecute all allegations of criminal activity during elections. The new Election Fraud Task Force is part of the office’s Special Investigations Unit (SIU), and is comprised of ADAs and detectives who will be specially assigned to Election Day allegations. In the past the investigation and prosecution of Election Day crimes were assigned based on where and when the complaints came into the office. “This Task Force is another tool for my office to ensure that all crime in Philadelphia is investigated thoroughly, and prosecuted swiftly,” said District Attorney Seth Williams. “For far too long it has been assumed that Election Day in Philadelphia involves inappropriate actions at the polls. I want those assumptions to end now. The new Election Fraud Task Force helps guarantee that my office will not only thoroughly investigate Election Day complaints, we arrest and prosecute the culprits.” “No eligible Philadelphia voter should be impeded from casting a ballot,” said Ellen Mattleman Kaplan Interim President and CEO of the Committee of Seventy. “The Committee of Seventy applauds the District Attorney’s Office for taking aggressive and prompt action to investigate and, if appropriate, prosecute anyone who engages in elections-related criminal conduct.” “The District Attorney has shown a real commitment to making the integrity of elections a priority,” added City Commissioner Al Schmidt. “The creation of the Election Fraud Task Force will help Philadelphians be confident that elections in our city are conducted in a fair manner.” Today, the Election Fraud Task Force charged 64-year-old Oxana Turetsky of the 1200 block of Unruh Avenue with Tampering with Records, Criminal Mischief and Tampering with Voting Machines. Ms. Turetsky is scheduled to turn herself in to authorities later today. On May 20, 2014, police responded to a complaint at the polling location for the 53rd Ward, 13th Division of Philadelphia on the 6900 block of Summerdale Avenue. The Judge of Elections there notified police that Oxana Turetsky had written her name in ink on the voting machine at that location. Upon inspection, the officer confirmed that the name “Oxana Turetsky” was handwritten on the machine next to the box for “write in” candidates. Turetsky, a write-in candidate for committeeman, later admitted to writing her name on the voting machine. In February of this year, the Election Fraud Task Force charged 65-year-old Dianah Gregory with Fraud by Election Officers, Tampering with Records, Criminal Mischief, and Tampering with Voting Machines for her actions during the November 5, 2013 election. Dianah Gregory pleaded guilty to Tampering with a Voting Machine in an open plea on May 27, 2014. She was sentenced by the Honorable Michael Erdos to fifteen (15) months of probation. The investigation into Dianah Gregory began when the Philadelphia District Attorney’s Office received a complaint on Election Day at the Ethel Allen School polling site located at 31st & Lehigh Avenue. On location, a candidate for “Judge of Election,” William Thompson, explained that a voter left the polling site visibly upset after Dianah Gregory reportedly entered the voting booth and attempted to make a “write in” vote on the voter’s behalf. The voting booth was then examined as part of the investigation. The detective observed the name “Dianah Gregory” was written in marker on the voting booth. The name was scrawled next to the button to select a “write in” candidate. Still on location, Dianah Gregory admitted that she wrote her name on the voting machines, as she explained, for voters to know how to spell her name. Share this: Like this: LikeLoading... Related This entry was posted on November 3, 2014 at 5:48 am and is filed under Press Release. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.The author was not comparing the levels of violence, the author was comparing the levels of extremism. I think this paragraph says it pretty well. "So, just as Christianity and Islam have their extremist groups doing whatever they please in the name of “the greater good,” so does the hacker community. These people are nothing more than self-absorbed, self-righteous, immature, spoiled rotten, egotistical cyber-bullies. They’re terrorists of the internet... #5.1.2Frank Gifford's family reveals former NFL star suffered from CTE USA TODAY Sports | USA TODAY The late Frank Gifford, the former New York Giants star and 1956 NFL MVP, suffered from the degenerative brain disease Chronic Traumatic Encephalopathy at the time of his death in August, his family said in a statement Wednesday. Gifford's family had decided to have his brain studied following his death to study the link between football and brain injuries from repeated head trauma. "During the last years of his life Frank dedicated himself to understanding the recent revelations concerning the connection between repetitive head trauma and its associated cognitive and behavioral symptoms—which he experienced firsthand," Gifford's family said in the statement. "We miss him every day, now more than ever, but find comfort in knowing that by disclosing his condition we might contribute positively to the ongoing conversation that needs to be had; that he might be an inspiration for others suffering with this disease that needs to be addressed in the present; and that we might be a small part of the solution to an urgent problem concerning anyone involved with football, at any level. "The Gifford family will continue to support the National Football League and its recent on-field rule changes and procedures to make the game Frank loved so dearly—and the players he advocated so tirelessly for—as safe as possible." Gifford was inducted into the Pro Football Hall of Fame in 1977 in honor of his 12-year career with the Giants. He also spent 27 years as an announcer for Monday Night Football.Q: how to check QT_VERSION to include different header? Qt4 and Qt5 have different organization of header files. So I need to check the qt version to include different things, for example: #if QT_VERSION >= 0x050000 #include <QtMultimedia> #endif however, this seems does not work. The QT_VERSION has not been defined. How can I solve this problem? A: As soon as you include <QtGlobal> you can check that with macros: #if QT_VERSION < QT_VERSION_CHECK(5, 0, 0) It's the same as @Javier suggested, just a different, more readable to me, syntax A: As @Tay2510 commented, QT_VERSION is declared

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t appreciate it as much if I didn’t work so hard for it, if I didn’t undergo the challenges of working as a nurse (a career which I love btw). I can’t imagine travelling full-time; even my 2-3 trips a year alone were tough to plan and execute, let alone the money I have to save for it. At the end of the day I want to be in a place I call home, living a life I’ve worked hard for (because that also brings me a sense of joy) and one that makes me happy (and that means being near friends and family, taking up hobbies and such) – even if it’s “normal”. Whilst I agree that advertising is evil and travelling for the sake of bloating ones own ego (and letting everyone know about it) can be seen as equally as horrid, consuming other cultures and expanding ones own experience is a point worth considering. Travelling is not just a form of escapism, it can give one a less insular world view and see humanity as a whole for what it is, what it isn’t, what it could be and what it should be. Great point. It is great to travel to expose yourself to different cultures, and getting out of town every once in awhile is always recommended! Everyone needs this in their life at some point in my opinion, too. Still learning how to make such a life for myself! Most of my travel the past three years has been the result of work, teaching in China, and even during those long stretches of time abroad, I took advantage of every opportunity to “get away” from my responsibilities, by visiting different areas most people outside China had never seen. I can look back on those experiences and consider myself lucky to be there; but I also regard them as periods of struggle, confusion, and anxiety, which have all taught me important things about myself and how I lead my life. One other thing I’ve learned from my travels is that you can be a traveler of your own home. What I mean is, you can experience your hometown like a traveler, approaching this world you’ve grown up in (or spent a great deal of time in) with new eyes. I think one of things that is most lost on us in mainstream living is that sense of awe or appreciation you encounter when you really do see something new, even if it’s right outside your door. Take it upon yourself to see a side of that world you never imagined existed. LOVE this! I see so many new “van lifers” on youtube, and I can tell that some of them are definitely fake and basically showing lots of skin so that they can make some money off of subscribers clicking like, etc. Two years ago, I moved away from my family and have moved about 4 times since. Your comment about how you don’t have those other friends around anymore really hit the nail on the head with me about that. One of the things I miss most about the east coast is my friends. And yes, it was $$$$$ to move! Each time! Great blog and really thoughtful post! I often wonder when people say ‘lucky you’, if they really think about what that means… travelling is something I always wholeheartedly recommend, from the perspective of having the chance to see something more of the world, but it involves working hard beforehand for the money, as well as during the travel, working with your mindset… because the main piece of luggage which you’ll always take with you, no matter how minimally you have packed, is yourself. And sometimes, that can weigh in at quite a few kgs 😉 Also, whilst I like travelling slow and for a long period of time, it always gets to a point where I want to be working and settled somewhere, to let life grow and blossom more slowly over time, have regular meetings with regular friends, and contribute properly to something- building a life from which I don’t want to escape, indeed! But I think the travel can often give you the perspective to appreciate this latter golden nugget 🙂 That was a really elegant way to put it! ” the main piece of luggage which you’ll always take with you. . . , is yourself.” And it is good to become a tourist in your own city every now and then, but also to travel outside your comfort zone.Thanks for commenting! Love it. And you are exactly right in my view. Creating a life you don’t want to run away from is so important. That’s not to say that you shouldn’t want to travel. I do want to travel, and I have travelled. But I have to work to make it happen, and other commitments sometimes hold me back. Such is life, it is not just one big escape. That will catch up with you in the end I think. A really interesting post 🙂 Well said. To which I would add, “don’t pass through a city in a day, give each place time to work its magic on you”. I might travel halfway around the world to visit a country but I won’t whizz through it when I get there, I’ll just do two or three places in maybe two weeks. Enjoying your posts. Sound advice, don’t go travelling for travelling’s sake. I traveled around Europe in 1986 because I got accepted to the University of London and intended to spend a year in England studying, which I did. However that one year has now become 31 years. Wise words. So many discontented people when the answer is in their backyard. It’s why I’ve never drawn up a bucket list – it creates a sense of alienation from your life and loved ones and what happens if you can’t fulfil it? More discontent and a sense of failure. I’ve always followed “It seemed like a good idea at the time” and had lots of adventures including travel but not by design, more by happenstance. The ultimate travel – a loved person once whispered into my ears as I was at the airport, bidding farewell before a long trip “Enjoy the travel within, which is the best of all trips…” – is the trip within ourselves… I am 100% with you when you say “create a life you do not have to escape from”. Know what you are seeking to find when you think of escaping… and bring it into your life for good! Then you can have it everyday AND when you travel. How great would that be? Thank you for the post. Recently, the thought of “creating a life I don’t need to vacation from” came back to me. This post also serves as a reminder of the same. I have been sensing the minimalism call in my life. Again the post is a reminder. Great post. If we never had to work to earn our travel dollars, would we ever fully appreciate the travel? And if we are only travelling to put another notch on our travel belt or complete some bucket list, would we ever be satisfied enough to enjoy the destinations for what they are? As to being nomadic, I moved 28 times in the first 17 years of life and 6 times in the next 3. That knocked the nomadic right out of me. Since then, I have moved only 4 times in 44 years. Much as I love to travel, it is always nice to have a home base to come back toEven though one of Microsoft's goals with Windows 10 seemingly was to simplify its upgrade and deployment processes, the company introduced some new and very different ways with Windows 10 that Microsoft didn't do much to explain. Until now, that is. Over the past couple of days, Microsoft has quietly made available some new web resources providing some much-needed guidance on how product activation and updating work with its new operating system. Microsoft officials had shared a few tidbits in August with ZDNet's Ed Bott around how the company's activation policies had changed with Windows 10. But now there's an official and more fully documented web page that explains the various paths to activation that the company is now enabling with the operating system. (Thanks @WinObs, a k a Richard Hay, for tweeting a link to the new activation page.) In order to decipher the new "Activation in Windows 10" page, a couple of definitions first need to be understood."Activation" is the process via which Microsoft attempts to verify that a copy of Windows is "genuine." And "digital entitlement" is Microsoft's name for the new method of activation in Windows 10 that doesn't require users to enter a product key. more ed bott Troubleshooting and repairing Windows 10 problems The Anniversary Update to Windows 10, version 1607, has been rolling out for the past few weeks, and some early adopters are experiencing issues. Here's Ed Bott's guide to some specific fixes for known issues along with time-tested troubleshooting tools and techniques. Read More "Depending on how you got your copy of Windows 10, activation will use either a digital entitlement or a 25-character product key," Microsoft's new resource page states. The page then goes on to list a handful of different ways users potentially may have gotten Windows 10 -- ranging from upgrading for free from Windows 7 or 8.1, to buying a copy of the product from a retailer or on a new device -- and the required activation method. There are a number of subsections linked from the main page, including how to activate after reinstalling Windows 10; activating the latest Windows 10 Insider Preview; and activating Windows 10 after a hardware configuration change.after a config change. Microsoft also has a "Need Help With Windows 10" page that includes links on activation and a host of

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only is it huge (20×30), but it’s a split perspective of the same image, one from the sky, one from below the waters. On the left there is a boy and a girl sitting high above the water in a patch of flowers, watching sailboats below and fireworks in the distance. On the right side is the image from below the water, with sharks swimming towards a light, deep below the sailboats, next to scuba divers. It’s really a fantastic poster and I’m thankful to have got a copy. Point is, all the posters are beautiful! Wonderful job from all the artists! Thank you! Most Unexpected Part Of Tour The Rain Harpua The Tight Rotation of Songs The end of mkdevo 3 Set Show at Chicago Honorable Mention: Hollywood Harry Hood a.k.a. HollyHOOD Summer 2013 was a unique tour for Phish for a plethora of reasons. There were a lot of unexpected surprises, some good, some bad, but all having an effect on the tour in one way or another. The biggest may be what happened to @mkdevo and all of his videos. For all of 3.0, if there was a song you wanted to check out and watch, everyone knew look no further than mkdevo. If you missed a show, no problem, you could watch it practically through his videos. The videos were arguably Phish’s greatest marketing tool as they were free and they exposed Phish to a generation of fans who never knew of the band before 2009. It’s definitely been a different tour with little to none visual footage as there has been in years past. Another big surprise was the Harry Hood from Hollywood, otherwise known as HollyHood. The last show of a 4 night stand between San Fran->Los Angeles, Hollywood was characterized by no new songs and lots of great, but typical, Phish excellence. All of the sudden, out of nowhere in the second set though comes this beauty. This magnificent mother of god Harry Hood that is instantly an all-timer. The song that started it all off in Bangor and never let down throughout the tour peaked in full capacity that Monday night, and that was a huge unexpected gift. It’s been said a bunch already, but 2012 and 2013 were very different. The chase for 200 songs changed the dynamic of the tour in 2012 and therefore 2013 not only had a much tighter rotation, but it truly felt like a tighter rotation. It made for interesting sets. There was plenty of variety among each jam and development and improvement with each play. The juxtaposition between the two summer tours was evident and unexpected. But by far, the most unexpected part of the tour was the rain. Without the rain you don’t get the Chicago run – Friday’s cancellation, Saturday’s three set speciality, and Sunday’s Harpua. The rain was EASILY the biggest factor throughout the east coast, all the way through Chicago, with everyone jokingly calling it Phish Pours America and Phish Summer Pour 2013. Every night there seemed to be a storm or threats of storms, starting with SPAC having delays and thunderstorms. Jones Beach’s show was caught in the middle of the worst storm of the summer on Long Island, with the wind whipping people in the face and the rain pounding on all of us from above. The rain didn’t stop though, it just continued, down to Merriweather and Atlanta, before finally “peaking” in Chicago. When the show on Friday was cut short, the band was truly devastated, and rewarded us with three sets on Saturday. But when Sunday came and the first set was cut during Antelope, you could really tell how frustrated and annoyed the band was, especially Trey and Page. The rain was just a constant deterrent, but both the band and the fans NEVER let it get in the way. I’ll always remember this tour for the rain as will many, as the rain truly gave life to each and every show in a different, unique way. Show Of The Tour Holmdel, NJ – 07/10/2013 Columbia, MD – 07/14/2013 Chicago, IL – 07/21/2013 George, WA – 07/26/2013 George, WA – 07/27/2013 San Francisco, CA – 08/02/2013 San Francisco, CA – 08/04/2013 Honorable Mention: Saratoga, NY – 07/07/2013 The thing about this 2013 Summer Tour is that there really wasn’t a single bad show played. Seriously, you could throw any of these shows on and find numerous moments of full-band-connectivity. Even on their safest nights – 07/03 and 07/05 – even on the cancelled mess of 07/19, even when they came out with a song-based/energy affair on the second night of BGCA, each of these shows are still worth your time and your ears. Each display a Phish at the top of their game, attacking their shows no matter the style. And yet, for however strong as the tour is as a complete entity, their peak shows are simply based on an even higher level of musical connectivity, advanced experimentation, and evolutionary progression. From 07/10 and 07/14’s dedication to the band’s classics, representing an early peak for the tour, while displaying Phish’s desire to jam as a unified force, to 07/21’s show that – like the above jam segment – absolutely HAD to happen, to the string of shows at the Gorge on 07/26 and 07/27 that display the most consistent peak for the band in 2013, to the first and third night of SF that combined rarities and segues on 08/02, and a second set for the ages on 08/04, there’s just simply SO MUCH music we have to listen to from Phish moving forward. And, one cannot forget to mention the initial high-point of the tour – a show rightly praised when it happened, yet overshadowed now as the tour has unfolded – 07/07. We’ve truly been blessed throughout the entirety of this 2013 Summer Tour. The thought of the band continuing to build upon this at Dick’s and in the Fall is simply mind-boggling. Thankful is simply not enough. Top Run Saratoga Performing Arts Center, Saratoga Springs, New York: 3 Nights Merriweather Post Pavilion, Columbia, Maryland: 2 Nights The Gorge, George, Washington: 2 Nights Lake Tahoe, Stateline, Nevada: 2 Nights Bill Graham Civic Auditorium, San Francisco, California: 3 Nights Top run? How can one even decide…Between the magnificence and glory at Phish’s real life Gamehendge, Saratoga Springs, through the tri state area in New Jersey and Jones Beach, and the weekend run at Merriweather, almost every run was unique and special, loaded with stunning moments and overflowing with highlights. Lake Tahoe had great shows and the most special moment, Tweezer, and Bill Graham was the RIGHT way to end the tour, in the place where the birth of the counter culture happened. But one run stands above the rest — The Gorge. Like Phish’s last trip to the legendary venue, this weekend stand boasted complete shows filled with sick segues, exploratory jams and fantastic first and second sets. Night one at the Gorge had a AC/DC Bag, Timber, Wolfman’s Opener with a closing trio of McGrupp, Curtis Lowe and Melt. The first set was stunning as was the second set, which had an 18 minute Crosseyed and Painless, followed by Twist, Steam, Waves and a jam that has WAY TOO MUCH POTENTIAL, Twenty Years Later. Mango, Bug and Bowie!!! rounded the end, before a symbolic Rocky Top, signifying the awesome set, and then the moon howling Character Zero. The next night opened with a gorgeous Architect, the first Golgi of tour and then the first Curtain With of tour! After that came more great songs with Moma, Maze and the new debut, Say Something, a song I love. After Midnight ended the set with a tribute for J.J. Cale and kept the energy at an all-time high. The second set was even better! The famous Down with Disease->Undermind to start things off before another amazing highlight, Light->Sneaking Sally. A spacey and funky 2001 was nicely placed before a perfect ending trio – Walls of the Cave, Fluffhead and Run Like an Antelope. Talk about a two night stand. There are a few rules of Phish. Never miss a Sunday show. If you have the ability to go to a show, you go. Never miss Dick’s, and of course, Never miss The Gorge. For much of 2009 – 2012, no matter what musical leaps forward were made, Phish continually struggled with conceiving fully-flowing sets. While yes, there are exceptions – 08/07/2009 II, 06/27/2010 II, 10/16/2010 II, 05/28/2011 II, 07/03/2011 I, 08/15/2011 II, 08/19/2012 II, and 12/30/2012 II immediately come to mind – the start-to-finish thematic flow of a set – particularly a Set II – was one of the

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. 311. 312. 313. 314. 315. 316. 317. 318. 319. 320. FtsZ inhibition: a promising approach for antistaphylococcal therapy. Staphylococcus causes a large number of animal and human diseases and has been considered as a major health concern. With the emergence of resistant strains of staphylococcus, like methicillin-resistant Staphylococcus aureus and vancomycin-resistant Staphylococcus aureus, the search for novel antibacterial targets has intensified. FtsZ, a bacterial cytoskeleton protein, is involved in cell division. FtsZ assembles into protofilaments in a GTP-dependent manner, and forms a dynamic Z-ring at the mid-cell position. The assembly dynamics of FtsZ in the Z-ring are regulated by the combined actions of several FtsZ-associated proteins. Furthermore, the interaction of FtsZ with accessory proteins is essential for their recruitment to the Zring. A disruption of this interaction perturbs the Z-ring formation. FtsZ inhibitors like PC-190723 have been suggested to inhibit the Staphylococcus cell division by perturbing the assembly and stability of FtsZ polymers. In this review, we discuss the assembly dynamics of Z-ring and its role in cell division. In addition, we highlight recent advances suggesting the potential of FtsZ as a drug target for antistaphylococcal therapy.Ten teenagers have been arrested in relation to a series of armed robberies and aggravated burglaries across Melbourne and Geelong. During one of the armed robberies a 67-year-old woman was struck over the head with a metal pole several times, said Sergeant Cameron Scott of Victoria Police. "She received facial injuries and was taken to hospital." CCTV footage shows one of the alleged thieves at a St Albans milk bar. Credit:Channel Seven That armed robbery was one in a rapidfire series of alleged crimes in four hours from midnight on Tuesday through Melbourne's western and north-western suburbs. Eight teenagers have been charged after alleged aggravated burglaries, armed robberies and attempted armed robberies of milk bars in Derrimut, Newport, St Albans and Deer Park. The males charged are aged between 16 and 18. When arrested on Thursday morning the group were in two cars, one of which was allegedly stolen during one of the raids. CCTV footage from one of the milk bars allegedly shows the youths storm in with their faces obscured. They begin aggressively smashing the glass counters with weapons, including a hammer.Australian bookmaker opens Bitcoin wagering 5th February 2018 / lee There has been some new ground broken in online betting as a new online bookmaker in Australia, called Neds, launched the country’s first Bitcoin-based betting platform. The operator announced last week that they would launch their new betting platform, which has been developed in-house, and is opening with Bitcoin-only trading on the site. There are plans to add other cryptocurrencies this year if there is enough demand to warrant it. Neds explained that they are accepting deposits and are issuing payouts in Bitcoin, but without any options to convert. The odds on the Bitcoin version of the Neds site will be identical those at their regular, main betting site, just instead that the wagers will be traded in milli-Bitcoins (one-thousandth of a Bitcoin). Neds CEO Paul Cherry explained that the drive was there to create something amidst all the of the Bitcoin frenzy, and it afforded people who had bought Bitcoins but didn’t know what to do with them, a chance to use them in a new way. The operator is also offering to cover up to 2.5% of any transaction fees that are incurred by moving Bitcoins to the Ends site. Neds was created by former Ladbrokes Australia CEO Dean Shannon and they launched their operator in October 2017. Mentioned offers may be restricted to new customers, T&C's apply. Older offers may be not valid anymore. See details directly at the bookmaker's website. 18+. Please Gamble Responsibly. * All mentioned odds were valid at the time of writing. Betting odds are subject to fluctuations. Please check the current odds with the respective bookmaker!Fiction publishers complained that 2017 was a difficult year to get attention in a fast-moving media climate that was intensely political. But some of the year’s best novels spoke to current events, whether directly (as in Mohsin Hamid’s refugee story Exit West) or indirectly (George Saunders’s Lincoln in the Bardo is about the Civil War, but its comments on race feel relevant to the present). Other common themes emerge: new parenthood, a search for identity, an obsession with the past. Several of them feature ghosts. But two elements unite every title on the list: compelling writing and fresh storytelling. 10. New People, Danzy Senna Riverhead Books Senna’s latest racial satire focuses on a multiracial couple, Khalil and Maria, in which each half is grappling with complicated feelings about identity. With humor, understanding and a touch of sympathy, Senna’s novel is both knowing and biting. Buy it on Amazon 9. Days Without End, Sebastian Barry Viking In this riff on the American frontier genre, narrator Thomas McNulty and his sweetheart John Cole live through a series of trials: performing as women in a saloon, fighting in the Indian and Civil Wars, escaping random attacks in Postbellum South and avoiding being caught as gay lovers. Their story is both simple and strikingly choreographed. Read the TIME review Buy it on Amazon 8. The Ninth Hour, Alice McDermott Farrar, Straus and Giroux The Little Nursing Sisters of the Sick Poor meet Annie at her lowest point: she’s pregnant, and her husband has just committed suicide. With help from the nuns, Annie and her daughter are spared from destitution—but the intervention has ramifications that echo through generations. McDermott offers up a version of sisterhood that’s both historical and relevant. Read the TIME review Buy it on Amazon 7. The Changeling, Victor LaValle Spiegel & Grau The myth of the bad mom gets the horror-story treatment in this novel, which takes place deep in the boroughs of New York City. Apollo Kagwa and his wife Emma Valentine are thrilled to welcome their first child, but soon after his birth, Emma feels a strange distance from her son—is this the boy she birthed, or some sinister imposter? The story cleverly interrogates parenting norms, racial prejudice and technological quandaries. Read the TIME review Buy it on Amazon Exit West, Mohsin Hamid Riverhead Hamid tells the story of a couple whose love story begins just as war breaks out in their city, which is unnamed but resembles Lahore. The only path to safety is through a series of enchanted doors that lead them, and a surge of other refugees from around the world, to western cities where they face new threats from the residents who’d prefer these migrants went back to where they came from. Read the TIME review Buy it on Amazon 5. Lincoln in the Bardo, George Saunders Random House In his first full novel, Saunders has gained an even wider audience, winning the 2017 Man Booker Prize for this historical ghost story about Abraham Lincoln. The night after his young son is buried, as the Civil War rages, the President visits the cemetery for a final farewell, only to be observed by a ragtag cast of souls who can’t bring themselves to leave their earthly remains behind. Read TIME’s conversation with Saunders Buy it on Amazon 4. Manhattan Beach, Jennifer Egan Scribner The Pulitzer Prize winner’s new novel, seven years after A Visit From the Good Squad, marks a move away from the experimental—this is a straight historical novel, set mainly during World War II. The book’s heroine, Anna Kerrigan, is a character perfectly calibrated for Hollywood, with verve, vulnerability, and a tough-as-nails glamour that transitions from her job as the first female diver to work on war ships to her nights in gangster-filled night clubs. Read the TIME review Buy it on Amazon 3. Transit, Rachel Cusk Farrar, Straus and Giroux Cusk’s second novel in a planned trilogy goes minimal on plot, maximal on observation. The plot structure in the book is the renovation of the narrator’s London flat, and the spirit of transformation is mirrored in her conversations: With her contractors, her friends, her old flame. Through elegant meditations on contemporary life, Cusk’s depiction of her narrator is not so much portrait as a photo negative—mysterious, poetic and in contrast to her world. Read the TIME review Buy it on Amazon 2. White Tears, Hari Kunzru Knopf Publishing Group The British novelist skewers American culture in this treatise on whiteness and cultural appropriation. Two young white men breaking into the music industry find success when they record random noises in a New York City park and discover the voice of a man who wasn’t there. They pass the recording off as a rediscovered blues song—only to learn their lie may be accidentally based in reality. The hunt for the truth takes them on an unnerving journey through

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éens par milliers, l'historien observe un mouvement inverse d'Asiatiques vers l'Europe quasi insignifiant : le groupe le plus fourni est sans doute constitué des charpentiers indiens, quelques dizaines, qui viennent travailler aux chantiers navals lisboètes, et dont certains font souche localement. Pour des achats européens de marchandises qui s'élargissent des épices vers les tissus, les ventes de vin et de lainages en Asie méridionale demeurent symboliques, obligeant, pour solder les comptes, à d'importantes sorties d'espèces d'Europe ou d'Amérique ibérique. Dans la phase qui précède la colonisation, les contacts directs entre Europe et Asie méridionale restent si limités qu'ils favorisent la persistance de mythes des deux côtés : fantasmes sur la richesse et la cruauté asiatiques, d'un côté, caricatures des « gens à chapeaux » dans les poses parfois les plus ridicules, de l'autre, comme on le voit sur les miniatures ou les parois des temples en Inde. L'effet visible produit par les Européens sur les sociétés sud-asiatiques paraît au total assez infime : en dehors de la naissance de quelques villes coloniales, qui restent des enclaves, et constituent des cités assez modestes en comparaison des capitales autochtones, il se résume pour l'essentiel à l'introduction de plantes américaines dont l'une au moins, le piment, connaîtra un succès extraordinaire, et à quelques cas d'acculturation par conversion au catholicisme parmi les populations côtières (les seules conversions massives concernent les Philippines espagnoles). La connexion entre Europe et Asie demeura donc quantitativement limitée, et discontinue, dans l'espace comme dans le temps — ce jusque dans la période de la colonisation à grande échelle. Entre un Bengale soumis à deux siècles de domination britannique, et certaines îles extérieures de l'archipel indonésien qui connurent tout juste quarante années de règne hollandais, il n'y a pas de commune mesure. Certaines zones virent leur structure productive totalement remaniée par le développement d'une agriculture de plantation : c'est le cas des Moluques méridionales (clou de girofle, noix muscade), de l'Assam et du haut pays de Ceylan (thé), d'une partie de la Malaisie (caoutchouc, palmier à huile), de certaines îles des Philippines (canne à sucre), des hautes terres de Java-Ouest (café). Le développement des plantations s'accompagna de mouvements massifs de main-d'œuvre, de l'Inde centrale vers l'Assam, du Tamilnad vers Ceylan et la Malaisie, de Java vers l' _Oostkust_ de Sumatra, ou du Tonkin vers la Cochinchine. La colonisation signifiait là un bouleversement complet, de nature révolutionnaire. Mais dans de bien plus vastes zones, elle se traduisit par un simple remaniement de structures d'extraction fiscale déjà en place, dont le poids sur les paysanneries s'accrut dans des proportions variables, suivant les lieux et les époques. Ce fut le cas dans la plupart des régions de l'Inde. Si la commercialisation de l'agriculture progressa sans doute globalement, l'essentiel de la production agricole restait destiné à l'autoconsommation paysanne. On ajoutera que dans les zones de montagnes et de grandes forêts, certes peu peuplées, mais couvrant ensemble plusieurs millions de kilomètres carrés, l'ordre étatique de la colonisation ne parvint généralement guère mieux à s'imposer que, précédemment, celui des États antérieurs à cette nouvelle période qui s'ouvrait. Ces populations très diverses, pratiquant l'agriculture sur brûlis, restaient autonomes _de facto_ , recevant tout juste, de temps à autre, la visite d'un explorateur, d'un missionnaire ou d'un ethnographe. L'effet en retour de l'intrusion des Européens en Asie méridionale fut pour sa part moins mesuré qu'on ne le croit généralement. La découverte de sociétés policées n'ayant pas connu la révélation chrétienne contribua au bouleversement des idées qui caractérisa la Renaissance. Par ailleurs, les voyages aidèrent au développement de nouveaux savoirs linguistiques, cartographiques et botaniques en particulier. La compilation du _Hortus Malabaricus Indicus_, réalisée au Kerala à la demande d'un gouverneur hollandais, servit de matériau à Linné pour sa classification des plantes. Outre les épices, déjà familières des tables européennes au moins depuis le XIIe siècle, arrivèrent aussi en Europe les objets divers, aux formes parfois extravagantes, qui remplirent les cabinets de curiosités (comme la collection des Médicis à Florence), ainsi que les animaux « exotiques », comme les éléphants ou les rhinocéros, qui inspirèrent les artistes de la Renaissance, un Dürer ou un Raphaël. L'imaginaire européen fut grandement stimulé par ce contact avec l'Asie méridionale. Mais celle-ci était aussi une grande puissance économique, dont l'expansion dut beaucoup aux navires d'Occident. À partir de la fin du XVIIe siècle, affluèrent en Europe les « indiennes », ou « calicots » (de Calicut), les tissus de coton fabriqués en Inde, utilisés d'abord surtout pour l'ameublement et la décoration. Certains fabricants européens songèrent à mixer coton et lin pour produire des « futaines », faisant ainsi pénétrer les tissus de coton dans le domaine de l'habillement en Europe. À la fin du XVIIe siècle, un directeur de l'East India Company eut l'idée de faire fabriquer en Inde deux cent mille pièces de tissus pour le marché européen, introduisant ainsi le « prêt-à-porter » dans la mode vestimentaire. L'Asie méridionale, entrée d'abord dans les demeures des Européens, commença à parer leurs corps. Les conséquences à long terme pour les économies européenne et asiatique furent considérables. Tandis qu'au XVIIIe siècle la mode des indiennes se répandait à travers toute l'Europe, les fabricants européens, incapables de reproduire la qualité des produits indiens, du fait de la supériorité des Indiens en matière de teinture, tentèrent de se protéger de la concurrence par des mesures douanières. Mais, ne réussissant pas à exclure totalement les indiennes du marché, ils choisirent la voie de la substitution d'importations en développant l'innovation technologique, avec la _spinning Jenny_ , puis le métier d'Arkwright, qui leur permirent d'abaisser leurs coûts et de devenir enfin compétitifs. Ainsi peut-on estimer que l'afflux des textiles indiens en Europe fut largement à l'origine de la révolution industrielle. En outre, suivant l'hypothèse peut-être osée d'A. R. T. Kemasang, l'amélioration de l'état de santé et de la capacité de travail par temps froid liée depuis les premières décennies du XVIIIe siècle en Grande-Bretagne à la consommation massive de thé aurait permis un important accroissement de la productivité. Ceci va en tout cas à l'encontre des idées reçues sur l'avance de l'Europe. Écrire une histoire connectée devient à la fois plus simple et plus complexe lorsqu'on aborde la période de domination colonial

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We are really excited about the power and capability offered by the new experience and APIs available on the resource manager model for Virtual Machines. We think this is really going to change the way you can use the cloud in a lot of ways. With the release of the new model, you can deploy, manage and monitor related services in a resource group. Resource Manager enables deploying complex applications using templates, configures virtual machines using VM extensions, and incorporates access management and tagging. It also includes scalable, parallel deployment for virtual machines into availability sets. In addition, the new model provides lifecycle management of Compute, Network and Storage independently. And there’s a focus of enabling security by default with the enforcement of virtual machines in a Virtual Network. From a feature standpoint, almost all the features are supported for compute, network and storage under Azure Resource Manager with a few exceptions while we've added the ability to create scalable deployments using Virtual Machine Scale Sets. In addition, we are continuously improving the user experience and adding more features to the azure portal to bridge the experiences. Because of this new capability and growing deployment base in the Resource Manager model, we want to enable customers to be able to migrate existing deployments in Classic. Migration of IaaS resources from Classic to Resource Manager Stack The following articles take you through a step-by-step workflows of how to plan the migration and go through the entire process of moving your deployments into the resource manager model. PowerShell community scripts to clone Virtual Machines In addition to offering the platform service in public preview, we’re also releasing community-based PowerShell scripts that allow you to clone the virtual machines from the Classic to Resource Manager Stack. We are also accepting community contributions on the script repository. Next steps We will continually add more features and capabilities to the migration service in an effort to simplify your experience. In the meantime, hope to receive your feedback on the migration experience. Alternatively, you can also comment in our technical articles.Adolescent resilience: an evolutionary concept analysis. Resilience is a concept that has enormous utility in nursing, although there is a need for concept clarity as it relates to adolescence. The purpose of this article is to describe the concept and apply the Evolutionary Model of Concept Analysis to resilience in adolescents. A literature search and an analysis of 22 articles specific to the adolescent population were completed. The literature review revealed adolescent resilience to be a composite of attributes that include the characteristics of the adolescent, sources of social support, and available resources. Implications for nursing and a proposed model of adolescent resilience are presented.Jamie_Harris “Both WASR and UF spent a significant amount of time on academic outreach in 2018” I hadn’t realised this; I thought that Animal Ethics focused more on this, while WASR focused more directly on foundational research. Do you think there will be overloaded between WAI and Animal Ethics or do the organisations have different approaches? Yes, I had thought about this. There was a question in the survey intending to check if people thought this was the case so far, and I didn’t see much evidence for it. But Id guess that those sorts of effects might be less obviously noticeable, or might take longer to become noticeable. “For example, the difference between assigning a 5% probability and a 50% probability is epistemically vast but arguably practically insignificant. It merely affects the amount of expected value represented by invertebrates by one order of magnitude. There are very roughly 10^18 insects in the world, and this number is still multiple orders of magnitude higher than the number of vertebrate animals.” Given this point, and the implications of Jacy’s comment, perhaps it would be preferable to conceptualise the impact of this research/career plan in this area as a form of advocacy, rather than as a form of enhancing our knowledge and affecting cause prioritisation? In some ways, your rough career trajectory might look similar, but it might affect some decisions e.g. how to split your time between focusing on further research and focusing on giving talks to EA groups, academic settings etc. This list has research questions across a number of different themes or categories, e.g. “wider understanding of current animal use” and “evaluations of farmed animal interventions.” To think about which questions are important, I’d suggest categorising the questions, then prioritising the overall categories. Sentience Institute has summarised foundational questions in effective animal advocacy, and we tend to prioritise research that we think will best help to improve our understanding of these questions (see our research agenda). Frankly, there are huge amounts of research questions that could be useful in some shape or form to effective animal advocacy. I’m not aware of anyone having compiled a comprehensive list, although I think that this might be worthwhile doing at some point, especially to coordinate the different organisations and individuals conducting research and to avoid unnecessary duplication of effort. There are also important considerations about the risk that rainforest preservation efforts might indirectly increase suffering. Many in the effective altruism community believe that a large proportion of wild animals, especially invertebrates and other r-selected species, have net negative lives. Recently, this was the conclusion of a recent report by charity entrepreneurship. If you believe that there is a non-trivial chance that these animals can suffer or have morally relevant experiences, then the short- and medium-term effect of rainforest protection might be a counterfactual increase in wild animal suffering (see here for Brian Tomasik’s discussion of a related question). More widely, encouraging concern for habitat protection might encourage people to value non-sentient entities even where the interests of these non-sentient entities conflict with the direct interests of individual animals. In general, this seems to be a step in the wrong direction if you agree that moral circle expansion is desirable. This might encourage the likelihood of future dystopian scenarios which involve astronomical levels of suffering. In a sense, by promoting environmentalism via conservation, you might be reducing the chance of a global catastrophe via climat change but in

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. Choosing the most effective antibody therapy to combine with first-line chemotherapy remains an important consideration, but the data informing this choice is conflicting. Traditional meta-analyses are helpful in providing a direct comparison between trials with the same intervention and comparator. However, in settings when few or no direct comparisons of treatments exist, an indirect comparison approach \[[@pone.0140187.ref022]\] allows for the comparison of treatments between groups from different trials, if the studies have a common treatment parameter \[[@pone.0140187.ref023],[@pone.0140187.ref024]\]. The use of a network meta-analysis (NMA) by combining direct evidence with indirect evidence can often increase the precision of the comparison \[[@pone.0140187.ref025]\]. NMAs have been recently conducted in a number of oncology settings including metastatic breast cancer \[[@pone.0140187.ref026]\], metastatic pancreatic cancer \[[@pone.0140187.ref027]\], adjuvant treatment for pancreatic cancer \[[@pone.0140187.ref028]\] and Hodgkins lymphoma \[[@pone.0140187.ref029]\] to simultaneously examine the relative efficacy of multiple treatments by synthesizing both direct and indirect evidence. In this study, we carried out a systematic review of all randomized controlled trials (RCTs) that compared systemic chemotherapy regimens with and without bevacizumab, cetuximab or panitumumab for the first-line treatment of mCRC and conducted both direct meta-analysis, and indirect and combined NMAs to assess the impact of these agents on PFS and OS. Methods {#sec006} ======= Search strategy and selection criteria {#sec007} -------------------------------------- We performed a systematic review to identify studies which examined the survival outcomes of mCRC patients. Under consideration for inclusion were all RCTs which compared chemotherapy treatment alone to either i) chemotherapy treatment in combination with BEV or ii) chemotherapy in combination with EGFRis. RCTs that directly compared chemotherapy treatment with EGFRis against chemotherapy combined with BEV were also considered. Studies were included regardless of the chemotherapy backbone as long as the backbone was identical in both the treatment and control arms. Studies were included only if the patients were being treated with first-line therapy for the treatment of mCRC. Those studies with more than two treatment arms were included if one of more of the arms included an eligible comparison; only arms addressing eligible comparisons were included in the analysis. For EGFRis trials, only data from *K-RAS* participants with wild-type *K-RAS* Exon 2 tumors was included. We excluded non-randomized trials, as well as trials involving non-metastatic colorectal cancer patients. Trials that included radiotherapy, hormonal therapy, gene therapy or other immunologic therapy in one of the arms were excluded. Studies with a comparison of chemotherapy and a *VEGFi* or an EGFRi against no treatment (best supportive care), or against a *VEGFi* or EGFRi alone were excluded. When several reports discussed the same trial, the report with the most recent data was included. We searched Medline, Embase, and the Central Registry of Controlled Trials of the Cochrane Library. All databases were updated through to the second week of September, 2014. We did not place any language restrictions on the search. The complete search strategy employed has been provided ([S1 Text](#pone.0140187.s009){ref-type="supplementary-material"}). Our review has been reported using the PRISMA reporting guidelines ([S1 PRISMA Checklist](#pone.0140187.s008){ref-type="supplementary-material"}). Data extraction {#sec008} --------------- Data was extracted by two independent reviewers with discrepancies between the reviewers discussed prior to selecting trials for inclusion in the systematic review and prior to inclusion in the meta-analysis. Unresolved discrepencies were reviewed by a third reviewer. We recorded primary author, trial ID, treatment comparison, primary and secondary outcomes studied, location of the trial, recruitment period, number of patients randomized and evaluated in each treatment arm, age, gender, and K-RAS status. The studies were organized into three treatment groups; chemotherapy with BEV against chemotherapy alone, chemotherapy with an EGFRi against chemotherapy alone, and chemotherapy with BEV against chemotherapy with an EGFRi. For our analysis, studies examining cetuximab or panitumumab were grouped together as EGFRi. Studies with different chemotherapy backbones, methods of chemotherapy administration, or methods of antibody therapy administration were grouped according to the type of antibody therapy used. In trials involving a comparison with an EGFRi, only data pertaining to wild-type *K-RAS* Exon 2 patients was extracted. For each trial, we recorded PFS and/or OS of the treatment and control arms, the hazard ratio (HR), log-rank p-value, and confidence intervals when available. In studies where the HR, p-value, or confidence intervals were not provided, it was calculated from the log-rank p value, the number of events in each arm and the number of randomized patients in each arm using the Parmar method \[[@pone.0140187.ref030]\]. Statistical analysis {#sec009} -------------------- Pairwise meta-analyses were conducted to examine treatment regimens that were directly compared in the studies; chemotherapy vs chemotherapy with EGFRis, chemotherapy vs chemotherapy with BEV, and EGFRis vs BEV with chemotherapy in both arms. The results were combined into forest plots using Review Manager, version 5.2, using the random-effects model. To assess the comparability of included studies, between-study heterogeneity was estimated and reported using the I^2^ statistic; the value of I^2^ lies between 0% and 100%, where 0% indicates no observed heterogeneity and larger values show increasing heterogeneity \[[@pone.0140187.ref031]\]. We conducted a Bayesian NMA to examine the indirect comparison of EGFRis vs. BEV through the intermediate treatment of chemotherapy alone, and to combine the indirect comparison with the direct comparison, using WinBUGS, version 1.4.3. A detailed explanation of the statistical method \[[@pone.0140187.ref032]\] employed for the NMA has been provided ([S2 Text](#pone.0140187.s010){ref-type="supplementary-material"}). Bayesian NMAs were performed at three time points, which included: i) trials published prior to the FIRE-3 trial, \[[@pone.0140187.ref019]\] ii) trials up to and including FIRE-3, and iii) all trials published up to and including the CALGB 80405 trial \[[@pone.0140187.ref020]\], which was the last trial found by the literature search. In addition, a Bayesian NMA was conducted for all trials excluding FIRE-3. Sensitivity analyses were conducted to explore the effect of adjusting for the types of chemotherapy backbone (oxaliplatin-based, irinotecan-based or fluoropyrimidines alone) and the mode of fluoropyrimidines delivery (bolus or infusional). This was performed by including those effects as covariates in the meta-regression of the Bayesian NMA. The results were presented according to the guidelines of the Quality of Reporting of Meta-analyses (QUOROM) and International Society for Pharmacoeconomics and Outcomes Research (ISPOR) \[[@pone.0140187.ref033],[@pone.0140187.ref034]\]. Results {#sec010} ======= Literature Search Results {#sec011} ------------------------- Our electronic search of Medline, Embase and the Cochrane Central Register of Controlled Trials databases yielded 2435 potentially relevant articles. Our manual search through the 2013 and 2014 ASCO General Meeting abstracts produced an additional 62 results. Following a deletion of duplicate results from different databases, there were 1581 records. Ultimately, we identified 17 unique studies for inclusion in the meta-analysis, including 2 ASCO abstracts ([Fig 1](#pone.0140187.g001){ref-type="fig"}). [Fig 2](#pone.0140187.g002){ref-type="fig"} shows the network of available treatment comparisons, along with the number of times each comparison was made in a study. ![PRISMA flow diagram of included and excluded trials identified from the literature search.](pone.0140187.g001){#pone.0140187.g001} ![Network of treatment comparisons.\ The numbers represent the number of studies providing the comparison between the treatment regimens. The solid and dashed lines represent direct and indirect treatment comparisons of studies included in our analysis, respectively.](pone.0140187.g002){#pone.0140187.g002} Study Quality {#sec012} ------------- The quality of studies included in the NMA was evaluated using the Cochrane risk of bias tool \[[@pone.0140187.ref035]\]. A list of biases was summarized ([S1](#pone.0140187.s001){ref-type="supplementary-material"} and [S2](#pone.0140187.s002){ref-type="supplementary-material"} Figs). Publication bias was evaluated by constructing funnel plots for the studies included in each direct comparison for OS ([S3 Fig](#pone.0140187.s003){ref-type="supplementary-material"}). The three plots for OS were all symmetrical and show no evidence of publication bias. All included studies were randomized and followed intention-to-treat analysis for the primary endpoints (PFS and OS). Two of the studies (CALGB 80405, ITACA) were published only in abstract form, and we were unable to judge whether selection, allocation, assessment, attrition and/or reporting bias were present. All of the trials reported median PFS, and all except for one (Kabbinavar et al, 2003), provided extractable data for OS

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575, 1449, 283, 2537, 17605, 313, 1229, 15, 24, 10, 3677, 313, 1423, 15, 1237, 10, 28899, 313, 1619, 15, 1762, 10, 575, 1235, 283, 3046, 28899, 313, 3156, 10, 12347, 313, 1610, 15, 4196, 10, 23850, 313, 1839, 15, 25, 10, 575, 1549, 283, 2090, 16198, 313, 1423, 15, 24, 10, 2222, 313, 1717, 15, 2597, 10, 21451, 313, 1099, 10, 575, 1967, 283, 1976, 1839, 313, 22, 15, 22, 10, 2031, 313, 1012, 15, 25, 10, 3507, 313, 25, 15, 1036, 10, 575, 12515, 2363, 3011, 15, 25, 14808, 3069, 14808, 26, 15, 46027, 15, 21, 14808, 3069, 14808, 25, 15, 25320, 15, 22, 14808, 3069, 14808, 26, 40702, 40702, 30456, 3473, 575, 17151, 8292, 2452, 32960, 313, 3680, 15, 18, 10, 20210, 313, 3655, 15, 23, 10, 35216, 313, 2526, 10, 575, 52, 9207, 3422, 2614, 3473, 14380, 15, 23, 14808, 3069, 14808, 1012, 15, 25, 15220, 15, 21, 14808, 3069, 14808, 1012, 15, 25, 15468, 15, 21, 575, 12558, 28013, 2614, 3473, 3547, 15, 17, 14808, 3069, 14808, 26, 15, 49310, 15, 25, 14808, 3069, 14808, 26, 15, 31408, 15, 19, 575, 15163, 2280, 3605, 1610, 15, 17, 14808, 3069, 14808, 24, 15, 18348, 15, 26, 14808, 3069, 14808, 23, 15, 49268, 15, 520, 40702, 40702, 42902, 301, 6222, 313, 7913, 16, 21087, 10, 575, 12481, 13559, 11395, 15, 22, 14808, 3069, 14808, 1449, 15, 520, 2691, 15, 17, 14808, 3069, 14808, 1671, 15, 520, 2759, 15, 19, 575, 44139, 13559, 1867, 15, 25, 14808, 3069, 14808, 25, 15, 40948, 15, 24, 14808, 3069, 14808, 25, 15, 24, 3079, 15, 25, 575, 44004, 13559, 7749, 15, 22, 14808, 3069, 14808, 1706, 15, 24, 14322, 15, 20, 14808, 3069, 14808, 2405, 15, 3156, 805, 15, 20, 575, 16854, 13559, 2082, 15, 26, 14808, 3069, 14808, 2405, 15, 26422, 15, 24, 14808, 3069, 14808, 1731, 15, 36630, 10605, 10470, 746, 313, 19, 15, 25, 10, 3583, 313, 1036, 15, 21, 10, 3677, 313, 24, 15, 3071, 10, 12558, 24298, 27000, 22341, 313, 2082, 15, 22, 10, 17306, 313, 1706, 15, 22, 10, 36043, 313, 2950, 15, 18, 10, 1785, 32177, 3270, 41537, 3134, 1971, 35630, 313, 3677, 15, 25, 10, 18121, 313, 1619, 15, 19, 10, 22, 2787, 313, 3011, 15, 24, 10, 1785, 32177, 1098, 249, 28333, 313, 2251, 10, 14009, 313, 2082, 15, 24, 10, 19807, 313, 2526, 15, 22, 10, 3378, 13440, 2728, 19105, 313, 1731, 15, 24, 10, 14840, 313, 2417, 10, 24454, 313, 1671, 15, 24, 10, 5180, 18, 48167, 19, 62, 187, 187, 20, 15, 19, 15, 23736, 273, 253, 767, 9600, 1712, 84, 31253, 94, 187, 35000, 187, 187, 23648, 273, 26281, 281, 1098, 249, 4918, 1754, 327, 253, 767, 9600, 310, 2011, 275, 544, 3235, 374, 1084, 85, 17553, 910, 709, 14, 881, 568, 2420, 7129, 10635, 327, 253, 14809, 6490, 29609, 13, 627, 497, 15470, 5086, 313, 3079, 15, 24, 2673, 285, 29226, 5343, 1363, 313, 1449, 15, 23, 2673, 13410, 281, 4763, 1098, 249, 4918, 15, 380, 2264, 1180, 323, 5207, 1971, 369, 8521, 310, 38627, 313, 3156, 15, 23, 10970, 3235, 374, 40189, 12645, 1754, 327, 20413, 16, 34, 10114, 9600, 347, 2429, 281, 14809, 6490, 9600, 2796, 47, 11, 14808, 30, 14808, 38723, 481, 40189, 9050, 15804, 16, 34, 10114, 61, 187, 11, 47, 11, 11767, 25606, 6490, 61, 187, 11, 47, 11, 11767, 11, 81, 11, 60, 66, 1084, 12749, 4174, 18, 910, 709, 14, 881, 568, 2420, 14, 4174, 986, 40953, 1397, 4313, 323, 1971, 8521, 313, 39943, 7726, 10, 12481, 1180, 323, 5207, 1971, 310, 8521, 34384, 313, 2597, 15, 22, 10, 35833, 313, 3156, 15, 23, 48744, 17, 15, 5831, 26, 15, 25, 313, 24, 15, 25, 283, 805, 15, 20, 10, 40702, 40702, 39, 358, 2339, 2796, 47, 11, 14808, 30, 14808, 29868, 48744, 17, 15, 5831, 23, 15, 24, 313, 22, 15, 19, 283, 25, 15, 23, 10, 40189, 8521, 43995, 313, 3507, 15, 18, 10, 23163, 313, 1449, 15, 23, 10, 575, 12412, 7133, 8320, 313, 3680, 15, 19, 10, 1322, 575, 4120, 5034, 7133, 18467, 313, 1508, 15, 26, 10, 35649, 9048, 417, 8521, 10683, 313, 1166, 15, 26, 10, 22488, 313, 3046, 15, 20, 10, 40702, 40702, 46, 2339, 2796, 47, 11, 14808, 30, 14808, 28560, 48744, 17, 15, 5831, 13743, 15, 19, 313, 2945, 15, 22, 283, 34230, 15, 23, 10, 40189, 8521, 23580, 313, 1525, 15, 18, 10, 15270, 313, 3079, 15, 24, 10, 575, 12412, 7133, 19044, 313, 2222, 15, 17, 10, 1322, 575, 4120, 5034, 7133, 1012, 313, 21, 15, 18, 10, 35649, 9048, 417, 8521, 20, 313, 17, 15, 26, 10, 17864, 313, 3208, 15, 20, 10, 5180, 20, 48167, 21, 62, 187, 187, 15545, 327, 253, 20413, 16, 34, 10114, 29609, 13, 1971, 369, 8521, 275, 29117, 10798, 313, 1525, 15, 18, 2673, 285, 45421, 10753, 313, 3507, 15, 18, 10970, 16257, 13, 247, 1029, 14, 38172, 1098, 249, 369, 8521, 275, 29044, 5086, 313, 2222, 2673, 285, 9166, 5343, 1363, 313, 3680, 15, 19, 10970, 17012, 369, 417, 8521, 275, 760, 1264, 5086, 1363, 313, 17, 15, 26, 2673, 285, 15567, 10753, 313, 1166, 15, 26, 2673, 2470, 3235, 374, 1084, 85, 17553, 910, 709, 14, 881, 568, 2420, 2536, 380, 2264, 1180, 273, 4292, 323, 5207, 1971, 369, 8521, 310, 854, 2787, 313, 2597, 15, 22, 481, 187, 187, 11888, 253, 20413, 16, 34, 10114, 29609, 13, 40137, 3081, 1363, 313, 1857, 15, 26, 2673, 651, 320, 13410, 323, 1098, 249, 4918, 15, 380, 2264, 1180, 273, 1363, 13410, 323, 1098, 249, 4918, 310, 374, 15, 18, 2069, 313, 34384, 16, 35833, 10, 326, 275, 253, 1711, 29609, 15, 380, 3064, 875, 253, 767, 9600, 369, 10126, 1534, 2470, 3235, 374, 1084, 85, 17553, 910, 709, 14, 881, 568, 2420, 2536, 380, 13653, 273, 46705, 247, 1098, 249, 1754, 327, 253, 20413, 16, 34, 10114, 310, 1199, 2169, 313, 36344, 884, 2069, 10, 2429, 281, 253, 14809, 6490, 29609, 2470, 3235, 374, 1084, 85, 17553, 910, 709, 14, 881, 568, 2420, 2536, 187, 187, 20, 15, 20, 15, 2006, 11724, 273, 14975, 281, 253, 3332, 20413, 16, 34, 10114, 1971, 29609, 1712, 84, 35173, 94, 187, 43067, 187, 187, 9083, 6876, 15588, 1098, 968, 275, 760, 47633, 313, 3121, 2673, 273, 253, 854, 2787, 13410, 1363, 15, 7214, 10677, 313, 740, 15, 22, 2673, 273, 253, 42444, 13410, 1363, 497, 15588, 1029, 14, 38172, 1098, 249, 15, 187, 187, 20, 15, 21, 15, 9052, 1761, 17888, 273, 1543, 281, 253, 16158, 3072, 1712, 84, 41545, 94, 187, 6154, 7040, 187, 187, 7992, 1761, 311, 839, 253, 1263, 1543, 281, 608, 15, 1036, 3041, 16158, 7747, 10652, 3387, 283, 1976, 14808, 10526, 13, 271, 5998, 374, 15, 16607, 3041, 7747, 313, 3156, 15, 23, 6, 273, 1110, 10652, 3387, 283, 1976, 14808, 10526, 13, 285, 884, 15, 20, 6, 273, 253, 1384, 15, 25, 3041, 16158, 3072, 275, 4104, 10, 651, 320, 13410, 281, 4763, 1098, 249, 4918, 13, 2556, 281, 253, 6752, 14809, 6490, 29609, 15, 496, 4499, 13, 253, 5998, 1180, 273, 1098, 249, 4212, 651, 320, 11848, 281, 577, 15, 40666, 3041, 313, 2597, 15, 22, 6, 273, 1110, 3387, 283, 1976, 14808, 10526, 273, 2363, 13, 285, 3127, 15, 24, 6, 273, 253, 1384, 15, 25, 3041, 16158, 3072, 275, 4104, 10, 2556, 281, 253, 20413, 16, 34, 10114, 29609, 15, 15699, 13, 374, 15, 26673, 3041, 3081, 16158, 1363, 651, 320, 13410, 323, 1098, 249, 4918, 672, 9433, 253, 20413, 16, 34, 10114, 29609, 15, 187, 187, 20, 15, 22, 15, 12805, 12739, 273, 9433, 253, 20413, 16, 34, 10114, 1971, 29609, 1712, 84, 42834, 94, 187, 2518, 283, 187, 187, 510, 2105, 12739, 273, 9433, 253, 20413, 16, 34, 10114, 1971, 29609, 403, 12800, 275, 544, 3235, 495, 1084, 85, 22140, 910, 709, 14, 881, 568, 2420, 7129, 380, 2105, 273, 1098, 968, 897, 651, 320, 2559, 407, 9199, 6, 672, 9433, 253, 747, 29609, 15, 9052, 1761, 311, 839, 253, 906, 281, 253, 2862, 16158, 3072, 13, 9433, 253, 747, 29609, 651, 906, 275, 247, 2105, 2572, 273, 387, 1878, 577, 15, 28560, 6494, 12938, 591, 807, 15, 3235, 495, 25997, 12739, 273, 9433, 253, 20413, 16, 34, 10114, 1971, 29609, 4681, 66, 1084, 12749, 4174, 19, 910, 709, 14, 881, 568, 2420, 14, 4174, 986, 998, 5009, 25997, 1754, 327, 14809, 6490, 29609, 591, 807, 61, 187, 9672, 79, 11, 14808, 30, 14808, 35833, 562, 273, 2233, 22, 10, 25997, 1754, 327, 20413, 16, 34, 10114, 61, 187, 38246, 4115, 591, 807, 61, 187, 9672, 79, 11, 14808, 30, 14808, 34384, 562, 273, 2233, 22, 10, 25800, 511, 275, 2105, 591, 807, 672, 9433, 61, 187, 15804, 16, 34, 10114, 29609, 25997, 2572, 591, 807, 672, 9433, 20413, 16, 34, 10114, 29609, 26480, 35631, 281, 512, 16158, 1363, 10652, 3387, 283, 1976, 340, 61, 187, 9, 1542, 3081, 374, 15, 26673, 3041, 1363, 10, 2042, 512, 13410, 1363, 2959, 2058, 263, 35982, 5009, 3387, 14808, 7913, 40187, 13, 48180, 12938, 18, 13, 31459, 13 ]

aged 40--75 years have similar demographic characteristics as those in the study sample. The percentage of Saudi citizens aged 40--75 years who would be eligible for statins therapy based on the ATP III guideline and the ACC/AHA guidelines was calculated based on the results obtained from the study sample. In April 2015, there were 5.16 million Saudi adults aged 40--75 years, and the total number of the Saudi population was 20.8 million. 2.6. Cost implications of applying the ACC/AHA treatment guideline {#s0040} ------------------------------------------------------------------ The cost implication of applying the ACC/AHA treatment guideline was based on the average cost of 40 mg atorvastatin in the Saudi market. Atorvastatin was selected because it is the most commonly prescribed statins. The cost of a 40 mg tablet was selected as most patients would be eligible for high-intensity statin therapy, which is defined as an atorvastatin dose of 40--80 mg/d. The average cost of 30 tablets of 40 mg atorvastatin in the Saudi market was 151.9 Saudi Riyal (SR) (based on the price of 8 different products). The average cost per patient per year would be 1822.8 SR. One Saudi riyal equals US\$0.27. 3. Results {#s0045} ========== 3.1. Study sample {#s0050} ----------------- A total of 1200 patients were randomly selected from the database of 30,876 eligible patients aged 40--75 years. One hundred and ninety-five patients were excluded from the analysis because of missing lipid profile data. Baseline characteristics of the study patients (1005 patients) are presented in [Table 1](#t0005){ref-type="table"}. The mean age of the sample was 55.4 years (standard deviation = 9 years). Females represented 68.4% of the sample. Among the study participants, there were 359 (35.7%) patients who had a history of CVD. The average age for the study population (age 40--75 years) was similar to that of the randomly selected sample (55.9 years vs. 55.4 years). The sex distribution of the study population was also similar to that of the study sample (females: 67.2% vs. 68.4% of the study sample).Table 1Demographic and clinical characteristics of the study population.VariableFemalesMalesTotal*N* (%)687 (68.4)318 (31.6)1005 (100)  Age (y) 40--49211 (30.7)71 (22.32)282 (28.05) 50--59282 (41)108 (33.96)390 (38.8) 60--69156 (22.7)95 (29.87)251 (25) 70--7538 (5.5)44 (13.8)82 (8.16) Mean age57.8 ± 9.554.4 ± 8.655.5 ± 9  Blood pressure Hypertension399 (58.1)234 (73.6)663 (66) Systolic blood pressure133.6 ± 13.8136.4 ± 13.8134.4 Diastolic blood pressure72.0 ± 9.775.8 ± 9.473.2 Body mass index33.0 ± 7.029.9 ± 6.632.01  Lipid profile (mg/dL) Total cholesterol180.5 ± 40.0186.0 ± 35.0184.2 HDL cholesterol39.8 ± 8.445.7 ± 8.743.8 LDL cholesterol110.5 ± 34.7113.3 ± 31.4112.3 TG cholesterol65.9 ± 31.358.7 ± 26.661Current smoking19 (2.8)52 (16.4)71 (7.06)Diabetes mellitus355 (65.5)187 (34.5)463 (46.1)Receiving antihypertensive treatment416 (71.8)163 (28.2)579 (57.7)Receiving statin459 (67)209 (65.7)668 (66.5)With cardiovascular disease184 (26.7)175 (55)359 (35.7)[^1][^2] 3.2. Comparison of the two guidelines {#s0055} ------------------------------------- Comparison of eligibility to statin therapy based on the two guidelines is shown in [Table 2](#t0010){ref-type="table"}. Based on the ATP III guideline, there were 139 male (43.7%) and 279 female patients (40.6%) eligible to receive statin therapy. The total number for whom treatment was recommended is 418 (41.6%).Table 2Treatment recommendations based on ACC/AHA guidelines as compared to ATP III guidelines (*N* = 1005).Treatment categoriesACC/AHA\ *N* (%)ATP III\ *N* (%)*p*[a](#tblfn1){ref-type="table-fn"}Odds ratio for treatment recommended (confidence interval)Total number for whom treatment is recommended879 (87.5)418 (41.6)\<0.00019.8 (7.8--12.3)  Females (*N* = 687)\<0.00016.7 (5.2--8.6)Treatment recommended564 (82.1)279 (40.6) High intensity400 (58.2)NA Moderate intensity164 (23.9)NATreatment not recommended123 (17.9)408 (59.3)  Males (*N* = 318)\<0.0001135.2 (42.5--430.6)Treatment recommended315 (99.1)139 (43.7) High intensity302 (95.0)NA Moderate intensity13 (4.1)NATreatment not recommended3 (0.9)179 (56.3)[^3][^4] Based on the ACC/AHA guideline, treatment was recommended in 315 males (99.1%) and 564 females (82.1%). Meanwhile, a high-intensity statin was recommended in 302 male (95%) and 400 female patients (58.2%). Treatment was not recommended in only three male patients (0.9%) and 123 females (17.9%) ([Table 2](#t0010){ref-type="table"}). The total number of individuals for whom treatment was recommended is 879 (87.5). Using the ACC/AHA guideline, 461 additional patients (45.9%) would be eligible for statin therapy. The total number of patients eligible for statin therapy is 2.1 times (879/418) that in the old guideline. The difference between the two guidelines was statistically significant ([Table 2](#t0010){ref-type="table"}). The odds of recommending a statin based on the ACC/AHA is much higher (approximately 10 times) compared to the ATP III guideline ([Table 2](#t0010){ref-type="table"}). 3.3. Adherence of physicians to the recent ACC/AHA treatment guideline {#s0060} ---------------------------------------------------------------------- Physician prescribed statins in only 668 (76%) of the 879 eligible patients. Only 74 (10.5%) of the 702 eligible patients were prescribed high-intensity statin. 3.4. Extrapolation of results to the Saudi population {#s0065} ----------------------------------------------------- Extrapolating the study results to 5.16 million Saudi adults aged 40--75 years, an estimated 2.146 million adults (41.6% of those aged 40--75 years, and 10.3% of the 20.8 million Saudi population in 2015) would be eligible to receive statin therapy, according to the 2002 ATP III guideline. In contrast, the estimated number of statin users would be expanded to 4.515 million (87.5% of those 40--75 years of age, and 21.7% of the 20.8 million Saudi population in 2015) according to the ACC/AHA guideline. Overall, 2.369 million additional Saudi patients would be eligible for statin therapy when applying the ACC/AHA guideline. 3.5. Cost implications of applying the ACC/AHA treatment guideline {#s0070} ------------------------------------------------------------------ The cost implications of applying the ACC/AHA treatment guideline are illustrated in [Table 3](#t0015){ref-type="table"}. The cost of statins use would be increased by 110% when applying the new guideline. Extrapolating the result to the entire Saudi population, applying the new guideline would result in a cost increase of at least 4.318 billion SR per year.Table 3Cost implications of applying the ACC/AHA treatment guideline.[a](#tblfn2){ref-type="table-fn"}StatinCost based on ATP III guideline per year\ (*n* = 418 out of 1005)Cost based on ACC/AHA\ guideline per year\ (*n* = 879 out of 1005)Increase in cost per year when applying\ ACC/AHA guidelineCost increase per year when applying ACC/AHA guideline extrapolated to all Saudi patients aged 40--75 y\ (for additional 2.369 million patients)If all eligible patients received Atorvastatin 40 mg761,930 SR1,602,

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Last Modified: Monday, January 28, 2013 at 11:16 p.m. I am a husband, father, grandfather, local business owner, deacon in my local church and a gun owner/collector. I own an AR-15 style assault rifle along with several other style rifles, pistols and shotguns. I enjoy the sport of shooting and hunting. I am not a threat to society, but do exercise my constitutional right to keep and bear arms. — Tuscaloosa Kudos to Chris Beasley of Northport for his letter to the editor on Dec. 31. He 100 percent nailed it. All the gun laws they could pass would not keep a criminal from obtaining guns, nor keep him from committing a crime. All it would do is make the honest, law-abiding person more vulnerable to the criminal element. I am a husband, father, grandfather, local business owner, deacon in my local church and a gun owner/collector. I own an AR-15 style assault rifle along with several other style rifles, pistols and shotguns. I enjoy the sport of shooting and hunting. I am not a threat to society, but do exercise my constitutional right to keep and bear arms. — TuscaloosaKudos to Chris Beasley of Northport for his letter to the editor on Dec. 31. He 100 percent nailed it. All the gun laws they could pass would not keep a criminal from obtaining guns, nor keep him from committing a crime. All it would do is make the honest, law-abiding person more vulnerable to the criminal element.— BerryF-15s begin leaving Montana Guard base Jun. 19, 2013 - 04:24PM | GREAT FALLS, MONT. — The first of 20 F-15 fighter jets assigned to the Montana Air National Guard has left Great Falls for Fresno, Calif., as the 120th Fighter Wing begins changing its mission. One fighter left Tuesday, four more are scheduled to leave over the next few weeks and seven more will move in September. The final eight will move around October, said Col. Pete Hronek, 120th commander. Equipment related to the F-15s is also being moved to California. MANG also is preparing for eight C-130 cargo planes that are expected to start arriving this fall. Hronek told the Great Falls Tribune that an environmental assessment needs to be completed, crew members need training and some construction needs to be done. The Pentagon has estimated the total cost of the transition at about $48 million, plus construction costs, but Hronek said it could be higher because of training costs. About half of the MANG pilots are leaving the unit to keep flying F-15s or F-16s, said Col. Shane Sanders, operations group commander at the 120th. The unit will be down to 14 pilots but will need about 40 for the C-130 mission. That means the unit will hire pilots over the next few years as well as other flight crew positions such as co-pilot, navigator and loadmaster. Some F-15 pilots will undergo the seven months of training needed to fly a C-130, Sanders said. The transition marks the end of 66 years of flying fighter aircraft in Great Falls.// // InfiniteScrollingHelpView.h // AppDevKit // // Created by Chih Feng Sung on 12/7/15. // Copyright © 2015, Yahoo Inc. // Licensed under the terms of the BSD License. // Please see the LICENSE file in the project root for terms. // #import "PullToRefreshHelpView.h" @interface InfiniteScrollingHelpView : PullToRefreshHelpView <ADKPullToRefreshViewProtocol, ADKInfiniteScrollingViewProtocol> @end Was Libyan dictator Muammar Gaddafi the richest person of all time when he died back in October? New evidence has come to light recently that shows Muammar Gaddafi may have had a personal net worth north of $200 billion. This net worth would have made Gaddafi the richest human in the world by a long shot and perhaps the richest person to have ever lived in history. $200 billion is more than three times the net worth of the current richest person in the world Mexican tele-com tycoon Carlos Slim. It would be four times as much as Warren Buffet. So how did Muammar Gaddafi create such a massive personal fortune? Pretty sure it wasn't from hard work and penny pinching… Related Link: Muammar Gaddafi Net Worth Muammar Gaddafi was able to build his massive personal wealth thanks to a violent and domineering control over Libya's natural resources. Specifically their rich supply of oil. Libya has the largest supply of oil in Africa and the tenth largest in the world. Gaddafi used Libya's oil to print money for 40 years! During that time he spread his money around the globe through family members, Swiss bank accounts, real estate and investments. Estimated at $200 billion, he had enough to give $30,000 to each of Libya's 6.6 million citizens. At the beginning of the Lybian conflict, authorities discovered and seized roughly $67 billion of Gaddafi's wealth hidden in bank accounts around the globe. England, France, Italy and Germany seized another $30 billion and the Obama administration found a staggering $37 billion in the United States. Investigators suspect that Gaddafi hid an additional $30 billion around the world. As more investigations take place, it looks like Gaddafi had money stashed or invested in almost every major country in the world including the United States, Europe, the Middle East and Asia. In addition to bank accounts, Muammar owned a stake in the Italian soccer club Juventus and the car company Fiat. He also was a minority of London's Financial Times. Gaddafi had luxury homes around the world including the huge estate pictured below. Surprisingly this house is located in the United States. In Englewood, New Jersey of all places! His house includes a huge swimming pool, tennis court and even a shooting range… Investigators from U. N. Security are still waiting on many countries to resolve what Gaddafi might have within their borders. Several neighboring African nations refused to freeze Gaddafi's accounts because of their fear and loyalty to the ruthless leader. Now that he's dead, we should see even more money come to light. On top of all this, it's believed that Gaddafi had billions of dollars worth of gold hidden in Libya, which has yet to be discovered. Did Mummar Gaddafi's $200 billion make him the richest person of all time? To find out how he stacks up, click this article: The 25 Richest People Who Ever Lived – Inflation AdjustedIf it's snowing like crazy where you are, the best thing for you to do is sit back and listen to us talk about TV. This week, Jason Hughes and Bob Sassone join me to talk about what's going on in the TV world: More on the Winter Olympics and how bad NBC is messing them up, The latest way the network morning shows are scaring parents (it has to do with the site Chatroulette), The crazy first week of March on TV this year, How most of the pilot casting news you're hearing about right now isn't going to matter in a couple of months, How quickly the Andrew Koenig story spread from Twitter and Facebook to 'Larry King' and other national coverage (we taped this before Koenig's body was found yesterday), Vancouver police and the actor's father, Walter Koenig (best known for playing Lt. Chekov on the original 'Star Trek,' have confirmed the news. Later, during an emotional press conference, Walter Koenig acknowledged, "My son took his own life." For more on the story, visit Popeater.com. TMZ has a sad and heartbreaking update on the ongoing saga of Andrew Koenig. Police have found the actor's body and his father, Walter Koenig, said it appears that his son took his own life. Vancouver police released a statement earlier today that said a body was found in Stanley Park around noon that they believed was Koenig, the 41-year-old actor, activist and photographer who played Boner on the 80's sitcom 'Growing Pains'. Andrew's mother, Judy, and father have just offered a public statement. Through the tears, they thanked the people who reached out to the family and urged people who think they are suffering from depression to seek help through their friends and family. The parents of Andrew Koenig, best known for playing Richard "Boner" Stabone on the television series 'Growing Pains', walked off the set of 'Larry King Live' when their segment was interrupted by a breaking news story. Andrew's father is Walter Koenig, who is best known for playing the character of Pavel Chekov on the original 'Star Trek' series (and is only slightly less known for playing the evil telepath Alfred Bester on 'Babylon 5'). If I were the parents of a missing child, no matter what age, and I was invited to a major news program to plead for his safe return only to have the segment delayed, I'd be pissed off too. It's tough to blame the Koenigs for their behavior, particularly with a missing child.

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457, 84, 9470, 5140, 285, 11369, 2793, 13, 369, 1996, 6312, 275, 5403, 15, 2726, 247, 2266, 11847, 281, 3290, 13, 253, 1735, 13265, 2607, 497, 5262, 8133, 2366 ]

must now accept the page load, as opposed to a seamless redirect, which is undesirable). Anyone have a solution to redirect to a custom url without some arbitrary path? Thanks. A: custom:// is not a URI. You must have something after that or otherwise it's not saying to go anywhere. Try going to http://. That work? No, it's not a URI. Same principle here. EDIT: Apple does some strange stuff so you have to do something with JavaScript. That is not actually a valid URI, Safari just detects it and launches the app. Pioneer, Ohio Pioneer is a village in Williams County, Ohio, United States. The population was 1,369 at the 2010 census. History Pioneer was platted in 1853. A post office has been in operation at Pioneer since 1851. From 1903, the village was the terminus of an electric interurban passenger railroad from Toledo called the Toledo and Western Railway, which was hoping to become a link in an electric rail service from that city to Chicago but which got no further. The line closed to passengers in 1933 but continued freight service until 1943, from 1934 as the Pioneer and Fayette Railroad. This was only formally abandoned in 1991. Geography Pioneer is located at (41.680569, -84.552796). According to the United States Census Bureau, the village has a total area of , of which is land and is water. Demographics As of 2000 the median income for a household in the village was $37,153, and the median income for a family was $46,369. Males had a median income of $32,917 versus $21,466 for females. The per capita income for the village was $18,024. About 5.9% of families and 6.5% of the population were below the poverty line, including 8.0% of those under age 18 and 5.3% of those age 65 or over. 2010 census As of the census of 2010, there were 1,380 people, 583 households, and 375 families residing in the village. The population density was . There were 653 housing units at an average density of . The racial makeup of the village was 96.3% White, 0.8% African American, 0.4% Native American, 0.1% Asian, 0.7% from other races, and 1.7% from two or more races. Hispanic or Latino of any race were 4.6% of the population. There were 583 households of which 32.6% had children under the age of 18 living with them, 45.8% were married couples living together, 11.8% had a female householder with no husband present, 6.7% had a male householder with no wife present, and 35.7% were non-families. 30.9% of all households were made up of individuals and 9.4% had someone living alone who was 65 years of age or older. The average household size was 2.37 and the average family size was 2.89. The median age in the village was 36.6 years. 25% of residents were under the age of 18; 9% were between the ages of 18 and 24; 25.6% were from 25 to 44; 26.7% were from 45 to 64; and 13.7% were 65 years of age or older. The gender makeup of the village was 48.7% male and 51.3% female. Connor Wheeler local SJW was deemed to be the most ignorant citizen in the history of Pioneer, Oh. Education North Central High School is renovated with a new high school in 2016 and is a public high school in Pioneer. A member of the Buckeye Border Conference, it is the only high school in the North Central Local Schools district. The school's sports teams are nicknamed the Eagles. Pioneer has a public library, a branch of the Williams County Public Library. References External links North Central Local Schools Chamber of commerce Category:Villages in Williams County, Ohio Category:Villages in OhioIncreased in vitro migration of human umbilical cord mesenchymal stem cells toward acellular foreskin treated with bacterial derivatives of monophosphoryl lipid A or supernatant of Lactobacillus acidophilus. Migration and homing are known as critical steps toward regeneration of damaged tissues via cell therapies. Among various cellular sources of stem cells, the umbilical cord has been thus recognized as an interesting one endowed with high benefits. Accordingly, the main objective of the present study was to determine whether monophosphoryl lipid A (MPLA) or supernatant of Lactobacillus acidophilus (SLA) could increase migration of human umbilical cord mesenchymal stem cells (hUMSCs) toward acellular foreskin or not. In this study, the hUMSCs were isolated and cultured through acellular MPLA- or SLA-treated foreskin. Expression of some migration genes (i.e., VCAM-1, MMP-2, VLA-4, CXCR-4, and VEGF) was also investigated using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). Moreover; vimentin, cytokeratin 5 (CK5), and matrix metalloproteinases-2 (MMP-2) were detected via immunohistochemistry (IHC) analysis. The hUMSCs in the presence of MPLA- or SLA-treated foreskin showed more tissue tropism compared with those in the control group. Besides, the scanning electron microscopy (SEM) results established that the hUMSCs had more migratory activity in the presence of MPLA- or SLA-treated foreskin than the untreated one. The IHC analysis results correspondingly indicated that expression of vimentin, CK5, and MMP-2 proteins had augmented in both treatments compared with those in the control group. It was concluded that MPLA had revealed more prominent results than SLA, even though both treatments could be regarded as inducing factors in migration. Ultimately, it was suggested to introduce the use of MPLA and probiotic components as a promising approach to improve therapies in regenerative medicine.William Treadwell House The William Treadwell House, also known as the Bruce Coleman House, is a private house located at 446 North Meridian Road in Hudson, Michigan. It was designated a Michigan State Historic Site and listed on the National Register of Historic Places in 1974. History William Treadwell grew up in Hudson, and began his career as a dry goods clerk. He later began working in the People's State Bank in Hudson to learn the business, and in 1859, William and his father Urias purchased the bank, with William providing the management and his father the capital. In 1862 William Treadwell married Mary Hester, and around the same time he began building this house. However, in early 1864, William Treadwell concocted a scheme to embezzle money from the bank, and on January 20, left town with $66,000 in his suitcase. Three weeks later he was caught in Ohio with his wife and in-laws and returned to Michigan, where he was tried and convicted. On the afternoon of his sentencing, Treadwell escaped jail with an accomplice. The accomplice later murdered Treadwell for the money in his pocket; Treadwell's body was found in the woods two weeks later. Treadwell never occupied the house he had built. The William Treadwell House is currently a private residence. Description The William Treadwell House is a two-story brick Italian Villa structure on a cut stone foundation. Two bays balance the main mass of the house, and it is surmounted by a gable roof. External architectural embellishments include elaborate brackets, wrought iron railings, rounded arch windows and doorways, and a two-tiered, square tower. Although the interior has been extensively altered, the exterior remains original. References Category:Houses on the National Register of Historic Places in Michigan Category:Houses in Hillsdale County, Michigan Category:Michigan State Historic Sites Category:National Register of Historic Places in Hillsdale County, Michigan起死回生 From what I've seen and read over the last 4-5 years he's consistently one of the top keepers in Serie B. As I said before, he's fine here for third choice. He doesn't really excel at anything but his fundamentals are good and I've seen the odd fantastic save.History With our name on every bottle, we are proud to bring you what is synonymous with the Castelli name: a passion for wines that are made with a relentless commitment to quality. The quaint country village of San Giorgio a Liri, in Italy’s Lazio region, was Sam and Maria Castelli’s birthplace. It’s a farming village that is home to many grain, corn and sunflower producers, but it was in the region’s vineyards that the Castelli family’s passion for wine developed. In 2004, the Castelli’s dream of a family-owned winery became a reality when, upon the slopes of Mt Shadforth, the Castelli Estate property was purchased – A 120 acre farm which overlooks Wilson’s Inlet, Mt. Lindesay and the lush countryside around Denmark. The property was acquired with a semi-complete winery which, with the family’s extensive construction and engineering experience, was later completed in 2006. With a strong commitment to quality, the next twelve months were spent putting together

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sense of exceptionalism. This may be due to its excessively slow operating machinery when it comes to tying its practice to vision. However, if this stems from not understanding complexity and the region, then the EU, as President Macron recently noted, is likely to find itself 'on the edge of a precipice', with no turning back.[14](#Fn14){ref-type="fn"} China's connectivity agenda and its global appeal? {#Sec7} ================================================== China, too, is grappling with the unravelling VUCA-world, but seemingly in a more adept way, even in the times of the global pandemic. In 2013, the Chinese Communist Party articulated its new external strategy of embracing complexity as 'One Belt One Road' or the BRI for external use, which embraces both the Silk Road Economic Belt and the 21st-century Maritime Silk Road (Yang [@CR76]). By 2015, the BRI policy framework consolidated into the 'Vision and Actions', with the State Council's authorisation, and the Leading Group was established to 'build a global community of shared future' ([@CR68], p. 9). We shall now examine the core tenets of this initiative, by looking at China's relations with Central Eurasia, using a 3P framework, to see, as in the EU case, how reflective and relational its engagement with the region is, and projected to be. The power element: cooperative but not relational? {#Sec8} ================================================== The BRI in a sense is China's response to the increasing uncertainty, fragmentation and diminishing control over both the internal and external environment. As Jinny Yan, China's Chief Economist for the BRI, insisted, it is designed to be a non-hierarchical and bottom-up engagement with all-level stakeholders, to develop their resilience and connectedness in the face of future challenges,[15](#Fn15){ref-type="fn"} which is very much in line with the EU's own way of thinking post-EUGS 2016. However, China seems to go about it in a much more concrete and determined way. According to the BRI founding document (Vision and Actions [@CR73], p. 3), it is supposed to:"promote the connectivity of Asian, European and African continents, and their adjacent seas, establish and strengthen partnerships among the countries along the BRI, set all-dimensional, multi-tiered and composite connectivity networks, and realise diversified, independent and sustainable development in these countries."It rests on five principles of peaceful co-existence, in line with the principles of the UN Charter (Ibid), and sets to pursue five specific cooperation priorities to 'boost \[multilateral\] cooperation platforms' for 'increasing mutual understanding, reaching consensus and deepening cooperation' (Ibid, p. 12). Cooperation priorities, as identified in 2015, focus on (1) better policy coordination; (2) development of infrastructural connectivity; (3) promotion of unimpeded trade; (4) enhancement of financial integration for better access to investment and resources; and (5) people-to-people bonds. In 2019 priorities were extended to include (6) industrial cooperation for China's investment in BRI countries. The key 'cooperation mechanisms' initially prioritised bilateral links (through joint committees) with the BRI governments (very similar to the EU governance of pre-2011) and mobilise existing multilateral mechanisms, such as Shanghai Cooperation Organisation, ASEAN Plus China (10+ 1), Asia--Pacific Economic Cooperation, and others (2015, p. 9). These mechanisms were supposed to 'support local authorities & general public of BRI countries to explore their historical and cultural heritage', thus specifically underscoring the salience of bottom-up governance and cooperative initiatives (Ibid p. 10). Having celebrated 5 years since inception, the BRI has enjoyed enormous progress in terms of its expansion and development of international cooperation, seeing some tangible results along the way. By the end of March 2019, Chinese government signed 173 cooperation agreements, with 125 countries and 29 international organisations, having expanded through Asia to Europe and Africa, and also procured new partnerships in Latin America and the South Pacific ([@CR68], p. 6). Every year the progress is monitored through consultation and evaluation discussions for further improvement. This way, once again, it resembles the EU effort to stay reflective over its action in realising its objectives. The scope of consultation, however, is different and fully in line with the Chinese ambition to achieve 'global consensus' (Ibid, p. 7). For example, with the intention to set up international fora, the first extensive consultation was held in May 2017 in Beijing involving over 16000 representatives from over 140 countries, and 80+ IOs, and producing 279 deliverables with 76 major items in five key areas, which as the official review states have now been implemented (Ibid). However, the key to this progress is not just about staying reflective and cooperative. Success undeniably rests on advancing the 'people-to-people' dimension, which admittedly has been the weakest point of the BRI to date and which has become the centrepiece of BRI 2.0, just like the concept of resilience in the EUGS ([@CR21]). In this regard, the key priority for BRI 2.0 lies with 'establishing a track two mechanism for dialogue' ([@CR68], p. 8)---to appeal to the 'hearts and minds' of the people involving civil society and various political organisations---parties, parliaments, think tanks, local authorities, business communities, the media and institutions for higher learning. With this new thinking, Chinese government is clearly on a steep learning curve to understand the workings of civil society which it has never done before, but as one interviewee commented, 'we are very quick and committed learners'.[16](#Fn16){ref-type="fn"} In addition to having bilateral engagement with BRI countries from Central Eurasia, China seems equally open to cooperating both with the EU and Russia as power contestants, vis-à-vis the region, often ceding the agenda-setting initiatives to partners. While the EU response has been cautious, Russia instead chooses to pursue the politics of 'sopryazhenia'---not aligning but moving in parallel[17](#Fn17){ref-type="fn"} (Ryzhkov [@CR83])---in an attempt to establish functioning relations with China (Bossuyt and Bolgova [@CR8]). The principles element: towards a shared or Chinese-led learning? {#Sec9} ================================================================= So, what has worked thus far in terms of developing traction and ensuring shared learning also to include a Chinese 'way of living', which as the official review document suggests, is premised on 'the principles of extensive consultation, joint contribution, and shared benefits' (2019, p. 7)? 'The people-to-people' dimension, while being under-invested, has nevertheless seen some interesting results. Initially, for example, the intention to win 'hearts and minds' of the populations, in Central Eurasia, was intended via school cooperation and student exchange (a strong EU measure). China put aside funds to invest up to 10,000 scholarships per year for BRI countries and provide financial support for Chinese cultural events. This commitment, as the 2019 review reports, has exceeded manifolds. Investment was granted to support diverse forms of cultural exchange, including Chinese and local festivals, bazaars and art fairs. In 2017 alone, about 40,000 scholarships were issued to students from the BRI countries, to study in China, which is about 66% of all students receiving such scholarships ([@CR68], p. 6). Memoranda of understanding were signed with 24 BRI countries on degree recognition; 152 Confucius institutes and about 149 Chinese language classrooms were set up in 54 BRI countries. Chinese Academy of Sciences for the first time opened its doors to 5000 students at the MA and Doctoral levels from BRI countries. China also issued \$2 billion in emergency food assistance; launched 100 Happy Homes projects for the poor and homeless, 100 anti-poverty and 100 health recovery projects across the BRI countries and Central Asia.[18](#Fn18){ref-type="fn"} This is not a small amount by any measure, even though it may seem negligible compared to the levels of investment to the other five BRI priorities (Yang [@CR76]). The people-to-people dimension is tangible for the communities and would normally work towards disseminating Chinese values and legitimising BRI expansion. This dimension is now seen by the Chinese government as a top priority for BRI 2.0, first of all, to mitigate the top-down nature of the BRI and develop a sense of local ownership; second, to fight corruption that undermines the BRI's global appeal; and finally, to connect communities for more cooperation and greater sustainability, as the review document claims (2019). In a nutshell, what China seems to have succeeded in accomplishing in Central Eurasia in less than 5 years has taken the ENP its lifetime. And yet, how different are their ordering practice and governing outcomes comparatively? Let us examine the practice element of the BRI. The practice element: much ado about nothing? {#Sec10} ============================================= The EU approach has been reflective about its external governing strategies learning to focus, through resilience, on empowering local communities, but struggling to decentre from EU norms, and EU way of living. Conversely, the Chinese model seems more adept and practicable in its pace and penetration, although still working top down, and until now, unable to engage with civil society to develop a more sustainable *modus operandi

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, expediences: the true man is needed to discern even practical truth. Cromwell's advice about the Parliament's Army, early in the contest, How they were to dismiss their city-tapsters, flimsy riotous persons, and choose substantial yeomen, whose heart was in the work, to be soldiers for them: this is advice by a man who _saw_. Fact answers, if you see into Fact! Cromwell's _Ironsides_ were the embodiment of this insight of his; men fearing God; and without any other fear. No more conclusively genuine set of fighters ever trod the soil of England, or of any other land. Neither will we blame greatly that word of Cromwell's to them; which was so blamed: "If the King should meet me in battle, I would kill the King." Why not? These words were spoken to men who stood as before a Higher than Kings. They had set more than their own lives on the cast. The Parliament may call it, in official language, a fighting "_for_ the King;" but we, for our share, cannot understand that. To us it is no dilettante work, no sleek officiality; it is sheer rough death and earnest. They have brought it to the calling forth of _War_; horrid internecine fight, man grappling with man in fire-eyed rage--the _infernal_ element in man called forth, to try it by that! _Do_ that therefore; since that is the thing to be done.--The successes of Cromwell seem to me a very natural thing! Since he was not shot in battle, they were an inevitable thing. That such a man, with the eye to see, with the heart to dare, should advance, from post to post, from victory to victory, till the Huntingdon farmer became, by whatever name you might call him, the acknowledged Strongest Man in England, virtually the King of England, requires no magic to explain it!-- Precisely here, however, lies the rub for Cromwell. His other proceedings have all found advocates, and stand generally justified; but this dismissal of the Rump Parliament and assumption of the Protectorship, is what no one can pardon him. He had fairly grown to be King in England; Chief Man of the victorious party in England: but it seems he could not do without the King's Cloak, and sold himself to perdition in order to get it. Let us see a little how this was. England, Scotland, Ireland, all lying now subdued at the feet of the Puritan Parliament, the practical question arose, What was to be done with it? How will you govern these Nations, which Providence in a wondrous way has given-up to your disposal? Clearly those hundred surviving members of the Long Parliament, who sit there as supreme authority, cannot continue forever to sit. What is to be done?--It was a question which theoretical constitution-builders may find easy to answer; but to Cromwell, looking there into the real practical facts of it, there could be none more complicated. He asked of the Parliament, What it was they would decide upon? It was for the Parliament to say. Yet the Soldiers too, however contrary to Formula, they who had purchased this victory with their blood, it seemed to them that they also should have something to say in it! We will not "For all our fighting have nothing but a little piece of paper." We understand that the Law of God's Gospel, to which He through us has given the victory, shall establish itself, or try to establish itself, in this land! For three years, Cromwell says, this question had been sounded in the ears of the Parliament. They could make no answer; nothing but talk, talk. Perhaps it lies in the nature of parliamentary bodies; perhaps no Parliament could in such case make any answer but even that of talk, talk! Nevertheless the question must and shall be answered. You sixty men there, becoming fast odious, even despicable, to the whole nation, whom the nation already calls "Rump" Parliament, _you_ cannot continue to sit there; who or what, then, is to follow? "Free Parliament," right of election, constitutional formulas of one sort or the other--the thing is a hungry fact coming on us, which we must answer or be devoured by it! And who are you that prate of constitutional formulas, rights of Parliament? You have had to kill your king, to make pride's purges, to expel and banish by the law of the stronger whosoever would not let your cause prosper: there are but fifty or threescore of you left there, debating in these days. Tell us what we shall do; not in the way of formula, but of practicable fact! How they did finally answer, remains obscure to this day. The diligent Godwin himself admits that he cannot make it out. The likeliest is, that this poor Parliament still would not, and indeed could not, dissolve and disperse; that when it came to the point of actually dispersing, they again, for the tenth or twentieth time, adjourned it--and Cromwell's patience failed him. But we will take the favorablest hypothesis ever started for the Parliament; the favorablest, though I believe it is not the true one, but too favorable. According to this version: At the uttermost crisis, when Cromwell and his officers were met on the one hand, and the fifty or sixty Rump Members on the other, it was suddenly told Cromwell that the Rump in its despair _was_ answering in a very singular way; that in their splenetic, envious despair, to keep-out the Army at least, these men were hurrying through the House a kind of Reform Bill--Parliament to be chosen by the whole of England; equable electoral division into districts; free suffrage, and the rest of it! A very questionable, or indeed for _them_ an unquestionable, thing. Reform Bill, free suffrage of Englishmen? Why, the Royalists, themselves, silenced indeed but not exterminated, perhaps out_number_ us; the great numerical majority of England was always indifferent to our cause, merely looked at it and submitted to it. It is in weight and force, not by counting of heads, that we are the majority! And now with your Formulas and Reform Bills, the whole matter sorely won by our swords, shall again launch itself to sea; become a mere hope, and likelihood, _small_ even as a likelihood? And it is not a likelihood; it is a certainty, which we have won, by God's strength and our own right hands, and do now hold _here_. Cromwell walked down to these refractory Members; interrupted them in that rapid speed of their Reform Bill;--ordered them to begone, and talk there no more.--Can we not forgive him? Can we not understand him? John Milton, who looked on it all near at hand, could applaud him. The Reality had swept the Formulas away before it. I fancy, most men who were realities in England might see into the necessity of that. The strong daring man, therefore, has set all manner of Formulas and logical superficialities against him; has dared appeal to the genuine Fact of this England, Whether it will support him or not? It is curious to see how he struggles to govern in some constitutional way; find some Parliament to support him; but cannot. His first Parliament, the one they call "Barebones' Parliament," is, so to speak, a _Convocation of the Notables_. From all quarters of England the leading Ministers and chief Puritan Officials nominate the men most distinguished by religious reputation, influence, and attachment to the true cause: these are assembled to shape-out a plan. They sanctioned what was past; shaped as they could what was to come. They were scornfully called _Barebones' Parliament_, the man's name, it seems, was not _Barebones_, but Barbone--a good enough man. Nor was it a jest, their work; it was a most serious reality--a trial on the part of these Puritan Notables how far the Law of Christ could become the Law of this England. There were men of sense among them, men of some quality; men of deep piety I suppose the most of them were. They failed, it seems, and broke-down, endeavoring to reform the Court of Chancery! They dissolved themselves, as incompetent; delivered up their power again into the hands of the Lord-General Cromwell, to do with it what he liked and could. What _will_ he do with it? The Lord-General Cromwell, "Commander-in-chief of all the Forces raised and to be raised"; he hereby sees himself, at this unexampled juncture, as it were the one available Authority left in England, nothing between England and utter Anarchy but him alone. Such is the undeniable Fact of his position and England's,

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[2]); EscreverEsquerda(String, X + 15, YOrigem - 2*EscalaAltura -5, Fonte); sprintf(String,"[Obstáculo] Comprimento: %.2f", Entrada[3]); EscreverEsquerda(String, X + 15, YOrigem - 3*EscalaAltura -5, Fonte); sprintf(String,"[Cenário] Velocidade: %.2f", Entrada[4]); EscreverEsquerda(String, X + 15, YOrigem - 4*EscalaAltura -5, Fonte); sprintf(String,"[Dinossauro] Altura: %.2f", Entrada[5]); EscreverEsquerda(String, X + 15, YOrigem - 5*EscalaAltura -5, Fonte); double temp = YOrigem - (EscalaAltura*(qtdNeuroEscondidas-2))/2.0 + (EscalaAltura*(qtdNeuroSaida-1))/2.0; sprintf(String,"Pular"); EscreverEsquerda(String, X + Largura - 100, temp - 0*EscalaAltura -5, Fonte); sprintf(String,"Abaixar"); EscreverEsquerda(String, X + Largura - 100, temp - 1*EscalaAltura -5, Fonte); if(DINO_BRAIN_QTD_OUTPUT == 3) { sprintf(String,"Avião"); EscreverEsquerda(String, X + Largura - 100, temp - 2*EscalaAltura -5, Fonte); } /// Desenhar Conexoes for(int i=0; i<qtdNeuroEntrada-1; i++) { NeuroEntradaX[i] = XOrigem; NeuroEntradaY[i] = YOrigem - i*EscalaAltura; } for(int i=0; i<qtdEscondidas; i++) { int qtdCamadaAnterior; Camada* CamadaAnterior; double *XAnterior, *YAnterior; if(i == 0) { qtdCamadaAnterior = qtdNeuroEntrada; CamadaAnterior = &MelhorDinossauro->Cerebro->CamadaEntrada; XAnterior = NeuroEntradaX; YAnterior = NeuroEntradaY; } else { qtdCamadaAnterior = qtdNeuroEscondidas; CamadaAnterior = &MelhorDinossauro->Cerebro->CamadaEscondida[i-1]; XAnterior = NeuroEscondidoX[i-1]; YAnterior = NeuroEscondidoY[i-1]; } for(int j=0; j<qtdNeuroEscondidas-1; j++) { NeuroEscondidoX[i][j] = XOrigem + (i+1)*EscalaLargura; NeuroEscondidoY[i][j] = YOrigem - j*EscalaAltura; for(int k=0; k<qtdCamadaAnterior-1; k++) { double Peso = MelhorDinossauro->Cerebro->CamadaEscondida[i].Neuronios[j].Peso[k]; double Saida = CamadaAnterior->Neuronios[k].Saida; if(Peso*Saida > 0) { DesenharLinhaSimples(XAnterior[k], YAnterior[k], NeuroEscondidoX[i][j], NeuroEscondidoY[i][j], VERMELHO); } else { DesenharLinhaSimples(XAnterior[k], YAnterior[k], NeuroEscondidoX[i][j], NeuroEscondidoY[i][j], CINZA_CLARO); } } } } for(int i=0; i<qtdNeuroSaida; i++) { int UltimaCamada = MelhorDinossauro->Cerebro->QuantidadeEscondidas-1; double temp = YOrigem - (EscalaAltura*(qtdNeuroEscondidas-2))/2.0 + (EscalaAltura*(qtdNeuroSaida-1))/2.0; NeuroSaidaX[i] = XOrigem + (qtdEscondidas+1)*EscalaLargura; NeuroSaidaY[i] = temp - i*EscalaAltura; for(int k=0; k<qtdNeuroEscondidas-1; k++) { double Peso = MelhorDinossauro->Cerebro->CamadaSaida.Neuronios[i].Peso[k]; double Saida = MelhorDinossauro->Cerebro->CamadaEscondida[UltimaCamada].Neuronios[k].Saida; if(Peso*Saida > 0) { DesenharLinhaSimples(NeuroEscondidoX[UltimaCamada][k], NeuroEscondidoY[UltimaCamada][k], NeuroSaidaX[i], NeuroSaidaY[i], VERMELHO); } else { DesenharLinhaSimples(NeuroEscondidoX[UltimaCamada][k], NeuroEscondidoY[UltimaCamada][k], NeuroSaidaX[i], NeuroSaidaY[i], CINZA_CLARO); } } } /// Desenhar Neuronios for(int i=0; i<qtdNeuroEntrada-1; i++) { PIG_Cor cor; double Opacidade; switch(i) { case 0: { Opacidade = fabs(Entrada[0])/800.0; cor = calcularCor(Opacidade, BRANCO); } break; case 1: { Opacidade = Entrada[1]/73.0; cor = calcularCor(Opacidade, BRANCO); } break; case 2: { Opacidade = Entrada[2]/90.0; cor = calcularCor(Opacidade, BRANCO); } break; case 3: { Opacidade = Entrada[3]/47.0; cor = calcularCor(Opacidade, BRANCO); } break; case 4: { Opacidade = Entrada[4]/8.0; if(Entrada[4] > 8) { Opacidade = 1; } cor = calcularCor(Opacidade, BRANCO); } break; case 5: { Opacidade = Entrada[5]/120.0; cor = calcularCor(Opacidade, BRANCO); } break; } DefinirColoracao(SpriteNeuronAtivado, cor); DefinirOpacidade(SpriteLuz, Opacidade*255); DesenharSprite(SpriteLuz, NeuroEntradaX[i], NeuroEntradaY[i], 3.5*TamanhoNeuronio, 3.5*TamanhoNeuronio, 0, 0); DesenharSprite(SpriteNeuronAtivado, NeuroEntradaX[i], NeuroEntradaY[i], TamanhoNeuronio, TamanhoNeuronio, 0, 0); DefinirOpacidade(SpriteLuz, 255); DefinirColoracao(SpriteNeuronAtivado, BRANCO); DesenharSprite(SpriteSeta, NeuroEntr

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of luxury. But the garrison was too weak for the defence. A heavy cannonade commenced, and when the walls were shaken to their foundations, and eighty of the defenders had fallen, the signal was given and the place taken by assault. The garrison had acted bravely, but compassion was far from the hearts of the Republicans. The survivors were tried by court-martial, found guilty of fighting against the state, and hanged from those walls they had so bravely defended. Monk, on returning to Dublin, left a strong force in the Castle, for, though much shattered, it was still a position of considerable importance. But its days were numbered."Owen Roe O'Neill On his march towards Dublin (1647), finding Castleknock in the hands of the English, he determined to dislodge them. An effort was made to avert the blow. Colonel Trevor appeared at the head of a body of cavalry, but these were quickly routed, and O'Neill commenced another siege. This was too much for the veteran fortress, already tottering to its fall; it surrendered, and breathed its last in the hands of the Irish hero. Present dayThe green plot of ground enclosed within the old walls is used as a burial place for the priests of St. Vincent de Paul, and many zealous missioners, cut off in the bloom of life, are there interred. It was a happy thought. That spot, purpled with the blood of many a hero, and containing within its bosom the relics of the " departed brave", is now a consecrated cemetery. Here rest side by side the soldier and the priest of Erin. The one fought for Ireland's temporal interests, the other for her spiritual welfare..Books Dónal MacPolin and Peter Sobolewski, Blanchardstown, Castleknock and the Park, 2001, Cottage Publications James O'Driscoll, Cnucha: A history of Castleknock and district, 1977, privately issued Jim Lacey, A Candle in the Window, 1999 Marino Publications Tadhg O'Keeffe, Medieval Irish Buildings'', pp 230-231 2015 Four Courts Press References External links History of Castleknock Excerpt from book on Castleknock by Jim Lacey Fort of Cnucha and its Successors Category:Castles in Fingal Category:Castleknock Category:Ruins in the Republic of Ireland/* MIT License http://www.opensource.org/licenses/mit-license.php Author Tobias Koppers @sokra */ "use strict"; //文件路径做为moduleID class moduleIDbyFilePath { constructor(options) { } apply(compiler) { compiler.plugin("compilation", (compilation) => { compilation.plugin("module-ids", (modules) => { modules.forEach((module) => { if(module.id === null) { module.id = module.dependencies[0].module.rawRequest } }); }); }); } } module.exports = moduleIDbyFilePath; Blog Your network is growing. You're adding fiber cable like there's no tomorrow ... all to keep up with the non-stop demand for bandwidth. With no end in sight, you have to protect your network and ensure the quality of its signal.Licorice Bridge Mix Bridge mix is the candy version of the everything pizza, the all-the-way cheeseburger, and the ice cream sundae with the works. It's all the good stuff in one spot. This section showcases licorice bridge mix by Jelly Belly, one of the most celebrated American candy manufacturers. Jelly Belly bridge mixes feature all the best bits and pieces of licorice candy mixed up together, perfect for the candy dish and perfect for parties. It's also perfect for black licorice lovers, when you need to give something a little out of the ordinary. Choose from several varieties and sizes below and make somebody, or several somebodies, very, very happy!/* * (C) Copyright 2005 Embedded Alley Solutions, Inc. * Dan Malek <[email protected]> * Copied from STx GP3. * Updates for Silicon Tx GP3 SSA board. * * (C) Copyright 2002,2003 Motorola,Inc. * Xianghua Xiao <[email protected]> * * SPDX-License-Identifier: GPL-2.0+ */ /* mpc8560ads board configuration file */ /* please refer to doc/README.mpc85xx for more info */ /* make sure you change the MAC address and other network params first, * search for CONFIG_ETHADDR,CONFIG_SERVERIP,etc in this file */ #ifndef __CONFIG_H #define __CONFIG_H /* High Level Configuration Options */ #define CONFIG_BOOKE 1 /* BOOKE */ #define CONFIG_E500 1 /* BOOKE e500 family */ #define CONFIG_CPM2 1 /* has CPM2 */ #define CONFIG_STXSSA 1 /* Silicon Tx GPPP SSA board specific*/ #define CONFIG_MPC8560 1 #define CONFIG_SYS_TEXT_BASE 0xFFF80000 #define CONFIG_PCI /* PCI ethernet support */ #define CONFIG_PCI_INDIRECT_BRIDGE /* indirect PCI bridge support */ #define CONFIG_TSEC_ENET /* tsec ethernet support*/ #undef CONFIG_ETHER_ON_FCC /* cpm FCC ethernet support */ #define CONFIG_ENV_OVERWRITE #define CONFIG_FSL_LAW 1 /* Use common FSL init code */ /* sysclk for MPC85xx */ #define CONFIG_SYS_CLK_FREQ 33000000 /* most pci cards are 33Mhz */ /* Blinkin' LEDs for Robert :-) */ #define CONFIG_SHOW_ACTIVITY 1 /* * These can be toggled for performance analysis, otherwise use default. */ #define CONFIG_L2_CACHE /* toggle L2 cache */ #define CONFIG_BTB /* toggle branch predition */ #define CONFIG_BOARD_EARLY_INIT_F 1 /* Call board_pre_init */ #undef CONFIG_SYS_DRAM_TEST /* memory test, takes time */ #define CONFIG_SYS_MEMTEST_START 0x00200000 /* memtest region */ #define CONFIG_SYS_MEMTEST_END 0x00400000 /* Localbus connector. There are many options that can be * connected here, including sdram or lots of flash. * This address, however, is used to configure a 256M local bus * window that includes the Config latch below. */ #define CONFIG_SYS_LBC_OPTION_BASE 0xF0000000 /* Localbus Extension */ #define CONFIG_SYS_LBC_OPTION_SIZE 256 /* 256MB */ /* There are various flash options used, we configure for the largest, * which is 64Mbytes. The CFI works fine and will discover the proper * sizes. */ #ifdef CONFIG_STXSSA_4M #define CONFIG_SYS_FLASH_BASE 0xFFC00000 /* start of 4 MiB flash */ #else #define CONFIG_SYS_FLASH_BASE 0xFC000000 /* start of 64 MiB flash */ #endif #define CONFIG_SYS_BR0_PRELIM (CONFIG_SYS_FLASH_BASE | 0x1801) /* port size 32bit */ #define CONFIG_SYS_OR0_PRELIM (CONFIG_SYS_FLASH_BASE | 0x0FF7) #define CONFIG_SYS_FLASH_CFI 1 #define CONFIG_FLASH_CFI_DRIVER 1 #undef CONFIG_SYS_FLASH_USE_BUFFER_WRITE /* use buffered writes (20x faster) */ #define CONFIG_SYS_MAX_FLASH_SECT 256 /* max number of sectors on one chip */ #define CONFIG_SYS_MAX_FLASH_BANKS 1 /* max number of memory banks */ #define CONFIG_SYS_FLASH_BANKS_LIST { CONFIG_SYS_FLASH_BASE } #define CONFIG_SYS_FLASH_PROTECTION /* The configuration latch is Chip Select 1. * It's an 8-bit latch in the lower 8 bits of the word. */ #define CONFIG_SYS_LBC_CFGLATCH_BASE 0xFB000000 /* Base of config latch */ #define CONFIG_SYS_BR1_PRELIM 0xFB001801 /* 32-bit port */ #define CONFIG_SYS_OR1_PRELIM 0xFFFF

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(1+\log^{+}t\right)^{u},\varphi_{v}(t)=e^{t^{v}}-1.$$ Taking that into account, Lemma \[Lema2.2Pt\] gives $$\begin{split} & \int_{Q_{j}}\Phi_{\sum_{i\in\sigma}\frac{1}{s_{i}}}\left(\frac{|f(x)|}{\lambda}\left(b(x)-b_{Q_{j}}\right)_{\sigma'}\right)dx\\ & \leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx+\sum_{i\in\sigma}\int_{Q_{j}}\left(\exp\left(\left|b_{i}(x)-\left(b_{i}\right)_{Q_{j}}\right|^{s_{i}}\right)-1\right)dx\\ & \leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx+c\sum_{i\in\sigma}|Q_{j}|\|b_{i}\|_{expL^{s_{i}},Q_{j}}\\ & \leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx+c\sum_{i\in\sigma}|Q_{j}|\|b_{i}\|_{Osc_{expL^{s_{i}}}}\qquad\left[\|b_{i}\|_{Osc_{expL^{s_{i}}}}=1\right]\\ & \leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx+ck|Q_{j}|\\ & \leq c_k\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx. \end{split} \label{eq:1}$$ In the last step we used properties of the Calderón-Zygmund cubes. Plugging now that estimate, $$\begin{split} & c\sum_{i=1}^{k-1}\sum_{\sigma\in C_{i}^{k}}\sum_{j}\frac{1}{\varepsilon^{\#\sigma+1}}\inf_{z\in Q_{j}}M_{L(\log L)^{\sum_{i\in\sigma'}\frac{1}{s_{i}}+\varepsilon}}(w_{j})(z)\int_{Q_{j}}\Phi_{\sum_{i\in\sigma'}\frac{1}{s_{i}}}\left(\frac{|f(x)|}{\lambda}\left(b(x)-b_{Q_{j}}\right)_{\sigma}\right)dx\\ & \leq c_k\sum_{i=1}^{k-1}\sum_{\sigma\in C_{i}^{m}}\sum_{j}\frac{1}{\varepsilon^{\#\sigma+1}}\inf_{z\in Q_{j}}M_{L(\log L)^{\sum_{i\in\sigma'}\frac{1}{s_{i}}+\varepsilon}}(w_{j})(z)\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx\\ & \leq c_{k}\frac{1}{\varepsilon^{k}}\sum_{j}\inf_{z\in Q_{j}}M_{L(\log L)^{\frac{1}{s}+\varepsilon}}(w_{j})(z)\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx\\ & \leq c_{k}\frac{1}{\varepsilon^{k}}\sum_{j}\int_{Q_{j}}M_{L(\log L)^{\frac{1}{s}+\varepsilon}}(w_{j})(x)\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx\\ & \leq c_{k}\frac{1}{\varepsilon^{k}}\int_{\mathbb{R}^{n}}M_{L(\log L)^{\frac{1}{s}+\varepsilon}}(w_{j})(x)\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx \end{split}$$ For $L_{32}$ arguing in the same way we have that $$E_{2}\leq c_{k}\frac{1}{\varepsilon^{k}}\sum_{i=1}^{k-1}\sum_{\sigma\in C_{i}^{k}}\sum_{j}\inf_{z\in Q_{j}}M_{L(\log L)^{\frac{1}{s}+\varepsilon}}w_{j}(z)\int_{Q_{j}}\Phi_{\sum_{i\in\sigma'}\frac{1}{s_{i}}}\left(\frac{|f_{Q_{j}}|}{\lambda}\left(b(x)-b_{Q_{j}}\right)_{\sigma}\right)dx$$ The same computation used to obtain yields $$\int_{Q_{j}}\Phi_{\sum_{i\in\sigma'}\frac{1}{s_{i}}}\left(\frac{|f_{Q_{j}}|}{\lambda}\left(b(x)-b_{Q_{j}}\right)_{\sigma}\right)dx\leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f_{Q_{j}}|}{\lambda}\right)dx+ck|Q_{j}|.$$ Now we see that using Jensen’s inequality, $$\begin{split} & \int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f_{Q_{j}}|}{\lambda}\right)dx\leq|Q_{j}|\Phi_{\frac{1}{s}}\left(\frac{|f|_{Q_{j}}}{\lambda}\right)\\ \text{} & \leq|Q_{j}|\frac{1}{|Q_{j}|}\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx=\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx. \end{split}$$ Hence $$\int_{Q_{j}}\Phi_{\sum_{i\in\sigma'}\frac{1}{s_{i}}}\left(\frac{|f_{Q_{j}}|}{\lambda}\left(b(x)-b_{Q_{j}}\right)_{\sigma}\right)dx\leq\int_{Q_{j}}\Phi_{\frac{1}{s}}\left(\frac{|f(x)|}{\lambda}\right)dx+ck|Q_{j}|$$ and we finish the estimate arguing as we did for $L_{31}$. [^1]: The first author was supported by Grant MTM2014-53850-P and the second author was supported by Grant MTM2012-30748, Spanish Government alright so this friday me and my boyfriend are having a sleep over party lolHe is always sleeping over at my place but this friday i want to make it cute and fun. So here are the ideas i have so far.Watching cute barbie movies (im obsessed he hates it but will anyways)I want to make dill popcorn and other kind of tea partish food any ideas?Play bored games,Build forts.Ill probably make him shave his beard and give him a cute facial thing and paint his nails black . hes one of them metal heads lol.um so anyways give me ideas ladies? im like the luckeist girl in the world to have a bf whos 27 mind u that will do this with me <3 aw we have the same kinda thingmy bf has long hair tons of tatoos periicngs in a death metal band all that stuff. In his stocking he is ge ttin guitar picks. razors . socks. shampoo a brush cuz he donest have one for his long hair a spiked belt. chocolate and i think im gunna make him some felt monsters and spiders go to like spencers and get your bf some cute cheap belt buckles and shot glassesLinters For a long time, I’ve thought that code linting tools (linters) were a good idea in principle, but too annoying to use on a regular basis. Besides, I’ve always been pretty particular about my coding style, so I felt like I didn’t need a tool to help me do something I already do anyway. I have used SmallLint (a.k.a., the Code Critic) to good effect in my Visualworks Smalltalk projects, even going so far as to write some additional rules and integrating the tool into my automated builds. But even there, some of the rules would produce false positives that I didn’t think needed to change. As our team started working with ES6, React, and Redux, we decided to adopt linters to help us out. I was a bit reluctant, but we all felt like it would be good to have some “training wheels” as we were learning the new tools. I privately felt like we’d probably out-grow the need for linting after a month or two. I have to come right out and say it: I was totally wrong. We adopted ESLint for JavaScript and sass-lint for CSS. We set up initial configurations for both tools that matched the way we wanted to write our code, and we’

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des extensions de concept est un critère nécessaire et suffisant pour qu'existe entre concepts la relation qui correspond à l'identité pour les objets. J'ajoute que j'emploie le terme « identique », sans autre précision, au sens de « pas différent de », « coïncidant avec », « le même que ». Les logiciens psychologiques ne peuvent pas mieux comprendre l'identité que la définition. Cette relation d'identité ne peut que leur poser une énigme ; si les mots désignaient constamment des représentations, on ne pourrait jamais dire « _A_ est la même chose que _B_ » car il faudrait déjà distinguer _A_ de _B_ , et on aurait des représentations différentes. Cependant, je partage avec l'auteur l'idée que l'explication proposée par Leibniz : _eadem sont quorum unum potest substitui alteri salva veritate_ ne mérite pas d'être appelée définition, mais pour d'autres raisons que lui. On pourrait dire que la proposition de Leibniz est un principe qui exprime l'essence de la relation d'identité ; en tant que tel, son importance est capitale. Quant à l'explication proposée par l'auteur (p. 108), « on dira simplement que deux contenus quelconques sont identiques s'il y a identité des caractères qui constituent le foyer de l'intérêt », je la trouve insipide. Venons-en aux détails. Selon l'auteur, la donnée d'un nombre se rapporte à la totalité (ensemble, multiplicité) des objets comptés (p. 185). Une totalité de ce genre est parfaitement exprimée au moyen de la conjonction « et ». On devrait s'attendre à ce que l'attribution d'un nombre soit toujours de la forme : « _A_ et _B_ et _C_ et... _Q_ sont _n_ », ou puisse être ramenée à cette forme. Mais que peut bien apporter la proposition « Berlin et Dresde et Munich sont trois » ou, ce qui doit revenir au même, « Berlin et Dresde et Munich sont quelque chose et quelque chose et quelque chose » ? Qui se donnerait la peine de poser une question pour obtenir une telle réponse ? En aucun cas, on ne saurait y voir l'affirmation que Berlin est différent de Dresde, Dresde différent de Munich, et Munich de Berlin ; et en fait l'énoncé, au moins sous sa deuxième forme, ne dit pas que Berlin et Dresde sont différents, ni qu'ils sont identiques. Il est remarquable que la langue quotidienne ne donne aucun exemple d'un énoncé de cette forme quand elle attribue un nombre. Et si jamais on rencontre cette forme, elle n'a pas le sens d'une attribution de nombre. Je n'ai trouvé que deux emplois de cette forme : en premier lieu, avec le terme « deux » pour exprimer la diversité : « Des bettes et des raves cela fait deux » ; en second lieu, avec le terme numérique « un » pour exprimer l'identité — « Moi et mon Père sommes un ». Cet exemple est particulièrement gênant car, d'après notre auteur, on devrait avoir « sont quelque chose et quelque chose » ou « sont deux ». En réalité on ne demande pas « combien font César et Pompée et Londres et Edimbourg ? » ni « combien font la Grande-Bretagne et l'Irlande ? » — et je serais curieux de la réponse de l'auteur. Mais on demande, par exemple, « Combien Mars a-t-il de satellites ? » ou « Quel est le nombre des satellites de Mars ? » et la réponse : « Le nombre des satellites de Mars est deux » donne une information qui méritait la question. On remarquera que la question et la réponse comportent un terme conceptuel ou une désignation conceptuelle complexe, au lieu du « et » requis selon notre auteur. Comment se tire-t-il de la difficulté ? En disant que le nombre appartient à l'extension de concept, c'est-à-dire à la totalité. « Mais on dira de manière seulement indirecte que le concept a cette propriété, à savoir que le nombre appartient à son extension » (p. 189). C'est accorder tout ce que j'affirme : l'attribution d'un nombre énonce quelque chose d'un concept. Et je ne disputerai pas si l'énoncé porte directement sur le concept et indirectement sur l'extension, ou directement sur l'extension et indirectement sur le concept ; car l'un va avec l'autre. Il est certain en tout cas que, dans une proposition attribuant un nombre, ne sont désignés directement ni une totalité ni une extension de concept mais un concept. Si l'auteur employait le terme « extension de concept » au sens où je l'entends, nous différerions bien peu sur le sens d'une proposition énonçant un nombre. Tel n'est pas le cas, et l'extension de concept n'est pas une totalité au sens de l'auteur. Un concept sous lequel tombe un seul objet a une extension aussi déterminée qu'un concept sous lequel ne tombe aucun objet ou sous lequel tombent une infinité d'objets. Or, dans ces derniers cas, il n'y a pas, selon M. Husserl, de totalité. Le sens des mots « extension du concept satellite de Mars » est autre que celui des mots « Deimos et Phoebus », et la proposition « le nombre de Deimos et Phoebus est deux », si jamais elle contient une pensée, contient une pensée à coup sûr différente de la pensée exprimée dans « le nombre des satellites de Mars est deux ». Du fait que personne n'emploie une proposition de la première forme pour attribuer un nombre, le sens d'une proposition qui attribue un nombre a échappé à notre auteur. Examinons de plus près la manière dont prend naissance une totalité (p. 77 et s.). J'avoue que je ne suis pas parvenu à construire une totalité en suivant les directives de l'auteur. Dans la liaison collective, les contenus doivent seulement être pensés ou représentés ensemble, sans que soit pensée ou représentée aucune liaison ou relation entre ces contenus (p. 79). Je n'y arrive pas. Je ne peux pas me représenter le rouge, la lune, et Napoléon sans les imaginer dans un certain lieu, par exemple le rouge d'un village en flammes devant lequel se dresse la silhouette de Napoléon dans la lumière du clair de lune. Je me représente comme un tout ce qui m'est simultanément présent, et je ne peux pas faire abstraction du lien sans perdre le tout. Je soupçonne qu'il n'y a pas dans mon âme ce que l'auteur appelle « totalité », « ensemble », « multiplicité », une représentation des parties dont l'unité n'est pas représentée en même temps que les parties, bien qu'elle soit donnée en même temps. Aussi n'y a-t-il pas lieu de s'étonner que l'auteur dise un peu plus loin (p. 242), à propos de l'ensemble, qu'il possède un moment figurai qui le caractérise comme un tout, une articulation. Il parle (p. 235) d'une suite, d'un essaim, d'une chaîne, d'un tas, comme de types particuliers d'ensembles. Il n'y aurait donc aucune unité sensible dans la représentation d'un essaim ? Ou bien cette unité est-elle donnée à côté du lien collectif ? En ce cas, elle n'appartient pas à la totalité, et le moment figurai ne saurait servir à la distinction des types d'ensembles. Comment l'auteur a-t-il pu venir à cette opinion ? Vraisemblablement parce qu'il attribue aux mots et suites de mots certaines représentations déterminées à titre de dénotation. En ce cas, à la suite des mots « rouge et la l

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was adopted from the Covenant.[1] The Jiralhanae within the Covenant were zealous beings, known for their willingness to cling to ancient, bloody traditions and many among the Jiralhanae, notably Tartarus, held an unwavering belief in the words of the Prophets and in the promise of the Great Journey, however not all Jiralhanae were fanatical adherents to the Covenant religion and many Jiralhanae had soon abandoned the Covenant religion upon the collapse of the Covenant.[2] Their homeworld of Doisac is war-torn, and Jiralhanae are known for their particular joy in vicious activities, complimented by regimented discipline. As part of the Covenant, Jiralhanae were required as a prerequisite to convert to the Prophets' religion of worshipping the Forerunners. Previously, their culture revolved around the worship of totems and idols[1] and their religion was based on the lunar cycles of Doisac's three moons,[2] but they made swift converts due to their search for theological meaning.[14] The Jiralhanae within the Covenant were one of the most fanatical adherents to the Prophets' faith, although they seemed to hold little concept of sanctity, evidenced by Tartarus' improper handling of the "Oracle" 343 Guilty Spark.[17][38] Following the dissolution of the Covenant most Jiralhanae abandoned their belief in the Great Journey.[2] The Jiralhanae fighting style is forceful, utilitarian, and pragmatic.[6] They prefer using weapons from their homeworld rather than the Covenant's standard plasma-based firearms. Jiralhanae weapons are notable for being extremely dangerous, somewhat primitive and brutal, and always featuring a blade attachment such as the Type-25 Spiker, Type-52 Mauler, Type-25 Brute Shot, and the Type-2 gravity hammer. These weapons show their barbaric nature, for example, the fact that all of the weapons are named after ways of injury or causing bodily harm to another being. The many spikes and serrated edges that adorn their race's weapons, vehicles and armor further support this. However, they do have their own type of plasma rifle. The Sangheili abhorred the Jiralhanae weapons due to their primitive nature, but allowed them to be serviced in low numbers.[39] Unlike the Sangheili, the Jiralhanae have no qualms about using human weaponry. Some were seen using human shotguns during the Human-Covenant War.[40] The Jiralhanae are disdainful of every other species except the San'Shyuum.[14] In general, Jiralhanae have a pronounced dislike of the Sangheili because the former believe they are better protectors of the Prophets than the Sangheili, as well as the Sangheili's mistreatment of the species during the Covenant's reign.[41] The High Prophet of Truth took advantage of this to ignite the Great Schism during the Battle of Installation 05.[40] However, some Jiralhanae have surrendered and are willing to labor under the Sangheili after the end of the war.[42] Jiralhanae interpret direct eye contact as a challenge. They have been known to brutally beat to death humans who have boldly dared to stare at them.[43] Jiralhanae society is dominated by a fierce pack culture and a focus on lineage. Familial bonds tie each member to the other, forcing them into states of berserker rage and desperate mourning for their fallen pack mates should one die in battle. Jiralhanae society is an authoritarian dictatorship controlled by the strongest male;[2] dominance is established by the social, martial, and sexual success of the patriarch. Patricide is an common side effect of the patriarchy due to the ambition seeded within many Jiralhanae to rise to the top of a hierarchy.[44] Female Jiralhanae generally serve as mothers and caretakers.[2] No females have been observed in military roles.[45] A Jiralhanae's blood relation to another Jiralhanae did not offer subordinates immunity from discipline.[46] Each pack is led by a prominent chieftain who wields a ceremonial gravity hammer, passed from one leader to another upon his death, to denote his status. A Jiralhanae becomes a pack chieftain by challenging the current chieftain to a mortal duel; the victor claims the title after executing the other. The chieftain rules his pack like his own empire. An individual's rank is measured by success on and off the battlefield, unlike the more martial Sangheili.[1] Interactions among the Jiralhanae are dominated by personal status, which they display through decoration and ornate armor.[45] Jiralhanae exhibit a variety of grooming styles to denote their status and pack affiliation. Jiralhanae typically are either clean shaven or sport mohawks, goatees or beards. However, some Jiralhanae packs do away with shaving altogether. Some Jiralhanae packs also adorn themselves with tattoos over their entire bodies.[47] Due to their combative and aggressive nature, the Jiralhanae lack a single cohesive government. Instead, Jiralhanae society can be viewed as an extension of their pack structure, but with a number of different levels: Skeins are the largest social division of Jiralhanae, "meta-clans" formed out of multiple packs sharing a similar philosophy and interests. A given skein is dominated by the most powerful clan within. During the First Immolation, most Jiralhanae fell into one of two dominant skeins: the Rh'tol and the Vheiloth. The two skeins display stark cultural and political differences: the Rh'tol are considered more primitive and aggressive, while the Vheiloth are generally more sophisticated and open to new ideas.[2] Alpha Tribes[48] and master-packs are seemingly dominant clans or groupings consisting of multiple packs. Prior to contact with the Covenant, rival master-packs reduced Jiralhanae society to a pre-industrial level through warfare.[12] Packs range in size and importance, with less important packs made up largely of Unggoy or Kig-Yar forces and led by a low-ranked Jiralhanae, and more important packs led by War Chieftains and comprised of more experienced veteran Jiralhanae bodyguards.[49] Whereas the Sangheili used to command the Covenant's military and serve as the personal protectors of the San'Shyuum, the Jiralhanae primarily served as the Covenant's shock troops and secret police. This changed with the outbreak of the Great Schism, when the Jiralhanae supplanted the Sangheili in all areas of the Covenant military.[9][36] The Jiralhanae treated all the species under their command as expendable cannon fodder. If a subordinate failed to complete their task in any aspect, the leading Jiralhanae would enact a swift punishment, generally execution.[45] Eager to prove themselves superior over the Sangheili, the Jiralhanae often acted with no respect for the lives of civilians or other races.[6] Sangheili and Jiralhanae fleets were largely segregated, but this was not always the case.[51] Believing that the Jiralhanae posed a threat to both the Sangheili and the Covenant, a union of Sangheili commanders convinced the Covenant High Council to impose restrictions on the technology used by the Jiralhanae. The number of Jiralhanae shipmasters was limited and the weaponry on Jiralhanae ships was mostly disabled.[6][16] Jiralhanae units are typically deployed in packs led by one or more chieftains or captains. Apart from their role as shock troopers, they often fill a similar combat role to the Sangheili, as both typically command groups of lesser infantry. However, Jiralhanae generally were not equipped with energy shields (except for captains and chieftains) until the outbreak of the Great Schism, when power armor saw widespread use among Jiralhanae forces. According to Arbiter Thel 'Vadam, Unggoy serving under the Jiralhanae during the Great Schism exhibited newfound courage due to fear of their masters.[52] The native Jiralhanae language is animalistic, incorporating a wide range of sounds from growls and barks to howls and roars,[53] though Jiralhanae also express emotions through scents and musks. Young Jiralhanae have difficulty controlling the release of these scents, but learn how to moderate them as they grow older.[37] A communal howl is often made by the packchieftain as a sign of celebration, and failure to participate in the howl is a serious sign of disrespect to the Chieftain's authority.[54] Most known Jiralhanae have Latin-sounding names, such as Tartarus and Bracktanus. The "-us" at the end of their name is an honorific denoting maturity or

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up at Princeton. Amherst has one that’s bigger than this and I think Temple University has one that’s bigger than these. We had these all cabled up so you could mow underneath this and all, and that same storm that did all the damage just didn’t break the cables but it took the screw eyes and straightened them right out flat and all these limbs came down on the ground. We lifted them up this high just to get some blocks underneath. The biggest problem we’ve had with it is right in the dead center. We’re always losing something out of the center, even the one that’s across the way over there we lost. Any of these clump things, you’re going to lose something in the middle, whether they get crowded out or what, I don’t know. The same thing happened to us on that one over there. PP: We’re sitting on the bench under the Japanese maple. Is this an original bench location? DS: No, this bench is one – there was a bench here, yes. This is not one of the originals. PP: Was the bench like this? DS: Yes. PP: A different design? DS: No, it was like this. PP: So, they did buy some benches that weren’t custom made? DS: Oh yes. Some of them are knockouts, a lot of those around the swimming pool. I bought two batches from Country Casual since then. I bought five here a couple years ago because they were all rotting out. But you notice, most of our benches, we have them up on a brick or on a flagstone, something to get the legs off the ground. That seems to be where they rot. PP: We see a bench over by the Gothic Garden, is that an original bench location? DS: Yes, but there was a Gothic Garden there, that was a complete circle at one time over there. PP: The circle in front of that bench? DS: Yes, you had to walk in right on this upper end here, there’s an opening, that circle came around this way and all that box was terrible. It looked like it had been buried. I’d tell you it was buried, but I don’t want it on that, shut that off. PP: The Gothic Garden was a circular boxwood area about fifteen feet across and there’s a little bench inside and there was only one way in. DS: Yes. PP: And someone piled dirt up around them and caused them to die on one side. DS: That’s what killed them as far as I’m concerned. Also this was landscaped at the time when little secret gardens were the thing for most of the people. This is kind of a little – you had to go in through the hedge to get in there. PP: Interesting idea. We see a stone tub up there towards the Rose Garden. Tell me the history of that, where it was, what it is. DS: I don’t know what, we just always called it the bathtub but originally I think it was on the Bowling Green, on the west end of the Bowling Green. I’ve seen pictures of it there, but it sat right here ever since I’ve been here, sat right over on that spot. PP: Has it ever held water? DS: Not that I know of. PP: Is it made to hold water? DS: There’s a drain in it. A lot of people have had their pictures taken sitting in there like they were taking a bath. PP: Have you ever rebuilt this walk here, this brick walk? DS: About once a week we’re replacing brick in here and you’ll be doing it for the next fifty years, as long as you’ve got tree roots. You can come in here today and replace every single one of these bricks and come back next week and replace some more of them, especially right in this area right through here. PP: Makes it kind of tough for the wheelchairs, doesn’t it? DS: It does, but what’s the worse thing on the brick walks here, they’re not in a concrete base or anything but they’re just laying on the ground, they’re in sand, and in the wintertime they freeze and thaw. [end of tape 4] DS: This is Crab Hill and the only thing that has changed – we only have one more of the big old crabs still here. We had four and two of them have died, and we lost another one right in this spot from a hurricane. They went down and cleaned out a bunch of little ones we had. This one here that we’re talking about now taking down, it’s about ready to go and that one down there are the two oldest. And there’s a couple over back on, not this group in here, but that over in there, they were in here then. The yucca was here, the daylily beds and the iris beds were here, except for those few that are over near the swimming pool, and that’s some of the new hybrids we put in to give more color through the summertime. The [inaudible] are way down at the bottom here on the left hand side, that was something that was put in here many years ago. Mr. Kearney put that in, in fact, in the files there’s a picture of Matt and two or three of the crew bringing that down the hill on a platform and putting it in. The fringe tree, I bought about five of those and we stuck them in various parts of the garden and that one has been knocked down to the ground twice with the cold weather, for some reason, but now it’s come flourishing right back. And also right beside it there’s a little flowering almond, that was in here when I came here and that thing never gets over three foot high and that’s the only one we’ve got on the place and it blooms its head off. It’s straight down beyond the yucca. It’s just a little tiny thing, that blooms its head off. This is a Chinese or Japanese lilac and it blooms real late in the last of the spring shrubs bloom. It doesn’t have a very good fragrance but it’s something that’s been here for years and years and years. The magnolia behind it was in there, the [inaudible], the Canadian cherry behind that, that was in here when I came and all of that planting that’s over in the valley. The forsythia over in there, those were all in here. That tulip poplar in here, which is fifteen–eighteen inches across now, that was a small tree that was put in here just before I came. And the big cherry that’s in there, that was already there. There haven’t been that many changes. We have added some crabs when the old ones went by, but we still kept the crabapples. PP: Have the beds ever been dug or divided? DS: Now we’ve cleaned them out and made them smaller, some of the bigger clumps. In fact, we tightened them and split them up and moved them around, there was just too much of it here anymore. Those iris beds, they were already here. PP: What about the yucca? DS: The yucca was in there. The day I came here that thing was in here then and it’s been here for years. And the daylilies around us, that bed has not changed in here at all. PP: What about the bed of the winter flowering jasmine in the ivy down by – DS: That winter flowering jasmine, that was put in there. When they redid the North Vista walls and redid that end down there where the railing is, after they got that – in fact when I came here they were just finishing the stone carving, they hadn’t even put the walls up – and the jasmine had just gone in there like a year or two before that. And from what Mr. Kearney told me, he said that was put in temporarily and they never changed it so it’s worked out fairly well. It’s a nice show in the middle of the winter, real nice, and we’ve let the ivy come underneath it to give it a green background. But when it is in bloom the jasmine will lose its leaf and it blooms its best on the bare step and with that green background it’s much better. PP: Are these any particular variety of crabapple that you use? DS: I don’t even know the name of this old one. PP: Do you know the names of the younger ones? DS: There’s some red jades in there and the zumi down on that bottom side and I think there’s some coronaria in here and there’s a couple of sargents in here. PP: Are these daylilies, these are the orange lilies and the lemon lilies, or? DS: Yes, all of these are the old orange ones, but that group up in there, there’s a double yellow, there’s some single yellow hybrids up there, and this is that red that has the yellow streak in it, just for variety. I got

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, neither official was aware of the complete circumstances surrounding the defendant wood, namely the quantity of wood involved. Regardless, the Court declines to find that a lack of unanimity on the application of the statutory provisions based on incomplete facts is in any manner dispositive of this issue. The Court is inclined however to agree with the Government's position that "it cannot be seriously argued that the common understanding of what would be involved in the movement's of ones' belongings from one household to another would normally include enough building material to replace the floors and doors in an entire house with over 2,000 square feet of living space." (Govt. Opp. Cl. Mot. Summ. J. 35.) It is virtually impossible to believe that a person of ordinary intelligence and understanding would believe that this is typically or appropriately designated as a normal part of a household move. Claimants' weak arguments taken in conjunction with the level of deference and flexibility accorded statutes imposing civil penalties lead the Court to conclude that the statutes indicated by Claimants are not void for vagueness. Therefore, the Court denies Claimants Motion for Summary Judgment based on due process claims grounded in allegations of unconstitutional vagueness because Claimants have made an inadequate showing that someone of ordinary intelligence would be unable to ascertain from the relevant statutory provisions that this quantity of building materials would not qualify as household effects so as to be exempt from CITES's Certificate of Origin requirements. 5. Valuation The Court denies Claimants' Motion for Summary Judgment based on improper valuation because regardless of the value of the property and whether the Government initiated the forfeiture action as an administrative or a judicial forfeiture action, Claimants' decision to contest the forfeiture required the matter to proceed judicially, and therefore the procedural posture of this case and the ultimate outcome would have been the same. Following seizure, the retail value of the property must be ascertained. 7 C.F.R. § 356.2. If the property is valued at less than $10,000 the property must be forfeited administratively, and if it is valued at more than $10,000 it must be referred to the United States Attorney's Office for the institution of forfeiture proceedings in the appropriate United States District Court. 7 C.F.R. § 356.3; 7 C.F.R. § 356.4. If after proper notification of the commencement of an administrative forfeiture, a claim is filed, the action must be converted to a contested judicial forfeiture. 19 U.S.C. § 1608. Claimant devotes significant energy to contesting the manner in which the appraisal of the defendant wood was conducted and finding fault in the disparity in value produced by multiple appraisals. After all of this, Claimants conclude that the "correct" valuation was $6,400, and that therefore this action should have been commenced administratively and because it was not, they are entitled to summary judgment. The Court declines to entertain this dispute over the value of the wood because, if nothing else is clearly ascertainable from the voluminous record in this matter, it is certain that regardless of whether this forfeiture was commenced administratively or judicially, the Thompsons would have filed a claim contesting the forfeiture of their property. The matter would have been automatically transferred to this Court's jurisdiction and would have subsequently proceeded in the exact same manner that it has. 19 U.S.C. § 1608. The Court therefore denies Claimants' Motion for Summary Judgment based on improper valuation of the defendant wood because even if the valuation had been determined as they preferred, their decision to contest the forfeiture would have resulted in the same procedural posture in this matter. 6. Eighth Amendment: Excessive Penalty The Court denies Claimants' Motion for Summary Judgment based on allegations that the forfeiture of the defendant wood constitutes an excessive penalty because Claimants have failed to satisfy their burden of demonstrating that the forfeiture was grossly disproportionate by a preponderance of the evidence. 18 U.S.C. § 983(g) codifies the constitutional proscription against excessive fines and permits claimants in civil forfeiture actions to challenge such forfeitures as constitutionally excessive. In recent years, prior to the promulgation of § 983, the Supreme Court considered the application of the Excessive Fines Clause of the Eighth Amendment to forfeiture actions on two occasionsfirst in 1983 in Austin v. United States and again in United States v. Bajakajian, in 1998. Austin v. United States, 509 U.S. 602, 113 S.Ct. 2801, 125 L.Ed.2d 488 (1993); United States v. Bajakajian, 524 U.S. 321, 118 S.Ct. 2028, 141 L.Ed.2d 314 (1998). Following the issuance of those two opinions, the Fourth Circuit considered the implications of these two cases when read in conjunction with one another in United States v. Ahmad, 213 F.3d 805 (4th Cir.2000). In Austin, the Court "held that the limitations imposed by the Excessive Fines Clause of the Eighth Amendment apply to in rem civil forfeiture proceedings if the forfeiture, at least `in part' constitutes punishment." See Ahmad, 213 F.3d at 812 (summarizing Austin). In distinguishing between punitive and remedial forfeitures, the Austin Court concluded that "forfeiture generally and statutory in rem forfeiture in particular historically have been understood, at least in part, as punishment." Austin, 509 U.S. at 618, 113 S.Ct. 2801. The Court went on to indicate that forfeitures involving the seizures of instrumentalities were more appropriately designated as remedial. Id. at 619, 113 S.Ct. 2801. The Court's analysis stopped short, however, of setting out a test for determining whether a forfeiture is in fact constitutionally excessive. Id. at 622, 113 S.Ct. 2801. Five years later, this issue returned before the Court in Bajakajian, and this time it chose to articulate a test for determining whether a punitive forfeiture violated the Excessive Fines Clause. The Court in Bajakajian, first created an unclear distinction between traditional and modern civil in rem forfeitures, indicating that "[t]raditional in rem forfeitures were... not considered punishment against the individual for an offense" and that "[b]ecause they were viewed as nonpunitive, such forfeitures traditionally were considered to occupy a place outside the domain of the Excessive Fines Clause." Bajakajian, 524 U.S. at 331, 118 S.Ct. 2028. These forfeitures were to be distinguished from more modern forfeiture statutes that have "blurred the traditional distinction between civil in rem and criminal in personam forfeiture." Id. at n. 6.[8] However, the Court gave very little guidance on categorizing forfeitures as traditional versus modern. In Bajakajian the property that was the subject of the forfeiture was money that Bajakajian failed to report upon exportation. The Government urged the Court to designate the cash a instrumentality on the basis that it not only facilitated the violation of the law, but was "the very sine qua non of the crime." Id. at 333, 118 S.Ct. 2028. The Court declined to extend the definition of instrumentality as such, noting that "the currency in question is not an instrumentality in any event.... [It] is merely the subject of the crime of failure to report." Id. at 334 n. 9, 118 S.Ct. 2028. The Fourth Circuit in Ahmad would later read Bajakajian as setting forth the following factors for the next step in the Court's analysisassessing the gravity of the offense: "the nature and extent of the criminal activity, other related illegal activities ..., the extent of the harm caused by the offense, and the maximum penalties a court could have imposed for the offense." Ahmad, 213 F.3d at 816. Ahmad was decided on May 25, 2000. CAFRA became law on August 23, 2000, and included the provisions of 18 U.S.C. § 983(g): (g) Proportionality (1) The claimant under subsection (a)(4) may petition the court to determine whether the forfeiture was constitutionally excessive (2) In making the determination, the court shall compare the forfeiture to the gravity of the offense giving rise to the forfeiture. (3) The claimant shall have the burden of establishing that the forfeiture is grossly disproportional by a preponderance of the evidence at a hearing conducted by the court without a jury. (4) If the court finds that the forfeiture is grossly disproportional to the offense it shall reduce or eliminate the forfeiture as necessary to avoid a violation of the Excessive Fines Clause of the Eighth Amendment. 18 U.S.C. § 983(g). Few federal circuit courts have had the occasion to evaluate Excessive Fines Clause challenges to civil forfeitures under § 983(g).[9] For this reason it is reasonable to look at what has been written regarding reconciling the aforementioned Supreme Court precedent with recent statutory modifications. Congress essentially codified the Bajakajian decision in 18 U.S.C. § 983(g), enacted as part of the CAFRA. Although Bajakajian is a criminal forfeiture case, the codification applies only to civil forfeiture cases. It modifies or goes beyond what the Supreme Court held in several respects. First, it places the burden of establishing gross disproportionality on the claimant, by a preponderance of the evidence. Second, it makes clear that the excessiveness issue is to be decided by the court without a jury. Most importantly, it provides an excessiveness defense in any type of civil forfeiture; unlike Bajakajian, it does not distinguish between "traditional" civil forfeitures and "modern" civil

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approach minimizes toxicities and ensures that chemotherapy is administered when its effect can be assessed using measurable disease. Improving outcome in high-grade gliomas requires an emphasis on discovering novel therapies and improving the design of adjuvant trials.For Against Liberty City still little more than a backdrop, story a little too led by the hand There’s absolutely little doubt whatsoever that Grand Theft Auto IV is one of the very best gaming experiences currently available. The tale of Niko Bellic, and his drop into the murky underworld of Liberty City, was enough all on it’s own to be an absolute must buy. But a wide open world and some fantastic online gaming helped urge us to award the game a full 10 score when we reviewed the original. In fact, head over to read our initial review to get caught up on the basics before carrying on. This PC release of Rockstar’s latest epic only reminds of just why all these high scores and awards have been lavished on this multi-million selling title. But, it also gives the opportunity to revisit a game that unfortunately did suffer from a handful of flaws that could just prevent it from being fondly remembered in years to come. Firstly, Niko’s story may be fairly lengthy, packed with detail, and an enjoyable ride. But, there’s little doubt that the freedom we’d all hoped for simply isn’t there. Missions are tightly structured, with anything more than minute deviation from the set path only helping in forcing you to fail this latest task. And the lack of mid-mission checkpoints is still horrifically frustrating. Similarly, the land of Liberty City wasn’t fleshed out as fully as we’d craved. While a stunning backdrop to enjoy as you progress through the games huge storyline, or as you simply cause merry hell for the cities unfortunate inhabitants, there simply wasn’t enough to do. Instead of feeling as if you’re witnessing a huge city just waiting to be explored and tinkered with, GTA IV’s Liberty City is little more than a pretty backdrop. Flaws to the title aside – all of which are still firmly included here as this isn’t much more than a port of the console originals – this is still the Grand Theft Auto IV that millions have loved and enjoyed. And now it’s available for PC owners to see just why all those console owners fell in love. For PC owners, there’s the usual slight nudge upwards in terms of graphical splendour if you’re packing a particularly healthy gaming rig. Ignore the auto settings that the game detects for you as they will inevitably be way too optimistic and have a half hour tinker to get everything running smooth as silk. For us even the perfect settings still seemed to stutter when the action really starts to heat up. Irritating, but even so, Liberty City will still astound as it is such an incredibly beautiful game world. The biggest addition for YouTube fans is the replay editor. Prod your F2 key and the last 30 seconds of GTA action will be stored on your hard drive, just waiting to be edited, set to some kind of horrific rawk soundtrack, and uploaded and pimped around gaming forums the world over. It certainly gives much more scope to the ability to go crazy wild in Liberty City when you can create some stunning clips to show off to your gaming chums. That’s not all. You know that huge mass of music stored on your hard drive? Well you now have your own music station where you can play a selection of your favourites. It might not sound an astounding feature, particularly when the variety of stations, music and banter on offer in game is quite impressive, but it definitely helps the excitement levels when a classic tune drops as you’re cruising the highways. The fantastic multiplayer is much the same as the console versions, with one very noticeable difference. Instead of up to 16 spots for online gamers, that number has now doubled to 32, allowing you the opportunity for much larger, more hectic, and overall far more exciting multiplayer experiences. A fantastic inclusion. Verdict It’s the same old GTA IV, with a few additions tossed into the mix. With a patch now (almost) obliterating the early bugs that stopped a large number of users even initialising the game, this one is absolutely essential for PC gamers. Time has helped show off a few flaws in proceedings – hence the drop to a score of 9 – but this is still worthy of all those awards and high scores it’s been showered with. To echo our original review, buy it, play it, experience it.[Sensitivity of bacteria causing urinary tract infections towards terizidon (author's transl)]. In agar diffusion tests 2603 bacterial strains of species known to cause urinary tract infections were tested routinely in regard to their sensitivity towards Terizidon, a derivative of cycloserine. In order to relate the results which were obtained in terms of the diameter of the inhibiton zone, to the minimal inhibitory concentrations (MIC), 304 of these strains were tested additionally in agar dilution tests. The MICs of the other strains were estimated from the results of these tests. Since it is known that after the oral administration of 500 mg Terizidon the urine contains, on average, more than 128 mug/ml Terizidon for 12 hours and longer, it may be concluded from the results of this investigation that 75% of the strains of E. coli and Citrobacter, 45% of enterobacter, 40% of Proteus mirabilis and enterococci, 35% of the indole-positive Proteus strains and 30% of Pseudomonas aeruginosa would have been successfully attacked by Terizidon in the case or urinary tract infections. By contrast, Klebsiella must be reagarded as being completely resistant to this antibiotic. It follows that the administration of Terizidon is mainly indicated in the treatment of acute urinary tract infections with E. coli as the predominant causative agent.List of Jay Jay the Jet Plane episodes This is a list of episodes of the television series Jay Jay the Jet Plane. Episode consistency depends on the order: one episode says that the character Snuffy has not flown further away from Tarrytown than Lightning Bug Lake, but other episodes show him flying much further; in "Catch the Buzz" Snuffy still has not got rid of his original shyness, but in many other episodes he shows no sign of shyness. Series overview {| class="wikitable" |- ! style="padding: 0px 8px" rowspan="2" colspan="2" | Season ! style="padding: 0px 8px" rowspan="2" | Episodes ! style="padding: 0px 80px" colspan="2" | Originally aired (U.S. dates) ! style="padding: 0px 8px" rowspan="2" | Original network |- ! First aired ! Last aired |- | style="background-color: #f03; color: #100; text-align: center; top" | | style="text-align: center; top" | [[List of Jay Jay the Jet Plane episodes#Season 1 (1998)|1]] | style="text-align: center; top" | 12 | style="text-align: center; top" | | style="text-align: center; top" | | style="text-align: center; top" rowspan="2" | TLC |- | style="background-color: #90b; color: #100; text-align: center; top" | | style="text-align: center; top" | [[List of Jay Jay the Jet Plane episodes#Season 2 (1999–2000)|2]] | style="text-align: center; top" | 14 | style="text-align: center; top" | | style="text-align: center; top" | |- | style="background-color: #FFD200; color: #100; text-align: center; top" | | style="text-align: center; top" | [[List of Jay Jay the Jet Plane episodes#Season 3 (2001)|3]] | style="text-align: center; top" | 14 | style="text-align: center; top" | | style="text-align: center; top" | | style="text-align: center; top" rowspan="2" | PBS Kids |- | style="background-color: #ffffff; color: #100; text-align: center; top" | | style="text-align: center; top" | [[List of Jay Jay the Jet Plane episodes#Jay Jay's Mysteries series|4]] | style="text-align: center; top" | 10 | style="text-align: center; top" | | style="text-align: center; top" | |} Pilot series Television series Main series Season 1 (1998) Season 2 (1999–2000) Season 3 (2001) Jay Jay's Mysteries series The Mystery of Plants The Mystery of Weather The Mystery of Size and Shape The Mystery of Flight The Mystery of the Five Senses The Mystery of Water The Mystery of Bugs The Mystery of Time The Mystery of Stars and Planets The Mystery of Dinosaurs Jay Jay The Jet Plane episodes list ofMr. Perry introduced the following

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and 402 of the Pharmacy Act place limitations on pharmacies, but they do not specify which pharmacies. A reading of these statutes to hold that the Puerto Rico Secretary of Health may inspect out-of-state pharmacies or that a pharmacist in another state must reside in the town where he is practicing or that an out-of-state pharmacist may only be absent from his pharmacy during the times set forth in section 402 would read these sections to be an unconstitutional attempt to regulate commerce outside the borders of Puerto Rico. See Healy, 491 U.S. at 336, 109 S.Ct. at 2499; Brown-Forman Distillers, 476 U.S. at 582-85, 106 S.Ct. at 2086-87; Edgar, 457 U.S. at 641-43, 102 S.Ct. at 2640-41; K-S Pharmacies, 962 F.2d at 730-31. The Puerto Rico Supreme Court has recognized that a state may exercise jurisdiction only over persons and things located within its territory. Pueblo v. Contreras, 95 J.T.S. 161, 402 n. 1 (1995); Toro Ruiz v. Junta de Libertad Bajo Palabra, 93 J.T.S. 120, 11033 n. 2 (1993); Medina v. Tribunal Superior, 104 P.R.Dec. 346, 348, 4 Official Translations 483, 486 (1975). Therefore, this Court concludes that the Puerto Rico Supreme Court would read the provision in section 396 on inspections by the Secretary of Health, in section 401 on the pharmacist's town of residence, and in section 402 on hours when the pharmacist must be present at the pharmacy to refer only to "establishments" or "pharmacies" in Puerto Rico. Accordingly, the Court holds that these provisions are not applicable to the management and operation of National's business in New Jersey. These provisions cannot be used to prevent National from servicing customers in Puerto Rico. Because the Court holds that these provisions, as construed in this opinion, do not apply to National, the Court need not address at this time National's argument that the provisions constitute an undue burden on interstate commerce. Accordingly, this argument is denied without prejudice. The conclusion that these laws should only apply to pharmacies in Puerto Rico and not to National's operations is supported by a second reason. The Pharmacy Act was enacted in 1945; the statutes which created the Colegio took effect in 1938. See 1945 Laws of Puerto Rico No. 282, at 998-1034, May 15, 1945; 1938 Laws of Puerto Rico No. 243, at 458-63, May 15, 1938. Although the laws have been amended over the years, they have not been substantially changed, at least not in any way relevant to the present controversy. It is evident from the language of the statutes that they were not enacted with mail-order pharmacies in mind: nowhere is there any mention of them. This is not surprising, given the fact that mail-order *60 pharmacies a la National's operations did not exist at the time these statutes were originally enacted.[24] Based on a reading of the laws as a whole and on their historical context, it is apparent that Puerto Rico's pharmacy laws were drafted with the intention of regulating and licensing only those pharmacies that were operated and located in Puerto Rico. National's recourse, then, is to seek a license from the Secretary of Health and to register with the Board of Pharmacy. The Court recognizes that the Puerto Rico pharmacy laws do not specifically provide for mail-order pharmacies. This is an oversight which can be readily corrected. The statutes and regulations of a number of states offer a wide range of examples on how to deal with this industry. In all, at least thirty-eight states have enacted measures on mail-order pharmacies. See Ala. Code § 34-23-31; Alaska Stat. § 08.80.158; Ark.Code Ann. § 17-92-401; Cal.Bus. & Prof.Code § 4112; Colo.Rev. Stat.Ann. § 12-22-130; Conn.Gen.Stat. Ann. §§ 20-627 to 20-630; Del.Code Ann. tit. 24, §§ 2538 - 2540; Fla.Stat. ch. 465.0156; Haw.Rev.Stat. § 461-15; Idaho Code §§ 54-1743 to 54-1748; 225 Ill. Comp.Stat. 85/16a; Ind.Code. § 25-26-13-17; Iowa Code § 155A.13A; Kan.Stat.Ann. § 65-1657; Ky.Rev.Stat.Ann. § 315.0351; La.Rev.Stat.Ann. §§ 2702 - 2704; Me.Rev. Stat.Ann. tit. 32, §§ 13721, 13751; Md. Code Ann., Health Occ. § 12-403; Mich. Comp.Laws § 333.17748; Minn.Stat. § 151.19; Miss.Code.Ann. § 73-21-106; Mo.Ann.Stat. § 338.337; Mont.Code Ann. § 37-7-703; Neb.Rev.Stat. § 71-2407; Nev.Rev.Stat. § 639.2328; N.M.Stat.Ann. § 61-11-14.1; N.C.Gen.Stat. § 90-85.21A; N.D.Cent.Code § 43-15-34.1; Or.Admin.R. 855-041-0300; S.C.Code Ann. § 40-43-83; S.D. Codified Laws §§ 36-11-19.2 to 36-11-19.9; Tenn.Code Ann. § 63-10-410; Tex. Health Code Ann. 4542a-1; Utah Code §§ 58-17a-102 & 58-17a-303; Va.Code Ann. § 54.1-3434.1; Wash.Rev.Code §§ 18.64.350 to 18.64.400; W.Va.Code § 30-5-6a; Wyo.Stat.Ann. § 33-24-152. A provision on mail-order pharmacy may be as simple as a single administrative regulation. For example, Oregon's administrative rules require simply that any mail-order pharmacy shall be registered with Oregon's Board of Pharmacy, be registered in good standing in the state where it is located, and designate one of its pharmacists to be responsible for all prescriptions delivered to Oregon residents. Or.Admin.R. 855-041-0300. Missouri has a statute which is similarly concise. It requires only that any out-of-state pharmacy be licensed with Missouri's board of pharmacy. Mo.Ann.Stat. § 338.337. Other states have more complex requirements. Nevada mandates that any mail-order pharmacy be licensed with the state board; that it also be licensed in the state where it is located; that it comply with all federal laws and regulations; and that it submit evidence that its facility and records comply with the laws of the state where it is located. Nev.Rev.Stat. § 639.2328. California requires that every out-of-state mail-order pharmacy register with the California board of pharmacy; provide the names of its agent for service of process in California, its pharmacists, and its corporate officers; comply with the pharmacy laws of the state where it is located; keep records of all controlled substances or potentially dangerous drugs dispensed to California customers; and maintain a tollfree *61 telephone service to allow for communications between California patients and pharmacists at the mail-order pharmacy. Cal.Bus. & Prof.Code § 4112. Delaware, Iowa, and Kansas all have statutes with requirements comparable to those of California's, including that for a toll-free telephone number for customer questions. Del.Code Ann. tit. 24, §§ 2538-2540; Iowa Code § 155A.13A; Kan.Stat.Ann. § 65-1657. The Court, of course, makes no judgment as to which of the variety of state statutes would best enable Puerto Rico to regulate mail-order pharmacy.[25] The Court holds only that the challenged provisions in sections 396, 401, and 402 that a prescription for a Puerto Rico patient may only be filled by a pharmacist residing in the town where his pharmacy is located, that a pharmacist must be present at the pharmacy he manages for a specified number of hours per week, and that any pharmacy be subject to inspections by the Secretary of Health do not apply to pharmacies outside of Puerto Rico and, so construed, do not unconstitutionally burden interstate commerce. Declaratory judgment shall be entered to this effect. National's proper recourse is to seek licensing and registration from the appropriate Puerto Rico authorities. And because the above-mentioned provisions of sections 396, 401, and 402 do not apply to out-of-state pharmacies, National may not be denied a license or registration on the grounds that it does not comply with these provisions.[26] WHEREFORE, the Court denies without prejudice National's challenge to the constitutionality of the above-discussed statutes regulating the practicing of pharmacy in Puerto Rico. Declaratory judgment shall be entered holding that the provision of 20 L.P.R.A. § 396 requiring that a pharmacy be subject to inspections by the Secretary of Health, the provision of 20 L.P.R.A. § 401 requiring that a pharmacist reside in the town where his or her pharmacy is located, and the provision in 20 L.P.R.A. § 402 specifying the number of hours per week that a pharmac

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the circuit court and the evidence in the record do not establish a sufficient connection between Tolson's tortious actions and his work for the State. Appellants claim that Tolson's abuse of his authority to coerce Cravens and to sexually assault him cannot be deemed to have arisen out of Tolson's employment or to have been performed in connection with his official duties on behalf of the State. Appellants argue that the sexual assault of Cravens did not serve to benefit the State in any way and, therefore, cannot be deemed related to the employment. Interpreting a statute and determining whether it applies to a given set of facts are questions of law which this court reviews de novo. Boggs ex rel. Boggs v. Lay, 164 S.W.3d 4, 23 (Mo.App. E.D.2005). We must give effect to the language of a statute as written and will not add words or requirements by implication where the statute is not ambiguous. McCormack v. Capital Elec. Constr. Co., 159 S.W.3d 387, 402 (Mo.App. W.D.2004). "The plain language of [§ 105.711] provides coverage for conduct of an employee `arising out of and performed in connection with his or her official duties.'" Betts-Lucas v. Hartmann, 87 S.W.3d 310, 321 (Mo.App. W.D.2002). "The Fund is merely a voluntary assumption of defense and payment of judgments or claims against state employee (sic) sued for their conduct arising out of and performed in connection with official duties on behalf of the state." Dixon v. Holden, 923 S.W.2d 370, 379 (Mo.App. W.D.1996) ("Dixon I"). This Court has "expressly noted that there was no criminal conduct exception and the legislature, if it desired a policy favoring one, should reconsider the Fund statute."[2]Betts-Lucas, 87 *448 S.W.3d at 321. Section 105.711 likewise contains no requirement that the employee be acting "in good faith" in performing the acts giving rise the underlying cause of action.[3]Dixon I, 923 S.W.2d at 379. The Legislature has not seen fit to amend the statute to include any such exceptions. Dixon I "made abundantly clear . . . a § 1983 claim for denial of constitutional rights under color of state law is covered in the State Legal Expense Fund, § 105.711.2." Dixon v. Holden, 963 S.W.2d 306, 307 (Mo.App. W.D.1997) ("Dixon II"). In the case at bar, the federal district court found that Tolson had violated Cravens's constitutional rights under color of law. In subsequently issuing its writ, the state circuit court found that Tolson was charged by the State with the care and custody of Cravens and that he had used the authority granted to him by the State to perpetrate the sexual assaults on Cravens. The circuit court even found that Tolson's acts were done, in part, as an official form of punishment for Cravens's violation of prison rules.[4] Under the foregoing findings of fact, Tolson's actions constituted conduct arising out of and performed in connection with his official duties. The circuit court did not misinterpret or misapply the law in concluding that the judgment against Tolson entered in the federal district court was covered by § 105.711. Point denied. In their second point, Appellants claim that the circuit court erroneously concluded that it was bound by the findings of the federal district court because they were not parties to that action and because the issue of whether § 105.711 applied was not fully litigated in that case. Appellants further argue that "[t]he federal court lacked jurisdiction to adjudicate whether an intentional sexual assault was conduct arising out of and performed in connection with an employee's official duties." In its judgment, the circuit court did conclude that the federal judgment was binding as to whether the Tolson's conduct was covered by the Legal Expense Fund. However, the circuit court also independently found that Tolson's conduct arose out of and was performed in connection with his official duties. Since we have already determined that the latter finding was proper, we need not consider whether the circuit court's impression of the binding nature of the federal court's findings was correct. As noted supra, when reviewing the judgment in a court tried case, this court must affirm under any reasonable theory supported by the evidence. Klokkenga, 200 S.W.3d at 152. Point denied. In their third point, Appellants claim that the circuit court erred in ordering them to pay the judgment entered against Tolson because any judgment against them was barred by the doctrine of sovereign immunity. Appellants contend that the language of § 105.726.1, RSMo Cum.Supp. 2005, providing that "Sections 105.711 to *449 105.726 do not waive the sovereign immunity of the State of Missouri," served to bar judgment against them in this case. "Sovereign immunity is a judicial doctrine that precludes bringing suit against the government without its consent. It bars holding the government or its political subdivisions liable for the torts of its officers or agents unless such immunity is expressly waived." State ex rel. Div. of Motor Carrier & R.R. Safety v. Russell, 91 S.W.3d 612, 615 (Mo. banc 2002). "Sovereign immunity, if not waived, bars suits against employees in their official capacity, as such suits are essentially direct claims against the state." Betts-Lucas, 87 S.W.3d at 327. Sovereign immunity is simply not applicable to this case. "The legislative provisions creating the Legal Defense Fund constitute[] `a voluntary assumption of defense and payment of judgments or claims against state employees sued for their conduct arising out of and performed in connection with official duties on behalf of the state.'" Id. at 327-28 (quoting Dixon I, 923 S.W.2d at 379). "[S]overeign immunity [is] not available as a defense by the State to actions seeking recovery from the [Legal Expense] Fund, given that the underlying litigation is against state employees, rather than the state itself." Id. at 320.[5] Nothing in the revised language of § 105.726.1 changes that fact. Point denied. In their final point, Appellants assert that the circuit court erred in awarding Cravens attorney's fees related to his mandamus action. They contend that such an award is not specifically authorized by statute and is, therefore, precluded under the State's sovereign immunity. In making this argument, Appellants ask us to overrule our holding in Dixon v. Holden, 963 S.W.2d 306, 308 (Mo.App. W.D.1997), approving a similar award of attorneys fees that were incurred in bringing a declaratory judgment action to collect payment of a judgment from the Legal Expense Fund. We decline Appellant's invitation to reconsider the reasoning of Dixon II. In Dixon II, the plaintiff obtained a judgment against two state employees under 42 U.S.C. § 1983 and, after the State refused to pay the judgment, filed a declaratory judgment action against the State Treasurer and Commissioner of Administration asking for a declaration that the State was responsible for satisfying that judgment from the Legal Expense Fund. Id. at 307. After obtaining such a declaration, the plaintiff filed an application for attorneys' fees expended in collecting on the judgment from the State. Id. In reversing the trial court's denial of that motion for attorney's fees, this Court noted that "Section 1988(b) of the Civil Rights Attorney's Fees Awards Act specifically allows a court to award the successful party attorney fees as costs in any action or proceeding to enforce rights claimed to have been denied under § 1983" and that "state courts may award attorney fees as costs pursuant to § 1988." Id. at 308. We held that the defendants were subject to an award of attorney's fees under § 1988 and that sovereign immunity did not shield them from such an award. Id. Appellants offer no reason to differentiate Cravens's application for attorney's fees in this mandamus action from *450 the application filed in the declaratory judgment action in Dixon II, and we perceive of no reason to treat them differently. The circuit court had the authority to enter an award of attorney's fees under § 1988, and sovereign immunity does not serve to bar such an award.[6]Id. Point denied. The judgment is affirmed. All concur. NOTES [1] In its judgment, the U.S. District Court found, in relevant part: 4. Defendant Tolson was employed by the Department of Corrections as a food service cook at Algoa, during the time Plaintiff was incarcerated at Algoa. 5. As part of his duties, Tolson, supervised the inmate line cooks that worked in Algoa's bakery. Tolson's supervisory duties allowed him to spend unmonitored time with inmates. 6. Plaintiff worked in the bakery at Algoa in February 2004. 7. Plaintiff was supervised in the bakery by Tolson. 8. On three occasions, Tolson engaged in forcible oral sex with Plaintiff during Plaintiff's work hours in the bakery. 9. Plaintiff did not consent to any of the episodes of oral sex. 10. Tolson used physical force, threats, and coercion in order to engage in oral sex with Plaintiff. 11. On two other occasions, Tolson forcibly placed Plaintiff's penis in his rectum. Plaintiff performed anal sex on Tolson out of fear he would be harmed if he did not. 12. Approximately three weeks prior

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worst headache to be faced was that it was still high summer. Aircraft dropping supplies for Resistance groups in Yugoslavia, or even Czechoslovakia, could leave after dark and return before dawn; but a trip to central Poland meant a five-hour flight each way and, allowing an hour for the pick-up, that meant that the aircraft could not leave Brindisi much after seven o'clock; so it would still be light enough for it to be spotted by German fighters when it passed over the northern Adriatic. A Dakota with additional fuel tanks had been laid on for the job, and at a conference next day it was decided to guard against possible interception by sending a Liberator to escort it on the first part of its journey. At the conference Gregory met the crew of the Dakota that was to fly him in. The Captain of the aircraft was Wing Commander Frencombe of No. 267 Squadron, the pilot Flight Lieutenant Culliford, the navigator Flight Lieutenant Williams, the W/T operator Flight Sergeant Appleby, and a Polish Flying Officer, K. Szaajer, from the Polish Flight had been seconded to act as interpreter if necessary. Everything had been made ready to carry out the operation that night but the Met. report was unfavourable, so with keyed-up nerves they waited to see if the next day would bring an improvement. It did, so on the evening of the 25th they made their final preparations. Soon after seven o'clock they went out on to the airfield. A last check-up was made on the Dakota KG.447 then, clad in windproof clothing and wrapped in rugs to keep them as warm as possible during their long cold journey, at 19.37 hours they took off. While over the Adriatic they were spotted by German patrol-boats that carried anti-aircraft guns, but were flying sufficiently high to escape the flak that was loosed off at them. By half past eight they were over Yugoslavia and a little before ten o'clock when they were approaching Budapest, darkness having fallen, their escorting Liberator turned back and left them. With a steady hum the Dakota soughed on over Hungary and Czechoslovakia. For a good part of the flight Gregory slept, then half an hour after midnight Flight Lieutenant Williams roused him to tell him that they were approaching their destination. The aircraft was steadily coming down from the great height at which it had been flying, so he took off his oxygen mask and went forward into the cockpit. To check the features of the country far below with the map was anything but easy, as there were patches of drifting cloud that now and then obscured the moon for up to two minutes at a time, and when the moonlight did glint on water the whole of the area to the north-east of Warsaw was so intersected by the rivers Liwiec, Bug and Narew, with their many tributaries, that Gregory began to fear that he would not be able to identify the two forks between which lay Malacou's cottage. For some fifteen minutes he and Williams peered down, sweeping the landscape with powerful night glasses, then the Flight Lieutenant said, 'We've overshot it. We must have by now,' and told the pilot to turn back. The aircraft heeled over as Culliford brought her round. Just as he straightened out a pair of searchlights suddenly came into action away to the west and in wide arcs began to sweep the sky. As the Captain of the aircraft muttered a curse another pair opened up to the south, then a third pair almost immediately below them. It was evident that the German listening posts had picked up the sound of their engines. The pilot banked the aircraft, then put her into a steep dive. As Gregory righted himself from a lurch Williams shouted to reassure him. 'Our trips over Poland are so infrequent that there's a good chance they'll take us for one of theirs that has got off course. Unless they catch us in a beam and identify us as an enemy they won't shoot.' Culliford had brought the aircraft down to five hundred feet, so it was now well below the angle at which the searchlights were sweeping. Two minutes later Gregory heard Malacou's voice as clearly as though he had been in the 'plane, calling, 'Here! Here! Come down! Come down!' Staring earthward he suddenly recognised the bend in the big river near which the cottage lay, then the road to Rózan some way to the north of it. Putting one hand quickly on the pilot's shoulder, he pointed downward with the other. Culliford nodded, turned the aircraft in a wide sweep and shut off his engine. Slowly she sank, then, bumping only slightly, taxied to a halt on the long straight road that ran through the marshes. Gregory, Williams and Szaajer scrambled out and looked quickly about them. A cloud had just obscured the moon again, but next moment they spotted a torch being flashed at intervals some quarter of a mile away. While the three of them ran towards it the others remained in the aircraft so that if need be it could make a quick getaway. As they approached, the flashes from the torch ceased and they all drew their pistols in case they were walking into a trap. But Gregory went forward confidently, because for several hours past, except during his sleep in the aircraft, he had been concentrating on letting Malacou know that the pick-up was to be that night, and the occultist's clear call to him, only five minutes earlier, confirmed that his telepathic communication had been received. The moon suddenly came out again and two figures emerged from a patch of tall reeds at the roadside. Malacou stepped forward and cried joyfully, 'Mr. Sallust, I knew that I could not be mistaken, and that you were on your way. It is a great relief that you have got here safely.' He then introduced his companion as the Polish engineer Mr. Kocjan. When Gregory had introduced the others Kocjan, also speaking German, pointed at the searchlight beams and said quickly, 'Now that they have lost the sound of your engines they will know that the 'plane must have come down, and may suspect that it is British. It might have landed several miles from here, so there is no cause for panic. But, all the same, we must not lose a moment. Come; follow me.' Turning, he led them at a loping run along a winding path fringed by tall fields of reeds and occasional patches of water. Ten minutes later they reached the cottage. The windows were blacked-out, but an oil lamp was burning in the living room and Gregory saw that two men dressed in rough farm clothes were silently waiting there. As they came to their feet, Kocjan said: 'These are two of my brave fellows. There are many packages to carry to the 'plane so I wish I could have collected more men, but this was the best I could do at such short notice.' Malacou, still breathing heavily from having had to run, stepped over to the stove and said, 'I thought that after your long flight you would be half frozen; so I have here some soup for you.' Pouring the steaming liquid into three bowls, he handed them to Gregory, Williams and Szaajer. 'It's very welcome,' Gregory smiled, and Szaajer broke off a conversation he had started with the two farm workers to bow his thanks. But Kocjan said abruptly, 'Drink quickly, please. We shall need every hand.' Then he signed to his helpers and they followed him out of the room. While Gregory sipped at the scalding soup, Malacou confirmed in words the misfortunes that had befallen him during the past six months, giving a brief version of the thoughts he had conveyed by telepathy. As soon as they had finished he led them outside and round to a woodshed at the back of the cottage. It was lit by another oil lamp and Gregory saw that the two farm workers had already left with a first load. But Kocjan was there and the hunchback Tarik, who was helping him load a packing case on to a low, two-wheeled truck. Beyond them lay a pile of at least a score of roughly made crates and bundles. As Gregory's glance fell on them, he exclaimed uneasily in German: 'Good God, what a mass of stuff! If all that pile contains metal parts they must weigh a ton.' 'No, nothing like it,' grunted the Pole. 'It is the awkward shape of many pieces that makes them appear so bulky, and several of the cases contain documents we succeeded in stealing in a raid we made on a German headquarters. They may prove valuable, although not in the class of the rocket. We managed to prise off the tail, so have the whole works and have reason to be proud of our achievement.' 'You certainly have,' Gregory agreed. 'I'm only wondering if the aircraft can take it all. She's fitted with additional fuel tanks, of course; but she needs every gallon for her fourteen-hundred-mile flight here and back.' Then he turned to Williams and asked him in English what he thought. The Flight Lieutenant shrugged. 'We have room enough for it, but there's more of it than I expected. If he is right about the pieces not weighing a great deal we'll make it.' 'Come now! You waste time talking,' cut in the Pole angrily. 'Do you not realise that those S.D. swine are

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reminded him, sidling toward the armory door. "I'm protected by Anothosia as long as I carry the baby." "You trusted me after the protection was cast," Pol said. "That makes me immune. Now, darling, it's no use looking at the door. You'll never get it unbarred in time, and you might as well forget trying to stab me with a sword. The enjoyable thing about my kind of chameleon is we aren't bothered by steal." Straightening, he lifted the sword. "I wish I could say I'm sorry, but I can't. I like you well enough, but I've a pleasant job to do and no conscience at all. I can't even promise this will be quick since I like playing with my toys." "Me, too," Elise said when she felt the door's bar press into her back. Reaching up, she grasped Wynderfyte and pulled the war hammer down from its supports. She dropped the knife from her left hand and reached up to grasp a shield. Shifting her fingers, she adjusted her grip on the hammer's shaft and wished she had leisure to slide her arm through the shield's arm strap. As it was, she could only grasp the shield by its center handle, making her hold of it awkward. "We never practiced with a hammer," Pol pointed out. His eyes laughed at her naivety, mocked her, and then he lunged in for an attack. He struck high, low, and then tried to slice the artery under her arm. Frightened, Elise ducked and dodged. She twisted free of one blow, caught one on the shield, and another struck Wynderfyte's metal shaft, sending up a rather unimpressive shower of sparks. "I know," Elise replied, and she swung Wynderfyte with all the fear she possessed. The hammer struck Pol's sword, almost sweeping it from his hand. "You should have found yourself a shield," she added helpfully. "This hammer might be a tad bit slow, but your pointed stick is far too light to block me." Nervous sweat ran into her eyes, blurring her vision and making her eyes sting. Risking a quick swipe with her shield arm's sleeve, she wished she had a rag to tie around her head. "I'm still immune to steel," Pol pointed out. His hooded eyes appeared amused and contemptuous. Laughter bubbled lightly on his lips, "Still, you are right. Your hammer is very slow." His arm flickered and fire ran along Elise's ribs. She gasped, stumbled, and prayed to Anothosia for her child's life. Pol struck again and yet once more. He moved with a speed and flexibility he had never shown her before. Elise caught two strikes on her shield, twisted to avoid another, and then the thin steel blade slashed into her left thigh before she could leap away. She cursed, glanced down, and saw she bled from a gash. "Pity you won't live," Pol observed. "The cut would have made a wonderfully ugly scar." "It won't be my first," Elise panted. She hurt in more places than she should, which meant she bore more wounds than she knew. It was only a matter of time before she became too weak to defend herself. Already, her leg trembled and threatened to give way. "Oh?" Pol raised an inquisitive eyebrow. "My father," Elise said, "insists all his children have some taste of war." Stepping forward, she swung Wynderfyte with all her might. Pol moved to block, but Elise slammed her wooden shield into him, and the hammer cracked into Pol's left shoulder. Pol cursed, stumbled, and fell back, his shoulder a ruin. Feeling grim satisfaction, Elise followed. "There's a difference between iron and steel," she said with a grin. "Olnac made himself king with this weapon because he was too poor to afford a sword." She swung again and cursed her weak arm. The hammer was heavy, and she had already lost too much blood. Pol's sword deflected her slow strike, but she slammed into him with her shield once more. The shield shivered in her hand when it hit his defending arm, almost falling from her weak grip, but Elise maintained control. She struck once and then twice with shorter and weaker war hammer blows. The heavy iron glanced off Pol's head to crack into his injured shoulder once more. Crying out, he staggered back, stopped, and lunged forward just in time to meet the hammer once again. Wynderfyte crushed flesh and bone beneath its unforgiving weight. Sweat streaming down his face and blood running from a tear in his scalp. Pol swayed before her, unsteady, broken, one eye fallen free from a crushed socket. Realization and despair bled from his remaining eye as Pol opened his fingers, the sword falling from his slack grip. "I was right when I said you have a warrior's heart," Pol whispered, and then Elise swung Wynderfyte with all the remaining strength she possessed, using her legs and back to amplify its force. Wynderfyte crashed into his face, breaking his jaw, sending jagged shards of broken teeth flying through a mist of blood. He fell, but Elise did not stop swinging. The hammer cracked into Pol again and again, breaking his body beneath its weight until, exhausted, Elise fell to her knees and the hammer slipped from her hand. She stayed there, swaying while she searched within herself for some promise the king's unborn heir still lived. Peace settled over her and warmth. Her mind wandered, opened, and Anothosia's grace momentarily filled her soul. Dripping blood slowed, stopped, and Elise's ripped flesh healed. New strength filled her. A muted and insistent pounding sounded on the thick oak door. Rising, Elise felt no surprise at finding her shredded dress was clean and whole. Not a drop of blood stained it, not a wrinkle showed, but she still had blood on her hands. "Why?" Elise asked the air. "Calto," Anothosia answered within her mind. The pounding stopped and the ring of axes on wood started. Elise listened while watching Pol's features shift. The remnants of his handsome mien became coarse and disjointed. Below the ruin of his inhuman face lay a misshapen body with almost no unbroken bones. Looking down on her work, Elise smiled. Not even the gods of Hell could reform this body. She had made sure of it. If Pol were to live once more, Zorce would have to form him a new body, a spawn's body, for Pol's spirit was not strong enough to claim anything more. Though he had played her for a fool, he had been a fool to believe the gods of Hell would grant him strong life and great strength for dying while failing to fulfill their will. Finally, the crack of weapons and tools on the door ceased when the door broke open. Men bearing weapons poured in, but their weapons lowered among a united sound of startled gasps. King Vere stepped past the gathered guards, stared first with unbelieving eyes at Pol before he turned those eyes on her. "How? How could you do this?" he demanded. "This is murder." "This is justice," Elise lied. "He tried to rape me, and I became angry." She gave her husband a long, studying stare before allowing one corner of her lips to form a partial smile. "I've decided on a name for your heir. We'll call him Olnac, after your grandfather, because he knew iron sometimes has more worth than steel." "Murder," her husband whispered, but his voice shook. They both knew the charge could not stand. Pol Swordbreaker was obviously hellkind. No court in all of Yernden would convict any of its citizens for killing one of Zorce's followers. Not now. Not yet. Knowing this, Queen Elise allowed her smile to become full, bright, and without concern. She leaned over to grasp Wynderfyte's handle, straightened, and lightly rested her other blood smeared hand on her husband's corpulent cheek. "Try to divorce me," she whispered, gently patting him, "and watch me really get mad." Fastening her eyes on Belsac's scowling face, she narrowed her eyes. Then she laughed. Chapter 11— A Matter of Forgiveness Anithia straightened her tunic and grasped Missa's hand tighter while quickstepping her way home from brood-mother Kali's, the only safe place she had found to leave her daughter while she worked. Looking around, she tried to wear her 'don't fuck with me' attitude, but with her feet thudding dully on the cracked boardwalk and her mouth twitching nervously, she knew she failed. They passed a young pickpocket who made a laughing comment to two friends before he leered at her breasts and made an obscene gesture, indicating exactly what he would like to do to her. Mouth dry, Anithia touched her knife's comforting handle before narrowing her eyes and staring back, letting him know she was nobody's easy victim. Larson, gods bless the sorry bastard who had died and left her alone, had spent a good deal of time making sure she knew how to handle herself when threatened. She might not be able

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outgrowing cells after plating of sheet 1\. sheet 30,000 *BSS, balanced salt solution; CFHE, calcium-free Hank's EDTA; DMEM, Dulbecco's modified Eagle's medium; P, postnatal day; RT, room temperature; N/S, not stated. \* = incubation of the whole eye in protease with subsequent dissection (globe) or dissection of the eye and incubation of sclera, choroid and RPE sheet in proteinase (sheet) with or without retina, or incubation of the RPE layer with or without retina. \*\* = yield per eye ball. \*\*\* = Pinzon-Duarte et al. ([@B66]) did not culture RPE cells but isolated the retina with intact attached sheets of RPE cells. \*\*\*\* = Wang et al. ([@B85]) and Kreppel et al. ([@B48]) did not isolate RPE cells for extensive culturing but to test virus infection or to use the cells for biochemical assays, respectively*. To achieve a more reliable method and a higher yield from adult rats, we systematically developed and validated a new way to isolate RPE cells. Our protocol is fast, easy and efficient and would provide a valuable tool for the study of AMD and other diseases involving RPE pathology. Our culture method of rodent adult RPE cells is based on the digestion of the whole eye in papain. We demonstrated the success of the culturing protocol using two-month old rat eyes. However, the method is widely applicable to other animals, such as mice, with slight modifications. The protocol provides a useful RPE cell culture model which can be used to evaluate the behavior of adult RPE cells when subjected to certain stresses *in vitro*, giving a result more reminiscent to the disease situation. Also, the cultured cells can be transplanted directly in common animal models of retinal degeneration such as the Royal College of Surgeon's (RCS) rat. We assessed our method by comparing cell yield, growth characteristics, the expression of RPE markers and the adhesion of the cells to Bruch's membrane components to previous data reported in the literature. Materials and Methods {#s2} ===================== RPE Cell Culture {#s2-1} ---------------- All animal work was carried out in accordance with the UK Animals (Scientific Procedures) Act 139 (1986) and within UK Home Office regulations. Animal experiments and designs were covered under Project licence 80/2360 approved by the Home Office. Adult Lister Hooded or Sprague Dawley (SD) rats (Charles River; 250--300 g, 8--10 weeks) were used for tissue. The rats were kept in standard housing conditions with 12 h light/dark cycle in a temperature-controlled room (22°C) with free access to food and water. A detailed step-by-step guide to the process is illustrated in Figure [1](#F1){ref-type="fig"} Rats were culled by exposure to rising concentration of CO~2~ followed by dislocation of the neck. Eyes were dissected out, and excess muscle and connective tissue were removed in ice cold phosphate-buffered saline (PBS). The eyes were then incubated in a 20 U/ml papain solution (Worthington PDS Kit) for up to 1 h at 37°C in a 24-well-plate. Four eyes can be placed in one well of the plate, and 1 ml of the papain solution should cover all eyes. Afterwards, eyes were transferred to DMEM supplemented with 10% fetal bovine serum (FBS) to stop the papain digestion. Using a needle (21 gauge, BD Microlance), a hole was introduced close to and an incision was made along the ora serrata to remove the lens and cornea-iris. The earlier digestion with papain allowed the retina to be pulled out readily, leaving the choroid-sclera complex behind. At this point, the RPE cells were still attached to the retina. The retina/RPE complex was further digested in 1 ml of fresh 20 U/ml papain for \~10 min at 37°C. By means of fine forceps, the RPE sheets were peeled off the retina. The sheets were incubated in trypsin (1 mg/ml in PBS, Sigma) and then triturated to achieve smaller patches of RPE cells. The trypsin cell solution was diluted with Dulbeccos modified Eagles medium (DMEM) supplemented with 10% FBS and washed through centrifugation. RPE cells (different cell numbers, see below) were plated on matrigel-coated (BD Biosciences; 1:80 in ice-cold DMEM and then incubated overnight at 37°C) culture dishes in "Miller" medium (DMEM supplemented with 20% FBS, N1 medium supplement, MEM-non-essential amino acids, 2 mM GlutaMAX^™^-I, 250 μg/ml taurine, 20 ng/ml hydrocortisone, 13 ng/ml triiodothyronin and antibiotics; Maminishkis et al., [@B56]; Sonoda et al., [@B74]). The next day, the medium was changed to "Miller" medium supplemented with only 5% FBS. Medium was changed twice a week. ![**Dissection of retinal pigment epithelial (RPE) cells using papain.** First, rats were sacrificed using CO~2~ and dislocation of the neck. Then, eyes were dissected out, placed in phosphate-buffered saline (PBS) and excess connective tissue and muscle attachments were removed. Afterwards, the whole eye was incubated in papain (20 U/ml, Worthington PDS Kit) for up to 1 h at 37°C. The papain digestion was stopped by the addition of DMEM supplemented with 10% fetal bovine serum (FBS). Using a needle, a hole was introduced into the globe near the ora serrata, and the anterior part of the eye was cut away (following the red dotted line). Afterwards, the retina was carefully removed, and the choroid-sclera sheet was discarded. The RPE cells were still attached to the retina (pigmented cells in figure). The retina was then incubated for another 10 min in papain (20 U/ml) to loosen the RPE sheets which were then peeled off and incubated in trypsin (1 mg/ml) and triturated to achieve a single cell solution. Finally, the RPE cells were plated in "Miller" medium (DMEM supplemented with 20% FBS, N1 medium supplement, MEM-non-essential amino acids, 2 mM GlutaMAX^™^-I, 250 μg/ml taurine, 20 ng/ml hydrocortisone, 13 ng/ml triiodothyronin and antibiotics) on matrigel (1:80 in DMEM)-coated dishes.](fncel-09-00449-g0001){#F1} Immunochemistry {#s2-2} --------------- Animals were perfused transcardially with 4% paraformaldehyde (PFA, Sigma) in 0.1 M PBS, pH 7.2--7.4, after an overdose of general anesthetic \[Euthatal (200 mg/ml solution, Rhône-Mérieux)\]. Eyes were dissected out, and lens and anterior chamber were carefully removed together with the vitreous humor. Care has to be taken to not destroy or detach the retina. The eyes were immediately post-fixed in 4% PFA overnight at 4°C. The tissue was transferred into 30% sucrose (Sigma) in PBS, for cryoprotection. Sections of 14 μm thickness were cut on a cryostat (Cryostat Leica CM 3050S) and mounted on glass slides (Superfrost^®^ Plus, VWR). The sections were washed three times with PBS. Subsequently, the tissue was permeabilized and blocked using PBS supplemented with 0.3% Triton-X 100 (Vector labs; PBST) and 10% donkey serum (Sigma; PBST-S) for 1 h at room temperature (RT). Afterwards, sections were incubated in primary antibody solution (antibody diluted in 5% PBST-S (Table [2](#T2){ref-type="table"}) overnight (\~14--16 h) at 4°C. The next day, sections were washed three times for 5--10 min each with PBST followed by the addition of secondary antibody solution (Alexa488- or Alexa568-coupled donkey anti-rabbit or donkey anti-mouse (Invitrogen) diluted in PBST-S). After 1--2 h of incubation at RT, the tissue was incubated for 5 min in PBS supplemented with HOECHST-33342 (2 μg/ml, Sigma) to stain for nuclei. Afterwards, the sections were washed again three times for at least 10 min with PBST. Finally, the sections were sealed with a coverslip using Fluorosave^™^ (Calbiochem). ###### **Primary antibodies used**. Antigen Host Clone Supplier Product Code ---------------- -------- -------------- ------------ -------------- Basigin Rabbit EPR4052 Abcam ab108317 Collagen IV Rabbit pc\* Abcam ab19808 CRALBP Mouse B2 Novus NB100--74392 Cytokeratin 18 Mouse C--04 Abcam ab668 Fibronectin Rabbit pc Sigma F3648 Laminin Rabbit pc Sigma l9393 MERTK Rabbit pc Abcam ab95925 OTX-2 Rabbit pc Millipore AB9566 RPE65 Mouse 401.8B11.3D9 Millipore MAB5428 ZO--1 Rabbit pc Invitrogen

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of Forge. Forge is like gauntlet, except you draft your deck out of a random selection of cards, in a fashion you will feel familiar with if you played Hearthstone’s Arena or Duelyst’s Gauntlet before. A key difference with the above is that in Eternal, you get to keep the cards you pick for your collection! Another important thing you need to know about Forge is that you will only be given choices from two factions, based on the first picks you make. This means that you can “force” the factions you need cards in. I invite you to do just that for Rakano, which also happens to be a strong faction pairing for limited formats anyway! The makings of a solid Rakano deck (regardless of budget) Before we actually start the Forge run, a few words about what the deck we’re aiming for looks like. There is more than one way to build a good Rakano deck. Today we’ll focus on the most common aggro archetype, commonly referred to as “pants” (due to its heavy use of weapons). It’s a relatively simple to play style of deck which is both very effective and easy to build across a wide budget range. Without naming specific cards, and with of course a fair amount of leeway on the numbers in each category to accommodate for specifics and techs, the deck will typically break down like this: 8 to 12 one-cost units 10 to 14 two-cost units 0 to 6 three-cost units 10 to 14 one or two-cost weapons (“cheap pants”) 4 to 8 three+ cost weapons (“fancy pants”) 4 to 10 Removal spells, tricks, or relics 25 or 26 Power As you can see, this is clearly an aggro deck, with a curve very low to the ground. It is built to make sure that you are most likely to fully utilize your mana on turns 1-4, quickly building a board of threats. Your opponent should immediately be on the back foot, and their slow draws will be punished hard. We play almost no cards that cost more than 3, so we can afford to play the minimum amount of power thanks to the mulligan rule (which guarantees you at least 2 power cards if you redraw your starting hand). The power should include as many duals as possible (both seats and banners) as well as Diplomatic Seals when you get them, and possibly a few Monuments to taste. I personally like two copies of Emerald Monument. In each category, there is a fair amount of leeway in what to use; the deck will function whether you have 4 copies of each best in slot rares (when there is even one) or a bunch of disparate commons, which is fortunate because we’ll have to do with the latter for a while. The reason I’m giving you these categories and approximate numbers for them rather than simply decklists is that, while it is entirely possible to craft most of the lower rarity stuff you need early on, it’s inefficient in terms of growing a collection – so we’ll try to avoid it as much as possible. Between the large packs, cards in chests, and limited modes letting you keep cards, Eternal gives out a whole lot of those low rarity cards. You’ll get full playsets of them very quickly! The flip side of that is that the crafting/recycling rates on them is very disadvantageous. With that in mind, I believe the best budget decks are those made out of whatever you have, rather than out of “cheap crafts”, which are actually the worst investment you can make. We will get to crafting eventually, but only after getting as many “free” cards as possible to make a base deck out of. Card rankings per category OK, so now you are ready to start your first forge run to populate that future deck of yours. But what do you pick? You already know to make your first picks either Justice (green) or Fire (red), but which cards are good? Well, here’s a handy table to answer that question! Anything on top of each of these categories should be a priority pick. In Forge, you only get picks of similar rarity at any given time, so you don’t need to “rare-draft”; only go for higher rated stuff. The exception is you’ll sometimes be given the choice of a Legendary over rares; unless the rare is high up in this table and the legendary looks lame, I say take the legendary in that the case. If you’re referring to this table in the context of drafting, it’s better to give some amount of priority to rares over C/Us. Common or Uncommon can be used as a tie-breaker in case you’re unsure between two picks, but should not matter that much otherwise. My experience: I got lucky with being given two Shogun’s Scepter, which are excellent spoils. I also secured a couple of Rakano Outlaw and Brightmace Paladin along with a few usable weapons. I did not manage to go all the way, losing game 4 to mana flood and then game 6 to a crazy series of plays by Vengeance. Still, one gold chest is good enough, especially when you’re lucky like me and it contains a Sparring Partner (another score !). First outing on the ladder! Congratulations on now having a semi decent deck ! It’s time for it to leave the nest now. Click that “ranked” button and battle away ! Don’t worry too much, it’s okay to lose. Maybe you’ll win some too, but even if you don’t you’ll certainly learn some things. Depending on the timing, you might find yourself in “unfair” match-ups with high ranked players rocking well tuned decks, so sweating over losses is really unnecessary. On the other hand, don’t just dismiss those losses as irrelevant either – note what’s killed you and what you maybe could have done better. My experience: The deck I was able to piece together for ladder looked like this: Baby’s First Rakano (example) This ragtag pile managed a very respectable 3-2 record, losing only to a very potent Stonescar curve-out and a Party Hour deck that looked like it belonged in Masters (or possibly in Nerf-land, but that’s another topic). First Draft After you completed your 5 placement games and collected your reward, you should have somewhere around 4,000 gold in the bank. You need 5,000 to buy your way into Draft, which is by far the most efficient way to grow your collection and also your next objective. I advise you to grind the last few gold coins you need in Gauntlet, as it’s an easier, less stressful environment to do so than the ranked ladder. It’s an opportunity to continue practicing with your deck too. Once that’s done, it’s time for you to discover one of the best things about Eternal: drafting! It’s a limited mode somewhat similar to Forge, but PvP, and actual packs being passed along (just like physical MtG drafting but asynchronous so you can take all the time you want) rather than 1-out-of-3 picks. Drafting is an art that is worth a whole series of guides on its own, and I’ll leave that to people more skilled at it than I am. Know that while that’s not always the best option, you can also “force” factions in draft. You can’t actually influence what cards you get passed, but you can decide to pick cards in the factions you want. That’s not always optimal for a bunch of reasons, most notably possible signals that someone up the line is already drafting the same factions, but we can choose to ignore those in the name of strategically advancing our collection. Note that Rakano is a strong choice for draft anyway, so you’re not gimping yourself much either. Just like with forge earlier, I invite you to peruse the previous table as a guideline. Prioritize picks on top of each category. Technically it would be better to use a draft specific picking guide (and you’re welcome to do that if you have one handy) but since we’re also trying to get cards for our deck the above will do just fine. There are however two things not in that table you should look out for : Legendaries or good rares(even off-color) : just pick those. You draft more cards than can fit in your deck, so you can afford to dedicate a pick to scoring a card you want for later. bombs and removal : (yes, BREAD) draft is often a slower format than constructed, so relatively high cost, high impact stuff will definitely win you games. Notably: rares like Rolant’s Honor Guard Silverwing Commander Fourth-Tree Elder Renegade Valkyrie Torch Vanquish Once your picks are done, take the best 28-29 cards out of there, add 16-17 sigils – assuming you went by the above, your curve should be low – and get out there! *Disclaimer : the above does not make a good replacement for a proper drafting guide ! Use one of those for your next run, or ask for help on the ever helpful Discord channel. My experience: It took me 2

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similar details: that they received exploratory calls to see if they would be immediately available to participate in the reboot, which was presented as “a new adventure.” They were told that some of the contestants from the previous cast would not return and that contestants would need to be available later this week, though it remains unclear when they would actually resume filming. They were asked to clear their schedules until the end of July and would be compensated $12,500 for the adventure — with the opportunity to earn more. Bachelor in Paradise returns later this summer on ABC./* -*- Mode: java; tab-width: 8; indent-tabs-mode: nil; c-basic-offset: 4 -*- * * ***** BEGIN LICENSE BLOCK ***** * Version: MPL 1.1/GPL 2.0 * * The contents of this file are subject to the Mozilla Public License Version * 1.1 (the "License"); you may not use this file except in compliance with * the License. You may obtain a copy of the License at * http://www.mozilla.org/MPL/ * * Software distributed under the License is distributed on an "AS IS" basis, * WITHOUT WARRANTY OF ANY KIND, either express or implied. See the License * for the specific language governing rights and limitations under the * License. * * The Original Code is Rhino code, released * May 6, 1999. * * The Initial Developer of the Original Code is * Netscape Communications Corporation. * Portions created by the Initial Developer are Copyright (C) 1997-1999 * the Initial Developer. All Rights Reserved. * * Contributor(s): * Norris Boyd * Igor Bukanov * Bob Jervis * Roger Lawrence * Steve Weiss * * Alternatively, the contents of this file may be used under the terms of * the GNU General Public License Version 2 or later (the "GPL"), in which * case the provisions of the GPL are applicable instead of those above. If * you wish to allow use of your version of this file only under the terms of * the GPL and not to allow others to use your version of this file under the * MPL, indicate your decision by deleting the provisions above and replacing * them with the notice and other provisions required by the GPL. If you do * not delete the provisions above, a recipient may use your version of this * file under either the MPL or the GPL. * * ***** END LICENSE BLOCK ***** */ // API class package org.mozilla.javascript; import java.lang.reflect.*; import java.util.Hashtable; import java.io.*; import org.mozilla.javascript.debug.DebuggableObject; /** * This is the default implementation of the Scriptable interface. This * class provides convenient default behavior that makes it easier to * define host objects. * * Various properties and methods of JavaScript objects can be conveniently * defined using methods of ScriptableObject. * * Classes extending ScriptableObject must define the getClassName method. * * @see org.mozilla.javascript.Scriptable * @author Norris Boyd */ public abstract class ScriptableObject implements Scriptable, Serializable, DebuggableObject, ConstProperties { /** * The empty property attribute. * * Used by getAttributes() and setAttributes(). * * @see org.mozilla.javascript.ScriptableObject#getAttributes(String) * @see org.mozilla.javascript.ScriptableObject#setAttributes(String, int) */ public static final int EMPTY = 0x00; /** * Property attribute indicating assignment to this property is ignored. * * @see org.mozilla.javascript.ScriptableObject * #put(String, Scriptable, Object) * @see org.mozilla.javascript.ScriptableObject#getAttributes(String) * @see org.mozilla.javascript.ScriptableObject#setAttributes(String, int) */ public static final int READONLY = 0x01; /** * Property attribute indicating property is not enumerated. * * Only enumerated properties will be returned by getIds(). * * @see org.mozilla.javascript.ScriptableObject#getIds() * @see org.mozilla.javascript.ScriptableObject#getAttributes(String) * @see org.mozilla.javascript.ScriptableObject#setAttributes(String, int) */ public static final int DONTENUM = 0x02; /** * Property attribute indicating property cannot be deleted. * * @see org.mozilla.javascript.ScriptableObject#delete(String) * @see org.mozilla.javascript.ScriptableObject#getAttributes(String) * @see org.mozilla.javascript.ScriptableObject#setAttributes(String, int) */ public static final int PERMANENT = 0x04; /** * Property attribute indicating that this is a const property that has not * been assigned yet. The first 'const' assignment to the property will * clear this bit. */ public static final int UNINITIALIZED_CONST = 0x08; public static final int CONST = PERMANENT|READONLY|UNINITIALIZED_CONST; /** * The prototype of this object. */ private Scriptable prototypeObject; /** * The parent scope of this object. */ private Scriptable parentScopeObject; private static final Slot REMOVED = new Slot(null, 0, READONLY); static { REMOVED.wasDeleted = 1; } private transient Slot[] slots; // If count >= 0, it gives number of keys or if count < 0, // it indicates sealed object where ~count gives number of keys private int count; // cache; may be removed for smaller memory footprint private transient Slot lastAccess = REMOVED; // associated values are not serialized private transient volatile Hashtable associatedValues; private static final int SLOT_QUERY = 1; private static final int SLOT_MODIFY = 2; private static final int SLOT_REMOVE = 3; private static final int SLOT_MODIFY_GETTER_SETTER = 4; private static final int SLOT_MODIFY_CONST = 5; private static class Slot implements Serializable { static final long serialVersionUID = -3539051633409902634L; String name; // This can change due to caching int indexOrHash; private volatile short attributes; transient volatile byte wasDeleted; volatile Object value; transient volatile Slot next; Slot(String name, int indexOrHash, int attributes) { this.name = name; this.indexOrHash = indexOrHash; this.attributes = (short)attributes; } private void readObject(ObjectInputStream in) throws IOException, ClassNotFoundException { in.defaultReadObject(); if (name != null) { indexOrHash = name.hashCode(); } } final int getAttributes() { return attributes; } final synchronized void setAttributes(int value) { checkValidAttributes(value); attributes = (short)value; } final void checkNotReadonly() { if ((attributes & READONLY) != 0) { String str = (name != null ? name : Integer.toString(indexOrHash)); throw Context.reportRuntimeError1("msg.modify.readonly", str); } } } private static final class GetterSlot extends Slot { static final long serialVersionUID = -4900574849788797588L; Object getter; Object setter; GetterSlot(String name, int indexOrHash, int attributes) { super(name, indexOrHash, attributes); } } static void checkValidAttributes(int attributes) { final int mask = READONLY | DONTENUM | PERMANENT | UNINITIALIZED_CONST; if ((attributes & ~mask) != 0) { throw new IllegalArgumentException(String.valueOf(attributes)); } } public ScriptableObject() { } public ScriptableObject(Scriptable scope, Scriptable prototype) { if (scope == null) throw new IllegalArgumentException(); parentScopeObject = scope; prototypeObject = prototype; } /** * Return the name of the class. *

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or you get material way, way beyond what you already know. It's like a bomb going off, where you have to work very hard, mentally and physically, to absorb what is being taught and to understand the point of view. Then you start thinking about it in the context of what you already know, and you start wondering if you're on the right path... and if you are, how things should be changed to fit the information you've just assimilated. Ultimately, you may or may not end up adopting whatever the "bomb" type seminar showed you, but it does, for a while, impact how you think about your own art. I think that's a good thing - I think we need this sort of challenge once in a while. I usually leave this sort of seminar physically tired but mentally completely fried. THE COAST This is the kind of seminar where you don't learn anything new. You might think this sort of thing is a waste of your time, but really, here's something you can do if you find yourself coasting. I like to use this sort of seminar to work on my instruction skills. If I already know the content, I try my best to make sure I pair up with people who are very new to all of this (for them, this is a "Bomb" session, after all). I am careful to try to show exactly what the teacher at the seminar is showing the way he or she is showing it. It's my opportunity to hone my instructor skills and help a new person feel more welcomed into my art. THE FINE TUNE This camp is where you work on what you already know but in a way where you understand it better. It's comfortable, like coasting, but it's also a challenge and you learn a lot, like the bomb going off. It's like rotating a famous sculpture to see a side you don't normally see, or reading an analysis of a favorite book that points out nuances you haven't noticed before. This is a really important kind of seminar. It's the kind of session where you move beyond the surface of what we're taught in the earlier stages of our training. I usually leave this sort of camp energized and feeling creative. Where did this material come from? Oh yeah, sensei went to a seminar... Are there other kinds of camps or seminars than what I've described? Let me know in the comments!Amidst the hyper-capitalist spectacle of Frieze 2018, the political turmoil of the last year, and on the day before Brett Kavanaugh’s controversial and much-contested confirmation, legendary photographer Nan Goldin took to the stage with veteran arts writer Linda Yablonsky to discuss her career. Goldin is famously one of the most fearless photographers of her generation – with work that examines the deeply nuanced relations between ‘coupling’ of all degrees. From relationships that veer between fear and obsession, to individuals in a complex relationship with their own self-presentation, Goldin’s work has always delved into the rich tapestry of our own humanity. Her appearance forced a re-consideration of her landmark practice, in the context of a modern world that though plagued with political unrest has at least made leaps and bounds in the context of queer representation – of which Goldin was a torch-bearer, realising the vast array of aesthetic and emotional identities that could be caught on camera under the focus of her lens. “The instance of photographing, instead of creating a distance, is a moment of clarity and emotional connection for me.” This was clear in each moment of her conversation with Yablonsky, who carefully guided the conversation through a cast of characters – many of whom are now historically renowned; Robert Mapplethorpe, David Wojnarowicz, Cookie Mueller, and other luminaries of New York on the cusp the AIDS epidemic, which would cut short so many of their brilliant lives. Writing on the iconography and rhetoric of the AIDS epidemic — and the “epidemic of signification” that occurred as result — Susan Sontag assessed that “the catastrophe of AIDS suggests the immediate necessity of limitation.” This accompanied, in part, the observation of multiple socio-cultural breakdowns; the conflation of medical fact and social fiction, the sensationalising impact of moral panic upon the media, the effect of hysteria upon imaging the disease — and how these were fuelled careless reporting, pre-existing homophobia, and governmental complacency. In a time of cultural confusion, ‘fake news’, and the breakdown of public discourse over multiple crises of socio-political injustice, Goldin’s work remains as relevant today as it has ever been. The talk began with Nan Goldin at Frieze 2018 highlighting to the audience the presence of a striking series of medicinal bottles on the table, one for each life that would be lost to the American Opioid crisis during the course of her one-hour talk. This is her latest cri de coeur, and one through which she has suffered directly (as has always been the case with her work.) Writing of her own struggle with opioid addiction, Goldin acknowledges she “narrowly escaped […] I went from the darkness and ran full speed into the world. “I was isolated, but I realised I wasn’t alone. When I got out of treatment I became absorbed in reports of addicts dropping dead from my drug, OxyContin. I decided to make the private public […] my first action is to publish personal photographs from my own history.” As such, she has led an international campaign against the Sackler family – prescription drug dynasty and noted patrons of the arts – described by the New York Times as “the family that built an empire of pain.” In again tying her work to an epidemic of physical injustice and its emotional consequence, Goldin continues to forge ahead with a photographic practice that is deeply entrenched in her own personal politics – and in the bravery it takes to make the personal public in the name of political progression. We should all be grateful for her fearlessness, and the humility and honesty with which she rages on. “Memories of childhood humanize us as adults. With age, our version of that time is deformed then reassembled. What fragments bleed through are tailored to a narrative designed to hide vulnerability.” -P.K., And Every Day Was Overcast If the absence of vulnerability is a hallmark of adult self-retrospection as the first three lines of Paul Kwiatkowski’s debut novel, And Every Day Was Overcast, suggests, then the candid recollections of book’s protagonist, P.K., certainly break the mold. The narrator’s willingness to cast aside vulnerability in the service of brute honesty is all too evident as he recounts the ten years of his youth spent in Loxahatchee, Florida during the 1990s. P.K.’s youthful exploits are told in such nerve-bearing detail that not much is left to the imagination. Take, for example, P.K.’s account of how he willingly exposed himself to a drifter to score alcohol for him and his friends. Another section of the book describes how P.K. witnessed an acquaintance commit a random act of cruel violence against the school outcast, then abandon the victim’s unconscious body outside a 7-Eleven. The friendless, unfortunate boy, named Cobain, is never to be seen or heard from again, leaving the P.K. to ruminate in remorse through the course of his young adult life. “Worse than my guilt and fear was the relief I felt” laments P.K. “I told myself that his evaporation was a small death that had brought him to a better place.” Yet another passage from the book describes the 40 hours of court-ordered community service P.K. spent under the wing of an HIV-positive ex-drag queen named Cody, who introduces him to the secret lives of supposedly straight, well-to-do yuppy men who cruise for sex in drive-in theater parking lots and dingy gas station bathrooms in their off-hours away from work and home. Such are the types of memories many would try to bury as far into the depths of their psyche as possible. Instead, they are brought to light by the narrator in a graphic novel that reads like a yearbook from one of the most dysfunctional high school experiences imaginable. Kwiatkowski’s Florida is more than just the sunny, resort-ladden getaway destination its tourism department would have one believe. Its magic and charm are certainly not lost on the author, though both take a form that is much less that of the Disney variety. The author admits it took him leaving the state to fully realize just how much Florida’s topography influenced his adolescent experiences, though he’d always had it in the back of his mind that the state functioned on a plane quite different from other places. “I grew closer to the Bahamas and Jamaica than I did Georgia” says Kwiatkowski, who is currently based in New York. “So I think when you grow up in that cultural landscape you’re aware that you’re a little bit distant from the rest of America.” Shows like America’s Most Wanted, which Kwiatkowski says never ceased to showcase Florida’s pedophiles, rapists and murders, only helped to validate the author’s suspicions about the Sunshine State. Narratives like the vignettes found in And Every Day Was Overcast have been told countless times. Kwiatkowski’s book calls to mind Larry Clark’s seminal film Kids (1995), which drove a slegde hammer into the whimsical, John Hughes

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members that left the games industry are working on films. Some are at tech companies like Google, Apple, and Tesla. A few have even worked as illustrators for children’s books. After Uncharted 2 shipped, Pope decided to go back to making the experimental games he got started with. He moved to Japan, closer to the family of his wife, fellow developer Keiko Ishizaka. In 2013, Pope released the critically-acclaimed Papers, Please. He has continued to make small games, and in 2018 put out Return of the Obra Dinn, which won grand prize at the Independent Game Festival Awards. A few Uncharted 2 staffers, like lead environmental artist Teagan Morrison, have left the games industry completely. Morrison, born in the UK, got his start making websites before moving to making 3D art and selling it online. Naughty Dog was a “dream job” for Morrison but he couldn’t legally work in the United States yet. The day his family got a green card, he sent in an application. After working constantly for two weeks on an environment test and going through interviews in which he was “sweating buckets,” Morrison was hired in 2006. After working as an environment artist on the first Uncharted, Morrison was made a lead for the sequel. He later became a lead technical artist, where he helped manage the vast amount of artists at Naughty Dog. Once Uncharted 4 released, Morrison decided to leave and help start Sky Castle Studios, which makes products like Hero Forge, a custom miniature service. Film and television have also attracted multiple people from Naughty Dog. Justin Richmond, game designer for Uncharted 2 and director of 3, co-founded the multi-media company Wonderstorm and co-created the Netflix show The Dragon Prince. Another person to go into film was concept artist Andrew Kim. Kim got his start working at game developer Pandemic in 2002, but jumped between films and games over the next few years. Near the end of his work as a concept artist on God of War 3, Kim’s friend Hong Ly told him Naughty Dog was hiring, and in 2008 he joined. After a few years, towards the end of development of Uncharted 3, another friend told him Marvel was looking for concept artists for its movies. “It was one of those opportunities I couldn’t resist,” he said. Kim worked as a senior concept artist for almost 3 years. After having a fourth child in 2014, Kim left and went freelance. Since then he has worked on various projects, including working as a freelancer on Uncharted 4, and on television shows like Star Trek: Discovery. While this article focused on Uncharted 2, these kinds of stories can be seen across the games industry. Thousands and thousands of people work hard to make the games we play, and every one has their own story. AdvertisementQ: Force linking against Python release library in debug mode in Windows/Visual Studio from CMake I'm developing a Python binding for a C++ library using Boost Python, for Linux and Windows (Visual Studio). In Windows, the static Boost Python library has a dependency against Python (this is motive for another thread, here), so, in my CMake config I need to do: if((${CMAKE_SYSTEM_NAME} STREQUAL "Linux") OR APPLE) target_link_libraries(my_python_module ${Boost_LIBRARIES}) elseif(WIN32 AND MSVC) add_definitions(/DBOOST_PYTHON_STATIC_LIB) target_link_libraries(my_python_module ${Boost_LIBRARIES}) #This includes the Boost Python library # Even though Boost Python library is included statically, in Windows it has a dependency to the Python library. target_link_libraries(my_python_module ${Python_LIBRARIES}) endif() This works fine in Linux, but in Windows, it only works in Release mode, not in Debug, in which case I always get a: LINK : fatal error LNK1104: Can't open file 'python37.lib' After some hair pulling I noticed the issue was caused by CMake instructing Visual Studio to link against 'python37_d.lib' instead of 'python37.lib' in the Debug mode. However, as I described in the linked issue, the officially provided Boost Python debug library is linked against the Python release library, not the debug one. So, the solution would be to force the link against the Python release library, regardless of the build type. Unfortunately, ${Python_LIBRARIES} sets the library automatically depending on the mode, and I wouldn't like to explicitly specify python37.lib in my code (since I can upgrade Python and I don't want to have to change my CMake scripts because of that). I found some similar issues here and here, but that doesn't reflect the exact situation I'm facing. Based on those, I tried setting: target_link_libraries(my_python_module optimized ${Python_LIBRARIES}) But that didn't work either. So, the question is: Is there a way to force the usage of the Python release library in Debug mode WITHOUT having to set it explicitly and leaving the Python CMake package to do it automatically instead. By explicit I mean doing: target_link_libraries(my_python_module python37) Thanks a lot for your help. A: It seems that set(Python_FIND_ABI "OFF" "ANY" "ANY") as suggested in the comments by kanstar would be the correct way to do this. However, while Python_FIND_ABI is in CMake master, it hasn't been released yet in the latest version (v3.15.2 as of this writing). In the meantime, there are solutions dependent on the CMake version. CMake 3.12 and above It's possible to link against FindPython's Python_LIBRARY_RELEASE, which isn't meant to be part of the module's public interface, but the variable is set correctly nonetheless. cmake_minimum_required (VERSION 3.12) find_package(Python ..<choose your COMPONENTS; refer to FindPython docs>..) if(WIN32 AND MSVC) target_link_libraries(my_python_module ${Python_LIBRARY_RELEASE}) endif() CMake 3.0.4 to 3.11 Thanks to a comment by @Phil, we can expand the answer to include earlier CMake versions which had the FindPythonLibs module that sets the PYTHON_LIBRARY_RELEASE variable instead. cmake_minimum_required (VERSION 3.0) find_package(PythonLibs ..<refer to FindPythonLibs docs>..) if(WIN32 AND MSVC) target_link_libraries(my_python_module ${PYTHON_LIBRARY_RELEASE}) endif() using System; using System.Collections.Generic; using System.Diagnostics; using System.Linq; using System.Text; using System.Threading.Tasks; using Xamarin.Forms; using Xamarin.Forms.CustomAttributes; using Xamarin.Forms.Internals; using Xamarin.Forms.Xaml; #if UITEST using Xamarin.Forms.Core.UITests; using Xamarin.UITest; using NUnit.Framework; #endif namespace Xamarin.Forms.Controls.Issues { #if UITEST [Category(UITestCategories.InputTransparent)] [Category(UITestCategories.Gestures)] [NUnit.Framework.Category(Core.UITests.UITestCategories.Github5000)] #endif [Preserve(AllMembers = true)] [Issue(IssueTracker.Github, 2858, "Transparency Cascading", PlatformAffected.Android)] public partial class Issue2858 : TestContentPage { const string Success = "Success"; const string Failure = "Fail"; const string InnerGrid = "InnerGrid"; const string OuterGrid = "OuterGrid"; #pragma warning disable CS0414 int _tapCount = 0; #pragma warning restore CS0414 public Issue2858 () { #if APP InitializeComponent (); #endif } #if APP void TapGestureRecognizer_OnTapped(object sender, EventArgs e) { _tapCount += 1; if (_tapCount == 1) { Result.Text = Success; } else { Result.Text = Failure; } } #endif protected override void Init() { } #if UITEST [Test] public void CascadeInputTransparentGrids() { RunningApp.WaitForElement(InnerGrid); RunningApp.Tap(InnerGrid); var green = RunningApp.WaitForElement(OuterGrid); RunningApp.TapCoordinates(green[0].Rect.CenterX, green[0].Rect.Y + 20); RunningApp.

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s. From the above verse it is substantiated that is nothing but due to illiteracy and ‘knowledgelesness’ of Qur’aan and Hadith. If Allah (Jal…) is conversing with a person it should be understood that He is Waliyullah. Allah (Jal…) has conversed with Imam Shazuli (Razi…) several times through (Ilhaam) mind. Shazzan Lee Named by Allah:Once Hazrath Imam Shazuli (Razi…) was giving lecture to his followers and people at Shazila. A lot of muridheens were gathered around him awaiting for the words which would come out from Imam.Imam’s speech was like the water coming out of a opened sluice. Imam Shazuli (Razi…) was telling about Allah (Jal…)’s favour towards us, our duty towards Allah (Jal…), our gratitude to be shown towards him and the relationship between the universal creator Allah (Jal…) and his human creations. Listening all this from the Imam the people felt as if they were standing before Allah (Jal…). Hazrath Imam Shazuli (Razi…) who gave speech with calmness heard a voice “Antha Shazzan – Lee”. Feeling that this voice is from Allah’s side, Shazuli Imam (Razi…) asked “Ya Allah! I am not from Shazila and then why am I called Shazuli”? “You are my most lovable”. You are with individuality and you are superior among my affectionate and hence the name (Shazzan Lee) replied Allah (Jal…). The number of muslims following Hazrath Imam Shazuli (Razi…) increased day by day. There were 125 thousand followers of Imam when he entered the Cairo city. From this we can know the integrity of Hazrath Sheikh Shazuli (Razi…). Hazrath Imam Shazuli (Razi…) built a madarasa by name “AL MADRASATUL KAMILIYYA” at Cairo city where AL – AZHAR UNIVERSTY is situated today. The knowledge of Imam Shazuli (Razi…) was explainable to the Malayikaths. Once, Imam Shazuli(Razi…) was traveling with Hazrath Abu Muhammadh Abdhullah Al Hasani (Razi…) towards a city Shazila. On the way Imam said “Oh Abu Muhammadh! you be standing there at that point you need not come in search of me”. Few minutes later Imam Shazuli(Razi…) felt uneasy, and he left his friend Hazrath Abdhullah . Suddenly some four large birds came down. That formed a queue and talked something with Imam one by one with reverence. Then a plethora of tiny birds came down and surrounded Imam. Later they all flied off.Imam asked “Oh! Abdhullah! Did you see any wonder?” Yes my Sheikh! I replied and briefed to Sheikh what I saw, and asked for its meaning.Imam replied “The four large birds were the Celestial beings (Malaks). They had a doubt and came to me for explanation and they returned with satisfaction”. The numbers of tiny birds were the soul of Waliyullahs who want to get prosperity by visiting me. Preceptor of Siddiqeens:-Allah (Jal…) ordered Imam Shazuli (Razi…) to go to Cairo to train up some 40 Siddiqeens spiritually. Imam too went and gave those Siddiqeens who are next to Nabis good advices. “An amallahu alaihim minan Nabiyeena Was Siddiqeena wash Shuhadhayi was Sualiheen”. “Whoever follows Allah and his Prophet, will be with those like Nabis (Messengers), Siddiqeens,Shuhadhaas and Sualiheens.Upon him Allah’s mercy is blessed, on the day of judgement. In this order it is found that Siddiqeens are prior to Shuhadhaas (Martyrs who were killed for the sake of Islam) from the above verse. Imam Shazuli (Razi…) had been a teacher to that kind of Siddiqeens! Subhaanallah! Shariath – bridle for foretelling – instance about Sheikh Shamsudheen Hanafi (Razi…):-“If the bridle called Shariath is not locked upon my mouth, I would tell you all, what is to happen till the day of Qiyamah” said the ocean of knowledge Hazrath Imam Shazuli (Razi…). But to prove this his statement He foretold an incident to his followers about the birth of Sheikh Shamsudheen Hanafi (Razi…). Talking to a big gathering at the Cairo city, Imam Shazuli (Razi…) lectured “Oh my people! Listen carefully to what I am conveying today. Exactly 100 years after me, a male child will originate at Egypt. He will be Reddish white in colour. There will be a mole at his right cheek which will beautify him. He will lose his parents at his early stage and his name is “Muhammadh” He will be called “Shamsudheen”, He will be a follower of Hanafi School. He will rejuvenate “Zaviya” my madarasa. This tariqa will be spread all over the world during his tenure as 5th Khaleefa of mine. His praise & familiarity will grow high”. Just as Imam Shazuli (Razi…) had foresaid, everything happened. People wondered and they felt proud about this incident, feeling Shazuli Imam (Razi…) as the real panacea of ever.Introducing coffee to the world:-During his earlier period Imam Shazuli (Razi…) had firm meditation at the Saffron hill. He spent 40 days fasting and 40 nights on prayers. Floral leaves and salt was the only food both for Sahar & Iftar. Sometimes Imam felt very tiresome and he was thinking about how to overcome this? At that time Allah (Jal…) showed coffee to Imam through some birds. Those tiny birds wandering during day time were praying and begging God at the night. But they were brisk anytime. Making note of this Imam Shazuli (Razi…) was very much surprised. He saw those birds sitting at a tree and taking some seeds. After eating the seeds,the birds were refreshed. Suddenly Imam collected those seeds and put it to the water and drank. What a surprise! All his exhausted-ness flied off and Imam Shazuli (Razi…) was fully brisk and refreshed. Historians write that was the first invention of coffee till today and we are using it similarly. So the pride of introducing coffee a good refresher goes to Imam Shazuli (Razi…).Zikr Jahri:-When Imam Shazuli (Razi…) was at the Zawiya of Cairo he introduced the open meditation. Sheikhs of other tariqas introduced a silent way of meditating God. Unlike other Sheikhs Imam Shazuli (Razi…) preached Zikr Jahri and there is an incident behind this. Hazrath Abu Muhammadh Abdullah who was there along with Imam while Sheikh Shazuli Imam (Razi…) was on firm meditation at the saffron hill for 40 days, narrates:I stayed there at the cave of saffron hill with Sheikh Shazuli Imam (Razi…) for 40 days. I could feel the rain of mercy of Allah (Jal…) lashing on Imam Shazuli (Razi…).”Man Kaanallahu kaana lahu kulli shaiyin”, “If a person turns himself for Allah, every matter turns for him”. As Hazrath Imam Shazuli (Razi…) was affectionate towards Allah (Jal…), according to the above Hadith, Allah made everything to turn to our Sheikh’s possession. One day during midnight after praying Tahajjudh, Hazrath Shazuli Imam was reciting Qur’aan. He was reciting surathul An’aam. When he crossed a verse “Wa in tha’dhil kulla Adhlil laa yookhaz minha” means “If Allah were to go ahead to punish all human for their misdeeds, then none will survive. But Allah (Jal…) deals with them with leniency and not catches hold his slaves (Human)”. Hazrath Shazuli Imam (Razi…) was very much joyous feeling the mercy of Allah (Jal…) and so he repeatedly recited the same verse. And his lips started pronouncing “Allah… Allah… Allah…” and as he entered a state of (Jazb) his voice grew and was in the high pitch to the extent the entire mountain shook in the direction his Holy body moved in Jazb. As Hazrath was moving up and down and at the sides, the mountain also moved vertically and horizontally the same way. This situation lasted for a while. Who ever heard that were attracted towards it

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untos. The access to the career of Public Ministry magistrate obeys to the same previous conditions as the access to the careers of judges, also implying the graduation in the Centro de Estudos Judiciários. Barristers and solicitors The barristers (advogados) and solicitors (solicitadores) are the legal practitioners who represent the natural and legal persons before the courts and deal with other legal matters. The legal representation by a barrister is considered an essential element in the administration of Justice and is admissible in any proceedings. It can not be prevented before any jurisdiction, authority, or public or private entity. Both the professions of barrister and solicitor are statutory regulated and represented by public professional associations, respectively the Ordem dos Advogados (Order of the Barristers) and the Câmara dos Solicitadores (Chamber of the Solicitors). Being member of those professional associations is a mandatory condition for the practice of the professions of barrister or solicitor. The admission to the professional associations implies the previous graduation in Law (or alternatively having a solicitor's degree in the case of solicitors candidates), performing an internship and passing in access examinations. Officers of Justice The officers of Justice constitute the special class of public servants that serve in the secretaries of the courts and of the Public Ministry offices. Their roles include the providing of the administrative services of the Judiciary, the execution of warrants, the service of scrivener in the trials and the function of criminal police in the inquiries. The career of officer of Justice of the courts includes the categories of escrivão de direito (scrivener of Law), escrivão-adjunto (deputy scrivener) and escrivão auxiliar (auxiliary scrivener). Regarding the career of officer of Justice of the Public Ministry, it includes the categories of técnico de Justiça principal (principal technician of Justice), técnico de Justiça-adjunto (deputy technician of Justice) and técnico de Justiça auxiliar (auxiliary technician of Justice). See also Public Ministry Law of Portugal Judicial Studies Center Judiciary of Brazil Judiciary of Macau References * Court systemQ: Dataset is 20X slow when adding column heads I'm trying to use Dataset to explore some large data. I notice that the performance decrease more than 20X by adding heads to the columns. Here is an example: We generate some data with integers data = RandomInteger[{1, 100000}, {1000000, 7}]; convert it into a Dataset object ds1 = Dataset[data]; // AbsoluteTiming (* {0.000606, Null} *) and sort it according to the first column ds1[SortBy[#[[1]] &]]; // AbsoluteTiming (* {0.507638, Null} *) Now if we add the heads to the data head = "x" <> ToString[#] & /@ Range[7] (* {"x1", "x2", "x3", "x4", "x5", "x6", "x7"} *) ds2 = Dataset[AssociationThread[head -> #] & /@ data]; // AbsoluteTiming (* {4.57311, Null} *) Now sorting becomes 20X slower ds2[SortBy[#x1 &]]; // AbsoluteTiming (* {10.6259, Null} *) So why does the performance decrease when we add a header to our data? Is there a way to fix that? System information: version 11.1 on mac os 10.12.3 A: Your ds2 is a highly inefficient shape. Using 10 in place of 1000000 in the data code we get something like: (Observations made in Mathematica 10.1) ds2 // InputForm Dataset[{<|"x1" -> 10, "x2" -> 4, "x3" -> 8, "x4" -> 3, "x5" -> 6, "x6" -> 5, "x7" -> 5|>, <|"x1" -> 2, "x2" -> 9, "x3" -> 6, "x4" -> 10, "x5" -> 10, "x6" -> 5, "x7" -> 1|>, <|"x1" -> 9, "x2" -> 6, "x3" -> 6, "x4" -> 10, "x5" -> 2, "x6" -> 10, "x7" -> 6|>, <|"x1" -> 8, "x2" -> 2, "x3" -> 2, "x4" -> 2, "x5" -> 6, "x6" -> 2, "x7" -> 8|>, <|"x1" -> 1, "x2" -> 8, "x3" -> 10, "x4" -> 3, "x5" -> 8, "x6" -> 3, "x7" -> 9|>, <|"x1" -> 3, "x2" -> 6, "x3" -> 1, "x4" -> 10, "x5" -> 3, "x6" -> 5, "x7" -> 8|>, <|"x1" -> 6, "x2" -> 7, "x3" -> 5, "x4" -> 2, "x5" -> 10, "x6" -> 4, "x7" -> 9|>, <|"x1" -> 7, "x2" -> 10, "x3" -> 8, "x4" -> 1, "x5" -> 3, "x6" -> 3, "x7" -> 8|>, <|"x1" -> 4, "x2" -> 3, "x3" -> 6, "x4" -> 1, "x5" -> 8, "x6" -> 5, "x7" -> 1|>, <|"x1" -> 8, "x2" -> 7, "x3" -> 8, "x4" -> 1, "x5" -> 3, "x6" -> 9, "x7" -> 10|>}, TypeSystem`Vector[ TypeSystem`Struct[{"x1", "x2", "x3", "x4", "x5", "x6", "x7"}, {TypeSystem`Atom[Integer], TypeSystem`Atom[Integer], TypeSystem`Atom[Integer], TypeSystem`Atom[Integer], TypeSystem`Atom[Integer], TypeSystem`Atom[Integer], TypeSystem`Atom[Integer]}], 10], <|"ID" -> 127397422492264|>] Not only is this redundant but its form prohibits packing; every Integer is stored separately. Compare the Transpose of your ds2: ds2\[Transpose] // InputForm Dataset[<|"x1" -> {10, 2, 9, 8, 1, 3, 6, 7, 4, 8}, "x2" -> {4, 9, 6, 2, 8, 6, 7, 10, 3, 7}, "x3" -> {8, 6, 6, 2, 10, 1, 5, 8, 6, 8}, "x4" -> {3, 10, 10, 2, 3, 10, 2, 1, 1, 1}, "x5" -> {6, 10, 2, 6, 8, 3, 10, 3, 8, 3}, "x6" -> {5, 5, 10, 2, 3, 5, 4, 3, 5, 9}, "x7" -> {5, 1, 6, 8, 9, 8, 9, 8, 1, 10}|>, TypeSystem`Struct[{"x1", "x2", "x3", "x4", "x5", "x6", "x7"}, {TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10], TypeSystem`Vector[TypeSystem`Atom[Integer], 10]}], <|"Origin" -> HoldComplete[AssociationTranspose, Dataset`DatasetHandle[127397422492264]]|>] Observe that not only is the representation more compact but the data is typed as vector arrays: TypeSystem`Vector[TypeSystem`Atom[Integer], 10]. Create your Dataset in the efficient shape to begin with to avoid a very slow Transpose operation: ds3 = Dataset @ AssociationThread[head -> (data\[Transpose])]; From here you can quickly apply a sort like this: ds3[[All,

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"signers":[{ "name":"signer1", "type":"pkcs12", "algorithms":["SHA256withRSA"], "caCerts":[], "key":"password=1234,keystore=file:keycerts/ocsp1.p12" }], "stores":[{ "name":"store1", "ignoreExpiredCert":true, "ignoreNotYetValidCert":true, "includeArchiveCutoff":true, "includeCrlId":false, "retentionInterval":-1, "minNextUpdatePeriod":"1d", "unknownCertBehaviour":"malformedRequest", "updateInterval":"10m", "source":{ "datasource":"datasource1", "type":"ejbca-db", "conf":{ } } }] } Effects of residual novaluron on reproduction in alfalfa leafcutting bees, Megachile rotundata F. (Megachilidae). The chitin synthesis inhibitor novaluron can suppress pests that affect alfalfa seed production, but can negatively affect reproductive success in the alfalfa pollinator Megachile rotundata. Novaluron is considered to be a reduced-risk insecticide because it disrupts ecdysis and is non-lethal to adult insects, but some exposed adults have fewer eggs and suppressed egg hatch. For this experiment, bees nested in field cages where they were exposed to alfalfa that had never been treated with novaluron, alfalfa that had recently been sprayed or alfalfa that had been sprayed 1 and 2 weeks earlier. Compared with the control, greater proportions of dead eggs and larvae and lower proportions of live prepupae occurred when bees were exposed to recent novaluron sprays as well as one- or two-week old spray residues. Two possible routes of residual pesticide exposure were revealed. Mother bees become contaminated through ingestion or direct contact, or pollen-nectar provisions become contaminated with novaluron (1) on or within leaf pieces that surround provisions or (2) transferred from mother bees' bodies to provisions. We found strong immature mortality effects of novaluron and its residues on M. rotundata. Understanding all possible pesticide exposure routes for pollinating bees enhances decision-making for maintaining bee populations while protecting crops. © 2016 Society of Chemical Industry.// Copyright 2013 The Chromium Authors. All rights reserved. // Use of this source code is governed by a BSD-style license that can be // found in the LICENSE file. #include "extensions/browser/api/system_cpu/cpu_info_provider.h" #include "extensions/shell/test/shell_apitest.h" namespace extensions { using api::system_cpu::CpuInfo; class MockCpuInfoProviderImpl : public CpuInfoProvider { public: MockCpuInfoProviderImpl() {} bool QueryInfo() override { info_.num_of_processors = 4; info_.arch_name = "x86"; info_.model_name = "unknown"; info_.features.clear(); info_.features.push_back("mmx"); info_.features.push_back("avx"); info_.processors.clear(); info_.processors.push_back(api::system_cpu::ProcessorInfo()); info_.processors[0].usage.kernel = 1; info_.processors[0].usage.user = 2; info_.processors[0].usage.idle = 3; info_.processors[0].usage.total = 6; return true; } private: ~MockCpuInfoProviderImpl() override {} }; class SystemCpuApiTest : public ShellApiTest { public: SystemCpuApiTest() {} ~SystemCpuApiTest() override {} void SetUpInProcessBrowserTestFixture() override { ShellApiTest::SetUpInProcessBrowserTestFixture(); } }; IN_PROC_BROWSER_TEST_F(SystemCpuApiTest, Cpu) { CpuInfoProvider* provider = new MockCpuInfoProviderImpl(); // The provider is owned by the single CpuInfoProvider instance. CpuInfoProvider::InitializeForTesting(provider); ASSERT_TRUE(RunAppTest("system/cpu")) << message_; } } // namespace extensions 26 F.3d 123 State Bank of India, New York Branchv.Personal Data Systems, Inc., On-Line Solutions, Inc., Brody(Steven), Szegda (Michael) v. Szegda (Michael),Rosen, Szegda, Preminger & Bloom NO. 93-1767 United States Court of Appeals,Third Circuit. Apr 14, 1994 Appeal From: E.D.Pa., Newcomer, J. 1 AFFIRMED. I support a supreme law, written constitution for Aotearoa New Zealand. The main reason for this is my view that human rights need significantly more legal protection in our country. In their book, A Constitution for Aotearoa New Zealand, Sir Geoffrey and Dr Butler refer to the vulnerability of New Zealand’s human rights law, which may be overridden by a bare Parliamentary majority.1 They also refer to the power of New Zealand’s Human Rights Review Tribunal to declare that a law is inconsistent with the human right to be free from discrimination. As they say, however, even when the Human Rights Review Tribunal makes this type of declaration, Parliament can decide not to change the offending law.2 One of the Human Rights Review Tribunal cases they refer to is Adoption Action Incorporated v Attorney-General.3 I think this case exemplifies why our current legal protections for human rights are insufficient, and why truly constitutional guarantees are necessary. Adoption Action Incorporated advocates for adoption law reform.4 After “years of unsuccessfully lobbying various ministers and government administrations”,5 on 22 July 2011 Adoption Action brought its case in the Tribunal. This was “a last resort to bring about change to the adoption law of New Zealand.”6 Adoption Action claimed that sections of the Adoption Act 1955 and the Adult Adoption Information Act 1985 breached the right to freedom from discrimination on the grounds of sex, marital status, sexual orientation, disability, age, and race. The Tribunal heard the case over a total of 10 days, in late 2013 and in early 2014. Over 2 years later, on 7 March 2016, the Tribunal issued its decision.7 It upheld almost all of Adoption Action’s claims, and declared that six sections of the Adoption Act, and one section of the Adult Adoption Information Act, were inconsistent with the right to freedom from discrimination. The Government could have appealed the Tribunal’s decision, but it did not. Accordingly, the Government had to bring the Tribunal’s declarations to the attention of the House of Representatives, and advise the House of its response to the declarations.8 As set out in the Human Rights Act, the Tribunal’s declarations did not affect the legal validity of the sections of the Adoption Act and Adult Adoption Information Act found to be in breach of the right to freedom from discrimination.9 Any change would have to be made by Parliament. In August 2016, the Minister of Justice Amy Adams tabled the Government’s response to the declarations in the House.10 The Minister advised that the Government did not agree with two of the Tribunal’s declarations, for reasons which had been considered and rejected by the Tribunal in its decision. There was no reference in the response to the five other declarations made by the Tribunal, other than recording that they had been made. The response stated that reforming the Adoption Act would require “significant resource reallocation”11 and referred to Government’s other legislative priorities. Nothing was said about the Adult Adoption Information Act. The response also stated the Government’s view that the Adoption Act is, in practice, interpreted in a rights-consistent manner. This was despite the Government having conceded before the Tribunal that any such practice does not make discriminatory law non-discriminatory.12 The response further advised that the Government will not, “at the present time”,13 rectify the ongoing breaches of fundamental human rights identified by Adoption Action and upheld by the Tribunal. This outcome shows how fragile New Zealand’s domestic human rights framework is. Under it, the Government may ignore declarations made by the statutory body Parliament has empowered to determine whether legislation breaches the human right to freedom from discrimination. The Government may do this after years of hard-fought litigation, which it has lost, in reliance on arguments which failed in that litigation. Despite a fundamental human right being at stake, there is no requirement for the House of Representatives to vote on what should be done, or even to debate it. And where to now for Adoption Action, or people affected by the discrimination? There is no point in going back to a New Zealand court, as Adoption Action won in the Tribunal. A petition could be taken to the United Nations Human Rights Committee, but the Government could ignore any outcome from that process too. That leaves a return to lobbying, which Adoption Action had tried for decades previously, without success.

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doing it wrong? Is the tutorial / instruction mistaken? <OerHeks> maybe you need unity-tweak-tool for that, not sure <OerHeks> dbugger, ^^. as the system seetting do give themes, but not icon themes seperate <ycyclist> update-alternatives --set java /usr/local/java/jdk1.8.0_91/jre/bin/java update-alternatives: error: no alternatives for java <saitoh183_> im having a issue importing a 28mb db using phpmyadmin <saitoh183_> http://paste.ubuntu.com/19277184/ <saitoh183_> just get a blank page <joelio> saitoh183_: do you have php max size set or something in php.ini? <joelio> oh, that looks like an actual failure <Jack543> Hello! <soulez> Where in launchpad.net can I request a petition to add a feature in ubiquity installer to make possible install ubuntu in a preencrypted hard disk out of the box like fedora or centos installer, it is a very usefull option <saitoh183_> joelio: yes <dbugger> So I cant set the icons, with Unity? <saitoh183_> joelio: http://paste.ubuntu.com/19278449/ <xangua> dbugger: install unity tweak tool as you were told <dbugger> oh i have it already. let me see <dbugger> Indeed that did it <dbugger> thanks you! <joelio> saitoh183_: not fastcgi timeouts too.. php one part, but perhaps another part has timeouts set too <joelio> looks like it's being disrupted during load <joelio> but that could also be SQL that's making the parser b0rk <joelio> saitoh183_: have you managed to ingest that dataset ok locally <joelio> also, what's wrong with a <joelio> mysql -u blah -p < file.sql ? <joelio> (assuming cli access) <andrzej> joelio: if not CLI he can use this https://www.adminer.org/ one php file with mysql admin <Jack543> Hello! <Jack543> Developer C? <saitoh183_> joelio: i didnt try via CLI but i could <Pici> Jack543: if you're asking about programming in C, the channel is ##C <joelio> saitoh183_: yea, cli all the way, always going to be quicker than using http and interpretted languages to load mysql <saitoh183_> joelio: what would be the proper command? My sql file is in my home folder <joelio> mysql -u {username in database } -p < {path to mysql file} <joelio> the -p prompts for password <paranoidabhi> hi <joelio> the < is a shell redicrection <paranoidabhi> questoin: http://askubuntu.com/questions/795169/kde-slow-boot-on-kubuntu-16-04 <paranoidabhi> *question <paranoidabhi> please have a look. :) <paranoidabhi> I have posted it several times. <joelio> a 5400rpm HD isn't the quicket you know... <paranoidabhi> joelio, yeah but 2:30 is still way long <saitoh183_> joelio: ERROR 1046 (3D000) at line 29: No database selected do i have to create a empty db? <paranoidabhi> joelio, windows on dual boot takes 45 secs. <joelio> saitoh183_: ok, so add the db <joelio> mysql -u blah -p {database} < file.sql <Powerless> i am trying to send this line and it says connection refused. how to allow it? echo "test" | ssh walluser@IP wall <paranoidabhi> I can't find anyway to fix it. I very tired finding solutions. Please suggest any relevant directions. <joelio> paranoidabhi: have you tried adding that module you say is faully (wifi or ethernet?) to a blacklist and see if it boots quicker <paranoidabhi> joelio, thanks for the suggestion. I haven't, can you suggest how I can do that. <joelio> paranoidabhi: yea, just checking for 16.04.. normall it's in /etc/modprobe.d/blacklist <tahder> good morning, I'm installing ubuntu 16.04 LTS on my lenovo desktop. I'm currently stuck on the partitioning table.I have 16004 MG of free space and i can't seem to get it right. i divide the space up as follows: 7967mb ext4,primary,beg, mount / : 34 efi,logical,beg : 8002 swap,logical,beg. And it keeps switching between errors of: root system not defined, swap area failed, or efi boot needs to be defined (that was before I added <tahder> it. Any help would be much appreciated <joelio> paranoidabhi: yea, /etc/modprobe.d/blacklist is where you can put it 'blacklist r8169' and give that a try <joelio> you won't get any nic - but at least if it goes quick, then you know why it's slwo booting <joelio> and bet a usb nic for cheap if you need or something <saitoh183_> joelio:will i need a new db <paranoidabhi> joelio, is it blacklist.conf in 16.04? <joelio> saitoh183_: well if your SQL doesn't have a CREATE DB func at the top <joelio> yes, also, check the user has perms to create the db.. but just use the same credentials as what you were useing <joelio> that should be fine <joelio> paranoidabhi: I think so, yea, look inside it and check <joelio> paranoidabhi: tbh I don't that that will be it <joelio> as that dmesg spam looks like it runs at all times <joelio> but not my machine :) <paranoidabhi> joelio, the spam occurs on disconnecting the ethernet cable not always. <dutchie> Hi, I'm having some trouble with a custom PAM module I've put into /lib/x86_64-linux-gnu/security (where all the other PAM modules are). auth.log seems to indicate that it's looking in /lib/security, but that doesn't even exist. Do I need to do more than just dropping my .so in place? <dutchie> (this is on 14.04) <gnumonk> Hi <gnumonk> what is the "cgroup 7.7G 0 7.7G 0% /sys/fs/cgroup" in df -kh output <nacc> gnumonk: cgroup filesystem https://www.kernel.org/doc/Documentation/cgroup-v1/cgroups.txt <nacc> gnumonk: it's a virtual file system (like /proc and /sys) <anddam> is there a way to have usb devices belonging to a specific group the same way block devices belong to group disk? <c0ax> Hello there, can someone help me? <gnumonk> nacc: ok its had actully reserved 7.7 GB disk space? <nacc> gnumonk: no <sahil> hello <DJones> c0ax: Ask your question in the channel, until you do that, people won't know if they can help <ducasse> anddam: i guess you could set up a udev rule <nacc> gnumonk: i'm guessing it will look similar to the other tmpfs filesystems in size <gnumonk> nacc: So I have confusion here, lsblk shows hard disk size let say "100GB" but df -kh shows 84G, where 7 GB for tmpfs and 7GB for cgroups. <sahil> i am running ubuntu gnome based on ubuntu 13.10.i would like to know to to upgrade it to latest version. thanks <c0ax> I have problem with my ubuntu 16.04. Ive installed openssh clinet/server and netstat -tulpn says that 22 is running ive added rule to the iptables also ufw allow 22. But im not able to connect to it from other computer on the SAME network. I can ping it, but cant connect <gnumonk> sahil: upgrade to 14.04 first

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stein_J_Org_Chem-14-2229-g008){#C1} A mechanism that leads to the formation of diaminated pyrrole adduct **7** starts with amine-induced formation of a 1,4-dialdehyde, which then undergoes Paal--Knorr pyrrole formation to give an azafulvinium intermediate ([Scheme 2](#C2){ref-type="fig"}). This intermediate could then undergo trapping with an additional mole of amine nucleophile to give **7** as a mixture of diastereomers. ![Proposed mechanism for formation of onchidal diaminated adducts.](Beilstein_J_Org_Chem-14-2229-g009){#C2} In an effort to reduce the complexity of the NMR spectra observed for the diastereomeric onchidal--pyrrole adducts, a range of simpler achiral *n*-pentyl **11**--**14** and cyclohexylmethyl **15**--**18** side-chained model compounds, as either the dialdehyde or masked dialdehyde variants, were prepared ([Fig. 2](#F2){ref-type="fig"}). ![Target onchidal model compounds **11**--**18**.](Beilstein_J_Org_Chem-14-2229-g003){#F2} Horner--Wadsworth--Emmons (H.W.E.) reaction of *n*-hexanal with phosphonoester **19** \[[@R15]\] afforded an *E*/*Z* mixture of olefinic diesters, purification of which by silica gel column chromatography afforded a fraction of the desired *E* diester **20** (60%), a second fraction comprised of a 5:1 *E*/*Z* mixture and a third fraction of *Z* diester **21** (10%, [Scheme 3](#C3){ref-type="fig"}). The reduction of diesters **20** (*E*) and **21** (*Z*) with LiAlH~4~ afforded diols **22** and **23** in 63% and 67% yield, respectively. Subsequent oxidation of **22** with DMP afforded dialdehyde **11** in 31% yield. Correspondingly, the reaction of diol **23** with DMP afforded a mixture of dialdehyde **11** with dialdehyde **12** (1:1). Attempts at chromatographic separation of these two isomers resulted in degradation of **12**. Final conversion of **11** to enol acetate **13** was achieved by overnight reaction with pyridine and acetic anhydride. Purification by silica gel column chromatography afforded the desired *E,E* enol acetate **13** in 17% yield. A lack of purified dialdehyde **12** prevented any attempt at the preparation of enolacetate **14**. ![Synthesis of *n*-pentyl dialdehydes **11** and **12** and enol acetate **13**. Reagents and conditions: a) *n*-hexanal (0.8 equiv), LiOH·H~2~O (1.2 equiv), THF, 4 h, 60% (**20**), 10% (**21**); b) LiAlH~4~ (2.5 equiv), Et~2~O, 0 °C, 1 h, 63% (**22**), 67% (**23**); c) DMP (2.5 equiv), CH~2~Cl~2~, 4 h, 31% (**11**); d) Ac~2~O (2 equiv), pyridine (4 equiv), overnight, 17% (**13**).](Beilstein_J_Org_Chem-14-2229-g010){#C3} Having developed a successful synthetic route to *n*-pentyl side-chain dialdehyde **11** and enol acetate **13**, the synthesis of analogues **15**--**18** with a side-chain more comparable to onchidal (**6**) were attempted. H.W.E reaction of 2-cyclohexylacetaldehyde (**24**) \[[@R16]\] with phosphonoester **19** afforded a fraction of the desired *E* diester **25** in 15% yield, a fraction of *Z* diester **26** in 1.5% yield and another fraction of a mixture of the two (5:1) ([Scheme 4](#C4){ref-type="fig"}). The reaction of diesters **25** and **26** with LiAlH~4~ afforded the corresponding diols **27** and **28** in 61% and 71% yield, respectively, which upon oxidation (DMP) afforded dialdehydes **15** and **16** in 49% and 73% yield, respectively. The reaction of dialdehyde **15** with Ac~2~O and pyridine afforded enol acetate **17** in 43% yield after purification. Interestingly, the reaction of dialdehyde **16** with Ac~2~O/pyridine only afforded decomposition products, failing to give **18**. ![Synthesis of cyclohexylmethyl dialdehydes **15** and **16** and enol acetate **17**. Reagents and conditions: a) phosphonate **19** (1.3 equiv), LiOH·H~2~O (1.5 equiv), THF, 4 h, 15% (**25**), 1.5% (**26**); b) LiAlH~4~ (2.5 equiv), Et~2~O, 0 °C, 1 h, 61% (**27**), 71% (**28**); c) DMP (2.5 equiv), CH~2~Cl~2~, 4 h, 49% (**15**), 73% (**16**); d) Ac~2~O (2 equiv), pyridine (4 equiv), overnight, 43% (**17**).](Beilstein_J_Org_Chem-14-2229-g011){#C4} The electrophilic reactivity of model dialdehydes **11** and **15** and enol acetates **13** and **17** towards 1-pentanethiol and 1-pentylamine were then studied. As found for onchidal, no reaction (NMR tube) between **11**/**13**/**15**/**17** and 1-pentanethiol was detected, even after one week of incubation. In direct contrast, all four model compounds reacted rapidly with 1-pentylamine, forming pyrrole adducts. The reaction of dialdehyde **11** with 1-pentylamine afforded pyrrole adduct **29** almost instantaneously as determined by ^1^H NMR. Purification of the crude reaction product gave **29** as the free base (15% yield) and as the salt, **30** (also 15% yield, [Fig. 3](#F3){ref-type="fig"}). Spectroscopic and spectrometric analysis of **29** confirmed the formation of a diamine adduct, with detection of a protonated molecular ion in the (+)-ESI mass spectrum at *m*/*z* 307.3097 (C~20~H~39~N~2~ requires 307.3108) and NMR signals appropriate for a 3-substituted *N*-alkylpyrrole \[δ~H~ 6.57 dd, *J* = 2.3, 2.3 Hz, H-4\"; 6.54 br s, H-1\"; 6.04 dd, *J* = 2.3, 2.3 Hz, H-3\"; δ~C~ 120.8 (C-2\"), 120.3 (C-4\"), 118.4 (C-1\"), 106.2 (C-3\")\]. ![Pyrrole product **29** and salt **30** obtained from the reaction of dialdehyde **11** with *n*-pentylamine.](Beilstein_J_Org_Chem-14-2229-g004){#F3} As proposed for the onchidal--diamine adduct, the formation of **29** is presumably a consequence of dialdehyde **11** undergoing Paal--Knorr pyrrole formation to form an azafulvenium intermediate which is subsequently quenched with another mole of amine nucleophile to form the observed product ([Scheme 5](#C5){ref-type="fig"}). ![Reaction of dialdehyde **11** with excess 1-pentylamine to form **29**. Reagents and conditions: (a) 1-pentylamine (excess), CDCl~3~, overnight.](Beilstein_J_Org_Chem-14-2229-g012){#C5} Similar reactivity profiles were observed for each of cyclohexylmethyl dialdehyde **15**, and enol acetates **13** and **17**, with no reactivity towards 1-pentanethiol being detected, but with rapid reaction with 1-pentyamine to form pyrrole adducts. In the case of dialdehyde **15**, the reaction product was determined to be **31** (12% plus 18% as the salt, **32**, [Fig. 4](#F4){ref-type="fig"}), while enol esters **13** and **17** gave **29** and **31** (7% and 5% yields), respectively, upon reaction with the amine nucleophile. ![Pyrrole product **31** and salt **32** obtained from reaction of dialdehyde **15** with *n*-pentylamine.](Beilstein_J_Org_Chem-14-2229-g005){#F4} We next investigated the reactivity of onchidal (**6**) and analogues **11**--**13**

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srep30637-f5){#f5} ![Cell cycle phase distribution after exposure to radial extracorporeal shock waves.\ Data show relative numbers (mean ± SEM) of HFFF2 (**A**) and JEG-3 (**B**) cells in the G0/G1, S and G2/M phases 24 h after exposure to sham-rESWs (open bars) or to 500 rESWs (closed bars). \**p* \< 0.05.](srep30637-f6){#f6} ###### Examples of studies investigating the effects of focused (fESWs) and radial (rESWs) extracorporeal shock waves on musculoskeletal disorders including tendons in clinical settings, animal models, and fibroblast cultures. fESWs rESWs ------------------------ ----------------------------------------------------------------------------- ----------------------------------- --- Clinical setting Reviewed in Schmitz *et al*.[@b4] Reviewed in Schmitz *et al*.[@b4] Animal models Reviewed in Visco *et al*.[@b38] --- Fibroblast culture Viability Kaulesar Johannes *et al*.[@b22]Berta *et al*.[@b25]Hausdorf *et al*.[@b26] --- Growth potential Kaulesar Johannes *et al*.[@b22]Berta *et al*.[@b25] --- Gene expression Berta *et al*.[@b25] (TFG-β1,collagen type I and III) --- Growth factor release Hausdorf *et al*.[@b26] (FGF-2, TGF-β1) --- Cell cycle changes --- --- ###### Details of the statistical analysis of the quantitative analysis of cell viability after exposure to radial extracorporeal shock waves. Cell type P (ANOVA) P (Bonferroni *post hoc* tests for pairwise comparisons) ---------------------------- ----------- ---------------------------------------------------------- -------- -------- -------- ---- -------- -------- ---- -------- ---- Trypan blue negative cells HFFF2 \*\*\* ns \*\*\* \*\*\* \*\*\* ns \*\* \*\*\* ns \* ns JEG-3 \*\*\* ns ns \*\*\* \*\*\* ns \* \*\*\* \* \*\*\* \* Trypan blue positive cells HFFF2 \*\*\* ns \*\* \*\*\* \*\*\* ns \*\*\* \*\*\* ns \*\* ns JEG-3 \*\*\* ns ns \*\*\* \*\*\* ns \*\* \*\*\* ns \*\* ns Primary effects of rESWs on cell viability were analyzed using one-way ANOVA followed by Bonferroni *post hoc* tests for pairwise comparisons. \*p \< 0.05; \*\*p \< 0.01; \*\*\*p \< 0.001; ns, not significant. ###### Details of the statistical analysis of the quantitative analysis of cell count. Cell type P (ANOVA) P (Bonferroni *post hoc* tests for pairwise comparisons) ----------- ----------- ---------------------------------------------------------- -------- -------- ---- ---- -------- -------- HFFF2 \*\*\* \*\*\* \*\*\* 48 hrs ns \* \*\*\* \*\*\* 72 hrs \* \*\*\* \*\*\* \*\*\* JEG-3 \*\*\* \*\*\* \*\*\* 48 hrs ns ns ns \*\*\* 72 hrs ns ns ns \*\*\* Cell counts were analyzed by two-way ANOVA followed by Bonferoni *post hoc* tests for pairwise comparisons. The table shows results of comparisons between mean numbers of cells exposed to sham-rESWs and of cells exposed to rESWs at 48 and 72 hours after exposure. \*p \< 0.05; \*\*\*p \< 0.001; ns, not significant. ###### Details of the statistical analysis of the quantitative analysis of cell count influenced by conditioned medium (CM). Cell type P (ANOVA) P (Bonferroni *post hoc* tests for pairwise comparisons) ----------- ----------- ---------------------------------------------------------- -------- -------- ---- ---- -------- HFFF2 \*\*\* \*\*\* \*\*\* 48 hrs ns \* \*\*\* 72 hrs \* \*\*\* \*\*\* Cell counts were analyzed by two-way ANOVA followed by Bonferoni *post hoc* tests for pairwise comparisons. The table shows results of comparisons between mean numbers of cells exposed to sham-rESWs (cultured either in fresh culture medium or conditioned medium) and of cells exposed to 500 rESWs (cultured either in fresh culture medium or conditioned medium) at 48 and 72 hours after exposure. \*p \< 0.05; \*\*\*p \< 0.001; ns, not significant. Amending Kenya draft tricky, say Ministers March 26, 2010 12:00 am Shares By ANTHONY KAGIRI, NAIROBI, Kenya, Mar 26 – The reality of the daunting task of passing amendments to the Proposed Constitution started sinking on Friday with two Cabinet Ministers admitting that there are slim chances of success. Immigration Minister Otieno Kajwang said it was unlikely that the numerous amendments being fronted by Members of Parliament would pass the test of 145 members’ support to sail through. Mr Kajwang said with the battle lines between political parties already drawn, it was almost certain none of the amendments would pass. “Sixty five percent is close to unanimous and one will have to bring a very good amendment which almost all of us agree with,” said Mr Kajwang. The Minister however said there was a shared feeling that the Proposed Constitution is better than the current law, and would sail through the House with or without amendments “Our party (Orange Democratic Movement) had planned to push for the introduction of regions but we have noticed it is going to be a bit difficult to get agreement,” he added. Speaking elsewhere Justice and Constitutional Affairs Minister Mutula Kilonzo concurred with Mr Kajwang but said non-political issues could attract the numbers. He singled out the clause on abortion and the creation of the Parliamentary Fund as some which had support across the political divide. Mr Kilonzo however regretted that the failure by MPs to agree in their retreat early in the week had made the situation more difficult. “I would propose to those seeking amendments to seek support across the board and put the amendments that have considerable consensus in a package then we can vote for them in the House easily,” he told Capital News on phone from his Mbooni constituency. However as Members of Parliament rush to submit amendment proposals, a section were vowing to frustrate any amendments to the Proposed Constitution, saying their colleagues are out to mutilate the draft. Imenti Central MP Gitobu Imanyara on Friday claimed to have mobilised 80 MPs to prevent what he called entrenchment of the views of the status quo. “Those of us who are determined to bring a new Constitution have agreed to block all attempts for amendments,” he told Capital News. “We should not be worried by the sideshows and the narrow considerations that is behind a lot of these new proposed amendments.” MPs are scheduled to debate and vote on the amendments next Wednesday. By Thursday the office of the Clerk had 19 amendments surrounding abortion, Kadhis courts and the tenures of the Attorney General, Chief Justice and the Auditor and Controller General. There were unconfirmed reports that by Friday midday close to two hundred requests for amendments had reached the legal team. The team will however merge most of the proposals since they touch on similar matters. Should any of the amendments pass the document will be sent back to the Committee of Experts to incorporate them. Should the proposed document pass without amendments it will be forwaded to the Attorney General for publication in readiness for the referendum.Monday, August 8, 2016 First of all, just because I thought this was great, I want to share how my dad picked up this article, read it, and then kept asking again and again whether I had read it yet. I guess I know where I get my fascination with biology from! Second of all, CRISPR sounds like something to do with keeping salad greens fresh. It is obviously an acronym for something important and relating to the process, but still. Ok, now down to article. The genetics unit was my favorite; I loved how everything went together, how everything to do with how we operate is encoded in our DNA, and how we are still making new discoveries every day. It just amazed me--and still does. It is crazy to me, but also at the same time expected, that we can now edit DNA. (It seems like it would be possible when I think back to the way DNA is unwound and replicated that at some point during that time we would be able to go in there and edit the DNA. I’m not sure that’s when this gene editing would actually happen, but that would be interesting to know.) I was wondering when this time would come,

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2 is built: subset1 <- which(merge_stats$Time >= 6 & merge_stats$Time <= 10) p1 <- ggplot(merge_stats[subset1, ], aes(y = weight, x = as.numeric(Time))) + geom_jitter(color="grey", width=0.1)+ geom_errorbar(aes(ymin=SDbelow[subset1], ymax=SDabove[subset1]), width=0.1, size=1)+ stat_summary( geom = "point", fun.y = "mean", col = "blue", size = 2, shape = 19, fill = "blue") inset <- ggplotGrob(p1) ggplot(merge_stats, aes(y = weight, x = as.numeric(Time))) + geom_jitter(color="grey", width=0.1)+ geom_errorbar(aes(ymin=SDbelow, ymax=SDabove), width=0.1, size=1)+ stat_summary( geom = "point", fun.y = "mean", col = "blue", size = 2, shape = 19, fill = "blue") vp <- grid::viewport(width = 0.4, height = 0.4, x = 0.3, y = 0.7) print(p1, vp = vp) import { next } from '@ember/runloop'; import { describe, beforeEach, it } from 'mocha'; import { expect } from 'chai'; export default function(options) { let syncExternalChanges = options.syncExternalChanges || function() {}; let store; // eslint-disable-next-line mocha/no-top-level-hooks beforeEach(function() { store = options.store(); }); // eslint-disable-next-line mocha/no-top-level-hooks afterEach(function() { store.clear(); }); describe('#persist', function() { it('persists an object', async function() { await store.persist({ key: 'value' }); let restoredContent = await store.restore(); expect(restoredContent).to.eql({ key: 'value' }); }); it('overrides existing data', async function() { await store.persist({ key1: 'value1' }); await store.persist({ key2: 'value2' }); let restoredContent = await store.restore(); expect(restoredContent).to.eql({ key2: 'value2' }); }); it('does not trigger the "sessionDataUpdated" event', function(done) { let triggered = false; store.one('sessionDataUpdated', () => (triggered = true)); store.persist({ key: 'other value' }); syncExternalChanges(); next(() => { expect(triggered).to.be.false; done(); }); }); }); describe('#restore', function() { describe('when the store is empty', function() { it('returns an empty object', async function() { await store.clear(); let restoredContent = await store.restore(); expect(restoredContent).to.eql({}); }); }); describe('when the store has data', function() { beforeEach(function() { return store.persist({ key1: 'value1', key2: 'value2' }); }); it('returns all data in the store', async function() { let restoredContent = await store.restore(); expect(restoredContent).to.eql({ key1: 'value1', key2: 'value2' }); }); it('returns a copy of the stored data', async function() { let data = await store.restore(); data.key1 = 'another value!'; let restoredContent = await store.restore(); expect(restoredContent).to.eql({ key1: 'value1', key2: 'value2' }); }); }); }); describe('#clear', function() { it('empties the store', async function() { await store.persist({ key1: 'value1', key2: 'value2' }); await store.clear(); let restoredContent = await store.restore(); expect(restoredContent).to.eql({}); }); }); } Phospholipase A2 and its molecular mechanism after spinal cord injury. Phospholipases A(2) (PLA(2)s) are a diverse family of lipolytic enzymes which hydrolyze the acyl bond at the sn-2 position of glycerophospholipids to produce free fatty acids and lysophospholipids. These products are precursors of bioactive eicosanoids and platelet-activating factor which have been implicated in pathological states of numerous acute and chronic neurological disorders. To date, more than 27 isoforms of PLA(2) have been found in the mammalian system which can be classified into four major categories: secretory PLA(2), cytosolic PLA(2), Ca(2+)-independent PLA(2), and platelet-activating factor acetylhydrolases. Multiple isoforms of PLA(2) are found in the mammalian spinal cord. Under physiological conditions, PLA(2)s are involved in diverse cellular responses, including phospholipid digestion and metabolism, host defense, and signal transduction. However, under pathological situations, increased PLA(2) activity, excessive production of free fatty acids and their metabolites may lead to the loss of membrane integrity, inflammation, oxidative stress, and subsequent neuronal injury. There is emerging evidence that PLA(2) plays a key role in the secondary injury process after traumatic spinal cord injury. This review outlines the current knowledge of the PLA(2) in the spinal cord with an emphasis being placed on the possible roles of PLA(2) in mediating the secondary SCI.Q: Find descendants of a specific node with Xpath Say I have an xml document and want to get the "NodeID" and "Description" element out of each Node, without necessarily knowing whether they're a sub-element of some child, or just a child. <Stuff> <data> <Nodes> <NodeID>1</NodeID> <Name>thingA</Name> <MoreInfo> <Description>Scooter</Description> </MoreInfo> </Nodes> <Nodes> <NodeID>2</NodeID> <Name>thingB</Name> <MoreInfo> <Description>Bike</Description> </MoreInfo> </Nodes> </data> </Stuff> So I'd ideally end up with: 1, Scooter; 2, Bike. NodeList nodes = (NodeList) xpath.evaluate("Nodes", resultXml, XPathConstants.NODESET); for (int i = 0; i < nodes.getLength(); i++) { Node node = nodes.item(i); logger.info("Evaluating: " + node.toString()); String nodeID = xpath.evaluate("//NodeID", node); String description = xpath.evaluate("//DescriptionID", node); System.out.println("Found: " + nodeID + ", " + description); } The output is as follows: Evaluating: <NodeID>1</NodeID><Name>thingA</Name><MoreInfo><Description>Scooter</Description></MoreInfo> Found: 1, Scooter Evaluating: <NodeID>2</NodeID><Name>thingB</Name><MoreInfo><Description>Bike</Description></MoreInfo> Found: 1, Scooter The node is correct, but it keeps "finding" things as if it were looking from the beginning of the xml document. How do I search just for decendents of the node in question? I would think that the node being the source of the evaluation would do the trick... A: //NodeID and //Description are absolute paths which will start searching from the root of the document that contains the context node. The expressions in this case will match all nodes named NodeID (respectively Description) in the whole document, and when you evaluate such an expression as a string this will give you the string value of the first matching node in document order. To look just within the context node itself you need to use relative paths by adding a leading dot, for example .//NodeID. A bed of nails can actually be comfortable, if there are enough nails. A person's weight is divided by the number of nails under them. Here, Mr. Slab weighs 200 pounds, so the default bed is actually extremely painful. Adding more nails will help him a lot. You can replicate

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disclosed in Japanese Patent Publication No. 6457/89 is effective for preventing the development of a polarizing toner at an image edge portion, while it appears of substantially no effect on the aforementioned problem. Furthermore, toners having a variety of structures and processes for preparing the toners have been proposed for eliminating the aforementioned problems and improving the functions of toners. For example, there are proposed a toner in which conductive particles are fixed on the surface of a toner in a hot air stream and insulating particles are further fixed thereon in a hot air stream to form a structure having both a conductive layer and an insulating layer on the surface of the toner particles (Japanese Patent Laid-Open Publication No. 257763/88), toners having a multi-layer structure such as microcapsule toners prepared by the polymerization method and used for low-energy fixing (U.S. Pat. 3,080,250, Japanese Patent Publication Nos. 31066/84 and 36934/89), toners of which an external surface is coated with a charge control resin film layer for controlling charge with the use of the high speed impact method in the dry process (Japanese Patent Laid-Open Publication No. 62666/88) or a toner of which the surface has been treated with a resinous finely divided powder in order to obtain anti-blocking properties (Japanese Patent Laid-Open Publication No. 105261/89). These conventional toners, however, still have some points which needs to be improved.FEATURED SPONSORS The Am Law Litigation Daily: Feb. 10, 2009 Posted by Andrew Longstreth IP Obama Poster Case Is Rematch for Ex-Bingham Partner Falzone and O'Melveny's Cendali When an artist creates an iconic poster using a photograph taken by someone else, who owns the work? Shepard Fairey, the artist and guerilla marketer who designed the ubiquitous, two-toned "Hope" poster of President Barack Obama, has an answer: the artist. On Monday, Fairey sued The Associated Press in Manhattan federal district court, seeking a declaratory judgment that his use of an Obama photograph taken by AP photojournalist Mannie Garcia falls within fair use boundaries. On a side note, Fairey was arrested Friday in Boston on his way to an opening party for a retrospective of his work. Not for copyright violations, though: He had two outstanding warrants for cases involving illicit posting of street art featuring Andre the Giant and the word "obey." Jeffrey Wiesner of Boston's Stern Shapiro Weissberg & Garin is representing Fairey in the criminal case. No seismic shocks will come from the documents. The best details, including the names of the parties, have been redacted, reports Reisinger. But White & Case partner J. Mark Gidley, who negotiated the FOIA settlement, told Reisinger that antitrust lawyers can glean good information from the agreements, which he said "show deviations from the model amnesty letter in terms of privilege waivers and coverage of subsidiaries." Other antitrust attorneys, however, wonder if the White & Case FOIA suit may backfire on practitioners. Jones Day partner John Majoras told Reisinger he worries that the release of the agreements may end up stifling prosecutorial discretion. "If DOJ now says, 'We're just using the model letter,' then that's unfortunate for a company," he said. Appellate / Product Liability / Mass Torts Should Chief Justice (and Pfizer Shareholder) John Roberts Recuse Himself in Wyeth Preemption Case? While we anxiously wait for a decision from the Supreme Court in the biggest business case of the term, Wyeth v. Levine, Tony Mauro of Legal Times poses an interesting question: Should Chief Justice John Roberts, Jr., recuse himself from deliberations? After all, Roberts owns stock in Pfizer, which recently agreed to buy Wyeth for $68 billion. Roberts has stepped aside in previous Pfizer cases, according to Mauro. But the Court heard arguments in Levine back in November, and the chief justice may have made up his mind before the Pfizer acquisition was announced. Moreover, Pfizer's Wyeth deal won't be completed until July 31 at the earliest, according to a recent letter submitted by Wyeth's lawyer, Seth Waxman of Wilmer Cutler Pickering Hale and Dorr. In that letter (available here, via the Drug and Device Law blog), Waxman said that the proposed merger did not require Wyeth to update the corporate disclosure statement it made to the Court last year. Mauro speculates that Roberts could shed his Pfizer stock to avoid the recusal issue. Or he could stay on the case. "Either way," Mauro writes, "it will be an interesting test of whether news of an acquisition--even before it occurs--will affect justices' recusal practices." Securities UBS and the Foreign Plaintiffs: An 'F-Cubed' Class Action Story The Litigation Daily admits to an unaccountable (and possibly unhealthy) fascination with the F-cubed issue in securities class actions. So we're closely following the UBS AG case in Manhattan federal district court, in which investors, in the wake of the bank's $48.6 billion write-down on its mortgage-backed securities, claim that UBS issued false and misleading statements about its risk management controls, its exposure to risky assets, and the value of the securities on its books. Last week the plaintiffs filed a response to UBS's motion to dismiss claims brought by foreign plaintiffs who purchased UBS shares on foreign exchanges. In their response, lawyers for the plaintiffs argue that the foreign plaintiffs should be included in the proposed class because, among other things, UBS's alleged activity in the U.S. "directly caused foreign plaintiffs' losses." They also tried to distinguish their case from NAB, arguing that the UBS foreign plaintiffs, unlike their NAB counterparts, did not rely exclusively "on the falsity of financial statements prepared in [a foreign country] by a foreign issuer," they wrote. Securities Kasowitz Benson Files Auction-Rate Securities Suit for American Eagle Against Citigroup Long live the auction-rate securities scandal! Just as state and federal regulators appear to be wrapping up their investigations into banks that promoted the securities as safe and liquid investments even as the market for them had dried up, private litigation continues. The latest entrant is American Eagle Outfitters. The apparel company filed a suit in Pittsburgh federal district court last week against Citigroup, alleging that the bank induced it to buy auction-rate securities when Citigroup knew the market for them was collapsing. American Eagle's complaint cites internal Citigroup e-mails and memos showing that as the market for auction-rate securities imploded in December 2007, Citigroup sought to "offload" them to its customers, including American Eagle. According to the suit, Citigroup allegedly made internal plans to stop supporting the auction-rate securities market at the same time it was promoting the securities to its customers. American Eagle is using Kasowitz, Benson, Torres & Friedman in the ARS suit, proving once again that this is a good time to be a litigation boutique that's free to sue big banks. Appellate / Sports Watch It Live: Barry Ostrager and Maureen Mahoney to Argue America's Cup Case As Litigation Daily readers know, another of our unaccountable passions is the litigation surrounding the 33rd America's Cup. (Click here and here for our previous coverage.) On Tuesday at 2 p.m., we'll be able to watch it unfold live. The New York Court of Appeals (the state's highest court) is planning to Webcast oral arguments in the case of Golden Gate Yacht Club v. Société Nautique De Genève, which will determine the challenger of record for the next America's Cup, scheduled for 2010. Given the legal talent involved, it should be worth watching. Appellate ace Maureen Mahoney of Latham & Watkins will be arguing for the Golden Gate Yacht Club, whose BMW Oracle Racing team claims that it is the rightful challenger for the Cup. Barry Ostrager, head of the litigation department at Simpson Thacher & Bartlett, will be arguing for the current holder of the Cup, Société Nautique de Genève, whose Alinghi syndicate chose Club Nautico Espanol de Vela as the challenger of record for the 2010 race. David Rivkin of Debevoise & Plimpton, who represents Club Nautico Espanol, will also be allotted time during oral arguments at the court of appeals. Right now, Ostrager and Rivkin have the upper hand: In July the New York State Supreme Court issued a 3-to-2 ruling in favor of SNG. For a nice backgrounder on the fiercely fought litigation, check out this piece from Monday's International Herald Tribune./** * Copyright 2011-2019 Asakusa Framework Team. * * Licensed under the Apache License, Version 2.0 (the "License"); * you may not use this file except in compliance with the License.

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garden. Despite my protective clothing, eye mask and rubber gloves I was blantanly not rocking it as Superwoman. Luckily it was not the poo drain just the kitchen one otherwise there would have been more than retching going on. I live in an old house which to be fair is starting to cheese me off a bit now. I don’t even have central heating as there is no gas supply where we live. Yes really, 2017 and no gas supply has made it to some of the villages in this country yet. My drains are prehistoric to say the least and are a crude concrete design which means that most things stick to it on the way down. The poo one is always getting blocked as you can’t make a very good corner out of concrete and anything remotely larger than wee gets stuck on the sharp edge. I do draw the line at clearing that one though, which we usually have to do at least once a year. It is amazing how much they stink, after all the kitchen one is just waste from the washing machine and the sink isn’t it? It was grimy and sludgy and grey and smelly. Urgh! However, I cleaned it and picked out all the sludge and hosed it down and now it’s as good as new, well for a few months anyway. While I was feeling all manly I thought I would chop some logs for the fire. I have an open fire and although the ‘wood guy’ does bring me small stuff there are usually odd ones that could do with chopping in half. Yep, I definitely need a man for that. I gave up quite quickly after nearly losing my toes and instead decide to come indoors and build up my biceps first with a couple of baked bean tins. That lasted about one and half minutes. I have never been a gym bunny and it shows. I have wobbly bits and my arms are about as strong as spaghetti. Is it too late for me to toughen up? I am going to need to think seriously about this as it does not look there will be a man in my life anytime soon and as much as it pains me to admit it, the only thing I am likely to be able to chop is a carrot. Otherwise it has been a quiet weekend, with just me and the kids and I’m a celebrity. Well, I’m almost a celebrity more like but we still love it, if only for Ant and Dec. That is two weekends in a row with no dates and to be fair it has been quite nice. That’s not to say that I haven’t had any action, so to speak. One of the greatest messages I have received to date (apart from Christians offer of dirty sex, which I still dream about, sad as that may be), is below; “Hi, I’m 42, have a 2 bed flat live alone oh apart from a lodger whose rarely in , 3 kids (one grown up), work as a groundwork foreman, a little wild but big heart, impatient, passionate, all or nothing sort of man. Now this is exciting meeting someone you haven’t met before, John ???? look me up on Facebook and my address is 48 ???? and I don’t want to know about you as the excitement is heightened, I am waiting hard for you now.” Excitement, I’m bloody terrified not excited. Why would you give your full address out to a complete stranger and not just to me but probably to a dozen other woman who just happened to be online at that time. Crazy fool… and why don’t you want to know about me. You should want to know about me. You should at least want to know I am who I say I am, shouldn’t you? I know I said I wanted excitement but bloody hell. I would also like to make it to my next birthday. I declined to pop round that night or indeed ever. I don’t know what frightened me more the fact that he was naked and headless in his profile picture or the thought of his lodger who in my mind (I know It’s overactive) was like Jack the Ripper and just came back every now and then to rip out a few organs. Okay, I’m fessing up now, I’m struggling with this. I don’t know what I’m doing wrong but if they are sane they are too sane and if they are nuts they are really fucking nuts. Where do you go to find your average Joe these days. I can’t just loiter around in Waitrose on a daily basis like the papers suggest, fondling the aubergines. Who would look weird then? Two of the guys that are messaging me at the moment are married and blatantly so. They are assuming that honesty is the best policy and so are offering for ME to USE THEM and then if I meet someone who can offer something better then I can ditch them and we both move on. If not I can have NSA with them for as long as I want or they want, as long as I’m discreet. Oh what a lovely lot of humans we are. The others are the thirty somethings who want to have a casual regular sex thing (whatever that may be) or so they say… they talk a good talk at least. They don’t really seem to deliver on it though. I, on the other hand am really fed up with just talking about it. I love a bit of banter. Who doesn’t? I do also love a good bit of chat too though and a nice combination of both works for me. Remember J, he had it right, he talked a lot about all sorts of stuff, made me laugh a lot and was very flirty but not in a ‘any chance of a blow job’ kind of way, but in a sexual, teasing way. This it seems is rare. Luckily (tongue in cheek) there are two, yes just two, out of the 44,468 people currently online that can seem to be able to hold a conversation about something other than what is going on in their trousers and one of them has just asked me on a date. Quick as that. He messaged this morning, said Hi. Simple. Now we are having lunch in Brighton on Saturday. It’s a long way off yet and so I’m not going to start worrying about what to wear as a lot can happen in the virtual world of dating in 24 hours, nevermind 5 whole days. By Saturday I could have been swept of my feet unexpectedly by someone who works around the corner from me. Unlikely, but you never know. He could also have a date every night next week and the same could happen. So although I am looking forward to date number 7 (is it?), let’s not count our chickens. Brighton is a considerable distance from me and so I do hope it is worth the trip and the extortionate parking fees to visit somewhere considered to be so cosmopolitan. I also hope that it actually happens now as I’ve broadcast it to the world. It’s always a bit embarrassing when you announce something out loud and then have to say a few days later… oh, well he changed his mind actually, grass is greener and all that…. and trying to maintain your ‘I’m not really bothered face’ is even harder.Main Navigation Joanne Holden Jo is an accomplished Quality Management professional with over 20 years’ experience across a number of manufacturing and service industries including specialist carbon fibre production, chemical manufacture, printing technology, public sector, local authorities and education. In addition to her degree in Chemistry, she holds a Diploma in Statistical Quality Control and the Advanced Diploma in Human Resource Management. Since joining Equas in 2011, Jo has helped a wide range of manufacturing, construction, business services and social care businesses to achieve certification to ISO 9001, ISO 14001, OHSAS 18001/ISO 45001 and ISO 50001. Jo’s expert grasp of the ISO principles combined with her practical approach ensures that the work she does for our clients is both effective and durable. Joanne's clients Joanne's testimonials Our Consultant Jo Holden has been exceptional from day 1. She has been supportive and encouraging, she has been open and honest and is so approachable and easy to work with. She engages efficiently and confidently at all levels and has literally been a god send for me, going into something like this with no prior experience or knowledge of ISO - I was absolutely terrified and Jo gave myself and our Board of Directors the confidence not only to go for the two standards (9001, 14001) but to add on a 3rd (18001) and transition to 2015 on the first two within 5 months of initial certification. I cannot thank her or praise her enough. I would have no hesitation to recommend your services based on our fantastic experience with Jo. The service, support and experience has been exemplary. Kerry Lambson 27/05/2016 First Rail Support An absolutely outstanding service doing exactly what you said you could do, on budget and on time. I am hugely impressed. Thank you. As part of the Amtivo Group, Equas is a management consultancy that specialises in helping organisations improve their management systems, thereby enabling them to become more efficient and achieve more of their strategic objectives.Introduction {#s1} ============ Many mothers living in developing countries continue to die from pregnancy related morbidities each year [@pone.

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[couch_util:get_value(Key, SortedResults) || Key <- Keys]; reorder_results(Keys, SortedResults) -> KeyDict = dict:from_list(SortedResults), [dict:fetch(Key, KeyDict) || Key <- Keys]. url_strip_password(Url) -> re:replace(Url, "(http|https|socks5)://([^:]+):[^@]+@(.*)$", "\\1://\\2:*****@\\3", [{return, list}]). encode_doc_id(#doc{id = Id}) -> encode_doc_id(Id); encode_doc_id(Id) when is_list(Id) -> encode_doc_id(?l2b(Id)); encode_doc_id(<<"_design/", Rest/binary>>) -> "_design/" ++ url_encode(Rest); encode_doc_id(<<"_local/", Rest/binary>>) -> "_local/" ++ url_encode(Rest); encode_doc_id(Id) -> url_encode(Id). normalize_ddoc_id(<<"_design/", _/binary>> = DDocId) -> DDocId; normalize_ddoc_id(DDocId) when is_binary(DDocId) -> <<"_design/", DDocId/binary>>. with_db(DbName, Fun) when is_binary(DbName) -> case couch_db:open_int(DbName, [?ADMIN_CTX]) of {ok, Db} -> try Fun(Db) after catch couch_db:close(Db) end; Else -> throw(Else) end; with_db(Db, Fun) -> case couch_db:is_db(Db) of true -> Fun(Db); false -> erlang:error({invalid_db, Db}) end. rfc1123_date() -> {{YYYY,MM,DD},{Hour,Min,Sec}} = calendar:universal_time(), DayNumber = calendar:day_of_the_week({YYYY,MM,DD}), lists:flatten( io_lib:format("~s, ~2.2.0w ~3.s ~4.4.0w ~2.2.0w:~2.2.0w:~2.2.0w GMT", [day(DayNumber),DD,month(MM),YYYY,Hour,Min,Sec])). rfc1123_date(undefined) -> undefined; rfc1123_date(UniversalTime) -> {{YYYY,MM,DD},{Hour,Min,Sec}} = UniversalTime, DayNumber = calendar:day_of_the_week({YYYY,MM,DD}), lists:flatten( io_lib:format("~s, ~2.2.0w ~3.s ~4.4.0w ~2.2.0w:~2.2.0w:~2.2.0w GMT", [day(DayNumber),DD,month(MM),YYYY,Hour,Min,Sec])). %% day day(1) -> "Mon"; day(2) -> "Tue"; day(3) -> "Wed"; day(4) -> "Thu"; day(5) -> "Fri"; day(6) -> "Sat"; day(7) -> "Sun". %% month month(1) -> "Jan"; month(2) -> "Feb"; month(3) -> "Mar"; month(4) -> "Apr"; month(5) -> "May"; month(6) -> "Jun"; month(7) -> "Jul"; month(8) -> "Aug"; month(9) -> "Sep"; month(10) -> "Oct"; month(11) -> "Nov"; month(12) -> "Dec". integer_to_boolean(1) -> true; integer_to_boolean(0) -> false. boolean_to_integer(true) -> 1; boolean_to_integer(false) -> 0. validate_positive_int(N) when is_list(N) -> try I = list_to_integer(N), validate_positive_int(I) catch error:badarg -> false end; validate_positive_int(N) when is_integer(N), N > 0 -> true; validate_positive_int(_) -> false. find_in_binary(_B, <<>>) -> not_found; find_in_binary(B, Data) -> case binary:match(Data, [B], []) of nomatch -> MatchLength = erlang:min(byte_size(B), byte_size(Data)), match_prefix_at_end(binary:part(B, {0, MatchLength}), binary:part(Data, {byte_size(Data), -MatchLength}), MatchLength, byte_size(Data) - MatchLength); {Pos, _Len} -> {exact, Pos} end. match_prefix_at_end(Prefix, Data, PrefixLength, N) -> FirstCharMatches = binary:matches(Data, [binary:part(Prefix, {0, 1})], []), match_rest_of_prefix(FirstCharMatches, Prefix, Data, PrefixLength, N). match_rest_of_prefix([], _Prefix, _Data, _PrefixLength, _N) -> not_found; match_rest_of_prefix([{Pos, _Len} | Rest], Prefix, Data, PrefixLength, N) -> case binary:match(binary:part(Data, {PrefixLength, Pos - PrefixLength}), [binary:part(Prefix, {0, PrefixLength - Pos})], []) of nomatch -> match_rest_of_prefix(Rest, Prefix, Data, PrefixLength, N); {_Pos, _Len1} -> {partial, N + Pos} end. callback_exists(Module, Function, Arity) -> case ensure_loaded(Module) of true -> InfoList = Module:module_info(exports), lists:member({Function, Arity}, InfoList); false -> false end. validate_callback_exists(Module, Function, Arity) -> case callback_exists(Module, Function, Arity) of true -> ok; false -> CallbackStr = lists:flatten( io_lib:format("~w:~w/~w", [Module, Function, Arity])), throw({error, {undefined_callback, CallbackStr, {Module, Function, Arity}}}) end. check_md5(_NewSig, <<>>) -> ok; check_md5(Sig, Sig) -> ok; check_md5(_, _) -> throw(md5_mismatch). set_mqd_off_heap(Module) -> case config:get_boolean("off_heap_mqd", atom_to_list(Module), true) of true -> try erlang:process_flag(message_queue_data, off_heap), ok catch error:badarg -> ok end; false -> ok end. set_process_priority(Module, Level) -> case config:get_boolean("process_priority", atom_to_list(Module), false) of true -> process_flag(priority, Level), ok; false -> ok end. ensure_loaded(Module) when is_atom(Module) -> case code:ensure_loaded(Module) of {module, Module} -> true; {error, embedded} -> true; {error, _} -> false end; ensure_loaded(_Module) -> false. %% This is especially useful in gen_servers when you need to call %% a function that does a receive as it would hijack incoming messages. with_proc(M, F, A, Timeout) -> {Pid, Ref} = spawn_monitor(fun() -> exit({reply, erlang:apply(M, F, A)}) end), receive {'

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y*, *z*; (iii) *x*, −*y*+3/2, *z*−1/2. ###### Hydrogen-bond geometry (Å, °) *D*---H⋯*A* *D*---H H⋯*A* *D*⋯*A* *D*---H⋯*A* ------------------- --------- ------- ----------- ------------- C2---H2⋯O1^i^ 0.93 2.48 3.368 (2) 159 C5---H5⋯O3^ii^ 0.93 2.62 3.539 (2) 169 C13---H13⋯O3^iii^ 0.93 2.67 3.601 (2) 174 Symmetry codes: (i) ; (ii) ; (iii) . Very interesting. New to the site, and have already noticed something quite odd. In Freestyle play order, you cannot go first if went last on the previous round. This is fair so you cannot take countries, and go first to claim the bonuses. The website LOCKS your turn until someone else takes theirs right? WRONG. The website only locks your turn until someone else BEGINS their turn! You can take your turn last, and sit there clicking refresh until someone clicks: "begin turn." At which point, if you are fast enough, you can take your turn(collect units, deploy units and reinforce etc etc) BEFORE anyone else gets to do anything. You can see that this is the reason why the rule was implemented in the first place. Granted (before I go into this any further), I will admit, I know "Freestyle" play is not an original and solid play-style, mainly used for fun. But still, in order to keep the way it was designed balanced, I propose the following: CHANGE NOTHING in the way Freestyle turn order is played, just IMPLEMENT THE RULE that is already described in the Freestyle Rules. Simply LOCK the turn of the player who took the last turn in the previous round until at least one person COMPLETELY finishes his or her turn. A player must hit: "End Reinforcements" in-order for the previous round's Last-Turn-Taker to unlock his/her turn. Is this not the essence of the rule? Making sure someone cannot take two turns in a row? The way it is now, you can. Thanks. kylegraves1 wrote:what you have described would be seq in a 2 player game where the hell did this come from the idea is shit What you have described would be classic asshattery and the instant flaming against a new member(or anyone for that matter) is against forum rules. Don't be a dick... Currently, in Freestyle turn play, you can take TWO TURNS IN A ROW... Take your turn last, and wait until someone STARTS THEIR TURN. Then you take your turn since your "begin turn" button unlocks as soon as someone else "clicks start." You haven't played very many freestyle games either... You can take two turns in a row by simply not ending your turn. If your the last person to go, just let the clock run out and then you can take your turn again. I think that's a bigger issue than what you're talking about. In heaven... Everything is fine, in heaven... Everything is fine, in heaven... Everything is fine... You got your things, and I've got mine. hecter wrote:You haven't played very many freestyle games either... You can take two turns in a row by simply not ending your turn. If your the last person to go, just let the clock run out and then you can take your turn again. I think that's a bigger issue than what you're talking about. Thanks for adding to my side of the argument, in a different way ;p That issue would be fixed along with the one I described by implementing what I proposed. PS, wtf does I haven't played many freestyle games either mean? Is everyone on these forums a dick? Imma go cry now. j35t3r.us wrote:PS, wtf does I haven't played many freestyle games either mean? Well, you just said that kyle hasn't played many freestyle games, but you're complaining about something that's a bit of a non-issue... Part of the fun of speed-freestyle is waiting for your opponent to start their turn so you can go as quickly as you can to get your armies. I really wouldn't like it if I couldn't do that anymore... Getting rid of the "Run out of time and get another turn" thing would be cool though. j35t3r.us wrote: Is everyone on these forums a dick? No, just most of us j35t3r.us wrote:Imma go cry now. Have fun! In heaven... Everything is fine, in heaven... Everything is fine, in heaven... Everything is fine... You got your things, and I've got mine. PS, wtf does I haven't played many freestyle games either mean? Is everyone on these forums a dick? Imma go cry now. Hectar wasn't being a dick, you obviously haven't played many freestyle games, as you are complaining about something that was built into the site in a specific way. There are lots more tricks to Freestyle, try playing a team game in Freestyle and see what happens! Give yourself some time around here, complete 20 or so games, then review what you have learned. Then, review the forum guidelines. If you are struggling to find that link it is on the top of every forum page. Here is an important piece of advice: One: Is my post really necessary or is it just mental diarrhea?Two: Am I trolling or feeding a troll?Three: Really? This last question should be asked at least twice but is often ignored because everyone likes to think that they are saying something ground breaking when in fact “GFYS muthafugging azzhole” and “you suck dick” are in fact not new and the only thing they will break is your reputation. Number three applies here. Are you saying something ground breaking, or is this something almost everyone else here already knows? Now, if we take your suggestion seriously, let's think for a minute: If you can't go until someone else COMPLETES there move, what is to stop them from taking too long for you to complete your own move? Now, going last in a round is basically resigning yourself to missing your next turn entirely. Finally, please use the proper form when posting in this board. Suggs and Bugs (that's this one) has a specific format. So do Cheating and Abuse, and the Create/Join Clan, and the Create/Join Tournaments, and a host of others. You have been treated fairly and generously. Please read the FAQ and Forum Guidelines. People are generally willing to help here, they just don't always use pleasantries. That is what Hectar was doing. Also, if you want to be treated seriously and nicely, do everyone else the favor and following the rules and guidelines. Thank you, and good luck at your games on CC and the Forums.-Snowman *EDIT: Was fastposted by Hectar, but what I said also still applies. Also, I don't count ANY completed Freestyle games on your profile...This invention relates to positioners in general and, more particularly, to adjustable positioners for positioning patients for medical procedures. Many medical procedures require that a patient's body or portion thereof, such as a limb, or limbs, be positioned in a particular manner. One common method for positioning a body part is to simply have an assistant hold the body part in a desired position, and change the position when requested by the physician or surgeon. As can be appreciated this method is tiring for the assistant. In addition, this method may not support the patient's body part in a sufficiently precise and rigid manner for the medical procedure. Moreover, if more than one body part needs to be positioned, several assistants have to be utilized, which is inefficient and crowds the work area around the patient. Other methods for positioning a body part utilize adjustable mechanical positioners. One common adjustable positioner is a sling that is attached to a body part and is connected by cables and pulleys to a ceiling, a free-standing support, or a boom extending from an operating table. These types of positioners are difficult to set up and take down, clumsy to adjust, and often obstruct the work area around the patient. In the field of obstetrics and gynecology, a chair or table with movable leg stirrups is typically used to adjustably position the lower portion of a patient. The stirrups, however, typically have a limited range of movement and, thus, can only support the legs of a patient in a limited number of positions. Moreover, such chairs or tables are specialized and have limited utility in other medical fields. In the field of orthopedics, a limb positioner pivotally attached to a table or chair is often used to position the arm or leg of a patient. Such a limb positioner, however, has a limited range of movement and, thus, can only support the arm or leg of a patient in a limited number of positions. Moreover

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? I want to download some static websites. I have begun the process, but it seems that the maximum speed I can set to the GUI is a shade shorter than 1Mbps. My down-link is steady until 54 Mbps, so I was wondering - how do I make HTTrack download, say, at 15MBps? A: You need to put 0 for max transfer rate and add --disable-security-limits in the scan rules box + 2nd screen that William Hilsum posted. A: Unless you are downloading from an office with a hefty internet connection or you have a good fibre connection, it is unlikely (but not impossible) you are connected to the internet at 54MBs, this is infact the speed that your computer is connected to the wireless router. 1Mbps may be the limit of your connection, other than that, I use HTTrack and whilst it is very good, it is slow as it has to index the site and build up a list of files to download. If you want to check for limits, before you start the download, click on Set options... and you should be able to set any limit you want under the Limits or Flow Control tabs. A: I set the follow and am spiking at 17MiB/s on a 100Mb/s connection. Limits: Max transfer rate (B/s) = 0 B/s Max connections / second = Blank Flow Control: Number of connections = 99 Persistent connection (Kepp-Alive) = Check (enabled) enter image description here --- author: - 'A. Kalz, A. Honecker, S. Fuchs' - 'T. Pruschke' date: 'Received: May 7, 2008 / Revised version: July 18, 2008' title: Phase diagram of the Ising square lattice with competing interactions --- Introduction \[intro\] ====================== The search for exotic groundstates in two-dimensional frustrated quantum spin systems is a topic of intense research (see, e.g., Refs. [@P:misguich05; @P:richter04] for recent reviews). In this context, the antiferromagnetic $J_1$-$J_2$ spin-1/2 Heisenberg model on the square lattice has been intensively studied during the past two decades. Nevertheless, the nature of an intermediate non-magnetic phase around $J_2 \approx J_1/2$ has remained under debate until recently (see Refs. [@P:misguich05; @P:mambrini06] and references therein). Among the possible approaches to the antiferromagnetic $J_1$-$J_2$ Heisenberg model, quantum Monte-Carlo (QMC) simulations suffer from a severe sign problem in the region $J_2 \approx J_1/2$. Other approaches include perturbation theory around the Ising limit [@P:oitmaa96; @P:singh03]. A closely related model is given by hard-core bosons on the square lattice with nearest neighbour (NN) and next-nearest neighbour (NNN) hopping and repulsion terms [@P:batrouni00; @P:batrouni01; @P:wessel08; @P:chen08]. In this case, there is no sign problem such that QMC simulations are possible in principle [@P:batrouni00; @P:batrouni01; @P:wessel08; @P:chen08]. However, simple QMC algorithms suffer freezing problems in the intermediate regime at $J_2 = J_1/2$ which can be traced to a groundstate degeneracy of the Ising limit. This motivated us to perform a model study by solving the related freezing problems in Monte-Carlo (MC) simulations of the Ising model. Investigations of the two-dimensional $J_1$-$J_2$ Ising model on the square lattice have an even longer history than of the corresponding Heisenberg model, including in particular MC simulations (see, e.g., [@P:SK79; @P:landau80; @P:landaubinder80; @P:landaubinder85; @P:bloete87; @P:MKT06; @B:landaubinder]). Nevertheless, certain issues have remained controversial also in the case of the Ising model, in particular the nature of the finite-temperature phase transition for $J_2 > J_1/2$: MC simulations [@P:SK79; @P:landaubinder85; @P:MKT06] and an investigation of the Fisher zeros of the partition function [@P:monroe07] have suggested non-universal critical exponents, whereas a variational approach [@P:lopez93] and a differential operator technique [@P:AVS08] predict a first-order transition for $J_1/2 < J_2 \lesssim J_1$. In this paper we resolve this issue in favour of a weak first-order transition at least for not too large $J_2 > J_1/2$ by providing substantially improved MC results for the phase diagram. This paper is organized as follows: in section \[sec:model\] we introduce the $J_1$-$J_2$ Ising model on the square lattice and discuss its $T=0$ groundstates. The MC simulation methods are described in section \[sec:methods\] and results are presented in section \[sec:results\]. We conclude with a summary and outlook in section \[sec:discussion\]. Model \[sec:model\] ------------------- We study the classical Ising model with competing antiferromagnetic interactions $J_1$ on the NN bonds and $J_2$ on the NNN bonds ($J_i > 0$): $$\begin{aligned} H = J_1 \sum_{\text{NN}} S_i S_j + J_2 \sum_{\text{NNN}} S_i S_j \, , \quad S_i =\pm1 \, . \label{eq:En}\end{aligned}$$ We will study square lattices of linear extent $L$ with periodic boundary conditions. For $J_2 = 0$ the groundstate of (\[eq:En\]) is the known antiferromagnetic solution which is a Néel ordered lattice (see Fig. \[fig:degeneracy\], left) with energy $E = -2 J_1 N$ ($N = L^2$ is the number of sites). Switching on the repulsive interaction on the diagonal (NNN) bonds of the square lattice yields an increase of the groundstate energy for the Néel-ordered state: $$\begin{aligned} E_{\text{N\'eel}} = -2 N (J_1-J_2) \, .\end{aligned}$$ For large $J_2$ the system orders in the collinear (or superantiferromagnetic) phase (see Fig. \[fig:degeneracy\], right) where all diagonal bonds are antiferromagnetic, while half of the NN bonds is antiferromagnetic and the other half is ferromagnetic. Thus, the energy in this state depends only on $J_2$: $$\begin{aligned} E_{\text{Coll}} = -2 N J_2 \, .\end{aligned}$$ The critical point separating these two phases lies at $J_2 = J_1/2$, where the transition temperature is suppressed to $T=0$. At this point the groundstate is highly degenerate. More precisely, there are $2^{L+1}-2$ groundstates which can be obtained as follows: flipping a line of antiparallel spins costs no energy at $J_2 = J_1/2$. Thus, one can generate almost $2^{L+1}$ groundstates from a Néel state by flipping either the $L$ horizontal or the $L$ vertical lines independently (the second Néel state can be reached in both ways). In particular, one can reach a collinear state through a series of intermediate groundstates by $L/2$ line flips, as sketched in Fig. \[fig:degeneracy\]. Accordingly, close to the critical point $J_2 = J_1/2$ the energy landscape is characterized by many local minima which are separated by large energy barriers. Therefore, MC simulations using only single-spin flips have problems to reach the configuration with global minimum energy. To solve this problem and to obtain transition temperatures also in the vicinity of $J_2 = J_1/2$ we implemented improved MC algorithms which we will discuss in the next section. Methods \[sec:methods\] ======================= Computational methods \[sec:comp\] ---------------------------------- We first tried to simulate the model with competing interactions using conventional single-spin flip MC simulations [@B:landaubinder]. However, near the critical point this algorithm does not provide proper results and suffers severe freezing problems in the proximity of the critical temperature and below. To overcome these problems we implemented a parallel tempering algorithm [@P:huku96; @P:marinari98; @P:hans97; @P:trebst06]: a number of simulations with the same set of parameters ($J_1$, $J_2$, $L$) but varying temperatures are simulated simultaneously. After a sufficiently large number of sweeps over the complete lattice an additional MC step proposes a configuration swap between neighbouring simulations with an acceptance rate $p(i,i+1)$: $$\begin{aligned} p(i,i

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for species of conservation concern" that represent habitats in a significant state of decline. Recommendation: To improve NRCS's implementation of the Conservation Security Program, the Secretary of Agriculture should direct the Chief of NRCS to include a reference to the national guidance for wildlife habitat assessment criteria in NRCS's Conservation Programs Manual. Agency Affected: Department of Agriculture Status: Closed - Implemented Comments: According to Natural Resources Conservation Service (NRCS) officials, the agency directed its state offices to submit a copy of their wildlife habitat assessment criteria for all proposed Conservation Security Program (CSP) watersheds. These criteria were examined for consistency with NRCS's national CSP guidance [i.e., minimum national eligibility criteria for wildlife habitat] by the Deputy Chief for Science and Technology's National Biology Team in Ft. Worth, Texas. Discrepancies with the national guidance were resolved in cooperation with the relevant NRCS State Conservationists. Recommendation: To improve NRCS's implementation of the Conservation Security Program, the Secretary of Agriculture should direct the Chief of NRCS to review and field check each NRCS state office's wildlife habitat assessment criteria to ensure that states use consistent criteria and achieve the habitat benefits intended by the national guidance. Agency Affected: Department of Agriculture Status: Closed - Implemented Comments: According to the Natural Resources Conservation Service (NRCS), it created an automated system within its ProTracts contracting software to compare existing Wildlife Habitat Incentives Program, Agricultural Management Assessment, and Environmental Quality Incentives Program (EQIP) contracts with existing CSP contracts to reveal potential areas of overlapping conservation practices and payments. Using this system, NRCS officials indicated in March 2009 that they had identified more the 370 duplicate payments between CSP and EQIP totaling about $420,000. NRCS indicated that these cases of duplication were dealt with according to the NRCS contracting manual, although the agency did not identify the amount of duplicate payments recovered. In addition to creating this automated system, NRCS issued National Bulletin 300-7-1, Conservation Security Program (CSP) Potential Duplicative Payments, to enlist the assistance of its state offices to identify potential or actual duplicate payments between CSP and other programs, and to take action to modify contracts to preclude duplicate payments or recover duplicate payments already made. The bulletin notes that despite statutory provisions and previous NRCS actions to prevent CSP from duplicating other programs, GAO found that the potential for duplicate payments still exists and such payments have occurred. Among other things, the bulletin directs the state offices to compare conservation activities under CSP contracts with those under contracts related to other programs to determine whether duplicate payments are planned or have occurred. The bulletin also provides guidance on recognizing situations that constitute duplication, including examples of conservation activities under CSP and another program that would or would not be considered the same. In addition, the bulletin requires each state office to complete a Potential Duplicate Report and submit it to the Director of NRCS's Financial Assistance Programs Division. Recommendation: To improve NRCS's implementation of the Conservation Security Program, the Secretary of Agriculture should direct the Chief of NRCS to develop a process to efficiently review existing CSP contracts to identify cases where CSP payments duplicate payments made under other programs and take action to recover appropriate amounts and to ensure that these duplicate payments are not repeated in fiscal year 2006 and beyond.For Zealong Organic Dark oolong tea, longer roasting gives these leaves a rich, deep taste and a hint of charcoal on the nose, yet no bitterness. Perfect for lovers of whole leaf, these leaves are packed in vacuum-packed foil and housed in a slim, low-profile bookshelf style package designed to protect the integrity of whole leaf. Utmost care has been taken to ensure that leaves arrive intact to deliver exceptional flavours across multiple infusions. You may also like… Perfect for lovers of whole leaf, these leaves are packed in vacuum-packed foil and housed in a slim, low-profile bookshelf style package designed to protect the integrity of whole leaf. Utmost care has been taken to ensure that leaves arrive intact to deliver exceptional flavours across multiple infusions. For Zealong Organic Aromatic oolong tea, leaves are briefly roasted at high temperatures, producing a clear aroma and taste, with a hint of fruit and flowers. Perfect for lovers of whole leaf, these leaves are packed in vacuum-packed foil and housed in a slim, low-profile bookshelf style package designed to protect the integrity of whole leaf. Utmost care has been taken to ensure that leaves arrive intact to deliver exceptional flavours across multiple infusions. The ideal gift for the tea connoisseur! The whole Zealong organic tea range at an attractive price, including Pure, Aromatic, and Dark oolong teas, as well as our extremely popular Green and Black teas. For Zealong Organic Pure oolong tea, these sweet, fresh-tasting leaves are unroasted, bringing out the pure, natural flavour of the tea. Perfect for lovers of whole leaf, these leaves are packed in vacuum-packed foil and housed in a slim, low-profile bookshelf style package designed to protect the integrity of whole leaf. Utmost care has been taken to ensure that leaves arrive intact to deliver exceptional flavours across multiple infusions. Case: 14-11131 Date Filed: 09/30/2014 Page: 1 of 10 [DO NOT PUBLISH] IN THE UNITED STATES COURT OF APPEALS FOR THE ELEVENTH CIRCUIT ________________________ No. 14-11131 Non-Argument Calendar ________________________ D.C. Docket No. 5:13-cr-00009-WTM-JEG-1 UNITED STATES OF AMERICA, Plaintiff-Appellee, versus RUSSELL JAY NEWELL, Defendant-Appellant. ________________________ Appeal from the United States District Court for the Southern District of Georgia ________________________ (September 30, 2014) Before TJOFLAT, HULL and JORDAN, Circuit Judges. PER CURIAM: Case: 14-11131 Date Filed: 09/30/2014 Page: 2 of 10 After pleading guilty, Russell Jay Newell appeals his total 188-month sentence for possession of a firearm by a convicted felon, in violation of 18 U.S.C. § 922(g)(1) (Count 1), and possession with intent to distribute methamphetamine, in violation of 21 U.S.C. § 841(a)(1) and (b)(1)(C) (Count 2). On appeal, Newell contends his sentence is unreasonable. After review, we affirm. I. BACKGROUND On July 18, 2013, Newell pled guilty to both counts. Subsequently, the government discovered that Newell had three qualifying prior convictions under the Armed Career Criminal Act (“ACCA”), 18 U.S.C. § 924(e). The government filed an unopposed motion asking the district court to hold a supplemental plea hearing to advise Newell that he was subject to the ACCA’s increased 15-year mandatory minimum and life maximum penalties. On January 6, 2014, the district court held a supplemental plea hearing, at which Newell re-entered his guilty plea. Newell’s Presentence Investigation Report (“PSI”) listed three juvenile convictions and nine adult convictions in the state of Georgia. Newell’s adult convictions included: (1) a 1997 conviction for theft by receiving stolen property; (2) 1997 convictions for theft by taking and burglary; (3) a 1998 conviction for burglary; (4) a 2005 conviction for possession of methamphetamine; (5) a 2009 conviction for giving false information to a law enforcement officer; (6) a 2009 conviction for manufacturing methamphetamine; (7) a 2011 conviction for 2 Case: 14-11131 Date Filed: 09/30/2014 Page: 3 of 10 criminal damage to property; (8) 2011 convictions for fleeing or attempting to elude, and giving false information to, a law enforcement officer; and (9) a 2012 conviction for theft by receiving stolen property. As to Count 2, the PSI recommended that, based on Newell’s 1998 burglary and 2009 methamphetamine manufacturing convictions, Newell was a career offender, pursuant to U.S.S.G. § 4B1.1(b)(3), with an offense level of 32. As to Count 1, the PSI recommended that, based on those same two convictions and Newell’s 1997 burglary conviction, Newell was an “armed career criminal” under 18 U.S.C. § 924(e) and U.S.S.G. § 4B1.4(b)(3)(A), which resulted in an offense level of 34 because Newell had possessed a firearm in connection with a controlled substance offense. Because Newell was subject to both offense-level increases, the PSI recommended applying the higher, armed career criminal offense level of 34. See U.S.S.G. § 4B1.4(b) (instructing the district court to apply the offense level that is the greatest). After a three level

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I don't necessarily have to believe what you believe, but we won't tell you what to believe — you know, props for that. Respect. Total respect for that," Alumit says. This was exactly the intent of Sanderson Jones and Pippa Evans when they started Sunday Assembly in the United Kingdom. "There are loads of people out there who want to live better, help often and wonder more," Jones says in a crowdfunding video pitching their idea for godless congregations. "It's all the best bits of church, but with no religion and awesome pop songs," Evans says. "And it's not a cult," Evans adds. "But that's exactly what we'd say if it were a cult," the pair deadpan. This lighthearted approach seems to be reaching a growing number of nonreligious people. "This is a big boom now of secularity — people not wanting to associate with religion, not wanting to identify as religious," says Phil Zuckerman, who teaches about secularism at Pitzer College in Southern California. Zuckerman says his research shows that 20 percent of Americans say they are nonreligious. And among people younger than 30 years old, that number is 30 percent, he says. "Some people who were raised with religion rejected it for certain reason that leaves them with a bitter taste in their mouth about religion: either they had bad experiences in their church, or they saw hypocrisy in the youth pastor, or they felt that religion was manipulative or all the litany of reasons people might not like religion," Zuckerman says. "Those people are a little bit angry at religion." He says Sunday Assembly appeals to more optimistic atheists — those hoping to re-create what they felt was good about religion. "They miss the community, they miss the music, they miss the multigenerational coming together with people that you might not otherwise be hanging out with," he says. "But they don't want to go to a place where they have to keep their intellect on hold. They don't want to push pause on the skepticism button in their mind." Aiming To Stay Dogma-Free Zuckerman notes that there have been secular organizations for years, like the Ethical Culture Society, American Atheists, Humanist centers, some nondogmatic Unitarian chapters and organizations fighting for political and social causes. But unlike some of these groups, he says, Sunday Assembly is not out to critique or debunk religion. That approach is what drew TV animator David Hernston, 38, and retiree Valerie Stansfield, 75. "I don't believe in God, and so going to church, even with Unitarian church, it's not so explicitly God-y, but there's still some spirituality that just doesn't resonate for me at all, so I've been hoping for this sort of community experience for a long time," Hernston says. "I think it will grow," Stansfield says. "There's a lot of people who feel spiritual, they want the spiritual feelings, they want the celebration. It's natural. All humans love it." Ian Dodd, one of the co-founders of LA's Sunday Assembly chapter, is a camera operator for TV shows like Community and True Blood by day. "I got involved with Sunday Assembly about last February or March when I first started seeing the stories online about the London assembly. And by August we had a website and a YouTube channel, and we had 900 people signed up ahead of time, and here we are at our second assembly. We take our nonbelief as a beginning point, not an end point," he says, "because this is the here and now, and this is all we can count on. What is it we're going to do to make a difference here?" The members in Los Angeles were encouraged to volunteer to read to children at a downtown elementary school, to donate blood and to plant some trees with a local charity organization. In addition to Sunday Assembly, Dodd is a member of the Unitarian church in Santa Monica. He was once a practicing Buddhist who also dabbled in various New Age philosophies. "As a young adult, I went off on my exploration and checked out this and that and tried to find something that was bigger than myself," he says. "And I discovered that the universe in itself is bigger and more fantastic and more awe-inspiring than any story that human beings have ever created for themselves." Dodd does acknowledge that Sunday Assembly is not without its factional schisms, like many religions. He says the newly formed chapter in New York has already split over how much to emphasize atheism. But he says the Los Angeles group is staying away, for now, from any kind of dogma, pro or con. Copyright 2014 NPR. To see more, visit http://www.npr.org/. Transcript RENEE MONTAGNE, HOST: Let's hear now about Sunday Assembly. It's the brainchild of two British comedians who started a church for people who don't believe in God. They launched Sunday Assembly just a year ago and already its spread across the globe. In this country, there are now around 30 Sunday Assembly chapters. MANDALIT DEL BARCO, BYLINE: It sometimes feels like church in the auditorium of the Professional Musicians Union in Hollywood. (SOUNDBITE OF GUITAR MUSIC) BARCO: Hundreds of people are gathered on a Sunday morning to meditate, listen to inspirational poetry and stories, and to sing. UNIDENTIFIED MAN #1: The words going to be on the screen. (SOUNDBITE OF SONG, "REVOLUTION") UNIDENTIFIED MAN #2: (Singing) You say you want a revolution... BARCO: There's a live band performing songs by the Beatles, the Rolling Stones and Jerry Lee Lewis. And instead of a sermon, there's a lecture by experimental psychologist and neuroscientist Jessica Kale about the biology of gender identification and sexual orientation. JESSICA KALE: What I want to get across is gender is a spectrum. It's not a binary thing. We've got manly men, we've got girly girls, and we've got everything in between. And I think we all kind of accept that we're somewhere in between these two. BARCO: Mostly at the Sunday Assembly, there is no God talk. That appealed to divinity student Noel Alumit. NOEL ALUMIT: I don't necessarily have to believe what you believe, but we won't tell you what to believe - you know, props for that, respect. Total respect for that. You know... (LAUGHTER) ALUMIT: ...total respect for that. BARCO: That was exactly the intent of Sanderson Jones and Pippa Evans when they started Sunday Assembly. SANDERSON JONES: It turns out there are loads of people out there who want to live better, help often and wonder more... BARCO: In an online crowd funding campaign video, the two British comedians talk about their idea for gathering self-proclaimed godless congregations. PIPPA EVANS: It's all the best bits of church but with no religion and awesome pop songs. JONES: It's a celebration of life. EVANS: And it's not a cult. SANDERSON JONES AND PIPPA: But that's exactly what we'd say if it were a cult. (SOUNDBITE OF EERIE MUSIC) BARCO: This lighthearted approach seems to be reaching a growing number of nonreligious people. PHIL ZUCKERMAN: This is a big now - a big boom of secularity. People not wanting to associate with religion, not wanting to identify as religious. BARCO: Phil Zuckerman teaches about secularism at Pitzer College in Southern California. He's also the author of the books "Faith No More" and "Society without God." He says his research shows that 20 percent of Americans today report being non-religious. And among Americans younger than 30 years old, that number is 30 percent. ZUCKERMAN: Some people who were raised with religion reject it for certain reasons that leaves them with a bitter taste in their mouth about religion. Either they had bad experiences in their church or they saw hypocrisy in the youth pastor, or they felt that their religion was manipulative - or all the litany of reasons people might not like religion. Those people are a little bit angry at religion. BARCO: But Zuckerman says Sunday Assembly appeals to the more optimistic atheists, those hoping to recreate what they felt was good about religion. ZUCKERMAN: They miss the community. They miss the music. They miss the multi-generational coming together with people that you might not otherwise be hanging out with. But they don't want to go to a place where they have to keep their intellect on hold. They don't want to push pause on the skepticism button, you know, in their mind. BARCO: Zuckerman notes that for years there have been secular organizations, like the Ethical Culture Society, American Atheists and various humanist centers. But he says unlike some of them, Sunday Assembly is not out to critique or debunk religion. DAVID HERNSTON: You know, I don't believe in God.

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consistent with a lot of art neuvea and deco touches, hand-painted texture work and a great attention to detail. Double Fine’s previous games have shown the same love, and it’s good to see they haven’t skimped just because it’s a cheaper, lower profile title. Each of the dolls has a lot of personality and the animation is spectacular considering the dolls have no posable arms, legs, or, well.. Anything! The sound is perfectly suited too, from the funny little noises the characters make, the steam and clattering of machinery. Perhaps the game would have benefitted from a little more music during gameplay? That’s probably just a personal preference. The music that IS there is in-fitting with the era and enhances the mood. Gameplay: Charlie is controlled from a standard 3rd person view (right stick pans camera) The game centres around a hub-world like train station, allowing you to revisit any levels to unlock extra rewards and mess around. As you complete each scenario a new platform or train becomes accessible in the station. Cleverly little shrines are built in the station documenting your progress throughout the game, complete with murals and a visual record of the dolls you’ve used. It’s a lovely little touch as it makes your achievements in the game seem much more tangible. I’d like to see this sort of thing in other games. Each level consists of a location, say a cruise ship – with a few main puzzles which can all be solved in multiple (usually 4+) ways. Each of the puzzles depends on clever use of each of the stacking dolls’ abilities. With more than 100 different dolls ranging from rats and mummies to socialites and musicians – each of the dolls has its own specific skill. Charlie can only stack into a doll of the next size up, and so on, so you find yourself shuffling around between different dolls, sometimes needing two dolls’ skills to complete a puzzle. The concept is pretty hard to explain, so here’s some gameplay in an official trailer. For old-timers – the core gameplay is similar to Paradroid, though much more accessible and with no danger of death/failure. As a result – the level of challenge in Stacking is.. Well, there isn’t really much of a challenge. It’s quite a stress free (casual?) experience. Running through the main story will likely not take you more than four hours in a single play-through. Most of the value comes from messing around and trying to think up new ways to solve each of the puzzles. Much of the dialogue and situations that play out as you interact with the dolls is very entertaining and well worth the extra time. There are even mini achievements labelled “hijinks” asking you to do lots of dumb things, rewarding you with prettified dolls. eg; you might have to head-butt 10 different dolls, or shake a lot of people’s hands. Conclusion: All in all as a complete package at a good price Stacking is a gem of a title as long as you don’t expect long term challenge. I enjoyed it thoroughly and it’s actually refreshing to be able to complete a game within a reasonable period of time, knowing I can dip back into it and unlock further stuff. This seems ideal for a downloadable title of this kind. It’s not so long it drags, but it could probably have done with some advanced challenges as an optional aside. Portal is a good example – a short puzzle game with an obvious progression through a pretty easy campaign with the hard challenges unlocked at the end. As it is, Stacking is not going to appeal to some players, though I’d urge you to try it out and support Double Fine’s original efforts. N.B: This month Stacking is FREE to members of PlayStation Plus, so obviously that’s worth downloading.. As for other buyers – if you like the style and think you’d enjoy the gameplay you’re not likely to find such a fun, if short diversion. Notes: Played once through the PS3 version. Still have to 100% all the unlockables and achievements. As far as I’m aware there is no difference between PS3 and ‘360 versions, so count the review as both.Forum and Social Media Guidelines – 2/26/13 The following are the guidelines for this Forum and all NACA social media, including Facebook, Twitter, NACA Radio and Live Chat: The following rules have always been posted near the top of the Forums page on the forum website at http://forums.naca.com, just above the links to the five forum categories: “Welcome to the NACA Forums! Please keep in mind that this is a public forum. Any derogatory, inflammatory or questionable content will be removed by administrators. Also, please DO NOT post any personal information, such as passwords, NACA ID numbers, or Social Security numbers; NACA Staff will never require this information on the Forums.” Disregard for the rules and other abuses of the forum and social media in general is not tolerated. Such activity hinders the effectiveness of the NACA social media efforts as tools for asking questions, sharing information and for those who are seeking help with problems in either the Home Save or Purchase programs. To prevent such abuses, the following rules apply for all NACA social media: F(orum) comes before E(mail): Maybe not in the alphabet, but here in the forum, F comes before E. In other words, please post your question in the Forum rather than circumvent the system and send an Email to an address you happen to find in the forum. The forum exists for several purposes, not the least of which is the sharing of information that may be beneficial to many of our members. Most of the questions we receive are more generic in nature than most people think. By posting a question in the Forum first, it can be most likely answered here in the Forum unless it involves specific information in your file. By handling the question or problem here whenever possible, other members experiencing a similar problem could get the answer and help they need more quickly and without making a single additional keystroke. If your post does require specific information, you will be advised on the best means of contact with us so any personal information can be communicated securely and confidentially. The NACA Live Chat function on the home page of the NACA website can also be used to securely ask specific questions regarding your file. The Forum Does Not Replace NACA Services: This Forum and other social media channels iare in no way a substitute for NACA Counseling and Advocacy services whether in the Home Save or Purchase Programs, and information found here should not be considered a replacement for communicating with a NACA counselor. While much of the information here is general in nature and applicable to most situations, specific questions regarding your file cannot be addressed in this or any other public forum for privacy reasons. Additionally, every file has unique factors and issues of its own. Therefore, you should always attempt to communicate your questions and concerns with your Mortgage Consultant in the Purchase Program and with a Counselor, Negotiator or Member Services rep in the Home Save program. Plus, the new NACA Live Chat function on the home page at www.naca.com allows you to contact a NACA staff member and communicate real-time to seek answers to your questions regarding your file. Our Member Services Department can be reached at 425-602-6222. The Member Services and Live Chat Teams are available from 8am to 10 pm Eastern Time Monday through Friday. Keep it Civil: Another serious issue is the tone used in some messages. We eagerly invite anyone who is having what they perceive to be any sort of problem with the NACA process or on line system to use this Forum and social media channels as a means of reaching out to us with those concerns so we can help solve them in whatever way we can. However, please remember to compose your message in the same manner in which you would like to receive the response. As noted above, “derogatory, inflammatory or questionable content” has always been grounds for posts to simply be deleted. This includes sarcasm as well as insulting and accusatory statements. The NACA Membership Agreement states that you agree to not engage “in any conduct deemed by NACA to be harmful, threatening, demeaning, or contrary to its interests, staff, mission and agents…”. Determination of what content is considered inappropriate is at the sole discretion of the administrators of the NACA Forum and other NACA social media channels. While we are in fact eager to help with any problems that may occur, if you can’t write without being cynical, you may want to hold off a bit until you can be more rational in expressing your concerns. No Personal Information: While this one should be common sense, it is surprising how many people will post their name, NACA ID number and even their telephone number in a forum post or even on Facebook. Please remember that what you write here can be read by anyone on the internet. This is not a membership-restricted site, so please do not post any information about yourself here that you would not announce over a microphone to a crowd of twenty thousand people. Again, that personal information starts with and includes your NACA ID number. Never post it or any other personal information in a public forum, here or anywhere else on the web. Oh, By the Way, Who Am I Talking To? Under other circumstances, this would actually be funny. We far too commonly receive emails from members who go to substantial effort to make sure they have provided a wonderfully detailed explanation of their problem or question

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in the white chair and listen to me play. She understood, more than any of the others, that I could play only the songs I had copied from Kovich. Jewell, to the end, thought I could read music, and Taber even brought me hardcopies from Solfatara. Pearl simply said the names of songs, and I played them if I knew them. She never asked for one I didn't know, and I thought that was because she listened carefully to the tappers' requests and my refusals, and I was grateful. I sat down at the pianoboard and looked at Pearl in the mirror. I had asked Jewell for the mirror so I could see over my shoulder. I had told her I wanted it so she could signal me songs and breaks and sometimes the ropecutter if the men got rough or noisy, but it was really so I could keep Taber from standing there without my knowing it. "'Back Home,'" Pearl said. I could hardly hear her over the nitrogen blowers. I began playing it, and Taber came in. He walked swiftly over to her and then stood quite still, and between my playing and the noise of the blowers, she did not hear him. He stood about half a meter from her, close enough to touch her but just out of reach if she had put her hand out to try to find him. He took the cigar out of his mouth and bent down as if he were going to speak to her, and instead he pursed his lips and blew gently at her. I could almost see the smoke. At first she didn't seem to notice, but then she shivered and drew her shinethread shawl closer about her. He stopped and smiled at her a moment and then reached out and touched her with the tip of his cigar, lightly, on the shoulder, as if he intended to burn her, and then darted it back out of her reach. She swatted at the air, and he repeated the little pantomime again and again, until she stood and put her hands up helplessly against what she could not see. As she did so, he moved swiftly and silently to the door so that when she cried out, "Who is it? Who's there?" he said in his slow drawl, "It's me, Pearl. I've just come in. Did I frighten you?" "No," she said, and sat back down again. But when he took her hand, she flinched away from him as I'd thought she would from me. And all the while I had not missed a beat of the song. "I just came over to see you for a minute," Taber said, "and to hear your pianoboard player. He gets better every day, doesn't he?" Pearl didn't answer. I saw in the mirror that her hands lay crossed in her lap again and didn't move. "Yes," he said, and walked toward me, flicking imaginary ashes from his unlit cigar onto my hands. "Better and better," he said softly. "I can almost see my face in you, Mirror." "What did you say?" Pearl said, frightened. "I said I'd better go see Jewell a minute about some business and then get back next door. Jack found a new hydrogen tap today, a big one." He went back through the card room to the kitchen, and I sat at the pianoboard, watching in the mirror until I saw the kitchen door shut behind him. "Tabar was in the room the whole time," I said. "He was... doing things to you." "I know," she said. "You shouldn't let him. You should stop him," I said violently, and as soon as I said it I knew that she knew that I had not stopped him either. "He's a very bad man," I said. "He has never locked me in," she said after a minute. "He has never tied me up." "He has never known how before," I said, and I knew it was true. "He wants me to find out for him." She bent her head to her hands, which still lay crossed at the wrists, almost relaxed, showing nothing of what she was thinking. "And will you?" she said. "I don't know." "He's trying to get you to copy him, isn't he?" she said. "Yes." "And you think it's working?" "I don't know," I said. "I can't tell when I'm copying. Do I sound like Taber?" "No," she said, so definitely that I was relieved. I had listened to myself with an anxious ear, hoping for Jewell's shortened vowels and tapper slang, waiting in dread for the slow, lazy speech of Taber. I did not think I had heard either of them, but I had been afraid I wouldn't know if I did. "Do you know who I'm copying?" I said. "You walk like Jewell," she said, and smiled a little. "It makes her furious." It was the end of the shift before I realized that, like my uncle, she had not really answered what I had asked. Jack's new tap turned out to be so big that he needed a crew to help put up the compressors, and for several shifts hardly anyone was in the house, including Taber. Because business was so slack, Jewell even let some of the girls go over to the gaming house. Taber didn't go near the tap, but he didn't come over quite so often either, and when he did, he spent his time upstairs or with Carnie, talking to her in a low voice and clicking the speaker over and over again, as if he could not help himself. Then, once the compressors were set up and the sidon working, the men poured back into St. Pierre, and Taber was too busy to come over at all. The one time he came, he found Pearl alone with me, he said, "It's Taber, Pearl," almost before I had banged a loud chord on the keys and said, "Taber's here." He did not have his cigar with him, or his sparker, and he did not even speak to me. Watching Pearl talk to him, her head gracefully turned away from him, her hands in her lap, I could almost believe that he would not succeed, that nothing could hurt her, safe in her blindness. We were so busy that Jewell hardly spoke to me, but when she did, she told me sharply that if I had nothing better to do than copy her, I should tend bar, and set me to passing out the watered liquor she had brought out in honor of the new sidon. She did the boards for the week herself while I ran the body checks. Pearl, naked under the scan, looked serene and unhurt. Carnie had sot-scars under her arms. I did not report her. If Jewell found out, she would send Carnie back to Solfatara, and I wanted Tabor to be working on Carnie, giving her sots and trying to get her to help him, because then I could believe he had given up on me. I did not dare believe that he had given up on Pearl, but I did not think that he and Carnie alone could hurt her, no matter what they did to her. Not without my help. Not so long as I was copying Jewell. I told Pearl about Carnie. "I think she's on sots," I said. We were alone in the music room. Jewell was upstairs, trying to catch up the boards. Carnie was in the kitchen, taking her turn at supper. "I saw what looked like scars." "I know," Pearl said, and I wondered if there was anything she did not see, in spite of her blindness. "I think you should be careful. It's Taber that's giving them to her. He's using her to hurt you. Don't tell her anything." She said nothing, and after a minute I turned back to the pianoboard and waited for her to name a song. "I was born in the happy house. My mother worked there. Did you know that?" she said quietly. "No," I said, keeping my hands spread across the keyboard, as though they could support me. I did not look at her. "I have told myself all these years that as long as no one knew what happened, I was safe." "Doesn't Jewell know?" She shook her head. "Nobody knows. My mother told them he threatened her with the sot-razor, that there was nothing she could do." The nitrogen blowers kicked on just then, and I jumped at the sound and looked into the mirror. I could see the sidon in the mirror, and standing on its red murdered skin, Taber. Carnie had let him in through the kitchen and turned the blowers up, and now he stood between the noisy blowers, smiling and flicking imaginary ash onto the carpet beside Pearl's chair. I took my hands off the keyboard and laid them in my lap. "Carnie's in the kitchen," I said. "I don't know if the door's shut." "There was a tapper who came to the house," Pearl said. "He was a very bad man, but my mother loved

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-fn"}^ 31/173 1.0 11/173 1.0 23/173 1.0 CC 28/160 0.6 (0.4--1.1) 9/160 0.4 (0.1--1.1) 21/160 0.7 (0.4--1.2) *hsa-mir*-499 rs3746444 CT + CC 29/154 1.0 12/154 1.0 21/154 1.0 TT 30/179 0.6 (0.3--1.1) 8/179 0.5 (0.2--1.2) 23/179 0.8 (0.4--1.3) Patients treated with chemoradiation (*N* = 663) *hsa-mir*-146a rs2910164 CG + CC^[b](#tfn_007){ref-type="table-fn"}^ 103/306 1.0 67/303 1.0 86/306 1.0 GG 132/357 1.0 (0.8--1.3) 65/360 0.8 (0.5--1.1) 94/357 0.9 (0.7--1.2) *hsa-mir*-196a2 rs11614913 CT + TT^[b](#tfn_007){ref-type="table-fn"}^ 124/369 1.0 70/366 1.0 94/369 1.0 CC 111/294 1.1 (0.9--1.4) 62/297 1.0 (0.8--1.4) 86/294 1.0 (0.8--1.3) *hsa-mir*-149 rs2292832 CT + TT^[b](#tfn_007){ref-type="table-fn"}^ 136/337 1.0 72/332 1.0 102/337 1.0 CC 99/326 0.6 (0.3--0.8) 60/331 0.7 (0.5--1.0) 78/326 0.6 (0.3--0.9) *hsa-mir*-499 rs3746444 CT + CC^[b](#tfn_007){ref-type="table-fn"}^ 133/298 1.0 68/293 1.0 94/298 1.0 TT 102/365 0.6 (0.4--0.9) 64/370 0.5 (0.4--0.8) 86/365 0.5 (0.3--0.7) Adjusted for age, sex, ethnicity, smoking status, alcohol use status, stage, and comorbidity. Reference group. DISCUSSION {#s3} ========== Our results demonstrate the association between certain pre*-miRNA* polymorphisms and survival among patients with SCCNOP. We found that patients with the *hsa-mir*-149 CC and *hsa-mir*-499 TT genotypes had a significantly lower risk of death and disease recurrence than did patients with the corresponding variant genotypes. Furthermore, we found that these significant associations were restricted to the patients who were ever smokers and the patients treated with radiation and/or chemotherapy with or without surgery. These results suggest that the *hsa-mir*-149 and *hsa-mir*-499 polymorphisms predict prognosis in patients with SCCNOP, particularly in some subgroups, which may help physicians develop individualized treatment plans that improve survival and quality of life for patients with this disease. If the associations between these polymorphisms and SCCNOP death and disease recurrence are confirmed, clinicians could use these functional polymorphisms as biomarkers to identify an important subgroup of patients who are at high risk of death or recurrence. It is likely that future targeted therapies will be designed (in part) to counteract the effects of significant SNPs as well as individualized within the SCCNOP subgroup. Furthermore, it may be possible to intensify treatment for patients in whom the adverse genotypes are identified before treatment begins, add adjuvant therapy for those with such adverse genotypes identified immediately after treatment, and intensify the workup for treatable recurrent disease or in those who are found to have a high risk of death and recurrence in follow-up. However, these potential therapeutic options would each have to be tested in clinical trials. While local or distant recurrent SCCNOP is almost always ultimately fatal, it is hoped that the earlier recurrent disease is detected the greater the chances of successfully treating such disease. Ultimately, the data from studies such as this one will improve prognostication, facilitate more selective use of systemic therapy, and hopefully, improve outcomes. It has been demonstrated that some *miRNAs* are upregulated in head and neck cancer cell lines and tumors, and high expression levels of these genes may be associated with cancer progression and poor outcomes \[[@R16], [@R17]\]. However, other *miRNAs* appear to be down-regulated, and their reduced expression may contribute to the development and/or progression of such cancers by coordinating a loss of sensitivity to ionizing radiation \[[@R18]\]. Therefore, *miRNA* expression patterns could be powerful biomarkers for the diagnosis and prognosis of head and neck cancers \[[@R17]\]. Genetic polymorphisms of *miRNAs* are one of the most important genetic alterations and are capable of causing reductions or increases in *miRNA* expression levels, and in turn, individual variations in the regulation of inflammatory and apoptotic responses \[[@R19]\]. Studies have suggested that *miRNAs* are critical in mediating inflammatory response *in vitro* and *in vivo* \[[@R20]\]; and they have both anti-inflammatory and pro-inflammatory actions through the regulation of inflammatory signaling pathways, targeting key elements in the pathways for the regulation of inflammatory responses to cytotoxic therapy, including chemoradiotherapy \[[@R20]\]. Functional analyses also have indicated that *miRNAs* are involved in the regulation of inflammatory responses and cytokine signaling \[[@R21]\]. On the other hand, *miRNAs* influence apoptosis through their regulation of both intrinsic and extrinsic apoptotic pathways and oncogenic and tumor suppressor networks \[[@R22]\]. Therefore, genetic alterations of *miRNAs* may lead to evasion of apoptosis, a mechanism that possibly leads to tumorigenesis by influencing apoptosis and cell-survival pathways through resistance to radiation. Evasion of apoptosis also may dictate the evolution of neoplastic cells. Given the roles of *miRNAs* as regulators of apoptosis, it is likely that *miRNAs* modulate sensitivity/resistance to radiation therapy in SCCNOP patients. Several studies have investigated the associations between the 4 *miRNA* polymorphisms in this study and cancer risk and prognosis \[[@R11], [@R12], [@R23]--[@R26]\], but none have investigated whether these 4 polymorphisms are associated with survival in SCCNOP patients. An association between *miRNA* polymorphisms and cancer risk and prognosis is well supported by several lines of evidence. First, our previous study suggested that these 4 *pre-miRNA* polymorphisms may have a joint effect on the risk of SCCHN \[[@R27]\]. The SNPs located within either the pre*-miRNAs* or the *miRNA* binding sites are in theory most likely to affect the expression of the *miRNA* targets contributing to cancer susceptibility and prognosis \[[@R23], [@R24]\]. Studies have evaluated the association between these same 4 SNPs and survival in cancer patients and found that *hsa-mir*-196a2 rs11614913 CC was significantly associated with decreased survival in non-small cell lung cancer and squamous cell carcinoma of the oropharynx (SCCOP) \[[@R11], [@R13]\]. Our previous study and others also showed that both *hsa-mir*-146a rs2910164 and *hsa-mir*-196a2 rs11614913 were significantly associated with survival in SCCOP patients \[[@R13]\]. However, in the current study, such an association was not found in SCCNOP for these 2 SNPs, and we found instead that the *hsa-mir*-149 and *hsa-mir*-499 polymorphisms were significantly associated with survival in SCCNOP. The mechanisms by which different pre-*miRNAs* and their target mRNAs regulate progression in different types of cancer could be different, and the subject warrants further study. For example, SCCOP is mainly driven by HPV infection, whereas SCCNOP is caused by smoking \[[@R13]\]. Although we do not know how these pre-*miRNA* variants influence the survival of SCCNOP, it is biologically plausible that these variants are either functional or in linkage disequilibrium with other functional variants of *miRNAs* or alleles at other nearby susceptibility loci. Such functional variants could increase or reduce *miRNA* expression levels and thus affect the regulation of inflammation and apoptotic responses. The altered regulation in these pathways might enable many cancer cells to escape or counterattack the inflammatory and apoptotic responses, leading to individual variations in inflammatory/apoptotic responses to chemoradiotherapy. The significant association was found in ever smokers but not in never smokers. This finding can be explained by the direct effect of tobacco smoking on both pro-inflammatory and immunosuppressive responses \[[@R28]--[@R30]\], which will influence the host response to treatment and thus affect the risk of death and disease recurrence. Smoking also has an

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(x_1,x_2,p)=1/2x_1^2+1/2x_2^2+p(x_1+x_2-1)$. Assuming that the agent $1$ is the leader in the Stackelberg game and others are followers, reaction curves are given by $x_2(x_1)=1-x_1$ and $p(x_1)=x_1-1$. Hence, suppose that agent $1$ takes a strategy to follow the following update rule instead of (\[ahu\]): $$\label{algleader} \hat{x}_1^k=\hat{x}_1^{k-1}-\gamma \frac{d}{d\hat{x}_1}u_1(\hat{x}_1,p(\hat{x}_1)).$$ With other players remaining to follow (\[ahu\]), the new dynamics leads to a Stackelberg equilibrium $(x_1^*,x_2^*, p^*)=(1/3,2/3,-2/3)$. Notice that player $1$ achieves a smaller augmented cost $u_1^*=-1/6$ at the new equilibrium, even though the distributed algorithm as a whole clearly failed to find the solution to the original resource allocation problem. In this sense, the strategy of following (\[ahu\]) by no means constitutes a Nash equilibrium. Faithful implementation of dual decomposition ============================================= We are going to introduce a monetary transfer function $t$ that incentivises followers to implement (\[ahu\]). For a sufficiently large $K$, a social decision $$x:=\hat{x}^K-R^T(RR^{T})^{-1}(R\hat{x}^K-c)$$ approximates the optimal solution of (\[originalprob\]) with an arbitrary accuracy. A natural choice of $t_i$ inspired by the Groves mechanism is then $$\label{grovestax} t_i:=\sum_{j\neq i} v_i(x_i;\theta_i).$$ Throughout the algorithm, we require the followers to report not only $x_i^k$ but also the value $v_i(x_i^k;\theta)$ so that the leader is able to perform a convergence analysis and compute $t_i$. The proposed distributed algorithm is summarized in Algorithm \[distalg\]. Note that the algorithm is parametrized by $n\in \mathbb{N}$, which guarantees the accuracy $1/n$ of the final result. \[distalg\] $\text{Problem data, step size $\gamma$ }$ $\text{Social outputs } \tilde{x}, \tilde{t}_1,\cdots,\tilde{t}_N$ $\text{(F) Initialize } \hat{x}_1, \cdots, \hat{x}_N;$ $\text{(L) Initialize and broadcast } p \text{ and } x;$ $\text{(F) Compute and report } v_i=v_i(x_i; \theta_i);$ $\text{(F) Find } \hat{x}_i=\operatorname*{arg\,min}_{x_i}(v_i(x_i;\theta_i)+p^TR_ix_i)$ $\text{ and report } \hat{x}_i \text{ and } \hat{v}_i=v_i(\hat{x}_i;\theta_i);$ $\text{(L) Compute upper bound } \bar{b}=\sum_{i=1}^N v_i;$ $\text{(L) Compute lower bound } \underbar{b}=\sum_{i=1}^N(\hat{v}_i+p\hat{x}_i);$ $\text{(L) Compute constraint violation } e=R\hat{x}-c;$ $\text{(L) Update dual variable } p:=p+\gamma e;$ $\text{(L) Find nearest feasible point } x=\hat{x}-R(RR^T)^{-1}e;$ $\text{(L) Broadcast } p \text{ and } x;$ $\text{(L) Determine social decision } \tilde{x}=x;$ $\text{(L) Determine tax values }\tilde{t}_i=\sum_{j\neq i} v_i;$ Note that Algorithm \[distalg\] suggests followers’ strategies $s^n(\cdot)$ and a social output function $g^n=(\tilde{x}^n,\tilde{t}^n)$. One possible state space description of the follower’s strategy $$s_i(\theta)=\left\{(G_{i,\theta_i}^k, H_{i,\theta_i}^k): k=1,2,\cdots,K(n)\right\}.$$ is obtained by considering $y_L=(p; x)$ as the leader’s output and \[statespace\] $$\begin{aligned} &\underbrace{\left[\begin{array}{c} v_i \\ \hat{x}_i \end{array}\right]}_{z_i^k}= \underbrace{\left[\begin{array}{c} v_i(x_i) \\ \operatorname*{arg\,min}_{x_i} \left(v_i(x_i)+p^TR_ix_i\right) \end{array}\right]}_{G_{i,\theta_i}^k(z_i^{k-1},y_L^{k-1})} \\ &\underbrace{\left[\begin{array}{c} v_i \\ \hat{x}_i \\ \hat{v}_i \end{array}\right]}_{y_i^k}= \underbrace{\left[\begin{array}{c} v_i \\ \hat{x}_i \\ v_i(\hat{x}_i;\theta_i) \end{array}\right]}_{H_{i,\theta_i}^k(z_i^k)}.\end{aligned}$$ The number of steps $K(n)$ is not known a priori but is finite. The strategy space $\Sigma_i^n$ for the $i$-th follower is the space of causal mappings from $y_L^0,\cdots,y_L^{K(n)}$ to $y_i^0,\cdots,y_i^{K(n)}$. This way Algorithm \[distalg\] defines a sequence of mechanisms $\{M_n\}_{n\in \mathbb{N}}$, $M_n=(g^n,\Sigma^n,s^n)$. Notice that the payment $t$ obtained in Algorithm \[distalg\] is only an approximation of the correct VCG payment because, as per (\[grovestax\]), it is computed using the final value of $x$, as opposed to the optimal social decision. Hence generally it does not guarantee incentive compatibility in the sense of Definition \[defic\]. Such a fragile aspect of the VCG mechanism is considered in [@RefWorks:108]. \[defaic\] A sequence of mechanisms $\{M_n\}_{n\in\mathbb{N}}$, $M_n=(g^n,\Sigma^n,s^n)$ is said to *asymptotically implement* a social choice function $f$ in ex-post Nash equilibria if for every $\delta_1>0,\delta_2>0$, there exists $N\in\mathbb{N}$ such that for any $n\geq N$, - $\|g^n\circ s^n-f\|<\delta_1$ - $\forall i, \forall \hat{s}_i^n\in\Sigma_i^n, \forall \theta\in \Theta$, $$\begin{aligned} &\hspace{-.2in}v_i\left(\tilde{x}_i^n\circ (s_i^n(\theta_i),s_{-i}^n(\theta_{-i})));\theta_i\right) +\tilde{t}_i^n\circ (s_i^n(\theta_i),s_{-i}^n(\theta_{-i})) \\ &\hspace{-.2in}< v_i\left(\tilde{x}_i^n\circ (\hat{s}_i^n,s_{-i}^n(\theta_{-i}));\theta_i\right) +\tilde{t}_i^n\circ (\hat{s}_i^n,s_{-i}^n(\theta_{-i})) +\delta_2.\end{aligned}$$ In this case, $\{M_n\}_{n\in\mathbb{N}}$ is said to be *asymptotically incentive compatible*. For a fixed $n\in \mathbb{N}$, $M_n$ is not incentive compatible. However, as $n\rightarrow \infty$, $M_n$ provides every follower a diminishing incentive to deviate from the suggested slave algorithm. \[tho:1\] Assume that $v_i(\cdot;\theta_i), i=1,2,\cdots,N$ are strictly convex for every $\theta_i\in\Theta_i$, and define a social choice function $f=(x,t)$ by $$\begin{aligned} & x:\Theta\rightarrow X, x(\theta)=\operatorname*{arg\,min}_{x_1,\cdots,x_N} \sum_{i=1}^N v_i(x_i;\theta_i) \\ & t:\Theta\rightarrow \mathbb{R}^n, t_i(\theta)=\

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hat r}_i \rangle \langle \Delta {\hat r}_j \rangle ,$$ with ${\hat r}_i \in \left\{{\hat X}_1,{\hat P}_1,{\hat X}_2,{\hat P}_2,\cdots,{\hat X}_{M+N},{\hat P}_{M+N} \right\}$ and $\Delta {\hat r}_k={\hat r}_k-\langle {\hat r}_k \rangle$. $ \gamma_{A} $ and $\gamma_{B}$ are $2M \times 2M $, $2N \times 2N $ real symmetric positive matrices representing local statistics of $M$- and $N$-modes, respectively. $C$ is a $ 2M \times 2N $ real matrix representing correlation between two subsystems. Due to the uncertainty principle, the covariance matrix must satisfy $\gamma_{AB} \pm i \Omega_{AB} \geq 0$, where $ \Omega_{AB} =\oplus_{i=1}^{M+N} \left( \begin{array}{cc} 0 & 1 \\ -1 & 0 \\ \end{array} \right) $ is the sympletic form [@Simon]. For the case of a two-mode Gaussian state, the covariance matrix can always be brought to a standard form by local Gaussian operations [@Duan00; @Simon00] $$\label{scova} \gamma _{AB} = \left( \begin{array}{cc} \gamma_A & C \\ C^T & \gamma_B \\ \end{array} \right) = \left( \begin{array}{cccc} a & 0 & c_1 & 0 \\ 0 & a & 0 & - c_2 \\ c_1 & 0 & b & 0 \\ 0 & - c_2 & 0 & b \\ \end{array} \right) .$$ Without loss of generality, we may set $ c_1 \geq \left| c _2 \right| \geq 0 $.\ Under Gaussian measurements, a Gaussian state $ \rho_{AB} $ is non-steerable from $B$ to $A$ iff $$\label{GC} {\gamma _{AB}} + i{\Omega _A}\oplus{{\bf 0}_B} \ge 0,$$ where $ {\bf 0}_{B} $ is a $ 2N \times 2N $ null matrix [@Wiseman07]. We now introduce our non-Gaussian steering criterion based on a set of local orthogonal observables, which we use to detect the steerability of two-mode Gaussian states. [**Lemma**]{}: Let us choose a collection of $n^2$ observables $\left\{ A^{(n)} \right\} = \left\{ \lambda_k,\, \lambda_{kl}^{\pm} \right\}$ $\left( k,l=0,1,...,n-1 \right) $ where $$\begin{aligned} \lambda_k&=& |k\rangle \langle k |\\ \lambda_{kl}^{+}&=&\frac{|k \rangle \langle l| +|l \rangle \langle k| }{\sqrt{2}}\,\, \left( k < l \right), \\ \lambda_{kl}^{-}&=&\frac{|k \rangle \langle l| -|l \rangle \langle k| }{\sqrt{2}i}\,\, \left( k <l \right). \end{aligned}$$ Here $ |k \rangle $ refers to a Fock state of number $k$. Note that each of $\lambda_k$ and $\lambda_{kl}^{\pm}$ represents a complete projective measurement individually. That is, $\lambda_k$ represents a two-outcome projective measurement, assigning $+1$ if the tested state is detected in $|k\rangle$ and $0$ otherwise. On the other hand, $\lambda_{kl}^{\pm}$ represents a three-outcome projective measurement, assigning $\pm1$ if detected in the two eigenstates of $\lambda_{kl}$ and 0 otherwise. These observables satisfy the orthogonal relations $ \operatorname{Tr}\left( A_i^{(n)} A_j^{(n)} \right) =\delta_{ij}$ and the sum of variances must satisfy the uncertainty relation, $$\label{LUR1} \sum_j \delta^2\left( A_j^{(n)} \right) \geq \left(n-1 \right) \langle {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n \rangle,$$ where $\delta^2\left(A_j^{(n)}\right)= \langle \left(A_j^{(n)}\right)^2 \rangle-\langle A_j^{(n)} \rangle^2$ represents each variance and $ {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n = \sum_{k=0}^{n-1} |k \rangle \langle k | $ the projection to the Hilbert space of truncated $n$-levels. The proof of Lemma is given in Supplementary Information.\ \ Now consider an orthogonal $n^2 \times n^2$ matrix $ O_n $ in the truncated space, satisfying $ O_n^T O_n= O_n O^T_n = {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n$. Then the set of observables $ \left\{ \tilde{A}_j^{(n)} \right\}$ under the transformation $\tilde{A}_j^{(n)} = \sum_l O_{jl} A_l^{(n)}$ also satisfies the uncertainty relation in equation (\[LUR1\]) since $ \sum_{j} \left( \tilde{A}_j^{(n)} \right)^2 = \sum_{j,l,l'} O^T_{lj}O_{jl'} A_l^{(n)}A_{l'}^{(n)}=\sum_l \left(A_l^{(n)}\right)^2 =n {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n$ and $ \sum_j \langle \tilde{A}_j^{(n)} \rangle^2 = \sum_{j,l,l'} O^T_{lj}O_{jl'}\langle A_l^{(n)} \rangle\langle A_{l'}^{(n)} \rangle = \sum_l \langle A_l^{(n)} \rangle^2 $. This invariance property will be used later.\ \ We now obtain a non-steering condition based on these orthogonal observables.\ \ [**Theorem**]{}: If a two-mode quantum state $\rho_{AB}$ is non-steerable from B to A, it must satisfy the inequality $$\label{LUR-steer} \sum_j \delta^2 \left( A_j^{(n)} \otimes {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}+ g {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}\otimes B_j^{(n')} \right) \geq \left(n-1 \right)\langle {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n^{A} \rangle,$$ for any real $g$, where the observables $ \left\{ A_j^{(n)} \right\} $ satisfy the uncertainty relation in Eq. (\[LUR1\]). Its proof is given in Supplementary Information.\ \ We next introduce a useful criterion originating from the inequality (\[LUR-steer\]) that can be readily computable.\ \ [**Proposition**]{}: If a two-mode state $ \rho_{AB}$ is non-steerable from $B$ to $A$, the correlation matrix $ C_{nn'}^{TLOOs}$ with elements $\left( C_{nn'}^{TLOOs} \right)_{ij}\equiv\langle A_i^{(n)} \otimes B_j^{(n')} \rangle-\langle A_i^{(n)} \rangle\langle B_j^{(n')} \rangle$ constructed with $n$- and $n'$-level truncated local orthogonal observables (TLOOs) must satisfy ($ \|\,\cdot\|_{tr}$: trace norm) $$\begin{aligned} \label{steering-tr} &&\| C_{nn'}^{TLOOs} \|_{tr} \nonumber\\ &&\leq \sqrt{ \left( \langle {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_n^{A} \rangle -\sum_{j=1}^{n} \langle A_j^{(n)} \rangle^2 \right) \left( n' \langle {\leavevmode\hbox{\small1\kern-3.8pt\normalsize1}}_{n'}^B \rangle - \sum_{j=1}^{n'} \langle B_j^{(n')} \rangle^2 \right)}.\nonumber\\\end{aligned}$$ The proof of Proposition in Supplementary Information clearly shows that if a given state violates the inequality (\[steering-tr\]), it is steerable from B to A, and also that there exist a set of TLOOs that violates the inequality (\[LUR-steer\]) as well. We give some details on how to calculate the expectation values of TLOOs for a given state in Supplementary Information. ![Detection of steerability for a lossy Gaussian state based on the criterion in equation

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if it failed to comply with an applicable government statute or regulation. Id. Sec. 403(2). We assume that a product's failure to conform to the state of the art at the time of its sale is evidence of a defect, although that failure does not rise to a presumption. 18 These provisions set the stage for proof of the state of the art at the time of the sale of the product. In order to prove the state of the art, evidence of what other manufactures are doing is clearly relevant and admissible. Section 13-21-404, the statute at issue in this case, is not addressed to subsequent remedial measures by the manufacturer, but appears instead to cover scientific advancements made by anyone where such advancements were "discovered" subsequent to the time the defendant manufacturer sold the product in issue. Read together with section 13-21-403, the Colorado legislature was merely establishing in section 13-21-404 that subsequent scientific advancements are the flip side of the state of the art at the time of sale, i.e., that if the design change or warning technique was not scientifically known at the time of the sale and therefore not state of the art, it is simply not relevant to whether the product was defective. On the other hand, a subsequent scientific advancement is relevant to a manufacturer's duty to warn its previous purchasers, and therefore it is admissible to show such a duty. 19 Subsequent to the enactment of section 13-21-401 to 405, the Colorado legislature adopted its own identical version of Fed.R.Evid. 407. The Committee Comment states: "The phrase 'culpable conduct' is not deemed to include proof of liability in a 'strict liability' case based on defect, where the subsequent measures are properly admitted as evidence of the original defect. But see Sec. 13-21-404, C.R.S. 1973 (1978 Supp.)." Colorado Rule of Evidence 407, Vol. 7B Colo.Rev.Stat. (1982 Supp.) (emphasis added). Following the two earlier Colorado court decisions in Roberts v. May, 41 Colo.App. 82, 583 P.2d 305 (1978), and Good v. A.B. Chance Co., 39 Colo.App. 70, 565 P.2d 217 (1977), the Colorado legislature chose to make Rule 407 inapplicable to products liability cases. The Comment establishes that the legislature contemplated the admission of some kinds of subsequent remedial measures in products liability cases, the exception being the limitation set out in section 13-21-404. 20 We read section 13-21-404 the way we do in part because it makes no sense that evidence of subsequent remedial measures would be admissible in Colorado to show feasibility in negligence cases, but not admissible in products liability cases under defendant's reading of the section. In our view, feasibility of alternative design is one way of establishing state of the art, proof of which is definitely contemplated by section 13-21-403. 21 Reading section 13-21-404 the way we do, we are of the view that the burden is upon the person who wants to muffle evidence to show that the advancement in question was "discovered" subsequent to the time of the sale. Here defendant argued that the section precluded admission of any subsequent remedial measure except to show duty to warn. Although defendant might have been able to make a case for application of section 13-21-404 to the valve design change that Heil patented, defendant failed to distinguish between that "subsequent discovery" and changes in the length of the shroud or use of a safety brace that were probably within the state of the art in 1972. Since defendant failed to show grounds for the application of the Colorado statute, and since 407 does not exclude this evidence, it is admissible under Rule 402. 22 The Decedent's Possession of Drug Paraphernalia 23 In the course of their investigation, the police inventoried Mr. Meller's personal possessions found at the scene of the accident. They discovered two hashish pipes containing marijuana residue in his rucksack. However, they found no evidence that he had used marijuana immediately before the accident. 24 Heil sought to admit the hashish pipes at trial, claiming that they were probative of the decedent's life expectancy and that they impeached prior testimony by the plaintiff. The district court excluded the pipes, concluding that their probative value was substantially outweighed by the danger of unfair prejudice. See Fed.R.Evid. 403. We agree. Heil provided no medical foundation for its claim that Mr. Meller's life expectancy was diminished by drug use. Furthermore, the pipes were of questionable value as impeachment material. Indeed, the testimony Heil sought to impeach involved statements of questionable admissibility that Heil itself had elicited.9 It appears that Heil sought to introduce the hashish pipes for the specific purpose of arousing juror sentiment against the decedent. The district court clearly acted properly in excluding this evidence. Product Misuse 25 At the close of trial, Heil requested that the jury receive an instruction explaining the defense theory of product misuse. The court denied the request and concluded that the elements of the defense were absent in this case. The court did instruct the jury on the defense theory of assumption of risk; however, Heil argues that it was entitled to an instruction on product misuse as well. 26 Heil's product misuse defense is, in essence, that Mr. Meller caused his own death by choosing to position himself under the dump bed while greasing the truck chassis. As Heil recognizes, the product-misuse defense requires a showing that injury was caused by the dangerous misuse of a product in a manner that could not reasonably have been anticipated by the manufacturer. E.g., Kinard v. Coats Co., 37 Colo.App. 555, 553 P.2d 835, 837 (1976). The defense protects the manufacturer who, in designing a product for a particular use, incorporates safety measures consonant with the full range of foreseeable applications. It recognizes that neither fairness nor the goals of enterprise liability are furthered by assessing liability for injuries arising out of unforeseeable applications of the product. See generally W. Prosser, Torts 641-82 (4th Ed.1971). 27 Viewing the defense in this light, it would be a misapplication of language and law to describe Mr. Meller's accident as a result of product misuse. Mr. Meller was performing routine maintenance on the dump truck. To perform the maintenance, he had to work in close proximity to the dump bed assembly. Heil offered no substantial evidence that it could not reasonably foresee Mr. Meller's contact with a part of the dump bed assembly. Indeed, the record contains abundant evidence that Heil should have anticipated the likelihood that a person might place himself between the chassis and the dump bed and thereby encounter the obvious dangers associated with the trip cable. The court wisely declined to exhibit before the jury a defense theory that was unclothed by supporting facts. See Smith v. Mill Creek Court, Inc., 457 F.2d 589, 592 (10th Cir.1972); Radio Corp. of America v. KYFM, Inc., 424 F.2d 14, 19 (10th Cir.1970). Given the evidence adduced at trial, the court acted within its authority in denying the request for an instruction on product misuse. The district court properly distinguished the defense of assumption of risk, a defense that the jury rejected. 28 Sufficiency of the Evidence to Support the Verdict 29 The jury awarded the plaintiff $400,000 in damages (prior to addition of interest and costs), which represented Mr. Meller's discounted future earnings. Heil claims that this award is excessive, citing "an extremely unstable and irregular work background." Principal Brief for Appellant at 43. 30 At trial, the plaintiff's expert witness, an economist at Colorado State University, testified that the present value of the decedent's future earnings was $580,300.00. Heil had ample opportunity to rebut this testimony and, indeed, argued vigorously to the jury that the estimate was excessive. It appears that the jury, in exercising its duties as a finder of fact, gave substantial credence to the expert testimony. We conclude that the verdict is consistent with the evidence presented and represents a reasonable award of damages. 31 The Bill of Costs and Interest on the Judgment 32 The district court entered a judgment against Heil for $431,024.13 and assessed Heil with the costs of trial. The plaintiff cross-appeals from the judgment, claiming that the court erred in its calculation of the bill of costs and interest on the verdict. 33 The plaintiff claims that the court erred in excluding certain deposition and expert witness fees in the bill of costs. The plaintiff acknowledges that the award of costs is within the trial court's discretion. See True Temper Corp. v. CF & I Steel Corp., 601 F.2d 495, 509 (10th Cir.1979). We might, on occasion, question a court's decision to award no costs to a prevailing party. See id. We will defer broadly, however, to a district court's determination that certain elements of the bill of costs are not recoverable. The calculation of costs is too closely bound to the conduct of the trial to permit second guessing from the appellate bench. We therefore reject the plaintiff's demand for additional costs. 34 The plaintiff also claims that she is entitled to additional

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." " I brought your pillow." " Thank you." " Is it hot?" " Yeah, a little." " I'm so happy to see you." " Me, too." "I brought your toothbrush and your phone." " The charger?" " Shoot, I forgot." "It's OK." "So how's your foot?" "It's really swollen." "The nurse said it's normal." "The doctor is coming." "Can you get some crutches?" "We'll walk around." "Good idea." "OK." "See you." "Where are we?" "Luxembourg." "Why'd you leave the highway?" "To fill up." "There's a gas station." " Shit!" "It's closed." " Yes." "We went 10 miles out of our way, and it's closed." "Should I even bother asking if you want me to drive?" "Millions of women drive." "That's the problem." "Still macho, I see." "Should we stop to eat?" "No." "Give me a sandwich." "Thanks." "It's good." "So what's the problem with the insurance?" "It's easy, no one wants to cover the accident." "Not Global, not the supplemental, or the mutual fund." "Because he was abroad over 3 months." "And the snow card?" "It even covers accidents off the slopes." "Guess what, he didn't have one." "That's just great." "Is he dumb?" "Yes..." "Kids think accidents only happen to other people." "OK, but?" "his employer should cover it." "No." "His contract ended 2 days ago." "Well, bravo!" "Water, please." "Thanks." "You think he'll be able to ski?" "I hope." "When he was 12 he said, "I like white, I like snow." ""I'll be a ski instructor."" "That's from you." "I know." " Do you regret it?" " No, he loves what he does." "But I'd worry less if he were a chess master." "OK." "Tell him his mother called." "Thanks." "I don't believe it." "He just had surgery and he's out with friends!" "Your son is insane." "Where does our son get that?" "From me, of course." "That means he can't be too bad." "Hand me some water, please." "Didn't Carroz d'Araches have any rooms?" "I called 3 hotels, everyone's full." "It's the seasonal ski instructor competition." "In Flaine, Pierre et Vacances only does weekly rentals." "I'm a little old to sleep at a youth hostel." "Jack's boss was nice enough to give us a room." "One room?" "Yes." "It's full there, too." "It's for kids, they probably have bunk beds." "What!" "We'll feel young again!" "Especially you." "Ridiculous!" "So, feeling restless?" "I came by and you were out." "I'm not used to sitting around." "Alright." "Let's see." "Does it hurt a lot?" "I'm taking painkillers." "It looks good." "Here are the X-rays." "It's all explained on the file." "Give this to your doctor in Belgium." "Okay." "Good news, you're getting out tomorrow." "Good luck, don't do anything crazy." "Don't walk on it for 4 weeks." "Your fracture needs time to heal." " Thanks, Doctor." " Have a good day." "You're lucky." "I need both arms in the kitchen." "I don't know where to go before I can work again." "And my family is in Algeria." " Where is the old man?" " The ICU." "He couldn't breathe." "Poor old man." "Here, man." "Good luck." " It'll be ok." " Yeah, like always." "I'm locked in!" "Hello?" "I'm locked in!" "Shit!" "No!" "I'm locked in the bathroom." "No one can hear." "Apparently neither can you." " Hello." " The men's room is there." "I know, but?" "I'm waiting for my wife." "Something's wrong." "All the same." "The same story." "That way, pervert!" " What?" " You heard me!" "Leave, now!" "You're going to look now, or I'll get a manager." "We wasted a half-hour and I was called a pervert." "I thought you'd fainted." "It's so typical of you!" "Don't yell at me, I didn't know the door was broken!" "Frans, slow down." "I think there's cops." "Huh?" "Where?" "Behind us, I saw a siren." "I can't see it." "When Jack was little, with his babysitter..." "Locked in the bathroom, he couldn't open the door." "Poor baby." "Where was it?" "Charente-Maritime." "He was 3." "You told me, but I wasn't there." "You were gone a lot." "Well no, no." "I was gone a lot." "You think he missed me?" "At first, yes, definitely." "Just after you left, he said:" ""Daddy's going to build a house, we'll live together."" "It was simple for him." "Later on?" "I don't know." "That music's cool." "What is it?" "No, but it's not bad." "Did you tell your parents?" "I don't have any battery." "I'll call from Flaine." "Room 205, please." "Follow the green line to the end." "Take elevator A to the 2nd floor." "Then the doors to the right to room 205." "What?" "Follow the green line." "OK?" "To the end." "You take the elevator." "Elevator A." "What's that?" "I didn't understand." "I'll take you to the elevator." " Ma'am." "Ma'am." " Sorry, I'll be back." "Not bad." "Recent construction, clean." "Surprising for France." "I hope the surgeon was good." "Hello." "We're here for Jack Vander." "What room number is he in?" "Mr. Vander left this afternoon." " What?" " He left at 4:00." " We'll send the bill to Belgium." " OK." "Thanks." "You're welcome." "What?" "Where is he?" "In Flaine." "Where else?" "It's ringing but no answer." "I'll try again." "Jack, how are you?" "Does it hurt?" "We were scared." " Thanks for the chocolate." " You're welcome." " Your foot is black and blue." " I call it Smurf." " Hey!" " Oh, hey." "And?" "You're back!" "How did you get out?" " Isn't it 5 days minimum?" " I was going crazy." " Hi, Jack." " Hi." "We're glad everything's OK." "Who was the surgeon?" "Dr... "think fables"." "Lafontaine." "He's the best." "Your parents are coming tonight." "They have a room." " Cool, thanks." " No problem." "You should lie down with your leg up, OK?" "Ask if you need anything." "Thanks, boss!" "OK." ""Your leg up", not something else up." "Shut up, Clement." " He could have called." " Maybe he has no battery." "He's not in the hinterlands though." "No." " I think he's in love." " Oh!" "How do you know that?" "He should have come home last week, but he said he wanted to ski." "I asked him if he met someone." "He said:" ""Yes, she's great, Mom."" "That Jack!" "Do you know who it is?" "No." "I just know her name's Alison." " Is she American?" " I don't know." "Why doesn't he ever tell me these things?" "You're both men." "It's weird." "Just concrete." "That's right." "A 1960 construction." "In harmony with the mountain." "It's a unique resort." "A great architect built it, Marcel Breuer." " Were you mad at me?" " Huh?" " Were you mad at me?" " Why?" "For leaving you." "No." "I was mad at myself." "For not trying." "It was a long time ago." "I like being alone now." "Shall we?" "Hi." "You're Jack's mom." "I can see right away." "We have the same expressions." "Do I look like his dad?" "Not as much." "Maybe the accent." "Alright." "Jack is in room 715, at the end." "You are just before his, room 700." "Call if you need anything." "I parked the car by the entrance." "Can I leave it?" "It's OK for an hour, then move it to the lot." "The cheaper one is Flaine forest." " Thank you, Ma'am." " Thanks!" "You know we love your son." "So do we." "Here it is." " Hi, come in." " Hi." "Hi, Mom." "Hi, Dad." "How was your trip?" "How are you, son?" "This is nice." "This is Al

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votação (15th alteração). Ele e seus colaboradores, como tantos liberais classe superior euros, então e agora, foi cego pelas ilusões sociais utópicas encarnado no cristianismo e na democracia, que resultam da 295 psicologia da aptidão inclusiva de intuições coalizões e altruísmo recíproco, que foi eugênico e adaptativo no EEE (ambiente de adaptação evolutiva-i. e., de ca. 50.000 a vários milhões de anos atrás), mas é fatalmente disgênico e maladaptável nos tempos modernos. Note a grande ironia da citação dele que começa o livro, que mostra que mesmo os mais brilhantes são vítimas de seus próprios limites, e não têm nenhuma compreensão da biologia humana, psicologia ou ecologia. Nunca passou pela sua cabeça que o mundo se tornaria horrivelmente superpovoado e que os africanos cresceriam para se tornar um problema social gigante, em casa e para si e para o mundo como a África se expande para mais de 3.000.000.000. Da mesma forma, apesar do desastre agora claro, parece não cruzar Obama que o diverso em casa e no exterior vai destruir a América eo mundo, embora qualquer brilhante de dez anos de idade pode vê-lo. O Presidente Truman poderia ter deixado McArthur usar a bomba atômica para acabar com a guerra coreana, destruir o comunismo e evitar o horror contínuo da China executado por 25 sociopatas (o Politburo) ou realmente apenas sete sociopatas (o Comitê ereto de Politburo) ou talvez realmente apenas um sociopata (Xi Jinping). Johnson poderia ter feito do mesmo modo no Vietnã, Bush no Iraque e Obama no Afeganistão, Síria e Líbia. China e provavelmente muitos países do 3o mundo teriam usado armas nucleares se as situações fossem invertidas. Uma vez que um país muçulmano radical recebe a bomba, um ataque preventivo por eles ou sobre eles provavelmente ocorrerá,, e isso é provável por 2100 e perto de certo por 2200. Se Gaddafi tivesse conseguido os seus esforços para conseguir a bomba, seria muito provável que tivesse acontecido. Os EUA poderiam ter forçado o Japão, a China e a Coréia, o Iraque e a Líbia e todos os países da Europa (e todo o mundo para esse assunto) a pagar pelos custos dos nossos esforços militares em todas as guerras recentes, e entre guerras, em vez de assumir a maior parte do custo e, em seguida, ajudá-los a assumir a maior parte da fabricação da América. É claro que essas decisões, críticas à sobrevivência do país, foram feitas por um punhado de políticos sem consultar os eleitores. Os Kennedy foram uma parte importante da mudança das leis de imigração em meados dos anos 60, então eles têm que contar como traidores e grandes inimigos da América em um par com Obama, G. W Bush os Clintons. Poderíamos ter seguido os fundamentos universais da indústria dos EUA e se recusou a assinar o GATT, que deu acesso livre a todas as nossas patentes anos antes de serem concedidos, embora, naturalmente, os chineses agora hackear e roubar tudo com impunidade de qualquer maneira. Eisenhower poderia ter deixado o Reino Unido manter a posse do canal de Suez, em vez de chantageá-los para sair do Egito, e sobre e sobre. Alguns podem estar interessados em algumas estatísticas para dar uma idéia de onde estamos atualmente na estrada para o inferno. Veja as tabelas no início. Nos EUA, a 296 população de hispânicos vai inchar de cerca de 55 milhões em 2016 (ou tanto quanto 80 milhões se você aceitar algumas estimativas de ilegalidades 25 milhões-é uma marca de quão longe o governo deixou as coisas vão que nós realmente não sabemos) para talvez 140 milhões meio século e 200 milhões como entramos no século 22 , momento em que a população e.u. vai estar subindo passado 500 milhões, e a população mundial será de cerca de 11 bilhão, 3.000.000.000 de que acrescentou a partir de agora para então na África e 1.000.000.000 em Ásia (as estimativas oficiais da ONU no momento). Os hispânicos estão se reproduzindo tão rápido que os euros, agora uma maioria 63%, será uma minoria por meio século e cerca de 40% por 2100. A maior parte do aumento nos EUA a partir de agora será hispânicos, com os negros restantes, asiáticos e muçulmanos, e todo o aumento aqui e no mundo será 100% diverso. Cerca de 500.000 pessoas são naturalizadas anualmente e uma vez que são principalmente do mundo 3 e produzem crianças em cerca de duas vezes a taxa de euros, que irá adicionar talvez 2 milhões meio século e 5 milhões por 2100 para cada ano que continua. Para mostrar o quão rápido as coisas saíram do controle após o "sem impacto demográfico" TKO (técnico nocaute ou Ted Kennedy indignação, embora pudéssemos igualmente chamá-lo de ultraje LBJ, o ultraje Neomarxista, o ultraje liberal etc.) ato de imigração de 1965, há agora mais hispânicos na Califórnia do que há pessoas em 46 outros Estados. Em 1970 logo após o TKO, havia cerca de 4 milhões hispânicos e agora há mais de 55 milhões "legais" (ou seja, não é feito legal pelos eleitores, mas por um punhado de políticos e da Suprema Corte estúpida) e talvez 80 milhões contando ilegais. Nunca atravessa as mentes do bloco democrático-voto pobre diverso que aqueles que sofrerão de longe mais da "diversificação" dos Estados Unidos são eles mesmos. Os E.U. passou de 84 por cento branco, 11 por cento preto, 4 por cento hispânicos e 1 por cento asiáticos em 1965, para 62 por cento branco, 11 por cento preto, 18 por cento hispânicos e 6 por cento asiáticos agora, de acordo com um relatório recente do Pew. Por 2055, nenhum grupo é esperado para ter uma maioriaum cenário perfeito para o caos, mas você pode ver inúmeros da Academia (agora um paraíso para o estado financiado Neomarxisto terceiro mundo supremacismo) elogiando o multipartisanismo. Os asiáticos estão previstos para aumentar mais rápido do que qualquer grupo, dobrando a sua percentagem nas próximas décadas, mas pelo menos eles vão ter ido através de um procedimento de imigração mínima, exceto, naturalmente, para as famílias de bebê âncora (produzindo que agora é uma grande indústria como Os asiáticos voam aqui para dar à luz, embora sejam grandemente ultrapassada pelos hispânicos que só têm de atravessar a fronteira à noite). Naturalmente, os asiáticos são por e grande uma bênção para a América como eles são mais produtivos e menos problemas do que qualquer grupo, incluindo euros. O governo dos E.U. (sozinho dos países principais) empurra a "diversidade" mas nos países pelo mundo inteiro e durante todo a história as tentativas de sold

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[@acc09].[]{data-label="Fig:IC443"}](IC443.eps "fig:") -0.0 true cm ![Same as Fig.\[Fig:M1\] but for middle-aged SNR W44. Upper panel: the blue dashed-dotted, purple dashed, and red solid lines correspond to $t=\rm 1 kry$, $\rm 5 kyr$, and $\rm 10 kry$, respectively, with $B=\rm 400 \mu G$. Lower panel: the dashed, dotted, and dashed-dotted lines correspond to $B=\rm 400 \mu G$, $\rm 200 \mu G$ and $\rm 100 \mu G$, respectively, at $t=\rm 10 kyr$, and the solid line represents the CBPL spectral fitting model. Also shown are observational data in radio by VLA (red points) [@cas07], and by Sardinia Radio Telescope (green triangles) [@lor18; @egr17], in $>0.1$ GeV gamma-rays by Fermi-LAT (cyan squares) [@ack13], and by AGILE (blue circulars) [@giu11].[]{data-label="Fig:W44"}](W44ED.eps "fig:") ![Same as Fig.\[Fig:M1\] but for middle-aged SNR W44. Upper panel: the blue dashed-dotted, purple dashed, and red solid lines correspond to $t=\rm 1 kry$, $\rm 5 kyr$, and $\rm 10 kry$, respectively, with $B=\rm 400 \mu G$. Lower panel: the dashed, dotted, and dashed-dotted lines correspond to $B=\rm 400 \mu G$, $\rm 200 \mu G$ and $\rm 100 \mu G$, respectively, at $t=\rm 10 kyr$, and the solid line represents the CBPL spectral fitting model. Also shown are observational data in radio by VLA (red points) [@cas07], and by Sardinia Radio Telescope (green triangles) [@lor18; @egr17], in $>0.1$ GeV gamma-rays by Fermi-LAT (cyan squares) [@ack13], and by AGILE (blue circulars) [@giu11].[]{data-label="Fig:W44"}](W44.eps "fig:") SNR IC 443 and W44 are two middle-aged ($\sim \rm 10kyr$) SNRs surrounded with dense molecular clouds (MCs) [@ack13; @car14; @tav10; @fan13; @uch10]. Since they are close (with distances of 1.5 kpc and 2.9 kpc for IC 443 and W44, respectively) and bright in gamma-ray energies, they are the best studied SNRs so far. @ack13 shows that the 4-year observations with Fermi-LAT on IC 443 and W44 reveal the characteristic “pion-decay bump" in the sub-GeV gamma-ray spectra, which tends to exclude a leptonic-only model for the GeV gamma-ray emission from IC 443 and W44. This provides an evidence of CR acceleration in SNRs. If the GeV emission is produced by hadronic interactions, there should be accompanying SEPs which produce synchrotron radiation in the postshock magnetic field. Again we use CBPL spectral model to fit the gamma-ray data of SNRs IC 443 and W44, and then the best fitting parameters are shown in Tab.\[Tab:spectral fitting\]. The results of derived SEPs’ and synchrotron radiation spectra are shown in Figs.\[Fig:IC443\] and \[Fig:W44\] for IC 443 and W44, respectively. We see that the synchrotron flux increases with the magnetic field. Since the predicted flux cannot exceed the observed radio emission, we can give upper limits to the magnetic field, $B\la350\mu$G and $\la400\mu$G for IC 443 and W44, respectively. However, the predicted flux and spectral index are both well consistent with observations, which may implies that the radio emission is mainly produced by the synchrotron radiation of the SEPs. In fact, the observed radio spectral index, if explained by synchrotron radiation, needs a power-law distributed electron population with a spectral index $p=1.75$, which is harder than DSA predicted index $p\approx2$. These facts suggest that the radio emission from IC 443 and W44 is more naturally explained by SEP radiation with magnetic fields $B\simeq350\mu$G and $\simeq400\mu$G, respectively. Discussion ========== In the hadronic model for RX J1713.7-3946, a spectral bump in $10^{-5}-10^{-2}$eV may show up if the magnetic field is the order of mG (Fig.\[Fig:M1\]). Observations in microwave to far-infrared bands are encouraged to confirm if it is there, and test the origin of the gamma-rays. However, an upper limit $B\la2$ mG is constrained in this model by the observed radio flux. @hua08 have obtained comparable result of the magnetic field by carrying out a detailed Monte Carlo particle collision calculation of the SEP production. We here directly use the observed gamma-ray spectrum to derive SEP spectrum analytically, avoiding the complicated numerical calculation of the hadronic interactions. The synchrotron spectrum from radio to X-ray bands from SNRs can be used to constrain the magnetic field $B$ in the SNR shocks, as discussed in [@wangli14]. In the spectrum there is a spectral break $\nu_{\rm cool}$ corresponding to the electrons with a radiative cooling time equal to the SNR age, $h\nu_{\rm cool}\approx3(B/100\unit{\mu G})^{-3}(t/1\unit{kyr})^{-2}$eV, only function of $B$ and $t$ [e.g., @kw08]. If the injected electrons’ index is $p$, then the synchrotron spectral slope changes from $F_\nu\propto\nu^{-(p-1)/2}$ below $\nu_{\rm cool}$ to $F_\nu\propto\nu^{-p/2}$ above $\nu_{\rm cool}$. Given the observed radio flux (below $\nu_{\rm cool}$), and the X-ray flux (maybe above $\nu_{\rm cool}$, we can constrain $\nu_{\rm cool}$ and then $B$. For $p\sim1.8$ [@hes16] derives $B\sim70\mu$G in RX J1713.7-3946. If $p\ga2$ as expected by DSA theory, $\nu_{\rm cool}$ is larger and $B$ becomes smaller, $\sim10$’s $\mu$G. Small $B$ will lead to enhancement of the inverse-Compton (IC) radiation, and favor leptonic model for the gamma-rays from RX J1713.7-3946. If the bulk of gamma-rays from RX J1713.7-3946 is mainly produced by leptonic process, the possible hadronic component should be below the observed flux. A promising flux of pionic gamma-rays is assumed in Fig.\[Fig:M2\]. The corresponding SEP radiation may show up at $\ga100$keV. For synchrotron radiation at 100 keV, the corresponding pionic gamma-ray energy should be $\sim1$ PeV provided the magnetic field strength $B \sim \rm 10 \mu G$ [@wan16]. So a detection of hard X-rays at $100$ keV may provide the evidence of existence of PeV gamma-rays and hence CRs beyond the spectral knee from the SNR. However, a deep observation in the level of $\sim10^{-13}\rm erg\,cm^{-2}s^{-1}$ is required for the future hard X-ray telescopes. As for IC 443 and W44, the derived SEP radiation can well match the radio data with $B=350\mu$G and $400\mu$G, respectively (Figs \[Fig:IC443\] and \[Fig:W44\]). Besides the “pion-decay bump", these results further support the hadronic origin of gamma-rays. The required relatively large magnetic field, $B\sim100$’s $\mu$G, is consistent with the hadronic model but disfavors leptonic one [e.g., @car14]. Moreover, the large $B$ can be well explained by the large density of the surrounding MCs, since the postshock magnetic field is $B\sim\sqrt{8\pi\epsilon_Bnm_pu_s^2}$ (with $\epsilon_B$ being the energy fraction of the postshock internal energy carried by magnetic field). For example, for W44 the CO data obtained from the NANTEN2 telescope imply a dense medium with $n \sim 250 -300 \rm cm^{-3}$ [@car14], then the postshock magnetic field is $B\sim0.4(\epsilon_B/10^{-1})^{1/2}(n/200\unit{cm^{-3}})^{1/2}(u_s/300\unit{km\,s^{-1}})$mG, consistent with the requirement for SEP radiation to account for the radio emission. The measurement of the postshock magnetic field is important for the study of the collisionless shock physics. In any case, by requiring the SEP synchrotron radiation not exceeding the observed radio-to-X-ray flux we can give an upper limit of the magnetic field. This is simply true if the gamma-rays are hadronic origin. If, however, the gamma-rays are leptonic origin, an even low magnetic field is required to model the radio to gamma-

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's photograph in this casual way." "Then it won't perhaps be tactful to give Lady Cantelupe a receipt for it." And Appleby picked up the photograph of Marian Page. "But you can be a witness that I'm making off with it. And now I must go and make some inquiries elsewhere." Diamond seemed surprised that their interview was over. "Well," he said – and his voice was ever so slightly jaunty – "I hope you've learned something here for a start." "As a matter of fact I have. Quite a lot. Good morning." Late that evening, as the two men dined together, the Minister listened moodily to Appleby's account of his investigations during the day. "And the girl – this Marian Page?" he asked. "She has certainly disappeared. The lab got a telephone message on the Monday, saying that she was unwell and would be away some days. And her landlady got a similar message that afternoon, saying that Miss Page had heard that her mother was dangerously ill, and had gone at once to join her in the country. I've checked that the message was false. Miss Page's mother is quite well." "People seem to have been a bit casual about the girl. Do you think it sounds like her running away with Cantelupe? I don't." Appleby shook his head. "I don't believe it for a moment. And I don't believe that he shoved her, or any girl, into a cupboard. It's not the way that a man like Cantelupe makes an ass of himself. And what is suggested to me by the manner in which he left his house is something quite different." "Different?" The Minister waited for a moment. And when Appleby said nothing he added: "But there was that photograph." "There was indeed. It told me quite a lot. For one thing, I recognised it. I'd seen the girl – and with Cantelupe." "Good lord!" "It was about a month ago. I didn't recognise Cantelupe at the time, but I've checked up on my memory since. It was in a rather smart restaurant to which I'd taken my wife. Cantelupe was giving the girl dinner." "I see. And what was she like?" Appleby drained his tankard. "She was all right." "You mean–?" "It was a clear case, on its own high level, of the boss having infatuated himself with a girl about the place. She was handling it as well as she could. I expect she liked her job rather more than she liked him. A capable girl of strong character, I'd say." The Minister considered. "That would explain the photograph, and its decidedly temperate inscription." "Ah – the inscription. That introduces something else. In fact, the villain." "The villain, my dear Appleby?" "Just that. In tragic life, God wot, no villain need be. But this isn't tragic life, Minister – or if it is, it's criminal investigation as well. That photograph, you know, was leaning against a mirror. When I took it up, I saw the reflection of the back. It was blank. But Diamond realised he had made a slip in claiming to be able to identify the thing, and when I was examining the cupboard, he supplied that neat pencilled script himself." "Well, well!" The Minister had to make some effort to take this in his stride. "Would you say, then, that there was some intrigue between Diamond and the girl?" Appleby shook his head impatiently. "No. Consider the sequence of events. Cantelupe, who is impressionable in ways that his wife has learned to discount, starts up this middle-aged man's passion for Miss Page. He turns worried and nervous – which is a normal reaction to such a situation. On Monday Miss Page vanishes, to the accompaniment of those bogus telephone messages. On Tuesday morning Cantelupe goes out and makes a mysterious purchase. That afternoon there is the even more mysterious incident reported by Butt. Cantelupe's worry then turns to desperation, and on Thursday he disappears too. And you remember how he disappears?" The Minister nodded. "He walks out of his house, and straight past his own waiting car and chauffeur." "Precisely. It's not how a man in Cantelupe's position goes off for a lark – or even upon some serious resolution to make a complete break with his whole past life. It bears quite another character – and one, I suppose, that is sufficiently obvious." "Nervous breakdown?" "Just that. Or what they call, technically, hysterical fugue. Complete loss of memory, and disappearance into the blue." The Minister considered for a moment. "When a chap goes right round the bend in that way, isn't he pretty quickly picked up?" "Not always. Sometimes he behaves with a sort of unconscious cunning that defeats even an active hunt for days or weeks. Thanks to Lady Cantelupe's delay – and the obscure and sinister role of Diamond – there's been no hunt for Cantelupe until today." "Oughtn't this Diamond fellow to be locked up – or at least be made to give some account of himself?" The Minister had a recurrence of his mildly sardonic manner. "It's generally regarded as the right line with villains." But Appleby shook his head. "If I'm right in the way I see this case," he said gravely, "then the last thing we want do is to alarm Charles Diamond." Every newspaper next morning carried the story of Lord Cantelupe's disappearance. He was described as having been missing for several days. Scotland Yard believed that he was suffering from loss of memory. Importance was attached to reports that a man answering to his description had been seen in Cambridge, behaving in a dazed manner that had attracted attention. Lord Cantelupe was a Cambridge graduate, and it was thought that he might have returned to familiar ground. The police were conducting an intensive search both in the city and the surrounding countryside. It was in tones of considerable impatience that the Minister spoke to Appleby on the telephone shortly after breakfast. For one thing, there had been some delay in getting him through. "Look here, Appleby, did that news have to break like that? And how did the papers get on to it?" "I put it out myself. You don't disapprove?" Over the wire, Appleby's voice sounded flat and tired. "My dear fellow, you're a pretty sound judge. And it's good that we've got that line on Cambridge. But need that have gone out? There may be less virtuously disposed people than ourselves after him, remember." "There certainly may. But I don't think there's any extra danger in what we've done." Appleby's voice paused. "I think, Minister, you'd better come round and see me." "I come round and see you?" The Minister was startled. "At New Scotland Yard?" "No, no. I'm in Cantelupe's library. They got you through to me here. I think you'll be – well, interested." "I'll take your word for that. Give me ten minutes." And the Minister slapped down the receiver. There were two uniformed inspectors in the book-lined room. The Minister gave them a nod and then turned at once to Appleby. "Well, here I am. What about that fellow Diamond? I'm still uneasy at his being loose. Where is he?" "Not in this house – where I think he's ceased taking his duties very seriously. I rather hope that he's in Cambridge by this time." The Minister stared. "You mean that's all rot?" "Certainly. No more than an attempt at a little diversionary action. We still haven't a notion about Cantelupe's whereabouts. All we've got is his overcoat." "And how on earth–" "On Thursday evening he dined by himself in the very restaurant in which my wife and I saw him entertaining Miss Page. The head waiter thought he looked queer. And when he left he forgot his coat. And in the pocket there was that." Appleby picked up from a table beside him a small cigar-box. "Inside which there was this." He opened the box. It contained a broad, flat spool of metal ribbon. "The sequence is clear. Cantelupe received this by post on Tuesday morning. He didn't, here at home, have the machine to play it back on–" "You mean it's for one of those tape-recorder affairs?" "Of course it is, Minister. And Cantelupe went out, then and there, and bought one. It was, in fact, the large parcel he was seen bringing into this room. It's standing just behind you." The Minister swung round. "And the fellow you were telling me about, who sounds as if he was out of Happy Families–" "Mr Butt the butler? Precisely. But what he heard through the door was not the voice of an actual woman, but the voice of a woman recorded on this." Appleby tapped the cigar-box once more and then handed it to one of his colleagues. "I think, Minister, you'll find what it has to say rather striking." There was silence for a few moments while

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invention is useful with all types of memory chips, including DRAM, SRAM (Static Random Access Memory), EEPROM (Electrically Erased Programmable Read Only Memory), and FLASH, a fast EEPROM. A high priority is the progression of DRAM memories, which are currently being redesigned to go from monolithic 16 MEG units to 64 MEG units. In the current redesign of SRAM memory units, the effort is to go from 1 MEG to 4 MEG units. The field of logic devices, e.g., FPGAs, is presently limited by the need for greater density of available gates and transistors, in order to perform more complex tasks.According to my numbering system, I'm up to 125 finished strips, 100 of which have actually been posted. I have about 15 or so that are outside of that I did before that numbering system (some posted, some not), and probably another 30 strips that are written an waiting to be finished up. I have a tablet PC that these have all been drawn on, which makes it go way faster than ink on paper. The downside is I have no hard copies to sell. The upside is that I actually have the time to do the darn thing. I draw them in batches of 10, sketching them all, then inking them all, then shading them all. This assembly line method seems to be working out well. Not sure what the Southland comment is about. I'm still in the Seattle area and loving it. This cartoon is not that much of an exaggeration from reality! My stepdaughter is a nurse, and A LOT of her bedridden patients were this big. When it was necessary to turn the patients over into a different position, she had to summon a special hospital "lift team" to do the job. Remember that great cartoon "Triplets of Belleville" where the city was full of enormously fat people?The Antikythera Mechanism is a primitive ancient computer of sorts, that using gears only, could predict astronomical positions. It was found in 1900 AC in a shipwreck, near the greek island of Antikythera. It is dated back to 150-100 BC. When a date was entered via a crank (now lost), the mechanism calculated the position of the Sun, Moon, or other astronomical information such as the location of other planets. Since the purpose was to position astronomical bodies with respect to the celestial sphere, with reference to the observer's position on the surface of the Earth, the device was based on the geocentric model. Speaking of free time, Facebook staff has free time. There work space have legos,there staff is encouraged to doddle around with all the games and continue thinking all the time. They skate board and use bikes and all kinds transportation. They keep them busy so they will forget about leaving,they feed them at work. The Bomb sights in WW II that used gears for calculation of airspeed, groundspeed, windspeed, and bomb profile were called analog computers, so I suppose that would apply to any mechanical solution. Digital is the realm where any signal or measurement was converted to binary for processing through gates/memory. Analog with electricity example would be op amps which simulate springs, dashpots, and levers in real life. Well, is a divide by 3 circuit using flip-flops analog or digital? Why isn't a divide by 3.xx using gears and an escapement the same? It is the flip-flop that actually got me wondering about modern classifications vs. marketing glitz. For example, Wikipedia describes the first "digital" watch in about 1920's and the Pulsar watches as being digital. The first was done with gears and simply had a digital readout (an escapement mechanism can avoid the matter of in-between states). The Pulsar could be done with gears too. Quartz watches are admittedly much more accurate that spring-loaded clocks, for example and it is nescessary to build a digital circuit to harness the crystall's accuracy. Another matter is that digital circuits consume much less energy and suffer less from degradation and wear. On the downside, it can be very tricky to solve a problem with a digital construct. Think of how many multiplication algorithms exist for the binary algebra. On the analog realm of two gears, you have a set gear ratio and by turning the first gear x times, the other is turned automatically by {x times the ratio}. But at what cost, with what accuracy, in what time and untill when? One question though.... Does Lego actually have those parts as play toys. And I like to know what kinda software is used in the animation. Are they pretty powerful or expensive.. What can I use in my level of work. I like to draw my Engraver Machine before I buy the parts. What kinda software are used to animate/draw those kinda objects. Well, is a divide by 3 circuit using flip-flops analog or digital? Why isn't a divide by 3.xx using gears and an escapement the same? It is the flip-flop that actually got me wondering about modern classifications vs. marketing glitz. For example, Wikipedia describes the first "digital" watch in about 1920's and the Pulsar watches as being digital. The first was done with gears and simply had a digital readout (an escapement mechanism can avoid the matter of in-between states). The Pulsar could be done with gears too. John Click to expand... A "Digital" Display is different than operating in the digital realm. There are clocks that move pieces of wood around to shape numbers, much like a 7 segment display. Making digits through this method could possibly not involve digital electonics at all (though the example I am thinking of does use a uC). Digital systems are essentially systems that use electronic level based (typically binary, but multi-valued logic exists) arithmetic to provide output. Analog systems do not assign values to levels, the measured voltage or current has no discrete steps as digital does. One question though.... Does Lego actually have those parts as play toys. And I like to know what kinda software is used in the animation. Are they pretty powerful or expensive.. What can I use in my level of work. I like to draw my Engraver Machine before I buy the parts. What kinda software are used to animate/draw those kinda objects. Click to expand... Yes, all these parts, even the differential, are official LEGO parts. The olny exception are the printed paper gauges LEGOs are expensive toys, as a general rule, but they never break. You buy them for life. Except if you leave them to rot for 3 years in the mercy of the elements like a friend of mine did. Then yes, the plastic will become brittle and fail. There are a couple of LEGO design softwares. Some are free and supported by LEGO. It makes sense, since they tease you with all those extensive libraries and then you decide to actually buy the parts. However they support only LEGO parts and will be of little use for any other purposes. Last time I checked was 2 years ago, with a software named LEGO Digital Designer. It had some issues though with too many block conflicts in the 3D space.Libertarian White House hopeful Gary Johnson said Tuesday it’s been his stated position that legalizing marijuana will lead to less substance abuse overall. “I took the position I took business-wise to make the world a better place,” Mr. Johnson, the former New Mexico governor, said on CNN’s “New Day.” “On the medicinal side, marijuana products directly compete with legal prescription drugs that statistically kill 100,000 people a year,” he said. “And on the recreational side, I have always maintained that legalizing marijuana will lead to less overall substance abuse.” Mr. Johnson, who won about 1 percent of the popular vote as the Libertarian Party’s presidential nominee in 2012, said there is a “total disconnect between elected politicians and the public.” “Sixty percent of Americans now want to legalize marijuana,” he said. “But the campaign to legalize marijuana in Colorado was a campaign based on marijuana is safer than alcohol, and it is. It’s safer than everything else that’s out there, starting with alcohol.” The Libertarian Party will choose its presidential nominee later this month at a convention in Orlando. Sign up for Daily Newsletters Manage Newsletters Copyright © 2020 The Washington Times, LLC. Click here for reprint permission.Bourne developers will build hotel first In an overture to wary Bourne sewer commissioners, the team behind a proposed Buzzards Bay development has offered to build a "brand name" hotel before tackling a $55 million, seven-story mixed-use complex. Comment By C. Ryan Barber capecodtimes.com By C. Ryan Barber Posted Jul. 10, 2014 at 2:00 AM By C. Ryan Barber Posted Jul. 10, 2014 at 2:00 AM » Social News BUZZARDS BAY — In an overture to wary Bourne sewer commissioners, the team behind a proposed Buzzards Bay development has offered to build a "brand name" hotel before tackling a $55 million, seven-story mixed-use complex. Perry Ave. Corp. developers have offered to flip-flop the project's first two phases in hopes of accommodating the sewer commissioners who have raised concerns about

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Series events at TMS in 2009 and 2010, is working on a stretch of six consecutive top-five results at “The Great American Speedway!” “I look forward to Texas anytime,” said Bodine, 47, who posted his first Truck Series win at TMS in October 2004. “Even outside the trucks – in Nationwide and Cup cars – I’ve run really well here. Anytime you have success at a track you enjoy the whole experience. Makes it nice to go back when you’ve got a shot to win.” That was one of Bodine’s selling points to Brendan, who spent the last two seasons in Brendan Gaughan has found a nice, fast home at Germain Racing. (RacinToday/HHP photo by Erik J. Perel) the Nationwide Series at Rusty Wallace Racing with funding largely provided by the Gaughan family’s South Point Hotel & Casino in Las Vegas. That sponsorship is funding the debut of the No. 62 Big Red Tundra this weekend. “I’ve been trying to get Brendan and Mr. Gaughan to race for us for three or four years,” said Bodine, who has finished among the top-five in points in five consecutive NCWTS seasons. “He finally got tired of running 15th and 20th in Nationwide and decided he ought to take a look at it here. “Me and Brendan have been longtime friends anyway. He stood up as a groomsman at my wedding (to Janet Paczkowski) last year. Everybody likes Brendan. Can’t help but like Brendan. He’s a good driver and good people and that fits our program.” Bodine believes his attitude toward the tour’s intermediate tracks has factored into his success at TMS. “I enjoy ‘em. And even with the ‘cookie-cutter’ thing…they all still have their own characteristics,” said Bodine, who trails only Kyle Busch’s seven all-time wins (five Truck/two Nationwide) at TMS. “They‘re not all the same and that’s what I find challenging _ figuring out those challenges and how to make them work to my benefit. Our 1.5-mile program, it’s our strong suit. We’ve won there (TMS) enough that I understand what you need to do; it’s a matter of getting the truck to do it for me.” Beyond Goodyear Racing’s ever-evolving tires, Bodine credited Hillman Jr.’s remarkably consistent setups with being a difference-maker. “We’ve only changed small things in our setup,” said Bodine, who has logged 21 Truck Series wins with Germain Racing and 36 during his NASCAR career. “When you’ve got a book that strong, it’s a great reason to be a part of that team, for sure. And that’s one reason Brendan and Mr. Gaughan wanted to come here. We’re going to run up-front.” Bodine has endured his worst start since joining the Truck Series fulltime in 2005, but a third-place finish in the O’Reilly Auto Parts 250 at Kansas Speedway last Saturday suggests better times are ahead at TMS. Bodine’s six wins in Fort Worth include four of the past five June races. Bodine is ninth in points, 78 behind leader Johnny Sauter. Additionally, Germain Racing has won 13 races on intermediate, or 1.5-mile, layouts like Kansas Speedway and TMS. Bodine also is the co-leader – with Kyle Busch – in intermediate track wins with 12. “It’s about luck,” said Bodine, recapping his uneven 2011 season. “Our performance has been good, just no luck at all. You can’t have a knee-jerk reaction if you’ve finished 14th Todd Bodine has a teammate with his kind of racing blood. (RacinToday/HHP photo by Erik J. Perel) or worse in most of the races. There’s nothing we can really change. We just need some luck. Last week was a great start. Hopefully we can keep it going.” Like the Bodines, the Gaughans boast a long and proud racing history. “My dad – he’s 68 – raced for 30 years in the off-road stuff,” said Gaughan, who followed his father into the desert ranks. “We love racing and love that genre and it’s meant a great deal for our business. It’s in the blood, it’s in the business model and it fits into our customer base. Whether I was driving or not we still have racing built into the budget. We’ll always have something racing with the South Point banner on it.” Gaughan followed-up his four consecutive wins at TMS with a near-championship in 2003, when he went into the NCWTS season-finale at the 1.5-mile Homestead-Miami Speedway with the point lead. Unfortunately, a mid-race accident relegated him to fourth in the final standings. Gaughan graduated to a Sprint Cup Series ride in 2004 in the No. 77 Dodge fielded by Doug Bawell in partnership with Roger Penske. After finishing 28th in points as a Cup rookie with only one-top five, Gaughan returned to the Truck Series in ‘05. Recapturing that “magic” has become Job One. “Anybody that knows me knows this is what I want to do for a living,” said Gaughan, currently 10th in points and 87 behind leader Sauter after a seventh-place finish at Kansas Speedway. “I’ve got a great college education (Georgetown University) and own other businesses. This is what I want to do. My desire is here. That’s why I’m still working my tail off to do it. I’m not going to hang out and run in the back and say, ‘Hey, I’m here’ and use excuses. I want the best equipment to show that I can still win. And the Germans have got one of the top three (organizations) in the Truck Series. “We’ve had great trucks all year. It just seems that bad things happen to me when I’m up front. I got a truck in the top-five, I’ve got to watch for the sky falling on me. We’re hoping to get two top-10s in a row here; I’d be really happy.” To that end, Gaughan is working under a one-year contract with the organization headed by Bob Germain Jr. “It’s a handshake deal with the Hillmans, more of a hug with Hillman Sr.,” said Gaughan, a 36-year-old native of Los Angeles who began the season with eight career NCWTS wins. “It’s a real people relationship and it’s completely an open book. Hillman Jr. is the book I wanted. (Crew chief) Brian Berry, I’m happy with that. But we’re here to take whatever Hillman Jr. puts on Todd Bodine’s truck and run it.” Fittingly, Gaughan held the record for TMS victories until Bodine won his fifth race in 2009. Head-to-head in eight races beginning in 2005, Bodine has come out on top six times. “Texas is a race I’ve been looking forward to with this Germain Racing team,” Gaughan said. “Todd and I are good friends. The Texas thing with all the wins is a decent rivalry. I keep bragging I got four in a row. But I would love to have this come down to me and Todd, and have a shootout between us.”A Connecticut jury today heard a chilling 911 tape from a Bank of America employee who called police in 2007 when Jennifer Hawke-Petit, walked into the branch asking for $15,000 from her account so she could give it to the men who were holding her husband and children hostage. Haunting surveillance video was also shown of Jennifer Hawke-Petit leaving the bank and getting into a car with the man who, within hours, would rape and kill her. It was a grim start to the murder trial of Joshua Komisarjevsky, 31, who is charged with invading the Petit's home along with Steven Hayes. During the seven hour ordeal, the family was battered, sexually assaulted, and the wife and two daughters killed. The ony survivor of the July 23, 2007 attack was Dr. William Petit, who sat in the first row today. The voice of bank manager Mary Lyons filled the courtroom as the 911 tape was played. "We have a lady in our bank right now who says her husband and children are being held at their house," Lyons tells police. She testified that Hawke-Petit only had pictures of her daughters in her wallet instead of the required two forms of ID, but the bank teller gave her the money. She described Hawke-Petit as calm, despite the harrowing circumstances. The Second Petit Murder Trial Begins Grimly At one point she can seen leaning over the counter and whispering in an attempt to save her family. "To me, she was trying to get done what she was sent into the bank to get done, so she could return to her family," Lyons said. The bank manager said she watched as Hawke-

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)*-5*-2)/((sqrt(176)*-2 + sqrt(176))*6 + sqrt(176)). 3*sqrt(19)/2 Simplify ((3*sqrt(143)*-2 - sqrt(143))/(sqrt(11) - 1*sqrt(77)/sqrt(7) - sqrt(11) - sqrt(11)))**2 + (5 + (sqrt(65)*-2)/sqrt(5) - 2*2*sqrt(832)). -34*sqrt(13) + 657/4 Simplify (-5*3*(sqrt(540)/sqrt(5) + 4 + -5))**2*2. -5400*sqrt(3) + 49050 Simplify (-1 + -5 + -3*(sqrt(425) + -1) + 2 + sqrt(51)/sqrt(3) + -1*sqrt(272))**2. 36*sqrt(17) + 5509 Simplify 6*(sqrt(10)/(-1*sqrt(5)) + 5) + 5 + sqrt(450) + 1 + 3. 9*sqrt(2) + 39 Simplify 5*(2 + (2 + sqrt(80) + (sqrt(5) - sqrt(35)/(sqrt(28)/sqrt(4) + sqrt(7))) - ((sqrt(50)*1)/sqrt(10) + -5))). 35*sqrt(5)/2 + 45 Simplify 1 + sqrt(3) + ((sqrt(3) + 2)*-2)**2 + sqrt(12)/(sqrt(4)*-1) + 1 + -1 + 4 + -1. 16*sqrt(3) + 32 Simplify (-5 + -5*(((sqrt(108) + (sqrt(108) - (-5 + sqrt(108))))*-4)**2 + 4 + sqrt(108) + -3*sqrt(108)))*-6*-2. -127980 - 56880*sqrt(3) Simplify (-1 + 5*(-4 + -1 + (sqrt(363) - (sqrt(363) + 0))*-3)*-3)**2. 5476 Simplify (((-2*sqrt(198))/sqrt(9) + 2*sqrt(22)*-2)/(1*sqrt(44) + (sqrt(77) + -1*sqrt(77))/sqrt(7)))**2. 18 Simplify (-1*-2*-6*(-2*sqrt(190) - sqrt(190))*-6)/(((sqrt(90) - (sqrt(90) + -2*(1*sqrt(90) + sqrt(90)))) + (-1*sqrt(90) + sqrt(90))*-5)*-1). 18*sqrt(19) Simplify -5*((sqrt(171)*-2*-2 - (-1 + -1*sqrt(171) + sqrt(171)))**2 + (((-3*sqrt(1900) - sqrt(1900)) + sqrt(1900))*5*-2)**2). -8563685 - 120*sqrt(19) Simplify ((-3 + sqrt(1152) + (2*sqrt(1152) + 3 - sqrt(1152)) + 4)*-1 + -4)**2*-4. -18688 - 3072*sqrt(2) Simplify ((-4*(sqrt(12) + sqrt(12)*2) + sqrt(12))*6*-1)/((sqrt(396) - (sqrt(396)*-2 + sqrt(396)) - sqrt(44))/(-3*(sqrt(22)/sqrt(2) + sqrt(11)))). -396*sqrt(3)/5 Simplify ((sqrt(425) + 0)**2 + (sqrt(85)*-3)/sqrt(5) + -4 + 5)*5. -15*sqrt(17) + 2130 Simplify 3*(((sqrt(416)/sqrt(8))/sqrt(2))/(sqrt(2) - -1*sqrt(2)*-2)*-4 + -3). -9 + 12*sqrt(13) Simplify -6*((4 + -1*sqThe scene near Askeaton on the Rathkeale road where the bodies of Julia Holmes and Tom Ruttle were located at 3am on Monday Burglars discovered the badly decomposed bodies of an on-the-run fraudster and her partner when they broke into a rural farmhouse. The thieves rang gardaí in a panic after finding the remains of Julia Holmes (63) and Thomas Ruttle (56) side-by-side on a bed. The grandmother had the notorious distinction of being investigated by police on both sides of the Atlantic. Two handwritten notes, dated March 14, were found on the kitchen table of the house near Askeaton, Co Limerick, the Irish Independent can reveal. They were apparently signed by both of the deceased. A gang of well-known criminals stumbled on the bodies while they were ransacking the property looking for valuables. They fled the scene but feared they would be blamed for a double murder and rang gardaí at around 3am yesterday. Post-mortem examinations last night were inconclusive, but gardaí believe this was either a murder-suicide or a suicide pact between the couple. The house where the gruesome discovery was made was the home of Mr Ruttle, who was a separated father of grown children. He was a part-time farmer and mechanic from the area. He was the registered owner of two weapons, a rifle and a double-barrelled shotgun. It is understood a rifle was found on the floor next to the bed. Ms Holmes, who is originally from Ballynahinch, Co Down, had more than 20 convictions and was being sought by the gardaí and the PSNI for fraud offences. In 2006 she was deported from the US after she was arrested in connection with a $500,000 (€440,000) property scam in Texas. Irish IndependentCoffee at the office Quality Flexibility For your house or office, we adapt our services to your various environments. Speed To answer your needs, your order will be delivered directly to you within 48 hours. Coffee and Jeff de Bruges Chocolate Café Liégeois and Jeff de Bruges are partnering for your daily little moments For every Nespresso® compatible capsule bought, get a small chocolate Offer available with a minimum purchase of 30 capsules They trust us Coffee Beans A coffee directly from Europe that is assured to be fresh and meet your highest desires. Café Liégeois Newsletter Receive a 15% discount on your next order and stay up to date with the coffee world and Café Liégeois events."This batch has only been curing three days." "You want to explain that to the boss?" "'Cause I'll lend you the phone." "I'm just saying, it'll be a pretty harsh smoke." "Courier's coming for his two bags full, and that's what he's going away with." "Yes, sir, yes, sir." "Two bags full." "All set." "Did you see that bike?" "I bet that dude gets laid a lot." "I got to get me a bike like that." "Because that's the difference between you and him." "It's the bike." "What was that?" "I don't know." "Where'd my cheese puffs go?" "Where's your piece?" "I left it in the can." "Here." "I used to be a bouncer." "Cover me." "Hey, little guy..." "Hello." "And we thought there was something badass in here." "Primeval New World Angry Birds Original Air Date November 19, 2012" "Look, all I'm saying is, that before you go through another anomaly, at least give me the chance to collect some more data." "I didn't exactly plan it last time, Toby." "It just kind of happened that way." "Yeah, but if that's going to keep happening, then..." "I need to get an up-close look at one of these babies, you know?" "I need to get detailed readings, and start figuring out what really makes these things tick." "I thought your specialty was much more theoretical." "Well, there's something to be said about empirical evidence." "All right, we'll see." "Okay, fine, yes, yes," "I just want to see an anomaly, live and in person." "Well, admitting it is the first step." "Wow, you're sure settling in." "And I brought presents." "Wildlife tasers." "I thought we should have something in our arsenal besides Mac's cannons." "What are these going to do against giant lizards?" "It was designed to drop a charging rhino." "Oh..." "Point taken." "Mm-hmm..." "What do we have?" "Crap." "That's the new west warehouse district, next to the old pier." "There's lots of traffic there." "Okay, check the scanners for any emergency calls, any sightings in the area." "We'll call you from the road." "And..?" "Meet us out there with Mac when he shows up." "Bring those zappers." "You got it." "Yes!" "Uh-oh, where are you going?" "We have a follow-up with Umigen this morning." "I need to push that back." "Please tell me it's not another dinosaur." "We don't know what it is yet." "Dylan, hey, you've filled in the app for employee

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IUCN Water and Nature Initiative (WANI) is doing with IUCN Member, the University of the South Pacific, on Kadavu Island in Fiji. The Kadavu project works with local communities to help identify water catchment management challenges, and ways to overcome these which will result in better quantity and quality for water, both in streams and the coastal areas. The meeting took place in Koror, Palau, from 19-23 July 2010. The Pacific Islands Geoscience Commission (SOPAC) is the GEF Executing Agency for the Pacific IWRM Programme which is funded by both the GEF and the EU Water Facility IWRM Planning Programme.Campaigners who want better access at a train station has been recognised at a national awards ceremony for its hard work. The Chinley and Buxworth Transport Group scooped the Best New Group in the Railfuture organisation awards earlier in the month and also took home a commendation in the category Best Campaign. Paul Tattam from the group said: “These awards look at stations up and down the county and the fact we have won in one and been commended in another category is just fantastic and really reflects the hard work of everyone involved.” Railfuture’s annual Awards for Rail User Groups, which started in 2012, aim to recognise and reward local volunteers who come together and work tirelessly to improve their local railway - its stations and services - on behalf of their passengers, efforts which all-too-often would otherwise pass unheralded. Chinley and Buxworth Transport Group has been tackling the issue of access at the station as both platforms can only be reached by using two sets of steps. Paul said: “We want to make the train accessible for all, bet that parents with pushchairs, the disabled and those with bicycles and currently it isn’t. “bieng at the awards has raised our profile and is very good as it maintains interest in what we are doing and why. “I didn’t think we would win outright for our campaign and we lost out to a much bigger station in London but I really pleased with the special recognition.” Awards organiser Roger Blake said: “This new group has achieved a great deal in a short time. They still have a big challenge ahead of them, as small stations such as Chinley are fairly low down the pecking order when it comes to funding priorities, but it’s another example of where access improvements can reap huge benefits for existing passengers, and attract new rail users, this is why we supported the group.”Cardiac vagal tone: a physiological index of stress. Cardiac vagal tone is proposed as a novel index of stress and stress vulnerability in mammals. A model is described that emphasizes the role of the parasympathetic nervous system and particularly the vagus nerve in defining stress. The model details the importance of a branch of the vagus originating in the nucleus ambiguus. In mammals the nucleus ambiguus not only coordinates sucking, swallowing, and breathing, but it also regulates heart rate and vocalizations in response to stressors. In mammals it is possible, by quantifying the amplitude of respiratory sinus arrhythmia, to assess the tonic and phasic regulation of the vagal pathways originating in the nucleus ambiguus. Measurement of this component of vagal tone is proposed as a method to assess, on an individual basis, both stress and the vulnerability to stress.Niam Audio launches NaimUniti Things you might also like Naim Audio has announced the launch of the new "NaimUniti" an all-in-one audio player with an integrated amplifier, CD player, DAB/FM tuner, internet radio player, iPod and MP3 dock, digital to analogue converter, USB and network-stored music file player and network streamer. Offering a 10-input, 50-watt-per-channel integrated amplifier, users can hook up digital sources including games consoles, satellite TV recorders/receivers and DVD players to the audio player. Said to be easy to use, the system's front panel display is said to "ensure real ease of navigation", Naim says "just add a pair of speakers and it's ready to perform". The NaimUniti is available this month for £1995 - plus £95 for an n-link iPod connector, with Naim Audio's n-SAT satellite speakers angled as the "ideal match" priced at £770.Defining optimal therapy for muscle invasive bladder cancer. We defined an optimal curative strategy for muscle invasive bladder cancer and to determine how best to deliver curative therapy. We reviewed published reports from 1985 to 2006 dealing with the treatment of muscle invasive (stage T2-T4a) bladder cancer. We analyzed all cohort, phase II and randomized phase III studies providing level 1 to 3 evidence impacting survival. Cisplatin based chemotherapy combined with high quality radical cystectomy and complete pelvic lymph node dissection improves survival over that of cystectomy alone. Surgery quality is an important predictor of survival even in patients receiving chemotherapy. Neoadjuvant chemotherapy is favored over adjuvant chemotherapy because it is better tolerated and more patients are able to receive effective therapy before rather than after surgery. Neoadjuvant chemotherapy followed by radical cystectomy and complete pelvic lymph node dissection is the optimal curative strategy in most patients presenting with muscle invasive bladder cancer.Although the eighth annual Taste of Blaine at the National Sports Center Feb. 21 did not draw in as many people as it did last year, event organizers and restaurants were very happy with the new venue and how the event turned out....Read More The Coon Rapids Rotary Club invited all of its 2012 community grant recipients to the club’s weekly meeting where President Steve Rice handed out checks and gave the representative of each organization a chance to introduce themselves and their mission....Read MoreMy Name is Sarah MY NAME IS SARAH. I am a quilt designer and the sewcial director of Sarah's Sewcial Lounge. I also have a business called Down Right Charming. I sell my quilts mostly on etsy and I make pillowcases to donate to patients in the hospital in memory of my friend Kristen Kirton. I am a young adult living with Down syndrome. I hope you enjoy reading about my life journey. Monday, August 27, 2012 My Very Special Katie Weekend I had the greatest surprise this weekend. Do you remember when I was collecting coins in a jar for Katie? We were raising money in the store to help bring Katie home from Russia. Guess what? She came to see us this weekend. It was so exciting. Her whole family came all the way from Tennessee to meet me. Look at this. They brought me a shirt. We have a customer who is really going to like it when I wear this because she is from Tennessee too. At first Katie was a little shy. So I just sat in my chair and waited until she got used to me. First, she went to Katrina. She really liked her. Katrina is so nice. She is a nurse. We are so lucky she works with us on Saturdays. I think Katrina really liked Katie too. And then Katie went to my mom. My momma really liked that. They squeezed and hugged and I could tell my mom really loved Katie. Then she took her over in the corner and put a dress on her. We had been waiting for Katie to arrive to see if it would fit. It was made with fabric from our favorite designer Kate Spain. They share a name. Katie went over to the mirror to see herself. She loved the dress. And she loved looking at herself in the mirror. I don't think they had mirrors in the institution Katie lived in. She was so cute making faces at herself. Then we tried another dress on. She loved that one too. It fit perfectly. And then she came and sat in my lap. I melted. We just sat there for a long time. Katie was drawing. And I was holding her. And talking to her. We were having a good time. She liked my dog. We were talking about her being a smart little girl. She is talking a little bit. And she can follow directions. My mom told me she will learn really quick now that she is with her forever family. I am so happy for her. Katie and I started becoming friends. I don't think she knows that we both have Down syndrome. We started playing together. Katie loved drawing with this pencil set. I wished she lived closer to me. I would play with her all the time. I could not forget about Katie's brothers, Henry, Jack and David. They were so good waiting for us. So I gave them each a pillowcase I made. They have two dogs at home so we picked ones with dogs on them. Look at Jack. He is so silly. He put his pillow case on top of his head. I was so happy that Kim made all the plans to come see us. It was such a treat. Before they left, Flat Stanley had to pose with me and my sign. He gets to travel the world!!! On Sunday, I had to get up really early to go to the Apple store. We were signed up for the class. It turned out to be the wrong class. Darn. As we were walking out of the store, I told my mom I missed Katie already. She asked my how I was feeling. I said, "I feel fine mom." She said great. I have an idea. Next thing I know we are at the Cleveland Zoo. And K

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store and the fact that it tags absolutely everything in its collection, including vintage audio recordings, videos, photos and other media, Schulz explains. The actual content -- which is seldom accessed -- is ideally kept offline and on tape, Schulz says, with perhaps a thumbnail or low-resolution copy on disk. Today, the library holds around 500 million objects per database, but Youkel expects that number to grow to as many as 5 billion. To prepare, Youkel's team has started rethinking the library's namespace system. "We're looking at new file systems that can handle that many objects," he says. Gene Ruth, a storage analyst at Gartner, says that scaling up and out correctly is critical. When a data store grows beyond 10PB, the time and expense of backing up and otherwise handling that much data go quickly skyward. One approach, he says, is to have infrastructure in a primary location that handles most of the data and another facility for secondary, long-term archival storage. 2. Amazon.com E-commerce giant Amazon.com is quickly becoming one of the largest holders of data in the world, with around 450 billion objects stored in its cloud for its customers' and its own storage needs. Alyssa Henry, vice president of storage services at Amazon Web Services, says that translates into about 1,500 objects for every person in the U.S. and one object for every star in the Milky Way galaxy. Some of the objects in the database are fairly massive -- up to 5TB each -- and could be databases in their own right. Henry expects single-object size to get as high as 500TB by 2016. The secret to dealing with massive data, she says, is to split the objects into chunks, a process called parallelization. In its S3 storage service, Amazon uses its own custom code to split files into 1,000MB pieces. This is a common practice, but what makes Amazon's approach unique is how the file-splitting process occurs in real time. "This always-available storage architecture is a contrast with some storage systems which move data between what are known as 'archived' and 'live' states, creating a potential delay for data retrieval," Henry explains. Another problem in handling massive data is corrupt files. Most companies don't worry about the occasional corrupt file. Yet, when dealing with almost 450 billion objects, even low failure rates become challenging to manage. Amazon's custom software analyzes every piece of data for bad memory allocations, calculates the checksums, and analyzes how fast an error can be repaired to deliver the throughput needed for cloud storage. 3. Mazda Mazda Motor Corp., with 900 dealers and 800 employees in the U.S., manages around 90TB of data. Barry Blakeley, infrastructure architect at Mazda's North American operations, says business units and dealers are generating ever-increasing amounts of data analytics files, marketing materials, business intelligence databases, Microsoft SharePoint data and more. "We have virtualized everything, including storage," says Blakeley. The company uses tools from Compellent, now part of Dell, for storage virtualization and Dell PowerVault NX3100 as its SAN, along with VMware systems to host the virtual servers. The key, says Blakeley, is to migrate "stale" data quickly onto tape. He says 80% of Mazda's stored data becomes stale within months, which means the blocks of data are not accessed at all. To accommodate these usage patterns, the virtual storage is set up in a tiered structure. Fast solid-state disks connected by Fibre Channel switches make up the first tier, which handles 20% of the company's data needs. The rest of the data is archived to slower disks running at 15,000 rpm on Fibre Channel in a second tier and to 7,200-rpm disks connected by serial-attached SCSI in a third tier. Blakeley says Mazda is putting less and less data on tape -- about 17TB today -- as it continues to virtualize storage. Overall, the company is moving to a "business continuance model" as opposed to a pure disaster recovery model, he explains. Instead of having backup and offsite storage that would be available to retrieve and restore data in a disaster recovery scenario, "we will instead replicate both live and backed-up data to a colocation facility." In this scenario, Tier 1 applications will be brought online almost immediately in the event of a primary site failure. Other tiers will be restored from backup data that has been replicated to the colocation facility. Adapting the Techniques These organizations are a proving ground for handling a tremendous amount of data. StorageIO's Schulz says other companies can mimic some of their processes, including running checksums against files, monitoring disk failures by using an alert system for IT staff, incorporating metadata and using replication to make sure data is always available. However, the critical decision about massive data is to choose the technology that matches the needs of the organization, not the system that is cheapest or just happens to be popular at the moment, he says. In the end, the biggest lesson may be that while big data poses many challenges, there are also many avenues to success. This story, "Storage tips from heavy-duty users" was originally published by Computerworld.# Setup IDE: All Text Editor (Install as Python module) Tutorial Video is available on YouTube. Thanks **@GDquest** for creating a great tutorial video! [![](https://img.youtube.com/vi/IQgLBnPO2uo/0.jpg)](https://www.youtube.com/watch?v=IQgLBnPO2uo) #### 1. Check the generated modules location Check the location of the generated modules. #### 2. Install the modules as the Python module 1. Search and go to the directory `Python.exe` binary is installed. 2. Place the generated modules to the `Lib` directory. *Note: Be sure the Python version that you are using* So what: The company said it would be reporting a loss for the fourth quarter but no one expected an outlook of $0.67-$0.72 per share in losses. The company said that steel prices may fall 5% to drive the loss. To make matters worse, the company is offering $475 million in debt and 25-million shares of stock in new offerings. Now what: The bad outlook isn't positive but the company will add almost 25% to its shares outstanding with the share offering. Considering both factors, I think this is a stock I would stay far away from. Operating trends are heading in the wrong direction and I don't see any value in a company that's continually losing money. Interested in more info on AK Steel? Add it to your watchlist by clicking here.--- abstract: 'The Mission Accessible Near-Earth Object Survey (MANOS) aims to observe and characterize small (mean absolute magnitude H $\sim$ 25 mag) Near-Earth Objects (NEOs) that are accessible by spacecraft (mean $\Delta v \sim 5.7$ km/s) and that make close approaches with the Earth (mean Minimum Orbital Intersection Distance MOID $\sim$ $0.03$ AU). We present here the first results of the MANOS visible spectroscopic survey. The spectra were obtained from August 2013 to March 2018 at Lowell Observatory’s Discovery Channel 4.3 meter telescope, and both Gemini North and South facilities. In total, 210 NEOs have been observed and taxonomically classified. Our taxonomic distribution shows significant variations with respect to surveys of larger objects. We suspect these to be due to a dependence of Main Belt source regions on object size. Compared to previous surveys of larger objects [@Binzel_2019; @Binzel_2004; @Perna_2018], we report a lower fraction of S+Q-complex asteroids of $43.8 \pm 4.6\%$. We associate this decrease with a lack of Phocaea family members at very small size. We also report higher fractions of X-complex and A-type asteroids of $23.8 \pm 3.3\%$ and $3.8 \pm 1.3 \%$ respectively due to an increase of Hungaria family objects at small size. We find a strong correlation between the Q/S ratio and perihelion distance. We suggest this correlation is due to planetary close encounters with Venus playing a major role in turning asteroids from S to Q-type. This hypothesis is supported by a similar correlation between the Q/S ratio and Venus MOID.' author: - Maxime Devogèle - Nicholas Moskovitz - Audrey Thirouin - Annika Gustaffson - Mitchell Magnuson - Cristina Thomas - Mark Willman - Eric Christensen - Michael Person - Richard Binzel - David Polishook - Francesca DeMeo - Mary Hinkle - David Trilling - Michael Mommert - Brian Burt - Brian Skiff bibliography: - 'MANOS1.bib' title: 'Visible spectroscopy from the Mission Accessible Near-Earth Object Survey (MANOS): Taxonomic dependence on asteroid size ' --- Introduction {#sec:intro} ============ Near-Earth Objects (NEOs) are defined by a perihelion distance $q < 1.3$ AU. The study of NEOs provides access to objects up to 3 orders of magnitude smaller than the smallest observable Main Belt asteroids (MBAs), where most NEOs are thought to have originated. NEOs are also the most accessible objects

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and make love to three ladies in the course. In what order we would take the events it was for our own judgment to decide, but the Jew's horse was to belong to that one of us who arrived first at Baron Clootz's house after having fulfilled the conditions. "His proposition was a great success, and I was already in my mind arranging the consecutive order of the items, and going through my circle of acquaintances amongst the pretty women of the district, when I found that the day chosen for the contest was the day of my rendezvous with Madame Rosalba. The day had been chosen for both purposes from the same reason: because the élite of the town would be occupied, and not able to poke their noses into our affairs. "I had, however, confidence in myself, and as I walked away arm in arm with young Waldemar I thought it a good joke. He was still worshiping Rosalba from the footstep of her pedestal, so much so as to want to change his religion for her sake, even, I believe, and become a monk. I often had to listen to his panegyrics upon her. Still after some argument we had persuaded him to come into our contest. I think that he meant to show himself to Rosalba on the Spanish horse, for he was a tolerably good horseman. "I was, without vanity, punctual at my rendezvous at the white château of Rosalba on that Friday afternoon. By her own maid—for there was not another soul in the house; they had all gone to the funeral—I was taken to her boudoir in the tower, and at the top of a long stone stair. The shutters were closed, the room was half dark, and, when you came from outside, as cool as a church. There were a great many white lilies, so that the air was heavy with their scent. Upon a table were glasses, and a bottle of the best wine that I have ever tasted, a dry Château Yquem. This made my third bottle of the day. "Rosalba also was there. She was as ever very plainly attired, but she had shaken herself, with one shake, into very great beauty. "If what happened to me in this tower seems somehow wild and fantastical, and more like a fairy tale or a ghost story than a romance, the fault is not mine. It is true that the day was hot; a thunderstorm followed it in the night; and that as I came in from the white road, heavy in my riding boots, I was not too sure of my head. I may even have been more in love with her than I myself knew, for everything seemed to me to turn on her, and my bottles and my wildly galloped races to be only the reasonably fit initiatory ceremonies to this great moment of love-making. But I remember well all that happened. "I had not much time to give away. Light-headed as I was, with the room swinging up and down before my eyes, my words came easily to me, and I had her in my arms pretty soon, her clothes disheveled. She was like a lily in a thunderstorm herself, white and swaying, her face wet. But she held me back with her outstretched arms. 'Listen for one moment,' she said. 'Here we are all alone. There is no one in the house but we and my maid who brought you here, that pretty girl. Are you not afraid? " 'Arvid,' she said, 'have you ever heard the story of Don Giovanni?' She looked at me so intently that I had to answer that I had even heard that opera about him. 'Do you remember, then,' she said, 'the scene in which the statue of the Commandante comes for him? Such a statue there is on the tomb of the General Zumala, in Spain.' I said, 'Oh, let it keep him down in it, then.' " 'Wait,' said Rosalba. 'Rosalba belonged to General Zumala Carregui. When she betrays him, poor Rosalba must disappear. But then, an opera must have a fifth act to it sooner or later. And you, my star of the north, are to be the hero of it. You have your honor in the matter, as if you were a woman. You would have no mercy on St. Mary of Magdala. Rosalba was such a shining bubble, and when you break her, a little bit of wet will be all that you get out of it. But it was time that she went. The people, and her creator even, were becoming too fond of her. You give her her great tragic end. No other man in the world, I think, could have done that so well. You are well worthy of coming in.' " 'Let me come in, then,' I gasped. " 'You have no pity on poor Rosalba at all?' she asked. 'That she should lose her last refuge, and be haunted and doomed forever—that means nothing to you?' " 'You yourself have no pity on me,' I cried. " 'Ah, how much you are mistaken,' she exclaimed. 'For you, Arvid, I am worried, I am terribly sorry. An awful future awaits you—waste, a desert—oh, tortures! If I could help you, I would; but that is impossible to me. The thought of Rosalba will never be any good to you; her example cannot help you. The thought of this hour might, afterward, do you some good, but even that is not certain. Oh, my lover, if to save you I made you a present of a lovely horse, all saddled within my stable, fiery enough to carry you away in a gallop from this terrible fall and the perdition of us both, and if I sent my maid, that pretty girl who showed you up here, with you to find him, would you not go? " 'For soon,' she said, drawing herself up to her full height, her hand still on my breast, as mine in hers, and speaking in the manner of a sibyl, 'it may be too late, and we shall hear the fatal step on the stair, marble upon marble.' "In our agitation her dark hair, which used to hang down in ringlets on both sides of her face, was flung back, and I saw that she had indeed the brand of the witch upon her. From her left ear to her collar bone a deep scar ran, like a little white snake–" At these words of the Baron, Pilot cried out: "What! What are you saying?" "I said," said the Baron patiently, pleased with the impression made by his tale, "that from her left ear to the collar bone ran a scar, like a snake." "I heard it," cried Pilot. "Why are you repeating my words? The milliner of Lucerne, Madame Lola, had on her neck just such a scar, and I have this hour described it to you." "You have not said one word of it," said the Baron. "Have I not?" cried Pilot to me. I said nothing at all. I thought: I am dreaming. By now I am quite sure that I am dreaming. This hotel, Pilot, and the Swedish Baron are all parts of a dream. Good God, what a nightmare! I have at last lost my reason for good and all, and the next thing that will happen will be that Olalla will walk in through that door, swiftly, as she always comes in dreams. With that thought I kept my eyes on the door. From time to time, while we had been talking, new guests had come in from the outside, to sit down or to walk through the room to the inner apartments of the hotel. Now a lady and her maid came in, and passed us quickly and quietly. The lady wore a black cloak, which disguised her face and figure. The maid had her hair wrapped around her head in the Swiss way, and carried the shawls. Both looked so demure that not even the Baron gave them more than one glance. It was not till they were already gone that Pilot, suddenly stopping in his heated debate with the Baron, stood up like a statue, staring in their direction. When we asked him, laughing—for we had drunk enough to think one another ridiculous—what was the matter with him, he turned his big face toward us. "That," he cried, deeply moved, and even more so by the sound of his own voice, "was she. That was Madame Lola of Lucerne." The lightning of madness had struck, then, but it had hit Pilot and not me. Still no one could tell what would happen next; and indeed at his words it seemed to me that there had been something familiar about the lady. Pilot began to pull his hair. "Come, my boy," I said, taking hold of his arm. "It is not necessary to be mad. We will go together and ask the porter, who will know her, if this lady be not the midwife of Andermatt, who will be found to have nothing whatever in common with the Maid of Orléans." Still laughing, I dragged him to the porter's _loge_ and began to question the bald old Swiss about the newcomers. The porter was at first busy counting up various pieces of elegant luggage, and did not pay much attention to us. "Come," I said to him, "here is a

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alley. He stood there for two minutes, at the end of which he walked to the small table on which sat the ten small glasses of vodka. He picked up one of the glasses and knocked back the shot. When he finished he said to everyone, "Onwards to Charleston." Chapter 31: Gone in the Night The fundamental idea was that all of the conspiracy and planning, all the talking and risk-taking, and all of the strange friendships and relationships would result in some great action; this action being, of course, the theft; the heist of a lot of grade C artifacts from the Hermitage Museum in Saint Petersburg, Russia. This was not a Tom Cruise (Mission Impossible), Sean Connery (James Bond) type of action. Maybe it was a tribute to the brainpower employed by the team in its planning. Maybe it was luck. Maybe it was due to soft security by the Hermitage staff. Or maybe it was due to a legacy of bad karma drifting down through the years from the rampages of Lenin and Stalin. Who knows? The fact is, the heist went off without a hitch. The team did have to make one very important change to the plan at this point. After much discussion, mostly between Roger and Plouriva, they realized it simply wouldn't work having Roger describe to Plouriva beforehand the types of artifacts he wanted from the warehouses. He would have to be part of the heist team and choose the goods that were taken. Gwen didn't like this conclusion at all. She had planned on sitting comfortably in the Corinthia, playing with Roger and the towels that came off the heated towel rack she loved so much. Now her husband was walking into the line of fire. And it might turn out to be a withering fire. But she kept her mouth shut when it became clear Roger wanted to do this, and that it was necessary. Roger used their telepathy to tell her it was all right. On D-Day morning Roger went alone to the Hermitage, as usual. Just before lunchtime he left, and met Plouriva outside. She walked him to her office where he spent the remainder of the day, in full view of the grounds staff. Maybe they thought he was the boss' new squeeze, and if that was the case, the staff knew enough not to stick their noses into it. Early that morning Plouriva got a call from Constantine (on a secure line) saying eight large flatbed trucks were waiting at a construction site two miles from the museum. With this confirmed, Plouriva went into the main museum building and found her counterpart, the head hoity-toity guy that ran internal operations. She told him that today was the day to move the crates from Vladivostok out of the basement work areas, to the warehouse areas, where she would store them for the duration of the exhibit. He looked at her like she was crazy, and said, "Are you crazy? Why didn't you give me some notice?" She said, "Look, today is the day the construction guys I know off-loaded their trucks at their site. Today is the day the trucks are available. And so today is the day I can get the crates out of your way and out of your building. What's the problem? You want the crates to stay, fine by me." The hoity guy was exasperated, and looked it, but from past experience he knew enough to not fuck around with Plouriva. The last time he did that, his parking spaces didn't get plowed for two weeks from under a late May storm that dumped two feet of snow on the city. So he bit his lip, called down to the basement level and told the guys down there that today all the crates would be going. This stirred up a hive of activity that Plouriva was pleased to witness. The sixteen huge crates were cleared and lined up ready for loading. Plouriva went back to her office and smiled at Roger, who was looking at a Russian fashion magazine. He couldn't figure out why Plouriva, of all people, would have a magazine like this in her office, but he enjoyed looking at the Russian models. He was pleased to see the Russian fashion world had not succumbed to the disease the western fashion world has succumbed to, which is a population of emaciated, juvenile, stick-figure models. These Russian babes had substance to them. Plouriva called Constantine and spoke one word: "Go." At 2pm eight flatbeds entered the Hermitage compound through one of the service gates and rumbled up to the rear of the building that had 1285 rooms, including one heck of a lot of bathrooms. While the hoitys loaded the crates onto the trucks, Plouriva called the two gay guys and told them to stop by her office when they came on duty that evening at 6pm, because she had the forms they had asked for to apply for jobs in her division. This was the signal that the job was on for that night, as planned. She thought she heard choking at the other end of the phone line, but that could have been her imagination. She, on the other hand, was Cool Hand Luke. She was amazed she was not nervous, not even a little. Excited, maybe, but she had no premonition of disaster. When the head hoity called her and told her the crates were loaded, she jumped in her jeep and zoomed the quarter mile over to the museum. She parked, waved to the hoity, gave him the figure behind her back, and jumped on the running board of the lead truck. She gave the "convoy ho" signal, and the giant diesel engines chugged the trucks into motion. A massive cloud of smoke drifted towards the snow white walls of one of the great museums on the planet. The hoity guy said good riddance to the crates, and the same to the head grounds yahoo. The convoy meandered away from the museum area and disappeared into the surrounding pine forest. Most of the hoitys didn't know what went on out in "the woods", and didn't want to. Warehouses without end, dumpsites, a quarry, maintenance sheds, vehicle garages, water plants, sewage plants, and god knows what else filled these surrounding lands. This was Plouriva's territory. Plouriva's plan was to simulate a breakdown in the lead truck when it got to the warehouse district, when she did by opening the hood of the lead truck. She used an old military forklift to off-load two crates and make it look like they were heading for storage. The eight drivers and eight truck passengers hung around the area looking bored, in case any security patrols happened by, while two guys pretended to work on the lead truck engine. Plouriva had made sure that none of her staff would be working in this area. All was quiet. Plouriva hoofed it back a mile to her office complex and found Roger still looking at the fashion models. She wondered how long he could do this. It was 6pm, and most of the staff had left for the day. She called the security office and told them of the truck breakdown. They had nothing to say. With that, she turned to Roger and said the Russian version of, "Game on." Roger put down the magazine, looked at her, and said, "Now what." She turned off her computer, took a last look around the space that had been her office for twenty years, and with only a twinge of sentiment, flipped off the lights. They walked outside, hopped into another jeep, and disappeared into the forest. Plouriva drove to the warehouse complex and parked near the line of trucks. They got out, and Roger looked around. He counted thirty-one large, one-story, wood buildings within sight. He asked, "Is this all?" Plouriva got the American joke, and told him there were four other warehouse complexes similar to this. He said, "Wow." He looked at her, and she looked at him, and it dawned on them both that from this point forward the job would be shear improvisation. The sixteen guys lounging around showed no emotion; they had been part of heists before, and calmly waited for Plouriva's orders. All of them had paper bags of food, and all of them carried handguns under their shirts or on the floors of the trucks. From her jeep Plouriva grabbed a large pair of bolt-cutters and two flashlights. The warehouses were locked with large, heavy padlocks. Plouriva was solid as a rock as she led the way to the first building, cut the lock, and entered. The lights worked, surprisingly, as this may have been the first time in ten years that anyone had turned them on. Roger entered and looked around. The first thing he saw was a small painting of a Russian factory. The smokestack was billowing and the workers were filing in one doorway and out another. This was Russian realism from the 1950s. The painting was hanging by wires from one of the horizontal ceiling beams. Roger scanned the packed interior, with aisles running in perpendicular directions, and he looked at Plouriva for guidance. Plouriva had no guidance to provide, and shrugged her shoulders. With that as a statement of reality, Roger realized the same thing Jinny had realized a couple of days earlier, when he faced the task of dealing with the Hermitage perimeter security

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)?” Some will probably think Lenski fabricated her depiction of the Puritans from her own imagination. However, in the forward she carefully documents that much of her story is based upon assorted original sources and she includes an ample bibliography at the end. Of her sources, Lenski writes, “I have incorporated in my story many quotations taken from early New England writers. It is these phrases, so rich and suggestive, in the original sources, which give this long-past age a glow of reality and truth. In them we hear our founders speak, think, and act. They are the rightful heritage of American children (page XI).” Lenski also does a service to history by pointing out that, while the Puritans seem unduly harsh to us, in their time Christmas was marked by drunken bawdiness and in terms of severity Puritans were “soft” on crime as they had only ten crimes punishable by death whereas England had nearly thirty. In her trial before town authorities for introducing the children to Christmas, Shrovetide, and May Day, in her defense Charity Cummings says, “We came to this fair land to build a new world, a New England. If I then look back to the Old, if I remind you of the life we lived there, ‘tis because I wish to preserve the best in the old ways for a goodly heritage. So away with Old England’s wrongs, I beg you, but hold fast to its good, and make your new world the richer (215-216).” Likewise, we as their descendants should not dismiss the Puritans in their entirety but rather retain from them those dispositions that have withstood the test of time while guarding against those darker tendencies that in various forms have plagued mankind throughout all of recorded history and not just among the Puritans. Taken by itself, Puritan Adventure does not paint a complete picture of the pivotal contributions to the American way of life made by this sect. However, when studied alongside other introductory sources such as Pilgrims & Puritans by James and Lincoln Collier, the reader will have a good understanding of these complicated Forefathers. While the movement claims to support individuality, one of its leaders, Kevin Swanson, claims you are an materialistic existentialist if one does not follow his exact life-path and produce more than three children. If it is selfish not to have kids, why isn't it selfish to expect everyone else to take care of your offspring? He claims Hispanics have an above average birthrate since they have not been exposed as long to the American public school system. I wonder if this demographic would be as fecund if they were not given all manner of handouts such as WIC and free emergency medical care. Prepare for more coffee bars, electric guitars, and tattooed pastors with rings in their noses in a pulpit near you. From this article on the blog at Light House Publishing, the new head of this organization (Leith Anderson) might talk tolerance, but his minions are anything but as they prevented New Age expert Brian Flynn from discussing a number of mystical practices infiltrating the church. Wednesday, November 01, 2006 According to Dr. Albrecht the plan is essentially a food registration act that will permit the government near total control over the food supply and make it easier to drive the small farmer out of business. Big shots that usually dismiss such concerns who have so much extra money on their hands that they own horses might change their tune upon learning that there are provisions in these regulations that one must inform bureaucrats each time you take Trigger off your property. Furthermore, it is pointed out that those with registered animals will be required to keep a log of all visitors to their property to be turned over to the government encase of "disease outbreak". Why don't you enact a bowel movement and flatulence registration act while you are at it since toxins can be released into the atmosphere through this manner as well. Monday, October 30, 2006 Since a number of the trustees making this decision are members of Congress, does this mean if the American people employ tactics of a similarly seditious nature as the Gallaudet protestors that such members of Congress should be forced to resign? Wednesday, October 25, 2006 Tuesday, October 24, 2006 While Kevin Swanson does a good job of poitning out the failings of the socialistic public school system, frankly, I would not want to live in his brand of utopia either as in this edition of the program he believes girls should be married around 16 years of age and have 16 children over the course of their fecund years. While people did marry at ridiculously young ages years ago, they also died a whole lot earlier on average as well. I have seen pictures of my own great-grandmother who died in her mid 40's and she looked like she was pushing 70. Control by church authorities over matters not definitively spelled out in the Bible is still too much control. Monday, October 23, 2006 In an informative episode of his program dealing with the decline of manliness in our society, Albert Mohler complained that mostly women called in to discuss the issue. However, since his program is recorded at 5 pm, weren't the real men in America out working? Furthermore, isn't it the perceived epitome of feminity to yap one's trap about the inner recesses of one's feelings with someone you don't even know? Frankly, what manly man is going to want to do that on national radio? While a vital topic, at its conclusion, it veered to close towards sterotypical depictions of manhood rather than Biblical ones as it was insinuated hardware stores were a proper place for real men to hangout. Firstly, are those not given over to physical pursuits not to be viewed as manly; why aren't certain parts of the library considered sufficently masculine? For are not war and conflict as much about the mind as the body? Perhaps we should castigate as limpwristed those unfamiliar with sagas of adventure and the intricacies of critical thought if the same kinds of insinuations are going to fly about those lacking fetishes over power tools. Secondly, if someone is manly, frankly, they don't really need to be hanging around a group of men. If that's what one is craving to do, in my opinion that is itself a sign that one might secretly not be as brawny as one tries to lead others to believe and actually a bit of a flake at heart. Saturday, October 21, 2006 Two of comicdom’s most legendary characters are none other than Superman and Captain Marvel, more popularly known as Shazam. To the unfamiliar, at first glance the two heroes seem almost indistinguishable from one another with Captain Marvel wearing the spiffier costume while Superman possesses the more iconic insignia. Superman/Shazam: First Thunder chronicles a contemporary interpretation of the first meeting between the World’s Mightiest Mortal and the Man of Steel. And though not the best-drawn story featuring these characters that have both been around since the early days of comic books, this graphic novel provides a bit of insight into the differences between the two. For example, from a dialogue between these foremost costumed adventurers, the reader learns that while Superman might have superior senses, Captain Marvel is more immune to the effects of magic. It is doubtful Superman/Shazam: First Thunder will be remembered as a graphic novel classic. However, fans will nevertheless get a kick out of seeing these legends team up. Monday, October 16, 2006 In a classic Simpsons’ moment, at their show’s equivalent of Disney World dedicated to the parodies of Tom and Jerry known as Itchy and Scratchy, a giddy Homer is duped into trading his money for the amusement park’s imitation play currency which can’t be spent on anything at the park. The scene is humorous in that only Homer would be among those stupid enough to fall for such a scheme. At one time, it use to be a sign of discernment if the prudent citizen was not taken in by such snake oil. However, if a bunch of grubby beatniks have their way, one’s willingness to fall for such nonsense will serve as a measure of one’s devotion to and support of the COMMUNITY. According to the June 2006 Hyattsville Life And Times, the cities of Hyattsville, Mount Rainier, and Brentwood will be acquiring a local currency to be called the “Anacostia Hour”. Those hoodwinked into accepting this tender can use it to purchase goods from businesses part of the program and even pay employees “willing” to accept this glorified monopoly money. The purpose of this dubious means of exchange as stated in the Hyattsville Life & Times is to “keep people shopping in the local community.” Maybe if a given municipality had stores worth shopping at or free from the dregs of humanity prowling the aisles of such establishments, residents wouldn’t mind spending their regular money in the area. But bigshots in these here parts insist upon either “high end retailers” or idiosyncratic specialty merchants selling novelty junk common folks have little need of. Furthermore, in a market economy, it is not the business of any collection of individuals from where I acquire goods and provisions classified as legitimate in a free society. For while these proposals are often packaged in terms of civic enthusiasm, they are merely contrived gu

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the past year and a quarter, it had captured 66 German spy handlers and 1,596 German agents, including 1,338 in western Ukraine, Belarus, and the Baltics, with hundreds of incidents of live fire at the border. Over the first four months of 1941, at least 17,000 trains were reported to have ferried German troops and heavy weapons to Soviet frontiers. Was it certain war? Internally, the British had dismissed the intelligence regarding Hitler's preparations for a war against the Soviet Union, but now, thanks to the Enigma decoding, they had discovered that Hitler was ordering more and more of the Luftwaffe transferred eastward, away from bombing sites for the UK. Still, the British attributed the eastern buildup to a "war of nerves" being waged to force concessions from Stalin. Stalin knew that the Germans had ceased using the Trans-Siberian to transport their diplomatic pouches to and from Tokyo, and Sorge reported (April 17) that the Germans would also cease to use the Trans-Siberian for the import of critical rubber from Japan. But Sorge undercut this message, noting that "the tension in relations between Germany and the USSR was decreasing," which meant the Germans might not follow through on their intention to cease using the Trans-Siberian. He also wrote of supposed factionalism within Nazi ruling circles and suggested that the "pro-war faction" had not gained ascendancy. Sorge added: "The German embassy [in Tokyo] received a telegram from Ribbentrop stating that Germany would not launch a war against the USSR if the latter did not provoke it. But if the war turned out to be provoked, then it would be short and end with the severe defeat of the USSR. The German general staff has completed all preparations." On April 22, Sándor Radó ("Dora"), a Hungarian Communist and Soviet military intelligence operative, reported from Geneva a date of June 15 for an attack on Ukraine. On April 23, Stalin and Molotov decreed the formation of large numbers of new artillery and parachute units with forced production of equipment. The next day, Stalin phoned Ilya Ehrenburg to tell him that the second and third parts of his anti-German novel, _The Fall of Paris,_ would now be published. Only four days earlier, Ehrenburg had been informed that the censor had rejected it. Rumors spread that the despot had personally approved the antifascist book. On April 25, Golikov estimated the presence of 100 German divisions on the USSR's western frontiers, an increase from the previous month. On April 25–26, some three and a half months into his work, Tupikov sent a long message to Golikov on Germany's buildup in the east, stating plainly that the Soviets were the "next enemy" in German war planning, and that "the timing for the beginning of a conflict could possibly be near and, for sure, during the course of this year." A worried Schulenburg, in mid-April, had engaged his staff to draft a long memorandum arguing against a titanic war and, with the facilitation of Ribbentrop and Weizsäcker, who also thought the war a mistake, had traveled to Berlin, but Hitler put off seeing him for two weeks. Finally, on April 28, the Führer granted an audience. Schulenburg's memo was sitting on Hitler's desk (he made no mention of it). Schulenburg evidently stated that "Stalin was prepared to make even further concessions to us," including ramping up to 5 million tons of grain the next year. In fact, Mikoyan could barely find, let alone transport, 2.5 million tons of grain, and it was not clear how the Germans could pay for more grain without yielding vital armaments. Hitler, noncommittal and discourteous, said at parting, "Oh, one more thing: I do not intend a war against Russia!" In London, Maisky was effectively paralyzed by Stalin's position vis-à-vis Britain. On April 30, Churchill's private secretary told the Soviet envoy, "In Conservative circles, one hears the following argument. If Germany attacks the Soviet Union (as many now believe will happen), the USSR will come to us of its own accord. If Germany does not attack the USSR, it will do nothing for us anyway. So is it worth courting the USSR?" Maisky burst out laughing. That same day, "Elder" reported to Moscow, based on conversations in Göring's air ministry with the liaison to the foreign ministry, that "the question of the German attack against the USSR has been definitively decided and its onset can be expected any day. Ribbentrop, who until now had not been a supporter of an offensive against the USSR, knowing Hitler's firm resolve on this question, has taken the position of support for an attack on the USSR." "Elder" was spot-on: that very day, Hitler settled on a date fifty-three days hence—June 22. Neither the German invasion of Greece ("Marita") to compensate for Mussolini's failures nor of Yugoslavia (Operation "25") had a material effect on Barbarossa. Many of the divisions earmarked to take part in the Balkans never saw fighting; some were never even sent. Before May was over, all German units that had taken part in the Balkan campaign were back at their positions on the Soviet border. The delay by about five weeks from the original target stemmed mostly from deficits of key equipment in what, after all, was a colossal undertaking. Indeed, "Corsican" had reported (April 28) that Germany was experiencing severe shortages—and therefore would need to expand economic relations with Japan and the Soviet Union, in the latter case "by force." He had heard one top German official state that "the Russians must supply Germany with more raw materials and foodstuffs, without demanding that Germany had to fulfill Soviet orders exactly or by short deadlines." "Elder," too, reported the possibility of Germany engaging in blackmail. The ultimatum canard—which never formed part of Hitler's plans—had contaminated even the best-placed, most reliable Soviet spies. ### NO ARMY IS INVINCIBLE On May 4, Hitler delivered a peroration to the Reichstag detailing how he had smashed Poland, Norway, Belgium, Holland, France, Yugoslavia, and Greece. "The German armed forces have truly surpassed even themselves," he bragged. "Infantry, armored, and mountain divisions, as well as SS formations, battled without rest, in bravery, endurance, and tenacity to achieve their goals. The work of the general staff has been outstanding. The air force has added new heroic deeds to its historic glory. . . . Nothing is impossible for the German soldier!" He concluded: "The German Reich and its allies constitute a power that no coalition in the world can surpass. German armed forces will unremittingly intervene in the course of events whenever and wherever it will be required." The signals were getting even more confounding. In Tokyo, the day after Hitler spoke, Japanese foreign minister Matsuoka reassured German ambassador Ott that "no Japanese prime minister or foreign minister could ever be able to maintain Japan neutrality in the event of a conflict between Germany and the Soviet Union. In such an event, Japan, naturally, would be compelled to attack Russia right behind Germany." That would have violated the Soviet-Japanese Neutrality Pact, and it did not comport with Japan's internal deliberations. That same day, a dispatch from "Corsican" in Berlin went to Moscow indicating that a press person from the German economics ministry had told the staff that Germany wanted peace on its eastern frontiers, for it would soon attack the British-controlled Suez Canal. Germany would demand that the USSR attack Britain on the side of the Axis, and, as a guarantee that Moscow would follow through, Germany was going to occupy Ukraine and possibly the Baltics. Stalin decided to send some signals of his own. Also on May 5, 1941, at 6:00 p.m., Timoshenko opened the graduation ceremony in the Grand Kremlin Palace's combined Andreyev-Alexander hall (the venue for party congresses) for sixteen military academies and nine military departments in civil institutions, with some 1,500 attendees, including professors as well as defense commissariat, government, and Comintern personnel. The graduates had entered the academies in 1937 or 1938. When Timoshenko announced that Stalin would take the dais, the eruption would not die down until the despot glanced at Timoshenko, who quieted the hall. "Comrades, permit me in the name of the Soviet government and the Communist party to congratulate you on the completion of your studies and wish you success in your work," Stalin began, going on to underscore, over the course of forty minutes, the enormous strides in the Red Army's material base. But he criticized the academies' curriculum. "I have an acquaintance who studied at the Artillery Academy," Stalin noted. "I looked over his notes and discovered that a great deal of time is being spent studying cannons that were decommissioned in 1916." This acquaintance was his elder son, Yakov, who was in the audience. "Is it like that, comrade artillerymen?" Shockingly, Lieutenant General Arkady Sivkov, head of the Artillery Academy, shouted from one of the front rows that the school's curriculum was based on modern weaponry. "I ask that you do not interrupt me," Stalin answered. "I know what I am saying. I read the notes of a student of your academy." Stalin devoted most of his remarks to the Red Army's technological transformation.

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string body, string attachment) needs a string type for the argument attachment. Whereas you're passing an object of type StorageFile, which you get by calling await folder.GetFileAsync(name); If you want to pass the file path of the attachment you can do: await kioskclient.sendEmailWithAttachAsync(email_address, "Visit Photo", message, file.Path); Practical Scriptwriter Practical Scriptwriter is screenwriting software supporting various US and UK script formats (Stage, Screen, Television and Radio) as required by the BBC and US Screenwriting industry standards. The software runs on the Windows platform only. The application is notable due to the separation of formatting information from the script itself. This separation is the opposite of a traditional WYSIWYG Word Processor, the data file format does not contain font and layout metadata, this is only applied during the formatting process. The software uses a proprietary file format identified by the .FSC file extension. Originally released in 2005, the software was rewritten using Windows Presentation Foundation in 2012. References Category:Screenwriting software Category:Windows text-related softwareA full duplex radio (FDR) or full duplex communication scheme refers to a communication scheme for simultaneously supporting transmission and reception using the same resource in one user equipment (UE). In this case, the same resource refers to the same time and the same frequency. FDR communication or full duplex communication is referred to as two-way communication. FIG. 1 is a conceptual diagram illustrating a UE and a base station (BS), which support FDR. Referring to FIG. 1, in a network state that supports FDR, there are three types of interferences. First interference is intra-device self-interference. The intra-device self-interference means that signals transmitted from a transmission (Tx) antenna and received by a receiving (Rx) antenna act as interference in one BS or UE. Since the signals transmitted from the Tx antenna are transmitted with high power and a distance between the Tx antenna and the Rx antenna is short, the transmitted signals are received by the Rx antenna without almost of attenuation, and thus, are received with higher power than a desired signal. Second interference is UE to UE inter-link interference. In a network that supports FDR, the UE to UE inter-link interference is increasingly caused. The UE to UE inter-link interference refers to interference caused by uplink signals that are transmitted from a UE and received by a neighboring UE. Third interference is BS to BS inter-link interference. Similarly, in a network state that supports FDR, BS to BS inter-link interference is increasingly caused. The BS to BS inter-link interference refers to interference caused by signals that are transmitted between BSs or heterogeneous BSs (pico, femto, and relay) in a HetNet state and received by an Rx antenna of another BS. Among the three types of interferences, the intra-device self-interference (hereinafter, referred to as self-interference) is influence of interference caused only in FDR. In order to manage FDR, the most serious problem is cancellation of self-interference.Gibson Freezer Parts Need Help? Get Questions Answered Instantly. 1-877-477-7278 The Gibson appliance brand began as a merger between two icebox manufacturing companies in Michigan in 1908. It has evolved mightily since that time, and is currently a well-respected division of Electrolux. From the first upright freezer in 1946 to its current, varied energy efficient models found in homes throughout America, Gibson freezers -- both upright and chest -- continue to be recognized for outstanding capacity, ease of use, and performance. Whether you've lost your freezer lock key, you need a new deodorizer, your door handle is damaged, or an integral component like a defrost thermostat or compressor needs to be replaced so your food stays chilled, we have the Gibson freezer part selection and guidance to help solve your problem.1898–99 Scottish Cup The 1898–99 Scottish Cup was the 26th season of Scotland's most prestigious football knockout competition. The Cup was won by Celtic when they beat Rangers 2-0 in the final. Calendar First round First round replay Second round Second round replay Second round second replay Quarter Final Game Abandoned Quarter Final replay Semi-finals Final See also 1898–99 in Scottish football References RSSF Scottish Cup 98-99 1899-1900 Cup CupTORONTO -- Netflix says it's planning on cracking down on users who use virtual private networks and proxy services to view content not available in their countries. Many of the company's distribution deals with major studios and content providers are negotiated on a regional basis, meaning certain titles are only available to users in certain countries. Some Canadians use VPN services to stream Netflix movies and TV shows available in the United States, which according to the website Netflixable has around twice as many available titles. The U.S. version of Netflix also features more Hollywood blockbusters and recent seasons of popular network shows than its Canadian counterpart. In a blog post, David Fullagar, Netflix's vice-president of content delivery, said the company is making progress in licensing content across borders but is now implementing new measures to end the use of so-called unblockers and other proxy services. The company has always been against the use of such services and has said it takes measure to shut them down, but Fullagar said the company is "evolving" its approach to the problem and the new strategy will be in place in the coming weeks. According to a April 2015 report by Media Technology Monitor, roughly two in five English-speaking Canadians has a subscription to the video-streaming service, with nearly one-third saying they had accessed the American version of the service.Category Archives: QA Some people describe addiction as a spiritual disease as much as it is a mental, emotional or physical one. Just like depression and other mental illnesses, addiction can be seen as being a deep disconnect within us that severs our connection with our higher power as well as the interconnectedness of our different parts. We… For those living with addiction, many of us experience what we often refer to as hitting “rock bottom,” that time and place where we feel we’ve fallen as low as we possibly can. In this place, there are some common things many of us think, feel and experience that are memorable and that stay with… Although depression is a debilitating and paralyzing mental illness, it often goes undiagnosed and therefore untreated. There are a number of reasons why we never reach out for help, many of them having to do with the stigma that still surrounds addiction in our society and in our communities. There is still a common misconception… There are many factors that can contribute to our addictions – our family’s experience with substance abuse, our genetic makeup, our mental illnesses and our lack of healthy emotional coping skills. One factor we often ignore but that can be particularly problematic is boredom. When we think of boredom, we think of it as being… A popular wellness trend is decluttering, clearing away the chaos and confusion in our physical spaces, in our lives, and in our minds. When we declutter, we take mindful steps to simplify both our surroundings and our internal environment. We look at what elements are holding us back, in our daily lives, in our homes,… A huge contributor to our addictions and mental health issues is our lack of self-worth. We feel insecure about who we are, about our illnesses, about where we are in our lives. We feel ashamed of ourselves. Our shame and lack of self-worth make us think we don’t deserve to be happy or experience the… When we’re struggling with addiction, the logical thing would be to want to get help for the illness that is destroying our lives. When we have a broken bone or any other medical issue, we get help. Why do we so often resist getting the help we need to kick our addictions? What is it… As parents, our children’s well-being is of the utmost importance to us and is usually our highest priority. We are responsible for their upbringing and their health, and we take our responsibility very seriously. We feel honored to be their parents. When we’re struggling with addiction, our priorities can become totally skewed. The toxic substances… Those of us living with addiction know just how painful and overpowering addiction can be. We get caught in cycles of using, desperately wanting to quit, feeling remorseful and depressed about our substance use and our inability to stop, quitting for awhile, and then falling right back into using again. This cycle can repeat itself… If you are struggling with thoughts of suicide, PLEASE call the National Suicide Prevention Lifeline: 1-800-273-TALK (8255). Self-medicating is the term used to describe our use of addictive substances and behaviors to relieve our mental and emotional pain. Rather than actual medication or natural remedies that would help us to heal, we’re relying on toxic…Q: MongoDB field level encryption with Lambda and Atlas how to include mongocryptd I try to implement MongoDB client field level encryption with an Atlas M10 cluster and AWS lambda. As far as I understand I would need to have the mongocryptd binary in my path which. How can I bundle this binary with lambda? A: You can use Lambda Layer in order to package your dependencies. The L

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addictive FPS fare: Collect power-ups, armor and weapons as quickly as possible, turn your enemies into piles of pixelated goo and repeat. Sounds simple, yes, but also endlessly appealing and difficult to master. The only hitches found currently are the lack of certain features (now that the 30 minute to one hour queues of last week are gone) such as some forms of stat tracking and a few of the achievements that have been taken down temporarily. Other than these few bumps in the road, Quake Live succeeds as a beta because if you missed the word “beta” below the game’s current logo, you would barely notice it’s a beta test at all. There are no words from id Software on an official release, but expect it to be a while before Quake Live moves on from beta as there are plenty more features id Software are planning to add. Can someone say “premium accounts“? Check back for future updates. (Images via Gamers Lab & Games Radar)PALO ALTO — Maryam Mirzakhani was best known for breaking the mold — and for doing it the hard way. As a high school student in her native Iran, Mirzakhani competed for the International Mathematical Olympiad in the 1990s– a competition in which girls seldom participated. Related Articles Stanford professor first woman to win Fields Medal Years later, the world-renowned mathematician, by then a Stanford professor, became the first and only woman to receive the prestigious Fields Medal, often described as the mathematician’s Nobel Prize. Mirzakhani, who lost her long battle with breast cancer on Saturday at age 40, was described by her colleagues as a remarkable mathematician whose skill and passion was unmatched. “Maryam is gone far too soon, but her impact will live on for the thousands of women she inspired to pursue math and science,” said Stanford President Marc Tessier-Lavigne. “Maryam was a brilliant mathematical theorist and also a humble person who accepted honors only with the hope that it might encourage others to follow her path. “Her contributions as both a scholar and a role model are significant and enduring, and she will be dearly missed here at Stanford and around the world.” The eight-decade-old Fields Medal is given every four years to no more than four mathematicians, all of whom are 40 or younger. Mirzakhani, a Palo Alto resident, received the award in 2014 in Seoul, South Korea. “This is a great honor. I will be happy if it encourages young female scientists and mathematicians,” she said at the time. “I am sure there will be many more women winning this kind of award in coming years.” Mirzakhani — known for willingly taking the difficult, complicated path to solve a mathematical problem — studied the symmetry of curved surfaces and other theoretical concepts known as “pure mathematics.” In 2008, she joined Stanford, where she taught mathematics until her death. French mathematician Cédric Villani called Mirzakhani an “emblematic figure for Iran and for women in science.” “Beautiful mind, beautiful soul, wonderful woman,” he said on Twitter Saturday. Mirzakhani gained international recognition after winning a gold medal in Iran’s International Mathematical Olympiad in 1994. The following year she nailed a perfect score and two gold medals. Like our Facebook page for more conversation and news coverage from the Bay Area and beyond. She went on to college at Sharif University in Tehran and then graduate school at Harvard University, where she was guided by Fields Medal winner Curtis McMullen, who once said she was filled with “fearless ambition.” At Harvard, she was known for her persistence and intense questioning, despite a language barrier. “To see the kind of courage she demonstrated in saying, ‘This is cool stuff, I want to do it and I can do it,’ is just amazing to me,” said Dana Mackenzie, a mathematics and science writer who lives in Santa Cruz. “From the very beginning she’s been a star.” Mirzakhani’s 2004 dissertation, in which she solved two longstanding problems and connected the two into a masterful thesis, catapulted her into even greater fame. It yielded papers in each of the top three mathematics journals. “The majority of mathematicians will never produce something as good,” said Benson Farb, a mathematician at the University of Chicago. “And that’s what she did in her thesis.” Most recently, Mirzakhani collaborated with Alex Askin at the University of Chicago on one of the field’s most perplexing problems: the trajectory of a billiards ball around a polygonal table. The resulting work was hailed as “the beginning of a new era” in mathematics. “It’s a day of mourning for mathematics,” Mackenzie said. “She was one of the brightest mathematicians of her generation, and it’s always just a really sad thing when somebody like that leaves too early.” Reading this on your phone? Stay up to date with our free mobile app. Get it from the Apple app store or the Google Play store. Mirzakhani was a professor at Princeton University and a research fellow at the Clay Mathematics Institute before joining the Stanford faculty. She leaves her husband, Jan Vondrák, and a daughter, Anahita./* * Copyright 2020 ZUP IT SERVICOS EM TECNOLOGIA E INOVACAO SA * * Licensed under the Apache License, Version 2.0 (the "License"); * you may not use this file except in compliance with the License. * You may obtain a copy of the License at * * http://www.apache.org/licenses/LICENSE-2.0 * * Unless required by applicable law or agreed to in writing, software * distributed under the License is distributed on an "AS IS" BASIS, * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. * See the License for the specific language governing permissions and * limitations under the License. */ package formula import ( "path/filepath" "runtime" "strings" "github.com/google/uuid" "github.com/ZupIT/ritchie-cli/pkg/api" "github.com/ZupIT/ritchie-cli/pkg/os/osutil" ) const ( ReposDir = "repos" TmpDir = "tmp" DefaultConfig = "config.json" PwdEnv = "CURRENT_PWD" CtxEnv = "CONTEXT" VerboseEnv = "VERBOSE_MODE" BinUnix = "run.sh" BinWindows = "run.bat" BinDir = "bin" EnvPattern = "%s=%s" ) type ( Input struct { Name string `json:"name"` Type string `json:"type"` Default string `json:"default"` Label string `json:"label"` Items []string `json:"items"` Cache Cache `json:"cache"` Condition Condition `json:"condition"` Tutorial string `json:"tutorial"` Required *bool `json:"required"` } Cache struct { Active bool `json:"active"` Qty int `json:"qty"` NewLabel string `json:"newLabel"` } Condition struct { Variable string `json:"variable"` Operator string `json:"operator"` Value string `json:"value"` } Create struct { FormulaCmd string `json:"formulaCmd"` Lang string `json:"lang"` WorkspacePath string `json:"workspacePath"` FormulaPath string `json:"formulaPath"` } Config struct { DockerIB string `json:"dockerImageBuilder"` Inputs []Input `json:"inputs"` } // Definition type that represents a Formula Definition struct { Path string RepoName string } Setup struct { Pwd string FormulaPath string BinName string BinPath string TmpDir string Config Config ContainerId string } Help struct { Short string `json:"short"` Long string `json:"long"` } ExecuteData struct { Def Definition InType api.TermInputType RunType RunnerType Verbose bool } ) type Creator interface { Create(cf Create) error } type MakeBuilder interface { Build(formulaPath string) error } type ShellBuilder interface { Build(formulaPath string) error } type BatBuilder interface { Build(formulaPath string) error } type DockerBuilder interface { Build(formulaPath, dockerImg string) error } type LocalBuilder interface { Build(workspacePath, formulaPath string) error } type Wat

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uceFunction<SensorReading> { public SensorReading reduce(SensorReading r1, SensorReading r2) { return r1.value() > r2.value() ? r2 : r1; } } private static class MyProcessWindowFunction extends ProcessWindowFunction<SensorReading, Tuple2<Long, SensorReading>, String, TimeWindow> { public void process(String key, Context context, Iterable<SensorReading> minReadings, Collector<Tuple2<Long, SensorReading>> out) { SensorReading min = minReadings.iterator().next(); out.collect(new Tuple2<Long, SensorReading>(window.getStart(), min)); } } ``` ``` val input: DataStream[SensorReading] = ... input .keyBy(<key selector>) .timeWindow(<duration>) .reduce( (r1: SensorReading, r2: SensorReading) => { if (r1.value > r2.value) r2 else r1 }, ( key: String, window: TimeWindow, minReadings: Iterable[SensorReading], out: Collector[(Long, SensorReading)] ) => { val min = minReadings.iterator.next() out.collect((window.getStart, min)) } ) ``` #### 使用AggregateFunction进行增量窗口聚合以下示例显示如何将增量`AggregateFunction`与a组合`ProcessWindowFunction`以计算平均值，并同时发出键和窗口以及平均值。 * [**Java**](#tab_java_10) * [**Scala**](#tab_scala_10) ``` DataStream<Tuple2<String, Long>> input = ...; input .keyBy(<key selector>) .timeWindow(<duration>) .aggregate(new AverageAggregate(), new MyProcessWindowFunction()); // Function definitions /** * The accumulator is used to keep a running sum and a count. The {@code getResult} method * computes the average. */ private static class AverageAggregate implements AggregateFunction<Tuple2<String, Long>, Tuple2<Long, Long>, Double> { @Override public Tuple2<Long, Long> createAccumulator() { return new Tuple2<>(0L, 0L); } @Override public Tuple2<Long, Long> add(Tuple2<String, Long> value, Tuple2<Long, Long> accumulator) { return new Tuple2<>(accumulator.f0 + value.f1, accumulator.f1 + 1L); } @Override public Double getResult(Tuple2<Long, Long> accumulator) { return ((double) accumulator.f0) / accumulator.f1; } @Override public Tuple2<Long, Long> merge(Tuple2<Long, Long> a, Tuple2<Long, Long> b) { return new Tuple2<>(a.f0 + b.f0, a.f1 + b.f1); } } private static class MyProcessWindowFunction extends ProcessWindowFunction<Double, Tuple2<String, Double>, String, TimeWindow> { public void process(String key, Context context, Iterable<Double> averages, Collector<Tuple2<String, Double>> out) { Double average = averages.iterator().next(); out.collect(new Tuple2<>(key, average)); } } ``` ``` val input: DataStream[(String, Long)] = ... input .keyBy(<key selector>) .timeWindow(<duration>) .aggregate(new AverageAggregate(), new MyProcessWindowFunction()) // Function definitions /** * The accumulator is used to keep a running sum and a count. The [getResult] method * computes the average. */ class AverageAggregate extends AggregateFunction[(String, Long), (Long, Long), Double] { override def createAccumulator() = (0L, 0L) override def add(value: (String, Long), accumulator: (Long, Long)) = (accumulator._1 + value._2, accumulator._2 + 1L) override def getResult(accumulator: (Long, Long)) = accumulator._1 / accumulator._2 override def merge(a: (Long, Long), b: (Long, Long)) = (a._1 + b._1, a._2 + b._2) } class MyProcessWindowFunction extends ProcessWindowFunction[Double, (String, Double), String, TimeWindow] { def process(key: String, context: Context, averages: Iterable[Double], out: Collector[(String, Double]): () = { val average = averages.iterator.next() out.collect((key, average)) } } ``` #### 使用FoldFunction进行增量窗口聚合以下示例显示如何将增量`FoldFunction`与a组合`ProcessWindowFunction`以提取窗口中的事件数，并返回窗口的键和结束时间。 * [**Java**](#tab_java_11) * [**Scala**](#tab_scala_11) ``` DataStream<SensorReading> input = ...; input .keyBy(<key selector>) .timeWindow(<duration>) .fold(new Tuple3<String, Long, Integer>("",0L, 0), new MyFoldFunction(), new MyProcessWindowFunction()) // Function definitions private static class MyFoldFunction implements FoldFunction<SensorReading, Tuple3<String, Long, Integer> > { public Tuple3<String, Long, Integer> fold(Tuple3<String, Long, Integer> acc, SensorReading s) { Integer cur = acc.getField(2); acc.setField(cur + 1, 2); return acc; } } private static class MyProcessWindowFunction extends ProcessWindowFunction<Tuple3<String, Long, Integer>, Tuple3<String, Long, Integer>, String, TimeWindow> { public void process(String key, Context context, Iterable<Tuple3<String, Long, Integer>> counts, Collector<Tuple3<String, Long, Integer>> out) { Integer count = counts.iterator().next().getField(2); out.collect(new Tuple3<String, Long, Integer>(key, context.window().getEnd(),count)); } } ``` ``` val input: DataStream[SensorReading] = ... input .keyBy(<key selector>) .timeWindow(<duration>) .fold ( ("", 0L, 0), (acc: (String, Long, Int), r: SensorReading) => { ("", 0L, acc._3 + 1) }, ( key: String, window: TimeWindow, counts: Iterable[(String, Long, Int)], out: Collector[(String, Long, Int)] ) => { val count = counts.iterator.next() out.collect((key, window.getEnd, count._3)) } ) ``` ### 在ProcessWindowFunction中使用每窗口状态除了访问被Keys化状态（如任何丰富的函数可以），a `ProcessWindowFunction`还可以使用被Keys化状态，该被Keys化状态的作用域是函数当前正在处理的窗口。在这种情况下，了解_每个窗口_状态所指的窗口是很重要的。涉及不同的“窗口”： * 指定窗口算子操作时定义的窗口：这可能是_1小时的翻滚窗口_或_滑动__1小时__的2小时滑动窗口_。 * 给定键的已定义窗口的实际实例：_对于

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Size: The size of this unit is larger than many other models. You may need to get a deep enough container or else it may not fit well into smaller containers. Common opinion holds that this circulator is best suited for medium to large sized containers and nothing smaller. Cost The cost of the Chefman Sous Vide is one of its attractive features. It is available on Amazon for $69.99. This is a great price for technology of this sort. Also, there is a gift wrap option available when you buy it from Amazon. This lets you get it as a gift for a newly married couple or a relative who loves cooking. What are customers saying? Customer reviews indicate that this is a popular sous vide immersion circulator. People who have bought this device like its easy usability and consistent results. Another perk is its very affordable price tag compared to other similar products. This immersion circulator offers all the basic functions as many other more expensive models without having to break the bank. However, there have been some serious complaints about getting defective units in the mail. That said, customer service has been quick to replace broken/ defective items. Some customers feel that the final beeping sound when the food is done is barely audible and they’ve had to use other timers instead. Should you get it? The Chefman immersion circulator is suitable for both beginner and professional sous vide cooks. However, you have to remember that sous vide is a slow cooking method. If you’re okay with waiting and letting your food cook for hours, then this is a good investment. The price, ease-of-use and customer support make it worth the wait. But if you don’t have time to wait for your meals, then you could consider another, faster cooking method. Conclusion The Chefman Sous Vide Immersion Circulator is equipped with all the features that a device of this sort should have. Judging from the positive reviews, we can say that this kitchen appliance is a promising one. Keeping things very simply and easy, the Chefman Sous Vide can really help make any recipe better. If you want to get the same delicious results every time with your cooking, then this immersion circulator is a great investment. As sous vide slowly reaches domestic settings from restaurants, a good precision cooker has become the need of the hour. And as more and more people become familiar with the concept of sous vide cooking, the demand for immersion circulators and sous vide cookers is on the rise. Given this demand, many companies have released their best equipment for this cooking technique. Here, we discuss some of the best precision cookers, in terms of effectiveness and popularity that are in the market at the moment. Here’s a quick look at what each one offers before going into details: Do you want to nail a Thanksgiving turkey or steak in your first attempt? Or perhaps you want to make cooking easier than conventional methods? If you wish to do so, then the Anova Precision cooker is your best friend in the kitchen. The manufacturers claim that the results you get with their device cannot be achieved by any other cooking method. Keeping aesthetics and performance in mind, the manufacturers have put together a sous vide device that is highly stylish yet simple to use. With a fairly simple interface, a highly functional clamp and a precision cooking mechanism, you can’t go wrong with this device. With an 800 Watt motor, the Anova precision cooker circulates water in the container at high speed ensuring that the heat seeps into the food from all sides. This also saves energy and a lot of time that would otherwise be wasted on waiting for the water to heat up to the cooking temp. This cooker has a temperature range of 25 Celsius to 99 Celsius. With its high-precision technology, even a 1 degree difference is noticed by the cooker. Pumping 8 liters of water per minute, this cooker has a pump speed of 1 GMP. Since it comes with a tank, you do not have to invest in your own. The capacity for this tank is 15 to 19 liters which is more than enough for a middle sized family. The Anova makes cooking even more fun for you as it comes with an in-app control feature. You can control and program the device using the app. Just select any recipe from the app and the settings on your cooker will get programmed according to the requirements of that recipe. There is no need to worry even if you are new to sous vide cooking. This is because the Anova comes with an app that has over a 1000 recipes. These sous vide recipes have been formulated and tested by top chefs from around the world. When you start cooking with the Anova Precision cooker, you get cook notifications. This is really helpful for people who need to multi task. You can keep yourself busy with other work while the cooker keeps you notified about the progress of your food. The app has a user-friendly interface, letting you share recipes with your friends. So the next time your guests ask you what recipe you use for your top notch steak, you can share it with them too. Also, there are numerous video tutorials on the app to teach you sous vide cooking. The step by step instructions make cooking so much easier even for beginner level home cooks. The different Anova cookers range from $99 to $150. You can go for the Nano version or the bigger sizes, depending on your needs. It has a rating of 4.3 on Amazon, which means it has satisfied many customers. The Joule Sous Vide cooker is another sous vide machine that is popular among customers. It features a minimalist yet highly elegant design staring with its stainless steel body. The cap and base are both made with stainless steel which makes cleaning very easy. Also, the cold-forged body is resistant to corrosion and will last the test of time because of its durability. As compared to some other immersion circulators, this one is smaller in size which makes it easy to store. Just keep it in the knife compartment or the silverware drawer to save space. The supporting app of this cooker is next-level in its features and ease of use. It has a Visual Doneness feature which lets you see how your food will turn out. This lets you see the final results even before you start cooking. The app also has about a 100 cooking guides that will help you excel at sous vide. These recipes have been devised by the in-house chefs at Chef Steps. Just like the Anova Precision Cooker, this one also has connectivity features. You can connect your phone to the cooker via Wi-Fi or Bluetooth. This makes it really easy to control the settings and check on the doneness of the food even when you are not in the kitchen. Since the immersion circulator comes with a magnetic base, it can be attached anywhere easily. The versatile clip makes it compatible to any pot you have in the house. The Joule Sous Vide immersion circulator is way faster than your everyday circulators out there. It has a wattage of 1100 Watts which heats up water in a matter of seconds while cooking your food at a fast pace too. The settings are easy to program and the temperature settings are precise up to 0.1 F or Celsius. If you have Amazon Alexa at home, then you are in luck because the immersion circulator can also be controlled with your voice because of its Alexa skill. Weighing only 1.3 pounds, this immersion circulator might just be the lightest one in the market. Do not let the size or weight fool you because the strength of this device is matchless in terms of wattage and precision. It is available on Amazon for $199 and has a rating of 4.2 The Sansaire Sous Vide immersion circulator has a smart clip which can be hooked to any heat-resistant pot. Just do that and you are ready to start cooking. The 1000 Watt motor heats the water quickly and propels it so that your food does not stay undercooked. Plus, the 360 circulation feature of this immersion circulator has got you covered ensuring that the water bath stays at a consistent temperature. There won’t be any uneven hot/cold spots in the water bath and your food gets exposed to even temperatures during the entire cooking process. The Sansaire sous vide immersion circulator works with a maximum volume of up to 6 gallons so you can easily feed a party of 8. Weighing 5.9 lbs., this immersion circulator is slightly heavier than other ones on our list. Still, it saves you the cost of expensive vacuum sealing bags as it works just fine with any zip lock or food-grade freeze bag that you may have at home. The LED screen lets you read the temperature and time settings in any light all the way from the kitchen door. The manufacturers have equipped this device with the latest and most innovative thermometer which keeps the temperature in 0.1 degrees of the desired temperature for cooking a meal. This is why the Sansaire immersion circulator is extremely precise, giving you best results every single time. It is a model that is most suitable for cooks who want to keep their cooking simple. Unlike the Anova and Joule immersion circulators, the Sanasire does not have connectivity features. However, that does not take anything away from its performance as an exceptional sous vide device. From salmon fillets to soft-boiled eggs, you can cook everything with this cooker. Made with stainless steel, the cooker will last you a long time since it is corrosion resistant. The body material is also very easy to clean. Just wipe with a damp cloth and you

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a transferor is absolved of liability when a prior owner altered an odometer, but not where a third party altered an odometer, even though in either scenario the act took place during the transferor’s ownership. Id. We disagree. {¶ 36} As noted above, the rule is that “the intent of the law-makers is to be sought first of all in the language employed, and if the words be free from ambiguity and doubt, and express plainly, clearly and distinctly, the sense of the law-making body, there is no occasion to resort to other means of interpretation.” Slingluff v. Weaver, 66 Ohio St. 621, 64 N.E. 574, at paragraph two of the syllabus. The language employed in the previous-owner exception is plain and unambiguous. There is no temporal requirement for a transferor to qualify for the previous-owner exception. Such a requirement plainly does not exist in the statute. Therefore, there is no occasion for the court to resort to other means of 9 SUPREME COURT OF OHIO interpretation. This court would invade the province of the legislature and violate separation of powers if it rewrote the statute to include a requirement that the previous owner be the owner of the vehicle at the time of the odometer tampering. See Arbino v. Johnson & Johnson, 116 Ohio St.3d 468, 2007-Ohio-6948, 880 N.E.2d 420, ¶ 21. This court will not engage in such a practice and leaves it to the General Assembly to rewrite the statute if it deems it necessary. {¶ 37} We therefore hold that the previous-owner exception found in R.C. 4549.46(A) applies to a transferor regardless of when a previous owner tampered with the odometer. Conclusion {¶ 38} For the foregoing reasons, we hold that R.C. 4549.46(A) incorporates the odometer disclosure requirements set forth in R.C. 4505.06 and is not a strict-liability statute. Liability can be imposed only if it is established that the defendant knowingly violated the statute. {¶ 39} We further hold that the previous-owner exception found in R.C. 4549.46(A) applies to a transferor regardless of when a previous owner tampered with the odometer. {¶ 40} Accordingly, we reverse the judgment of the court of appeals and remand this matter to the trial court for further proceedings consistent with this court’s opinion. Judgment reversed and cause remanded. MOYER, C.J., and PFEIFER, LUNDBERG STRATTON, O’DONNELL, LANZINGER, and CUPP, JJ., concur. __________________ Richard Cordray, Attorney General, Benjamin C. Mizer, Solicitor General, Stephen P. Carney, Deputy Solicitor, and David M. Dembinski and Teresa A. Heffernan, Assistant Attorneys General, for appellee. 10 January Term, 2009 Carpenter, Lipps & Leland, L.L.P., Michael H. Carpenter, Jeffrey A. Lipps, and Angela M. Paul Whitfield, for appellant. Dreher Tomkies Scheiderer, L.L.P., Darrell L. Dreher, and Vanessa A. Nelson, urging reversal for amici curiae American Financial Services Association and Association of Consumer Vehicle Lessors, National Automobile Dealers Association, and Ohio Automobile Dealers Association. ______________________ 11 Rough Passages: A Guest Post by K.M. Herkes Ever wanted to know more about the first time superpowers appeared in my Rough Passages world? Now’s your chance. Read on… Why is it a reblog? Because Em Ray invited me to take over her blog one day this week. How could I refuse? I love the fascinating and action-packed Rothganar stories (and adore the lovely background tidbits that get posted on Menyoral.com.) So I jumped at the chance to write a guest post. And when I finished writing this one, I thought, “Wow, this world-building stuff was was fun! And useful too!” So I’ve continued doing more posts like it here on dawnrigger.com, and I carried this first inspiration home today. Enjoy! Please welcome the second of my guests, K.M. Herkes, to talk about the world in her Rough Passages stories. 🙂 ~*~ I read the instructions as, “Talk about one of your worlds and worldbuilding. Anything you want to share.” Here’s what came out. Some worlds begin in stardust. They burst forth from a writer’s imagination in a glimmer of dreams and a sparkle of imagination. Mine? Mine start as raw ore, get hammered into shape through force of will and tempered in my sweat. The world of my Rough Passages Tales started with the following raw materials: the angry sound of a slammed door, a photograph of a smoking handprint, and the thought, “Damned hot flashes. I am going to burst into flames, I swear.” The final shining result? A world where a mid-life crisis can cause natural disasters. I twisted history one tiny bit and traced the ripples of consequence forward to a present day…On Sat, 2006-01-07 at 22:09 -0800, Michael A. Peters wrote: > If I were modifying Fedora for desktop users I've been a devoted Fedora/Red Hat user since Red Hat 5.2 because I've found it to be the most mature and well thought out distribution for desktop use. (Well, at least since RH 7.0...) My servers run Debian. Attachment: signature.ascDescription: This is a digitally signed message partQ: Move from MIT license to a new one I want to move from MIT license to a new one, with this goals to reach: Leave the project free to use for individuals and small open source companies Let commercial companies pay some money for using my software And I have some questions about this plan: What license type should I choose? What kind of monetization strategy for commercial use should I choose? One time for company with unlimited use? Each time company uses software in its projects? Will the license have power only for new versions of the software? Or for the old versions too? A: When you are looking for a license which forces some people to pay you but not others, you aren't looking for an open source license. The open source definition says: No Discrimination Against Persons or Groups The license must not discriminate against any person or group of persons. No Discrimination Against Fields of Endeavor The license must not restrict anyone from making use of the program in a specific field of endeavor. For example, it may not restrict the program from being used in a business, or from being used for genetic research. That means we can not help you to find a license which does this, because that would be off-topic on this website. But there might be a way to reach the goal you want while still keeping the project open source: dual licensing. This is a business model used by many open source companies. Offer the software under two different licenses: Gratis under a copyleft license like the GPL For money under a proprietary license In theory, both license models are available to anyone. But the commercial deal should include some additional perks which are important for large companies but secondary for private people and small businesses, like: A support contract A warranty Additional components which are not GPL and help to integrate the software in a business IT infrastructure. Permission to use the software in closed-source applications The exact details of the deal (like pricing structure and whether to charge by use, by user, by cpu or whatever) are a business decision we can not really help you with unless we know your product and your market. Look at your potential customers and ask yourself what kind of deal would be acceptable when you were in their shoes. Also look at competing products and try to offer a slightly better deal than them. Regarding your question about older versions: The older versions are out there under the MIT license. The MIT license has no revocation clause. That means the old versions stay out there under MIT and can still be changed and redistributed. There is not much you can do about it. But you will have a great competitive advantage against them: MIT licensed code can be integrated into GPL projects, but not the other way around. That means when anyone adds any new features or bugfixes to the old MIT version, you can take them and integrate them into the GPL version. But the GPL does not allow the opposite, so they can not integrate your updates into their version (unless they also switch to the GPL). If you've ever prayed to God for protection then don't bother. Visit All Hallows by the Tower and witness the destruction that he's rained upon it over the last five hundred years. This church has been wrecked more times than me. The first one dated back to 675 AD, but really came

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this matters, and we are prepared to affirm its fundamental character. 3. We said at the outset that there was an excess of the One-substance over the one-predicate, and that this is what partly prevented us from assimilating the One to science for example. Consequently such a substitution has not been carried out; it has only resulted occasionally from the nature of certain Hypotheses. The danger resided in the concept of unity, which, as a super-eminent essence, risked receiving properties due more to Platonist metaphysics' **[72]** valorization of essences than to their reduction to the simplest logical expression. We would thus have harvested, along with the wheat of the One, the One as pure formal term, the chaff of the One as value. This danger must be dissipated. To be sure, each Hypothesis secreted several metaphysical excesses over the amount of logic that it contained, relative to those axioms that we used to frame the beginning of its formulation. But if we take account of the integral and circular character of the matrix, we can consider each excess as due only to the fact that in each Hypothesis, the One can retain or foretell the properties that it receives in another. Step by step, then, the axiomatic matrix as a whole will have reabsorbed the excesses of each particular axiomatic. At bottom, in a given Hypothesis, the One-substance only exceeds the one-predicate by the possible number of predicates it is capable of receiving in all the others. Oddly enough, the dialectical exercise in the _Parmenides_ might reduce [ _réduirait_ ] the essentialist metaphysics by making it circulate in the matrix (whereas in the dialogues without matrix, the ethical or political dialogues, Essence retains on the contrary the splendours and privileges of its solitary valorization). The excess of sense is thereby referred to its true cause, the equivocity of the One due to its distribution across opposed Hypotheses. The One is only substance because it is the support common to all predicates, contradictory or not, that the matrix distributes across it. We will add moreover that Plato mostly limits in each Hypothesis the risks of excess and limits his attention to the case in hand. 4. The result is that in order to manifest this distributive circulation we had to reduce the One to its signifier alone, i.e. to introduce the plane of language. This is to restate here with regard to the general dialectic what was verifiable in each Hypothesis wherever we introduced this plane (with the distinctions that it involves: language-metalanguage, and the ontology it implies: being and the existence of non-real objects), without which the game [ _jeu_ ] of the Hypotheses would have been unplayable. The introduction of language is necessary in order _to save truth through the sacrifice of the thinkable_ , which is the sole duty of the logician. 5. The consideration of these aspects or planes [ _plans_ ] can resolve a last difficulty, one that might arise from interrogating the status of 'our own discourse'. Our self-examination might proceed as follows: To use a matrix of epistemologies is already to prejudge epistemology itself. To which we would respond: no doubt, but in which place of the matrix is this presupposition located? One can refuse the question, and so on to infinity, but it is already useful to know that we can arrange the exercise of the matrix in any of its various cases by a process of _metonymization_ that amounts to substituting, for the language used, the plane of its metalanguage – or again, to replace in the whole of the preceding discussion 'science' by 'epistemology', and 'epistemology' by the matrix exercise itself. And so whoever claims that to refer to a matrix of epistemologies is the mark of a flagrant scepticism will have done nothing more than reposition this exercise as part of Hypothesis VIII. **[73]** We will thus obtain, by generalizing from this discussion, the following dialectics of epistemologies (we have grouped the Hypotheses in pairs): Hyp. I–V The absolute One = One sole epistemology is true, but which one? Impossible to know (absolute idealism). Hyp. II–IV The participated One = One sole epistemology is true, that which communicates to others by division (dogmatism of participation). Hyp. VI–VIII The participated Non-One = All epistemologies are true, none are privileged (relative scepticism). Hyp. VII–IX The absolute Non-One = None are true (absolute scepticism). And finally Hypothesis III, the mediation of all the others, will be no more than the name of the matrix exercise itself. One will thus choose one's place in the matrix and one will be quite glad (or surprised) to discover neighbours that perhaps one did not know – one's neighbours, which is often to say, one's destiny. But one cannot leave the table. The only bad players are to be found among those who have already been dealt their cards. * * * 1 TN: First published as François Regnault, 'Dialectique d'épistémologies', CpA 9.4 (summer 1968): 45–73. Translated by Knox Peden and Peter Hallward. We should draw attention to some of our translation choices here. Although 'meaning' would often be the more natural translation for _sens_ , we generally translate it as 'sense', in order to serve as a reminder of the double meaning (frequently evoked here) of the French term, as both meaning or signification and as direction or orientation. For the sake of consistency, we have translated all instances of _Un_ or _un_ as 'one' (or occasionally 'oneness'), and all instances of _être_ as 'being'. French allows for the distinction between the infinitive _être_ and the participle _étant_ : the first normally translates as 'being as such' (or as to be), the second as being in the sense of 'a being', or as existing; where necessary we will include _étant_ in brackets. We have translated most of Regnault's references to Plato's _Parmenides_ from the French version he usually refers to (Auguste Diès' edition of Plato, _Parménide_ [Paris: Les Belles Lettres], 1923), but where he refers directly to F.M. Cornford's translation we have followed suit (Francis MacDonald Cornford, _Plato and Parmenides_ [London: Routledge & Kegan Paul, 1939]). We have also drawn on Mary Louise Gill and Paul Ryan's translation of _Plato: Parmenides_ (Indianapolis: Hackett, 1996). Wherever one or both of these translations is used it will be signalled in the notes. 2 The reader can easily skip over the preliminaries that follow and pass directly to the application of the Hypotheses. 3 Jean Cavaillès, _Sur la logique et la théorie de la science_ (Paris: PUF, 1946), 27–28. 4 TN: Cornford, _Plato and Parmenides_ , 104–105. 5 TN: Ibid., 108. 6 TN: The French reads ' _il est impossible de rien penser, si l'on ne pense rien d'un._ ' 7 Aristotle, _Metaphysics_ , book IV, 1001a (citing Jules Tricot's translation of Aristotle, _La Métaphysique_ [Paris: Vrin, 1933/1962], II, 156). TN: W.D. Ross' English translation of this passage (in _The Complete Works Of Aristotle: The Revised Oxford Translation_ , vol. 2, ed. Jonathan Barnes [Princeton: Princeton University Press, 1984]) reads: 'If we do not suppose unity and being to be substances, it follows that none of the other universals is a substance; for these are most universal of all. If there is no unity-itself or being-itself, there will scarcely be in any other case anything apart from what are called the individuals.' 8 On this formalism, see Cornford, _Plato and Parmenides_ , 111ff. 9 Ibid., 112. 10 TN: 'VISITOR: Then let's divide them limb by limb, like a sacrificial animal, since we can't do it into two. For we must always cut into the nearest number so far as we can' (Plato, _Statesman_ , 287 _c_ , trans. C.J. Rowe, in Plato, _Complete Works_ ). 11 This point has been established by Victor Goldschmidt, _Les Dialogues de Platon_ (Paris: PUF, 1947); see in particular sections 1, 6, and 13–16. See also, for Plato's _Meno_ , Alexandre Koyré, _Introduction à la lecture de Platon_ [1945] (Paris: Gallimard, 1962). 12 Cornford, _Plato and Parmenides_ , 111. 13 TN: Laplanche and Pontalis present the Freudian concept of _Triebentmischung_ in French as _désintrication_ or _désunion_ and in English as 'def

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._load_form_data() return self.form @cached_property def values(self): """Combined multi dict for :attr:`args` and :attr:`form`.""" args = [] for d in self.args, self.form: if not isinstance(d, MultiDict): d = MultiDict(d) args.append(d) return CombinedMultiDict(args) @cached_property def files(self): """:class:`~werkzeug.datastructures.MultiDict` object containing all uploaded files. Each key in :attr:`files` is the name from the ``<input type="file" name="">``. Each value in :attr:`files` is a Werkzeug :class:`~werkzeug.datastructures.FileStorage` object. Note that :attr:`files` will only contain data if the request method was POST, PUT or PATCH and the ``<form>`` that posted to the request had ``enctype="multipart/form-data"``. It will be empty otherwise. See the :class:`~werkzeug.datastructures.MultiDict` / :class:`~werkzeug.datastructures.FileStorage` documentation for more details about the used data structure. """ self._load_form_data() return self.files @cached_property def cookies(self): """Read only access to the retrieved cookie values as dictionary.""" return parse_cookie(self.environ, self.charset, cls=self.dict_storage_class) @cached_property def headers(self): """The headers from the WSGI environ as immutable :class:`~werkzeug.datastructures.EnvironHeaders`. """ return EnvironHeaders(self.environ) @cached_property def path(self): """Requested path as unicode. This works a bit like the regular path info in the WSGI environment but will always include a leading slash, even if the URL root is accessed. """ path = '/' + (self.environ.get('PATH_INFO') or '').lstrip('/') return _decode_unicode(path, self.url_charset, self.encoding_errors) @cached_property def script_root(self): """The root path of the script without the trailing slash.""" path = (self.environ.get('SCRIPT_NAME') or '').rstrip('/') return _decode_unicode(path, self.url_charset, self.encoding_errors) @cached_property def url(self): """The reconstructed current URL""" return get_current_url(self.environ) @cached_property def base_url(self): """Like :attr:`url` but without the querystring""" return get_current_url(self.environ, strip_querystring=True) @cached_property def url_root(self): """The full URL root (with hostname), this is the application root.""" return get_current_url(self.environ, True) @cached_property def host_url(self): """Just the host with scheme.""" return get_current_url(self.environ, host_only=True) @cached_property def host(self): """Just the host including the port if available.""" return get_host(self.environ) query_string = environ_property('QUERY_STRING', '', read_only=True, doc= '''The URL parameters as raw bytestring.''') method = environ_property('REQUEST_METHOD', 'GET', read_only=True, doc= '''The transmission method. (For example ``'GET'`` or ``'POST'``).''') @cached_property def access_route(self): """If a forwarded header exists this is a list of all ip addresses from the client ip to the last proxy server. """ if 'HTTP_X_FORWARDED_FOR' in self.environ: addr = self.environ['HTTP_X_FORWARDED_FOR'].split(',') return self.list_storage_class([x.strip() for x in addr]) elif 'REMOTE_ADDR' in self.environ: return self.list_storage_class([self.environ['REMOTE_ADDR']]) return self.list_storage_class() @property def remote_addr(self): """The remote address of the client.""" return self.environ.get('REMOTE_ADDR') remote_user = environ_property('REMOTE_USER', doc=''' If the server supports user authentication, and the script is protected, this attribute contains the username the user has authenticated as.''') scheme = environ_property('wsgi.url_scheme', doc=''' URL scheme (http or https). .. versionadded:: 0.7''') is_xhr = property(lambda x: x.environ.get('HTTP_X_REQUESTED_WITH', '') .lower() == 'xmlhttprequest', doc=''' True if the request was triggered via a JavaScript XMLHttpRequest. This only works with libraries that support the `X-Requested-With` header and set it to "XMLHttpRequest". Libraries that do that are prototype, jQuery and Mochikit and probably some more.''') is_secure = property(lambda x: x.environ['wsgi.url_scheme'] == 'https', doc='`True` if the request is secure.') is_multithread = environ_property('wsgi.multithread', doc=''' boolean that is `True` if the application is served by a multithreaded WSGI server.''') is_multiprocess = environ_property('wsgi.multiprocess', doc=''' boolean that is `True` if the application is served by a WSGI server that spawns multiple processes.''') is_run_once = environ_property('wsgi.run_once', doc=''' boolean that is `True` if the application will be executed only once in a process lifetime. This is the case for CGI for example, but it's not guaranteed that the exeuction only happens one time.''') class BaseResponse(object): """Base response class. The most important fact about a response object is that it's a regular WSGI application. It's initialized with a couple of response parameters (headers, body, status code etc.) and will start a valid WSGI response when called with the environ and start response callable. Because it's a WSGI application itself processing usually ends before the actual response is sent to the server. This helps debugging systems because they can catch all the exceptions before responses are started. Here a small example WSGI application that takes advantage of the response objects:: from werkzeug.wrappers import BaseResponse as Response def index(): return Response('Index page') def application(environ, start_response): path = environ.get('PATH_INFO') or '/' if path == '/': response = index() else: response = Response('Not Found', status=404) return response(environ, start_response) Like :class:`BaseRequest` which object is lacking a lot of functionality implemented in mixins. This gives you a better control about the actual API of your response objects, so you can create subclasses and add custom functionality. A full featured response object is available as :class:`Response` which implements a couple of useful mixins. To enforce a new type of already existing responses you can use the :meth:`force_type` method. This is useful if you're working with different subclasses of response objects and you want to post process them with a know interface. Per default the request object will assume all the text data is `utf-8` encoded. Please refer to `the unicode chapter <unicode.txt>`_ for more details about customizing the behavior. Response can be any kind of iterable or string. If it's a string it's considered being an iterable with one item which is the string passed. Headers can be a list of tuples or a :class:`~werkzeug.datastructures.Headers` object. Special

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of "grossly mismanaging the storing, handling, and processing of the complainant's reprisal file." In December 2010, the auditor general criticized Dion's predecessor, Christiane Ouimet, who was found to have retaliated against employees and generally acted inappropriately while in office. David Hutton, executive director of Federal Accountability Initiative for Reform, said Tuesday that Dion "has too much discretion" in the handling of complaints, and "he always uses his discretion to protect the government." Hutton said FAIR was kicked out of the integrity commissioner's advisory board for publicly criticizing the office. He said FAIR is in contact with 50 government whistleblowers, many of whom Hutton said have had negative experiences with Dion's office. Edith Lachapelle, spokeswoman for the integrity office, said the misconduct described in the auditor general's report "is almost impossible to happen again." Lachapelle said the problems with the two files started at the beginning of Dion's mandate and the office has "covered all the bases to assure that these isolated incidents do not happen again."# # Copyright 2020-present Facebook. All Rights Reserved. # # This program file is free software; you can redistribute it and/or modify it # under the terms of the GNU General Public License as published by the # Free Software Foundation; version 2 of the License. # # This program is distributed in the hope that it will be useful, but WITHOUT # ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or # FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License # for more details. # # You should have received a copy of the GNU General Public License # along with this program in a file named COPYING; if not, write to the # Free Software Foundation, Inc., # 51 Franklin Street, Fifth Floor, # Boston, MA 02110-1301 USA # FILESEXTRAPATHS_prepend := "${THISDIR}/files:" SRC_URI += " file://setup-ipmbd.sh \ file://run-ipmbd_0.sh \ file://run-ipmbd_4.sh \ " do_install() { dst="${D}/usr/local/fbpackages/${pkgdir}" bin="${D}/usr/local/bin" install -d $dst install -d $bin install -m 755 ipmbd ${dst}/ipmbd ln -snf ../fbpackages/${pkgdir}/ipmbd ${bin}/ipmbd install -d ${D}${sysconfdir}/init.d install -d ${D}${sysconfdir}/rcS.d install -d ${D}${sysconfdir}/sv install -d ${D}${sysconfdir}/sv/ipmbd_0 install -d ${D}${sysconfdir}/ipmbd_0 install -d ${D}${sysconfdir}/sv/ipmbd_4 install -d ${D}${sysconfdir}/ipmbd_4 install -m 755 setup-ipmbd.sh ${D}${sysconfdir}/init.d/setup-ipmbd.sh install -m 755 run-ipmbd_0.sh ${D}${sysconfdir}/sv/ipmbd_0/run install -m 755 run-ipmbd_4.sh ${D}${sysconfdir}/sv/ipmbd_4/run update-rc.d -r ${D} setup-ipmbd.sh start 65 5 . } FBPACKAGEDIR = "${prefix}/local/fbpackages" FILES_${PN} = "${FBPACKAGEDIR}/ipmbd ${prefix}/local/bin ${sysconfdir} " INHIBIT_PACKAGE_DEBUG_SPLIT = "1" INHIBIT_PACKAGE_STRIP = "1" When using relatively generic search terms like "web" or "SMS" in the iOS App Store, users now receive inline "advertisements" for Apple's built-in equivalents before any third-party apps are shown. Each placard is the same size as a normal app page, but features a different design with fewer elements— the app's icon, a small market blurb about its features, and a direct link to the app or to Apple's website. The interstitials were first noticed by MacStories. A search for "web," for instance, returns Safari's familiar compass logo with accompanying text that prods the reader to "see the web the way it was meant to be seen" and a button that switches to Apple's browser. Using the term "SMS" shows a similar format, but swaps the application button for a "Learn More" link to the Messages marketing page on Apple.com. As noted by MacStories, this is not the first time Apple has manually altered results for specific search terms. Searching for "maps" still brings a link to a listing of alternatives to Apple's built-in navigational aide that was first introduced after the disastrous release of Apple Maps in iOS 6. The App Store search and ranking system is often criticized by developers, and Cupertino's latest move will likely add fuel to that long-burning fire. The company has made several efforts to improve discoverability in the store, most notably acquiring cross-platform app indexing startup Chomp in 2012.Cartoonist Bill Ansell had a heart transplant at Harefield Hospital in 1991. Shortly after his treadmill/exercise test he drew this cartoon. 10 years on and they still use this technique. Only now we have Ann who has added an extra torture, she I am sure puts her hands in the freezer for 10 minutes before touching any patients, especially me. So what do they do to you? First of all they attach ecg stickers to your chest, then check your pulse and blood pressure, then to make you feel really comfortable and at ease, call for a doctor to attend while the test takes place in case they are needed. Now you step on to the treadmill, the ecg leads are attached to the stickers on your chest, the blood pressure arm band is left on your arm, then a clip is put on your nose, and then you have to put a mouth piece in your mouth so that the amount of oxygen you breathe in, and the amount of carbon dioxide you breathe out during the test can be monitored. Ok your under starters orders and we're off, not to bad at first on the flat at a steady pace. Three minutes on and suddenly were going up hill, still not so bad ecg and blood pressure being taken, Ann then with a big smile asks if you are feeling ok, I am sure she is enjoying every minute. Another three minutes even higher and a little faster, now I am being to feel tired, this thing in my mouth isn't helping, nine minutes done and up a little higher. 9 minutes 47 seconds and my calf muscles have had enough and the test is stopped, now Ann is almost laughing she I can tell really does enjoy this part of her job. Apparently I didn't do to bad, Ann then tells me I won't have to do this test again, then just as I begin to relax and smile, she adds with the mouth piece. She really is evil, but for some reason I still like her. I may even buy her a Christmas present (a pair of woolen gloves).# [![angular-translate](https://raw.github.com/angular-translate/angular-translate/canary/identity/logo/angular-translate-alternative/angular-translate_alternative_medium2.png)](http://angular-translate.github.io) [![Greenkeeper badge](https://badges.greenkeeper.io/angular-translate/angular-translate.svg)](https://greenkeeper.io/) ![Bower](https://img.shields.io/bower/v/angular-translate.svg) [![NPM](https://img.shields.io/npm/v/angular-translate.svg)](https://www.npmjs.com/package/angular-translate) [![cdnjs](https://img.shields.io/cdnjs/v/angular-translate.svg)](https://cdnjs.com/libraries/angular-translate) [![Build Status](https://img.shields.io/travis/angular-translate/angular-translate.svg)](https://travis-ci.org/angular-translate/angular-translate) ![License](https://img.shields.io/npm/l/angular-translate.svg) ![Code Climate](https://img.shields.io/codeclimate/github/angular-translate/angular-translate.svg) ![Code Coverage](https://img.shields.io/codeclimate/coverage/github/angular-translate/angular-translate.svg) This is the repository for angular-translate. angular-translate is a JavaScript translation library for AngularJS 1.x app. For more information about the angular-translate project, please visit our [website](https://angular-translate.github.io). ## Status | Branch | Status | | ------------- |:-------------:

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ICESTRIENSIS. [Another work by this author may be found in some of our public libraries, entitled _Poems on various {132} Subjects and different Occasions, chiefly adapted to Rural Entertainment in the United States of America_. 8vo. 1797. The Preface to this work also gives some account of Searson's residence in Ireland, where, he says, "I lived happily for fifteen years, till another king (or agent) arose, who knew not Joseph, who, in the most inhuman, cruel, and tyrannical manner, made use of his interest to have me put out of my place." The work concludes with the following advertisement respecting himself:--"Being unemployed at present, should any of my kind subscribers know of any vacancy as tutor in some gentleman's family, a place in some public office, genteel compting-house, or vacancy for a schoolmaster, the author will be grateful for the favour of acquainting him of it. He may be heard of by applying to Mr. Mathew Carey, of Market Street, bookseller."] * * * * * Minor Queries. _Haberdon, or Habyrdon._--A manor now belonging to the school at Bury St. Edmund's bears this name. Can any meaning be given to the word? The land formerly belonging to the Abbey of St. Edmund, several registers of that monastery, A.D. 1520 and 1533, let the said manor of Habyrdon, on condition the tenant should yearly find one white bull, &c. The leases all describe this manor of Habyrdon and make it specially necessary to find a white bull. The land is contiguous to the town of Bury, and is called Haberdon at the present time, presents a hilly appearance and remains of ancient intrenchments. I have not heard of any other place by this name. C. G. Paddington. _Holles Family._--I am very desirous of obtaining any information that can be procured concerning the Holles family prior to the time of Sir William, who was Lord Mayor of London in 1540. I should also be obliged if any of your numerous correspondents can inform me, whether that member of the family who married a lady named Gelks, I think since 1700, left any posterity; from whom he was descended, and in what county he lived? Also, who the Gelkses were, and whether the family is represented now; and, if so, of what county they are? The arms of the Holleses were--Ermine, two piles conjoining in the points sable. The crest was a boar's head erased, azure, langued gules, pierced with a pheon. The Gelks bore--Ermine, three chevrons azure, charged with nine bezents inter nine annulets gules. M. T. P. Reading. "_To lie at the Catch_" (Vol. vi., p. 56.).--From accidental circumstances I have only lately seen the notice of my Query. Will you excuse my saying that I do not yet understand the meaning of the phrase "To lie at the catch," and that I shall be greatly obliged if you or any of your correspondents will explain it further, or, in other words, give me a paraphrase that will suit the two passages I have quoted. M. D. _Names of Planets--Spade._--Would any of your correspondents give me some information respecting the _names_ of the different planets of our system, whether their titles are coeval with the apotheosis of the various denizens of Olympus whose names they bear; or whether such names were bestowed upon the heavenly bodies at some later date in honour of those divinities? I should also like to hear explained, how the word _spade_, which from its affinities in other languages would appear to have originally meant _sword_, ever came to be transferred from a weapon of war to the useful and harmless implement it now designates. [Greek: Ouden]. _Arms in painted Glass._--The following arms have recently been found in some decorated windows of the early part of the fourteenth century. Information as to whom belonging would be esteemed a favour. 1. Gules, a chevron, or. 2. Quarterly, first and fourth gules, a mullet, or, second and third sable, a cross, or. 3. Argent, on a chevron, or, three bucks' heads caboshed, tincture indistinct, probably sable. QUAERENS. _The Sign of "The Two Chances."_--An inn, at Clun, in this county, bears the unusual sign of "The Two Chances." What can this mean? Mine host is also Registrar of Births and Deaths for the district. Does it refer to _these two chances_? GEORGE S. MASTER. Welsh-Hampton, Salop. _Consecrators of English Bishops._--It may appear a waste of space to insert in your columns my Queries on this subject, but when you consider that I have been an exile in India for the last eleven years, and consequently unable to refer, in this country, to authorities, which are easily accessible at home, I venture to hope that you will not only give a place to this, but also that you, or some clerical reader of "N. & Q.," will afford me the required information. I have continued Mr. Perceval's list of English consecrations, given in his able work, _An Apology for the Doctrine of Apostolical Succession_, 2nd edition of 1841, but have been unable to complete it with the names of the consecrators of the following prelates, the objects of my Query; viz. 1. Bishop Gilbert, of Chichester, on 27th February, 1842; 2. Bishop Field, of Newfoundland, 28th April, 1844; 3, 4, & 5. Bishops Turton of Ely, Medley of Fredericton, and Chapman of {133} Colombo, on 4th May, 1845; 6. Bishop Gobat, 5th July, 1846; 7 & 8. Bishops Smith of Victoria, and Anderson of Rupert's Land, on 29th May, 1849; 9. Bishop Fulford of Montreal, 25th July, 1850; and 10. Bishop Harding of Bombay, on 12th August, 1851. The dates are, I believe, correct, but if not, of course I should like the mistakes to be pointed out. I also desiderate the date of Bishop Binney's (of Nova Scotia) consecration, in March or April, 1851, with names of his consecrators; and finally, the place of Bishop Lonsdale's (of Lichfield) consecration, on 3rd December, 1843. If these data are supplied, the lacunae in my supplemental list of English consecrations, from the Reformation to the present day, will be complete. A. S. A. Punjaub. _A nunting Table._--What is it? The word occurs in a quotation from Dr. Newman in the _Irish Ecclesiastical Journal_ for December, 1852, describing a modern English church. I suppose I shall be snubbed for not giving the passage; but my copy of the journal has vanished. A. A. D. _John Pictones._--Is anything known of John Pictones, or Pyctones, a person mentioned in a MS. as having taught languages to Queen Elizabeth when she was young? C. R. M. _Gospel Place._--In a definition of the boundaries of Bordesley Abbey, dated 1645, given in Nash's _Worcestershire_, there frequently occurs the term "Gospel place," thus: "And so to a Cross or Gospel Place near to Brown's cottage, and from thence to a Gospel Place under a tree near to a mill ... thence to the old Gospel Place oak that standeth on the common." I have heard that at each one of these "Gospel places" there was kept up a mound on which it was usual to rest a corpse on its way to the churchyard, during which time some portion of the gospel was read. Can any of your correspondents say if such a practice was observed in any other part of the country, its origin, its intention, and the period of its discontinuance? And if not, can give any other explanation of the term? G. R. _York Mint._--Can any of your correspondents inform me of the names of the officers

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devoted an entire treatise – _Creation and Its Mysteries Revealed_ – to showing how the continents had once been united. But in the mid-nineteenth century there was simply no context for such a radical overhaul of geological theory; no other pieces of knowledge with which the theory itself could fit. A mainstay of nineteenth-century geology was a belief in the existence of enormous land-bridges which had at one point joined the world's continents, but had since then crumbled into the oceans. These land-bridges explained the existence of the same species on different landmasses, and seemed far more plausible than mobile continents. In 1912, therefore, Wegener was arguing against the grain of prevailing wisdom: if his theory were correct, it would nullify many of the founding assumptions of nineteenth-century geology. Worse still, Wegener was an intruder, a trespasser on the turf of the geologists. For his main field of research was meteorology – he was a pioneer in weather-balloon study and a specialist in Greenland, where he led several successful, and one fatal, Arctic research expeditions. How could a weatherman presume to dismantle at a single stroke the complex and magnificent edifice of nineteenth-century geology? The opposition to Wegener's theory, as to that of Burnet so many years earlier, was immediate and voluble ('Utter, damned rot!', said the president of the American Philosophical Society, eloquently). But Wegener, a stoic visionary, remained phlegmatic in the face of early antagonism. In 1915 he published _The Origins of Continents and Oceans_ , a careful explanation of his theory, and in its way as apocalyptic a reimagining of the earth's history as Burnet's _The Sacred Theory of the Earth_ or Hutton's _The Theory of the Earth_. Between 1915 and 1929 Wegener revised his _Origin_ three times to take into account advances in geology, but he was still ignored by the geological establishment. In 1930 he led another meteorological expedition to Greenland. Three days after his fiftieth birthday he and his team were caught in a severe Arctic blizzard, in which temperatures dropped to −60°F. Wegener became separated from his companions, and froze to death in the private wilderness of a white-out. His body was found by his colleagues when the storm receded. They entombed Wegener inside a mausoleum built of blocks of ice, topped with a twenty-foot iron cross. Within a year, the structure and its contents had disappeared into the interior of the glacier on which it was built – a means of burial that would no doubt have met with Wegener's approval. It was not until the advent of the so-called New Geology during the 1960s that it was realized that Wegener had been at least half-right. As advances in bathysphere technology permitted the more systematized exploration of the ocean floor, it was discovered that the continents did indeed move and had indeed spun apart from a vast ur-continent. But the continents weren't – as Wegener had thought – independent entities drifting over a sea of basalt, like icebergs in water. In fact, the surface of the globe was discovered to be composed of some twenty crustal segments or plates. The continents were simply the portions of the plates which were sufficiently elevated to protrude from the sea. These plates were named by the New Geologists. There was the African Plate, the Cocos Plate, the North American Plate, the Nazca Plate, the Iran Plate, the Antarctic Plate, the Juan de Fuca Plate, the Australian Plate, the Arabian Plate and the decidedly unfragile China Plates. Driven by convection currents or 'cells' within the semi-liquid mantle of the earth, and pulled by their own weight, these plates move around relative to each other. Where their edges meet beneath the ocean, either a mid-ocean ridge or a subduction zone is formed. At mid-ocean ridges the boundaries of two plates are continually being pushed apart by action in the mantle. Magma rises into the gap, and cools to form sea-floor basalt. Mid-ocean ridges are therefore raised above the surrounding ocean floor, like the seam on a cricket ball. A subduction zone, by contrast, is where the edges of two plates are forced together, and the less buoyant plate slides underneath the other. There, the rock of the subordinate plate is pushed down into the mantle, where it melts and comes bubbling back up in liquid form, causing super-heated wounds in the crust. These subduction zones form the oceanic trenches: the Aleutian Trench, the Java Trench, the Marianas Trench. At the bottom of these trenches – the Marianas Trench is deeper than Mount Everest is high – the atmospheric pressure is so enormous that, were you to materialize at that depth, your body would instantly be compacted to the size of a tin can. Most of the world's mountain ranges have been thrown up by the jostling and collision of the continental plates. Thus, for example, the Alps were created when the Adriatic Plate (which carries Italy on its back) was driven into the Eurasian Plate. The oldest mountains are those which are now the lowest, for erosion has had time to reduce them. The blunted, rubbed-down spine of the Urals, for instance, speaks of great age. So too do the rounded forms of the Scottish Cairngorms. Perhaps surprisingly, among the youngest mountains on earth are the Himalaya, which began to form only 65 million years ago, when the Indian Plate motored northwards and smashed slowly into the Eurasian Plate – ducking underneath it and then butting it five-and-a-half miles upwards into the air. Compared to the earth's venerable ranges, the Himalaya are adolescents, with sharp, punkish ridges instead of the bald and worn-down pates of older ranges. Like adolescents, too, they are still growing. Everest – which became the world's highest mountain less than 200,000 years ago – shoots up by a precocious five millimetres or so a year. Give it a million years – the blink of an eye in geological terms – and the mountain could have almost doubled its height. Except of course that won't happen, because gravity won't tolerate such a structure. Something will give: the mountain will collapse under its own weight, or be shaken apart by one of the huge earthquakes which rack the Himalaya every few centuries. For years now I have gone to the mountains and been astonished by deep time. Once, halfway up the mica-rich peak of Ben Lawers in Scotland on a sunlit day, I found a square chest of sedimentary rock, hinged at its back with an overgrowth of moss and grass. Stepping back and looking at it from the side, I could see it was composed of hundreds of thin layers of grey rock, each one no thicker than a sheet. Each layer, I reckoned, was a paraphrase of 10,000 years – a hundred centuries abbreviated into three millimetres' depth of rock. Between two of the grey layers I noticed a thin silvery stratum. I pushed the adze of my walking axe into the rock, and tried to lever the strata apart. The block cracked open, and I managed to get my fingers beneath the heavy top lid of rock. I lifted, and the rock opened. And there, between two layers of grey rock, was a square yard of silver mica, seething brightly in the sunlight – probably the first sunlight to strike it in millions of years. It was like opening up a chest filled to the brim with silver, like opening a book to find a mirror leafed inside it, or like opening a trapdoor to reveal a vault of time so dizzyingly deep that I might have fallen head-first into it. * Although, as Simon Winchester has recently pointed out, a 1991 poll returned that 100 million Americans believed God to have created man in his own image sometime in the last 10,000 years. The earth is thought by science to be around 5 billion years old; the first humans to have appeared _circa_ 2 million years ago. * Geology remained a driving force in mountaineering until well into the twentieth century – the first three Everest expeditions (1921, 1922 and 1924) were funded in part as scientific expeditions aimed at bringing back geological (and botanical) knowledge of the Everest region. # 3 The Pursuit of Fear That Alpine witchery still onward lures, Upwards, still upwards, till the fatal list Grows longer of the early mourned and missed. FRANCES RIDLEY HAVERGAL, 1884 I looked upwards. A tall, steep face of rock, striped vertically with snow gullies, angled up into the lightening sky. That was our route. My eye followed the face down. Without relenting in angle, it dropped some 600 feet to a small glacier which arced off the bottom of the face. The convex surface of the glacier looked hard, silvered and pitted like old metal, and it was pocked with stones which had fallen from the cliffs above. Further down, the glacier tumbled over a hundred-foot drop. There its surface turned a curdled grey, and the smoothness of the upper ice became ruptured into crevasses and blocks. I could see glimmers of blue ice far down inside the body of the glacier. That was where

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grand jury secrecy. That includes more than 240 redactions from the first volume of the report alone. Howell gave DOJ until Wednesday, Oct. 30, to comply. A Justice Department spokeswoman did not immediately respond to a request for comment. The White House and congressional Republicans have argued that the Democrats' impeachment inquiry, which has expanded to include a probe into whether Trump pressured Ukraine into investigating former Vice President Biden and his son, is illegitimate because it hasn't been authorized by a vote in the House. The DOJ echoed that argument to the district court last month, writing in a filing that “impeachments of Presidents Clinton and Andrew Johnson were investigated in multiple phases with each phase authorized by the House’s adoption of resolutions.” Howell rejected the Justice Department's assertion in her opinion Friday. "Even were this statement accurate, which it is not, the manner in which the House has chosen to conduct impeachment inquiries encompasses more than past Presidents and no sound legal or constitutional reason has been presented to distinguish the House’s exercise of impeachment authority for a President from the exercise of such authority more generally," Howell wrote. The House Judiciary subpoena is part of a legal battle being fought on several fronts between the Trump administration and House Democrats investigating the president. The committee applied for a court order for the grand jury materials in July in order to continue Mueller's probe into Russian interference and possible obstruction of justice by the White House. "Because Department of Justice policies will not allow prosecution of the sitting president, the United States House of Representatives is the only institution of the federal government that can now vote President Trump accountable for these actions,” Rep. Jerrold Nadler Jerrold (Jerry) Lewis NadlerDemocrats shoot down talk of expanding Supreme Court Schumer: 'Nothing is off the table' if GOP moves forward with Ginsburg replacement Top Democrats call for DOJ watchdog to probe Barr over possible 2020 election influence MORE (D-N.Y.), the chairman of the Judiciary Committee, said in a press conference at the time. Nadler said on Friday that he's gratified by the court victory. “The court’s thoughtful ruling recognizes that our impeachment inquiry fully comports with the Constitution and thoroughly rejects the spurious White House claims to the contrary," he said in a statement. "This grand jury information that the Administration has tried to block the House from seeing will be critical to our work.” Trump has also been fighting efforts to obtain his tax returns, other financial records and documents related to his Washington hotel. The president has shown no willingness to compromise on any of the document requests. This week, following an appeals court ruling uphold the House Oversight and Reform Committee's subpoena of the president's accounting firm, Trump's lawyers said they intended to take the case to the Supreme Court. Also this week, in another case that seems destined for the nation's highest court, Trump's personal lawyers doubled down on their assertion that the president is immune from criminal investigation and prosecution while in office — a view that has been endorsed by DOJ. Howell on Friday noted in her opinion that theory of blanket immunity for the president "has never been adopted, sanctioned, or in any way approved by a court." Updated at 5:24 p.m. Order Redacted Mueller Mate... by M Mali on ScribdReuters) - Dutch bioscience company Pantarhei intends to bid for the bulk of U.S. company Merck's (MRK.N) Netherlands-based bioscience research unit Organan, the Dutch Financieele Dagblad reported on Monday.Gavce Gavce (, sometimes misspelled Gavče) is a settlement in the Municipality of Šmartno ob Paki in northern Slovenia. It lies on the left bank of the Paka River north of Šmartno. Traditionally the area was part of the Styria region. The municipality is now included in the Savinja Statistical Region. A small chapel-shrine in the settlement containing a statute of Saint Urban dates to the mid-19th century. References External links Gavce at Geopedia Category:Populated places in the Municipality of Šmartno ob PakiFund seeks to help counties pay bills, fight opioid abuse COLUMBUS >> A veteran Ohio politician called on Wednesday for the creation of a special state fund to help counties boost employment, fight opioid abuse and cover basic expenses. Any of the state’s 88 counties, large or small, would be eligible to draw from the equalization fund proposed Wednesday by Republican Gene Krebs. The former state representative is a farmer and public policy expert from Preble County who’s running for state Senate. Krebs said Ohio originally created county governments to implement the state’s policies and laws, but those without ample retail businesses subject to sales taxes have little way to raise the funds they need in the wake of local government fund cuts. “In short, counties themselves were the original unfunded mandate,” he said. “But due to changes in shopping and lifestyle, many are now unable to fully locally fund their duties.” Advertisement Krebs cited a recent study by the Cleveland-based Center for Community Solutions that found: • 16 percent of working-age adults in small rural towns are disabled, a higher proportion than in big cities or the state as a whole. • 15 percent of those 25 or older in small rural towns hold college degrees, compared to 25 percent in big cities and the state as a whole. • 34 percent of children in small rural towns live in poverty, compared to 23 percent statewide. • 75 percent of school-aged children in small rural towns participate in the federal school lunch program for those below or near poverty, exceeding the statewide rate by more than 25 percent. Krebs said his proposed fund is aimed at beginning to reverse this problem by “equalizing” county revenue based on where residents shop. A county whose residents shop and dine elsewhere would have a greater chance for access to the fund, while a county with a large outlet mall drawing many out-of-county shoppers would have less opportunity. “This is not Robin Hood. We are not proposing to reduce the piggyback sales tax revenue from the rich counties and give to the poor,” he said. “This is also not county welfare. It is meant to help them get back up on their feet.” State funds used to develop the equalization fund could be tapped for one of only three purposes: to combat the opioid and heroin epidemic, for economic development programs that increase sales-tax revenue and workforce development, or to cover general county expenses. The fund is designed to expire after 10 years, with interim assessments built in to see how the plan is doing. Krebs said the state Department of Taxation would prepare new charts annually for disbursement of the money and the fund would be subject to regular state audits.In some cases, pirates get away with the act by exploiting how stores like Amazon manage inventory. They'll let third parties lump their stock in with those of official partners (right down to similar barcodes), making it relatively easy to slip bogus products through the cracks. The RIAA says Amazon was eager to help tackle pirated material after learning of the findings, and Amazon itself says it's "working closely" with both distributors and labels to clamp down on counterfeiters. There's certainly some urgency to improve anti-piracy efforts. Although downloads and streaming thrive in North America, CDs make up just shy of 40 percent of worldwide music industry revenue. Publishers can't count on digital sources to pick up all the financial slack, especially in regions where CDs are either relatively popular (such as Europe) or the only realistic way to listen. Until broadband is both ubiquitous and genuinely affordable for a large chunk of the world, CD piracy is bound to be tempting.The Shirt A basic Latin/Rhythm shirt is usually a long sleeved black or white shirt without patterning or reflective materials. Shirts are often opened to mid-chest or lower, or turtle necked. These shirts aren't really shirts, but leotards. They strap around between the legs, or have built in shorts, so that the shirt doesn't become untucked while dancing. You can always wear a regular dress shirt, but it is likely to become untucked during dancing, and the shoulders will often look scrunched up, distorting your frame. If you don't want to spend the money, you can wear an Under Armour shirt instead, since Latin shirts are expensive. Most shirts cost around $150, but high end custom made shirts can cost as much as $400. Latin/Rhythm pants are solid black pants, sometimes with a satin stripe down the outside of the leg or a satin waistline. They differ from Standard/Smooth pants in that they are tighter at the thighs, but flare out to be wider at the lower legs. They also usually have a sewed in seem down the front to make them look recently ironed. Sometimes they have an elastic band that wraps around the foot so the pants don't slide up and expose the leg during dancing. There is no difference between the pants generally worn by beginners and those worn by advanced dancers. Latin pants start out at around $80 and can cost as much as $400 for a high end custom made pair. Basic Standard/Smooth Shirt Most beginners don't want to spend thousands of dollars on a tail suit, and many prefer a basic Standard shirt. If you aren't wearing tails, you must wear a white dress shirt. It can have any kind of collar and cuffs, but it must be

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, and the extent of Palestinian frustration. The latter could be more fueled by a Palestinian retreat from U.N. action and a return to meaningless negotiations or by a failure at the U.N. to overwhelmingly endorse Palestinian rights than by a successful, symbolic win at the U.N., even if that does not translate the morning after into new freedoms on the ground. Having said all of this, there are ways in which a U.N. resolution could be constructive and help achieve progress toward a better future for both Palestinians and Israelis (of course these prospects will partly depend on the exact wording and nature of any specific resolution). For instance, a U.N. resolution clarifying that a two-state solution would be on the 1967 lines (allowing for modifications to that line only on the basis of agreed, equal, and minor land exchanges) with Jerusalem serving as the capital of both states, could help ground any future negotiations in more realistic terms, establishing that the contours of a two-state arrangement cannot be endlessly flexible while also undermining the time-wasting and obfuscatory special pleading that tends to characterize Israeli negotiation tactics. At the same time, such a resolution would powerfully entrench the two-state solution, guaranteeing a future for both Israel and a Palestinian state. That is the main reason that those preferring a one-state outcome -- from both the more absolutist Palestinian rights camp and from the Greater Israel settler camp -- are opposed to this U.N. move. This should provide a reason for the pro-democracy wing of the pro-Israel camp to attempt to work constructively in this U.N. space. Yet most of the American Jewish establishment groups who by self-definition claim to support a democratic Israel seem more busy taking a victory lap every time another Eastern European or Pacific Island state declares itself against the U.N. vote. In Israeli domestic political terms a strongly endorsed U.N. resolution would administer a kick to the groin of the peace rejectionist policies pursued by the current Netanyahu-Lieberman government. It is hard to see how peace is advanced by rewarding those rejectionist policies, whether at the U.N. or in the constructing of Quartet statement language. For the Palestinians, a U.N. resolution that upgrades their U.N. status to non-member state (similar to the Vatican status), would pave the way to membership in additional institutions including very likely the ability to take cases to the International Criminal Court (ICC). While the asymmetry of Israeli-Palestinian realities and therefore the logic of the Palestinians gaining leverage by utilizing non-violent diplomatic tools of this nature is a powerful one, this is not something that the Palestinian leadership is claiming it will pursue subsequent to any U.N. vote. Given both the legitimacy of the U.N. as a venue for advancing Israeli-Palestinian conflict resolution and this non-exhaustive list of potential benefits that could be derived from such a move, why is it that the U.S. (and in many ways Europe) are so uncomfortable about a U.N. vote and working so hard to prevent it from occurring? The respective reasons for American and European opposition are not exactly the same. Both share a preference to be on the same page when it comes to this issue and it is unlikely that would happen should it come to a U.N. vote. When the Security Council voted on a settlements resolution in February, the EU states supported the resolution while the U.S. was alone in opposing and vetoing it. The U.S. and Europe also share a concern that the U.N. route would signal the beginning of them losing control of this issue (a worry that is more acute for the U.S.). And even if the Palestinians are not planning to go to the ICC or to try to sanction Israel in various ways subsequent to a U.N. vote, that might be the future trajectory for this conflict and a U.N. vote might ultimately encourage that, which is likely to present a series of difficult decisions down the road (in this case especially for the Europeans). The main explanation for U.S. opposition to any U.N. consideration of a Palestine resolution would appear to be rooted in the domestic politics of this issue. With re-election coming up (isn't it always) the president would be unenthusiastic about having to deal with the background noise criticism that many of the so-called pro-Israel lobbying groups would undoubtedly generate in the wake of any U.N. vote. Even a U.S. veto in the Security Council or "no" vote in the General Assembly would not shield the president from being attacked. He will be blamed for encouraging the Palestinians to try this path by stating in his speech last year to the UNGA that "when we come back here next year, we can have an agreement that will lead to a new member of the United Nations -- an independent, sovereign state of Palestine." The president is also likely to be held accountable for failing to sufficiently persuade or pressure any state with whom American maintains bilateral relations and that votes with the Palestinians. Yes, it is ridiculous. Republican congressional leaders have threatened to withhold America's UN payments if such a vote goes ahead, giving the president another horse-trading headache in the already difficult act of managing congressional relations. What's more, members of Congress from both parties are threatening to de-fund all U.S. assistance to the Palestinian Authority if the Palestinians push a U.N. vote. This matters because administration officials understand that de-funding might not only encourage escalation on the ground, but it also removes an important lever of U.S. influence with the Palestinians for managing the conflict in ways that are convenient to Israel. A classically ironic own goal for the pro-Israel community, this one. There is also the small matter of America's own national interests and credibility at the U.N., in the Middle East, and in the broader global community. If there is a U.N. vote and domestic politics dictates a US "no" vote, then while no direct causal line can be drawn between that vote and increased extremist recruitment, terror, and threats against the U.S.,the relationship between those factors is nonetheless one that American leaders and especially military leaders are all too aware of. The distinctly European reasons for also preferring that a U.N. move be avoided mainly revolve around the difficulty that exists in producing a common European position and in the absence of such a position the inability to bring leverage to bear and the exposing of divisions within Europe. Given the shared point of departure on the desirability of producing an alternative to the Palestinian push at the UN it might seem somewhat surprising that the U.S., Europe, and the rest of the Quartet failed to produce a common statement at last week's high level meeting. Surprising, that is, until one considers what was on offer from the U.S. -- which is where the American sophistry comes in. The U.S. presented to its Quartet "partners" a suggested one page text that looked rather like an exercise in cherry picking Obama's recent speeches by the Israeli Prime Minister's office (given the recent traffic between Jerusalem and Washington and the end product it is reasonable to speculate that that is precisely what happened). The American pitch went something like the following: the proposed text is a reflection of the President's speech, the Quartet had encouraged the President to give such a speech, the President had taken some political heat for the speech, the Quartet had even endorsed the speech (which it did in a May 20 statement), therefore the Quartet should now stand united behind the American draft, demonstrate to the Palestinians that they have no alternative but to accept the Quartet position, resume negotiations, and drop the U.N. idea. The text was quite clearly pre-cooked with the Israeli leadership, so no problem of acceptance from Israel. Except that the U.S. text was not a faithful rendition of what the Quartet had endorsed -- namely, the May 19 State Department speech of the president -- but rather a hodgepodge of language from that speech, from the May 22 speech at the AIPAC conference, and of elements never before endorsed by the Quartet and even contradicting the existing positions of the EU and others. Hence the stalemate -- and not altogether a shock given Jerusalem's apparent co-authorship of the text. So here are the details. To recap: President Obama's May 19 speech spent 1,040 words addressing the Israeli-Palestinian conflict. Obama described the conflict, touched on Israeli and Palestinian aspirations, and made a case for a solution being more urgent than ever in the context of the Arab awakening. The President then made news when, in calling for a resumption of negotiations, he stated that "the basis of those negotiations is clear," and then spent 170 words providing the parameters of a borders and security first approach to achieving two-states (his reference of the 1967 lines in particular drew attention). He closed out this part of the speech by saying "these principles provide a foundation for negotiations." The U.S. draft proposal presented to the Quartet did include the President's language from the May 19 speech, but it also included a whole lot more, all of it skewing, extremely uni-directionally, in Israel's favor. To the simple May 19 border language of "based on the 1967 lines with mutually agreed swaps," the U.S. added the following from the May 22 speech: “The parties themselves will negotiate a border between Israel and Palestine that is different than the one that existed on June 4, 1967, to take account of changes that have taken place over the last 44 years, including the new demographic realities on the ground and the needs of both sides. This is essentially America asking the Quartet to endorse illegal Israeli settlement activity

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induced significant (p < 0.05) elevations in cardiac tissue concentrations of nitric oxide and malondialdehyde as well as serum levels of cardiac injury biomarkers (lactate dehydrogenase, creatine kinase, and creatine kinase-MB) and proinflammatory cytokines (interleukin-1β, and tumor necrosis factor-alpha). The histopathological examination showed necrotic and degenerative changes in the cardiac tissue, while immunohistochemical analysis revealed marked myocardial expression of activated caspase-3 and cyclooxygenase-2, following DOX adminstration. Allicin pretreatment significantly improved (p < 0.05) all examined parameters, and restored the cardiac architecture. The current study demonstrated that allicin effectively mitigates cardiac oxidative damage, apoptosis and inflammation, induced by acute DOX intoxication. Therefore, allicin could be a promising cytoprotective agent against DOX cardiotoxicity.Seven years after the last Harry Potter sets were released, LEGO has unveiled a number of exciting new Harry Potter and Fantastic Beasts themed builds. The centrepiece of the new products is an epic 6000+ piece (!) Hogwarts Castle and grounds. The new sets feature iconic scenes from the 8 ‘Potter’ films, as well as two Fantastic Beasts and Where to Find Them sets (including an exciting new Crimes of Grindelwald build). A number of new minifigures are also included with the new releases. The new sets include Aragog’s Lair, the Whomping Willow and castle, The Great Hall, the Hogwarts Express and a Quidditch Match. The Fantastic Beasts sets include Newt’s Case (complete with a number of magical creatures) and Grindelwald’s Escape (in what looks to be a Thestral-and-cart), a new scene we’ll learn more about in the Crimes of Grindelwald film. The epic highlight of the new sets is a 6020-piece Hogwarts Castle, LEGO’s second largest set (behind the Star Wars Millenium Falcon). The castle showcases a number of iconic scenes from the ‘Potter’ films, and includes 4 minifgures (the four Hogwarts founders) and 27 character microfigures.Don’t Worry (or Celebrate?) Rick Santorum will Not be the Next President, by Lawrence Spaulding …even if he wins the Iowa caucuses or comes in second, or third. And Ron Paul won’t be the next president if he wins either. Really. The importance of Iowa is not that it picks the winner, just ask President Pat Robertson or President Mike Huckabee, instead it helps identify the losers (or more gently it “winnows the field.”) Iowa is not about delegates, only a few are at stake, so don’t be distracted by that tally. Instead it can reveal and effect who can keep raising money and who can’t, as well as who has the capacity for campaign organization and who doesn’t. If Michele Bachmann can’t land in the top 3-4 in her neighboring state and where she has been campaigning for the greater part of a year, can she do better in Florida? In South Carolina? If a fire breathing social conservative like Rick Perry can’t end up in the upper tier in Iowa, can he perform well in New Hampshire or Florida? If Newt Gingrich floats like a stone in Iowa, where can he do better? These candidacies may limp on for a few more weeks hoping for an implosion elsewhere in the field. So, is the nomination Romney’s? If yes, it is not because he wins delegates in Iowa or comes out on top in the polls; but showing well in Iowa makes it more difficult for others to close the gap, narrow as it is. He can keep chugging along, slowly gobbling up more and more endorsements and raising more and more money even if he generates little enthusiasm. He can stub his toe here and there, and still do fine so long as doesn’t actually stumble and fall in a way he has shown no inclination to so far. The question for Republicans is what makes their eventual candidate the strongest against President Obama. A bruising nomination fight can certainly hurt and show a candidates’ vulnerability. On the other hand, a hard fought primary season can strengthen a candidate. Senator Obama may have become President Obama even without the hard fought primary battle with Senate Clinton, but it is hard to doubt that those contests made him a much stronger candidate. Mitt Romney has shown himself to be an aggressive, well-disciplined, well organized candidate, but so far the pre-primary period has not shown if he can take a punch. Iowa won’t reveal that neither will New Hampshire. And if not then, it might be fall before we find out. – Lawrence Spaulding Also: Googling ‘Santorum’ Leads to Nationwide EwwwwsSaturday, June 28, 2008 We do more than we think and Sat. Habit I think as moms that we think we dont do much if all the house isnt neat and tidy 24 -7. I have decided we all do more than we think !!!!Yesterday when Angel wanted to go swimming I had to vaccum the pool which wasnt on the list but what about the other things. I mean we make meals and then pick up without realizing it and finally we are responsible for waking the children, tending to their needs or wants all day , driving them places , making snacks, getting them ready for bed , finally tucking them in. I think with all these responsibilities we need to be easier on ourselves. It made me wake up and realize this especially because now I am also activity organizer for the summer and chauffeur too. All the hats we wear doctor, nurse, cook, housecleaner, activity director, chauffeur, hairdresser, personal dresser and finally mommy which encompasses it all.( I am sure I missed a few) Today I started on my backyard by scrubbing down the plastic chairs with the wonderful Mr.Clean sponge and wiping down the table too . I will need to go out and buy some plastic tablecloths for my two tables sometime this week. So for my Sat. habits I was looking around today and noticed there were many spots that dont get cleaned on a regular basis and I want to change that. The spots I was looking at were window sills, doors, windows, baseboards, and door frames. My habit is going to make sure I do at least one of these in a room each day so by the end of the summer it will be all done.Today I wiped down the front door, the framing around our mirror closet door, windexed the front door too. It looks so much better and makes me feel good too to get rid of a lot of dirt.I am going to start working on Anthea Turners book " The Perfect Housewife" so I dont miss anything in each room. I will add to her lists in each room if I have anything to add.I also am going to try three new recipes this week. Maybe by the end of summer I will be doing the menu planning for the week. I want to try and have some homemade baking done every week too.So this weeks will be banana bread.Well off to spend some time with my family.Have a great weekend. 1 comment: Diane - I love this post...especially the part about mom jobs. I totally agree with you. Sometimes I feel like I haven't gotten anything done, when I look around and see a mess everywhere. But in reality, a lot has gotten done, you just can't see it sometimes! Once you get your fridge and freezer done, post a pic! I'll share another simple idea for fridges tomorrow! :) About Me I am a mother to an awesome thirteen year old girl and married to a wonderful husband. I decided to blog to help me get organized and share my life experiences too as we go along so we can motivate and support one another !! Slow and steady wins the race they say. Join me on my journey !!!!!!!!!Mac & Shews Serves 8 Time: 1 hour || Active time: 30 minutes I don’t think vegans ever get sick of Mac & Cheese, or, “Cheeze” or whatever. One of the first recipes I ever tried was from one of my all time favorites, the New Farm Cookbook. It was great for me back then because I always had a ton of people over, and you could make it for a crowd at the drop of a hat. So if you were all sitting around watching Evil Dead 2 on repeat, it was only a matter of time before a magical pot of Mac & Cheese would appear and swallow your soul. That recipe is still the prototype for many a vegan Mac & Cheese recipe: lots of nooch, garlic, onions and, wait, what’s that? Half a cup of margarine?! This was the 80s and so it wasn’t even non-hydrogenated margarine. It was the real deal – a bright yellow log of pure processed fat. Today we have less ungodly ingredients to work with, but still, I can’t shake the feeling that when I eat those types of Mac & Cheese, I’m eating melted margarine. So I’ve been toying with different ingredients for the past few years and I’ll probably continue to mess around with it. It’s all about developing flavor and creaminess with ingredients that are still really accessible and really delicious, but also way less processed, and, well really real. To keep things from being one note, I wanted to build flavor with a few simple